WEBVTT

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*This machine-generated transcript may have errors. If remediation or a manually-generated transcript is needed, please contact NLM Support at https://support.nlm.nih.gov.*

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Yeah.

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Mm.

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A.

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United States Army Medical Department Continuing

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education program,

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psychosocial aspects of hemodialysis

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and kidney transplantation with Peter

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Bridge,

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Captain,

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United States Army Medical Corps Department of

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psychiatry,

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NP Division walter reed,

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Army Institute of Research walter reed Army Medical center

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Washington,

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D.

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C.

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What I want to speak about this morning

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is to give you an overview of a

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psychosocial model of the functioning of people under

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stress,

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which I think has direct applicability

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to patients and the patients

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families who undergo transplant experience.

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Psychiatry's early involvement in the

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clinical field of transplantation

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was as a consultant who offered his

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or her services and evaluating the potential

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transplant recipient and his or her

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family.

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These evaluations usually centered upon the

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relationships within the family and how the individuals

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concerned had adapted to stress in the past

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Because of the limitations of both funds and personnel.

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During the 1960s,

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selection of potential transplant recipients as well

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as those who were placed on maintenance to analysis presented

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unique problems to those involved in the care of

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these patients.

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Every effort was made to maximize the effective use

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of the limited resources.

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The result of this was that committees of physicians found

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themselves in the unenviable position of deciding

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whether or not patients would be admitted

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to these limited facilities and realizing

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that these decisions were ones of life and death,

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Fortunately expanded federal funding funding since

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1972 has saved physicians whose

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primary commitment is to saving lives from having

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to decide whose life is more worth saving.

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The need for psychiatric involvement with

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transplant patients has not ended.

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Despite efforts to select out of population

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of transplant candidates who were not psychiatrically

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diagnosable,

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the clinical material that has accumulated from

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these patients indicates that they do produce a

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wide range of psychiatric symptoms.

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It's not difficult to imagine that this

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population might have some difficulty

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adjusting to the transplant experience.

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It is difficult to imagine.

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Let us consider for a moment the experience of the

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transplant recipient.

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Prior to transplantation,

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the recipient is in a 10uous emotional state and may have been

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exposed to disturbing neurological or

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psychological manifestations of your premium.

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He's been medically subjected to diets,

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drugs,

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regimens,

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or the cramps and penetration of peritoneal dialysis.

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The discomfort of cancellations is followed by the visible

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external shunt which serves as a reminder of

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his disorder,

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with ensuing fears of infection and our

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exsanguination.

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By the time the patient is ready for transplant,

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he or she may be disheartened by the duration,

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repetitive nature of the hemodialysis,

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by the restriction of physical activities,

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weakness,

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or by complications such as peripheral

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neuropathy,

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renal osteo dystrophy,

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organic brain syndrome.

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He may have had to relocate his residents,

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changed jobs,

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adjust to a lower income,

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altered the basic routines of his life.

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Diet malaise may arise from his

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general physical condition,

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yuri mia treatment and its

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complications and psychological

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innovation.

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We can also imagine that many

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of the adaptations that the recipient must make to his

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life can also be applied to the recipients

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family,

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such as the often necessitated change of residence,

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change of jobs,

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decreased income,

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major illness and member of the family and

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change in contact with social support systems such

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as family,

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friends and organizations.

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When an adult is the affected member of the family,

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These families often operate as one parent

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families.

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And furthermore,

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I believe that we really cannot expect that as routine Ization

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transplantation occurs,

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that this will automatically decrease the stressful effects

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of these events upon the recipient and his family.

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Okay,

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Given we have made efforts in the past to select out

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a population of candidates who are quote

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psychiatrically normal,

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which I believe in essence means that evaluation of

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them did not produce a diagnosis.

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This has failed to prevent the development of

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psychiatric symptoms among this population undergoing

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this experience.

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Are we like to conclude then,

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that the experience of transplantation was productive of the symptom

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Atallah gee.

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There's no direct answer for this in the transplant

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literature.

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If,

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however,

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we turn to the literature on stress and particularly that

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literature,

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which is related to recent life events,

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we can find suggestions of an association

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between stressful events and later symptom.

