WEBVTT

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[MUSIC PLAYING]

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SPEAKER 1: The microtome
can section tissue

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to thicknesses of about
20 to 50 million microns.

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The electron microscope can
then make magnifications

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of 100,000 times or more.

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Such detailed views of
mammalian ovum and sperm

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are a very recent possibility.

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But there was serious
interest in the processes

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of reproduction long ago.

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People have always wanted to
influence their own fertility.

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Earlier methods
were often magical,

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but there is an ancient history
to abortion and infanticide.

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Greek and Roman physicians knew
a great deal about gynecology.

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Delivery itself
continued for centuries

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to be largely the
responsibility of midwives.

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High birth rates were
balanced by fetal wastage,

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infant mortality, and
generally high death rates.

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Population remained
about stable.

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The great change had its
source in the Renaissance

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in the beginnings
of modern science

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and the agricultural and
industrial techniques,

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which it fostered in the
beginnings of modern medicine.

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[MUSIC PLAYING]

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The great change was that the
death rate in Europe, which

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had remained relatively
stable for thousands of years

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began to go down.

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This decline at first gradual
accelerated more and more

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in the ensuing centuries.

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But the birth rate,
which up to this point

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had been in a state of
more or less equilibrium

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with the death rate, did not
decrease at the same pace.

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The disparity between
these two lines,

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the so-called
demographic gap accounts

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for the rapid increase
in population, which has

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characterized the modern world.

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In the older
countries of Europe,

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the birth rate was gradually
brought down close to the death

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rate by coitus interruptus
illegal abortion and foundling

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homes, which were a thinly
disguised form of infanticide.

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In the 20th century, a
more rational approach

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to fertility control
won strong support,

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not only from crusaders
like Margaret Sanger

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but also from physicians like
Abraham Jacoby and Robert Latou

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Dickinson.

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Technical innovations, such
as the vocalization of rubber

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began to make contraception
more practical.

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But meanwhile, the problem
had been posed on a new scale.

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Consider the world of
the mid-20th century.

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Consider, for
example, childbirth.

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In a modern hospital,
it is managed

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by a highly trained team.

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Medical science and
technology have drastically

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reduced the danger
to mother and child.

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[NON-ENGLISH SPEECH]

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Personnel and equipment are
prepared for the contingencies,

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which used to mean death.

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[NON-ENGLISH SPEECH]

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This baby will almost certainly
survive his first year.

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He will in all probability
live to be more than 70.

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In much of the world, births
occur in circumstances

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more like this.

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But even fragmentary
influences of modern science

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cause radical alterations in the
balance between life and death.

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This maybe too has
a chance of living,

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of surviving to
maturity and to old age

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far beyond what he would
have had 50 years ago.

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[CRIES]

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In other words, there has been
a sharp drop in the death rate.

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But birth rates
have remained high,

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especially in the less
developed areas of the world,

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where the impact of technology
has been sudden and uneven.

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There is an enormous demographic
gap, a runaway growth.

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[CAR ENGINE]

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This growth has begun to
have appalling consequences.

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[CAR ENGINE]

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[CHATTER]

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Harrison Brown expert on
World Resources says--

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HARRISON BROWN: It is beginning
to look as though the struggle

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to increase the well-being
of the people of the world

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is being defeated by the
sheer increase in numbers.

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There are large portions of the
Earth in which, for example,

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recent increases
in food production

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have not kept up with the
increases in population,

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and there is less food to
eat per person each year.

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It is quite likely that if
birth rates do not come down,

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death rates will
start back up again.

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SPEAKER 1: For many of
those who do survive,

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the outlook is somber.

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SALLY SWING SHELLEY: There
are about 20 to 25 million

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more illiterates every year.

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SPEAKER 1: Sally
Swing Shelley, UNESCO.

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SALLY SWING SHELLEY: A quarter
of a billion school age

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children in the world
do not attend school.

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PHILIP M. HAUSER: What makes
this growth so alarming

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is that the rate of increase is
not arithmetic but geometric.

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SPEAKER 1: Philip M.
Hauser, demographer.

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PHILIP M. HAUSER: The number
of people in the world

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has increased as much
in the past 50 years

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as it increased in
1,000 years before.

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The present world population
of slightly over 3 billion

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will at the current rate of
increase be more than 6 billion

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by the year 2000, 12 billion
by the year 2040, 24 billion

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by 2080 and so on.

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[CHATTER]

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SPEAKER 1: It is tempting to
think of this only as a problem

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for distant peoples
in faraway lands,

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but it is a worldwide problem.

