Jno L Price
$13.75
10.00
1.50
$25.25 [W G B Lue]
1.00 cn
24.25
10 add
$34.25 [W G B lue]
[W B Due]
[W B Due]
[W B Due]
Presented to [J M C] Irwin by his
preceptor Dr J L Price
March the 18 1830
Jessamine County 
Kentucky


Lexington Novr 10th 1823 Lecture 1st.
Dr Dudley
Of the terms used in the articulation of bones.
Ano first of the symphysis, by which is meant
the connection of bones by intermediate 
substances. Thus there are three species of 
emphysis noticd viz.
Synchondrosis, when bones are connected 
to such other by cartilage; as the ribs 
and sternum.
2d Synneurosis, when they are connected 
by ligaments, as in the movable
articulations.
3d Syssarcosis, when they are connected
by muscle; as the ostyoides.
The different articulations are of two kinds
viz synarthrosis and diathrosis 


1st Synarthrosis is the name of that kind 
or articulation which does not admit of’
motion. There are three species of synarthrosis
1st Suture, when the indented edges of the two 
bones are received into each other, as is the
case with the bones of the cranium.
2d Gomphosis, when one bone is fixed in
another, as in the teeth in their sockets.
3d Schindylosis, when the thin edge of one
bone is received into a narrow furrow of 
another, as the nasal plate of the [??moid] in the vomer.
2d Diarthrosis is the name of that kind 
of articulation, which admits of motion.
of these articulations there are three species 
1st Enerthrosis, when a large head is received 


in a deep cavity, as the head of the thigh
bone in the acetabulum.
2d Arthrodid, when a head is connected 
with a superficial cavity; as the head 
of the humerus with the glenoid cavity of
the scapula.
3d Ginglinus, when the extremities of bones
apply to each other so as to form a hinge,
as the tibia & femoris.
Dr Blythe. Nov. 11th 1823. Lectre 2d.
Of Attraction
1st Attraction of granulation, it is the principle
which operates throughout the universe.
2. Attraction of cohesion is that power by 
which bodies of similar nature are held together
3d Attraction of electricity. In an operation
of an extremely subtle fluid body, pervading all bodies 


Bodies are sometimes in a positive and sometimes
a negative state of electricity: bodies
a different state of electricity approach each 
other; bodies in the same state of electricity [refe??]
each other
4 Attraction of magnetism is the special 
attraction by which the loadstone is affected
and has nothing to do with chymistry. That
kind of attraction which the chemist is [interested]
in the attraction of composition, or [chemical]
affinity. The attraction of cohesion, or aggregation
exists between particles of the same kind 
Attraction of composition, or chemical affinity
exists between bodies of a dissimilar
nature, the union of which form a substance
entirely different from each of the [two]


Cathartics medicines are those substances which
quicken & increase the evacuations from the 
intestines by stool. We are told that medicines
of this class have been employed by physicians
since the first dawn of physic; and have
[been] administered with various views and intentions
according to the prevalent theories of
the time, or the favourite doctrines of individuals.
I shall say 
nothing of
tenets of the judicial astrology who
prescribed purgative at certain times and seasons,
conceiving that they would prove more
beneficial or hurtful, according to the junction
or apposition of the planets, or a great 




moon, but [illegible] to more modern
times Modern physicians have two objects
in view in the administration of cathartic
medicines; the one is to empty the bowels simply 
or to bring off thin contents, which are out of the
course of the circulation, and therefore already,
in a manner, extraneous to the body;
the other is to excite an increased secretion
of fluids into the cavity of the intestines, or, 
in other words, to induce purging. Tho 
medicines thus employed have generally 
been assorted into two classes: those which 
produce the former effect, being denominated
laxatives, and those conducing the latter,
purgatives. The operation of a purgative medicine 
on the intestinal canal may be 
considered 




as three fold. In the first place, it stimulates
the muscular fibres of the intestines, quickens
their action, and therefore augments the 
natural peristaltic motion of the bowels, by 
which means their present contents are more
quickly propelled and discharged Secondly,
it stimulates the [illegible] vessels, which 
terminate in the inner coat of the intestines,
and excites them to pour out a more 
copious discharge of fluids; and also the 
mouths of the excretory ducts of the
musous glands, by which the natural
mucus of the intestines is much increased,
and hence the evacuations by stool are
not only quicked, but the foecal matter
is thinner and more abundant.




and, thirdly, the stools are rendered still 
more copious, by an additional portion of 
the fluids furnished by the neighboring
viscera, the liver, pancreas, etc. to which 
the stimulus of a purgative, especially of
the more active ones, extends. These effects
are probably communicated to the whole
range of the intestinal canal, from the
upper orifice of the stomach to the lower 
extremity of the rectum.
From this view of the immediate effects
of cathartic medicines upon the intestines,
their utility in some diseases, and their injurious 
tendency in others, as well of the necessity of 
varying their degree of activity, under different
circumstances, will be readily understood


If we consider the great length of the
alimentary canal and the number of 
vessels and mucous follicles, as well as
the large ducts from the liver and 
pancreas, which open upon its inner
surface, it will b obvious that purgatives
even if a moderating stimulating
power, by opening at once all these 
outlets, may occasion a great general
evacuation and diminution of the
fluids of the body. Hence, in acute 
inflammatory diseases, where overdistention
of the vessels is to be [avoided], 
& the preternatural increase of the active
powers of the septem is to be restrained,
the evacuation of the intestines by 


purging is (next to bloodletting) the most
powerful expedient, and generally makes
an important part of what is called the
cooling or antiphlogistic plan of treatment.
When purgatives are given with this intention, 
however, the principle must be 
pursued with some limitation, and those of 
the most acrid and drastic nature must
be avoided, because the diminution of 
general stimulus produced by the depletion 
of the vessels, and the expulsion of the
faeces, would be counterbalanced by the 
extraordinary irritation of an acrid purge.
Another circumstance apparently 
results from the evacuation by purging,
which renders it of considerable importance
in particular diseases; namely, a 