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Atallah Gee Homes and Ray at

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Washington University of Washington began their work by

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studying a wide variety of

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physiologic and psychiatric

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patients in a retrospective fashion,

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they found a very significant portion of them had a

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clustering Stressful life events

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which occurred during the 12 months prior to the

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onset of their illness.

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Now,

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I've passed out a handout,

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which,

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if you look over briefly,

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um,

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is one of the instruments developed by Homes and

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Ray and I think you'll see when

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you look at it,

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that it refers to

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relatively universally understood series of

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events that may happen

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to any of us,

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even when Homes and Ray controlled for

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socio economic status,

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race,

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multinational effects,

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they were still able to show a remarkable consistency and the

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amount of stress that people perceive these events is

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causing.

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They've empirically assigned values to them as a

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result of their research.

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And you can note that these values are on the left

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hand column beside the events.

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Uhh,

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They've also used this instrument to prospectively

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study a wide variety of

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populations and patients,

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including cardiac patients,

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cancer patients,

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diabetics,

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and normal populations such as college students and

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naval personnel.

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What the results demonstrate is that for

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individuals who accumulate 200 or more

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points,

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Uh,

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during any 12-month period is significantly greater

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proportion of the population will develop an illness

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than when you compare it to populations who don't have

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this clustering of events.

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Why do some people develop illnesses a response to

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stress and others don't?

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I'll return to this in a minute.

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But I think it might be helpful if we briefly

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consider our potential transplant

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recipient and his family history

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that's not untypical for a military family would

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be that the mother would develop chronic renal failure,

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leading to the decision to place her on

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dialysis while awaiting transplant.

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She's transferred to a regional medical center and initially she

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and her family are separated.

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But finally,

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her husband arranges a transfer.

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The wife who was formerly employed is no longer able to

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work.

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The family is contacted about the possibility of donating

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screening proceeds and one sibling volunteers.

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after considerable discussion with his wife but

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nonetheless remains steadfast in his decision to donate

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his time away from his business,

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both for testing and finally,

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for the donut effectively means a loss of income for

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him.

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The recipient following transplant,

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which goes successfully reports upon her return home

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of fear and avoidance of sexual intercourse.

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Well,

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if you look at the recent life change questionnaire,

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I've noted down a code beside these events,

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which is fairly simple.

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Mind that are is for recipient Fs for the

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family members of the recipient and ideas for the donor.

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The events and just the events surrounding the

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transplant experience in the lives of these people

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Has already given both the recipient and the

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members of that family more than their quote

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necessary,

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unquote 200 points.

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The donor himself has also managed to accumulate almost

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2/3 of the necessary points.

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What I believe is clear,

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then,

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is that our hypothetical family

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does endure a stress that is real,

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and one that can legitimately concern us

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to return them to the earlier question of why do some

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people show an association between this

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clustering of events and the disease onset and

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others do not?

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Again,

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we can't answer this directly from the transplant literature.

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We can look elsewhere,

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though,

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and,

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for example,

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to the work of George Engel and his group at Rochester,

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who have described the complex of

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affects which precede the

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onset of illness,

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which they described as the given up giving

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up syndrome.

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The essential point of this concept is that in

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a wide variety of patients that they

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interviewed after the illness experience,

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they found that

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by and large the majority of these patients had an

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experience which was characterized by a significant loss in their

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life,

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which was described to the feeling of being given up

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upon or hopelessness and that was

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followed by a feeling of helplessness or

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having or they themselves giving up.

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They point out that this is neither necessary nor sufficient

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condition for illness onset,

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but it is significantly associated with it.

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Another study by knuckles at all at

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UNC looked at the complications of

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pregnancy,

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they administered a life change questionnaire similar to the

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one I've passed out and found that

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it of itself was not predictive of

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who would and would not

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suffer from complications of pregnancy.

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However,

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when it was combined with another instrument,

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which measured the social assets

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of the individuals in the study,

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the two instruments together combined to

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achieve significant predictive value.