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In the United States
alone if it continues

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to grow at its present
rate will in 100 years

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reach a population of
1 billion seriously

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threatening the quality of
life for all levels of society.

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Dr. John Rock says--

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JOHN ROCK: A society
which practices

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death control must at the same
time practice birth control.

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SPEAKER 1: In fact, governments
and private organizations

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all over the world
have begun to work

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with the medical profession
toward effective and acceptable

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family planning.

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Dr. Alan F. Guttmacher,
president of Planned Parenthood

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World Population says--

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ALAN F. GUTTMACHER:
Today there's

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a highly developed technology
of contraception resulting

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in increasingly wide range of
effective and tested methods

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of fertility control.

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[MACHINE]

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SPEAKER 1: The more
traditional of these methods

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used not only mechanical
barriers but also a variety

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of spermicide preparations.

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The orals interfere with
the reproductive process

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at an earlier stage.

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In the human ovulatory
cycle, the hypothalamus

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produces a
neurohumoral substance

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which stimulates the pituitary
to secrete FSH, the Follicle

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Stimulating Hormone,
and LH, which

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is responsible for the rupturing
of the Graafian follicle

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and the release of the ovum.

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The ruptured follicle
becomes the corpus luteum,

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which releases
progesterone and estrogen.

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They inhibit the release of
the neurohumoral substance

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and consequently of FSH
and LH, thus preventing

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further ovulation
during the cycle.

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When the corpus
luteum atrophies,

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its inhibitory influence on
the hypothalamus is removed,

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and the entire
process is repeated.

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During pregnancy, the
placenta continues the supply

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of progesterone and
estrogen maintaining

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the inhibition of ovulation.

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The oral contraceptive supply
progesterone and estrogen

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like substances, thus preventing
ovulation in much the same way.

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The use of a basal
temperature record

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to record the
occurrence of ovulation

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may be helpful for the
people who choose the rhythm

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or safe period technique.

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The IUD or
Intrauterine Device has

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been found to provide extremely
effective contraception.

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Made of a chemically
inert substance,

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it is inserted
through the cervix.

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Inside the uterus, it
resumes its original shape.

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Vasectomy is gaining increasing
acceptance in countries

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as far apart as India
and the United States

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where 40 to 50,000 are
performed each year.

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There's a relatively
simple operation

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and does not diminish
either libido or potency.

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Tubal ligation can
be accomplished

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either vaginally or abdominal.

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It has no effect on
menstruation or ovulation.

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One of the most common
means of limiting the number

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of offspring and in a way that
is very old is still abortion.

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In countries in which
abortion is illegal,

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it is often induced by people
outside the medical profession

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or self-induced.

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Many of these women arrive
at the emergency wards

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of hospitals claiming
that they have

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begun to abort spontaneously.

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All too often, they
are actually suffering

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from illegal and
inept abortions.

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This is one of the reasons
that the governments

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of some countries have legalized
abortion, for example, Hungary.

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Any woman may apply
for an abortion

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and be almost certain that
her request will be granted.

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The operation is performed
on a regular medical basis.

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Mortality and morbidity
rates are extremely low.

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[NON-ENGLISH SPEECH]

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Current research is
suggesting other approaches

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to fertility
control, but whatever

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methods are used now
and in the future,

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the overall point seems clear.

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A.S. PARKS: Progressive increase
in maternal care associated

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with various degrees
of paternal care

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is a notable feature in
the evolution of the higher

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animals.

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SPEAKER 1: A.S. Parks,
British physiologist.

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A.S. PARKS: And
the process may be

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said to have reached a
peak with the appearance

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of the human family in which
parental care continues

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long after the biological
need for it has ended.

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The greater the care
taken of each offspring,

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the fewer the offspring
that can be dealt with.

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SPEAKER 2: Thank you.

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SPEAKER 1: The resolution of
the American Medical Association

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states that an
intelligent recognition

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of the problems that relate
to human reproduction,

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including the need
for population control

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is more than a matter of
responsible parenthood.

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It is a matter of
responsible medical practice.

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SPEAKER 3: Well.

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SPEAKER 4: Easter was here.

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SPEAKER 1: Yeah,
that's a hard day.

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The physician who supervises
pregnancy and childbirth

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has many opportunities to broach
the subject of contraception.

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SPEAKER 3: This is
your second pregnancy,

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and you will notice
that this is true--

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SPEAKER 1: Often he may have
to bring it up quite directly.