change in the distribution the 
blood to different parts of the system
It seems to follow, of necessity, that
if an evacuation be made from one
set of vessels, the [afflux] of fluids to 
these will be increased in order to 
supply it, and, consequently the afflux
to other parts of the system will be 
diminished. Upon this principle, Dr Cullen
explains the utility of purgatives in 
disorders of the head, which arise from 
over fullness or over activity of the vessels 
of the brain; such as apoplexy, and
other comatose affections, mania,
phrensy, headache, etc. The afflux 
of fluids in the vessels of the abdomen
which supply the intestines, being 


increased by purging, the afflux will
be proportionally diminished in the vessels
which carry blood to the head, and both
the quantity & impetus of the blood in 
the head will be lessened.  (Cul. M.M. VII)
In the same way he partly explains
the good effects of cathartics in the small
pox, and other cutaneous diseases, from the
balance of the distribution of the fluids
between the internal parts and the external
surface. But it is probable
that they are more useful by removing the
local [illegible] of the faeces, and occasioning
a considerable depletion, and a
consequent diminution of fever in the 
system at large. for in diseases of 
the skin, unconnected with fever, 



their good effects are very inconsiderable.
Whenever the contents of the
intestines are morbidly retained, whether 
in consequence of a slowness of the peristaltic
motions, from a [tortor] of the moving 
fibres; or from a laxity of the intestines,
which permits the faeces to accumulate;
or from a deficiency of bile; or from 
habitual neglect of regular evacuations;
the use of cathartics of one kind
or the other is indicated, in order to 
prevent to accession of more serious complaints
which will ultimately result 
from the costiveness. The nature of the 
cause, or the concomitant circumstances
will point out the particular
sort of medicine, which may be
most 


appropriately employed. If the costiveness,
for instance, be accompanied with
a flaccid habit, or weak symptoms of 
nervous mobility, or much flatulence
and irregular distention of the bowels,
some of the warmer aromatic
laxatives should be administered.
if the secretion of the bile appear to 
be deficient mercurial & aloetic medicines,
the latter of which tend to supply 
the deficiency, and the forms to restore
the bilious secretion, should be prefered.
In those cases, however, in which 
the morbid retention of faeces is not
habitual, but accidental, and accompanied
with some more acute
symptoms 


i as with violent pains, constituting
the colic; with pain, tenesmus, & 
slimy or bloody stools, as in dysentery;
or with acute fever, as in inflammation
of the bowels; cathartics,
though absolutely necessary, must
be varied in their nature & mode
of administration, after a cautious
view of the circumstances.
In colic, for example, the will be 
of little advantage in many cases, & 
more especially in the colic produced 
by [lead], until the painful spasmodic
constriction of the bowels
has been relaxed by the previous
use of opiates. In dysentery,
they must be combined or 


alternated with opiates, otherwise the
irritation which they occasion, in that
tender state of the intestines, will counterbalance
the effects of the evacuation,
and keep up the symptoms of the
disease. [illegible] in enteritis, or inflammation
of the coats of the alimentary 
canal, the same irritation 
will tend to increase the inflammatory 
action, and the consequent
constriction, and therefore impeded
rather, than expedite, the excretion 
of the foecal matter, if they be 
employed before blood letting and
other remedies have [illegible] the
inflammatory state. In a work
published by 


Dr Hamilton of Edinburgh, a degree 
of importance is assigned to cathartic
medicines, in the treatment of 
several diseases, which they have not
hitherto been considered as entitled to,
of which deserves to be mentioned.
Independently of the generally 
admitted opinion, that a loaded and
constipated state of the intestinal canal
is a common cause of general bad
health, he maintains, that this state 
usually accompanies and aggravates 
the other symptoms of fever; & that
it is also the immediate cause, or a
leading and permanent symptom,
of certain disorders peculiar to 
children and young people; 



these are chorea, or St Vitus’s dance,
marasmus; chlorosis, or green
sickness; haematenesis, or vomiting 
of blood; and even hysteria & 
some chronic nervous diseases. In 
these diseases he never uses medicines
in a purging dose; his intention 
being simply to expel the present 
contents of the intestines, and
not to increase the secretions of the
fluids into them. In typhus fever,
he says it is now some years 
since I have left off almost entirely 
the practice of ordering emetics & 
glysters. I trust to a purgative to ensure
a regular [illegible] evacuation 
for this purpose, however, a daily 



purgative is not always required
Thus, I think (says he) I conduct
the treatment of typhus fever to a
favourable issue with more certainty,
and with greater ease & comfort 
of the patient chorea, or St. 
Vitus’s dance has been almost invariably 
treated with tonic medicines,
especially with bark and metalic
preparations, and with various
stimulants and antispasmodics. It 
is unnecessary to say with how little 
effect in general. In every instance
Dr Hamilton has found that a 
large quantity of black and offensive
feculent matter was
collected in the bowels, and 


his plans of cure has consisted
in a regular exhibition of
laxatives, untill the stools assumed
their natural appearance. With this
intention the practitioner must persevere
firmly in his measures, especially in 
the confirmed state chorea, for if he
relaxes he will be unsuccessful.
By this treatment, which consisted in 
giving three grains of calomel, with six,
eight, or ten, of jalap, daily, chorea 
is speedily cured, generally in ten days 
or a fortnight. Another important
operation of cathartic measures
remaining to be noticed, namely, 
the stimulus they exert on the absorbent
vessels, by which these vessels 


are excited to an unusual action,
and thus to take up fluids which
are morbidly effused. The fact is undoubted, 
whatever may be the principles 
on which it is explained. Dr
Cullen, observes, on this subject, that,
as in every cavity of the body there is 
an exhalation & inhalation, or absorption,
constantly going on, it is presumed 
that there is some [illegible]
constantly preserved between the 
secretory & absorbent powers, so that 
if the former are increased, the 
latter will be also; and, therefore, 
that when the secretions are, upon 
occasion, much increased, the 


action of the absorbents may be particularly 
excited. This explains why 
purging often excites the action of the 
absorbents, to take up more copiously 
the fluids that are otherwise stagnant
in the adipose membrane, or other
cavities of the body, & thereby often
proves a cure of dropsy. C. M. M. vii.
p. 502.). This explanation is perhaps 
little more than an explicit statement
of the fact. It is certain, 
however, that ascites, or dropsy of 
the abdomen, has been often affected
by means of acrid, drastic
purgatives, such as gamboge, scammony
etc. when diuretic remedies


