A MANUAL OF DISEASES OF THE NOSE, THROAT, AND EAR r - BY '•>- E. B. GLEASON, M.D., LL.D. Professor of Otology in the Medico-Chirurgical College; Aurist to the Medico- Chirurgical Hospital; Surgeon-in-Charge of the Nose, Throat, and Ear Department of the Northern Dispensary; Formerly one of the Laryngologists to the Philadelphia Hospital Illust rat ed THIRD ENTON* JMOEWG^Y, REVJSED PHILADELPHIA AND LONDON W. B. SAUNDERS COMPANY 19 14 Copyright, 1907, by W. B. Saunders Company. Reprinted November, 1907, and July, 1908. Revised, entirely reset, printed, and recopyrighted August, 1910. Reprinted July, 1912. Revised, entirely reset, printed, and recopyrighted October, 1914 Copyright, 1914, By W. B. SAUNDERS COMPANY PRINTED IN AMERICA PRESS OF W. B. SAUNDERS COMPANY PHILADELPHIA TO JHon. Menrp f. Walton, President of the Medico-Chirurgical College and Hospital, Philadelphia A LEARNED, GENIAL GENTLEMAN AND A GOOD FRIEND IN AFFECTIONATE APPRECIATION OF HIS MANY ACTS OF KINDNESS AND WORDS OF WISE COUNSEL THIS LITTLE BOOK IS INSCRIBED BY THE AUTHOR PREFACE TO THE THIRD EDITION The second edition has been carefully revised and all that seemed obsolete, or likely to become so, eliminated to make room for the numerous additions necessary to bring the book up to date without increasing its size. A book on one of the specialties in medicine designed for the use of students and general practitioners cannot be too concise, provided that the subject is efficiently covered and descriptions lose nothing in clearness by brevity. As in the previous editions of this little book, an effort has been made to eliminate all surplus words. More space has been given to diagnosis and treatment than to rare and difficult operations that the beginner should not do. However these operations are described with sufficient minuteness for the student to practice them upon the cadaver. This method of study cannot be too highly indorsed because it produces a practical knowledge of the anatomy and topog- raphy of the respiratory tract and ear and skill in the handling of instruments that cannot otherwise be readily obtained. It is true that the trend of opinion has lately been toward con- servative intranasal operations on the accessory sinuses rather than radical external operations, for example, like that of Killian, but such operations while rarely required upon the living are excellent practice for students upon the cadaver. The same is true of operations upon the internal ear. Considerable attention has been given to directions for the preparation and preservation of anatomical specimens and sec- tions through the nose and ear. The preparation of such speci- mens helps to fix the anatomy and relationship of the parts in the mind of the beginner, and hence specimens prepared by the student himself are more valuable for future reference and study than similar preparations purchased in the shops. In the commoner operations like tonsillectomy and sub- mucous resection of the nasal septum, when the methods of 11 12 PREFACE TO THE THIRD EDITION operating are almost as numerous as the operators, a technique is given which, in the experience of the author, is simplest, quickest, easiest, most free from unnecessary traumatism and risk, and yields the largest proportion of good results. The author has never had a death from tonsillectomy nor a case of severe sepsis; yet he feels that other methods of operating may be equally as good as that described. However, the beginner should acquire as soon as possible the technique best suited to him for the commoner operations and not abandon it without good reason; because operators who have no estab- lished techniqne but are constantly shifting from one method to another, usually have the largest number of fatalities and unsatisfactory results. The chapter on tonsils and adenoids although entirely rewritten for the second edition has again been carefully revised. Comparatively much space has been given to the consideration of diseases of the nasal accessory sinuses. While radical operations designed to obliterate these cavities have been advocated when indicated, the fact is clearly stated that the majority of acute inflammations recover as the result of comparatively simple treatment, and that in the chronic suppurations no operation should be done that will leave the patients in a worse condition than before. The chapter on diseases of the internal ear has been rewritten and considerable new material added to bring this part of the book completely up to date. The same is true of the intracranial complications of aural suppuration. The formulae at the end of the book have been carefully revised and only those retained which have not been super- seded by better remedies. The various methods of employing cocain, adrenalin, etc., have received careful attention and considerable new material added to this section of the book. E, B. Gleason. 2033 Chestnut Street, Philadelphia, Pa., October, 1914. PREFACE This manual was written to supply students and general practitioners with the essential facts of Rhinology, Laryn- gology, and Otology in as concise a form as possible. The more important facts of the anatomy, physiology, and pathology of the upper respiratory tract and ear have received careful consideration, so that the volume might prove sufficiently complete for study or reference by undergraduates during their college years and for practitioners taking a post-graduate course in laryn- gology and otology. The details of inspection, examination, and diagnosis of the nose, throat, and ear conditions and the use of the commoner instruments of diagnosis and for the making of applications have received very careful and compara- tively lengthy detailed description. The same may be said of minor operations. Methods of treatment have been simplified as much as possible, so that in most in- stances only those methods, drugs, and operations have been advised which, by the actual experience of the author, have proved essential to the accomplishment of the desired result. At the end of the book is a collec- tion of Formulas designed to represent more than a mere catalogue of prescriptions. Hence a detailed description of the better methods of use of each of the more im- portant drugs has been interpolated, which it is hoped the reader will find useful and suggestive. 13 14 PREFACE The history of the gradual development of some of the more important instruments, methods of treatment, and, more especially, operations has been considered of sufficient practical importance to be briefly outlined. In some instances the prognosis in cases not operated on has been accentuated by quotations from the writ- ings of standard authors of the period before such operations were practised. The book contains 262 engravings, a considerable proportion being original or drawn from dissections made by the author. The value of carefully made sections through the upper respiratory tract and ear for purposes of study and reference is stated and a method of preparing and preserving such specimens described. E. B. GLEASON. CONTENTS PAGE The Laryngoscope 17 The Art of Laryngoscopy 21 Laryngeal Image 26 Rhinoscopy 3° Otoscopy 36 Accessory Instruments 40 Sterilization of Instruments 50 Examination of Patients 53 The Nose 56 Anatomy of the Nose 56 Physiology and Pathology of Mucous Membranes .... 62 Inflammation of Mucous Membranes 65 Diseases of the Nose 66 Diseases of the Nasal Septum 125 Diseases of the Accessory Sinuses 150 The Pharynx 193 Anatomy of the Pharynx 193 Diseases of the Nasopharynx or Postnasal Space 199 Diseases of the Oropharynx 206 Neuroses of the Pharynx 243 Diseases of the Uvula 246 The Larynx 250 Anatomy of the Larynx 250 Diseases of the Larynx 260 15 16 CONTENTS PAGE The Ear 3X4 Anatomy of the Ear • 3X4 The External Ear 3*4 The Middle Ear 3^ The Internal Ear or Labyrinth 325 Tests for Hearing 33° Pathologic Conditions of Nose and Pharynx Causing Disease of Ear 339 Diseases of External Ear 35° Diseases of the External Auditory Canal 362 Diseases of the Middle Ear 379 The Membrana Tympani 379 Diseases of the Tympanum 392 Systemic Diseases Causing Otic Inflammation . . . .437 Operations Upon the Middle Ear 442 Intracranial Complications of Otic Disease . . • • 49° Diseases of the Perceptive Apparatus 515 Formulas 533 Index . . . . 567 DISEASES OF THE NOSE, THROAT, AND EAR THE LARYNGOSCOPE The laryngoscope is a combination of two mirrors arranged to enable the observer to see the interior of the larynx. The larger and concave mirror, called the reflector, is attached to the observer's head by a head-band, and the smaller and plane mirror, called the laryngeal mirror, is introduced into the back part of the mouth in such a manner as to be directly above the glottis; so that light reflected from the reflector upon the laryn- geal mirror illuminates the interior of the larynx, and enables the observer to see its image in the small mirror. In 1854 Signor Manuel Garcia, by means of a dentist's mirror and a hand-glass, studied the movements of his own vocal cords during phonation, and accurately described the registers of the voice in a paper read before the Royal Society of London in 1855, and hence the honor of inventing the laryngoscope is usually accorded to Garcia. The laryngeal mirror consists of an oval or round piece of silvered glass, mounted in a metal frame and attached to a wire stem at an angle of not less than 120 degrees. Such mirrors vary in size from | inch to i| inches in diameter, and are numbered 1, 2, 3, 4, 5 by instrument-makers. However, smaller mirrors, Nos. 00 and o, and larger mirrors, Nos. 6, 7, and 8, may be obtained, and are occasionally useful (Fig. 1). The reflector is a concave mirror 3I inches in diameter, of about 12-inch focus, and made of silvered glass, mounted in a 17 18 DISEASES OF THE NOSE, THROAT, AND EAR metal frame, so arranged that it is capable of attachment by a universal joint either to a head-band or the source of illumination. The instrument known as Fox's head-band (Fig. 2) consists of steel or, preferably, brass strips hinged together so that they can be folded about the mirror to protect it and form a conveniently shaped package to be carried in a pocket. When in use the head-band assumes the position of a line passing over the head from the forehead to the occiput. It is held firmly in position by the hinged bands, which when unfolded act as a spring. It has the advantage that at once it adjusts itself to heads of varying shapes and sizes, and hence is convenient in class-demonstration to pass from student to student. However, a head- band of leather is decidedly the preferable instru- ment, because it is lighter. The leather should be black to prevent discoloration by sweat. The Fig. i.- Laryngeal mirror in u n i ver sal handle, j Fig. 2.-Reflector with Fox's head-band. joint by which the mirror is attached to the forehead is by no means a matter of indifference, a double ball-and-socket joint greatly facilitates.the adjustment of the reflected light, and renders it possible to bring the perforation in the center THE LARYNGOSCOPE 19 of the reflector closer to the eye, a decided advantage in ex- amining narrow cavities like the nasal passages or the auditory meatus. Some years ago the author had made for use in his class-room the head-band shown in Fig. 3. At that time his principal object was cheapness. The instrument, how- ever, proved so light, comfortable, and efficient that it has become his favorite head-band. Proper Method of Wearing the Reflector.-The reflector should be worn upon the forehead over the left eye, and the light should be reflected from it upon the face of the patient, so as to form a circle bounded above by the tip of the nose and below by the front of the chin. When worn over the left eye, Fig. 3.-Gleason's head-band. with the source of illumination to the left of the patient, it is possible to secure a better illumination of the nose and mouth with less frequent manipulation of the reflector. If, however, the source of illumination be at the patient's right, the reflector is more conveniently worn over the right eye. Sources of light used in otoscopy are natural and artificial. Daylight, preferably that reflected from a white cloud, arti- ficial light, furnished by a Welsbach mantle, Argand burner, oil lamp, or the electric light, are now generally used. What- ever the source of the illumination, the light is directed into the auditory canal, mouth, or nose by means of the reflector. The apparatus shown in Fig. 4 may be used either over an 20 DISEASES OF THE NOSE, THROAT, AND EAR ordinary student's lamp, Argand burner, Welsbach light, or the electric light can be placed within the apparatus. The Welsbach light gives by far the most satisfactory illumina- tion, but because of the frequent moving of the bracket the mantle, which should be used without a glass chimney, has a much shorter life than if the light were stationary. How- ever, in spite of this disadvantage, the Welsbach light is prob- ably the best for office work and the Argand burner for the dispensary or elsewhere when the lamp is liable to rough handling. The electric light, after it has passed through the Fig. 4.-Adjustable gas bracket with light concentrator. lens and been reflected by the mirror, yields a bright image of the filament with deep intervening and surrounding shadows. The source of light should be at the patient's right somewhat behind him, and on a level with the top of his ear. As the heights of patients vary greatly when seated, it is well to have some means by which the position of the light can be quickly and conveniently changed. There are several forms of ad- justable gas brackets manufactured that answer fairly well. One that can readily be manipulated with the left hand while the operator remains seated will be found to be the most con- venient. That shown in Fig. 4 has large conic bearings which do not wear loose so rapidly and leak as some of the other patterns. THE LARYNGOSCOPE 21 THE ART OF LARYNGOSCOPY Laryngology is the seeing and describing what is present in the larynx. The word signifies a treatise on the larynx and its diseases. Laryngoscopy is simply the art of viewing the interior of the larynx. The optical law involved in laryngoscopy is that the angle of reflection is equal to the angle of incidence. This law is illus- trated by the fact that the laryngeal mirror must be placed Fig. 5.-Diagram illustrating the principle of the laryngoscope (Lennox Browne) in the patient's pharynx, above and behind the larynx, and at such an angle that light received on its surface is reflected downward into the larynx. The rays then forming the laryn- geal image will return along the same path, and be reflected at the same angle into the eye of the observer. From this it follows that the nearer the center of the head-mirror is placed to the eye of the observer, the better will the image of the larynx be seen (Fig. 5). We should bear in mind that the laryngeal image is a re- flected one, and that, therefore, it is reversed anteropos- teriorly, owing to the fact that the laryngeal mirror is above and behind the opening of the larynx (Fig. 6). 22 DISEASES OE THE NOSE, THROAT, AND EAR The observer should sit opposite to the patient so that his eye is on a level with, and about a foot from, the mouth of the patient, whose head should be slightly raised and inclined backward. The knees of the observer should be either at the left or on either side of the patient's knees. For office use it is most convenient to have piano stools, or chairs, the seats of which can be raised or lowered, so that the difference in the heights of different patients can be com- pensated for, and the eye of the observer can be brought on a level with that of the patient. If a head-reflector be used it is advisable for the observer first to place his head in an easy position and then move the reflector until the disk of reflected light falls in the opened mouth of the patient with its center at the base of the uvula, thus illuminating all the surrounding parts. This method of procedure has the very practical advantage that if the observer has to turn his head to see to pick up an instrument or for any other purpose, bringing his head back into the former easy position at once reilluminates the patient's pharynx without readjusting the reflector. Introduction of Laryngeal Mirror.-The laryngeal mirror is first warmed by holding its reflecting surface over a flame for a short time to prevent moisture condensing upon it. The handle should be held between the thumb and forefinger of the right hand like a pen-holder, with the reflecting surface of the mirror downward. The forearm should be flexed upon the arm and the hand slightly backward upon the wrist and held a little below the mouth of the patient. By a forward motion of the hand and a slight raising of the arm and unbending of the elbow the mirror should be quickly carried into the mouth, following the curve of the hard palate until the back of the mirror touches and raises the uvula, pressing it upward and backward as far as possible. Meanwhile the left hand of Fig. 6.-Diagram of laryngeal mirror, illustrating the re- version of the re- flected image (Len- nox Browne). THE LARYNGOSCOPE 23 the observer has grasped the patient's protruding tongue, hold- ing it well forward by means of a towel or napkin to prevent slipping through the fingers. Controlling the Tongue.-The protruded tongue of the patient should be grasped between the outstretched thumb and index-finger of the left hand, protected by a napkin or towel to prevent slipping, in such a manner that the forefinger, being placed against the lower teeth, projects above their edge, and thus forms a roller upon which the tongue can move without its frenum coming in contact with the sharp edge of the lower incisors. The thumb being placed on the upper surface of the tongue and the middle finger above the chin of the patient, a slight rotatory motion of the observer's left hand will then not only control the motion of the tongue of the patient but also keep all involuntary movements of his head in check. When the operator has to use both hands in operating or making applications, the patient should be taught this maneuver and requested to hold his tongue forward himself. The mirror should not touch the tongue or palate; and, when in position, it should be held steadily and not allowed to tremble, or gagging and retching will result. Should the slightest sign of this occur, the mirror must be quickly with- drawn, and only reintroduced when the patient has had time to recover his breath and confidence; or the gagging will be repeated on an attempt to reintroduce the mirror, and the throat finally become so sensitive that a further examination will be impossible at that sitting. To bring the laryngeal image into view the handle of the mirror is brought to one side until it lays in the angle of the patient's mouth, and the hand holding it is steadied by one or two fingers resting on the cheek of the patient. This procedure brings the hand out of the line of vision. The mirror is next slowly but steadily turned until the image of the larynx appears upon its surface. The patient should now be requested to say "Ah" in order to raise the epiglottis (Fig. 7). Obstacles to laryngoscopy are: 1. Irritability of the pharynx, 24 DISEASES OF THE NOSE, THROAT, AND EAR produced by trembling of the hand holding the mirror, causing gagging and retching. 2. Want of proper adjustment of the light, without which the larynx cannot be illuminated, even when the mirror is in the proper position. 3. Undue irrita- bility or peculiar formation of certain parts of the throat. 4. Raising of the back of the tongue upon the approach of the Fig. 7.-Method of making a laryngoscopic examination (Cohen) mirror, in spite of the traction made upon its tip. 5. Too large or pendent epiglottis. Gagging and retching can be prevented generally by avoiding to touch the tongue and palate while introducing the mirror, and by holding it steadily in its proper position when introduced. Irritability of the pharynx may be relieved THE LARYNGOSCOPE 25 by letting the patient swallow a glass of ice-water before in- troducing the mirror; or, if that should fail, the use of a spray of cocain solution from an atomizer will generally produce the desired effect. If the back part of the tongue rises so as to obstruct the view in spite of traction on its tip, it may be caused to lie flat in the mouth by steady pressure with a tongue-depressor (Fig. 8). When the epiglottis is so large or pendent as to obstruct the view, the glottis sometimes can be seen by causing the patient to laugh or sing in a high pitch. Autolaryngoscopy.-The ob- server who wishes to study his own larynx should seat himself with his back toward a window through which the direct light of the sun enters. In front of him should be a plane mirror, so placed as to reflect a ray of sunlight into his open mouth. All being in readiness, he seizes his tongue with a napkin held in his left hand, and pulls it forward. His right hand now carries a laryngeal mirror to the back of the mouth, its progress being watched in the mirror before him. When properly placed, the sunlight from the plane mirror is reflected by the laryngeal mirror into the larynx, and its image appears upon the laryngeal mirror and is reflected forward upon the plane mirror, where it may be studied by the observer. Arti- ficial light may also be used for autolaryngoscopy by having the source of illumination at one side of, on a level with, and slightly behind the observer's head; while a concave reflector is Fig. 8.-Bosworth's tongue-depres- sor. This is one of the most con- venient of numerous forms of tongue- depressors, some of which carry min- iature electric lights. 26 DISEASES OE THE NOSE, THROAT, AND EAR placed at one side of the plane mirror to reflect the light upon the laryngeal mirror in the back part of the mouth. Infraglottic Laryngoscopy.-In some cases in which trache- otomy has been performed and the cannula is fenestrated, a small mirror may be so introduced into the cannula as to obtain a view of the under surface of the vocal cords, which are red instead of white. Unfortunately, the mirror must be so small that little else can usually be seen. LARYNGEAL IMAGE Normal Image.-At the upper part of the mirror (Figs. 9-11) is seen the reddish-yellow arch of the epiglottis (l) with its cushion (c). In front of the epiglottis and extending downward across the mirror are seen two pairs of bands-'the Fig. 9.-The larynx in gentle breathing (Lennox Browne) Fig. io.-a, The larynx in tone-production; &, the larynx in deep breathing (Lennox Browne). outer red, and the inner of a pearly white. The former are tbe ventricular bands (p), while the latter are the vocal cords (v). In deep breathing a triangular opening is seen between the vocal cords, through which we can see into the inferior cavity of the larynx and view the anterior part of the cricoid cartilage as well as some of the tracheal rings below it (w, p). THE LARYNGOSCOPE 27 In some cases two dark circles can be seen in the depth of the trachea, indicating the openings of the bronchi (b). During tone-production the opening between the vocal cords is narrowed to a slit, and this space is called the rima glottidis or glottis (chink of the glottis). At the termination of the vocal cords are the arytenoid cartilages, with the interarytenoid space or commissure between them. From each side of this commissure, a fold, called the aryepiglottic fold, extends forward to join the arch of the epiglottis. Upon each of these folds are two nodules-the cartilages of Wrisberg (w) and those of Santorini (s). These latter surmount the arytenoid cartilages Fig. ir.-Modified Kahler tracheo-bronchoscope. The handle of the instrument can be rotated downward into a vertical position. Attaching the epiglottis to the tongue is seen in the mirror a light-colored band-'the glosso-epiglottic fold. On each side are two grooves, called the glosso-epiglottic fossae. The color of the mucous membrane, as seen in the laryngeal image, varies from the pearly whiteness of the vocal cords to the reddish yellow of the epiglottis and the pinkish red seen in other locali- ties. There is also considerable variations of color, within the limits of health, in different individuals, and even in the same individual under different conditions. As seen by artificial light it is always redder in color than by direct sunlight. Direct Laryngoscopy.-Kirstein long ago demonstrated that it was possible to get a direct view of the interior of the larynx by strong pressure on the base of the tongue, with a long 28 DISEASES OF THE NOSE, THROAT, AND EAR curved tongue-depressor. His method never became popular. Killian modified the depressor into a tube with a beaked end designed to enter the vestibule of the larynx and lift the epi- glottis out of view. In this manner it is possible to see the interior of the larynx with the right hand free for the intra- laryngeal use of instruments. The laryngeal surface of the epiglottis, aryepiglottic folds and arytenoids are painted several times with 20 per cent, cocain to which an equal amount of 1-1000 adrenalin has been added. The patient is requested to cough and expectorate any excess of solution and if necessary the interior of the larynx is cocainized finally in the same manner. A Kahler bronchoscopic handle is fitted to a grooved spatula (Fig. 11) Fig. 12. - Killian's apparatus for suspension laryngoscopy. which under direct illumination is passed over the epiglottis which is pushed forcibly against the base of the tongue to bring the interior of the larynx into view. During this procedure, the patient is seated on a low stool with his head extended forward and upward; the operator standing in front. By this method it is possible to remove foreign bodies, tumors, etc., with straight instruments by direct vision. THE LARYNGOSCOPE 29 Direct laryngoscopy has been further improved by placing the patient on his back upon an operating table and support- ing his head by means of a Killian suspension laryngoscope which is clamped to the table (Fig. 12). Suspension laryn- goscopy has the advantage that the operator has both hands free for the manipula- tion of instruments and has a wide field of vision with the larynx at close range so that more extensive intra- laryngeal operations are possible than by the indirect method which, however, has the advantage that it is often possible to remove foreign bodies and small growths with less inconven- ience to the patient than the mere intro- duction of the instru- ments necessary for direct laryngoscopy. Direct tracheoscopy and bronchoscopy was first performed by Killian for removing foreign bodies. It is essentially the same as direct laryngoscopy except that the spatula is replaced by a tube, of a dimension corresponding to the patient's age. If done under local anesthesia, the trachea is cocainized as well as the larynx, after which the tube is passed between the cords into the trachea or bronchus. The mortality from the removal of foreign bodies in the lower Fig. 13.-Types of instruments for autoscopic operations. 30 DISEASES OF THE NOSE, THROAT, AND EAR air passages has been reduced by this method to practically zero. The method is also of advantage for the diagnosis of obscure lesions of the lower respiratory tract. The advantages of direct laryngoscopy over the indirect are few. In cases where this epiglottis is low omega shaped, it is of decided advantage and also in cases where it is im- possible to obtain with a mirror a good view of a tumor at the anterior commissure. However, those who are skillful in the indirect method generally find the direct method much more distressing to the patient. RHINOSCOPY Rhinoscopy is the art of inspecting the nasal cavities, and may be divided into anterior and posterior rhinoscopy. Anterior rhinoscopy is the inspection of the anterior nares through the nostrils, and posterior rhinoscopy is the inspection of the vault of the pharynx and of the posterior nares from behind. The word nares should be applied solely to the anterior and posterior openings of the nasal cavities. The posterior open- ings are sometimes called the choanae. The postnasal space or nasopharynx is the cavity bounded in front by the posterior nares or choanae, above by the vault of the pharynx, behind by the pharyngeal wall, and below by the soft palate. Technic of Rhinoscopy.-The simplest method of inspection is to raise the tip of the nose with a finger, and draw the ala away from the septum by means of a bent probe. If now the patient's head is tilted somewhat backward, so that a strong light from a window or other source of illumination can enter the dilated nostril, the nasal cavity will be illuminated for a considerable distance, and the condition of its lining mucous membrane may be inspected. This was the method commonly employed previous to the invention of the forehead reflector. The opening of the nostril may, however, be effected more RHINOSCOPY 31 conveniently by means of a nasal speculum, of which there are a great variety. Of these one of the most popular is Killian's (Fig. 14). The instrument shown in Fig. 17, in most noses cannot be displaced by facial contortions of the patient. He has to use his hand in order to remove it from his nose. It is sometimes necessary, however, to snip away the vibrissae Fig. 14.-Killian's nasal speculum. Fig. 15.-O'Reilly's modification of the Killian speculum. before an operation in order to obtain a better view of the interior of the nose. This occupies but a moment and is a matter of little consequence. Two sizes of the instrument should be at hand, and the spring of the instrument should be adjusted by bending until it does not cause sufficient pressure to occasion the patient pain or annoyance. The instrument is introduced by directing its blades along the floor of the nose until they have nearly disappeared within the nasal chamber, when the instrument is turned upward until it grasps and separates the rim of the nostril as an eye speculum separates the eye lids. Allen's 32 DISEASES OF THE NOSE, THROAT, AND EAR speculum Fig. 16, a later instrument acts on the same principal except that it widens the rim of the nostril vertically, instead of horizontally. When using a nasal speculum the instrument and patient's head should be moved in such a way that the different parts of Fig. 16.-Allen's nasal speculum. the interior of the nose are successively brought into view. Any secretions that obstruct the view should be removed by the atomizer or forceps, or wiped away with cotton wrapped on the end of an applicator; and any change in the bulk of the parts should be tested with the probe to determine its density. If an anterior hypertrophy obstructs the view of deeper Fig. 17.-Gleason's nasal speculum. structures, cocain solution should be applied to reduce its size and allow light to penetrate into the deeper parts of the interior of the nose. The first structure brought into view by anterior rhinoscopy is the vestibule, in which are a number of coarse hairs called vibrissae, while a fold of skin or mucous membrane lies between the vestibule and the inferior meatus. To the inner side is the septum and to the outer side the inferior turbinated bone, form- RHINOSCOPY 33 ing the roof of the inferior meatus. Above the inferior tur- binate is the middle meatus, roofed in above, except for the olfactory slit, by the middle turbinated body. Through the olfactory slit in some individuals a portion of the superior turbinate can be seen. Posterior rhinoscopy is, to all intents and purposes, the same process as laryngoscopy, except that a smaller mirror Lowerjaw. Fig. 18.-Course of light rays in posterior rhinoscopy. Sagittal section of head (Sahli). must generally be used, the reflecting face of which is turned upward instead of downward. The tongue, also, instead of being drawn forward with a napkin, is held down by a tongue- depressor. The relative position of patient and observer is 34 DISEASES OF THE NOSE, THROAT, AND EAR the same as in laryngoscopy, except that the patient's head is not bent backward, but is either held perpendicularly or is inclined slightly forward. The rhinoscopic mirror, having been warmed, should be introduced into the pharyngeal cavity behind the velum palati, and so placed as to reflect the light upward and forward into the vault of the pharynx and into the posterior nares (Fig. 18). For this purpose mirror No. i, o, or oo is generally most useful, but a larger mirror can sometimes be used to advantage, and should always be em- ployed when the space between the palate and the pharynx is sufficient to permit it. Posterior rhinoscopy is much more difficult than laryngoscopy; but, except in the case of young children, patience and dexterity will almost always enable the observer to obtain a glimpse of the various parts of the posterior nares and vault of the pharynx without the use of accessory instruments. When disease of these structures exists, the examination is usually easy because of their inter- ference with the motion of the palate and the relatively wider space between the palate and posterior pharyngeal wall. Obstacles to Posterior Rhinoscopy.-In many cases the palate will rise forcibly as soon as the mirror has been introduced, thus completely shutting off the view of the parts above. This difficulty can often be overcome by requesting the patient to breathe through his nose, or emit a nasal sound like that of the French letter n, or say "One." Some operators ask their patients th snore or to "smell," that is, to draw the breath in- ward forcibly through the nose, as if endeavoring to perceive an odor. The observer should in all cases avoid touching the back of the tongue or pharyngeal wall, as otherwise gagging and retch- ing immediately occur, and further examination is rendered futile. Occasionally a palate retractor will be convenient. The wire hook of the instrument is passed behind the soft palate, and by pulling the stem gently outward the uvula and palate are pulled into the desired position and held forward by the RHINOSCOPY 35 pressure of wire loops, which are slid along the stem until they rest within the nose. Posterior Rhinoscopic Image.