Hello. My name is jean Lloyd and I'd like to show you some of the problems associated with sulfur residues and swine. And then to tell you about some of the solutions as I view them so far amid residues do present large problems for the pork producer. Records from the meat and poultry inspection program of the U.S.D.A Show that during 1976 there were 433 violations involving drugs and pesticides and swine. With 409 or 94.5% being so far inamed's And other species, there were 1410 total violations with 733 or 52% being so fun amid predominantly in poultry. The FADA has established an allowable limit in tissues of 0.1 parts per million and by tissues we're talking about muscle, liver, kidney, eggs, milk and in chickens skin. The FADA has also established a human safety factor of at least 2000. This means that 200 parts per million can be fed to Both rats and dogs for 90 days without causing problems. Some sources of swine soften amid residues are First feed contamination. Second, water contamination. Third, excreta And four lowered water intake. Number five is a theoretical problem in Pigs. Are they different are their hang ups and pigs? Some causes of tissue residues are ignorance of aeration, some farmers don't know they're actually feeding so far. Inamed's Number two mistake by the farmer or the feed mill three disregard for withdrawal times. This is probably the most common cause of residues Number four contaminated equipment and this is probably the most problematical cause of residues. Number five contaminated water six contaminated feed ingredients. This includes corn, soybean meal or pre mixes. Number seven dirty feeding floors, Number eight Hogs following cattle being treated with so far. Inamed's Number nine unapproved use. This is true of many other drugs. In addition to soften the mids. Now, some producers don't read the label and it's true that a label must accompany each delivery of feed. Even bulk feed This feed contains .04, or 440 parts per million sulfur magazine. Looking on the back of the label, we see that there is a five day withdrawal period for this feed. Another feed uh, also contains .044% or 440 parts per million. And if we look on the back of this label, we'll see that there is a seven day withdrawal period. Only sulfur meth, a zine and sulfur are approved for use in swine rations along with antibiotics and at the level of 100 g per ton or 110 parts per million. Now, veterinarians can prescribe any drug which they can legally purchase And in order to increase the efficacy. Some veterinarians have prescribed levels of 800-1000 g per ton or a continuous use in swine rations £20 of a normal cell phone amid containing rationing mixed in one ton of so called clean relation will give 1.1 part per million in the finished rations Contaminated equipment and mixing some therapeutic rations in clean rations will easily result in levels of 2-10 parts per million. And I postulate that so phenomenal levels of less than five parts per million will cause residue problems without withdrawal. This chart shows how sulfur methods seen decreases in swine tissues after withdrawal. We see that at zero days without any withdrawal, all tissues are above tolerance limits of 1/10 of a part per million at five days to critical tissues, liver and kidney still are above tolerance limits And it takes seven days for all tissues to be reduced to .1 part per million dosages also influence influence withdrawal periods. And we see that at the level of 100 g per ton or 110 parts per million, That we need a 5-7 day withdrawal period. If we increase this dosage to 330 parts per million or 10 mg per kilogram of body weight, we see it takes 8 to 9 days withdrawal At at Therapeutic levels. That is 100 or 1000 g per ton or 1100 parts per million. We increase the withdrawal time to 10 to 11 days. And if we increase the dosage to full therapeutic levels, one grain per pound of body weight or 66 mg per kilogram. We find that it takes 10 to 13 or more days except for the failure to withdraw. I feel that farm grinder mixers are the greatest cause of problems. Here we see a typical mixer used on the farm and in this shot we see feed left in an intake order. This is a picture of the premix intake where micro ingredients are added and we see that they are bridged on the sides. Here we see feed left in the conveyor auger of the grinder mixer and here we see ingredients have accumulated under the lid of the grinder mixer to be left there to contaminate the next batch of feed. Looking down through the top of the mixer, we saw what we considered to be about 20 lbs of feed left to contaminate the next batch of feed. This is another brand of a grinder mixer. And here we see feed left in an intake auger and again micro ingredients bridged on the side of the hopper and feed again in a conveyor order. He'd left in a discharge order. And you'll note here that this particular grinder mixer does have a cleaning ports where this bottom of this mixer can be cleaned up a third type of a grinder mixer and we see feed left in the intake auger and there's another problem here, Not only is there feed left, there's a mold problem, potential mold problem with this particular case. Here we see contaminated premix hopper and so far no meds, like some other drugs, notably not Raffarin's are electrostatic and do tend to accumulate on equipment. Another problem area, looking through the top of this mixer portion of the grinder mixer, we saw what we estimated to be £60 of feed left to contaminate the next batch. Now this is an excellent way to clean out augers in my estimation and I might add that the waste is recoverable to add to the next batch of of medicated feed. Poor housekeeping was evident in this farm. Uh and here we see a bulk tank that was contaminated and we did not know whether contamination was due to bridging in the bin or due to the fact that the feed company delivered contaminated feed. Here, we see three possible problem areas. We see a bulk tank, we see the auger elevator and the feed wagon. This is an ideal situation where we have to bulk bends, one that contains medicated feed and one that contains non medicated feed with a posted warning. A feed company bulk trucks pose only a slight problem. This picture shows a conveyor that dumps feed into an auger in emptying this truck. The algerian. This truck contained a very small amount of feed The Auger and another truck that we investigated must have contained 2-5 lbs of feed. Now this level still is very low When you consider that these trucks do contain a large quantity of feed. Most bulk trucks contain a clean out ports Is illustrated here contaminated feeders pose a big problem. This so called clean feeder actually did contain some feed. This that type of water is used for medicating drinking water and heard medication. And they should be this. Any water similar to this should be completely cleaned out and rinsed before using non medicated water. Pigs have a habit of washing down their food and will contaminate this type of water and the surrounding floor. Note the food in the bottom of this water. Another type of water that incidentally can be readily cleaned out. This is a nipple water air watering device that affects the lowest contamination, frequent cleaning of feed floors will reduce the residue problems. Analysis of this manure pile showed that it did contain so far. Inamed's well concrete serve as a reservoir. We don't know but we're checking in this picture. We see dr trey bush of the U. S. D. A. And Dr Thompson and Iowa practitioner sampling concrete in summary to prevent residues of Silvana meds and other drugs as well. We should first read the feed tag. Each tag should indicate that that feed contains the cell phone amid and the level of the cell phone. Ahmed It should also have a warning relative to the use of that feed and it should indicate what withdrawal period is necessary when this feed is being used as we said before. Common withdrawal periods range from 5 to 7 days. And if therapeutic levels of cell phone um IDs are used Then we should be using withdrawal period of 10-13 days. Secondly we should clean the feeders and the equipment. We see here that this bulk feed truck does have a ports and can be cleaned out in this shot. We see that the grinder mixer as support and can be cleaned out. These should be cleaned out physically mechanically followed by the use of the large shop vacuum sweeper. Of course we should withdraw water medications and injectables and injectables amount to about 20% of the actionable residues of drugs in edible tissues. Of course we talked about cleaning feed floors. We see here a feed floor that has been clean and this should be especially done at the time. Animals are being marketed and being withdrawn from self inamed's And of course as we said before we should withdraw therapeutic diets longer, probably 10-13 days. Lastly but not least we should refrain from the unapproved usage of drugs. In conclusion, in order to solve or at least reduce the problems associated with drug residues. It's going to take the cooperation of the feed company, the farmer, the U. S. D. A. And the practicing veterinarian