have failed.
But it is obvious that these
remedies can only be administered
to those, who retain considerable
strength of constitution,
debilitated neither by inveterate
intemperance, old age, nor a 
long disease.
Johannes Lewis Price
Nov 19th AD 1821 Lexingtonensis
Kentuckiensis AL 5823


the matter expectoration varies much in quantity
and quality and consistence, amounting sometimes
to the [illegible] [illegible] four hours. Coldness
of the lower extremities seldom ceasing
until warm weather accompanying
derangement of the abdominal viscera
When there is great pain in the forehead blood [taking]
is to be used freely. blisters and antimonials, observe
strictly to the antiphlogistic regimen 


croup may be cured by bleeding, purging, emetics
and the warm bath. The bleeding must be regulated
according to the urgency of the symptoms and
the superior judgment of the physicians
Blisters are apt to run into gangrene if they 
should be applied. the best vesication is on the
back. [Brochaety] or tusis [illegible] inflammation 
of the bronchae Dr Hastings [his teaching] great
tendency to spasm and wheezing sometimes fevers 
are present of about three weeks or a month attended
an [expectoration] of purulent matter resembling
hooping cough requires bleeding of 8 or 12 [illegible] two 
or three times with purges of salinic preparations.
sometimes ulcerations of the bronchaei; common 
bronchitis, white tongue, high pulse a difficulty 
of breathing, with violent coughing.


In all diseases where the trachea is the seat
of inflamation there is something like a spasmodic
action of a croupy [diasthmatic] kind
which is generally relieved by the warm bath,
or antispasmodics, such as the tinct. asafoetida
or paregoric elix. [illegible] [vinus] antimonials to
produce diaphoresis. Emetics should ([illegible]
be given.) By frequently washing the necks & [illegible]
of children with cold water, which by familarising 
the system to such impressions, the child
is not so liable to attacks of croup.
Bleeding, warm bath, emetics [with] [illegible], calomel
& sweating, are the remedies for croup. Do not
draw too much blood from children (Bleed
from a large vein & a large orifice, with
the patient in an erect posture.)


irritation from the kidneys, & places it [on]
the bowels. And by a repetition of cal 
produce a salivation, keep it, & the syphillis
will yield. No fruit, or vegetables 
are to be eat.
In those seats of the system where the 
bones are enlarged in consequence of a natural
proportion of lime and phosphoric acid
in which case the phosphate of lime, and 
phosphoric acid should be given.
Brown. MD 15th Jany 1824.
In laryngitis you are not to rely so much on blood
letting, as in other inflammations in the throat.
Emetics, are the remedies which Dr Armstrong
relies on in this disease, they are to be followed 
by antimonials, and cathartics
General Washington died of laryngitis Dr B. thinks
that he was badly treated, his physicians having 
bled him to much & not puked enough


his drink should be toast water, or mild
teas, [diets] should be soups, tea, coffee,
[pomada], no spiritous or vinous liqurs
should be drank Acids of all kinds
should be strictly avoided as they would
produce a derangement of the digestive
organs. (The mercury is to be given 
untill its peculiar constitutions effects 
is producd, which is to be kept up untill
the disease is removed. The ungt is to 
be used as a local application internally in conjunction with the blue
pill. (Externally the ungt. internally the pill.)
Where the mercury passes off by the 
kidneys in form of diabetes, in this
disease, we should purge actively 
with calomel, which draws off the 



on the other hand understand the treatment
of the milder from better than the French.
Muriate of goler, and the mineral acids 
have been highly recommended to cure
this disease. In the summer time it 
is not necessary to confine the patient, but 
in the winter it is impossible to cure him
without [confines] [illegible] Cure The 
blue pill is doses of 10, 12, or 15 grs 
per day
for 12 or fifteen, or 20 days, or untill the
gums are effected by it. Then give the pill
in such quantities, as to keep up the 
effect on the gums. Ungt. Merc. is to 
be used as a local remedy to the chancres 
a rigid course of diet is to be observed 


B W Dudley, M.D. 14th Jun 9, 1824.
On Syphillis. This is a disease of
a specific kind effecting primarily the cutaneous
system, and secondarily the bony, and
every other system. In the year 1490. It appeared
in France, and was called in [contra]
distinction to gonorrhoea. French pox. This
disease is curable without the use of 
mercury. In France this disease is cured
by the corosive sublimate, in all its forms.
The English use of sub. muriate of mercury 
together with unguents men. In the U.S. this 
disease is sometimes cured by caustic.
In the aggravated forms of this disease
the French understand the treatment
better than the English. The English 


Mumps. This disease should be treated by 
cathartics when metastasis has taken
place, to the testicles. Metastasis to the 
brain sometimes take place in this disease
in which case [cathartics], with blood letting
etc. should be used


as in the brain a peculiar power in relieving,
therefore copious depletion by cathartics, with bloodletting,
emetics, and antimonials, followed 
by opiates are the remedies. In Rheumatism,
bloodletting, with continued purging etc.
White Swelling In this disease cathartics 
are indispensable in the incipient
stage. Emetics should be first given, & 
then followed by a continued use o f
cathartics, every other, or every third 
day. Purperal Swelled Leg. After
the administration of emetics, cathartics
in combination with diuretics should 
be given as indispensable 
Hernia Humeralis, or Swelled Testicle 
emetics, cathartics & the warm bath are
the remedies.


Phrenitis, or inflamation of the brain and its
membranes In fevers of the various kinds
an inflamation of this kind is frequently 
excited. It sometimes comes on as a 
primary affection. Notwithstanding it is
produced by different causes, the treatment
is the same. Bleeding in this disease
is certainly an important remedy
yet in consequence of its occurance in 
the decline of fever, when the system is 
too much debilitated to bear bloodletting, it
cannot at all times premised, purgatives
however & particularly mercurial 
are at all times admissible, under every 
circumstances in this disease. Ophthalmia.
In this disease cathartics have, 