-Except in cases of cleft palate, it is impossible to obtain a complete posterior rhino- scopic image, such as is shown in Fig. 19, but by varying the position of the mirror the different parts may be brought into view and studied one after the other. Usually the first object seen is a triangular plate, with its apex downward-'the posterior margin of the nasal septum. Above it is a mass of glandular tissue-'the pharyngeal tonsil-while at each side Fig. 19.-Normal picture in posterior rhinoscopy. Diagrammatic, in that to obtain a complete picture, the position of mirror must be repeatedly changed: S.n, Septum; Ch., choana; P.m., soft palate; U., uvula; C.i., inferior turbinate body; C.m., middle turbinate body; C.S., superior turbinate body; occasionally visible. Beneath each turbinated is the corresponding fossa. O.R., roof of 'pharynx; T. opening of Eustachian tube; W., promontory of tube; R., Rosenmuller's, fossa (After Schnitzler.) lower down are the crater-like orifices of the Eustachian tube. In front of these, and projecting toward the septum, are the posterior aspects of the turbinated bones. The middle turbinated bone is usually first brought into view and rarely the dim outline of the superior turbinated bone may be dis- tinguished above and in front of it. Below the middle tur- binated bone the upper part of the inferior turbinated bone is readily perceived; but to see the lower part of this structure and the floor of the nose requires considerable practice in the use of the rhinoscopic mirror. A somewhat better view of Rosenmuller's fossae, the Eustachian tubes and the lateral and 36 DISEASES OF THE NOSE, THROAT, AND EAR posterior walls of the nose can be obtained with the naso- pharyngoscope, Fig. 20, than with the mirror. In about 40 per cent, of cases the ostea of the sphenoid sinuses are visible and frequently the ostea of ethmoid cells. Fig. 20.-Holmes nasopharyngoscope. OTOSCOPY Otoscopy is the art oE inspecting the visible parts of the ear. Ordinarily these parts are the auricle, the external auditory meatus, and the outer surface of the membrana tympani. Deeper portions of the ear are, however, visible when the overlying structures are destroyed by disease or are removed during an operation. Generally the dim outlines of the malleo-incudal joint can be seen through a normal or atro- phied drum-head, and occasionally the chorda tympani nerve and other structures. Otoscopic Reflector.-The reflector generally used to illu- minate the auditory canal and its fundus is the same as that employed in laryngoscopy and rhinoscopy (Fig. 2). The specula used in otoscopy are funnel-shaped instruments constructed of hard rubber or metal. Different forms are sold under the names of Wild's, Gruber's, Toynbee's, Boucheron's (Fig. • 21), Kramer's, and Politzer's specula. Gruber's specula are probably the best for ordinary purposes of otoscopy because a transverse section of their caliber at right angles to their long axes more nearly corresponds with a similar section of the external auditory meatus. However, Boucheron's specula (Fig. 21) are better adapted for use during an operation upon the middle ear, and with many otologists are favorite specula for purposes of inspection and treatment, because their wide OTOSCOPY 37 proximal rims afford greater space for the manipulation of instruments, and a firmer grasp to the thumb and fingers when the instrument is held within the auditory canal. Ear specula are usually sold in "nests" of three or four sizes fitting into a case. Those constructed of hard rubber are easily broken, and those manufactured of German silver and nickel plated are necessarily thicker than is desirable; a thin, solid silver speculum, aside from its expensiveness, being the preferable instrument. Relative Positions of Patient and Ob- server in Otoscopy.-The patient and observer may both stand in front of a window or the source of artificial light, or both may be seated upon chairs or piano stools so adjusted that the eye of the observer and the ear of the patient are in the same horizontal plane. The ear to be examined should be toward the observer, and the patient's face turned somewhat away from him, because the auditory canal generally extends in a direction inward, forward and somewhat downward. If the reflector is worn upon the forehead, the source of light should be above or to one side of the patient's head, and so placed as to throw the auricle into the shadow. To introduce the speculum the observer should first direct the light from the reflector upon the orifice of the meatus, and then straighten the auditory canal by gently drawing the auricle upward, backward, and slightly outward, at the same time endeavoring to see the drum-head without the use of a speculum. In many instances this can be accomplished satis- factorily, and the observer should not be in haste to introduce the speculum, as it may dislodge and push into the field of view a flake of wax or epithelium, which will greatly interfere with a distinct view of the membrana tympani. The auditory canal having been straightened in the manner described and the Fig. 21.-Bouciieron's specula. 38 DISEASES OF THE NOSE, THROAT, AND EAR parts being fully illuminated, the speculum is held by its rim with the thumb and finger and gently introduced with a slight rotary motion into the auditory canal, so that its long axis exactly corresponds with that of the canal. The greatest care should be exercised in introducing the speculum not to use it as a lever in such a manner as to bring its sharp edge in contact with the wall of the canal and cause pain; obstruction to the progress of the speculum being overcome by moving Fig. 22.-Otoscopy with the reflector and ear speculum. The arrows represent course of light. the whole instrument in a direction opposite to that in which the obstruction is felt until the membrana is brought into view, when the speculum may, if necessary, be retained in position by grasping it and the auricle in the manner shown in Fig. 22. Obstacles to Otoscopy.-'The chief obstacle to the beginner is caused by so misdirecting the long axis of the ear speculum that it does not correspond with the long axis of the auditory canal, so that a portion of the auditory canal is brought into view or only a portion of the membrana is seen. Under such OTOSCOPY 39 circumstances the end of the speculum within the ear should be moved about until a satisfactory view of the drum-head has been obtained. Generally it will be found that the cause of failure has been that the axis of the speculum has been directed too far backward and upward. Another cause of difficulty is excessive sensibility of the auditory canal or swelling of its walls, the result of diffuse inflammation. Sometimes a satisfactory view of its deeper parts can be obtained under such circumstances by gentle and persistent effort, a small speculum being used to dilate the auditory canal. Siegle's pneumatic speculum (Fig. 23) is an air-tight chamber to which specula of various sizes can be attached by Fig. 23.-Siegle's pneumatic specula. means of a screw-joint. The side of the air-tight chamber carries a perforated knob, over which is slipped a rubber tube terminating in a rubber bulb. The proximal end of the instrument is glazed either with plane glass or with a convex lens set at an angle of 45 degrees with the long axis of the instrument. When the instrument is in position within the auditory canal, the surgeon is enabled to judge of the mobility of the whole or of a part of the menbrana tympani by observing its movements during condensation and rarefaction of the air in the auditory canal brought about by the action of the surgeon's hand upon the rubber bulb. Before using the instrument it is well to slip a short piece of wet rubber tubing 40 DISEASES OF THE NOSE, THROAT, AND EAR over the end of the speculum to ensure its fitting into the auditory canal as nearly air tight as possible. When the Eustachian tube is impervious to air the pneumatic speculum furnishes the only means of determining the mobility of a part or the whole of the mem- brana tympani. Instead of using a rubber bulb to produce rarefaction and condensation of the air in the auditory canal, a piston-syringe may be em- ployed or the masseur of Delstanche. It should be borne in mind that it is entirely possible to rupture some membrana tympani by too vigorous use of aural massage. Machines whose motive power is compressed air, electricity, or a water motor are sometimes employed. They yield more rapid rarefaction and condensation of the air of the auditory canal than the hand bulb and occasionally may prove more useful. ACCESSORY INSTRUMENTS The laryngeal sound consists of a piece of silver wire, rounded at one end and inserted in a universal handle (Fig. i). It should be sufficiently long to reach the anterior angle of the glottis without bringing the fingers holding the handle into the patient's mouth, and thus obstructing the view, and sufficiently firm to resist a considerable amount of pressure without bending. The cotton applicator consists of a piece of aluminum or, better, copper or iron wire of about the same size and length as the laryngeal probe, with roughened ends; so that a piece of absorbent cotton can be tightly wrapped around one end with- out fear of its becoming loose. This tuft of absorbent cotton will carry enough solution for any application within the Fig. 24.-Allen's nasal applicator. OTOSCOPY 41 laryngeal or postnasal cavities. For applications to the nasal cavities smaller instruments are desirable, and Aden's applicator (Fig. 24) is better adapted for this purpose. Allen's probe (Fig. 25) consists of a conic piece of soft, malleable steel wire fitted into an aluminum handle. It is extremely light and delicate and may be used either for the nose or for the ear. When used as a probe, a few fibers of absorbent cotton are wrapped about its tip in order to cover its sharp extremity. Fig. 25.-Allen's probe. The tip of the instrument can be bent into the form of a hook to bring forward nasal polypi or ascertain their place of origin, the thickness of their pedicle, etc., or to probe the attic of the tympanum. The presence of exposed bone is readily detected by the spicules catching in the cotton fibers and imparting a characteristic resistance. It may be used also for the applica- tion of chromic acid and other caustics. The Atomizer.-In most forms of throat and nasal disease, sprays are extremely useful, not only to cleanse the parts and remove accumulated secretions, but also to spread medicated solutions over a large surface. For use in the laryngologist's office and as an atomizer to fit into the rhinologic instrument bag for use in treating patients at their homes, the atomizer (Fig. 26) is convenient, as it throws a fine spray either upward, downward, or straight forward. However, for the patient's use at home other types of atomizers are preferable and the physician should specify by prescription the atomizer that will yield the coarse or fine spray required for the judicious treat- ment of each case; also he should select for his patient an atomizer that is not readily broken and easily kept in order; or he will have the mortification of discovering that home treatment has been the merest pretence because of the in- efficiency of the atomizer. As a general rule, atomizers for patient's use should have a bottle made from thick, strong glass 42 DISEASES OF THE NOSE, THROAT, AND EAR so shaped that it cannot readily be laid on its side. To prevent clogging of long fine tubes, the nozzle should be as short as possible, readily cleansed, and made of metal rather than brittle, hard rubber. The hand bulb should be large and made of good quality rubber. The air-current necessary to produce the spray from atomi- zers may be supplied either by a rubber hand bulb or an air- compressing apparatus. Fig. 26.-DeVilbiss atomizer. In spraying the nose, pharynx, or larynx with a hand atomizer, the bottle of the instrument should be grasped be- tween the thumb and first finger of the right hand with the rubber bulb in the hollow of the hand. The rubber bulb can then be pressed by the three remaining fingers with sufficient force and rapidity to give a continuous spray. This method of employing the atomizer leaves the left hand free to elevate the tip of the nose or manipulate a tongue-depressor. In spraying the nasal cavities the tip of the nose should be ele- vated with the finger and thumb of the left hand, and the end of the atomizer should rest against either the thumb or finger of the operator, and not the rim of the patient's nose. The OTOSCOPY 43 use of this method will prevent the necessity of sterilizing the end of the atomizer tubes each time they are used upon a patient. Because secretions tend to gravitate toward the floor of the nose, especial attention should be directed toward the inferior meatus in washing out the interior of the nose. The head of the patient is tipped slightly backward and the spray from the atomizer directed somewhat downward, that is, in a direction toward the lobe of the ear. Under such circumstances the nasal secretions that have accumulated on the floor of the nose are readily washed into the pharynx and are hawked down and expectorated. The stream of the atomizer can then be di- rected to any portion of the upper part of the nose which, on inspection, appears covered by secretions. Fig. 27.-Soft-rubber eye, ear, and ulcer syringe. However, masses of mucus are more readily removed from the pharynx by means of solid streams of fluid than by the coarsest spray from an atomizer. For this purpose a piston syringe holding about two ounces is generally employed. The patient opens his mouth and bends forward over a bowl. The conical nozzle of the syringe is introduced into one nostril and the fluid injected into the nasopharynx, around the sep- tum and out of the other nostril. For the patient's use at home a syringe, made of one piece of soft rubber (Fig. 27), answers a useful purpose for syringing the nose or ear. The nozzle of the syringe is made of soft rubber, and hence can be inserted in the auditory canal or nose with little danger or pain. When an atomizer or syringe is prescribed for a patient's use 44 DISEASES OF THE NOSE, THROAT, AND EAR at home, the object that the surgeon wishes to accomplish should be carefully explained to the patient and he should be instructed in the use of the instrument and how to keep it in good order. If this is not done, the patient's use of the Fig. 28.-Syringes with interchangeable nozzles: a. Syringe of J-dram capac- ity for cleansing and applying solutions to the attic by means of Blake's cannulas (2, 3, and 4). Also for making applications to the Eustachian tube by means of nozzle 7 and an ordinary Eustachian catheter. When fitted with the bayonet tip 6 and a hypodermic needle it may be used for the production of local anesthesia of the ear or tonsil by injections of solutions of cocain and adrenalin, b. Syringe, holding 21 drams, to be used with Blake's cannula for cleansing middle ear or with postnasal nozzle (1) for cleansing the posterior nares. It is convenient where the operator prefers a piston- to a bulb-syringe. C. Dentists' tooth syringe, capacity 1 ounce. This is probably the best syringe for removing impacted cerumen and for coarse syringing of the auditory canal. When fitted with a moderately large long silver nozzle (4) any of the accessory cavities of the nose that can be probed can be washed out through their anatomic orifices. For this purpose the silver nozzle should be made of pure silver, so that it can be bent readily to the requisite curve, and the operator should be provided with four or five such nozzles about 5 inches long and of the diameter of Nos. 3, 5, 6, and 8 of the French catheter scale. Instead of these sil- ver nozzles a Eustachian catheter may be employed, or nozzle 5, fitting on to nozzle 7, which screws on to the syringe when nozzle 8 is unscrewed. It is well for the opera- tor to be provided not only with several sizes of the straight cannula (4), but also with several sizes of Blake's cannulas (2 and 3), to be used with syringe b or c. atomizer, for example, at home will amount to practically nothing. If an atomizer and a detergent spray, such as Dobell's solution, is prescribed with the main object of cleans- ing the nose, the patient should throw his head back and point OTOSCOPY 45 the beak of the atomizer downward (not upward), so that the main force of the spray will be directed along the floor of the nose into the nasopharynx. It should be demonstrated to the patient so that he thoroughly understands that if while he is using the atomizer he breathes gently through his nose the spray will pass downward behind the relaxed palate into his mouth and can be expectorated. That, on the contrary, if he holds his breath, the fluid will be retained in the naso- pharynx upon the contracted palate and will run out of his nose as soon as his head is lowered, with the result that the nasopharynx is not as efficiently cleaned as would otherwise be the case. AIR INLET AIR OUTLET ■WATER ' REGULATOR WATER INLET WATER OUTLET Fig. 29.-The Little Wonder pump. The interior of the nasal cavities can be cleansed as thoroughly by means of a hand atomizer as by an atomizer whose spray results from the use of the most expensive of air-compressing apparatus; but the latter are convenient, and where a large number of patients are to be treated save the surgeon's hand the fatigue that would result from long-continued use of the hand atomizer. There are a large variety of air compressors for sale in the instrument stores, and it is difficult to state which one is the most practical and useful. However, a satisfactory apparatus for furnishing compressed air is a water air-pump, such as is used by saloon-keepers for 46 DISEASES OF THE NOSE, THROAT, AND EAR forcing beer and ale from the barrels in the cellar into the faucets in the bar-room. The water-pump is attached to a water-pipe in such a manner that water may run through it and flow into the waste-pipe or sewer. It is automatic and continues in operation until the air-pressure in the receiver equals that of the water in the supply pipe. Some pumps furnish an air-pressure double that of the water in the supply pipes, but are proportionately slow in their action. As an air receiver, when one of these pumps is used, an orna- mented copper cylinder may be placed in the surgeon's office; but nothing answers the purpose better than an ordinary galvan- ized wrought-iron cylinder or "boiler," such as is found in most American kitchens as a reservoir for hot water as a part of the so-called "circulating boiler" apparatus for supplying hot water for domestic purposes. The water air-pump may be attached to the water-pipes under- neath the sink in the physician's office, and the air receiver placed down cellar, or both pump and air receiver may be placed in the cellar should the plumbing permit of such an arrangement. Whatever the position of the air receiver, a pipe or tube should lead from it to a stop-cock upon the wall, immediately at the side of or beneath the adjustable gas bracket. Attached to the stop-cock there should be a rubber tube three or four feet in length, terminating in an automatic cut-off (Fig. 30). When compressed air is used for other purposes than supply- ing an air-current for atomizers, the pipe from the air re- ceiver should terminate in a bracket of stop-cocks from which rubber tubes lead to the nebulizer, the aural masseur, etc. The automatic cut-off is an instrument by which compressed air is conveniently supplied to an atomizer. The end of the Fig. 30.-Boekel's automatic cut-off. OTOSCOPY 47 instrument (a) is attached to the rubber tubing of the com- pressed-air apparatus, and the nozzle (b) of the instrument inserted into the hole in the nipple of the atomizer, from which the hand bulb previously has been removed, and by pressing down the lever (c) a current of compressed air is forced through the atomizer in the same manner as if a rubber hand bulb were used. The current of air ceases as soon as the lever is released. In using the automatic cut-off, the atomizer is held in the right hand and the lever of the automatic cut-off pressed down- ward by the thumb. Sinks.-A most convenient adjunct to a laryngologist's office is a sink. It should be supplied with hot and cold water. There have been a number of sinks manufactured for the use of physicians and hospitals. The best are constructed of white porcelain, and the flow from the spigot is controlled by foot levers. This arrangement prevents the necessity of turning off the water with the hands after they are washed. A swinging spittoon may be attached to the sink or wall in such a manner that it can be swung out of sight when not in use. A water spittoon such as is employed by dentists is not more convenient, but certainly looks better than even the most ornamental receptacle for expectorations, and although bulky adds somewhat to the appearance of care and neatness about the office. Pynchon's cabinet (Fig. 31), for instruments, linen, etc., is a convenient office accessory. It is provided with 18 drawers of different sizes (each partitioned to accommodate regular and special instruments) and compartments for clean and soiled linen. The nebulizer is useful because vapors will penetrate where fluids and the spray from an atomizer will not. These instruments, therefore, may be employed in the treatment of diseases of the middle ear and the accessory cavities of the nose and the smaller bronchial tubes. Nebulizers are manufactured in many styles, from the single nebulizer, for patients' use at home, to more elaborate instru- 48 DISEASES OF THE NOSE, THROAT, AND EAR ments for office use, which consists of a number of nebulizers connected together in such a manner that one or more can be utilized at a time. Inhalers are employed for the inhalation of the vapors of a drug suspended in hot water. The simplest form of this in- strument is the bottle-inhaler. It consists of a wide-mouthed bottle, through the cork of which two glass tubes are thrust Fig. 31.-Pynchon's cabinet. One reaches nearly to the bottom of the bottle; the other passes simply through the cork, and is bent at the upper extremity. The bottle is filled one-third full of a solution, and the patient, by inhaling through the bent glass tube, causes air to bubble through the fluid and become impregnated with the volatile substances in the fluid before being drawn into the lungs. Compound tincture of benzoin (i teaspoonful to the inhaling bottle one-third full of hot water) is a domestic remedy of considerable reputation and some value in inflammation of the upper respiratory tract. OTOSCOPY 49 The Powder-blower.-Remedies are often applied to the interior of the nose and larynx in the form of an impalpable powder. For this purpose the instruments shown in Fig. 3 2 and 33 will be found useful. The reservoir insufflators of David- son and similar instruments are very convenient and obviate the necessity of loading the powder-blower each time that it is used. However, they have the disadvantage of sometimes be- Fig. 32.-Davidson's reservoir powder-blower. The instrument is also made with a curved tip. coming temporarily clogged, and at the next attempt to use them discharge a much larger quantity of powder than is required. A very large amount of powder might be un- expectedly thrown into a patient's larynx from this instrument, causing momentarily great distress and severe laryngeal spasm, which, however, quickly subsides if the patient is given a glass of water to drink and told to hold his breath for a moment. Fig. 33.-Powder-blower. Such accidents can, however, be avoided by not using a reser- voir powder-blower for laryngeal work. The Hot-air Apparatus.-Hot air is occasionally beneficial in the treatment of diseases of the upper respiratory tract and middle ear. It allays the swelling and irritation and decreases blood-pressure. It is useful in acute inflammatory diseases of the accessory sinuses and middle ear, although the relief is often 50 DISEASES OF THE NOSE, THROAT, AND EAR transient. An effective method of application of an apparatus used by dentists for drying tooth cavities or more elaborate apparatus, in which air is heated by an electric current, are occasionally useful, as they permit a continuous current of hot air tobe thrown on inflamed tissue in any portion of the mouth, nose, or auditory canal. Sometimes it affords at least tem- porary relief from the pain and tinnitus of acute middle-ear catarrh. STERILIZATION OF INSTRUMENTS All instruments used in operations upon the nose, throat, or ear should be carefully sterilized by boiling in a 5 per cent, bicarbonate of sodium solution. After an operation the instru- ments are placed in a tray and soaked for five minutes in cold water to dissolve the dried blood adhering to them. They are then scrubbed with hot water and soap. If they need polish- ing, sapolio or a fine sand-soap should be used. They are then boiled for five minutes in a 5 per cent, solution of sodium bi- carbonate and rapidly dried while still hot in order to prevent rusting. For the rapid drying of larger instruments, wiping with a sterile towel while the instruments are still hot answers every purpose. For smaller instruments and those with delicate joints-'Cannula, snares, etc.--it is better after boiling to wipe them with a towel and then immerse them in 95 per cent, al- cohol for a minute or two. They should then be carefully wiped with a towel, so that every particle of moisture is removed by the wiping and the evaporation of the alcohol. Instruments for examination and treatment, such as tongue- depressors, specula, probes, applicators, etc., used so fre- quently during the office hours or in dispensary work that, un- less the surgeon possesses a large stock of these articles that can be boiled at the beginning of the hour in sufficient numbers to furnish each patient a special instrument without exhausting the supply, are best sterilized by burning with wood alco- STERILIZATION OF INSTRUMENTS 51 hoi. This method has the advantage that it takes but a moment and can be done in the presence of the patient, who is thus assured beyond peradventure that only sterile instruments have been used in the diagnosis and treatment of his case. The operator should be provided with two white enameled steel trays. In the first of these should be placed instruments for the examination and treatment of a patient. Over the instruments should be distributed a teaspoonful or two of wood alcohol, which is then lighted with a match. The flame lasts Fig. 34.-Sterilizing instruments by flaming with alcohol. but for a moment, but the instruments are heated far above the temperature of boiling water and are, of course; rendered absolutely sterile. Small instruments treated in this manner cool almost as rapidly as they are heated. Larger instruments, like tongue- depressors, retain their heat for an inconvenient time, and it may be necessary to cool them by dipping them in water, spraying them with an atomizer containing an alkaline wash, or pouring a little grain alcohol over them. As the instru- ments are used they are placed in the second tray, and are sterilized in the same manner before being again employed. The disadvantages of the method are that it cannot be used for small aluminum instruments or those soldered with soft solder and that it soon tarnishes the instruments. Syringes, soft-rubber tubes, hard-rubber nozzles, and glass instruments are best sterilized by soaking them for five or ten 52 DISEASES OF THE NOSE, THROAT, AND EAR minutes in a 5 per cent, aqueous solution of formalin (40- volume aqueous solution of formaldehyd gas). The barrel of the syringe should be filled with the solution and the entire syringe immersed. If the syringe is sterilized in this manner immediately before being required it should be carefully rinsed in sterile water before being used to prevent the irritating effects of formalin, for it should be borne in mind that even very dilute solutions of formaldehyd gas are very irritating to the mucous membranes of the nose, throat, or middle ear. Atomizers should be used in the manner previously described, so that the tips never come into actual contact with the patient on whom they are used. When made with interchangeable tips the extra tips may, of course, be kept in an antiseptic solution, that of formaldehyd being perhaps the most reliable. Although boiling in sodium bicarbonate solution and the other methods of disinfection described above are reliable, it is advisable for psychologic reasons at least to have a special set of instruments for syphilitics and another special set for those with tuberculosis. Preparation of Operator.-Before operating on the nose or throat the surgeon should prepare himself, as for any other op- eration, by scrubbing his hands and arms with green soap, rinsing in alcohol, and immersing his hands in bichlorid solu- tion, or prepare himself by any other method he has found satisfactory. Sterilization of Nose.-Unfortunately we do not possess a reliable antiseptic for sterilizing the nose or nasopharynx. Any solution of carbolic acid (probably the most sedative to mucous membranes of the common antiseptics) strong enough to kill bacteria would excite a local inflammation that would interfere greatly with the rapid healing of the operative wound. The same remark applies in still greater degree to other anti- septics. However, before an operation the mucous membrane should be freed, especially in atrophic cases, from adherent mucus by thorough syringing with an alkaline or normal salt solution. EXAMINATION OF PATIENTS 53 EXAMINATION OF PATIENTS First listen passively to the patient's story of his illness; asking judicious but not leading questions, so as to elicit the facts of the case, such as the influence of his employment upon his health, or any inherited tendency that he may have toward disease of the nose, throat, or ears, cause of the disease, the length of time that it has continued, and the symptoms other than disease of the nose, throat, or ears that may be present. In questioning the patient the physician should bear in mind the effects of "suggestions" upon patients of nervous tempera- ment as regards tinnitus. Many neurotics with disease of the middle ear will experience for the first time subjective noises in their ears upon being asked leading questions in regard to tinnitus, and afterward complain of the presence of this symptom, which previous to that time had not attracted their attention. Careful notes of the patient's history should be made in the case-book, and especial prominence be given to the symptoms of the disease from which he seeks relief. Examine the tongue, as to whether coated or clean, pale or flabby, or of a natural color and resistance; look for ulcerations or mucous patches upon the tongue or the inside of the mouth; and also notice the shape and condition of the teeth. Having depressed the tongue, observe the palate and uvula, the ante- rior pillars and tonsils, the posterior pillars and posterior pharyngeal wall. Notice any change from the natural color, shape, or mobility of the parts, the presence or absence of foreign bodies or hardened secretions. The nose should next be examined by anterior and posterior rhinoscopy and, finally, the laryngeal mirror should be intro- duced. In these examinations notice the condition of the parts in the following order, viz: (i) Color and condition of the mucous membrane; (2) size and shape of the part examined; (3) loss of substance by ulcers, etc.; (4) presence of foreign bodies, neoplasms, or accumulated secretions; (5) mobility of 54 DISEASES OE THE NOSE; THROAT, AND EAR the parts and functional disturbances. During the examina- tion touch any suspicious swelling with the probe, so as to ascertain its mobility, and whether it is composed of bone, cartilage, or softer structures. Wipe away secretions and trace a flow of pus to its source in an ethmoid cell or one of the sinuses. As the examination progresses, the result should be jotted down in the case-book, and any deviation from the nor- mal in size or shape, or the presence of neoplasms or foreign bodies, sketched upon the margin of the page. In cases complaining of aural disease the hearing should next carefully be tested by the voice, the watch, and the tuning- fork. In making a record of the results of the tests for hearing it is convenient, to facilitate easy reference at a subsequent period, to devote one or more lines in the note-book to each ear, using abbreviations to economize space; for example, as follows: a. p. Dextra)S H.V. = whisper, 3 ft. W. = T.-F. C2, vertex best in A.S.M. =gg. M.A. = Jg. or (Hear- (Voice). (Watch). (Tuning-fork). (Mastoid). (Meatus R. E. ing). Auditorius). (Right Ear). A. S. (Auditus H_ v. = L. C. 6 ft. W.=y. T.-F. c2, M.=Jg. M. A. gg. or (Hearing). (Voice). (Loud Con- (Watch). (Tuning- (Mastoid). (Meatus L. E. versation). fork). Auditorius). (Left Ear). In the above record of the tests of the hearing power it will be noticed that bone-conduction, as tested by a C2 fork, is somewhat impaired for the right ear and apparently increased for the left, indicating that there exists in the right ear not only disease of the conducting apparatus, but also impairment of the receptive apparatus. For most cases one tuning-fork, pref- erably a large C2 fork, is all that is required; but the aurist should be provided with at least five forks-C, C, c2, C3, C4-• which should all be used in testing the hearing in certain cases. After the hearing has been tested, the aurist should inspect the parts of the ears made visible by means of otoscopy, care- fully noting the condition of the external auditory canal and EXAMINATION OF PATIENTS 55 drum-head; and if the membrane be wholly or partly destroyed as the result of disease or accident, noting the condition of the mucous membrane of the tympanum and other structures that may be visible. In most instances it is advisable to make a diagram or rude drawing of the condition of the tympanum, and in making notes as to the result of otoscopy to give to each ear one or more separate lines in the note-book in the same manner as when recording the results of the tests for hearing. The patency of the Eustachian tubes should next be tested by means of the Politzer method and the aural stethoscope or, if necessary, the Eustachian catheter should be used. In suitable cases the patient's equilibrium should now be examined and the functional reaction of the labyrinths to turning, caloric and galvanic tests. THE NOSE ANATOMY OF THE NOSE The external nose is an arch-shaped framework, bony above and cartilaginous below, covered by integument ex- ternally and lined within by mucous membrane. It is separated into two portions, practically two noses, by the nasal septum. The bony arch or bridge of the nose (Fig. 36) is composed of the nasal processes of the superior maxillary and the nasal bones. Fig. 35. Fig. 36. Figs. 35 and 36.