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SPEAKER 3: Let's see.

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How many have you had, ma'am.

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SPEAKER 5: Three.

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SPEAKER 3: Three,
and you're about

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ready to have your
fourth one, are you?

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SPEAKER 5: That wasn't
what I planned, but then I

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hadn't planned on three either.

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SPEAKER 3: I see.

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Are you planning to control your
additional family in some way?

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SPEAKER 5: Oh, we
thought we were.

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SPEAKER 3: How are you
going to go about that?

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SPEAKER 5: Well, I wanted
to ask you about the--

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SPEAKER 3: How man are you
going to have, about six?

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SPEAKER 6: Oh, no.

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SPEAKER 3: No.

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SPEAKER 6: This is it.

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SPEAKER 1: Even though
she has not said so,

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the patient may be hoping for
guidance from her physician.

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SPEAKER 6: Well.

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SPEAKER 3: You have plans
for future contraception,

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or how are you
going to continue?

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SPEAKER 6: I don't know.

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That's what I want
to talk to you about.

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SPEAKER 3: I see.

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It's a little bit early to
discuss it at this point,

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but since you mentioned
that you're not

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going to have any more
way, what type were you

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contraception were you
thinking that you--

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SPEAKER 6: I have no idea.

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I thought I talked to you and
find out what you'd suggest.

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SPEAKER 3: Well, now as
far as their percentage

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of prevention of pregnancy.

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SPEAKER 7: I don't
know enough about--

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SPEAKER 1: Previous success
with a particular method

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is important.

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SPEAKER 7: Sure.

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I've always used it
in diaphragm before.

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SPEAKER 3: You've always used it
successfully then, haven't you?

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SPEAKER 7: Yes.

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Yes.

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SPEAKER 3: Well, I would suggest
that then as I do to other

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patients that if you are
using a successful method

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of contraception and you're
happy with it and your husband

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is, then you shouldn't--

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SPEAKER 1: It has been said
that the most effective

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contraceptive is the one
that the patient will use.

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SPEAKER 8: Oh, I
wanted the pills.

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SPEAKER 3: I see.

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Now do you have any
knowledge of pills?

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Have you used them before?

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SPEAKER 8: No.

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No.

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SPEAKER 3: I see.

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Well, I'll explain it to
you a bit and how it works

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and also how you use it.

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Now the pill, as you may
know, is a hormone pill,

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and it works by preventing
ovulation or preventing

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your ovaries from
producing eggs.

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That's the way that
they accomplished this.

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And now you will
have to wait until

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your next menstrual period
before you can start them.

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SPEAKER 1: Careful
explanation is

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particularly
important for patients

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who choose the rhythm method.

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SPEAKER 3: Now there's a much
more constant relationship

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we feel between ovulation
and the next menstrual period

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than ovulation in the
preceding menstrual period.

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Now for instance, if your cycle
would be regularly 28 days,

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that would mean that the 14th
day is right in the middle.

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And so that means that 14
days after a menstrual period

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and 14 days before a
menstrual period, you ovulate.

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SPEAKER 1: In
addition to the office

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of the private physician,
this kind of guidance

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is offered in Planned Parenthood
clinics and more and more

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in the clinics of
public hospitals.

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SPEAKER 9: Literature here.

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You can take it home,
discuss it with your husband.

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If you've made up your
mind when you are at home,

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please call the clinic back
and change your postpartum

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appointment.

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SPEAKER 1: Lack of birth
control information

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has been a primary cause
of excessive multipolarity,

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especially among the poor.

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SPEAKER 9: This is the
female reproductive organ.

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This is the womb or the uterus,
where the baby normally grows.

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SPEAKER 1: Every
serious study undertaken

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indicates that members of
all socioeconomic groups

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in the United States, regardless
of race or national background,

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would prefer to have
families of limited size

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and do make use of
family planning services

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when they are available.

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SPEAKER 10: Well, I
don't want more children.

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I think that's more than enough.

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SPEAKER 11: Your husband agrees.

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SPEAKER 10: Yes, uh-huh.

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SPEAKER 11: Well, I
think you have plenty.

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SPEAKER 10: We did
one little girl

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being that we have all six boys.

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SPEAKER 11: Oh my gosh.

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SPEAKER 10: But, well, that's--

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it's too much anyway.

24:40.430 --> 24:43.768
We'll just have to
do without that girl.

24:43.768 --> 24:45.310
SPEAKER 11: How have
you been feeling

24:45.310 --> 24:46.420
since the baby was born?