D. Drake, M.D. 14th Jan, 1824.
In every derangement of the chylopoietic organs
copious purging is as absolutely necessary 


of the illium, the whole of os sacrum & from the posterior [illegible] ischiatic ligament & [??oygis] [Instd] into the up & [illegible] of linia [illegible]
outer and posterior part of the trochanter major. Use the [illegible] upwds
illium that is not occupied by the 2 former, and [illegible] 
of the trocanter major.
and branches like a tree, and distributed to the 
[illegible] downwards afer passing out of the ischatic in 
glutic muscle and tied up the great glutialatic
foramen. This is the only case on record
or passes out of the pelvis with the posterior crural nerve, below the [illegible]
to be inserted, into the upper part of the cavity at the rt. of the tro: magr
Spis [illegible] & the inferior fn. the [tub] of the ischium, also from the parts [sacrovischc]
[illegible] of the observator interus. [Insd] in to the cavity at the rt of the tro: majr
ischium, & running tranwsversely, & [Ins:] into the ridge extending from the root
trocanter.


induce abortion. Bleeding, by preventing
a determination of blood to the uterus.
B.W. Dudley, M.D. Jany 14th 1824.
1st, Glutius Maximus. or: from the posterior part of the sp
2d, Glugius Medius, or: from the atm sup spes [pro?] illium & from its dorsum inserted into the
3d. Glutius Minimus or: from all the [illegible] of the 
down to be inserted into the
great glutial artery passes out of the foramen ische
glutei muscles. The great nerve takes its dire 
company with the artery.
John Bell. Cut down through the great
artery just where it passes out of the ischi
of the tying of this artery.
4th. 1 Pyriformis. or: [illegible] tendons, the 2d, 3d fourth pieces of the sacrum
the posterior part of the ilium - & runs
5th. 2 Obturator internus. or:
6th. 3 Gemini or: [illegible] heads from, the superior, [illegible[ [illegible]
ligament, [illegible] form a [purse] for the tendon
7th. 4 Quadratus Femoris. or: from the buberosity of the os
of the large to the small
rotators of the thigh onwards


very early period after conception.
which will be 
Abortions are divided into two great
classes 1st for accidents.
2d habit. The latter
deserves our particular attention, and 
profound research, and inquiry into
the mode of preventing it It is induced
perhaps by former miscarriages, by an
imperfect action of the uterus. This 
incompatibility on the part of the uterus, to proper
& regular action takes place internaly
More frequently when they are advanced
in life before they get married,
than in those who marry early! Excessive
venerial intercourse [illegible] the organs 


a very short time, the hemorrhage
is sometimes considerate & sometimes
not. Nausea and sickness is sometimes
distress the patient very much,
at other times very little inconvenience
is experienced The foetus is aborted
alive sometimes. The sign of the death 
of the foetus previous to abortion s a cessation
of morning sickness, [faccidity]
of the mamma, no motion of the 
child, and a heaviness in the region 
of the uterus. Paroxysms of
nausea, with hysteria, fever, uneasiness,
milky discharge from the 
mamma, are symptoms attendant
on the death of the ovum at a 


twin gestation after the expulsion of
one foetus. There is not infrequently 
a suspension of the symptoms for
several days before a recurance of 
the symptoms again when the [other]
is expelled The patient should therefore
be kept in bed for several
day after at accident of this
kind. After detachment takes
place, expulsive efforts will take place 
& consequently abortion in spite of the 
physician. The pains are very severe 
in some cases of abortion, in other 
cases there is very little [induced], sometimes
they continue several hours, at
other times again it is completed in 


the serous discharge which takes place
previous, is now entirely suspended 
Ladies who are in the habit of aborting
three or four times a year,
very little
inconvenience from a process of that kind.
Dr Richardson related the case of a lady 
who aborted in the morning and
went to church on the evening of 
the same day !!! Not unfrequently 
a rupture of the membranes take place
& the foetus escapes with the [illegible]
the placenta & membranes remaining
in the uterus several days.
Sometimes the oven & membranes
are expelled entire. In cases of 


The ovum may be thrown of at different 
periods of gestation. Gestation may 
be suspended before the descent of the
ovum into the cavity of the uterus,
in cases of this kind the patient has
symptoms similar to those of menorrhagia,
or excessive discharge from 
the uterus. from which is should be
carefully distinguished. If a feverish
condition of the system existed previous 
to an affection of this kind, with pains in 
the back etc. with a discharge of a 
considerable discharge of coagula of
blood etc. be particular & do not mistake
coagulated blood for the ovum & its
rudiments. When abortion takes place 






the above symptoms your prognosis
should be unfavourable as they invariably 
die
W. H. Richardson M.D. 14th Jan 7 1824
On Abortion. When the foetus is detached,
and expelled from the uterus
between the sixth & ninth month of utero 
gestation it is called premature labour. when 
the detachment and expulsion takes place
from the first to the sixth months it is called 
a miscarriage or abortion; hemorrhage is the 
consequence of detachment, and espulsive
efforts hasten detachment & 
consequently expulsion viz seperation
of the ovum & contraction of the uterus


croup, & [toncilaris] by its attacking
persons advanced in life and the 
absence of those peculiar whesing 
noise which it can not in croup in 
acute cases.
Bleeding is indispensable in this disease
& must be carried to a considerable
extent. together with a bold & vigorous 
observance of the antiphlogistic plan
with occasional opiates. In chronic
laryngitis commences with hoarsness, 
a tickling sensation in the larynx, & 
a thickening of the membrane lineing the
larynx. with long and deep inspiration,
and a discharge of ropy muccous 
from the throat when children of
a scrophulus diathesis, complain of 
2d vol. of the [illegible] journal of 
[illegible] medicine


It is liable to a metastalous to the
testicles, & the brain, in the latter metastatons
great danger is to be apprehended. In cases of metastations
with then testes or brain. they are 
to be treated as idiopathic inflamations
as no kind of treatment
is known to prevent this strange translation
of this disease The general
antiphlogistic treatment is it
to be followed in the cure of this
disease. Of Laryngitis or inflamation 
of the larynx This disease
comes on in consequence of cold
and is an inflamation of the larynx 
It is distinguished from 


of being of a red colour, it is pathognomic 
of the errisypelatous form of
this disease, in which case it terminates
frequently by vesication. It is important
to distinguish between this form
of cyanete, from the putrid soar throat
Bleeding, scarification of the toncils & 
the antiphlogistic plan, with volatile
linaments to the throat, & occasionally 
blisters, either to the sternum, behind the 
ears, or oven to the throat.
Cynanche Parotida or mumps.
This diseas comes on with a [illegible] fever
with a swelling of the parotid glands 
It sometimes, but seldom [terminating] by 
suppuration of the gland