-Bones and cartilages of the external nose. Fig. 35, Side view; a, Cartilage of septum; b, upper and (c) lower lateral cartilages; d, sesamoid carti- lages; e, cellular tissue; f, nasal bone; g, nasal process of superior maxillary bone. Fig. 36, View from below: a, Lower lateral cartilage; b, sesamoid cartilages; c, cellular tissue. The cartilaginous arch consists of the upper and lower lateral cartilages and the sesamoid cartilage, usually three on each side of the nose. The cartilages are bound together by strong con- nective tissue, and by the action of muscles upon them the opening into the nose can be dilated or narrowed. The aloe or wings of the nose contain no cartilage, but con- sist of a mass of cellular issue and fat. 56 ANATOMY OF THE NOSE 57 The nasal septum consists of bone and cartilage covered by mucous membrane. Its cartilaginous portion is the so-called triangular cartilage, because it fits into a triangular space be- tween the perpendicular plate of the ethmoid and the. vomer (Fig. 37). However, the cartilage of the septum is quadri- lateral in shape. The perpendicular plate of the ethmoid and the vomer, the nasal crests of the superior maxillary, palate, Pig. 37.-Osseous and cartilaginous septum of the nose: 1, Triangular cartilage of the septum; 2, median plate of the lower lateral cartilage, sometimes called columnar cartilage and cartilage of the aperture; 3, cartilage of Jacobson; 4, sup- ravomerine cartilage sometimes present; 5, vomer; 6, perpendicular plate of ethmoid; 7, ethmovomerine suture; 8, sphenoidal sinus; 9, nasal bone; 10, palate bone (Arnold). and nasal bones, and the nasal spines of the frontal, enter into the formation of the septum. It is developed from a bilobed mass, the mesial nasal process; and when its lower portion ossifies to form the vomer this bilateral character is preserved to the extent that a deep groove is formed along the upper bor- der of the vomer between the plates. In this groove there is a strip of cartilage which frequently persists during the entire adult life and is called the vomerine or supravomerine cartilage. 58 DISEASES OF THE NOSE, THROAT, AND EAR The groove, sometimes distorted into an imperfect tube or into other shapes, is called the vomerine crest. Ridges of bone and cartilage extending obliquely upward along this crest are the result of the distortion or over-growth of the vomerine crest or cartilage. The nasal septum is covered by mucous mem- brane, beneath which, near the nasal floor, is ill-developed erec- tile tissue. Specialized nerve-filaments of the sense of smell occupy a small area in the mucous membrane of the upper portion. The skin covering the external nose, especially at the tip, is rich in sebaceous glands, when diseased the contents form comedones. At the tip of the nose beneath the skin is a cushion of fat which when hypertrophied aids in the produc- tion of "pug nose." The skin extends into the nose nearly to the anterior extremities of the inferior turbinated bones, and at the entrance into the nares it is usually covered with short thick hairs, the vibrissae. The muscles of the external nose are the levator alae nasi, depressor alae nasi, levator alae nasi props, and the musculis apicis. These muscles by their action dilate and make narrow the anterior nares during respiration. The arteries of the external nose are the lateralis nasi, a branch of the facial, nasal branches of the ophthalmic and in- fra-orbital, and the septal artery from the superior coronary artery. The nerves of the external nose are branches from the facial, infra-orbital, infratrochlear, and- the nasal branch of the ophthalmic. The nasal cavities are the commencement of the upper respiratory tract. They extend from the anterior nares to the posterior wall of the pharynx, and consist of two chambers, divided from each other by the septum. The floor is separated from the roof of the mouth by comparatively thin structures and hence is parallel to it. The roof is formed by the nasal bones and nasal spines of the frontal bone, the horizontal plate of the ethmoid, and the anterior wall of the sphenoidal cells. ANATOMY OF THE NOSE 59 The lateral walls are formed by portions of the frontal, lacrimal, ethmoid, sphenoid, and superior maxillary bones. Upon the lateral walls of the nasal chambers are the superior, middle, and inferior turbinated bones (Fig. 38). The inferior turbinated is a separate bone, but the superior and middle turbin- ated are portions of the ethmoid: At birth this portion of the ethmoid is often divided into three or even four turbinated bones by grooves that disappear later in life. The agger nasi is a slight elevation at the junction of the anterior end of the middle turbinate with the superior maxillary and is the rudi- Fig. 38.-Nerves of nose and sphenopalatine ganglion, from inner side: 1, Network of external branches of olfactory nerve; 2, nasal nerve, giving its external branch to outer wall of nose; the septal branch is cut short; 3, sphenopalatine ganglion; 4, ramification of large palatine nerve; 5, small, and 6; external palatine nerve; 7, inferior nasal branch'; 8, superior nasal branch; 9, nasopalatine nerve cut short; 10, Vidian nerve; 11, great superficial petrosal nerve; 12,great deep petrosal nerve; 13, the sympathetic nerves ascending on internal carotid artery. ment of the nasal turbinate of the lower animals. Beneath the turbinated bodies are their respective meati: the superior, middle, and inferior meati. The inferior meatus extends back- ward and downward, and at the junction of its anterior third with the posterior two-thirds receives from beneath the inferior turbinated body the secretions of the eye through the nasal duct (Fig. 69). Its position upon the floor of the nose renders the inferior meatus the important drainage fossa of the nose, and along it the spray of an atomizer or the stream of a syringe should be directed if it is desired to wash secretions into the 60 DISEASES OF THE NOSE, THROAT, AND EAR pharynx. Above the inferior turbinated body is the middle meatus, and because of the numerous ostea opening into it is an important fossa in nasal diseases. The superior turbinated body is a portion of the ethmoid separated from the middle turbinate by a groove, the superior meatus, closed in front, but opening posteriorly into the spheno-ethmoidal recess. The nasal cavities are divided into vestibular, respiratory, and olfactory regions, and the accessory cavities. The vestibular region is all that portion of the nose anterior to the turbinated bodies. The respiratory region is the inferior nasal chambers posterior to the vestibular region, bounded above by the inferior edge of the middle turbinated body. Through this region of the nose the respiratory air-currents arch on their way to and from the pharynx. The olfactory region lies above the inferior edge of the middle turbinated body and the space between the middle turbinate and the sep- tum is the olfactory slit. At birth the hard palate is on a level with the junction of the sphenoid and basilar process; at three years it is opposite the middle of the basilar process, and at six years, as in the adult, opposite the anterior edge of the foramen magnum. The mucous or Schneiderian membrane of the nose is a continuation of the external tegument, and is continuous with that of the pharynx, the Eustachian tubes, and the accessory sinuses. It is sometimes called the pituitary (meaning phlegm- producing) membrane or the Schneiderian, after Schneider, an anatomist, who first proved that the nasal secretions were pro- duced by it and not by the brain. In many portions of the nose it is thin and inseparable as a membrane from the periosteum or perichondrium beneath, but over the inferior turbinate and the adjacent portion of the septum, as well as the inferior edge of the middle turbinate, it is thick and vascular. In these regions is the so-called erectile tissue, somewhat similar to that of the sexual organs, consisting of cavernous blood-vessels im- bedded in cellular tissue. When this tissue erects itself, that is, when its vessels fill with blood, the bulk of the nasal mem- ANATOMY OF THE NOSE 61 brane enormously increases and may cause almost complete stenosis of the nasal chambers. The vestibular mucous membrane is covered by stratified pavement epithelium and contains sweat and sebaceous glands, and anteriorly vibrissae or short hairs that serve to prevent the entrance into the nostrils of coarse particles of dust and insects. The mucous membrane of the respiratory region is covered by pseudostratified ciliated epithelium and contains goblet-cells. Mucous, serous, and lymphatic glands are numerous. The mucous membrane of the olfactory region contains no erectile tissue and to it are distributed the specialized nerve-endings of the olfactory nerve. It is covered by a single layer of cy- lindric epithelium and contrasts by its yellow color with the bright pink of the parts below. In this thin pale membrane are the olfactory and sustentacular cells capable of receiving sensory impulses recognized as odors. The arteries of the nasal fossae are the anterior and posterior ethmoidal from the ophthalmic, the sphenopalatine branch of the internal maxillary, and the alveolar branch of the internal maxillary to the antrum. The nerves of the nasal fossae (Fig. 38) are the nasal branch of the ophthalmic to the septum and outer wall, anterior branch of the superior maxillary to the inferior turbinated body, and the floor of the nose. The sphenopalatine ganglion gives off the Vidian nerve to the septum and superior turbinated body and the superior nasal branch to the same regions, the nasopalatine to the middle of the septum, and the anterior palatine to the middle and lower turbinates. The olfactory or first cranial nerves from the olfactory bulb enter the nose through twelve or more openings in each side of the cribriform plate. They are distributed to the specialized nerve-endings in the mucous membrane of the superior turbi- nate and a corresponding small region of the septum. The lymphatics of the nose are numerous. The more an- terior terminate in the submaxillary glands, the posterior com- municate with the pharyngeal glands. Hence the not uncom- 62 DISEASES OE THE NOSE, THROAT, AND EAR mon slight inflammation of the tonsils and cervical lymphatics after nasal operations. PHYSIOLOGY AND PATHOLOGY OF MUCOUS MEMBRANES During respiration through a normal nose the bulk of the air passes along the septum above the inferior turbinated body, describing a semicircle in its course, smaller currents extending upward nearly to the roof of the nose. However, a consider- able volume of air passes through the inferior meatus, eddying downward from the main current above the inferior turbinate and circling backward along the inferior meatus. The di- rection of the breath current is largely due to the horizontal position of the anterior nares, and because of the vertical po- sition of the posterior nares the expiratory current is by no means as complicated as the inspiratory. It simply spreads out like a fan in its passage through the nose and, hence, a larger volume of air passes through the olfactory region during expiration than inspiration, a fact that doubtless has an im- portant bearing on the appreciation of the flavor and odor of foods during mastication and swallowing. It is understood, of course, that the respiratory path changes with the shape of the nasal chambers. Abnormal dryness of the nasal mu- cous membrane, or nasal obstructions of a kind to interfere with the free access of air to the olfactory portion of the nose, interfere greatly with the acuteness of the sense of smell. The nose also serves as a resonant cavity during vocaliza- tions, so that obstruction of the nasal chambers produces a peculiar nasal intonation during speech. Perhaps the most important function of the nose is to warm, moisten, and free from the dust inspired air. In health exhaled air has a tem- perature of 98.5° F., and it has been proved experimentally that most of the heat supplied to inhaled air comes from the nose, the turbinated bodies being well adapted not only to warm the inspired air, but to moisten it and free it from particles of dust which adhere to its moist, sticky surface. ANATOMY OF THE NOSE 63 Dust particles removed from the skin of the face and from the vibrissae contain numerous bacteria from which cultures can be made. On the other hand, bacteria removed from the surface of the normal nasal mucous membrane evince little vitality and cultures are made from them with considerable difficulty. Hence it has been claimed that the nasal secretions possess sufficient antiseptic qualities to destroy some bacteria and inhibit the growth of others. The practical point from this is that irritating antiseptic sprays before an operation are un- called for, and by setting up what might be called a chemic rhinitis tend to promote the growth of bacteria rather than destroy them. This is particularly true of solutions of corro- sive sublimate. In inflammation of mucous membranes the secretions are either increased or decreased in quanity, so as to either flood the parts or leave them unnaturally dry. It should be borne in mind that the normal secretion of the nasal mucous mem- brane is over 16 ounces of clear watery mucous in twenty-four hours, a part of which in health passes unnoticed through the nasopharynx down into the esophagus and stomach. Only when by obstruction or irritation, due to any cause whatever, this easy outflow and abundant secretion is interfered with, do we perceive a thickening and an accumulation of mucus, which is composed largely of epithelial cells in a state of fatty degeneration, mucous corpuscles, and the impurities from the inspired air. When mixed with pus or blood the secretions become yellow, green, or brown in color; and if retained upon the mucous membrane for a sufficient length of time the secretions become offensive as the result of putre- factive changes. "Catching cold" is the result of a transient influence upon the vasomotor system of nerves, producing an uneven distri- bution of blood in the capillaries, especially manifesting itself as a congestion of the mucous membrane of the upper respiratory tract, followed in most instances by inflammation, swelling, and excessive secretion which then becomes infected by bac- 64 DISEASES OF THE NOSE, THROAT, AND EAR teria. It is probable that the phenomena of "catching cold" is largely of a reflex nature in which the peripheral sensory nerve fibrillae of the skin and extremities perceive the abstrac- tion of heat as a shock, and being afferent in their conductive function, convey the impression to their respective ganglia, whence it is reflected by means of the efferent vasomotor fas- ciculi to the vessels, causing their dilatation'and congestion, and, finally, inflammation of the structures containing them. This theory not only explains the ordinary phenomena of a "cold in the head," but also the pain of neuralgia and rheu- matism suddenly produced by "catching cold." Dilatation of the vasonervorum, resulting perhaps in the effusion of serum, produces pressure upon a nerve within its sheath and conse- quent pain in the muscle or skin containing it. The reason why the mucous membrane of the upper air- passages is the most frequent seat of an inflammation due to cold or a chilling of the surface of the body is that the sudden change of temperature produces, in the first place, an effect upon the sensory nerve-fibers in the skin, which impression is communicated to the vasomotor centers, and consequently results secondarily in a contraction of the blood-vessels of that portion of the skin which has been affected with a correspond- ing dilatation at some portion of the vascular system least able to resist the pressure. Inasmuch as our variable climate, the impurities of the atmosphere, and our artificial way of living have a tendency to weaken the capillaries of the upper air- passages from early childhood, that portion of the human economy is, therefore, the region most liable to suffer from this unequal distribution of blood. There results, first, engorge- ment of the parts, increased secretion and, finally, inflammation. However, frequently recurrent coryza is often only one of the manifestions of the sluggish elimination of waste products and toxins which when excreted through the nose cause irri- tation and swelling of its mucous membrane. In certain in- dividuals an error in diet is promptly followed by an attack of coryza. Under such circumstances, local treatment should ANATOMY OF THE NOSE 65 be supplemented by a carefully ordered diet and more impor- tant still, salines in sufficient quantities to secure daily copious evacuations. INFLAMATION OF MUCOUS MEMBRANES The most common forms are acute and chronic catarrhal in- flammation, purulent, croupous, and diphtheritic inflammation. In acute catarrhal inflammation an increased blood-supply stimulates the epithelial layer of the mucous membrane to in- creased activity; new cells are rapidly formed and cast off, while the glands pour out their secretion in excessive quantities and an abundant liquor sanguinis transudes the vessels, the mucous membrane at the same time appearing red and swollen. Chronic catarrhal inflammation differs from acute catarrhal inflammation in that the subepithelial layer of the mucous mem- brane is more involved. Connective tissue is developed by a slow process of proliferation. Usually the mucous membrane is thickened and hypertrophied; but, in some instances, the new tissue may be so placed as to press upon the glands and follicles, giving rise to atrophy. Also in catarrhal inflammation of the mucous membrane there sometimes occurs increased activity in the lymphoid cells, finally producing hypertrophy of the tonsils or other adenoid structures. Activity of morbid processes, confined largely to epithelial and lymphoid structures, belongs essentially to the younger period of life; while morbid activity in the connective-tissue structures belongs essentially to later life, rendering it much more difficult to bring about a cure in the catarrh of an adult than in that of a child. Croupous inflammation is of a higher grade than catarrhal; for, while it commences in the same manner, with increased blood-supply, rapid cell-growth and proliferation, increased secretion, and a throwing off of immature cells, leukocytes, and liquor sanguinis, it differs from it in the fact that the exudate contains a large amount of fibrin and albumin, which coagulate upon the surface of the mucous membrane, forming a false mem- 66 DISEASES OE THE NOSE, THROAT, AND EAR brane. This false membrane is at times so soft and almost granular in character as to be easily removed with a soft brush. At other times it is tougher and difficult of removal; but in either case, when removed, the mucous membrane is left intact or only deprived of some superficial epithelial cells. Diphtheritic inflammation is also characterized by the forma- tion of a false membrane, but its pseudomembrane permeates the mucous membrane so densely that it can only be removed by bringing away with it the entire thickness of the mucous membrane to which it is attached, thus leaving the parts below completely denuded. A diphtheritic pseudomembrane is of a dark grayish color, resembling somewhat an ordinary slough of the mucous membrane, in contradistinction from a croupous membrane, which is of a bluish-pearl color, with no appearance as of sloughing of the parts. DISEASES OF THE NOSE Effect of Diseases of the Nasal Passages on Other Parts of the Body.-Nasal disease may extend to the pharynx, ear, or larynx by continuity of structure, or affect the other respiratory organs by abeyance of the functions of warming, moistening, and filtering the inspired air, so that it enters the pharynx cold, dry, and dust-laden. Chronic pharyngitis and laryngitis frequently result from this cause; and while it is not easy to prove that pneumonic phthisis is indirectly the result of atrophic rhinitis, yet it is difficult not to suspect some such relationship. As the result of nasal disease there are often induced certain reflex phenomena, viz., nasal cough, nasal asthma, nasal vertigo, nasal epilepsy, nasal chorea, hay-fever, pareses of the palate and larynx, neuralgia and headache, reflex skin rashes, affections of the eye; both inflammatory, and muscular; amblyopia, suppuration of the orbit, and men- ingitis by infection from suppurating accessory nasal sinuses. The reflexes which originate in nasal or nasopharyngeal irritation and terminate in cough, laryngeal spasm, or asthma, DISEASES OF THE NOSE 67 follow much the same pathway as the reflex known as sneezing. The nasal branches of the ophthalmic division of the fifth nerve and the nasal branches of the anterior palatine descending from Meckel's ganglion, which is in connection with the superior maxillary division of the fifth nerve, conduct the sensory im- pressions to the medulla. It is there reflected to the respiratory, pneumogastric, and other centers; whence the deep inspiration, the forced expiration, and the coincident spasm of the pharyn- geal and laryngeal muscles, termed a sneeze. Acute rhinitis is an acute catarrhal inflammation of the nasal mucous membrane. Etiology.-It is generally the result of exposure to cold and wet when the body is overheated. It may, however, be pro- duced by breathing hot dry air or inhaling irritating vapors and dust, errors of diet, or come on apparently as the result of a ven- ereal debauch. Chronic catarrh, syphilis, rheumatism, dys- pepsia, or a debilitated state of the system renders an individual more liable to attack. The bacteria most commonly found in the discharges are: (i) Bacillus influenzae, (2) B. leptus, (3) B. of Friedlander, (4) Micrococcus cartarrhalis, (5) M. paratet- ragenus. The more chronic form of the disease has practically always the Bacillus of Friedlander in its discharges. Allen, by injecting appropriate doses of opsonic vaccines corresponding to the bacteria found in the discharges of acute rhinitis, succeeded in hastening convalescence; and in some cases apparently es- tablished an immunity from colds by the injection of opsonic vaccines. On the other hand, Rossbach observed that in rabbits, when the trachea was opened and ice applied to the abdomen, after a short period of pallor, the mucous membrane reddened and finally took on the dusky hue resulting from venous congestion. These appearances he attributed to the reflex from the skin acting on the vasomotor system in such a manner as to first produce contraction, then dilatation, and finally paralysis of the vessels of the mucous membrane with altered secretions and other symptoms of inflammation. He believes that only after the resistance of the mucous membrane 68 DISEASES OF THE NOSE, THROAT, AND EAR is thus decreased do bacteria find a suitable culture media in the altered secretions; and hence are not the initial cause of the inflammation. Pathology.-At first the mucous membrane, though swollen and congested, is dry. As the disease progresses, there is an abundant serous discharge, which becomes more and more charged with broken-down epithelial cells, lymph-corpuscles, pus-globules, etc., until the discharge assumes the character of thick tenacious mucous or mucopus. The deeper lying tis- sues also participate in the process. The erectile tissue be- comes gorged with blood and swollen, in some instances com- pletely occluding the nares. Symptoms.-The onset may be simply an attack of sneezing, followed by increased and thickened discharges. In other cases the attack begins with chilly sensations and a general feeling of illness. There is a sensation of fulness and pain about the nose and forehead. The face may be flushed, the eyes suffused, and more or less fever be present. Sensations, almost suffocating in their character, may be present from occlusion of the nares, and the discharges be so irritating as to scald the skin of the alae and upper lip. A cold in the head lasts from two or three days to as many weeks. It generally ends in complete resolution, but frequently repeated, is a common source of chronic nasal catarrh. In nursing children the child takes nourishment only with difficulty, frequently pausing to breathe through the mouth. Treatment.-A cold in the head can often be aborted at its commencement by a hot bath and a bowl of hot lemonade at bedtime, with or without io gr. of Dover's powder, followed in the morning by a saline purge and the wearing of extra warm clothing. The turgescence of the nasal mucous membranes and discharges can always be abated by the application of a 2 per cent, solution of cocain. This effect of the cocain can be kept up for several hours by spraying the interior of the nose with a 2 per cent, solution of antipyrin immediately after the application of the cocain solution. If repeated every day this treatment DISEASES OF THE NOSE 69 gives great and immediate comfort to the patient and cuts short the course of the disease, while a soothing snuff (Formula 115), used by the patient in the intervals between the applica- tions, adds much to the efficiency of the treatment. In severe cases the patient had better remain in bed, and the presence of fever requires the administration of aconite in small doses at frequent intervals. Many pill makers manufacture what they term rhinitis tablets, the active ingredient of which is atropin; gr. °f this drug, taken every two hours for four or five doses or until a sensation of dryness in the throat is produced and then at much longer intervals, yields decided relief in control- ling the nasal symptoms; but in some individuals produces headache, a hot dry skin and throat; and general discomfort. Simple chronic rhinitis, turgescent rhinitis, is a catarrhal inflammation of the nasal mucous membrane, exhibiting but a slight tendency to spontaneous recovery. Turgescent rhinitis is a recurrent swelling or turgescence of the erectile tissue at irregular intervals, mostly at night. The parts may appear nearly normal between attacks. Etiology.-It is generally the result of uncured rhinitis or frequent attacks of coryza. Pathology.-The mucous membrane of the nose presents pre- cisely the appearance seen in acute rhinitis, only it is less swollen and less red in color. The discharge is either watery, if the upper parts of the nose, especially the mucous membrane of the middle turbinated bodies are the parts most affected, or it approaches mucopus in character if the disease is mostly located in the lower parts of the nose. The symptoms are precisely those of acute rhinitis, only less pronounced. There is a feeling of fulness about the nose. There is alternating stenosis as the result of turgescence of first one nasal chamber and then the other, a continual dis- charge, and the sufferer is continually "catching cold," when, of course, all his symptoms are increased in severity. Prognosis.-'Untreated, chronic rhinitis may continue indefi- nitely, and finally result in hypertrophic rhinitis, the pharynx 70 DISEASES OF THE NOSE, THROAT, AND EAR also gradually becoming affected. Under treatment a cure is frequently brought about in from three to six weeks. Treatment.-'Ordinarily the tone of the system is below par and a tonic is indicated. In such cases Formula 137 answers a useful purpose. If the bowels are sluggish, it is advisable to direct the occasional use of a saline cathartic. Cleanliness of the mucous membrane is of primary importance, and may be secured by the patient using at home, twice a day, a bland alkaline wash (Formulas 1, 2, 3, 4, 5) with an atomizer. The application of an alterative or an astringent to the nasal mucous membrane in these cases is of greatest value, and the following formula has long been popular for this purpose: 1$. lodini, gr. v; Potassii iodidi, gr. xv; Glycerinae, f g ij.--M. The result of the application varies according to the amount of the solution used. When the nose is extremely sensitive, only a small amount of cotton should be wrapped about the applica- tor, so as to form a brush capable of absorbing but a small amount of the solution, which should be carefully applied to those portions of the nasal mucous membrane where the in- flammation seems greatest; the cotton brush should also be passed along the floor of the nose and the application painted upon the pharyngeal mucous membrane. After the appli- cation of the iodin solution the use of some protective upon the nasal mucous membrane is advisable. This indication may be secured by means of a spray of fluid albolene, applied until the mucous membrane of the nose and nasopharynx is thor- oughly coated with it. Instead of plain albolene, what is frequently referred to as menthol-camphor-albolene may be employed: Menthol, gr. v; Camphor, gr. xx; Albolene, fgij.-M. In certain cases either of the following formulas, when ap- plied to the nose, give quicker and better results than the iodin solution, espec ally in adults: DISEASES OF THE NOSE 71 1$. Argyrol. 10-25 Per cent. 1$. Boroglycerid. 50 cer cent. I}. Zinci sulphates, 2-4 per cent. I|. Acidi tannici, gr. xl; Glycerinae, fgj.-M. A case of simple chronic rhinitis is, then, perhaps best treated in the following manner: The patient is ordered a tonic, in- structed to wash out his nose night and morning with either Dobell's solution or one of its modifications, and to present himself at the physician's office at least twice a week, but better every other day, for treatment. After first cleansing the nose with a spray from an atomizer filled with an alkaline solu- tion, the physician should make an application of the required solution and follow it with a spray of menthol-camphor-al- bolene. Purulent rhinitis is an inflammation of the Schneiderian membrane in which the discharge from the beginning is puru- lent. It is more common in children. Etiology.-'It probably always results from specific infection of some kind. It may occur during the course of one of the exanthemata, diphtheria, etc. Some cases occurring in young infants are due to gonorrheal infection from the vagina during birth. Pathology.-'The bacteria characteristic of the infection are found in the discharge or in the mucous membrane. When suf- ficiently virulent to cause actual destruction of tissue, deep ulcers occur, with final formation of scar-tissue. This disease in childhood is probably the most common cause of atrophic rhinitis in after life. The adherents of the "Herd" theory believe that a chronic bilateral sinusitis is produced, which is responsible for the formation of crusts in the upper portions of the nose. Symptoms.-The disease is most common in children and is characterized by a fetid, thin, purulent discharge, sometimes streaked with blood, which often excoriates the lip and alae of 72 DISEASES OF THE NOSE, THROAT, AND EAR the nose. The nasal mucous membrane is red, swollen, and ulcerated. Treatment.-'The nasal mucous membrane should be cleansed at least twice a day with an alkaline spray. In infants the nose is more effectively cleansed by means of a syringe than by the spray from an atomizer, and the bulb rubber syringe (Fig. 28) is useful for this purpose. Extreme gentleness should be used in syringing, in order to prevent fluid entering the middle ear. In children who have not yet learned to blow their nose, it is best to blow it for them by in- serting the syringe tip into one nostril and forcibly compressing the syringe-bulb. By this means a current of air is forced into one nostril and out of the other, blowing the mucus and pus before it. After the nose has been cleansed of the secretion, with Dobell's solution, with a small quantity of gallic acid ointment, from 3 to 10 gr. to the ounce of vaselin, according to the age of the child, should then be placed within the nostrils with a brush. This home treatment should be car- ried out twice a day. The physician himself should treat the child two-or three times a week or oftener by cleansing the nasal mucous mem- brane as described above, using an air-douche either from a syringe or, in the case of larger children, the Politzer bag to blow mucus from the nose both before and after the use of the atomizer. When thoroughly cleansed, the nose should, be sprayed with albolene and dusted with powdered calomel or aristol by means of a powder-blower, care being taken that none of the powder reaches the pharynx and is swallowed. In scrofulous children hygienic measures are often as impor- tant as local treatment. Cod-liver oil, syrup of the hypophos- phates or iodid of iron being required in many instances. Membranous rhinitis is an acute inflammation of the nasal mucous membrane characterized by the formation of a pseudo- membrane involving the epithelial and sometimes the subepi- thelial structures. Etiology.-'The disease is most common among poorly DISEASES OF THE NOSE 73 nourished children living in unhygienic surroundings. Occa- sionally an adult is attacked. One of the writer's cases was a woman twenty-four years old. The disease is the result of inoculation of the nasal mucous membrane by a microorganism capable of generating in that locality a pseudomembrane; although it should be borne in mind that the sloughs resulting from galvanocautery wounds, either in the nose or on the tonsils, resemble very closely pseudomembranes; and the same is true to a certain extent of other nasal traumatisms. Pathology.-'The pseudomembrane is generally thick, pulpy, and grayish white, and during the earlier stages is removed with considerable difficulty, leaving a bleeding surface; later, it is more loosely attached and more easily removed. After each removal, if antiseptics are used, a smaller and smaller surface becomes again covered by exudate. The membrane is a meshwork of fibrin entangling leukocytes, degenerated epithelial cells, and microorganisms. Besides the Klebs- Lbffler bacillus, and that resembling it (Hoffman's bacillus), the streptococcus, staphylococcus, pneumococcus, and other microorganisms are capable of producing a pseudomembranous rhinitis. Symptoms.