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Let me speak of the future a moment.

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I think that the optimism that is so essentialfor success in science is as indelible as

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ever.

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The future will require more of us than inthe past, it always does.

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It means we'll have to have sufficient flexibility,while sustaining the best traditions to adapt

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to level funding--level funding at best, perhapsfor a few years, perhaps modest compression--as

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increases in the budget, which will come,may fail to meet the demands of inflation.

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I've already made references to adjustmentsof balances in the Intramural Program.

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The next decade is going to test the Institutesas never before in terms of their corporate

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responsibilities.

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It must begin with aggregate budget distributions,and not end with them, as merely the sum of

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competitive independent programs, categoryby category.

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It's going to be a time of tough selectionof priorities for funding by the different

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mechanisms that we have and possibly the creationof new ones for the future.

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Especially, we're going to have to all showcontinued creativity and adaptation in continuous

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adjustment of the balance between categoricalobjectives "part of that genius of NIH" and

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the necessary communal provision of resourcesto maintain the strength of the institutions

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in which the majority of scientists in thiscountry still work and teach.

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We're going to have to have continued attentionto the style, if that be morality, and to

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the substance of activities other than experimentalwork; activities by which NIH also merits

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high rating as a social institution.

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These include: continued provision of technicalconsensus and objective evaluation of technologies;

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education for both the providers and the recipientsof health care so the changes in scientific

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knowledge can beneficially affect the livesof as many people as possible and the practices

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of the professionals.

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We're going to have to keep up that faithfulcuratorship of invaluable collections of data

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and the tangible collections of objects (cells,mutants, and what have you) which join us

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to proceeding generations and will join usto the future.

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We're also going to have to maintain a rigorousdefense of scientific ethic, and of scientific

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freedom, for they are inseparable.