24:46.420 --> 24:47.470
SPEAKER 10: Real good.

24:47.470 --> 24:48.070
SPEAKER 11: No problems?

24:48.070 --> 24:49.210
SPEAKER 10: No, no problems.

24:49.210 --> 24:50.530
SPEAKER 11: When you
were upstairs, did

24:50.530 --> 24:51.940
you go to the lectures about--

24:51.940 --> 24:53.320
SPEAKER 10: Yes, I did, uh-huh.

24:53.320 --> 24:55.660
SPEAKER 11: And Mrs.
Fredericks talked to you

24:55.660 --> 24:57.948
about the various methods
that we have available.

24:57.948 --> 24:58.990
SPEAKER 10: Yes, she did.

24:58.990 --> 25:02.110
She talked to us about
the different ways

25:02.110 --> 25:04.475
that they could help
us in this program.

25:04.475 --> 25:06.850
SPEAKER 11: Did you find one
that seemed to interest you?

25:06.850 --> 25:11.020
SPEAKER 10: Yes, I found
that the hoop or loop I think

25:11.020 --> 25:13.950
is what they call it
is the one I'd like to.

25:13.950 --> 25:15.325
SPEAKER 1: In the
clinics just as

25:15.325 --> 25:17.200
in the office of the
private physician,

25:17.200 --> 25:19.458
patient choice is crucial.

25:19.458 --> 25:21.250
SPEAKER 11: Have you
seen one of the loops.

25:21.250 --> 25:22.417
SPEAKER 10: Yes, we've seen.

25:22.417 --> 25:24.445
I seen one when I
was in the hospital.

25:24.445 --> 25:26.320
SPEAKER 11: They're just
made out of plastic.

25:26.320 --> 25:28.487
We straighten them out in
this fashion to put it in,

25:28.487 --> 25:30.250
and then it just
automatically snaps back

25:30.250 --> 25:32.440
in its little loop shape.

25:32.440 --> 25:34.930
And the white part of the
loop stays inside the uterus

25:34.930 --> 25:37.180
or the womb like this.

25:37.180 --> 25:40.210
With the threads coming out
through the mouth to the uterus

25:40.210 --> 25:42.108
into the top of the vagina.

25:42.108 --> 25:44.650
And then I just, sort of, like
to have you feel these threads

25:44.650 --> 25:45.733
so that what they're like.

25:49.670 --> 25:54.340
And the loop here too
just to feel this.

25:54.340 --> 25:55.870
When you examine
yourself as long

25:55.870 --> 25:58.397
as you can feel just the
threds, everything's all right.

25:58.397 --> 25:59.980
There are some
problems with the loop,

25:59.980 --> 26:02.980
and you have to understand
about this before we get started

26:02.980 --> 26:04.370
or you might get discouraged.

26:04.370 --> 26:08.530
But, for instance,
there's liable to be

26:08.530 --> 26:10.780
some cramping like a--

26:10.780 --> 26:12.850
do you have cramps with
your menstrual period?

26:12.850 --> 26:15.550
SPEAKER 10: Not usually,
not unless I've been

26:15.550 --> 26:17.290
working a little hard before.

26:17.290 --> 26:19.990
But otherwise, I have pretty
good menstrual periods.

26:19.990 --> 26:23.140
SPEAKER 11: There's liable to
be some cramping for some women

26:23.140 --> 26:26.540
tell us two or three hours,
some say two or three days.

26:26.540 --> 26:28.450
Some say they have
no problems at all.

26:28.450 --> 26:31.000
For a while after the
loops been put in,

26:31.000 --> 26:33.430
just a little vague,
sort of, cramping

26:33.430 --> 26:37.890
feeling low in your abdomen.

26:37.890 --> 26:40.580
Your first few
periods that you have,

26:40.580 --> 26:46.430
your menstruation is
likely to be quite heavy,

26:46.430 --> 26:49.600
heavy enough to worry a little
bit, but this is expected.

26:49.600 --> 26:51.350
And that's why I want
to tell you about it

26:51.350 --> 26:53.413
so it doesn't scare you.

26:53.413 --> 26:54.830
SPEAKER 1: Success
depends largely

26:54.830 --> 26:57.530
upon the care with which the
physician explains the chosen

26:57.530 --> 27:00.470
method and the
degree to which he

27:00.470 --> 27:02.390
responds to the
needs and concerns

27:02.390 --> 27:05.653
of each particular patient.

27:05.653 --> 27:07.070
SPEAKER 11: This
is a safe method.