-The nasal mucous membrane is greatly swollen and that of the inferior turbinate and adjacent parts of the septum is covered by a pseudomembrane which sometimes involves other portions of the nose. The pharynx is usually almost completely free from pseudomembrane, or there may be one or more small patches, one of which may be on the tonsil. The sufferings of the patient are mostly those resulting from the occluded nostrils. However, the throat is generally some- what sore and the cervical glands, while not swollen, are tender to the touch and there is sometimes a slight elevation of tem- perature. Untreated the disease runs a course of from three to six weeks; under treatment, ten days to two weeks. Treatment.-'The pseudomembrane should be examined by a careful and competent bacteriologist for the presence of virulent Klebs-Lbffler bacilli, and if present, antitoxin should be 74 DISEASES OF THE NOSE, THROAT, AND EAR injected, the case isolated and treated as diphtheria; although primary nasal diphtheria usually runs a mild course, and the danger of inoculating other individuals is probably less than in faucial and laryngeal diphtheria. The writer has never seen an instance in which membranous rhinitis was apparently contracted from an individual similarly affected, although in some instances cases before coming under his care had attended school, and played or even slept with one of their parents or other children. In some of these cases the report of the bacte- riologist stated that the Klebs-Loffler was present. However, it is possible that in all these instances the cause of the pseudo- membrane was not the Klebs-Loffler bacillus, but that of Hoffman, which is morphologically identical and not an un- common inhabitant of the nose. As in the present state of our knowledge it is impossible to make a reliable differentiation between the Klebs-Loffler bacillus and that of Hoffman, except by guinea-pig inocula- tions or some similar test, requiring several days, and as anti- toxin, to be most effective, should be used within the first forty-eight hours after the onset of diphtheria, it is possibly better in recent cases, where the bacteriologist reports that the microscopic examination of "smears" show the presence of a bacillus possibly that of diphtheria, to at once inject antitoxin without waiting several days to determine the result of guinea- pig inoculations. In cases not seen before the pseudomem- brane has existed for a week or more, it is better to wait the result of guinea-pig inoculations, as in such cases the proba- bility of antitoxin doing much good is somewhat remote. In cases where the pseudomembrane is the result of the pres- ence of some other microorganism than the Klebs-Loffler bacillus, the use of antitoxin is manifestly not indicated. If the cervical glands are inflamed the skin of the neck over them should be kept covered by a io per cent, ointment of ichthyol in lanolin until the inflammation subsides. The medical attendant should see his patient at least once a day, and in older children pledgets of cotton saturated with a 3 per cent. DISEASES OF THE NOSE 75 solution of cocain should be inserted into each nostril, and after the turbinates have contracted the pseudomembrane should be withdrawn from the nose by means of Politzer's ear forceps (Fig. 167). After the use of cocain this is usually readily accomplished, especially in the later stages of the disease. After the removal of the membrane the nasal cavities should be washed with Dobell's solution by means of an atomizer yielding a coarse spray, or with a syringe. In very young children it is sometimes impossible to cleanse the nares thoroughly and the operator will be obliged to content himself by irrigating the nose by means of a medicine dropper -with Dobell's solution or other alkaline wash, to which a small proportion of hydrogen dioxid has been added. After the nasal cavities have been as thor- oughly cleansed as can be done with gentleness, the Schneider- ian membrane should be sprayed with a 10 per cent, solution of argyrol. Between the physician's visits the treatment should consist either in spraying the nose every three hours with a 10 per cent, solution of argyrol or the insertion into each nostril of an oint- ment of gallic acid, 3 to 10 grains to the ounce of vaselin, according to the age of the child. During the attack the child is probably best confined to the house, even in summer, although this is sometimes hard to accomplish when the child's temperature is normal and it feels entirely well except for the discomfort of nasal stenosis. In the more severe cases the child's condition may require that it remain in bed, and in such cases tincture of the chlorid of iron-• 5 to 10 drops in water every two hours-may be given with advantage, either with or without strychnin. The slight pharyngitis sometimes present yields to argyrol spraying, or the tonsils may be sufficiently inflamed to require one or more applications of a 10 or 15 per cent, aqueous solu- tion of nitrate of silver. Hyperplastic rhinitis and hypertrophic rhinitis are chronic inflammations, of the nasal mucous membrane and sub- 76 DISEASES OF THE NOSE, THROAT, AND EAR mucous tissues with permanent dilatation of the blood-vessels. Hypertrophy of an organ is due to an increase in the size of the cells, while hyperplasia is an increase in the number of cells. Both conditions imply an increase in bulk. In the turbinated bodies of the nose the conditions can be differen- tiated from the fact that in hypertrophy the parts are soft to the touch and shrink greatly under the application of cocain or adrenalin, while in hyperplasia the parts are firm to the touch and do not shrink greatly under cocain. Etiology.-These diseases are invariably the result of long- continued simple chronic rhinitis or frequent attacks of coryza. Pathology.-While in long-continued simple chronic rhinitis there is already some thickening of the epithelial layer of the mucous membrane, yet the disease only becomes hypertrophic rhinitis when the thickening involves the other elements of the mucous membrane and the submucous structures. As the result of frequent attacks of inflammation the blood-vessels become permanently dilated and their walls thickened, glandu- lar tissue is hypertrophied, hyperplasia occurs in the connective tissue, so that the thickened turbinates cannot collapse as when normal, and remain permanently distended with blood. This thickening is most noticeable at the anterior and posterior parts of the middle turbinated bodies, where it is called an anterior or posterior hypertrophy. Symptoms.-The most prominent symptoms are those of nasal obstruction, want of proper drainage from the nasal cavities, and increased secretions. When the obstruction is great and constant the patient becomes a "mouth-breather." The inspired air, under such circumstances, not being properly warmed, moistened, and freed from dust in its passage through the mouth, causes dry lips, a coated tongue, follicular pharyn- gitis, and sometimes chronic laryngitis. When the nasal occlu- sion is complete, the face assumes a stupid expression on account of the constantly open mouth. Should the habit of mouth-breathing be acquired in early childhood and continued for some years, the shape of the bones of the face is altered and DISEASES OF THE NOSE 77 the habit of mouth-breathing retained long after the nasal obstruction has disappeared. Any position favoring the gravitation of blood into the hyperemic or hypertrophied parts is sufficient to cause their distention; hence, when the patient is in bed, first one nostril and then the other will become occluded, according to which side of the body is lain upon. This is especially true when large posterior hypertrophies are present. Obstruction and suppuration of the nasal duct not infrequently occur as the result of inflammation beginning at it nasal orifice. An anterior hypertroohv of the middle tur- Fig. 39.-Anterior hypertrophy of the inferior turbinate (Seiler). binated body pressing on the septal nerve, a branch of the ophthalmic, frequently causes reflex eye-symptoms, such as chronic conjunctivitis, slight paresis of accommodation; and irritable retina occurs as the result of involvement of the eth- moidal labyrinth. The olfactory slit may become closed from hyperplasia of the middle turbinated body, and thus interfere with the sense of smell and that of taste to a corresponding degree. Redness of the tip of the nose and acne are also in some cases apparently the result of interference with the blood supply of the skin. Hearing may be gravely compromised from the pressure of hypertrophies interfering with the blood 78 DISEASES OF THE NOSE, THROAT, AND EAR supply of the Eustachian tubes, or the extension of the disease to their lining mucous membrane. Headaches are often com- plained of, and a feeling of pressure or even of pain at the root of the nose. The patient frequently complains thathehas "a bad breath." In many cases the offensive odor is due to decaying epithelium upon the tongue as the result of mouth-breathing or dyspepsia. At other times the "bad breath" of which the pa- tient complains is perceptible only to himself, and is probably due to irritation of the olfactory region of the nose, contrasting strongly in this respect with atrophic rhinitis. If any "catarrhal" odor " of the breath of an individual with hypertrophic rhinitis be present, it is always more annoying to himself than to a bystander. Treatment.-'Each case should be treated as one of simple chronic rhinitis until the inflammation of the Schneiderian membrane has disappeared, when operations should be undertaken for the removal of any tissue causing obstruction. Removal of Anterior Hypertrophies.-If large, especi- ally if the hypertrophy consists of hyperplastic tissue, that is, tissue that does not contract when cocain is applied, their removal with scissors or snare will be found most satisfactory. Another method of removing anterior hypertrophies is by the galvanocautery. A pledget of absorbent cotton, saturated with a 3 per cent, solution of co- cain, is introduced into the inferior meatus and al- lowed to remain in contact with the hypertrophy until it has shrunken as much as possible and the parts are thoroughly anesthetized. A metal specu- Fig. 40.-Jarvis' snare. The figure shows a small, light snare: what might be called the "standard" snare for nasal work. It should be forged from steel and not constructed of brass with a steel tip.. For ordinary nasal work it is threaded with No. 5 American steel piano wire, which, while not as strong, is somewhat more pli- able than the imported. _ However, many operators prefer Krause's snare or some similar type, which permits the same wire loop being used a number of times. DISEASES OF THE NOSE 79 lum is introduced after the removal of the cotton and the hypertrophy exposed. After the platinum wire of the cau- tery-knife is at a dull-red heat, it is placed upon the thick- est part of the hypertrophy, and by means of gentle to-and- fro movements is made to cut through to the bone, when it is carefully withdrawn, so as not to detach the eschar which it has formed. The operator should be careful to cut down to the periosteum before withdrawing his cautery-knife or the results of the operation will be far from satisfactory; for, although a superficial burn either with the galvanocautery or chromic acid heals very quickly and gives a certain amount of relief for a short time, yet the results are not as permanent as when the cautery-knife is made to penetrate the periosteum. No after-treatment is required beyond keeping the wound as dry as possible and endeavoring to avoid detaching the eschar before the healing process has been completed beneath it. Although nearly six weeks are sometimes required for the complete healing of a cautery wound, yet little inconvenience is usually experienced by the patient during the healing process, except that during the first week the nostril is sometimes more obstructed than ever as the result of swelling. At the end of about ten days the slough produced by the burning separates from the wound and decided advantage from the cauterization is then first experienced. The improved respiration becomes greater and greater until the wound is finally entirely healed. The anterior portion of the turbinate then presents a some- what pale appearance, with a depression indicating the seat of the cautery application. The turbinate not only is diminished in size, but sudden change in its volume, with consequent ob- struction of the nostril, is also prevented. The patient states he "does not 'catch cold' as readily as before the operation." The cautery should be used judiciously, as great and perma- nent injury may result from the work of a careless or brutal op- erator. Large tracts of mucous membrane may be destroyed by application of the flat side of the cautery-knife or the spread- 80 DISEASES OF THE NOSE, THROAT, AND EAR ing over a moist mucous surface of a chemic caustic. Such wounds heal slowly and some time elapses before the scar be- comes covered by an epithelium that functionates properly. The galvanocautery should be used cautiously upon the mid- dle turbinated bone, only a very small knife being employed for the purpose. Its application to the posterior portion of the nose is best avoided. Because of the thinness of the car- Fig. 41.-Fusing chromic acid on an Allen probe: a, Heating probe to redness; b catching up a crystal; c, heating to round into a bead; d, finished probe. tilaginous septum and the low vitality of its cartilage deep cautery wounds generally result in a perforation. Because of the edema that sometimes results the cautery should not be used on the uvula, the anterior pillars of the fauces, the aryten- oids, or the glosso-epiglottic folds except with extreme caution. It is permissible to remove a little mass of mycosis by means of the galvanocautery from these regions, but a very small cau- DISEASES OF THE NOSE 81 tery-knife should be employed and the burn should be very superficial. Chromic acid is more frequently employed than any other chemic caustic in the treatment of anterior hypertrophies. It should be used in the following manner: The end of an Allen probe (Fig. 41) is heated and plunged into a bottle containing crystals of chromic acid, some of which will adhere to the probe and be withdrawn with it from the bottle. A further applica- tion of heat will fuse these crystals upon the probe, which is now ready for use. The probe may also be prepared for use as a cautery by wrapping a few fibers of absorbent cotton about its end and rubbing into it moist powdered crystals of chromic acid until the cotton is saturated with the paste. The parts having been cocainized, the end of the probe, covered with chromic acid, is pressed firmly into the hyper- trophy and pushed backward and forward over the line to be cauterized, and finally withdrawn. After the lapse of a few moments the nasal chamber is thoroughly washed with the spray from an atomizer containing an alkaline solution, care Fig. 42.-Galvanocautery handle. being taken that none of the resulting chromic salt reaches the pharynx and is swallowed, as it is poisonous. Chromic acid is more uncertain in its action than the galvano- cautery-knife, and the same is true of trichloracetic acid, which is used in practically the same manner, except that, being a liquid, it cannot be fused on to the end of a probe. When the rhinologist's office is lighted from the wires of an electric supply station some form of ''converter " may be used to secure a current suitable for the galvanocautery, snare, minia- ture lamps, and electric motor. Apparatus also may be pur- chased for obtaining from the company's wires both a suitable galvanic and faradic current for medicinal purposes. 82 DISEASES OF THE NOSE, THROAT, AND EAR Removal of Posterior Hypertrophies-X Jarvis snare should be threaded with No. 5 steel piano wire. The loop of wire should be bent to one side before being introduced into the nostril, so that it may the more readily be passed around the hypertrophy and remain in position when the loop is tightened. Being made as small as possible without distorting it by pulling down the sliding tube upon the handle of the instrument, the loop is carefully intoduced along the floor of the nose until the poste- rior wall of the pharynx is reached when the loop is again en- Fig. 43.-Cautery-knives. larged by pushing upward the sliding tube, and the instrument at the same time is slowly withdrawn as its handle is carried toward the septum. By this means the wire is made to sur- round the hypertrophy and a resistance is finally felt as the instrument is withdrawn, caused by the bight of the loop coming in contact with the base of the hypertrophy. The wire loop is now quickly tightened around the hypertrophy by pushing forward the instrument within the sliding tube, and the milled nut is quickly screwed downward into place. Two or three additional turns are given to the milled nut to be certain that the wire is tight about the base of the growth DISEASES OF THE NOSE 83 and that the instrument is held firmly in place without danger of slipping, when the patient may be allowed to rest. The sudden tightening of the wire loop occasions the patient some pain, which, however, soon subsides, when the loop may be still further tightened by turning the milled nut until the pa- tient begins to again experience pain. In this way, proceeding slowly and carefully, the hypertrophy is finally squeezed off from its attachment, and is generally removed clinging to the end of the instrument by some fibers that have been drawn down into it with the wire. However, should the growth not be removed with the instrument, no attempt should be made to dislodge it from the nose, as it forms an efficient plug to pre- vent hemorrhage, and will probably drop into the fauces and be expectorated within twenty-four hours after the operation. Owing to the compression of the wire, the wound made by snar- ing a posterior hypertrophy is but small and generally heals rap- idly. Cocain should not be used as a local anesthetic for the removal of posterior hypertrophies, because it shrinks the tis- sues to such an extent that it is difficult to grasp the hyper- trophy with the snare. A io per cent, solution of stovain or alypin does not contract the tissues and hence is the preferable anesthetic for this operation. Turbinectomy, or removal of the whole or, at least, the greater portion of the inferior turbinated body, is performed to secure increased breathing space, for the removal of malignant growths, and for other reasons. Turbinotomy, or the removal of a por- tion of the inferior turbinate, by the snare, galvanocautery, and chemic caustics has been described already. When these methods are inadequate to remedy stenosis, a larger portion may be removed with a swivel knife (Fig. 63), which is applied as near the posterior extremity of the turbinate as deemed neces- sary and pushed upward through the tissues to the desired depth and then drawn forward parallel to the lower border of the turbinate, so that a long strip of tissue is cut away. The same result is accomplished with a "spoke shave," an instru- 84 DISEASES OF THE NOSE, THROAT, AND EAR ment similar to Fig. 63, except that its cutting edge does not swing, but is fixed and immobile. When sufficient nasal respiration can be secured by operations on the septum, such as the removal of an exostosis or bringing a septal deviation into the median line, it is better not to re- move any large portion of the inferior turbinated body because of the great destruction of mucous membrane and erectile tissue. Fig. 44.-Struycken's nasal alligator cutting forceps, for removing turbinates. Moreover, a turbinectomy done to relieve the stenosis caused by a deviated septum would accomplish nothing toward improving the condition of the wider nostril. As a matter of fact, when middle-ear catarrh results from deviation of the nasal septum, it frequently begins in the ear of the same side as the wider naris. The operation of turbinectomy is best done in the following manner: The nasal mucous membrane is cleansed with spray from an atomizer containing Dobell's solution or some other suitable alkaline fluid. The upper and lower portion of the attachment of the inferior turbinate is now cocainized by rub- bing into them by means of a cotton-tipped applicator a io per cent, solution of cocain in i to 2000 adrenalin solution. DISEASES OF THE NOSE 85 One blade of Struycken's cutting forceps (Fig. 44) or, better, a stout pair of nasal scissors (Fig. 45) is inserted beneath the anterior extremity of the turbinate in a direction upward and somewhat backward and the anterior attachment of the bone severed. The cutting is continued backward in a direction parallel to the floor of the nose until the inferior turbinate is completely severed from its attachment to the lateral wall of the nose. It is then removed with a pair of forceps. The hemorrhage is frequently trifling. It should be remembered that while the anterior attachment of the middle turbinate is nearly vertical, that of the inferior is obliquely upward and backward. Fig. 45.-Beckmann's scissors. Simpson's tampon or a longer strip of Bernay's sponge (Fig. 49) is inserted into the nostril, where it is allowed to remain for 24 hours. Ecchondroses and Exostoses of the Septum.-A localized cartilaginous thickening or projection from the cartilaginous septum is called an ecchondrosis, while a similar bony growth upon the bony septum is referred to as an exostosis or hyper- plastic osteoma. Heteroplastic osteoma is a name given to rather a rare form of bony nasal growth which springs from the cellular tissue beneath the mucous membrane, is not continu- ous with the cartilaginous or bony framework of the nose, and is, therefore, movable. Frequently, ridges or shelves of carti- lage and bone are found extending along the septum nearly from the anterior to the posterior nares. Usually such growths 86 DISEASES OF THE NOSE, THROAT, AND EAR follow the suture between the vomer and superior maxillary or that between the triangular cartilage and the vomer. (See Vomerine Crest, p. 86.) Etiology.-They are, doubtless, sometimes merely provisional callus that has escaped absorption and has been deposited upon an old traumatism of the septum, which may have been received during early childhood as the result of one of the num- erous "bumps upon the nose" that children are constantly receiving. Symptoms.-Frequent nasal obstruction. Atrophy of the turbinated body opposite them is not uncommon, nor neuralgia of the whole side of the face, as the result of intranasal pressure. Sometimes the crest of such growths is ulcerated, and a thin, irritating, sanious discharge results, impossible to cure except by the removal of the exostosis or ecchondrosis. The nostril being obstructed in front, the breath current is interfered with in such a way that there is a constant rarefaction of the air at the orifice of the Eustachian tube at each inspiration, and as the result of "vacuum congestion" tinnitus and, finally, otitis media and deafness result. Operations.-Localized thickenings of the cartilaginous sep- tum may be cut through and removed by means of a small probe-pointed tenotome. When the growth is hard and bony it is best removed by means of a chisel or saw. It should be borne in mind that only that portion of the growth should be removed which interferes with proper nasal respiration. This, of course, means, in most instances, the whole of the growth. In a roomy nostril, however, and in atrophic rhinitis the growth may in some instances be doing good by occupying a certain amount of space in a nostril already too large, and under such circumstances its removal would probably cause post- nasal catarrh and chronic pharyngitis. The parts to be operated upon should be exposed by means of a dilator (Fig. 17), which will be found convenient for operations within the nose, because when once in position it is not easily displaced by the struggles of the patient during an operation. DISEASES OF THE NOSE 87 The field of operation is then rubbed with a cotton-tipped probe which is moistened and dipped into coarsely powdered cocain. A i to 1000 solution of adrenalin is then applied in the same manner. When the saw is used, it should be entered below the growth and the sawing done in an upward direction, so as to obscure the field of operation as little as possible by blood, which, of course, flows downward from the wound. When the shelf of bone is large and hard the operation is necessarily tedious; but at any stage of the operation the saw may be withdrawn and both operator and patient rest, a plug of absorbent cotton saturated with a solution of adrenalin being inserted within the nostril. Under these circumstances the nostril will be found free from blood when the cotton is withdrawn, so that the operator can readily see to replace the saw in the cut al- ready made. It is possible in some instances to secure a prac- tically bloodless operation; but it should be borne in mind that adrenalin contracts only the more superficial vessels, and that if a large vessel is severed, especially one deeply im- bedded in bone, the hemorrhage may be severe. Under such circumstances the operation should be completed as speedily as possible and the severed mass of bone removed. A Simp- son nasal tampon (Fig. 49) should then be placed within the nose, but should this prove insufficient, the case should be treated as described in the section on Nasal Hemorrhage. A large variety of nasal saws are for sale in instrument stores. Those shown in Fig. 46 are typic as to arrangement of the teeth. The saw blades should be thin but rigid, and therefore some- what wide, especially near the handle. Occasionally a narrow saw is required to commence the sawing of an exostosis too close to the floor of the nose to permit the introduction of a wider instrument. To prevent binding in the tissues, the cutting edge of the saw should either be thicker than the back, as in metacarpal saws, or the teeth will require "setting," as in ordinary carpenters' saws. Clogging of the teeth with sawdust occurs in all saws, but is best prevented by the arrangement of 88 DISEASES OE THE NOSE, THROAT, AND EAR the teeth in the Sajous saw. Hence this saw penetrates hard bone more rapidly than the others and is a preferable instru- ment when an exostosis is large or much sawing has to be done, as in the author's operation for deviated septum. Hall's saws and the beveled saw blades of Pynchon are excellent for small soft exostosis. To avoid leverage the sawing should be done as much as possible with the teeth nearest the operator's hand, and the saw teeth should extend up somewhat closely to the handle of the instrument (Fig. 46, e). Fig. 46.-Nasal saws: a, Bosworth's saw. The three varieties have teeth which are either "straight cutting," "back cutting," or "front cutting"; 6, Buck- lin's saw. The teeth are arranged like those of a metacarpal saw; c, d, Hall's saws, right and left, are beveled on the cutting edge, so that these saws may be sharp- ened on a stone in the same way as a knife; e, Sajous' saw. Has teeth arranged like the double-handled large cross-cut saws used by lumbermen to saw logs. This arrangement of the teeth prevents them from being clogged by sawdust, and hence Sajous' saw penetrates bone more rapidly than the others. Not infrequently, after the bone has been completely severed, it will be found difficult to cut with the saw the shreds of mu- cous membrane by which it is still attached to the septum. These shreds usually can be easily cut with the nasal scissors. However, in most instances the snare (Fig. 40) is by far the preferable instrument. It is especially useful in cases where a small exostosis has apparently been completely severed, but has disappeared from view in the blood within the nose. In some of these cases it is difficult to locate and grasp the mass with forceps, and impossible for the patient to blow it from the nostril because of a shred or two of uncut membrane; under DISEASES OF THE NOSE 89 these circumstances if the wire loop of a snare is passed beyond the position of the exostosis and then kept closely in contact with the septum, the loop will hardly fail to encircle any shreds that still connect the exostosis to the septum, and after these are severed by closing the loop the exostosis usually is with- drawn from the nose with the snare by means of fibers that have been drawn into the tube of the snare. Ecchondroses, occupying only the anterior portion of the septum, are best removed by a submucous operation, which is readily done by incising the mucous horizontally along the crest of the growth and elevating that above the crest with a probe-pointed tenotome. No attention need be paid to the mucous membrane below the crest, as that above is usually sufficient to cover the wound. The cartilage or bone is then removed with knife or saw and the mucous membrane re- placed over the wcund. Except that such wounds heal more quickly than when the mucous membrane has not been sacri- ficed, the method has no advantages except at the extreme anterior portion of the septum. In this locality the removal of much mucous membrane is often followed by annoying crust formations which may persist for many months or years. Drills.-The motive power for the drill is supplied through a flexible armpiece (such as is used by dentists) by a small electro- motor. The operation with the drill is performed in the following manner: After cocainization of the field of operation as already described, a trephine sufficiently large to remove at once the major portion of the exostosis is selected, and with its shield is adjusted to the armpiece of the electric motor in such a manner that the shield will protect all parts of the nose from injury except those to be cut away. The teeth of the trephine are now pressed into the anterior part of the growth, and as the instru- ment is pushed forward a piece of bone is cut from the exostosis, which enters the cavity of the trephine, where a knife set at an angle cuts it into pieces sufficiently small to pass through a fenestra made for this purpose. Should a sufficient amount 90 DISEASES OF THE NOSE, THROAT, AND EAR of the growth not be removed by the first passage of the tre- p'hine through the nasal fossa, the trephine may be reapplied as often as may be necessary to remove the entire exostosis and leave a smooth, flat surface like that made by a saw. When an ecchondrosis or exostosis has attached itself to the inferior turbinated bone, so that a synechia or "bridge" extends from the septum to the opposite side of the nostril, it is perhaps best removed by first sawing through the portion next the septum, then snaring the attachment to the turbinate. Unfortunately, after such an operation the "bridge" is very liable to recur, owing to the granulations from the cut surfaces Fig. 47.-Gleason's electric-motor drill. of each side of the nostril approaching each other during the healing process until they finally unite. To prevent this dis- aster, a steel probe may be used to break down the adhesions, or a piece of tin-foil or gutta-percha may be worn inside the nose between the cut surfaces until the healing process is complete. Ordinarily, nasal operations, either with saw or chisel, reqiure no after-treatment beside the free use of an alkaline wash by the patient, in order to keep the wound clean. There is but little inflammatory reaction and the wounds heal promptly. Packing the nose with iodoform gauze or any other substance after a nasal operation should be avoided if possible. It is only permissible to check hemorrhage or when the patient has to travel a considerable distance after leaving the surgeon's office before reaching home. Under such circumstances a narrow strip of iodoform gauze, previously saturated with fluid albo- lene, should be placed in the nose in such a manner as to make gentle pressure upon the wound. Such a packing can generally be removed without hemorrhage, in from twelve to twenty-four hours, if care is taken to remove it gradually, so as not to remove the pressure from the wound too suddenly. When no dressing is used, which is by far the preferable DISEASES OF THE NOSE 91 method, blood-stained mucus is blown from the nose for some days after the operation. Atrophic rhinitis is an atrophic condition of the nasal mucous membrane, usually also of the submucous tissues, and the tur- binated bones and septum. In some cases because of a faulty development of the shape of the nose the nostrils look forward instead of downward. The disease is characterized by a les- sening in the size and thickness of the intranasal anatomy, a change in the color of the mucous membrane, a replacement of ciliated by squamous epithelium, and partial loss of function as the result of a decrease in the number of component cells, hence diminished secretion and the formation of crusts of inspis- sated and putrid mucus which emit a fetid and offensive odor. Etiology.-Atrophic rhinitis is said to result from long-con- tinued hypertrophic rhinitis, but the author never observed hypertrophic rhinitis assume the atrophic form except in a syphilitic; where, after the loss of the major portion of the septum, the nose presented a characteristic atrophic appear- ance, with loss of the sense of smell and fetid crust formation. Meissner states that atrophic rhinitis is the result of ^'primi- tive" or broad shallow nose, and to congenital development of pavement instead of columnar mucus-producing epithelium. An abnormal dryness of the atmosphere, like that produced by hot-air heaters, abnormal patulency of the nares, or any- thing else that causes a rapid evaporation of the nasal secre- tions, tend to produce atrophic rhinitis. In many instances the disease begins in childhood as a purulent rhinitis. Any infection with bacteria virulent enough to cause destruction of the nasal mucous membrane over comparatively large areas will produce atrophic rhinitis. Probably a majority of cases are the result of the destruction caused by pseudomembranous rhinitis and nasal diphtheria. Suppuration of the accessory sinuses may result from atrophic rhinitis or, according to Hurd and others, produce the disease. There is said to be present in most cases the bacillus fcetidus ozaenae, which was formerly thought the cause of the disease. Bacteria of various kinds 92 DISEASES OF THE NOSE, THROAT, AND EAR swarm in the semi-putrid, half-dried secretions, and the stench is either directly the result of such masses, or may originate from the contents of suppurating accessory sinuses. Pathology.