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In other words,

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if we look at both the events which occur in a person's life,

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which require adaptation to cope successfully with

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them,

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and we look at the assets that a person has in the social,

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in social terms,

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uh,

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that they can rely upon for support in these

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situations,

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we begin to have a handle upon who might and who

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might not develop illness as a response to these

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events.

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What is meant by social assets or social supports or

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social adjustment or social networks

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in brief and simply these terms are used to

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describe the adequacy of various

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fears of a person's social world

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means work.

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It means that social leisure life and his

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family means his marriage,

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sexuality and furthermore,

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these are areas of a person's life that we are

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able to assess with instruments that are currently available.

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So given this assemblage of research findings,

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what clinical applications can we make from them?

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Well,

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one view might be to simply

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to develop a massive federal program

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to remove all the stressful events from a person's life.

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Obviously that's impractical.

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2nd view might be to ask

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if it's possible for us to provide

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temporarily increased social support for

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people undergoing stressful situations.

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Uh,

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for example,

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the death of a spouse on the homes and Ray

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questionnaire is the most stressful event

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to occur to an individual that

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widows and widowers often die shortly after the

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death of their spouses.

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Well known folklore,

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I believe that the death rate among

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widows and widowers uh

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rises far above that of a comparable non

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widowed population is a demonstrated research

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finding that widows and widowers who adapt

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badly to the death of their spouse

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have perceived their environment.

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And I think what we can do here is read social supports

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as unsatisfactory as another demonstrated

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finding in response to these facts,

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Widow the widow programs have been developed to provide increased

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social support to this group.

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Simply,

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they provide contact with a wide range of

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services for the newly widowed by previously widowed

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women who have successfully adapted to this

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experience.

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Do we know that such programs make a demonstrable difference?

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Well,

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anecdotally we do,

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but not in a rigorously tested fashion as of yet.

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Similar anecdotal evidence is reported for supportive

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programs for a variety of patients,

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including transplant and dialysis

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patients.

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Um The critical element though appears to

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be that the support is obtained from a

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person who is newly undergoing this stressful

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event from someone who has successfully

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adapted or coped with the situation.

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In the past we cannot provide families,

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marriages etcetera for our patients in order,

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they particularly require that.

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But what we can provide them with is a social support of these

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self help groups.

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While we await more vigorous testing of such services.

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Do we have any indication that providing social supports

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for transplant patients?

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Matters Well,

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perhaps we do.

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A study by Kaplan d'Honneur of seven

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rental units showed that even when a

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research team and the clinical teams

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agreed about the criteria for evaluating the

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adjustment of their patients,

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which were essentially three criteria compliance

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with diet,

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rehabilitation and emotional condition.

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There was a considerable discrepancy between groups about the

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actual evaluation.

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one Group of clinicians and the research group

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fairly closely agreed about their evaluations of the

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patients.

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However,

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another clinical group um

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rated their patients as doing far better

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than the research group did.

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And furthermore there,

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their patients were rated as not doing as well

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as when there was a matchup

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between the research and the clinical

14:20.330 --> 14:20.850
groups.

14:21.740 --> 14:22.490
So in other words,

14:22.500 --> 14:24.550
to state that again,

14:25.240 --> 14:28.230
when it appears that the clinical team

14:28.270 --> 14:30.850
was evaluating uh

14:30.860 --> 14:33.530
adequately and realistically the adjustment of their

14:33.530 --> 14:34.100
patients,

14:34.100 --> 14:36.920
their patients seem to do better than when there was an

14:36.920 --> 14:39.740
unrealistic evaluation by the clinical

14:39.740 --> 14:42.540
team and those patients did not do as

14:42.540 --> 14:42.950
well.

14:43.440 --> 14:46.430
What explanation for this are we left with there to

14:46.430 --> 14:49.020
basically one of which is that

14:49.030 --> 14:51.500
one set of clinical teams had bad patients

14:52.040 --> 14:54.870
and the fact that their patients didn't do well lead to a

14:54.870 --> 14:57.260
development of denial among the staff members.

14:58.140 --> 15:00.990
The other explanation and the one I think is more accurate

15:01.000 --> 15:03.960
is that the denial by the staff members of the

15:04.340 --> 15:06.920
accurate adjustment that their

15:06.920 --> 15:09.900
patients were making led to the patients not

15:09.900 --> 15:11.160
doing as well as they might.