27:07.070 --> 27:09.380
You're not worried
about that, are you?

27:09.380 --> 27:10.970
SPEAKER 12: No, I
have a girlfriend

27:10.970 --> 27:12.163
say you could get cancer.

27:12.163 --> 27:13.580
SPEAKER 11: Well,
that's not true.

27:13.580 --> 27:13.970
SPEAKER 12: I know.

27:13.970 --> 27:15.550
The nurse explained
it to us when she--

27:15.550 --> 27:17.180
SPEAKER 11: You can get
cancer, but this doesn't

27:17.180 --> 27:18.710
make the chances any greater.

27:18.710 --> 27:22.130
You still have the same chances
that any other woman has.

27:22.130 --> 27:23.896
SPEAKER 12: Well, I
didn't believe that.

27:23.896 --> 27:25.520
And plus I read a little
little bit about it in--

27:25.520 --> 27:26.480
SPEAKER 11: One
of the advantages

27:26.480 --> 27:28.272
of coming to see us
every year is we always

27:28.272 --> 27:30.950
do the cancer test, of course,
and we find it at the earliest

27:30.950 --> 27:31.760
possible moment.

27:34.440 --> 27:36.480
SPEAKER 13: And if I want
to have a baby later,

27:36.480 --> 27:37.610
can it be taken out?

27:37.610 --> 27:39.277
SPEAKER 11: Yes, you
just take this out,

27:39.277 --> 27:43.910
and then you perfectly easy
to become pregnant again.

27:43.910 --> 27:47.030
That's true, of course,
with the pills too.

27:47.030 --> 27:49.640
Now no matter
whether your period

27:49.640 --> 27:55.100
lasts two days or seven
days or four days,

27:55.100 --> 27:59.240
you always start taking
your pills on day five, OK.

28:02.033 --> 28:03.700
The day that you start
taking your pills

28:03.700 --> 28:06.850
is not determined by
when your period stops.

28:06.850 --> 28:09.265
It's determined by when
your period starts,

28:09.265 --> 28:14.140
and it's always five days after
the first day of bleeding, OK.

28:14.140 --> 28:16.810
So your period could
stop here or here or here

28:16.810 --> 28:19.480
or here or maybe even
here, but you still

28:19.480 --> 28:20.965
start the pills on day five.

28:23.500 --> 28:28.060
Now the pills are taken
one pill a day every night.

28:28.060 --> 28:30.460
The nighttime is the
best time to take them

28:30.460 --> 28:33.370
for 20 days in a row, OK.

28:36.750 --> 28:39.360
EDRIS RICE-WRAY: After working
in public health for 11 years

28:39.360 --> 28:43.410
I suddenly realized that it's
useless to go on saving lives

28:43.410 --> 28:46.502
if we aren't willing to do
anything about the birth rate.

28:46.502 --> 28:48.210
SPEAKER 1: Edris
Rice-Wray is a physician

28:48.210 --> 28:50.850
working in public health.

28:50.850 --> 28:52.500
The Mexican village
she is entering

28:52.500 --> 28:54.600
is typical of the
rural areas in which

28:54.600 --> 28:58.025
much of the world's population
growth is taking place.

28:58.025 --> 29:04.517
[CAR]

29:04.517 --> 29:06.350
EDRIS RICE-WRAY: We
have found that in order

29:06.350 --> 29:08.930
to start a program, it's
very worthwhile to have

29:08.930 --> 29:12.140
a meeting with the mothers.

29:12.140 --> 29:13.760
Talk to them and
find out how they

29:13.760 --> 29:16.160
feel about their large
families, and then you

29:16.160 --> 29:18.965
learn IF they want advice as
to how to space their children.

29:21.797 --> 29:23.630
SPEAKER 1: In addition
to being a physician,

29:23.630 --> 29:27.170
the public health doctor must
be something of a sociologist

29:27.170 --> 29:29.760
as well as an educator.

29:29.760 --> 29:31.850
EDRIS RICE-WRAY: In
order to start a program,

29:31.850 --> 29:34.670
it's necessary to begin
teaching them the basic facts

29:34.670 --> 29:35.510
of reproduction.

29:35.510 --> 29:38.570
[NON-ENGLISH SPEECH]

29:54.560 --> 29:57.050
After we talk to the
mothers, then the next step

29:57.050 --> 30:02.720
is to orient the nurse who will
be carrying out the program.