-As the result of the increased size of the nasal chambers the scanty secretions rapidly evaporate and, mixed with the inhaled dust, accumulate upon the mucous membrane, forming bad-smelling scabs and crusts. Owing to pressure from these scabs, shallow ulcers occur beneath them, while the atrophy progresses by the destruction of glands, nerves, blood- vessels, connective tissue, and bone until, in some cases, the tur- binates have nearly disappeared and the septum has become, at certain parts, almost as thin as a sheet of writing paper. It is not uncommon for individuals to present themselves to the surgeon with hypertrophic catarrh existing in one nasal cavity, while atrophic rhinitis is present in the other. In such cases there is usually deviation of the septum toward the hyper- trophic side. Cases are not infrequently seen with an inferior turbinated body and the adjacent mucous membrane atrophied, while the middle turbinated body immediately above is greatly hypertrophied. Concomitant disease of the ethmoid cells or of some one or more of the other accessory sinuses of the nose is not uncommon in atrophic rhinitis. When superficial necrosis results from bacterial infection the progress of the disease, after the forma- tion of ulcers, is similar to that described above. Retained secretions putrefy and produce a characteristic odor, horribly offensive, the disease being then termed ozena. Similar stenches occur in syphilitics, the stench resulting usually not from fetid semi-inspissated mucus, but from sequestra of dead bone within the nose. Somewhat numerous varieties of bacteria are found in the secretions of atrophic rhinitis, the saprophytes, or those causing putrefaction, naturally being the most numerous. The Klebs-Lbffler bacillus or that of Hoffman is frequently found. Attention has not infrequently been called to the large proportion of cases of pulmonary tuberculosis among patients DISEASES OF THE NOSE 93 with atrophic rhinitis; for instance, Theisen reports 14 cases of pulmonary tuberculosis among 40 cases of ozena examined. It has been suggested that the large proportion of consumptives is due to the fact that atrophic rhinitis deprives the nose of its power to arrest and destroy the bacteria of inspired air. Symptoms.-A sensation of dryness and irritation within the nose and pharyngeal vault, with almost constant efforts to re- move the accumulated secretions by hawking, spitting, and blowing the nose. The breath is usually fetid, but the patient, because of his defective sense of smell, is unaware that his breath is horrible offensive. Upon inspection, the mucous membrane is found dry and glazed, with scabs and pus adher- Fig. 48.-Allen's nasal applictor with Gottstein's cotton plug ready to be deposited inside the nose. After the cotton is within the nose the probe is detached from the cotton and withdrawn by turning it in a direction opposite to that by which the cotton was wrapped. ing to certain portions of it. Sometimes the nostrils are so patulos that the posterior pharyngeal wall can be plainly seen through them, and it also is usually in an atrophic condition. Yet, notwithstanding the patulos nares, patients usually com- plain of an inability to breathe through the nose. Reflex skin rashes, pharyngitis and laryngitis are very common as the result of this affection. Anemia frequently results from the obsorption of septic material and loss of the respiratory func- tions of the nose. Treatment.-The indications are to secure and maintain ab solute cleanliness of the nasal mucous membrane, and replace, if possible, the atrophied parts. Cleanliness may be secured by syringing with an alkaline wash. When the patient is wearing Gottstein's cotton cylinders within the nose there is usually no trouble in removing the secretions, as crusts usually cease to form. The best results are obtained in the treatment of atrophic rhinitis by the use of absorbent cotton, as first advocated by Gottstein (Fig. 48), so placed inside the nose as to perform the 94 DISEASES OF THE NOSE, THROAT, AND EAR functions to a certain extent of the atrophied turbinated bodies. If pharyngitis sicca is present, the cotton cylinders should be of sufficient length to extend the entire length of the nasal floor and project somewhat from the posterior nares. The presence of the cotton cylinders excites the atrophied mucous membrane to renewed action, so that the dried secretions are washed away in the increased discharge and the fetor of the breath corrected. The cotton cylinders soon become soaked with mucus, so that the air passing around them is warmed, moistened, and freed from dust, and enters the pharynx and larynx as if it had passed through a healthy nose. This is the result partly of mechan- ical irritation and partly of the refraction of the inspired air- a factor that should not be overlooked in the treatment of atro- phic rhinitis, as irreparable damage results from the removal of an exostosis, especially if located well forward. A cotton cylinder is easily made by loosely wrapping absor- bent cotton about an applicator (Fig. 48) until it has assumed the desired bulk and shape. The cotton is then placed inside the nose and the applicator removed by turning it in a direction opposite to that by which the cotton was wrapped about it. The patient should be taught how to make and place these cotton cylinders inside his nose, and should insert fresh ones as soon as the old are removed by the use of the handkerchief. If worn constantly they cause an immediate change for the better in all the symptoms. However, a very large proportion of patients are unable to properly use this cotton. The condition of the accessory sinues should be carefully in- vestigated, and if diseased, should receive appropriate treat- ment. If practical, the patient should adopt an outdoor em- ployment away from dust and, if possible, near the seashore. Diphtheria antitoxin has been injected subcutaneously under the impression that the disease was due to the presence of the Klebs-Loffler bacillus in the nose or accessory sinuses. The temporarily good results reported were probably due to the stim- ulating effects of this substance on mucous membranes rather than to bactericidal action. DISEASES OF THE NOSE 95 So numerous are the drugs that have been used in the local treatment of atrophic rhinitis that a catalogue of their names and combinations would fill several pages. Among the best is sarlet red ointment. As most drugs and formula that are anti- septic and slightly stimulating afford at least temporary relief, the composition of the remedy is probably of much less impor- tance than the thoroughness with which it is applied to the angles beneath the remains of the middle turbinates and other not readily accessible parts of the nose. Nitrate of silver solu- tions have been used for many years in the treatment of atrophic rhinitis and at the present time there seems a tendency to return to their employment. After the nose has been cleansed of crusts, an applicator with a small, somewhat firmly wrapped piece of cotton is dipped into a solution of nitrate of silver and after being freed from drip is pressed into all accessible portions of the upper portion of the nose, especial attention being directed to locations in which accumulations occur. In such places the remedy is massaged, as it were, into the tissues by recur- rent pressure with the applicator; 2 up to 15 per cent, nitrate of silver may be used, but when the stronger solution is em- ployed, great care should be taken that there is no drip ex- pressed from the cotton to reach the pharynx and larynx. Attempts have been made with no great success to restore the original bulk of the turbinals by the injection of paraffin wax (Formula 85) underneath the nasal mucous membrane. The average case of atrophic rhinitis without disease of accessory sinues is best treated in the following manner: At the first office visit the nasal and nasopharyngeal mucous mem- brane is thoroughly cleansed and all adherent masses removed. Nitrate of silver solution (2 per cent.) is then thoroughly applied to the entire surface and carefully worked into all angles and spaces, such as those about the remains of the turbinated bodies. At the third or fourth office visit at intervals of three or four days the mucous membrane will have assumed a more normal appearance, and the patient should be taught to make and in- sert Gottstein's cotton cylinders. 96 DISEASES OF THE NOSE, THROAT, AND EAR As soon as he has learned to do this properly and cleanse his nose efficiently the office visits should be made at less frequent intervals. He is ordered for home use a wash and instructed how to use it with a syringe. After cleansing the nose he should apply twice a day, by means of a brush, iodin, potassium-iodin-gly- cerin (Formula 112). If pharyngitis sicca and laryngeal symp- toms are very annoying small doses of iodid of potash (gr. ij to iv, t. i. d.) or syrup of hydriodic acid may be ordered with ad- vantage, to increase the secretions. Prognosis.-'Atrophic rhinitis is one of the most unsatisfactory and tedious of nasal diseases to treat. Fetor of the breath and the other more annoying of the patient's symptoms are easily and quickly corrected in the majority of cases by wearing Gottstein 's cotton cylinders, and something very like a cure of the disease after some years, will be finally brought about. The writer occasionally sees cases that he treated ten or more years ago. Some of these cases are cured to the extent that there is no fetor of the breath or retained secretions requiring removal, except during periods when the patient has caught cold. Others of these cases still wear the cotton cylinders, although not constantly, and by this method and by the use of nasal washes manage to maintain a fair degree of comfort. In some cases there has been a partial restoration of the sense of smell. Syphilitic rhinitis is a diseased condition of the interior of the nose dependent upon the presence of syphilitic virus. Pathology.-It is exceedingly rare to find the primary lesion of syphilis existing inside the nose, from the fact that the syph- ilitic virus is rarely introduced inside the nasal chambers, and that, should such an event occur, the secretions of the parts tend to wash away the morbid matter before inoculation takes place. Secondary lesions of the nasal mucous membrane are analogous to, and often coincide with, those appearing upon the skin. They vary from a mere erythema of the nasal mucous membrane with increased secretion to intense hyperemia and DISEASES OF THE NOSE 97 swelling, with the presence of mucous patches or shallow ulcers, secreting a sanious and offensive mucopus. During the tertiary period nasal gummata are by no means rare. They appear as irregular nodulated swellings distending the mucous membrane of any part of the interior of the nose. A nasal gumma may be absorbed, leaving in some instances a characteristic stellate cicatricial contraction, or it may break down and produce an ulcer, before which the cartilages and even the bony structures of the nose may melt away like wax as the ulceration rapidly extends, thus producing in a marvelously short time the most hideous deformity. Exuberant granulations may spring from the ulcerating gumma and completely fill the nasal chamber or even project from the nares, simulating a malignant growth. When the ethmoid has thus been necrosed and exfoliated, there may remain, after the healing process is complete, but a thin fibrous membrane between the interior of the nose and the brain. The lateral wall of the nose may be destroyed entirely, so that the antrum of Highmore and the affected side of the nose become one large cavity. In other instances the septum, nasal processes of the superior maxillary, and the nasal bones may be partly destroyed in such a manner that the nose be- comes flattened upon the face, producing a most serious deform- ity. In aggravated cases the soft parts may also be involved in the process, until finally the anterior nares are represented merely by an irregular hole in the face. During the ulcerative process of a gumma the breath is generally very offensive. Hereditary syphilis pursues the same course as the tertiary form of the acquired disease. Treatment.-Constitutional treatment is of primary impor- tance. Prompt amelioration of symptoms follows the injection of salvarsan. When for any reason this remedy cannot be employed, mercury and iodid of potassium yield, at least in tertiary lesions, almost as satisfactory results and in most cases a course of mercurial treatment should follow the salvarsan injection or injections. The primary and secondary lesions are probably best treated by the internal administration of a pill 98 DISEASES OF THE NOSE, THROAT, AND EAR containing | gr. of the protoiodid of mercury (Formula 22). The patient may take from one to three of these pills three or four times a day, and, if necessary, a sufficient quantity of opium should be administered to prevent their producing diar- rhea. The pills are less likely to produce digestive derange- ments if taken after meals and at bedtime. Any ulceration upon the nasal mucous membrane should be touched every other day with the acid nitrate of mercury (1 to 4 parts of water) until they are healed; and the inflammation treated in the meanwhile as a case of simple chronic rhinitis. However, although the applications of acid nitrate of mercury are effectual in bringing about a rapid healing of the ulceration, they are somewhat pain- ful; and if the patient complains bitterly of the pain, a 12 per cent, solution of nitrate of silver should be substituted or the ulcerations merely may be dusted with powdered calomel. In tertiary syphilitic rhinitis the mixed treatment answers a very useful purpose, for, while the iodid of potassium is not a specific in syphilis in the sense that mercury is, yet it gives a much quicker result in controlling tertiary manifestations. One, two, or three teaspoonfuls of Formula 21 may be given three or four times a day, according to the emergencies of the case and the patient's susceptibility to mercury. Mercury may also at the same time be administered by inunctions, which are perhaps the most reliable and comfortable to the patient of any method of treating syphilis, as it rarely disturbs the digestion or causes ptyalism and can be used at any stage of the disease. How- ever, it stains the underclothing, and hence leads to the detection of the patient's condition by other members of the household. The patient prepares for a course of one week's inunctions by a preliminary hot bath and then each night rubs into the skin of the belly, chest, or back one dram of freshly prepared and scented mercurial ointment. The undershirt is not changed, but worn constantly during the week. At the end of this period the inunctions are either suspended for some days or weeks or continued at the discretion of the physician. Where the most speedy effect possible upon the syphilitic lesion is de- DISEASES OF THE NOSE 99 sired, mercury may be administered hypodermically. From 8 to 20 minims of Formula 24 should be injected into the cellular tissue of the back every other day or at less frequent intervals. If thrown into the cellular tissue of the back, a solution of corrosive sublimate not stronger than that of Formula 24 will not produce an abscess, but causes some pain. The first injection should be given deep into the cellular tissue beneath the skin under one shoulder-blade; the second injection beneath the skin of the other shoulder-blade; the third, 4 inches below the first; the fourth, 4 inches below the second, and so on down the back. But a few hypodermic injections arc ordinarily required to limit the spreading of a gummatous ulcer, which speedily assumes a more healthy appearance. In cases where gummata are so situated as to cause obstruction to nasal respiration, pain, and intense headaches from pressure, the action of medicines upon the growth are too slow and operative procedures must be resorted to. A gumma may be removed from a turbinated bone with the snare or scraped from the septum with a large nasal curette. Such operations, however, should not be performed upon patients of debilitated constitu- tions, or those who are not, or cannot quickly be brought under the influence of mercury, as otherwise the wound made by the operation will not heal and may result in extensive ulcera- tion. When a nasal gumma has broken down and is ulcerating, the parts should be kept scrupulously clean by the use of an alkaline solution (Formulas 1 to 5), and the wound stimulated to heal by the daily application of acid nitrate of mercury di- luted with 4 parts of water. Wounds resulting from operations upon gummata should be treated in the same way until the healing process is complete. Goundou, henpue, or dog nose is a proliferating periostitis beginning in the nasal processes. It usually follows and is probably identical with frambesia or yaws which is a tropical, contagious skin disease due to constitutional infection with a spirillum. The primary sore is usually extragenital. The secondary skin lesions from their resemblance to raspberries 100 DISEASES OF THE NOSE, THROAT, AND EAR give the name yaws to the disease. The lesions of the tertiary stage closely simulate those of syphilis but the Wassermann reaction is negative. It is most common and fatal in children. Adults seldom die from it. Treatment consists in the administration of iodid of potas- sium. Mercury is said to be useless. Nasal hyperosities may require removal by the chisel or rongeur forceps. Tubercular rhinitis is an inflammation of the interior of the nose characterized by the presence of tubercle bacilli. Etiology.-The disease is usually the result of the inoculation of the nasal mucous membrane by morbid material from an- other portion of the body of a tuberculous individual. Pathology.-'The most common lesion observed is a small ulceration, usually on the septum or floor of the nose. Occa- sionally hyperplastic nodules and papillomata, pale in color and either pedunculated or sessile, are observed. Symptoms.-'Crusts form upon the ulcerations and are blown from the nose. The ulceration may progress to perforation of the septum. The hyperplastic growths sometimes attain sufficient size to cause nasal obstruction. Diagnosis.-'The disease in its ulcerative form somewhat resembles syphilis; but as it rarely occurs except in individuals with advanced pulmonary tuberculosis, the diagnosis usually is easy. The surrounding mucous membrane is much paler than in syphilis; indeed, the whole mucous membrane of the nose is usually anemic. In doubtful cases, iodid of potassium exhibited for a few days in ro-gr. doses every three or four hours will usually decide as to whether syphilis is the cause of the ulceration. However, it should be remembered that tubercu- lous individuals frequently do badly under iodid of potash, and the "therapeutic test" should, therefore, be used with care to prevent irreparable damage. The Wassermann reaction, while only conclusive if positive, is preferable in advanced cases, and it is better in practically all cases when the diagnosis between syphilis and tuberculosis is doubtful to test for syphilis before resorting to the tuberculin test (see page 557). Papillomatous DISEASES OF THE NOSE 101 outgrowths examined microscopically show the presence of tubercle bacilli. Treatment.-The local treatment consists of cleanliness of the nasal cavities by the patient's use of an atomizer containing an alkaline wash, followed by spraying the nose with menthol- camphor-albolene. The physician may cleanse the ulcerations and touch them with solid nitrate of silver fused on the end of a probe (Fig. 41). Large papilloma may be snared, but it is advisable to do no unnecessary surgery in a tuberculous nose. As the disease rarely, if ever, occurs except in advanced pul- monary tuberculosis, the general treatment is more important than the local. Lupus.-The name lupus is applied somewhat loosely to various skin diseases: Lupus erythematosa, lupus congestiva, lupus superficialis, lupus sebaceus. Lupus erythematosa first appears as grouped red spots that ultimately coalesce into slightly raised patches. The initial lesion is always ery- thematous and, unlike lupus vulgaris, there is no tendency to- ward ulceration. Lupus vulgaris sometimes originates at the tip of the nose, either upon the mucous or, more often, on the skin surface. Etiology.-'The cause of the disease is tubercle bacilli. Pathology.-'The lesion manifests itself as reddish-brown nodules. These atrophy, leaving scars, or ulcerate, involving sometimes large areas of skin, mucous membrane, and carti- lage. A large portion of the tip of the nose and septum may be destroyed. The ulcer is often covered by a brownish scab; when this is removed the ulcer appears filled with a granular "applejelly''-like mass, which can be readily scraped away with a curette. Deep cicatrices and deformities result from the healing of the ulcer. It may cicatrize at one extremity, while the progress of the ulceration is active at the other. The dis- ease is uncommon in America. Diagnosis.-Lupus so much resembles syphilis that the diag- nosis usually has to be established by the Wassermann reac- 102 DISEASES OF THE NOSE, THROAT, AND EAR tion, or the exhibition of iodid of potassium. From epithe- lioma it is differentiated by the microscopic findings. Treatment consists in the daily application of the x-ray. Rhinoscleroma is a disease of the mucous membrane of the nose extremely rare in North America, but occurring in Brazil, Russia, Italy, and other countries. Etiology.-According to some authorities the disease is the result of the presence of a characteristic bacillus. Pathology.-The disease produces nodular hypertrophies on the nose and sometimes within the nose, pharynx, and larynx. Ulcers appear upon the mucous surfaces resembling the lesions of tertiary syphilis. The contraction of dense cicatrices some- times results in deformities. Symptoms.-There is little or no pain at any stage of the dis- ease. The growth inside the nose may interfere with nasal respiration, and when the mouth and pharynx are involved it may be impossible for the patient to swallow solids. Involve- ment of the larynx may be sufficient to interfere with respira- tion as the result of cicatricial contraction. Treatment.-As the disease has a tendency to recur, operative interference is inadvisable, except tracheotomy when necessary to prevent death from stenosis of the larynx. Lang recom- mends salicylic acid locally and in xo-gr. doses internally. Leprosy of the Nose.-'According to Sticker and others the nose in the earlier stages of leprosy is the site of lesions dis- charging leprous bacilli, and while the statement that the initial lesion is usually upon the nasal septum has not been proved by clinical observation, yet, as stated by Brinkerhoff and Moor, "When it is not practicable to make a complete physical examination of all individuals of a class suspected of leprosy the examination of the nasal septum and the bac- teriologic examination of the nasal secretions will prove of value by permitting the recognition of the most dangerous type of the disease, and is therefore worth while even if it does not reveal all cases of the disease in those who come under observation." DISEASES OF THE NOSE 103 The theory that the initial lesion is usually nasal is prob- .ably untenable. H. T. Hollman, one of the physicians in the Kalanpapa Leper Colony, Hawaiian Islands, states that in an early stage of the disease the symptoms are those of hyper- trophic rhinitis, the nasal chambers being sometimes completely occluded by the swollen turbinates. Sometimes small tubercles are present that degenerate into small-sized ulcers, which, however, heal nicely under appropriate local treatment. In neglected cases the symptoms do not differ from those of ordi- nary atrophic rhinitis: there is atrophy, foul-smelling accumu- lations, and loss of the sense of smell. Perforations involving in some cases nearly the entire septum are common. Indeed, the appearance of the interior of the nose not infrequently re- sembles that of neglected tertiary syphilis. Treatment.-Improvement invariably resulted in Hollman's cases from the use of a 25 per cent, spray of eucalyptus oil in albolene. In the atrophic cases discharge and odor dis- appeared after the use of eucalyptus spray and rubbing into the parts ichthyol (20 per cent.) in glycerin. Nasal Myiasis.-Occasionally the larvae or maggots of the ordinary house fly are found in the nose or ear of individuals with foul discharges. However, their presence is incidental, and not a cause of the disease. As the result of the deposit of the eggs of the screw-worm fly (Campsomyia macellaria) within the nasal chambers of man and the domestic animals, there results severe symptoms often terminating fatally. In America the screw-worm fly is found from the Argentine Re- public to Canada, but the greatest amount of damage is done in tropical and subtropical sections. A single fly is capable of depositing hundreds of eggs which hatch in less than twenty- hour hours. The worm or maggot reaches maturity in about a week, during which time its ravages in animal tissue are most destructive. It then instinctively abandons its unwilling host and buries itself in the earth during the puparial state, which occupies about fourteen days, and emerges a mature fly. Symptoms.-'The initial symptom is a peculiar sensation at 104 DISEASES OF THE NOSE, THROAT, AND EAR the base of the nose followed by inordinate sneezing and, finally, excruciating pain over the frontal sinuses and the maxillary antra, probably as a result of the penetration of maggots into these cavities. There is a temperature of about 1020 F. and in severe cases delirium may be present. Within a few days there is a foul-smelling discharge from the nose, which, however, does not contain maggots until, as already stated, after a week's sojourn in the tissues they instinctively seek the earth to undergo their transformation into mature flies. On inspection, the interior of the nose may present a necrotic or gangrenous appearance. The soft parts may be destroyed, exposing bone which may become necrosed. The palate is sometimes perforated and swallowing or speaking may be im- possible because of swelling or destruction of tissue; fetid odors then sometimes occur and pneumonia may result from in- spiration of septic discharges. Treatment.-'Pain is usually sufficient to require morphin. Chloroform is a specific to the extent that the maggots are either killed by its vapors or wriggle from the deeper tissues into a superficial position, whence they are readily removed. The inflamed tissue become remarkably tolerant to its local irritation and 25 per cent, in olive oil may be injected two or three times a day. Foreign Bodies in the Nose.-Children and insane persons occasionally insert into their noses buttons, cherry-stones, beads, beans, twigs, hair-pains, etc. Necrosed bones, when detached, act as foreign bodies and produce their character- istic symptoms. Rhinoliths, ascarides, and maggots are also found in the nose, and may be considered as foreign bodies. Symptoms.-Obstructed nasal respiration proportionate to the size of the foreign body. If the foreign body is large or causes pressure, headache and pain of a neuralgic character are complained of. At first the presence of a small foreign body in the nose of a child attracts but little attention unless the child tells its parent there is something in its nose. After a time a discharge of glairy mucus occurs, which excoriates the DISEASES OF THE NOSE 105 skin of the lips and alee, but the discharge soon becomes puru- lent and may be streaked with blood and be fetid. A one- sided discharge from a child's nose is almost pathognomonic of a foreign body, and under such circumstances the most care- ful and painstaking search should be undertaken to discover the offending particle. Rhinoliths generally contain as a nucleus a foreign body around which the nasal secretions accumulate and deposit a coating of earthy salts, gradually increasing in thickness. The presence of a rhinolith causes practically the same symptoms as that of a foreign body of similar size and shape. Treatment.-The foreign body or bodies should be removed by means of a pair of forceps or a blunt ear curette. Rhinoliths may sometimes be removed whole or may have to be broken up by means of a powerful pair of forceps in order to remove them from the nose. Neuroses of the Nose. Motor Neurosis.-'Twitching of the nose and eyelid is generally due to peripheral irritation of some branch of the facial nerve. It occasionally occurs as the re- sult of the application of the galvanocautery to an anterior hypertrophy. Paralysis of the dilatores nasi produces a collapse of the lat- eral walls of the anterior portion of the nose that decidedly in- terferes with nasal respiration. Unilateral paralysis of the dilator nasi occurring in childhood, according to some of the older writers, is one of the causes of deviation of the nasal septum. The partial stenosis in long thin noses, due to the valvular action of the anterior portion of the sides of the nose by which inspiration is impeded, can be entirely alleviated by cutting a strip of requisite length from a visiting card, bending it, and placing it with its ends up inside the vestibule of the nose in such a manner that it acts as a spring holding the ante- rior nares open. However, in such cases the valve-like action of the anterior portion of the sides of the nose disappears permanently in many instances by increasing the breathing 106 DISEASES OF THE NOSE, THROAT, AND EAR space by the removal of a small ecchondrosis from the septum or cauterization of the inferior turbinate. Sensory Neuroses.-Anosmia, or loss of the sense of smell, may be congenital or acquired. If acquired, the condition may be due to syphilis, hysteria, or result from lesions of the olfactory bulbs produced by meningitis, tabes, or the pressure of a brain tumor. Disturbances of the sense of smell amount- ing to almost complete loss occur from any cause that prevents odorous particles reaching the portions of the nose where the peripheral nerve-endings of the olfactory nerves are distributed. An ordinary cold, hypertrophic rhinitis, or polypi frequently cause mechanically greater or -less loss of the sense of smell, which returns after the mechanical obstruction is removed. In atrophic rhinitis affecting the vaults of the nasal chambers there is generally great impairment of the sense of smell, which in some cases is partly restored when crusts and accumulations no longer form. In inflammation of the ethmoid cells, espe- cially in those cases where the middle turbinates are sufficiently swollen to press on the septum, great impairment of the sense of smell is usually present. Hyperosmia is an increased sensibility of the olfactory ap- paratus. The ability to detect odors, generally stenches, is intensified. The condition is sometimes observed in nervous women. Parosmia is a perversion of the sense of smell associated with local or systemic disturbances, insanity, etc. The sensation of a bad odor is sometimes a part of the aura of epilepsy. Hyperesthesia and anesthesia of the nasal mucous membrane are occasionally encountered. Paresthesia, or the sensation of imaginary stenosis or foreign bodies in the nose, occurs in a certain proportion of neurotics. It is not an unusual thing for such patients to complain of stenosis when the condition present is atrophic rhinitis with widely patulous nasal chambers. Reflex nasal neuroses are classified according to Jurasz into: i, Those with the initial point of the reflex circuit within the DISEASES OF THE NOSE 107 nose; 2. those in which the initial and end points of the circuit are within the nose; and 3. those in which the end point only is within the nose. To the first class belong asthma, reflex cough, spasm of the pharynx and glottis, and rarely epilepsy, etc. To the second group belong hay fever, and nasal hydrorrhea. The third group consists of cases where there are nasal symp- toms or changes as the result of abnormalities of the genital tract. Examples are the violent fits of sneezing produced in some males by sexual excitement and congestion of the nasal mucous membranes in either sex during the period of court- ship, control of the pain of dysmenorrhea by applications of cocain to the so-called nasal genital spots of Fliess which are the tuberculum septe and the anterior portion of the inferior turbinate. These are spots of great susceptibility to irri- tants on the lateral wall of the nose above the anterior end of the middle turbinate and on the septum anterior to this locality. In asthmatics, touching one of these spots will sometimes bring on an attack which subsides when cocain is applied. Light cauterization is sometimes of value in the treatment of such cases. Hay-fever, or coryza vasomotoria periodica, is a chronic nasal affection depending upon disturbance of the nervous system, and particularly of the various nerves supplying the nasal mucous membranes, and characterized by periodic ex- acerbations caused by inhaling dust or other irritants. The synonyms-hay-asthma, autumnal catarrh, rose cold, horse cold, cow cold, peach cold, snow cold, miller's asthma- are names given to the affection and supposed to indicate the irritant which is the direct cause of the attack of the disease. Etiology.-'There are three factors in the causation of an attack of hay-fever, viz.: First, a pathologic condition of the nasal chambers; this may comprise anterior or posterior hyper- trophies, exostoses, ethmoiditis; but more especially the pres- ence of hypersensitive areas, distinguished by their heightened color and slight elevation above the surrounding mucous mem- brane. Irritation of one of these spots with the end of a probe 108 DISEASES OF THE NOSE, THROAT, AND EAR even during the winter time will bring on an attack of hay-fever lasting from an hour to several days; second, a diseased or, at least, an irritable condition of certain nerve-centers, giving rise to a train of near and remote symptoms by reflex action; third, the presence of an external irritant. The absence of any one of these factors is sufficient to prevent an attack. Symptoms of an attack of vasomotor coryza are those of coryza-a sense of dryness and itching in the nose, violent sneezing, occlusion of the nares, and profuse watery discharge. These symptoms are usually followed by conjunctivitis, lacri- mation, photophobia, headache-often of a neuralgic character -a hacking cough, asthma, and a general feeling of malaise. Treatment.