when the disease is still more violent
a more rigid antiphlogistic plan must
be adopted. Dr. Brown derived
great benefit by keeping his body warm
& [illegible] out in the cool air of the morning,
and drinking freely of cold
water. of cynanche tonsitaris,
this disease is [illegible] appears with imflamation
of the tonsils and throat, etc.
this inflamation frequently terminates 
by a suppuration of the toncils, which 
is of a very offensive smell. persons
subject to this disease in early life, are
uncommonly liable to have it [illegible] 
their life when the inflamation
of of a purple colour, [illegible]


some latent cause in the atmosphere & 
prevailing epidemically. This disease occurs
with a disposition to sneese, with a 
thin acrid discharge from the nose, with 
pain in the head, eyes red, etc. during
the prevalence of this disease bills of 
mortality appear not to be increased
Old people, & those in particular who 
have been subjects of tussis senilas
are its victims. Common catarrh is 
seldom of sufficient violence to demand
the use of medicine, as nature generaly 
throws it off But in the more aggravated 
forms of catarrh, epsom salts, pediluvium,
diluent drinks such as flax seed, antimonials
to excite expectoration etc. but 


Sam Brown M.D. 14th Jany 1824
In inflamatory affections of the system
blood should be drawn from a large orifice,
the patient being in an erect posture.
Drop a small quantity of alkohol or camphor,
rub it fine, and pour on it a small
quantity of warm water, & use it as a 
colyrea.
Of Catarrh. This is an inflamation
of the mucous membrane, of the nases,
throat & fauces etc. which extends frequently 
to the bronchia of the lungs The
most common cause of catarrh is
cold, & frequent vicissitudes in the weather
The influenza is thought to be
a different disease, originating from 


region of the stomach. Bleeding, injections,
blisters, calomel & opium etc. are
the remedies for gastritis
Dr B. W. Dudley.
Cordee in gonorrhoea, are attendant
on that disease, this is always worse
night when the patient is coverd warm
in bed indication opium as much as sufficient
to allay irritation.
Wart. when on the extremity of rectum
or penis. get clear of gonorrhoea & you 
are rid of these troublesome attendants


Erisypalous & Urticaria. In these
disease cathartics are no less indicated
that emetics, & should as in 
fever be employed during every 
stage of these diseases. Apthea
this affection of the mouth, is cured
by laxatives.
Inflamations.
of gastritis, in this disease injections 
should be given [illegible], together with 
bloodletting, for the purpose of subduing
the great irritability of the stomach,
and subduing inflamations
which is to be followed by [illegible]
& if necessary to be combined 
with opium, epispastias to the 


constant exhibition of cathartics, & therefore
they should not be continued as 
long as the alvine evacuations present
appearances of that kind, unless
other symptoms seem to indicate them.
Eruptive Fevers. Scarlatina simplex,
scarlatina anginosa, & scarlitina maligna are
forms of eruptive fevers which we have
frequently to combat, and for our success in 
treating it this disease cathartics are 
remedies which we must employ to 
be successful, & they should be kept up 
during the whole continuance of 
the disease. In measles, cathartic
medicines are [imperiously] indicated;
to be continued pro re nata!


spontaneous evacuations which 
sometimes takes place in fevers
should not prevent the physician from 
giving purgatives, as it often arises from 
irritations which demand the administration 
of cathartic medicines.
No six hours during the period of 
fever should pass, without producing
an evacuation from the bowels.
In intermittents, remittents, [illegible],
& typhus fevers, purgatives are alike
indispensable, and are indeed the only 
medicines that can, & ought to be 
given at all times in the commencement
of these diseases. Morbid
excreta may be produced by the 


every disease. In diarrhoea cathartics 
are indicated for the express purpose of 
exciting purgation, to prevent the excessive
evacuations which take place in 
the [illegible] of that disease They are
indispensable in the beginning of every 
fevers, no difference what may be
its name. In terrible congestions in the 
internal organs, and the powers of the
system greatly prostrated, enemata of 
a powerful and stimulating kind,
to be followed by calomel, jalap,
salts, sennae and other active articles
of a purgative kind They are
to be continued through out the whole
course of those diseases.


the perineal fascia and oposite to the 
rupture of the urethra. The next object
is to remove the stricture if it be
complete, if not enlarge it by the
use of bogees It is necessary to open
the structure where it is complete by a 
lancet, guarded by a tube, or to use
the lunar caustic etc. Even you may 
cut out the structured portion of the urethra.
Dan Drake. M.D. 13th Jan. 1824
Cathartics or Purgatives, This class of medicines are
employed in all the various forms
of fever, they are more useful in 
inflamatory affections that emetics
cathartics are indicated in almost 


inserted in to the crura of the penis
lar substance, & passes around to be inserted anterior to
the ruptured urethra. Fistula in perineo
is produced by various causes. to wit:
1st violence offered to the parts. (nature [illegible])
2. Stricture of the urethra. which is consequence 
of the large distention of the
urethra behind the stricture, the supurative 
& ulcerative takes place and destroys that
canal in part, which admits the urine
to pass into the cellular substance of 
the perineum. Treatment. Make a
free and extensive incision through 


B. W. Dudley M.D. 13 Jany 1824.
1st Erector Penis. or: from the [illegible] ischi. & is
2d Transversalis Tenenci. or:
3 Ejaculation seminis or
4. Constrictor ani. or: from the escape & cells
the rectum.
Fistula in penio, is a rupture of some
portion of the urethra, whereby the urine
escapes and [illegible] its way through the
cellular substance, and discharges itself
through the substance of the scrotum.
The urine effused in under the perineal
fascia which is a dense, firm, and
strong membrane which prevents the 
escape of the urine. The nearest point
of the urethra to the [postulous] opening
is not to be considered as the seat of 




nature employs sulpher in many [other]
operations, she changes with it our
mineral waters, she mineralizes
the metals with it It is used by 
her in the vegetable kingdom. It is
also an agent in the animal kingdom.
It combines in two portions with 
oxygen, forming according to the proportion
with which it unites with the 
oxygen sulphurous, or sulphuric acid, 
sulphuric acid is formed by burning a
large portion of sulphur in a leaden
chamber, it combines with the atmospheric
air, & is absorbed by the water, 
which is again rectified. 