30:02.720 --> 30:11.180
[NON-ENGLISH SPEECH]

30:11.180 --> 30:13.670
SPEAKER 1: George Brown is
also a physician specializing

30:13.670 --> 30:15.830
in population problems.

30:15.830 --> 30:18.890
He works closely with
Tunisian officials,

30:18.890 --> 30:21.680
who have initiated an active
birth control program.

30:21.680 --> 30:25.173
[MUSIC PLAYING]

30:45.650 --> 30:48.860
The Tunisian maternal and
child care centers offer

30:48.860 --> 30:53.960
along with their other services
help in family planning.

30:53.960 --> 30:55.970
Medical indications
for contraception

30:55.970 --> 30:58.130
are particularly
frequent among the poor.

30:58.130 --> 31:01.609
[MUSIC PLAYING]

31:54.300 --> 31:57.270
George Brown's role is not
that of the typical practicing

31:57.270 --> 32:00.120
doctor private or public.

32:00.120 --> 32:03.450
He is a consultant
and an advisor.

32:03.450 --> 32:05.250
The government of
Tunisia has decided

32:05.250 --> 32:08.130
that no program of social
and economic improvement

32:08.130 --> 32:10.200
can succeed unless
it is accompanied

32:10.200 --> 32:14.370
by an effective birth
control program.

32:14.370 --> 32:17.160
Many physicians contribute to
the field of fertility control

32:17.160 --> 32:18.610
by doing research.

32:18.610 --> 32:20.490
One example is
Luigi Mastroianni,

32:20.490 --> 32:22.980
professor at the
University of Pennsylvania.

32:22.980 --> 32:25.230
LUIGI MASTROIANNI: Well,
it's been known for some time

32:25.230 --> 32:29.130
that the presence of a foreign
body in the uterine cavity

32:29.130 --> 32:32.520
materially affects
reproductive processes.

32:32.520 --> 32:35.760
As a matter of fact,
recently several devices

32:35.760 --> 32:39.420
have been developed which have
been proved safe and effective,

32:39.420 --> 32:45.000
and they are very useful as
a method of family planning.

32:45.000 --> 32:49.080
The mechanism of action
behind the presence

32:49.080 --> 32:51.510
of an intrauterine
device is one which

32:51.510 --> 32:54.390
is a matter of
continuing speculation.

32:54.390 --> 32:56.580
Many people have
felt for some time

32:56.580 --> 32:58.680
that they act at
the uterine level

32:58.680 --> 33:02.910
by some interference with
myometrial or endometrial

33:02.910 --> 33:06.660
behavior, but a
few investigators

33:06.660 --> 33:09.360
have suggested that they
act at the tubal level

33:09.360 --> 33:12.600
by causing a rapid transport
of ova from the fallopian tube

33:12.600 --> 33:14.920
into the uterus.

33:14.920 --> 33:17.130
Well, in order to
get at the problem,

33:17.130 --> 33:22.260
we decided to study the effect
of the intrauterine device

33:22.260 --> 33:26.640
on reproductive
processes in the monkey.

33:26.640 --> 33:30.330
For our experiments, we chose
the macaque [INAUDIBLE] monkey

33:30.330 --> 33:32.850
largely because the
reproductive processes

33:32.850 --> 33:36.420
in that species of monkeys
have resembled that of people.

33:38.970 --> 33:43.170
The intrauterine
device was introduced

33:43.170 --> 33:48.060
from below without
much difficulty.

33:48.060 --> 33:53.460
Now we used a Margulies
spiral, which was cut to size,

33:53.460 --> 33:57.900
and I think one of the reasons
we were able to introduce this

33:57.900 --> 34:00.930
into the group of monkeys
we were working with

34:00.930 --> 34:03.992
was that these monkeys all
had recently born young.

34:03.992 --> 34:05.325
That is they were Paris monkeys.

34:12.040 --> 34:15.040
The monkeys incidentally were
obtained directly from India.

34:15.040 --> 34:16.870
They were introduced
into the laboratory.

34:16.870 --> 34:19.719
And after the device
was introduced

34:19.719 --> 34:22.000
into a group of these
monkeys, their cycles

34:22.000 --> 34:24.654
were carefully followed
by daily vaginal smears.

34:33.310 --> 34:36.400
The animals were observed
in captivity for a month

34:36.400 --> 34:40.840
or two over one or two
cycles, and subsequently they

34:40.840 --> 34:46.000
were treated with human urinary
pituitary gonadotropin in order

34:46.000 --> 34:48.489
to induce super ovulation.