-The most effective treatment of periodical hyperesthetic rhinitis is a sea-voyage lasting through the entire hay-fever season or residence in a region free from the presence of irritating pollens and dust, like that of the White Mountains of New Hampshire. (See Climatology.) For professional and business men, however, such a treat- ment involves hardships and loss of business opportunities that render it acceptable only as a last resort. Therefore any treatment that will enable the sufferer to remain at home in comparative comfort and attend to business is eagerly sought by the majority of workers suffering from hay-fever. The attention of the profession, chiefly through the writings of Seth Scott Bishop of Chicago, has been directed to the fact that the neurotic condition of the patient and the hypersensi- tiveness of the nasal passages were often due to an excess of uric acid in the blood, and that this excess could be eliminated by the ingestion of mineral acids. Probably any mineral acid would prove efficacious, but there are two which suggest themselves as peculiarly efficacious: hydrobromic acid, because of its sedative qualities, and nitro- muriatic acid, because it is thought to limit the production of uric acid. The writer's experience has been limited to the effects of nitromuriatic acid, which has been prescribed in doses of 5 to 10 DISEASES OF THE NOSE 109 drops of the freshly prepared concentrated acid after meals and sometimes also at bedtime. The dose should be diluted with a tumblerful of water, and the patient, after taking the medicine, should rinse out his mouth and swallow another half-tumberful of water. When effective, the results of the remedy are apparent within forty-eight hours, and the relief of all hay-fever symptoms is usually sufficient to enable the patient to remain at home and attend to his ordinary business engagements in comparative comfort. If, however, a single dose is omitted, some symp- toms of hay-fever will appear within a few hours. This is especially true if the remedy is not taken after the evening meal, as, under such circumstances, the patient usually wakes up the next morning with occluded nares and suffused eyes. Between the attacks of hay-fever measures should be adopted to improve the patient's general health and correct any abnor- mality of the interior of his nose. The practitioner, however, should not be too sanguine as to the beneficial results to be obtained by such measures, for it should be borne in mind that hay-fever not infrequently occurs in vigorous individuals the interior of whose noses present no gross abnormality except during the hay-fever season. There is, however, one condition of the nose that is appar- ently present in all individuals suffering from hay-fever, and that is the presence of hyperesthetic areas upon the respiratory portion of the nasal mucous membrane, which when touched with a probe cause sneezing and lacrimation. The hypersensitive condition of such areas may be destroyed one or two at a time, even during the hay-fever season, without adding to the discomfort of the patient by either palliative or radical methods. The palliative method consists of cocainizing the nose and touching the sensitive area with a io per cent, solution of chromic acid applied by means of a cotton-tipped probe. The radical method consists in destroying the sensitive area with the galvano-cautery. A small cautery-knife should be selected, 110 DISEASES OF THE NOSE, THROAT, AND EAR and the current should be sufficiently strong to instantly bring its tip to a white heat. After cocainizing the nose, the cautery- tip is moved over the mucous membrane until a sensitive area is discovered. The current is then turned on for an instant and the cautery-knife withdrawn. Very little destruction of the membrane results, and should hemorrhage occur, no undue haste should be used in controlling it, as the local depletion is beneficial rather than otherwise. Temporary relief may be obtained during the worst stages of the attack by spraying the nose with a weak alkaline i per cent, solution of cocain, and afterward with fluid vaselin as a pro- tective. It is, of course, justifiable to use cocain during an office treatment, but cocain should not be prescribed for the patient's home use, as hay-fever victims are often, because of the neurotic temperament, the class of people most liable to contract the cocain-habit. As a home treatment the patient may spray the nose every hour or two, if necessary, with a solution of adrenalin hydro- chlorate in the strength of i: 10,000 or 1:20,000. The solution should be freshly made and free from antiseptics, and for these reasons the drug is best prescribed for patients' use in the form of a small tablet which when dissolved in the proper amount of water forms a solution of the required strength. However, in many instances oily preparations are more efficient than watery solutions, and an ointment made up with lanolin and vaselin of a strength of 1:10,000 is of decided value. It is conveniently dispensed in collapsible tubes, so that the patient can carry it about in his pocket and squeeze out from the tube from time to time the amount of ointment required. A piece the size of a pea may be inserted into each side of the nose every two hours by a brush or simply with the tip of the little finger. The head is then thrown back until the ointment melts and distributes itself over the nasal mucous membrane. Adrenalin (1:1000) in oil may be applied by means of a nebulizer. This form of medication, because of the minute amount of adrenalin actually deposited in the nose, is most successful in the mild cases. DISEASES OF THE NOSE 111 After the attack has subsided, all pathologic conditions of the nose should be removed, and the sensitive areas cauterized with a small galvanocautery-knife. Professor Dunbar, of Hamburg, has prepared hay-fever antitoxin by the inoculation of horses with the toxins obtained from the albuminoid body found in the starch particles of pollen. The serum obtained from the horse is dispensed either in a liquid or dry form, and is designated to be applied to the mucous membranes of the nose and that of the eyes when required. The serum has been named Pollantin, and two forms are on the market, one prepared from rye pollen, especially used for spring and summer hay-fevers or "rose cold," and the other, prepared fron ragweed pollen, designed as a remedy for the hay-fever occurring in the late summer and fall. Dunbar believes that hay-fever is the result of a specific poison found in pollens, and his antitoxin is designed to immu- nize patients against pollen toxins when used previous to the hay-fever season, and also to palliate the symptoms in cases where the disease has already made its appearance. When applied to the inflamed mucous membrane of the nose or eye, pollantin produces a sensation of ease and comfort which persists for some time. There are a number of drugs which when taken internally are capable of at least mitigating the severity of the local symptoms of hay-fever. The more important are atropin, hyoscyamus, heroin, quinin, monobromate of camphor, and strychnin, and in cases where nitromuriatic acid fails to afford relief, a com- bination of two or more of these drugs may be prescribed (For- mulas 53-59). In cases where there is manifestly an excess of uric acid in the tissue, a course of salines (Formula 52) and restricted diet should be prescribed at least during the period immediately preceding the expected attack. Prognosis.-It is not unfavorable. Many cases completely recover. The patient should be kept under observation and DISEASES OF THE NOSE, THROAT, AND EAR 112 occasionally treated for at least three years after an apparent cure to prevent the danger of a relapse. Nasal hydrorrhea is a disease characterized by a clear watery discharge from one or both nostrils as the result of some irrita- tion or disturbance, either peripheral or central, of the vaso- motor supply of the nasal mucous membrane. Ecology.-In one class of cases the flow of fluid from the nose is perfectly passive and causes no inflammation. The phe- nomenon is probably due in such cases to a paresis of the nasal branches of the trifacial nerve, which exercises an inhibitory action upon the normal exosmosis of serum in the nasal mucous membrane. In a second class of cases the flow of serum is accompanied by great congestion and swelling of the Schneiderian membrane, and the phenomena are the result of an irritation of the vaso- motor nerves. In this second class of cases the congestion and inflammation of the nasal mucous membrane and the conse- quent watery discharge are greatly increased by cold and by inhaling dust and other irritants. Indeed, the symptoms are somewhat similar to those of hay-fever. Symptoms.-In the first class of cases there is an almost constant dropping of a clear watery fluid from one or both nos- trils. In the second class of cases the discharge is more remit- tent in character, according to the amount of irritation of the Schneiderian membrane. Treatment.-'Richard Lake claims that the blood is the source of trouble in many instances and successfully treated severa, cases with calcium chloride 35 to 45 grains a day for two weeks. The rhinorrhea was not only completely relieved but recurred, if at all, only at long intervals easily remediable by treatment. Disease of the ethmoid cells (page 181) sometimes produces rhinorrhea which ceases when the ethmoidal condition receives appropriate treatment. In some cases adrenalin acts as a specific. A solution of the strength of 1:20,000 up to 1:1000 should be sprayed upon the nasal mucous membrane sufficiently often to control the symptoms. From 2 to 5 gr. of the extract DISEASES OF THE NOSE 113 of suprarenal capsule also should be taken every three hours, the patient being instructed to cease taking the remedy should disagreeable heart symptoms manifest themselves. In some cases a cessation of the discharge occurs within a few days, and the use of the remedy should then be discontinued. Sometimes astringents applied locally answer a useful pur- pose, and an ointment of gallic acid (io gr. to the ounce of vase- lin with i or 2 gr. of menthol) may be prescribed with benefit. Cerebrospinal rhinorrhea is a discharge of cerebro-spinal fluid through the nose and should be carefully differentiated from nasal hydrorrhea which is simply a discharge from the nasal mucous membrane. The amount of cerebro-spinal fluid discharged in 24 hours may reach 12 to 16 ounces. The diagnosis of such cases rests upon an analysis of the fluid. Normal cerebro-spinal fluid is transparent and colorless and may deposit cells from the cerebro-spinal cavity. It is alkaline, with a faint reaction for sodium chlorid. Heat and nitric acid yield no deposit, but on cooling a slight white cloudi- ness indicates the presence of albumose. It usually reacts with an orange-red deposit to Fehling's test. The prognosis as to cessation of the discharge is not good, yet patients have lived for many years without fatal infection of the meninges, but about 75 per cent, of the cases reported suffered from optic neuritis, atrophy, or hemiopia. No treatment is effective, but headache, drowsiness and other cerebral symptoms improve when the flow is free. Occasionally the discharge ceased abruptly. Nasal Hemorrhage. Etiology.-It is an old saying that re- current hemorrhage from the nose may be a warning, a remedy, or a disease. The bleeding may be the result of some disease of the blood, of which the most common are plethora, purpura, hemophilia, and the condition of the blood brought about by typhoid and the eruptive fevers. Diseases of the blood-vessels, the result of atheroma or syphilis, are predisposing causes, while the in- creased blood-pressure resulting from Bright's disease and 114 DISEASES OF THE NOSE, THROAT, AND EAR organic disease of the liver, heart, lungs, or kidneys are fre- quently early manifested by bleeding from the nose. No good observer probably has failed to be impressed with the very evident correlation existing in most of our domestic animals between the nose and the sexual organs exhibited during the rutting season. Similar phenomena occasionally are observed in the human race, and many amusing stories are told in illustration. Erectile tissue occurs in but three portions of the human body: the nose and throat, the nipples, and the sexual organs. In the male, puberty is accompanied by a change of voice, and nosebleed is not uncommon at this time in either sex; in the female, sometimes as a vicarious menstruation. Recurrent nosebleed is said to be aggravated by masturbation. Ulcerations and neoplastic growths within the nose are some- times hemorrhagic. Angiomata, carcinomata, sarcomata, and especially fibromata frequently bleed at the slightest touch. Severe and repeated nasal hemorrhage, when .it occurs in a youth with a nasopharyngeal tumor, is almost diagnostic of fibroma. Traumatism is a frequent cause of hemorrhagia narium. If the blood flows from each side of the nose in equal amounts, it is somewhat suggestive of injury to the vault of the pharynx or even fracture of the base of the skull, because hemorrhage from injury to the nose alone is usually unilateral. However, blood from the nose may be swallowed or drawn into the bronchi and afterward coughed up or vomited in a manner suggestive of a pneumonic or stomachic origin of the hemorrhage. It is not always easy to make a diagnosis between bleeding from the vault of the pharynx and hemoptysis. The nasal vessels are not supported by a muscular cushion into which they may be crushed by a blow, but lie in more or less intimate contact with bone or cartilage, and are only pro- tected by extremely delicate mucous membrane, and hence a slight injury is sufficient to cause hemorrhage, which is profuse and long continued because the proximity of bone or cartilage DISEASES OF THE NOSE 115 prevents the ends of the severed vessels from contracting aS readily as if they were imbedded in soft tissue. When sawing exostoses from the septum an artery within the bone is occa- sionly encountered, and because the end of the vessel is held wide open by its attachments to the bone, hemorrhage is in- variably profuse and long continued. Such cases require rad- ical measures to control the flow. Fortunately, however, ar- teries within such growths are comparatively rare. Since the use of adrenalin solutions before nasal operations it is said that secondary hemorrhages after nasal operations are more com- mon. The usefulness of this drug has its limitations. Its ef- fects only penetrate a certain depth into the tissues and it, of course, has no effect on a vessel deeply imbedded in bone. The reaction after its use as a therapeutic agent to control conges- tion is much greater than that of cocain, and therefore, it must be used for this purpose only in dilute solutions. The prognosis of all forms of nasal hemorrhage is generally favorable, but few fatal cases having been reported. Pathology.-The great vascularity of the nasal mucous mem- brane readily explains the great frequency of nasal hemorrhage. In most cases of spontaneous origin the bleeding is from the neighborhood of the septal artery-i. e., from the anterior part of the septum. Wounds resulting from surgical operations upon this portion of the nose frequently bleed profusely, al- though an artery is sometimes observed to " spurt " in the wound of an operation done further back upon the septum, while spon- taneous bleeding may occur from posterior hypertrophies or adenoid vegetations. In such cases the blood flowing down- ward into the fauces is expectorated and is frequently mistaken for a hemorrhage from the lungs. Treatment.-If after an operation severe hemorrhage has oc- curred, and it is known from what spot the bleeding occurs, a small mass of absorbent cotton or "Bernays' sponge" (Fig. 49) should be placed within the nose over the bleeding vessel. Bleeding may occur from any portion of the nose, but it is most common from the anterior portions of the septum. In 116 DISEASES OF THE NOSE, THROAT, AND EAR cases of recurrent nosebleed, after an attack, a small clot, a yellow spot, or a varicose condition of the veins upon the sep- tum will mark the seat of the hemorrhage. Under such circum- stances the patient should be directed to apply daily, by means of a brush, an ointment of gallic acid (io gr. to an ounce of vase- lin), and to avoid violently blowing the nose. Should the vessels be very numerous and varicose, this treatment will hardly suffice, and it will be necessary to destroy the vessels by a touch of the galvanocautery or chromic acid. It is not well to apply the galvanocautery or chromic acid too vigorously, as the cartilage of the septum has not much vitality, and too vig- orous application of either caustic may result in perforation. Simply singe the mucous membrane lightly with the flat side of a small cautery-knife. A whitish spot upon the mucous mem- Fig. 49.-Simpson's intranasal tampon shaped from "Bernays' sponge" or compressed cotton. When inserted within the nose, the cotton rapidly absorbs moisture and swells to many times its original thickness, thus exerting sufficient lateral pressure to control nasal hemorrhage. In wide noses two or even three tampons may be inserted side by side, although this is seldom necessary to con- trol hemorrhage. If too large, the tampon may be cut into the required shape with scissors. Strips of Bernays' sponge about 3 inches long and 12, 14 or 16 M. M. wide are often more convenient than Simpson's tampons. brane and the disappearance of the outline of the vessel indi- cates that the burn will be effective. Occasionally recurrent nosebleed is the result of a small ul- ceration or erosion of the mucous membrane of the anterior portion of the septum, generally in a hollow caused by a slight deviation of the septum or a cartilaginous spur within the nose. Because of the hollow upon the septal wall, mucus dries until the bulk becomes sufficient to extend above the hollow into the air-current, when it is dislodged by violently blowing the nose or by sneezing. Under such circumstances a minute portion of mucous membrane is carried away with the inspissated mucous and hemorrhage occurs. Sometimes the hemorrhage occurs DISEASES OF THE NOSE 117 from dislodging such masses of mucus with the finger-nail. The patient should be cautioned against picking his nose, as under such circumstances the resulting ulceration becomes deeper, until finally it extends entirely through the septum and a perforation results. Generally the formation of crusts and scabs can be prevented by frequent applications of carbolized vaselin, but should this not suffice, the hollow in the septum must be eradicated by suitable operative procedure. The usually slight bleeding from anterior ulcerations, as it occurs from time to time, can be controlled by grasping the tip of the nose firmly between the thumb and finger, the insertion of a small piece of ice within the naris, by applying an ointment of adrenalin on absorbent cot- ton, or by inserting a Simpson's tampon which when saturated with blood swells to the original bulk of the cotton before it was compressed (Fig. 49). In most cases such remedies as adrenalin are useless, because the flow of blood prevents their coming into contact with the mucous membrane and exerting their effects; not is it possible, in most instances, to accurately locate the bleeding spot and apply pressure to its directly. Usually the patient is found bending over a bowl upon his lap or he may be resting upon the bed in such a position that his head leans over its side so as to allow the blood to drip into a receptacle upon the floor. Have him at once sit erect, with his head neither thrown back nor forward, and instruct him to hold a finger-bowl under his chin (not nose) to catch the flow of blood. This change of position takes off pressure from the veins in the neck and may be all that is necessary to stop the hemor- rhage. If this be the case, a little pledget of absorbent cotton, saturated with vaselin, should be inserted loosely within the naris to support the clot and prevent the patient breathing through that side of the nose. If in spite of the change of the patient's posture the blood should continue to flow, it will be necessary to apply pressure to the bleeding vessel. This is most expeditiously, painlessly, 118 DISEASES OF THE NOSE, THROAT, AND EAR and effectually accomplished by inserting a Simpson tampon into the nose, which usually controls the bleeding as soon as the cotton is saturated with blood. In cases where the bleeding spot is far back in the nose, it is better to insert a strip of Bernays' sponge (Fig. 49) | inch wide and about 2^ long through the inferior meatus into the nasopharynx, and cut off with stout scissors any redundant portion projecting from the anterior naris. Such a strip when saturated with blood will completely occlude both the posterior and anterior nares. When Bernays' sponge is not available the bleeding is readily controlled by adding hydrogen peroxid to the clot within the nose which causes an increase of many times its original bulk. Wrap a piece of absorbent cotton loosely about an Allen probe Fig. 50.-Method of making pressure-cone of cotton for the control of nasa hemorrhage. A piece of absorbent cotton (a) is frayed at each end into a thin edge, folded through the middle (dotted line a), and loosely wrapped about a nasal applicator in such a manner as to form a cone. This is dipped into hydrogen per- oxid and placed within the nose. so that it forms a cone 3 inches in length and 1 inch in diameter at its proximal extremity (Fig. 50) Thrust this dripping with hydrogen peroxid along the floor of the nose until the pharynx is reached. Place the forefinger-tip against the cotton within the nose and withdraw the probe, leaving the cotton in position supported by the finger-tip until the pressurecaused by he ebullition of gas has somewhat subsided, then withdraw the finger and support the first pledget by means of asecond plug of cotton saturated with hydrogen peroxid. This is pressed firmly into the naris, especial care being taken that it firmly fills the space within the extreme tip of the nose, or DISEASES OF THE NOSE 119 blood will escape over the cotton plug. If required, a third or even a fourth plug of cotton may be used. It is well to smear the whole of the presenting surface of the cotton with a solution of perchlorid of iron, which dries with a little blood into a black impenetrable varnish, and allows no blood to trickle. Never apply any of the iron salts inside the nose to control hemorrhage, as they are extremely irritating and form a sort of sticky black sand difficult to remove. This method of controlling nasal hemorrhage is much less irritating than most others employed; but at the end of five or six hours swelling of the mucous membrane will have occurred to a sufficient degree to render the packing within the nose somewhat uncomfortable, and it is generally advisable and safe to remove the outer plug. This should be done with extreme gentleness, avoiding any sudden pull or jerk. At the end of twelve or twenty-four hours the larger mass of cotton can often be removed with safety if done in a proper manner. Avoid removing pressure too suddenly or the hemorrhage will certainly recur and the packing will have to be replaced. It is well to have at hand a smaller cone of cotton saturated with peroxid to instantly replace that removed should this accident occur. Grasp the end of the mass of cotton to be removed with a pair of dressing-forceps and draw it forward | inch, then wait five minutes. Repeat this procedure at intervals of five minutes until the mass is coaxed, as it were, from the nose. If, during this process, a drop of blood shows itself, cut off with a pair of bandage-scissors that portion of the cotton already out- side of the nose and press into the vestibule a little mass of fresh cotton saturated with peroxid. Be content to wait for an hour or so before again trying to remove the packing; for, at any rate, you have diminished the pressure within the nose and rendered your patient more comfortable. If, however, you have succeeded in removing the whole of the cotton without the hemorrhage recurring, place a little cotton in the vestibule of the naris and allow your patient to rest for a half-hour or so before permitting him to blow out the clot--which should be 120 DISEASES OF THE NOSE, THROAT, AND EAR done with great gentleness. It is advisable in all cases to re- move the packing from the nose at the end of forty-eight hours, as by that time it will be extremely foul smelling and there is danger of sepsis. If necessary to check the recurrent hem- orrhage, the nose can be packed again with cotton saturated either with peroxid or alboline, which, next to peroxid, is probably the best hemostatic for use within the nose. In most works on surgery an instrument called Bellocq's cannula is figured, by means of which the posterior nares may be plugged by drawing a mass of gauze through the mouth behind the soft palate; if at hand, this instrument may be used. A simpler plan is to insert a Eustachian catheter through the nose and pass a catgut suture, string or well-waxed piece of stiff silk or linen suture through it until its end appears in the fauces, when it may be seized by a pair of forceps and drawn out through the mouth. A piece of iodoform gauze should then be tied to the middle of the catgut string or waxed cord, and drawn up behind the palate into the vault of the pharynx in such a manner that one end of the string projects from the nose and the other from the mouth. The ends of the suture material may now be tied together, so that the plug is firmly held in position. If a Eustachian catheter is not available, a silk suture may be tied around the eyelet of an ordinary soft- rubber urethral catheter, which is then passed through the inferior nasal chamber until the suture and catheter appear in the pharynx. However, plugging the posterior nares is seldom, if ever, necessary to check hemorrhage from the nose, but may be used where ether is administered to prevent blood flowing into the pharynx during an operation upon the interior of the nose. In hemophilia or purpura, after the nose has been packed with absorbent cotton and peroxid, calcium chlorid or lactate (Formula 47), 5 to 10 gr. every two hours, may be given in cap- sule or dissolved in a little water. However, human blood or horse serum by supplying "fibrin ferment" to the patient's blood sometimes quickly controls hemorrhage in these cases. From DISEASES OF THE NOSE 121 io to 30 c.c. should be injected subcutaneously. "Coagu- lose or desiccated serum disolved in normal salt solution may be used in the same manner as the fresh serum. TUMORS Nasal Polypus.-The most common growths to be found within the nose are mucous polypus, fibroma, or fibrous poly- pus, cyst, ecchondroma, exostosis, osteoma, papilloma, an- gioma, sarcoma, and carcinoma. Fibrous polypi differ from the soft or mucous polypi simply because of the proportion of fibrous material each contains. Instead of being soft, gelatinous, and highly hygrometric, fi- brous polypi are hard and fibrous. They usually have their attachment in the upper posterior portion of the nasal cham- bers but sometimes within the antrum. When attached to the junction of the nose and pharynx the fibrous tissue is so abun- Fig. 51.-A, Mucous polypi in the nose; B, anterior view of same, normal size (Sajous). dant that the resulting tumor is a true fibroma almost as hard as bone. Nasopharyngeal fibroma are extremely vascular, bleeding sometimes at the slightest touch. Fibrous polypi are probably local hypertrophies of the mucous membrane and sub- mucous tissues that have undergone fibrous change in pro- portion to the amount of connective tissue involved. Mucous polypi most frequently originate from the middle turbinated region of the nose. Here the mucous membrane 122 DISEASES OF THE NOSE, THROAT, AND EAR possesses low folds. It is thin, the subepithelial tissue loose and abundant, and the erectile tissues scanty. The mucous glands on the lateral surface of the middle turbinates are numerous. As the result of chronic inflammation from any cause the normal folds of the mucous membrane become edematous. This edema is favored by the dependent position of the parts until it is sufficient to develop into mucous polypi. The nor- mal active glands of the middle turbinated region prevent the occurrence of edema, but when the glands cease to act as the result of degenerative changes, edema results. Etiology.-Any long-continued irritation of the nasal mucous membrane may result in polypi. The most common causes are ethmoiditis or defective nasal drainage, as the result either of bony ridges on the septum, a deviated septum, or of hyper trophies of the lower turbinated bone. Treatment.-Removal of the nasal polypi and adequate treatment of the cause that produced them, in the manner described in the sections upon Ethmoiditis and Hypertrophic Rhinitis. The mere removal of the polypi is usually only the first step toward bringing about a cure of the nasal disease. Simple removal is usually followed by a relapse into the former condition. Therefore after the removal of the growth the surgeon should not be content until the parts from which they grew have firmly cicatrized. Operations.-The nasal chamber is cocainized with a pledget of cotton saturated with a 3 per cent, solution of cocain, and the parts sprayed with a 1 : 5000 solution of adrenalin. The operative speculum (Fig. 17) is then inserted into the nos- tril and the size and attachment of the most anterior of the polypi determined by a probe and by pulling it forward with forceps. The loop of a snare (Fig. 40) is then slipped over the polyp and manipulated until the loop encircles its base, the loop quickly tightened, and the polyp severed from its attach- ment by a little jerk. The parts are again sprayed with adrenalin and the next polyp removed by the snare, and so on until the nasal chamber is completely free from the growths. DISEASES OF THE NOSE 123 Spraying with adrenalin solution after the removal of each polyp usually prevents excessive hemorrhage and secures a satisfactory view of the middle turbinate region from which they grow. Should the inferior border of the turbinate be covered by stumps of polypi that have escaped the snare, it is better to remove this diseased tissue at once with a swivel- knife to prevent a return of the growths. There is no after-treatment except that the patient should cleanse the nasal chambers by spraying with Dobell's solution or some similar alkaline wash. The surgeon should inspect the surfaces from which polypi have been removed at sufficiently frequent intervals for about six months and remove small polypi (''buds") or any suspicious spot upon the middle tur- binate with a swivel-knife or punch forceps in order to secure a firm cicatrix. However, when instead of multiple polypi, the contents of a nasal chamber consists of a single large polypus, its removal is ordinarily followed by cure without further treatment. Nasal cyst usually occurs as a large sessile bladder, filled with a thin, watery, mucous fluid, attached to the inferior turbinated bone. N asopharyngeal fibromata consist of fibrous tissue containing numerous large blood-vessels which when severed bleed profusely because of the hardness of the tissue in which they are imbedded. These growths usually originate from the thick, fibrous aponeurosis covering the basilar process, but sometimes a pedicle extends from one of the accessory sinuses, especially the maxillary. They often hang down from the vault of the pharynx so as to be plainly visible through the mouth, and may send prolongations into the nose and all of the adjacent cavities, either bending around obstacles or eroding their way through them, enlarging the nasal chambers, thinning the bones, and broadening the bridge of the nose as they grow, causing great deformity or what is sometimes called "frog face." Such tumors cannot readily be removed by an ordinary snare. The best imported steel piano wire usually 124 DISEASES OF THE NOSE, THROAT, AND EAR snaps during the attempt, or the snare may be twisted into a cork-screw shape if an attempt is made to tighten the wire by turning the screw of the instrument with a wrench. The growth is, however, readily removed by means of a galvano- cautery snare with its red-hot wire. Relapses are common, although the disease generally attacks children; and there is a distinct tendency toward slower growth of the tumor or even retrograde changes as the individual advances in years. When the galvanocautery snare cannot be used, a pointed cautery-knife (Fig. 43) may be pushed through the tumor toward the center of the growth and heated while in situ. The current of electricity should be turned off as soon as the patient complains greatly of the heat and after an interval turned on again. This may be repeated several times before the cautery- knife is finally withdrawn from the growth, which should be done with gentleness and care while the current is turned on in order to avoid hemorrhage. The procedure is less painful than electrolysis and results in a greater amount of shrinking of the growth. Radical operations for the removal of nasopharyngeal fibro- mata with the knife have been successfully performed, but the fatalities have been somewhat numerous. Nasal papillomata are wart-like growths most frequently attached to the septum or inferior turbinated bodies. They are generally abundantly supplied with capillaries and some of them bleed at the slightest touch. Treatment.-They should be removed with the snare and the place of their implantation touched with the galvanocautery to prevent a recurrence. Nasal Sarcoma.