28303.  Adulteration of tincture of nux vomica, camphorated tincture of opium, 
elixir terpin hydrate and codeine, elixir triple bromides, and Fowler's 
solution.     IT. S. v.   Goodrich-Gamble Co., Inc.    Plea of guilty.    Fine,. 
$25.     (F. & D. No. 38598.     Sample Nos. 63326-B to 63330-B, incl.)
These products were sold under names recognized in the United States 
Pharmacopoeia or the National Formulary but differed from the standard 
established by those authorities, and with the exception of the Fowler's solution, 
they differed from their own declared standard, since they were found to con- 
tain certain drugs either in greater or smaller amounts than those declared
On April 6, 1937, the United States attorney for the District of Minnesota,, 
acting upon a report by the Secretary of Agriculture, filed in the district court 
an information against the Goodrich-Gamble Co., a corporation, St. Paul, Minn., 
alleging shipment by said company in violation of the Food and Drugs Act on 
or about May 4, 1936, from the State of Minnesota into the State of Wisconsin,, 
of quantities of the above-described drugs, which were adulterated. They 
were labeled in part: "Goodrich-Gamble Company, St. Paul, Minn."
The articles were alleged to be adulterated in that they were sold under 
names recognized in the United States Pharmacopoeia or in the National 
Formulary and to differ from the standard of strength, quality, and purity as 
determined by the tests laid down in those authorities in the following respects:. 
The tincture of nux vomica yielded not less than 0.303 gram of the alkaloids of 
nux vomica per 100 cubic centimeters, whereas the pharmacopoeia provides that 
tincture of nux vomica shall yield not more than 0.263 gram of the alkaloids 
of nux vomica per 100 cubic centimeters; the camphorated tincture of opium 
contained not more than 3.42 grains of powdered opium per 1,000 cubic centi- 
meters, whereas the pharmacopoeia provides that camphorated tincture of 
opium shall contain not less than 4 grams of. opium per 1,000 cubic centimeters ; 
the elixir terpin hydrate and codeine contained no codeine, whereas Sen- 
sational Formulary provides that the product shall contain codeine; the 
elixir triple bromides contained not more than 45.6 grams of ammonium 
bromide, not more than 44 -grams of potassium bromide and not more than 
51.9 grams of sodium bromide per 1,000 cubic centimeters; whereas the National 
Formulary provides that elixir of three bromides shall contain in 1,000 cubic- 
centimeters not less than 80 grams each of ammonium bromide, potassium 
bromide, and sodium bromide; the Fowler's solution contained not more than.
0.854 gram of arsenic trioxide per 100 cubic centimeters,, whereas the pharma- 
copoeia provides that Fowler's-solution, namely, solution of potassium arsenite 
shall contain in each 100 cubic centimeters not less than 0.975 gram of arsenic 
trioxide; and the standard of strength, quality, and purity of the articles 
was not declared on the containers thereof.
With the exception of the Fowler's solution, they were alleged to be adul- 
terated further in that their strength and purity fell below the professed! 
standard and quality under which they were sold, since the tincture of nux 
vomica was represented to conform to the pharmacopoeial standard and to- 
contain in each 100 cubic centimeters 0.1 gram of strychnine, whereas it was 
not tincture of nux vomica of the pharmacopoeial standard and each 100 cubic 
centimeters contained more than 0.1 gram, namely, not less than 0.155 gram 
of strychnine. The camphorated tincture of opium was represented to conform 
to the pharmacopoeial standard and to contain in each fluid ounce 1.9 grains of 
opium, whereas it did not conform to the pharmacopoeial standard and each 
fluid ounce contained less than 1.9 grains, namely, not more than 1.56 grains 
of opium. The elixir terpin hydrate and codeine was represented to conform 
to the formulary standard and to contain in each fluid ounce 1 grain of codeine 
sulphate, whereas it did not conform to the formulary standard and each 
fluid ounce contained less than 1 grain, namely, not more than 0.85 grain of 
codeine sulphate. The elixir triple bromides was represented to contain in 
each fluid drachm 3 grams each of potassium bromide and ammonium bromide, 
whereas each fluid drachm contained less than so represented, namely, not more 
than 2.51 grains of potassium bromide and not more than 2.60 grains of 
ammonium bromide.
On April 6, 1937, a plea of guilty was entered on behalf of the defendant 
and the court imposed a fine of $25.
HARRY L. BROWN, Acting Secretary of Agriculture.