34:48.489 --> 34:51.340
It was reasoned that
within a matter of hours

34:51.340 --> 34:53.409
after the last
ovulating injection,

34:53.409 --> 34:55.075
super ovulation
would have occurred.

34:58.460 --> 35:02.590
Now on the last three days
of gonadotropin treatment,

35:02.590 --> 35:06.100
we did artificial
insemination on our monkeys.

35:06.100 --> 35:09.205
And for this, we used
electro ejaculated semen.

35:20.550 --> 35:23.070
Semen was taken
in the fresh state

35:23.070 --> 35:25.650
and immediately
after liquefaction,

35:25.650 --> 35:27.450
the liquefied portion
of the specimen

35:27.450 --> 35:29.033
was introduced into the vagina.

35:29.033 --> 35:31.200
And this was followed by
the coagulant, which should

35:31.200 --> 35:32.595
have acted as a vaginal plug.

35:39.670 --> 35:42.880
Within a few hours of the
expected time of ovulation,

35:42.880 --> 35:47.110
the laparotomy was carried
out, and the fallopian tubes

35:47.110 --> 35:47.725
were flushed.

35:54.150 --> 35:56.550
Using Krebs-Ringer
phosphate solution,

35:56.550 --> 35:59.340
the effluent was collected
in a plastic receptacle

35:59.340 --> 36:02.295
placed at the fimbrated at
the end of the fallopian tube.

36:24.950 --> 36:28.265
This material was then inspected
for the presence of ova.

36:33.330 --> 36:37.620
Actually, approximately
50% of the ova,

36:37.620 --> 36:39.450
which were expected
to be present,

36:39.450 --> 36:41.820
were found in the flushing.

36:41.820 --> 36:44.670
Now these ova, which were
obtained from animals,

36:44.670 --> 36:46.560
which did not wear the coil--

36:46.560 --> 36:50.940
that is in the non-coil
control group were prepared

36:50.940 --> 36:54.300
for electron microscopy,
and several of the ova

36:54.300 --> 36:57.270
were, in fact, actually
fertilized providing us

36:57.270 --> 36:59.250
with some very
interesting specimens

36:59.250 --> 37:01.680
for electron microscopic study.

37:01.680 --> 37:04.890
Now in the group of animals in
which the coil had previously

37:04.890 --> 37:07.950
been placed, a similar
procedure was carried out.

37:07.950 --> 37:11.730
And interestingly
enough, we were not

37:11.730 --> 37:15.360
able to recover a single egg
from these animals, which

37:15.360 --> 37:17.950
were treated in
exactly the same way.

37:17.950 --> 37:19.860
There is one exception
in this series,

37:19.860 --> 37:22.320
and that was an animal in
which there were four ovulation

37:22.320 --> 37:22.980
points.

37:22.980 --> 37:25.740
And we recovered three ova.

37:25.740 --> 37:29.850
But afterwards on careful
inspection of the vagina,

37:29.850 --> 37:33.150
it was found that the coil
had been extruded probably

37:33.150 --> 37:36.090
some time previously
into the vaginal canal

37:36.090 --> 37:39.220
and was entirely
out of the uterus.

37:39.220 --> 37:41.820
So that this animal
then was reasonably

37:41.820 --> 37:43.980
excluded from the series.

37:43.980 --> 37:48.810
But our failure to recover
eggs from the animals

37:48.810 --> 37:51.120
in which the coil
have been placed

37:51.120 --> 37:54.340
suggested one of
two possibilities.

37:54.340 --> 37:55.920
Either the eggs
were not picked up

37:55.920 --> 37:58.530
by the fembrated extremity
of the fallopian tube,

37:58.530 --> 38:03.060
or if they were picked
up, they might possibly

38:03.060 --> 38:06.120
have been rapidly transported
down the fallopian tube

38:06.120 --> 38:08.980
and into the uterus prematurely.

38:08.980 --> 38:12.990
Now in order to decide which
of these two possibilities

38:12.990 --> 38:15.420
was, in fact,
operating, we carried

38:15.420 --> 38:17.460
on another set of experiments.

38:17.460 --> 38:20.460
This time we placed
a ligature right here

38:20.460 --> 38:22.800
at the uterotubal junction.

38:22.800 --> 38:25.950
The animals were then treated
in exactly the same way.

38:25.950 --> 38:29.430
The other side of
course was unlike it.

38:29.430 --> 38:34.050
When we flushed for ova, we
found that over were indeed

38:34.050 --> 38:36.060
present in the ligated
side, because they

38:36.060 --> 38:37.620
were contained by the ligature.