-Sarcoma within the nose presents the same pathologic characteristics as when present elsewhere. It may occur as a primary growth or result from the degeneration of fibrous polypi or papillomata. Nasal sarcomata are generally sessile and of a light reddish color. In children they grow very rapidly and are prone to ulcerate, with the result of producing a fetid greenish or bloody discharge. Penetrating the surround- DISEASES OF THE NOSE 125 ing structures, great deformity of the face often results. If growths occur in an upward and backward direction, tinnitus, deafness, and severe pain are usually present, while death may occur from final involvement of the brain by the disease. Prognosis.-In children the growth ordinarily occurs so rap- idly that an early fatal issue is to be expected, while in adults a slower growth makes early and complete evulsion practic- able. The tumor will, however, return with increased malig- nancy if imperfectly removed. Nasal Carcinoma.-Carcinoma of the nose is of rare occur- rence as a primary affection, but may invade the nasal cavities from surrounding parts. It is usually of the epitheliomatous or encephaloid type. Treatment.-The varieties of sarcomata and carcinomata differ greatly in their malignancy. Nearly all recur after the most complete operation while apparent spontaneous cureshave been reported. The x-ray in many cases at least retards the progress of the disease and should always be employed after an operation before recurrence occurs. Even when the antrum is involved, the complete removal of the upper jaw is rarely necessary as access to the growth is readily obtained by the Jansen operation supplemented by an incision along the side and beneath the nose and through the center of the lip so that a greater exposure of the field of operation is obtained when the flap is dissected back. DISEASES OF THE NASAL SEPTUM Deviation.-Normally, the septum is vertical, but after the seventh year deviations generally toward the left are somewhat frequent. Such deviations from the vertical only are consid- ered pathologic when they interfere decidedly with nasal respiration or, by pressure upon the middle turbinated body, cause pain or disease. Etiology.-Traumatism is by far the most common cause of the pathologic deviations, the most frequent traumatism being 126 DISEASES OE THE NOSE, THROAT, AND EAR a dislocation of the triangular cartilage and the anterior por- tion of the vomer from each other and their attachment to the nasal crests of the superior maxillaries. Under such cir- cumstances the deviation is of the so-called angular variety, because the dislocated horizontal edge of the septum projects into the obstructed nares as a sharp edge or ridge running back as far as the dislocation extends. The dislocation rarely involves the whole septum, because the posterior portion of the septum is defended from the effects of traumatism by bony walls. Rarely is more than the anterior third of the septum involved in a deviation, and it is, therefore, more exact to speak of a deflected area of a septum rather than a deviated septum. Between the edges of the dislocated bones and cartilage "provisional callus" is thrown out, which finally unites the separated edges with a firm bony or cartilaginous union, usu- ally thicker than the normal septum, and hence the so-called "hypertrophied angle" of a septal deviation. It will be seen that after the organization of the "provisional callus" the sep- tum has notably increased in size, is redundant or too large to occupy a vertical position within the nose. According to the extent posteriorly of the dislocation of the septum from the superior maxillary may the deviation be described as vertical or horizontal. In comparatively rare cases a vertical deviation of the septum will involve so little of the septum anteroposteriorly as scarcely to admit the blunt end of a lead-pencil into the deflected area at the base of the septum. Such a deflection probably would result from a very rapid and violent bending of the tip of the nose to one side. Probably the larger number of deviations, so slight as not to be considered pathologic, are the result of a faulty develop- ment of the bones of the face. It is stated that adenoids and other causes of defective nasal respiration cause an arching of the palate, and the septum, crushed between this abnormally narrow arching of the palate and the nasal bones, is bowed, as it were, out of the median position. DISEASES OF THE NOSE 127 As a matter of fact, a comparatively large proportion of de- flected septa are encountered, associated with a narrow arch of the palate, and the deviation is due to incoordination in the development of the bones of the face, including those of the nose, and evidently not traumatic. Such deviations are curvi- linear instead of angular, sometimes S shaped, and there is usually little or no thickening of the sutural lines. However, they rarely, if ever, involve the whole septum. By artificially occluding one side of the nose of pupies and other young animals Ziem proved that under such circum- stances the occluded nostril and adjacent bones and accessory cavities remained undeveloped. Asymmetric development of the two sides of the face, if it involved the nasal septum, would result in the bowing or deviation of the septum toward the larger side of the face, be- cause the concave surface of a deviated septum is, of course, smaller than the convex surface. Pathology.-Septal deviations occur in almost endless variety. A simple classification is physiologic and pathologic, angular, with or without hypertrophied tissue at the angle, round and S shaped, vertical and horizontal. Symptoms.-There is sometimes some deformity of the external nose, the tip of the nose being turned to one side of the bridge flattened. The degree of obstruction in the narrowed nostril is in proportion to the deviation of the septum and may amount to occlusion. Usually in such cases there is complete obstruction to inspiration from a valve-like action of the ala of the affected side, while expiration is somewhat free as the re- sult of the blowing outward of the ala by the expired air. Nasopharyngeal catarrh is usually present and is the direct result of the deviation. It will be observed that during in- spiration a partial vacuum occurs posterior to the obstruction, and consequent vacuum congestion, that is, the decreased atmospheric pressure behind the obstruction engorges the blood-vessels of the mucous membrane by a species of suction. The vacuum congestion and consequent catarrhal inflammation 128 DISEASES OE THE NOSE, THROAT, AND EAR frequently extend backward to the nasopharynx. Vacuum congestion also occurs within the dilated portion of the un- obstructed nostril, and when chronic catarrh of the middle ear results, it is often the ear upon the side of the unobstructed nostril that first is affected. It might be objected to this me- chanical theory of the causation of vacuum congestion back of a deflected area upon the septum that any partial vacuum result- ing during inspiration would be counteracted by increased pressure during expiration. That this is not the case is due to the fact that expiration is more deliberate and passive than inspiration and the valve-like action of the ala referred to above. The amount of obstruction to nasal respiration resulting from a deflected septum is precisely the same as if the obstruc- tion resulted from an exostosis. When the obstruction is com- plete from inspiration the individual loses one-half his nasal breathing space; for what breathing space is lost in one nostril is not compensated for by increased breathing space in the other, because the unobstructed nostril is not larger, either anterior or posterior to the obstruction, and hence will not transmit more air than if the septum were not deflected. In the dilated area of the unobstructed nostril the inferior and sometimes the middle turbinated bodies are frequently hypertrophied, probably as the result of the increased blood supply resulting from the decreased atmospheric pressure in the dilated area referred to above. As the result of such hyper- trophy the breathing space within the dilated area may be reduced to normal limits. In the obstructed nostril the tur- binated body may become atrophied from the pressure of the deflected septum. Should the deflection be so located as to cause pressure upon the middle turbinated body, pain and nasal reflexes are usually present, and sometimes disease of the ethmoid and frontal sinus. Fortunately, great deviation of the septum in this region is comparatively rare, and if present without obstruction to respiration the removal of a portion of the middle turbinal will prove an easier and more satisfactory DISEASES OF THE NOSE 129 operation than an attempt to restore the septum to a vertical position by a submucous resection. In some cases when the deflection is slight as scarcely to be Considered pathologic, erosions occur upon the septum. The inspissated secretions of such erosions being in a hollow of the septum, and hence not in the direct breath-current, are usually removed by the finger-tip or by violently blowing the nose. Usually some of the septal tissue is removed w th the ac- cumulation and hemorrhage results. The condition is a com- mon cause of recurrent nasal hemorrhage. When such ac- cumulations are removed by the finger-nail the erosion usually becomes deeper and deeper, until the individual literally picks a hole through his septum. The two factors interfering with the success of operations for the correction of deviation of the nasal septum are redundancy and resiliency. The septum is too large to occupy a vertical posi- tion within the nose, and hence any operation, to be successful, must provide for the redundancy of the septum, both in the horizontal and vertical direction. The simplest method would seem to be a rectangular crucial incision through the center of the deviation. After such an incision, if the deviated area of the septum is brought into the median position, the edges of the four triangular flaps overlap, and thus the redundancy of the septum in both the horizontal and vertical directions is provided for. Redundancy of the septum is equally well provided for by multiple incisions through the septum, cross- ing each other at a common center, and by L, JL, U, and W incisions through the septum. This is far from being true as regards the resiliency of the septum. Septal resiliency of the deviated area is best counteracted by means of a long, narrow, quadrilateral flap but, of course, is completely de- stroyed by submucous complete removal of the cartilage and bone from the deviated area. It must not be supposed that because the deviated area of a septum is too large to be crowded into a position on a plane every point of which is equidistant from the lateral walls of the 130 DISEASES OF THE NOSE, THROAT, AND EAR nose .that, therefore, the tissues of the deviated septum are subjected to tension, which, if released, would result in the de- viated area of septum assuming a normal vertical position as the result of its resiliency. On the contrary, if a deviated sep- tum be dissected out from the nose, its deviated area does not change its shape, and if pressed into a position parallel to the rest of the septum, it immediately springs back into its original deflected position as soon as the pressure is released. It must not be imagined, as stated by some authors, that the resiliency of the sep- tum is destroyed by incisions of any shape, mentioned above, as the result- ing flaps when bent all tend to spring back into their former position. Resiliency is an inherent quality of both the bony and cartilaginous septum. However, if the bony por- tion be fractured, the broken bone re- mains in the position in which it is placed and the resiliency at the line of fracture is destroyed. The carti- lage of the septum, on the other hand, is not readily fractured, but when bent at a right angle or more, its resiliency is greatly lessened for a considerable time. Operations for Correction of Deviation of the Nasal Septum.-• Bosworth's Operation.-'The simplest operation is that intro- duced by Bosworth (Fig. 52)-'the removal of the hyper- trophied angle of the deviation with a saw. The operation is successful to the extent that it secures increased breathing space in the obstructed nostril. Gleason's Operation.-The writer's method of operating for deflection of nasal septum is as follows: A U-shaped incision (Fig. 53) is made around the deviated area (a), which then becomes a quadrilateral flap, covering a hole in the septum; a sort of trap-door with a spring hinge holding it in a deviated position. This quadrilateral flap is then, with the finger-tip, Fig. 52.-Vertical, trans- verse section through the an- terior portion of the nose; an- gular deviation of the septum, with hypertrophy of the tissues at the angle of the deviation. The dotted line indicates the direction of the saw-cut for the removal of the obstruction. DISEASES OF THE NOSE 131 pushed through the hole in the septum which it covers, and its neck (c) is bent at the same time at a right angle. The success of the operation depends almost entirely on a thorough bending of the flap. If the deviated area is of the horizontal type and extends far back along the septum the neck of the quadrilateral flap will contain a considerable amount of bone. When the neck of the flap is bent at a right angle this bone will be fractured with a snap, often audible at a considerable dis- tance. The resiliency of the bony portion of the flap is then as completely destroyed as if a submucous resection had been performed because fractured bone remains in the position in which it is placed. As a matter of fact it, to a certain extent, acts as a splint to retain the cartilaginous portion in a vertical plane, as it is impossible to fracture it even by bending to a right angle. However, by the thorough bending of the cartilage the re- siliency of the flap is diminished, for the time being, to the ex- tent that it hangs without support in the vertical position, its redundant edge overlapping, without pressure, the edge of the hole in the septum, in front, below, and behind. The quadrilateral shape of the flap has much to do with its remaining in a vertical plane. In any cartilaginous septal flap the resiliency tending to reproduce the original deformity is proportionate to the width of the base (c) of the flap. In the triangular flaps used by Asch, Roberts, Watson, and others the width of the base of the flap rapidly increases with the size of the flap. In the quadrilateral flap the base of the flap (Fig. 53, c) is always of. the same width as its edge (b), and conse- quently, because of constantly increasing leverage proportion- ate to the length of the flap, in long, narrow, cartilaginous flaps, but very little support at its lower edge (b) is required to main- tain such a flap in the vertical plane. This very important factor in the success of operations for the correction of septal deflections may be demonstrated by cutting flaps of various shapes in the side of a rubber ball, the resiliency of which may be compared to that of the cartilaginous septum. The main idea DISEASES OF THE NOSE, THROAT, AND EAR 132 in devising this operation was to provide a better method of overcoming the resiliency of the septum than those then in vogue, and all other considerations were sacrificed to this idea. In most operations it is not septal redundancy, but the neglect or the impossibility of providing for septal resiliency that causes failure. The resiliency of the septum is exerted for months upon septal flaps after apparent healing, and often gradually reproduces, in part at least, the original deviation. It is Fig. 53.-Diagram of author's operation. The traumatism originally caus- ing the deflection is practically reproduced by converting the deflected area of the septum into a quadrilateral flap: a, Deviated area of the septum, surrounded by a U-shaped incision; c, neck or base of the resulting quadrilateral flap; b, its in- ferior edge. impossible to judge of the success of an operation for septal deviation until at least six months have elapsed. Therefore it is best in most instances to slightly overcorrect the deviation. The technic of the writer's operation is as follows: Both sides of the septum are anesthetized by packing the nose with pledgets of absorbent cotton saturated with a 3 to 4 per cent, solution of cocain. This is allowed to remain in contact with the parts for one-half hour in order that the weak solution of cocain may penetrate deeply into the tissues. The nostrils are DISEASES OF THE NOSE 133 sprayed with a 1 : 1000 solution of adrenalin. The line of incision is then rubbed by means of a cotton-tipped probe with a saturated solution of cocain in order to produce profound su- perficial anesthesia. The field of operation is brought into view by means of the self-retaining speculum (Fig. 17), and a straight Sajous saw is introduced into the obstructed nostril, close to and parallel to the floor of the nose. The septum is sawed transversely until the saw has obtained a firm hold upon the tissues; the direction of the sawing is then somewhat rapidly changed until it becomes nearly vertical, the saw meanwhile being carefully maintained in a posi tionexactly parallel to the septum. A gush of blood from the unobstructed nostril indicates that the sawing has extended through the septum. The saw is now partly withdrawn and its tip pushed through the cut into the unobstructed nostril. The anterior crus of the U-shaped Fig. 54.-Seiler's septum knife. incision is made by sawing upward with the tip of the saw or a probe-pointed tenotome may be used for the purpose. The posterior crus is most quickly made by introducing a probe- pointed, double-edged knife, curved on the flat (Fig. 54), from the left nostril through the saw-cut. The index finger- tip is then introduced into the right nostril. Finger and knife together reach the posterior limit of the deviated area, and the posterior crus of the U-shaped incision is quickly and easily made. If the deviation is toward the right nostril, the operator wets his left forefinger in sterile water, while, if the deviation is toward the patient's left nostril, the right forefinger, after being wetted, is introduced into the obstructed nostril, pushing and, if necessary, lifting up the deflected area until it has been thrust through the hole in the septum which it covers. The operator's 134 DISEASES OF THE NOSE, THROAT, AND EAR forefinger-tip is then carried up along the anterior and posterior crura of the U-shaped incision to make sure that the flap has completely cleared them; the finger-tip is then thrust through the hole in the septum beneath the quadrilateral flap until the lateral wall of the nose in the unobstructed nares is touched. The finger is then pressed upward until the flap is bent at a right angle and any bone in the neck (Fig. 53, c) of the flap breaks with an audible snap. This is of the utmost importance, and in horizontal deflections the success of the operation depends entirely upon the bending of the flap being thoroughly done. Fig. 55. Fig. 56. Pigs. 55 and 56 show the overlapping which occurs in the Sajous, Roberts, Seiler, Gleason, and Watson operations after the upper or movable portion of the septum is pushed into the median line-a feeble and unreliable amount of support is given by this overlap-insufficient in most instances to prevent the reproduction of the deformity. In the Gleason operation success depends on three factors-the quadrilateral shape of the flap; that there is only one flap to bend, and a bending of this one flap so thoroughly as to completely destroy its resiliency. At the beginning both operator and patient are seated; but to more thoroughly bend and kneed the neck of the flap, the operator rises and places his disengaged hand on the patient's head. In vertical deflections too narrow to permit of the forefinger being used, the little finger should be employed. After the thorough bending of the flap it should hang in the formerly unobstructed naris without resiliency (Fig. 56); and either Allen's tube or the writer's modification of the same should be dropped into the formerly obstructed nostril. Should any impediment to its free entrance into the nostril be encount- ered, it is probable that the U-shaped incision has been im- properly made and has passed through instead of around some DISEASES OF THE NOSE 135 portion of the deviated area. This is usually the posterior portion of the deflected area, the posterior crus of the U-shaped incision being made too far forward. An effort should be made to bring this deflected posterior edge of the incision into line with the finger-tip in order to admit of the easy introduction of the tube, and, failing in this, the end of the tube should be compressed by the fingers in such a manner as to permit of its easily being passed beyond the obstruction. The tube should always fit loosely. Any great amount of pressure exerted by the tube becomes well-nigh intolerable within twenty-four hours. The tube serves to control the usually trifling hemor- rhage. It is worn over night and the next day it is decided if its support is longer necessary. In rather more than 80 Fig. 57.--Gleason's nasal tubes, made of soft malleable metal (pewter)._ These tubes may be readily cut with a pen knife to any desired length, and their shape considerably altered by bending and burnishing the edges. per cent, of cases of deviation of the nasal septum operated upon by the method described above no support whatever was necessary. The after-treatment consists in the patient presenting him- self at the surgeon's office daily, in the meantime attending to his usual avocation if not too laborious. At each daily visit the parts are inspected and, if necessary, cleansed. At first the overlapping of the edges of the flaps resulting from its redundancy will appear excessive because of the swelling. Within a week or two this swelling will have disappeared and also, apparently, much of the redundancy, because in traumatic cases the redundancy is newly formed tissue, "provisional callus," and hence is usually absorbed. At any time any redundant thickening can readily be removed, but 136 DISEASES OF THE NOSE, THROAT, AND EAR unless the obstruction is so large in the formerly unobstructed nostril as to produce a decided impediment to respiration it is best to defer "trimming up" the redundant septal thickening until several months have elapsed after the operation. Modifications. -In large horizontal deviations in large prom- inent noses the major portion of the flap will be cartilaginous, and the incision, instead of being U shaped, as in narrow verti- cal deviations described above, will be | | shaped. In such flaps the most thorough bending is not always sufficient to destroy its resiliency, and the operator has the misfortune to find the deviation reproduced within a few days after the tube is discarded. Ballenger has modified the author's operation by curving the upper ends of the U-shaped incision toward each other, thus C-> , so as to narrow the neck of the flap and decrease its resiliency. The same result can be accomplished by inserting a blunt-pointed tenotome beneath the perichon- drium and incising the neck of the flap. This can be done a week or more after the operation, when perhaps for the first time it is discovered that the deviation, at least at its anterior portion, is likely to be reproduced; or the operator can wait a month or more until healing is complete and then do a partial submucous resection, which is then comparatively easy, be- cause the bone at the lower border of the flap will be found un- united with that below. Fortunately, cases requiring second- ary operations are rare. Very infrequently horizontalCX) -shaped deviations are en- countered, where one nostril is occluded by the anterior devia- tion and the other by the deviation further back. In a case of this kind operated on by the author a successful result was secured by correcting the anterior deviation by the author's method and then bringing the posterior deviation into the median line with Adams' forceps and the forefinger. A modification of the author's method to the extent that quadrilateral flaps are used is the K incision through the devi- ated area, described by Price and Brown. Such quadri- lateral flaps, of course, have the abvantages already described DISEASES OF THE NOSE 137 over the triangular flaps of Asch, Watson, and others; but, theoretically at least, two quadrilateral flaps are inferior to one for overcoming the resiliency of the deviated area. However, it has often occurred to the author that in some horizontal deviations it would be an advantage to point his U-shaped in- cision forward instead of downward, because bone would then be encountered at the neck of the flap, which, when broken, would completely destroy the resiliency of the flap. Kyle's Operation.-Kyle, of Philadelphia, makes horizontal parallel incisions through the deflected area on opposite sides of Fig. 58.-Fetterolf's sharp-edged triangular file. the septum by means of Fetterolf's triangular file (Fig. 58), and brings the enclosed area into the median line by means of fin- ger or forceps. The operator's finger is inserted into the unob- structed nostril and a parallel incision is made with the sharp- edged file (Fig. 58) at the apex of the convex surface of the septum, the finger of the operator readily detecting when the cartilage has been cut through to the mucous membrane. If desirable, more cartilage can be removed by means of a file truncated on its edge (Fig.59), in order to avoid wounding Fig. 59--Fetterolf's truncate-edged triangular file. the mucous membrane of the convex side of the septum. Through the concave side of the septum two parallel incisions are made with the file; one above and the other below that from the convex surface. These incisions do not involve the mucous membrane of the convex surface. The deviated area is practically bounded above and below by these later inci- sions. Its resiliency is destroyed in the vertical direction and redundancy disappears as the result of the removal of the tri- angular strips with the file. The deviated area is now pushed 138 DISEASES OF THE NOSE, THROAT, AND EAR into the median line with the finger-tip and manipulated in such a manner as to destroy its resiliency. A tube (Fig. 57) is inserted into the formerly obstructed naris and the after- treatment is similar to other operations for deviations of the nasal septum. In submucous resection, the cartilage and bone of the entire deviated area is removed, the mucoperiosteum of both sides of the septum being preserved. An incision is made within the left nostril at the junction of the skin and mucous membrane extending from a point high up upon the septum downward well into the floor of the Fig. 6o.-Ballenger's septum knife. nose. Freer in certain cases also makes an incision extending backward from the vertical incision. It is better in most instances to carry the primary incision at once transversely through the cartilage to the mucoperiosteum of the right side in such a manner that the membrane is lifted on the knife point without being cut; the depth of the incision being directed Fig. 61.-Freer's septum knife by a finger tip inserted into the patient's right nostril. The posterior cut edge of cartilage is now bent into the left nostril where the lines of union between it and the mucoperiosteum of each side are plainly in view. The perichondrium is sepa- rated without difficulty on the right side by simply thrusting the dull end of Ballenger's elevator (Fig. 62) between it and the cartilage and sweeping the instrument downward. On the left side the periosteum is elevated with greater difficulty, for at first the point of the elevator (Figs. 62, 63) used as a curette is usually required to start the separation sufficiently to permit the introduction of elevator (Fig. 62 or 63). This is DISEASES OF THE NOSE 139 thrust between the cartilage and the perichondrium in the direc- tion of least resistance, which is usually upward and backward from the upper angle of the wound where the perichondrium is less firmly attached to the cartilage. The perichondrium is separated by sweeping the instrument downward. It is not necessary to rotate the instrument on its long axis and the dull end of the instrument (Fig. 62) is better for this part of the work. If there is any great difficulty experi- enced in denuding the cartilage it is prob- ably because the operator is inadvertently trying to separate the mucous membrane from the perichondrium, a matter of con- siderable difficulty, -and this mistake should be corrected. When the angle of the deviation is very sharp, the separation of the perichondrium from the cartilage in this locality is facili- tated by pushing the cartilage into the median line with the Ballenger instrument or a finger tip or it is sometimes helpful to grasp the portion of septal cartilage already denuded between long broad-jawed forceps and straighten such localities by closing them. The mucoperiosteum is then lifted up and separated on both sides of the septum at once by partly opening the forceps. The triangular cartilage is completely surrounded by its own perichondrium, which should be remembered when denud- ing at sutural lines where it is necessary to cut with a sharp knife the perichondrium extending through the suture. Fig. 62.-Ballenger's double elevator: a, Semi- sharp end; b, dull end. 140 DISEASES OF THE NOSE, THROAT, AND EAR If it is found impossible to denude the septum without making large tears in the mucous membrane, the operator should abandon the attempt and do a Gleason operation. The septal cartilage being now cleared on both sides, and its perichondrium held out of the way with a long-bladed speculum (Fig. 64), is readily removed in one large piece by the Fig. 63.-Freer's sharp and blunt elevators. swivel knife (Fig. 65). Up to this point the operation has been nearly painless and should not occupy more than five or ten minutes. However, when there is an additional bony deform- ity, that portion of the perpendicular plate involved should be cut away with septal bone-clipping forceps. The attachment of the vomer to the anterior nasal spine is now cut through with a chisel or clipped with for- ceps. Adams' forceps (Fig. 67) is now applied, with one blade in each nostril, and the anterior por- tion of the vomer grasped through the mucous membrane, and by a turn of the wrist cracked from its inferior attachment, when it can be removed readily with dressing forceps, leaving the mucous mem- brane untorn. No after-treatment is ordinarily required, except a Simpson's intranasal tampon, Fig. 49, worn in each nostril over night to hold the two raw surfaces of mucoperiosteum together and prevent the accumulation of blood between them. As the resiliency is certainly and completely destroyed by the removal of the septal cartilage and bone, this operation Fig. 64.-Foster's speculum. DISEASES OF THE NOSE 141 should yield, when successful, absolutely perfect results. The objections to it are its difficulties: The length of time frequently re- quired to perform it, the danger of septal perforations, and occasionally flattening of the tip of the nose. Therefore, it would seem that an operation requiring less time would be often preferable, except where the deviation extends sufficiently high upon the septum to involve the re- gions opposite the middle turbinates. This is especially true in the case of children; because a submucous resec- tion interferes with the future devel- opment of the nose, in most cases of atrophic rhinitis, in cases operated under ether, and in cases where be- cause of collapse of the patient or excessive hemorrhage it is necessary to finish the operation quick. The Gleason operation can always be done in less than 2 minutes and because the resulting scar is entirely outside the deviated area, does not interfere with a subsequent submucous resection should it prove unsuccessful. Congenital Occlusion of the Nares. -Congenital occlusion of either the anterior or posterior nares, usually unilateral, is a somewhat rare con- dition. When the posterior nares are occluded, generally it is the result of a bony outgrowth from the floor of the nose. The anterior naris may Fig. 65.-Ballenger's swivel knife. There are several sizes of this instrument. It is conve- nient for the removal of the sep- tal cartilage and many other pur- poses because its movable blade may be made to cut either up- ward or downward, backward or forward. 142 DISEASES OF THE NOSE, THROAT, AND EAR be occluded as the result of faulty development or adhesions during embryonic life. Symptoms.-The symptoms are those of occlusion from any other cause. When the occlusion is posterior, there is a dis- charge of mucus from the nose upon the lip and the patient is unable to cleanse the nostril by blowing the nose. Aural symptoms are sometimes present when the obstruction is anterior. Diagnosis is made by inspection. Anterior obstructions are readily seen, and those which are posterior may be observed in the rhinoscopic mirror. A rough estimate of the thickness of a posterior obstruction can be made with an Allen's probe, the end of which is wrapped with cotton and saturated with a 4 per cent, solution of cocain. This is introduced into the obstructed naris until the obstruction is reached, and the distance com- pared with that to the posterior edge of the septum on the un- obstructed side. Anterior obstructions are usually thin and web-like. Pos- terior obstructions usually have a thickness of not over | inch. Treatment.-It is comparatively easy to break down nasal obstructions, either anteriorly or posteriorly; but as they almost invariably recur unless prevented from doing so by a somewhat tedious after-treatment, the wisdom of operating in young children unless very docile is worth considering. When only one side is affected and causes but little inconvenience, the operation in young children should be postponed until the child has arrived at an age to appreciate the advantage to be derived from the after-treatment. Anterior obstructions are excised with a knife or scissors and a pewter tube (Fig. 57) of suitable size and shape inserted. This is removed and cleansed daily after the operation until the parts have completely cicatrized. Posterior bony obstruction are removed with the guarded electric drill or burr (Fig. 47), either under ether or, as the opera- tion is not very painful, under cocain anesthesia. If ether is employed, the tip of the forefinger of the operator's left hand is DISEASES OF THE NOSE 143 inserted into the posterior naris from the pharynx, to serve as a guide to the parts to be removed by the drill and to prevent injury to the surrounding structures. The after-treatment consists in daily cleansing the parts and the passage of bougies until cicatrization is complete. How- ever, in spite of every precaution, the posterior naris at the site of the operation frequently becomes again occluded by a thin cicatricial membrane. Should such a membrane form, it pos- sesses but little vitality, and in 2 cases observed by the writer was destroyed by piercing it in two or three places with a small galvanocautery-knife, after which it did not recur. Dislocation of the Columnar Cartilage.