It is also evolved from animal substances
in form of sulphurated hydrogen,
sulphurated hydrogen existed in eggs, as evinced
by immersing a piece of silver into an
egg & its being coloured as if it had been
colourd by sulp hydr.
It is the base of many compounds.
It unites first with 
1. Oxygen.
2. Acids
3. Hydrogen 
4.
5.
6.
7.


Pure sulpher is tasteless, except when it is
combined with oxygen, when it tastes
sour. The general characteristics of impurities
in sulpher in acid to get [illegible]
of impurities in sulpher, it is first
to be washed in distilled water, or snow
water, as either of them are equally
pure. then distill it, or pour on it its
own weight of oxymuriatic acid, then
wash it again until the water will 
not effect the vegetable blue. as any 
of the vegetable blues are a delicate test
for acid (Infusion of blue cabage or
the scraping of radishes) sulpher is
frequently found in [crises], in radishes
and many other vegetable substances


applied to a lamp, and as soon as the
temperature is sufficiently increased the
phosphorated hydrogen gas is evolved 
A portion of the process, [illegible] of the water combined with
the potash, whereby a portion of the hydrogen
was disengaged, which united with 
the phosphorus, and passed over in form 
phosphorated hydrogen gas. This is what 
is vulgarly called. Jack with a lantern, or 
will o the wisp.
Of Sulpher. Sulpher is always found in 
abundance in the neighborhood of volcanoes.
It is easily fused; & easily volatilized when 
heated to 176 fev. it evaporates, at 180 it begins
to melt, & at 220 it is converted into vapour 


James Blythe D.D. 13th Jany 1824
Put together equal quantities of sal
ammoniac and common quicklime,
pulverised seperably, into 
a retort and apply it to a 
lamb and ammoniacal gas
will be evolved. You
must in  making this gas, allow
some considerable time for the atmospheric
air to escape, for if you do 
not, you will not succeed in obtaining
this gas is a pure state
Phosphorated hydrogen gas, is one of the most
inflamable substances in nature.
It is made of consentrated potash, & 
phosphorous Put into a [illegible] and 


labour complicated with convulsions
is also a a cause of rupture of the 
uterus. In irritability of the system
during parturition of an unusual kind,
bleeding, opium, enemata and cahartics
should be employed. There are
three modes of treating rupture of 
the ruptured uterus, viz:
1 Leave the case to nature.
2 Deliver per vias naturalis. and 
3. The caesarean operation; if their
are reasons to believe that the child 
is alive


[sympons] do not occur.
Causes of rupture of the uterus
are 1st. External violence, as
from blows, etc. 2d. from improper
efforts to turn the child in 
mal presentations after the waters
are discharged. Where violence
has been [illegible] to the uterus during 
utero gestation, though not of
sufficient severity to interrupt that
important process, it rearly fails
to produce bad effects at the period
of parturition Never attempt to 
turn the child while the uterus is
acting, but always wait untill it
is quite [illegible] turning is attempted


uterus when this kind of inflamation 
does not take place, the woman 
does not feel very much inconvenience
[illegible] about the ninth month,
at which time she feels pains
similar to those of an expulsive kind,
after which she sometimes carries the
child for several years. The [ovation]
opens generally after the rupture takes 
place & a sanguineous discharge
takes place, after the foetus has passed
in the abdomen, which has induced
a belief that a miscarriage has
taken place The uterus gradualy
regain its unimpregnated size, if the
patient sustains the accident & 
inflamation, & all others alarming 


W H Richardson. M.D. 12 Jan. 1824.
On Rupture of the Gravid Uterus.
On the occurance of a rupture of the
gravid uterus, nausea, vomiting,
& frequently attend every to syncope
with pain & a contiousness of an
accident of a serous kind has
taken place by the female
Haemorrhages sometimes take place,
the child is fitt to struggle for 
a considerable time in the cavity
of the abdomen, after this 
accident, which subsides [however]
after a while. Peritoneal inflamation 
is most generally the consequence
of a rubture of the 


with cathartics, antimonials, etc. and 
in cases of great danger, a part of the
aqueous humor of the eye by a [illegible]
or couching needle. The humour will
collect again in a short time. Ophthalmia
appears frequently in form of
the bilious fever which must be
treated as you would that disease.
Bleeding from the temporal arteries
have been premised with great effects 
in violent forms of ophthalmia, where
it has been carried to sufficient
extent. The common colyrea, is nothing
more than palliatives in this disease
[illegible] from colyrea
sulph zinc zfs.


glands take place, their are swellings of
the eye lids, with an inflamation of the
eyes of a troublesome kinds.
(Carry with you a magnifying glass
for the purpose of examining the eye etc.)
The depleting system must be vigorously
persisted in, in inflamations
of the eye of a purulent ophthalmia
The lancet must be used 
to a very considerable extent, as
partial bleeding, only will not prevent
disorganization of the eye! 
No plan is as good, as powerful
bleeding, even to ad deliquium [illegible], 
which is to be repeated on the
slightest recurance of inflamation, 


generally in about two or three weeks.
In scrofulus, there is often a chronic
inflamation of the eye, arising from acute
inflamation which is very difficult
to remove. Cold by operating on the 
general system, is often a cause of inflamation
of the eye One of the most
dreadful forms of inflamation of the eye
is that which results from a sudden
repulsion of gonorrhoea, or metastatous 
from the urethra to the eyes This occurs
but seldom. It is this disease while the
eye remains inflamed the discharge
from the urethra ceases. In scrofulus
constitutions, often for a year or
two before the scrofulus swelling of the 


of the pupil, or contraction, the child
retrieved its sense to the last moments 
of its existence.
Of Ophthalmia.
(Textures of the eye)
Membranes
Cartilages
Ducts
Humours
Glands
Hairs
In this disease the conjunctiva 
is the texture most commonly 
effected. Swelling of the 
eye lids, which discharge a purulent
nature, with redness, sensibility to lift,
head ach, febrile symptoms sometimes
run high this is called Egyptian 
ophthalmia. By an energetic course
of treatment, strictly antiphlogistic, the
symptoms, begin to yield about the
third day, and by a combination of
this treatment the inflamation subsides 