15:11.840 --> 15:13.850
And it's not proven which is really the case.

15:14.160 --> 15:16.880
But other studies of the same group of patients shows that

15:16.880 --> 15:19.620
denial by the staff of their condition

15:19.620 --> 15:22.440
leads to delivery by the

15:22.440 --> 15:25.270
staff to the patients of pat reassurance and

15:25.270 --> 15:26.260
everything's gonna be okay.

15:26.260 --> 15:27.360
You don't have anything to worry about.

15:28.240 --> 15:31.140
Which in turn leads to a decreased reporting

15:31.140 --> 15:33.550
of symptoms by the patients to their doctors.

15:34.340 --> 15:35.390
This is in essence,

15:35.390 --> 15:38.210
as I see it are closing off of an important social support for these

15:38.220 --> 15:38.810
patients.

15:40.040 --> 15:40.860
In summary,

15:40.870 --> 15:43.000
I believe they have demonstrated that we have accumulated.

15:43.000 --> 15:45.510
Clinical evidence suggested that the stressful event of

15:45.520 --> 15:48.320
transplantation and lives of non psychiatric

15:48.330 --> 15:51.050
population often produces psychiatric

15:51.050 --> 15:51.360
symptom,

15:51.360 --> 15:52.050
Atallah gee.

15:52.060 --> 15:52.850
Furthermore,

15:52.850 --> 15:55.540
the stress of this event is not only isolated to the

15:55.550 --> 15:58.060
potential recipient but also includes his

15:58.060 --> 15:58.660
family.

15:59.440 --> 16:00.010
Because we,

16:00.010 --> 16:00.700
as physicians,

16:00.700 --> 16:03.180
have control of this massive intervention in the lives of our

16:03.180 --> 16:03.720
patients.

16:03.730 --> 16:06.670
It is reasonable that we assume responsibilities for

16:06.670 --> 16:09.600
Ameliorating the deleterious effects of this event as

16:09.610 --> 16:12.260
best we can to accomplish this,

16:12.260 --> 16:14.470
we can provide for our patients what they need,

16:14.480 --> 16:17.220
which in almost all cases is not massive,

16:17.230 --> 16:18.860
personality modification,

16:19.340 --> 16:22.220
but rather temporarily increased social supports to

16:22.220 --> 16:24.760
them and to their families in order to help them adapt

16:25.140 --> 16:27.010
to the stress of this series of events.

16:27.440 --> 16:30.280
Such services are easily within the means

16:30.290 --> 16:32.980
of any center providing transplant facilities.

16:33.540 --> 16:36.180
These programs do not need to be slavishly forced upon the

16:36.180 --> 16:36.750
patient's,

16:37.030 --> 16:39.840
but rather utilized as the model present in the widow.

16:39.840 --> 16:42.640
The widow programs in which a wide range of services

16:42.640 --> 16:45.350
and contact is offered to the individual,

16:45.840 --> 16:48.570
but participation and utilization is then

16:48.570 --> 16:50.460
determined by the individuals concerned

16:51.640 --> 16:54.600
psychosocial aspects of hemodialysis and

16:54.600 --> 16:56.070
kidney transplantation

16:57.940 --> 16:58.890
with peter bridge,

16:58.890 --> 16:59.280
Captain,

16:59.280 --> 16:59.970
United States,

16:59.970 --> 17:00.950
Army Medical Corps,

17:00.950 --> 17:02.300
Department of psychiatry,

17:02.300 --> 17:04.080
Np Division walter reed,

17:04.080 --> 17:07.000
Army Institute of Research walter reed Army Medical Center

17:07.000 --> 17:07.730
Washington D.

17:07.730 --> 17:08.350
C.

17:10.140 --> 17:13.020
Was produced through the mobile facilities of the television

17:13.020 --> 17:13.590
division,

17:13.760 --> 17:15.270
Academy of Health Sciences,

17:15.270 --> 17:17.810
United States Army Fort Sam Houston

17:17.810 --> 17:18.490
texas.