38:37.620 --> 38:41.130
And in fact, we had a 50%
recovery rate on this side.

38:41.130 --> 38:45.870
On the unligated side, again,
no over were recovered.

38:45.870 --> 38:48.960
So this suggested that
the eggs were picked up

38:48.960 --> 38:52.380
by the animal in which
the coil had been placed,

38:52.380 --> 38:55.560
and they were rapidly
transported down the fallopian

38:55.560 --> 38:57.510
tube and out into the uterus.

38:57.510 --> 38:59.160
But of course, on
the ligated side,

38:59.160 --> 39:04.020
they were contained in the
fallopian tube by the ligature.

39:04.020 --> 39:06.600
This was all very
nice, but where

39:06.600 --> 39:10.320
were the eggs among the
animals in which the coil had

39:10.320 --> 39:13.200
been placed, animals which
did not have the ligature

39:13.200 --> 39:14.430
placed here.

39:14.430 --> 39:16.180
Did they really get
into the uterus.

39:16.180 --> 39:18.300
And if so, how long
did they stay here?

39:18.300 --> 39:21.060
Well, in order to
explore that possibility,

39:21.060 --> 39:23.850
we made some attempts to
recover the eggs actually

39:23.850 --> 39:24.870
from the uterus.

39:24.870 --> 39:27.390
The animals were treated
in exactly the same way.

39:27.390 --> 39:31.890
They did wear coils,
and an attempt

39:31.890 --> 39:34.830
was made to recover ova
from the uterine cavity

39:34.830 --> 39:35.865
by retrograde flushing.

40:15.880 --> 40:18.670
Now in the group of
animals studied thus far,

40:18.670 --> 40:21.670
there were eight
ovulation points,

40:21.670 --> 40:26.200
and we were able to recover four
ova, four ova from the uterus

40:26.200 --> 40:28.210
at a time when they
would be expected to be

40:28.210 --> 40:30.490
present in the Fallopian tube.

40:30.490 --> 40:33.430
This suggested then that
our theory was correct

40:33.430 --> 40:36.370
and that the eggs were
indeed rapidly transported

40:36.370 --> 40:39.710
from the Fallopian
tube into the uterus.

40:39.710 --> 40:42.610
Now the matter of whether or
not these eggs are fertilized

40:42.610 --> 40:46.150
is an interesting matter indeed.

40:46.150 --> 40:49.900
Three of the four ova were
prepared for microscopic study.

40:49.900 --> 40:52.750
Unfortunately, the fourth
was lost in transit,

40:52.750 --> 40:56.560
and here we see an unfertilized
monkey egg recovered

40:56.560 --> 41:00.520
with the cumulus cells, the
corona radiata still around it,

41:00.520 --> 41:04.840
and this egg is unfertilized
as were the other two.

41:04.840 --> 41:08.710
So that we can say
that in the monkey

41:08.710 --> 41:11.200
and the super ovulated
artificially inseminated

41:11.200 --> 41:14.320
monkey, the presence of
an intrauterine device

41:14.320 --> 41:18.460
results in rapid transport of
ova from the Fallopian tube

41:18.460 --> 41:19.750
and into the uterus.

41:19.750 --> 41:22.480
And in the limited
number of eggs studied,

41:22.480 --> 41:26.860
we can say that the
ova are unfertilized.

41:26.860 --> 41:29.350
SPEAKER 1: Current research
also leads towards new methods

41:29.350 --> 41:32.200
of contraception.

41:32.200 --> 41:35.110
Suppression of
spermatogenesis, creation

41:35.110 --> 41:37.720
of immune responses
in male or female

41:37.720 --> 41:41.850
are just two promising
areas of investigation.

41:41.850 --> 41:43.890
The biology of
mammalian reproduction

41:43.890 --> 41:46.530
is extremely complex.

41:46.530 --> 41:48.960
The more we learn about
it, the more points

41:48.960 --> 41:51.432
there are at which
we can influence it.

41:51.432 --> 41:54.876
[MUSIC PLAYING]

42:10.160 --> 42:13.670
People have always wanted to
influence their own fertility

42:13.670 --> 42:16.310
essentially to have
the baby who was wanted

42:16.310 --> 42:19.670
and for whom there was an
adequate place in the world.

42:19.670 --> 42:21.860
The realization of this
hope depends heavily

42:21.860 --> 42:23.330
upon the physician.

42:23.330 --> 42:26.380
[MUSIC PLAYING]