Brown M.D. January 13th 1824.
Many of the symptoms which are attributed
to hydrocephalus, and inflamation of the brain 
are frequently referable to the state of the 
digestive organs. In cases of inflamation
of the brain the application of
cold, applied by water in a stream 
from the spout of a tea kettle, or otherwise,
as cold is in such cases one of the 
most powerful antiphlogistic remedies that 
can be employed It is a vulgar error
than a dilated pupil is an unequivocal
sign of inflamation, or hydrocephalus of
the brain Dr. Brown related a case
where three quarts of water was discharged
from the cranium without any dilatation 




when nourishment is withheld from 
without, to supply the blood to absorbants
are taken up the fat or cellular substance to contribute to it, and is
again taken up from the very place
it was taken. In [illegible] the
absorbants are fuller than when it is not
[illegible] when from long and protracted [illegible]
the absorbants contain a fluid colourd like
blood which [showing] that there is a violent
action of the absorbents
Blythe, D.D. Caloric is the cause of fluidity, and
antagonizes attraction of cohesion Elasticity combined
Dr B [illegible] [illegible] [illegible] wherever a body changes its state, it 
combines [illegible] at caloric, or seperates from 
caloric


food then trickles down until it comes
in contact in succession with all the
different portions of the intestines, when 
according to difference of structure, a 
different effect is producd on the
food where the nutriment is recd into the
large intestines it is returned then something
in the cells of the color, it is then the 
incrementition point, and is part off in 
the form of [illegible] The bowels, lungs, skin 
and kidneys [diminute] from the chyle different
substances which [illegible] it for the
use of the system.
1 Mastication, & terminals in the [illegible]
capillaries of the system. The lymphatic 
system or the absorbents which have [illegible]
affix the buttons up at the [illegible]


Dr. Drake On the phenomena of nutrition 14th Nov. 1823.
The first object of mastication is the mechanical
division of the article of food, 3d. to mix it with 
mucous of saliva, 2d to increase its temperature
the quanty of mucous & saliva that is swallowed
with our food is as 12 is to 6 The masticated
bubuss [illegible] mucous from the fauces, and
oesophagus is their passage through these into the
stomach After the food arrives into the stomach
a [illegible] peristatic, or [illegible] motion takes
place in the stomach, which forces the food into
the lower orrifice of the stomach, the chyle which 
is the result of gastric digestion is taken up 
when this remains in the lower orifice of the
stomach food undigested, where the [chym]
is formed for it is found no where else, the 


[illegible] bodies, compounded & undiscompounded
supporters of combustion, the substance which is essentially
necessary to be present when that phenomena is [illegible]
on, oxygen, clorine & iodyne are [undecompound]
able supporters of combustion the compoundable
support of combustion is the atmospheric air, etc.
Affinities in a direct ratio to the attraction of cohesion
& vice versa cohesive attraction is an antagonist
to affinity Sulphurous acid pourd, on pulverised 
[illegible] of time, an action takes place, and 
carbonic acid gas is evolved & the [cartonal] is
converted into a sulphate of lime while by 
pouring sulph acid on a piece of carb:e of lime not
pulverisd the action is very fitt, which is in [consequence]
of the cohesive attraction


Dr. Blythe Nov. 14th 1823
Comminution, this phraze is made use of to explain the
reduction of hard heavy bodies into to small particle by which it is made
to swim on water Consentration, is made us of in respect 
to fluids, & is the solidifying of fluids Saturation, a
fluid may be saturated with salt, or sugar, often which it
will dissolve a third, and even a fourth substance
The reason why, is, because water has a greater [illegible]
for one substance than an action. Temperature, it is a 
term made use of to express the present [portion] of [calorie]
Hydro-oxyde, is a phraze chiefly applied to mettals
& in every instance where it is used, water is implied
Hyper-oxydisation when any substance has combined
with it the highest possible portion of oxygen.
All substances which do chemically combine, do
it by definite particles; not by fractions all [powderable]
bodies are divisable not by [continued] division we come to a particle that
is indivisible


By sympathy is ment a consent of parts, or
in other words, its that medium through which 
an impression made on one organ of
the system is conveyed to another, and another
[illegible] the whole or a great part of
the system feels that impression.
Dr Brown rheumatism an inflamation of the fibrous membrane never 
suppurated very [seldom] Whenever there is a difference 
in structure, there is difference in function, and disease
hence they require difference in treatment.
Pruseate of potash, and sulphat of iron were
thrown with the body at different parts united
in the [illegible] duct, and lungs, and formed [prusean]
blue The blood threw up a coagulum of a strong
blue colour & the lymph and chyle deposited the prussic
blue which than [illegible] [illegible] [illegible] alive
the fluid in the [illegible] duct was blue


thirds way, to wit, water
Ponderable bodies, all matter is ponderable
Dr. Caldwell
1. Irritability,
2 Sensibility
3 Sympathy
Explanation of these
By irritability is men a susceptibility
to impression, or a capability of being acted on by 
stimuli. By sensability is ment a capability of
refering to the thing impressing, or producing an
effect upon one or more of the organs of the system,
and is [illegible] a mental & 
corporeal phemonina, for instance I smell a 
roe, which, makes an impression on my 
olfactory senses, & by the operation of my 
mental powers I refere that impression, to the rose


Flint is silver in as pure a state as we can find it 
Lititious events, it discribes a variety of 
natural bodies
Calcarious earth, it is used to discribe
chalk, marble, or old bodies when [lime] is 
combined with carbonic acid
Radicals. this term is used to designate
the elements of bodies, or the component
parts of bodies, more properly speaking 
simple radical & compd radical 
example sulph: acid, is composd of a simple
radical its base a simple substance, veget
acids, the base of these acid are compound
[bodies], carbone & hydrogen or something [illegible].
Specific gravity such is the
method of ascertaining the [weight] of one 
body by another by comparing it with a 


fibrine, consits of carbone, hydrogen, [illegible] & oxygen
[Glutin] is composed of 4 parts, carbon hydr: [illegible] & osygen
gelatin Do 47 carbone 7 hydro, [azoti] 16 oxygen [27]
[illegible] of [gum] ca 42 ox 52 [illegible] 4 carbon 43 oxygen 49 hydrogen 6
Sugar of milk & vegetables the cane carbone 40 oxygen 50 & hydr 6
Albumen carbon 52 oxygen 23 hyd: 7 [illegible] 15
animal & vegt. oil. hydrogen & oxygen
Dr [Blyston] Novr 13th 1823
ous ite ie ate
salts formd by some base & suplhurous acid is namd sulphates
Those salts formd by some base & sulphuric acid is namd [sulphat??]
Salts. when an acid is combined with an earth, or alkali
forms salts. (Levoisure says there 134 different
species of salts) Earth, by this term is ment [metalic] oxydes, on incombustable
bodies. There are 9 earths, [illegible] [illegible]
strontius [glucin], [sytriat], barietes], [illegible], [illegible]
& magnesia.


hydrogen & nitrogen (from ammonia
sugar, gum [illegible] ol contains less carbone than
fibrone, albumen, cheese & gelatin & more [oxygen]
the vegetable acid contain, contain more 
carbone & less oxygen the the former, ol. oil
contains hydrogen & carbone in a great
proportion and very little oxygen
gum arabic, rice, & sugar, sustain the
system for a considerable portion of the 
years ([carbone], oxygen & hydrogen)
ammonia & uric acid seems to be
the product of animal action
[illegible], a juice which exudes from 
muscles sometimes,


Dr Drake Nov. 13th 1823
Vegetable gellies, are somewhat analogous to the
gelatin of animals, ([illegible] (natural), implies the whole range
of natural scenery) empyreumatic acetic acid & 
oily substances, vegt: mucilage is composed of
and contains [azote] it furnishes by 
[distilation] ammonia, glutin is formed in vegetable
substances approach the fibrin of animals
Albumen is a proximate element of nutritious
vegetables, as the cabage etc. it coagulates by heat, putrefies
and affords [azote], extractive matter is another
proximate element of nutritious vegetables etc.
Sugar is another proximate element of vegetables
and has a very wide range vegetable oils,
expressed, or fixd is another [illegible] of [illegible]
carbone & hydrogen they are principle components


Nitrogen forms a portion of the atmospheric
air of hydrogen it is a term used to [illegible] the
base of inflamable air. It is never exhibited in 
its separate state, like oxygen it is always in a 
state of combination
Of Carbne. It is a simple substance, or at least
it is supposed to be so. The diamond is a pure 
[illegible] of carbone, charcole is the base of [illegible] is impure carbone. 
It is the base of carbonic acid gas.
Intimately connected to carbons are the carbonates,
which is a term used to designate
certain [salts], which are formd by carbonic
acid there are 4 earthy carbonats
the carbonate which are formed by 
[illegible]
magnesia


vitality etc. etc. in all of the various
membranes, textures etc. of the body which is 
essentially necessary to health.
Dr Blythe. Nov. 13th 1823.
An oxyde is any substance combind with oxygen
in a portion not sufficient to render it acid.
Rust of iron. Is the protoxyde of iron, which is 
capable of being converted back into its metalic
state ( I would say that instead of its being [protoxyde];
that it was the carbonate of iron ([illegible])
Protoxyde of iron, & dutoxydes of iron. The former
has less, the latter more oxygen.
Of Nitrogen, is thought by sir H Davey
to be composed of oxygen & hydrogen, and is
not a simple substance, as is said by 
the old chemists. It has been called [azote], but
Dr. Blythe objects to the use of that term to nitrogen 


In hydrophobia, the great & only pathognomonic 
symptom of which is an inability to swallow
in consequence of a loss of the use of the
muscles of deglutition, in consequence of
an affection of the nerves originating in 
the cervical spine. This operation of a 
purgative is passing through the alimentary
canal will produce dissimilar pains
in consequence of its action or [dissimilar]
structures (By close observations you may 
tell where yr: medicine is operating, by a difference
of pain) Disease consists in a 
loss of balance of circulation, excitability
and sensation etc. a resporation of which 
must be affected to restore heatlh.
There is a particular point of circulation



gas etc. etc.
Dr Brown. Novr 12th 1823
An attention to first principles, says Dr Rush, is the
only way to make a good physician. Similar causes
operating on similar subjects, under similar circumstances,
always produced similar effects This is thought 
to be the great fundamental principle in relation
to the practice of medicine by Dr Brown a [illegible]
of the structures of the human body modifies the
disease to which it is subject Disease of the 
[south] are billiary or abdominal; those of the
north, are thoracic organization distinguishes 
vegetables from inanimate substances, such as [illegible]
etc. The brain is the center of life cranial 
brain, the [illegible] brain, and the ganglioniotion
in Dr Browns division of 


Latent calorie. By latent calorie we mean
that calorie which is insenable, which is illustrated
by a piece of light bread diped in water
in which [then] will by water of two kind, 1st
that which is chemically combind with the flour
to make the bread. 2d that which is in the
[illegible] of the bread & may be squeesed out, leaving
the bread as it was. It is necessary to form a part
of the body itself.
Of Gas. by which is ment a permanently elastic
[illegible] form fluid existing at every degree of temperature. 
Intimately connected to this, is the word vapour
which is distinguished from gas by its being susceptable [illegible]
to water, by taking away a portion of its
calorie of basis, or the base of gas, by these
terms is ment the substance which is converted
into gas, as oxygen is the base of oxygen 


bodies. Caustic soda, & muriatic acid united
together forms the muriate of soda, or common 
table salt, which is an example of chemical 
affinity, or composition by the union of
zinc & copper is formed a substance called brass etc.
Of repulsion. It is that principle directly opposed
to attraction, & is a universal principle
repulsion takes place between two bodies equally 
electrified, & between two [illegible]
Of calorie. It is the matter of heat, or the
[illegible] itself, which is the cause, and heat the
effect Than are 2. or three
Free calorie, by which is ment calorie in 
an uncombined state, or if attacked
to other bodies not chemically combined,
or those calorie which can be tested by the thermometer




Brown Price.
Richardson Edwards
Caldwell Baker.
Blythe Gillespie, or Price.
Dudley [Morse].
Drake Sullivan, or Price.
The memosi sensitiva or sensative [plant]
We the undersigned bind & oblige ourselves by 
honour & with a due sense of the improvement to be
derived from a quizing club, do associate ourselves
for said purpose, & the hour of meeting will be 
at a time most convenient to all, we shall
meet 3 times a week Monday Wednesday
and Friday nights


W w W


A 
A D