-The so-called colum- nar cartilage is the inner plate of the lower lateral cartilage of the nose (Fig. 36), a small strip of car- tilage lying parallel with the lower border of the septum, the purpose of which is to act as a support tc the columna. Dislocation of the columnar car- tilage, as ordinarily seen, consists of the displacement laterally of the distal extremity of the septum in such a manner as nearly to occlude the affected nostril (Fig. 66). Treatment.-The mucous membrane should be incised over the most prominent part of the deformity and the perichon- drium elevated in such a manner as to allow the excision of a sufficient amount of the septal cartilage to restore the patency of the affected nostril. It is not generally necessary to suture the edges of the incision after the excision of the cartilage. No after-treatment is required. Hematoma of the septum is an extravasation of blood be- neath the mucous membrane of the septum, generally the result Fig. 66.-Dislocation of the columnar cartilage of the nose into the right nostril (Bosworth). 144 DISEASES OF THE NOSE, THROAT, AND EAR of traumatism. It presents itself as a blood-red tumor, some- times large enough to obstruct nasal respiration. Prognosis.-The blood may be absorbed, or inflammation may occur and an abscess result. Treatment.-If the amount of blood is large, an incision should be made to allow it to escape. Should hematoma follow a submucous resection the wound should be reopened and the clot pressed out. Abscess of the Septum.-Etiology.-Abscess of the septum may result from traumatism, syphilis, or phlegmonous inflam- mation of the septum. Symptoms.-There may be the history of a chill, followed by fever, as in abscess elsewhere. Upon inspection the nose is found to be obstructed by a soft, fluctuating tumor of the sep- tum. Generally the cartilage is soon perforated, so that the tumor becomes bilateral. Treatment.-Early evacuation of the pus, to prevent exten- sive destruction of the parts involved in the inflammation and hasten resolution. The incision through the abscess should be sufficiently free to allow of syringing with sublimate solution if deemed necessary, and the patency of the opening should be maintained by the daily passage of a probe or the introduction of a drain of a few strands of chromatized gut or horse-hair. If a sequestrum of cartilage or bone form, it should not be re- moved until completely separated, and extreme care should be exercised to prevent injuring the mucous membrane of both sides of the septum, or a perforation of the septum will be present when the healing process is complete. Septal perforations occur from traumatism or follow the re- moval of an exostosis or other septal operation. Extensive destruction of the septum sometimes results from tertiary syphilis, or a perforation may result at the anterior portion of the septal cartilage from simple ulceration. Symptoms.-Posterior perforations present no symptoms. Anterior perforations of oblong shape sometimes cause whist- ling respiration, which disappears either wholly or in part if the DISEASES OF THE NOSE 145 perforation is made round. In this locality the edges of the perforation are not infrequently covered with crusts which cause slight hemorrhages when removed. Treatment.-Posterior perforations are best left alone. Gold- stein has pointed out that crusts only occur at portions of the perforation covered by cicatrice, and that if the mucous mem- brane is dissected back on both sides from the edge of the per- foration and a portion of cartilage removed with a swivel knife, so that after healing the edge of the perforation is covered by normal mucous membrane, crusts cease to occur. For this reason crusts do not occur in perforations following submucous resections. In fact even large perforations cause apparently no inconvenience and the patient's condition is infinitely better than if no operation had been done. Burton Haseltine has devised an operation in which a flap of mucous membrane is pulled forward over the aperture on one side and a similar flap pulled back on the other, thereby providing an intact membrane opposite each seam. The few stitches that are inserted must not produce tension. Submucous infiltration of the septum is a comparatively frequent accompaniment of chronic rhinitis, consisting of an edematous tumefaction situated on each side of the septum, generally at its posterior portion. Treatment.-If nasal respiration is obstructed, the masses may be scraped from the septum with the nasal curette or cau- terized with the galvanocautery. Injuries and Deformities of the Bony Framework of the Nose.-By far the most common result of nasal traumatism is dislocation of a portion of the septum from its attachment to the nasal processes of the superior maxillary bones. The dislo- cation is often overlooked at the time the injury is received because of the profuse hemorrhage. If a surgeon is consulted, his efforts usually are directed to controlling the flow of blood; and often he does not again see his patient for some days or weeks. Then the patient states that he can breathe only through one nostril. 146 plSEASES OF THE NOSE, THROAT, AND EAR Inspection of the nasal cavities shows a bulging area of sep- tum in the obstructed nostril corresponding to a concavity upon the septum in the opposite nostril. If seen within a week or two of the injury, the parts should be cocainized. The sur- geon then wets with sterile water the forefinger of his right hand if the patient's left nostril is obstructed, or the left fore- Fig. 67.-Adams' septum forceps. finger if the obstruction is in the patient's right nostril. With the palmar surface toward the septum and a slight boring motion the surgeon's finger is guided along the floor of the patient's nose. As the finger advances, pressure from the fin- ger-tip readily forces the dislocated septum into a position median to both sides of the nose, after which the tube (Fig. 57) is inserted to act as a splint. Flattening of the Bridge of the Nose or Saddle-back Nose.-A common result of nasal traumatism is fracture of the nasal bones at the root of the nose. The distal fragments are rotated outward on their long axes and depressed, producing a broaden- ing and flattening of the bridge of the nose. When only one nasal bone is fractured, the tip of the nose is usually turned to one side as the result of dislocation of both lateral upper shield cartilages and the septum. If the case is seen soon after the injury the displaced nasal bones are brought into position one after the other by means of Adams' forceps (Fig. 67), one blade of which is inserted into the nostril, so that the nasal bone can be grasped between the blades and lifted and turned into the normal position. When Fig. 68.-Carter's bridge and intranasal splint. DISEASES OF THE NOSE 147 both nasal bones are in place they are supported by a splint fashioned from gauze and collodion placed on the outside of the nose, or the nasal splint devised by Dr. W. W. Carter, of New York, may be used (Fig. 68). The instrument is held in place by two sutures passed from within out through the bridge of the nose. If the septum is deviated at the time of the injury it is brought into the median line and the tube (Fig. 57) inserted into the formerly obstructed nostril. Paraffin Prothesis.-When the bones of the bridge of the nose are destroyed or greatly distorted as the result of syphilis or other cause, satisfactory results follow the injection of paraf- fin beneath the skin into the cellular tissue of the nose. A special paraffin is prepared by mixing with ordinary paraffin white vaselin until the mixture melts at about 1 io° F. (Formula Fig. 69.-Harmon Smith's screw-syringe for the subcutaneous injection of paraffin. 85). This special paraffin is readily injected at ordinary tem- peratures through a needle but little larger than an ordinary hypodermic needle by means of the screw-syringe (Fig. 69). As the screw is turned the paraffin exudes from the end of the needle in a worm-like thread, readily compressible between the thumb and finger. The paraffin, having been melted, is drawn into the barrel of the syringe, which it completely fills. The end of the syringe where the needle is screwed on is then closed with a screw-cap to prevent the escape of the paraffin, and the syringe with the paraffin it contains and the needle to be used are dropped into the sterilizer and most carefully sterilized in boiling water. The syringe is then allowed to cool and the needle screwed into place ready to use. The patient requires no special preparation other than wash- 148 DISEASES OF THE NOSE, THROAT, AND EAR ing the skin of the nose with green soap, alcohol, and, finally, corrosive sublimate solution (1:1000). The end of the needle is inserted near the tip of the nose and thrust through the subcutaneous cellular tissue slightly beyond the deformity. Before beginning the injection the operator should assure himself that the point of the syringe- needle lies in the cellular tissue and hence is freely movable. The screw of the instrument is slowly turned and as the paraffin is pushed out through the needle it presses aside the cellular tissue and infiltrates it. The paraffin is molded into shape by the thumb and finger of the operator to the exact shape desired. The syringe-needle is then withdrawn a short distance, and more paraffin thrown into the cellular tissue, which is molded into shape; and so on, until the needle is finally withdrawn from beneath the skin of the nose. Before this is done care should be taken to break the thread of paraffin at the needle's point, so that paraffin will not be drawn into the skin as the point of the needle is withdrawn through it. The thread of paraffin is readily broken by grasping the point of the needle through the skin and rotating the instrument immediately before the needle is withdrawn. Not more than 20 minims of paraffin should be injected at one sitting, in order to avoid injurious pressure and the cut- ting off of the circulation sufficiently to cause sloughing. It should be borne in mind that the operation is so simple and painless that it can be repeated as often as necessary to accom- plish the desired result, so that it is foolish to attempt too much at one sitting. Little or no swelling follows the injection, and the after- treatment consists in confining the patient to bed for twenty- four hours as a precaution and keeping him under observation for some days. Iced cloths or a 25 per cent, solution of alu- minum acetate on cloths may be applied if edema or inflamma- tion seem to require it. Paraffin injections not only push the cellular tissue aside, but infiltrate it to a greater or less extent, so that if too much DISEASES OF THE NOSE 149 paraffin is injected it is impossible to remove it without re- moving the cellular tissue in which it is imbedded. After all inflammation has subsided the paraffin feels somewhat like a little mass of fat beneath the skin, and is readily movable upon the bone beneath. Unfavorable results from subcutaneous injections of paraf- fin have been reported as follows: Infection followed by slough or abscess. Infection can be avoided by careful sterilization and by care to avoid leaving a cylinder of paraffin extending through the skin to the mass beneath. Pressure necrosis, produced by injecting too much paraffin at one sitting or beneath the skin, where it is tightly bound down by adhesions. Deformity from hyperinjection or depositing the paraffin in the wrong place. Ordinary skill, prudence, and the proper technic will prevent such a disaster from occurring. Several cases of embolism have been reported from the in- jection of paraffin. When the paraffin is injected as a solid the danger is less imminent. It will, however, be well to have an assistant compress the sides of the root of the nose between his thumb and forefinger while the injection is being made. Paraffin remains only for some years beneath the skin, as it is finally completely absorbed, leaving behind it cellular tissue of the same shape and size as the paraffin. Congenital Deformities of the Nose.-The most common of the congenital deformities of the nose are a bulbous condi- tion of the end of the nose and extreme prominence of the bridge. The latter is readily removed in the following manner: An incision is made through the skin and periosteum down to the bone. The periosteum is then stripped from the bone and the parts exposed. It is now a comparatively simple matter to remove the redundant bone and cartilage by means of a chisel. The skin and periosteum are then placed in their former position and the wound brought together by buried 150 DISEASES OF THE NOSE, THROAT, AND EAR sutures, which leave no stitch-marks and a linear scar, which, in a year or two, becomes practically invisible. When bulbous enlargement of the tip of the nose is excessive the redundant skin and fat is best treated by the method of Rodman of Philadelphia, who removes a pear-shaped piece of skin and subcutaneous structures, being careful not to disturb the cartilaginous framework of the nose. In cases where the deformity is less pronounced, the operation devised by Roe of Rochester serves every purpose. The end of the nose is turned upward and backward and held with ? retractor by an assistant; then sufficient of the super- fluous tissue is removed or dissected out from the inside of the nose to allow the nose to conform to the desired shape. How- ever, great care must be exercised not to cut through into the skin, or a scar or dent in the external surface of the nose will result. DISEASES OF THE ACCESSORY SINUSES OF THE NOSE The cavities found in the bones of the skull communicating with the nasal chambers are the frontal sinuses, the antra of Highmore or the maxillary sinuses; the anterior and posterior ethmoid cells; the sphenoid sinuses and the lacrimal canals. The relative position of these sinuses in the face is shown in Fig. 70. All of tnese except the sphenoidal and frontal sinuses exist at birth. The frontal begins as a slight depression extending up from the nasal fossa in the third fetal month. The eth- moid cells appear in early fetal life as depressions which enlarge by the absorption of bone. The sphenoidal sinuses are pri- marily a constriction of the primitive nasal fossa which occurs in the third fetal month; but neither the frontal nor the sphe- noid are well-marked cavities before the age of seven nor fully developed before the twentieth year. Experiments upon pup- pies and other young animals indicates that full development of the accessory sinuses is dependent upon unobstructed nasal DISEASES OF THE NOSE 151 respiration. In a young animal occlusion of both nostrils causes death. Occlusion of one nostril is followed by imper- fect development of that side of the face including the accessory sinuses. As the result of senile changes the accessory sinuses increase in size after the age of fifty and the frontals of the aged some- times are enormous. Because of the conical shape of the orbits, the lateral masses of the ethmoids are narrower in front than behind and consist Fig. 70.-Relation of accessory sinuses, nasal'bones and cartilages, canaliculi and nasal ducts, and sac to surface. Projection upon surface of outei margins of orbital cavity of conjunctival sac, and of globus oculi upon surface: A, Antra of Highmore; F, frontal sinuses (the white cross above the right upper lid shows the relation of the supraorbital nerve to the frontal sinus; the black cross just beneath the lower lid indicates the relation of the infraorbital nerve to the antrum); N, nasal bones; 1, projection of margin of orbit upon surface; 2, projection of eyeball (globus oculi) on surface; 3, projection of conjunctival sac upon surface; 4, lacrimal sac; 5, nasal duct (from the lacrimal sac to the inner ends of both eye- lids the lacrimal canals can be seen terminating at the eyelids in the puncta lacri- malia); 6, lateral cartilage of nose (between the cartilage of each side is the carti- laginous portion of the septum, upon which they rest); 7, alar cartilages (Modi- fied after Eisendrath). of cells between nearly vertical walls: the os planum of the orbit and the ethmoidal portion of the lateral nasal wall. Above, the ethmoidal cells are capped by the frontal bone into which they partly extend; which is comparatively thick and contrasts strongly with the thin, fragile cribriform plate uniting the lateral masses of the ethmoid capsule, the os planum, the 152 DISEASES OF THE NOSE, THROAT, AND EAR lateral nasal wall, and the bony partitions between the cells and between them and the sphenoid antrum. The capsules are divided into anterior and posterior eth- moidal cells by the lamina of the middle turbinate (Fig. 78). Anterior to this lamina are the laminae of the bula ethmoidalis and that of the unciform process; while posterior are the lam- inae of the superior turbinate and of the partition between the ethmoid cells and the sphenoid antrum. The cells formed upon these laminae vary in size and shape and occasionally protrude beyond the normal limits of the labyrinthine capsule. For example an anterior ethmoidal cell may extend laterally over the orbit and anteriorly into the frontal bone. In cases where there is no frontal sinus, such an orbital cell may readily be mistaken for the sinus or lying in the frontal bone laterally to the sinus, for a double frontal sinus. One or more ethmoid cells sometimes occur between the orbit and the maxillary sinus and sometimes a cell develops above the sphenoid antrum. The appearance is that of an antrum divided into an upper and lower compartment by a complete partition. Such an ethmoid cell is always in intimate relation with the optic nerve which in some cases actually passes through it. The key to the understanding of the relationship of the ethmoid cells and the accessory sinuses is the position of their ostea. Those of the anterior ethmoidal cells invariably open into the nose beneath the middle turbinate and those of the posterior cells above it although because of the great variation in the shape and size of individual cells an anterior cell may extend back among the posterior cells or a posterior cell may extend forward among the anterior cells. In about 60 per cent, of cases the inferior bulla cell pierces the lamina of the middle turbinate to open above it and hence becomes a posterior ethmoid cell. The septum between the frontal sinuses at its anterior point of origin upon the floor of the sinus is almost invariably in the central line; but the septum instead of being in the median line and vertical, may extend laterally backward and upward in DISEASES OF THE NOSE 153 either direction and thus cause the sinuses to differ from each other greatly in size and shape; but both ostrea are invariably present and in the usual position. Both sinuses may be ab- sent, or only one exist, which may extend completely across the forehead. In such cases there is only one ostium and that in the usual position. Incomplete partitions may partly divide the frontal sinuses into several chambers but a "double" frontal sinus in the strict sense of the word does not exist as these partitions are never complete and there is always only one osteum to such sinuses. The sphenoid antrum also is sometimes partly divided into several chambers by incomplete lamina; but it invariably has but one osteum which is always located in the upper one-half, generally in the upper one-third of its anterior nasal wall posterior to a groove (spheno-ethmoidal sulcus); between the ethmoid and sphenoid and laterally to the posterior border of the superior turbinate. The septum of the sphenoidal sinus like that of the frontal at its base anteriorly is almost invariably in the median line; but as it extends upward and backward may be so distorted as to render the sinuses not only different in shape and size but one may actually extend beyond and back of the other. The posterior and inferior walls of the sinus are composed of thick bone. The anterior wall comprises an exposed or nasal portion in the upper half of which is the ostium and the thin partition between the posterior ethmoid cells and the antrum, which is a part of the ethmoid so that when a skull is disarticu- lated this partition comes away with the ethmoid, leaving a wide opening into the sphenoid antrum. Upon the superior wall of the antrum lies the optic nerve. Because of a dehiscence in the bone the nerve sometimes lies directly on the antral muc- ous membrane. Upon the external wall is the cavernous sinus with the internal carotid running through it. Because of not infrequent dehiscence in this location, the cavernous sinus may lie directly upon the mucous membrane resembling in this respect the intimate relation sometimes existing in the middle 154 DISEASES OF THE NOSE, THROAT, AND EAR ear between the mucous membrane and the bulb of the jugular vein; hence curetting the sphenoidal sinuses should be done only with the greatest caution if at all. The ostium of the maxillary sinus lies at the bottom of the infundibulum beneath the bula ethmoidalis. Unlike the other accessory nasal cavities there are not unfrequently one or more other openings into the antrum through the so-called "mem- branous" portion of the median wall, Fig. 77. The mucous membrane of all the sinuses is covered by ciliated epithelium so arranged that secretions, dust or bacteria are swept from the sinuses through the ostea into the nose and hence the comparative rarity of sinus infection in spite of the fact that congestion and mild catarrhal inflammation of one or more of the sinuses is not uncommon in acute coryza; and is manifested by characteristic headaches, which quickly subside providing the virulence of the infection is not sufficient to destroy the epithelium and the ostea remain patulous. Chronic purulent inflammation is usually the result of prolonged occlusion of an ostium or some focus of infection discharging into a sinus, as for example, a gangrenous tooth pulp into the maxillary antrum. Much can be learned of the topography of the accessory sinuses by sectioning dried preparations, but better results are obtained by hardening the specimen in formalin solution and then clipping away the bone piecemeal from the mucous membrane, which has become hard and resilient and perfectly retains the original shape of the accessory cavities. The accessory sinuses are phylogenetically ancient structures and, like the appendix, are residual organs, although their presence in the skull adds lightness without greatly diminishing the strength of the bones of the face and nose. The antrum of Highmore has its prototype in the amphibian accessory nasal chamber, which is an organ of smell. It is suggested that the sinuses become active when the individual is forced to breathe dry air and help supply the deficiency of moisture. The accessory sinuses are all supplied by the trifacial nerve, DISEASES OF THE NOSE 155 and this fact should be borne in mind in tracing the route of reflex phenomena. While the postmortem examinations of general hospitals upon cadavers dead from all causes show the presence of mucopus in about 33 per cent.; yet micro- scopic examination of the lining mucous membrane of the sinuses show pathological changes in only about 2 per cent, which corresponds more nearly with clinical observations upon the living. Differential Diagnosis between Diseases of the Accessory Cavities.-In disease of the antrum, the frontal sinus, and the anterior ethmoid cells the discharge appears anteriorly beneath the middle turbinate. That from the posterior ethmoids and sphenoid antrum in the olfactory slit or flows into the pharynx from the upper surface of the middle turbinate. If pus under the middle turbinate continuously reappears after being wiped away, it is not a local secretion but is the overflow from one or all of the first series of cavities mentioned above. The presence or absence of pus in the antrum is readily ascertained by needle puncture (see maxillary sinus). If after thorough lavage of this cavity, pus reappears beneath the middle tur- binate within an hour, its source is either the frontal sinus or the anterior ethmoid cells. If air is now blown into the frontal sinus by means of a cannula (see frontal sinus) and pus is forced out, its source is of course the frontal sinus. The ante- rior ethmoid cells are almost invariably diseased in frontal sinus suppuration. However, secretions from them may flow downward into the antrum but cannot flow upward into the frontal sinus. When the antrum is not infected but simply is a reservoir for the secretions of the frontal or anterior eth- moid cells, removal of the anterior end of the middle turbinate and if necessary the uncinate process prevents the entrance of pus through its ostium and this absence of pus can be demon- strated by needle puncture. Pus from the posterior ethmoids and sphenoid (second series of cells) appears in the olfactory slit or upper surface of the middle turbinate. Its source can usually be traced with 156 DISEASES OF THE NOSE, THROAT, AND EAR the nasopharyngoscope (Fig. 19). After cocainization it is sometimes possible to expose the ostium of the sphenoid with a long Killian speculum (Fig. 14) and see a pulsating bead of pus exuding from its ostium. In other cases it will be necessary to remove the posterior part of the middle turbinate to bring the Fig. 71.- 1, Frontal sinus, with probe entering it through the adnasal duct; 2, sphenoid antrum, with probe entering it through its ostium; 3, pharyngeal orifice of the Eustachian tube, with catheter in position; 4, Bowman's probe passed through the nasal duct into the nose, a portion of the inferior turbinated body has been cut away in order to show the point at which the probe enters the nose; s, m, i, superior, middle, and inferior turbinated bodies; o, ostium of the posterior ethmoid cells opening into the superior meatus; v, posterior portion of the Vomer; the rest of the septum has been cut away (from a dried preparation). sphenoid ostium into view. If, after washing out its sinus, pus reappears upon its anterior surface within half an hour, the source of the pus is the posterior ethmoid cells. If under these circumstances no pus can now be washed out from the sinus, it is probably not suppurating and any pus removed by the former lavage was seepage from the posterior ethmoids. DISEASES OF THE NOSE 157 Orbital abscess with consequent exophthalmos is most fre- quently the result of ethmoiditis but may result from disease of the sphenoid or frontal. From ethmoiditis the direction of the exophthalmos is outward and forward: from the sphenoid directly forward and from the frontal downward and forward. The pus is usually at first between the periosteum and the bone. The periosteum of the lamina papyracea may be dis- sected forward from the bone until it approaches the inner canthus or backward to the optic nerve. Ocular symptoms result either from the absorption of toxins, arterial or venous congestion or actual thrombosis of intercommunicating veins between the sinuses and orbit. The larger quantity of blood from the nose is carried into the ophthalmic veins; but there are no communications between the lymphatics of the accessory cells and orbit. In mild cases there is simply congestion of the conjunctiva and possibly epiphora and edema of the lids. Paralysis of the internal rectus and superior oblique sometimes result from ethmoid disease and ptosis from frontal sinus sup- puration. Only in rare instances does disturbance of vision occur from disease of the frontal or maxillary sinuses but the field of vision may be greatly restricted from sphenoid disease. There may be papillitis, neuroretinitis, choroiditis, or irido- cyclitis. Blindness results sometimes from direct pressure of inflammatory products upon the trunk of the optic nerve. Intracranial complications are phlebitis and thrombosis of the sinuses, meningitis, extradural, intradural and cerebral abscess. Facial neuralgia is most commonly caused by disease of the maxillary antrum. Crust formations on the middle turbinate are most common in ethmoidal suppuration, but may be present when there is a scanty discharge from either the maxillary or frontal sinus. Nasal polypi are most frequently the result not the cause of ethmoiditis and polypi may be present not only in the ethmoid cells but in any accessory cavity of the nose. Pain in max- illary or frontal sinus disease is usually referred to the sinus involved; but in the case of the ethmoid or sphenoid, headache 158 DISEASES OF THE NOSE, THROAT, AND EAR is vaguely deep seated or referred to the vertex or sides of the head. Supraorbital pain may result from suppuration of either the maxillary or frontal sinuses. Sinus headaches are increased by bending forward. Pain is not usually proportion- ate to the amount of fluid in a sinus but is often the result of "vacuum congestion," that is the negative pressure caused by the absorption of oxygen from the air contained in a sinus whose ostium is occluded. "Pressure pain" can .usually be elicited in disease of the frontal sinus by pressing with the tip of the forefinger upon the anterior wall just above the supra- orbital ridge, or more frequently by pressing upward upon the floor of the sinus at the inner angle of the orbit. Pressure in this position toward the orbital plate of the ethmoid sometimes causes pain when the anterior ethmoid cells are inflamed. Pressure in the canine fossa over a diseased antrum usually causes pain but in unilateral diseases of any nasal accessory cavity the degree of pressure tenderness should be compared with that of the opposite side. Vertigo and momentarily blurred vision when stooping forward may be present in disease of any of the accessory sinuses. The sense of smell may be perverted {parosmia) so that the individual imagines he smells a bad odor or may be impaired or entirely lost {anosmia). The latter is usually due to swelling of the ethmoidal mucous membrane or polypi preventing ventilation of the olfactory fissure. Inflammation of the antrum of Highmore may be divided clinically into: Acute and chronic catarrhal inflammation and acute and chronic purulent inflammation. Etiology.-The fangs of the first and second molar teeth usually extend into the floor of the antrum, the apex of the fangs not infrequently reaching a level above that of the rest of the floor of the antrum (Fig. 72). Under these circumstances it is easy to understand how caries of these molar teeth would in- fect the antrum, and undoubtedly gangrene of the molar pulp- cavities is a frequent cause of chronic suppuration. However, DISEASES OE THE NOSE 159 closure of the ostium maxillare as the result of hypertrophic rhinitis and polypoid degeneration of the mucous membrane about this opening preponderates in the etiology of empyema. Some acute cases can be traced directly to the effects of influ- enza. The antrum may also be infected from disease of the ethmoid cells, the frontal sinuses, the sphenoidal sinuses, syphilitic necrosis, etc. In some instances the frontal sinus Fig. 72.-Transverse section of the maxillary sinuses (Zuckerkandl). and the anterior ethmoid cells drain almost directly into the antrum; because the ostium maxillare is at the bottom of the infundibulum. Pathology. Soon after the onset of acute inflammation the mucous membrane of the antrum becomes greatly swollen and edematous and a large amount of seromucus is poured out. The inflammation may gradually subside at this stage provided the ostium is patulous or the secretion may become purulent. In old cases the cavity may be filled with foul, cheesy pus. The mucous membrane in some cases becomes enormously hy- 160 DISEASES OF THE NOSE, THROAT, AND EAR pertrophiecl, pulpy, and covered with granulations and polypi, with areas of exposed bone. Symptoms.-At the beginning of the attack there is a sense of fulness and pressure beneath the orbit, and pain, sometimes agonizing in character, involving the whole side of the face. In the more acute cases heat, swelling and redness occur over the affected cavities in inflammation of either the antrum or frontal sinus. Mastication is generally painful, the teeth of the affected side feeling as if elongated and crowded out of their sockets. These symptoms when due to a collection of fluid within the antrum and closure of the ostium maxillare may last for sev- eral days, when the fluid is either evacuated through the os- tium maxillare or by an opening through the thin median wall; in rare cases, the alveolus, the cheek, or the orbit. After this spontaneous evacuation the pus flows for a time, the course of the disease being marked by periods of retention, during which there is more or less pain, terminating by a discharge of some- what fetid pus from the nostril. Some cases, however, pursue a chronic course from the commencement, there being at no time complete closure of the ostium maxillare and retention, nor any well-marked symptoms, except a unilateral catarrh, general ill health, with perhaps evening rise in temperature, which may, perhaps, occasion the erroneous diagnosis of "com- mencing tuberculosis," and the possibility of antral inflamma- tion as a factor in the causation of acute articular rheumatism, pneumonia and asthma is worth consideration. Diagnosis.-A discharge of pus from one nostril, especially if periodic in character, which smells and tastes fetid to the patient, should always excite the suspicion of disease of the antrum. Upon inspection the pus will be found flowing from beneath the middle turbinated body. This pus should be carefully wiped away with absorbent cotton and the patient be directed to lie down upon the unaffected side for ten or fifteen minutes, when, if pus reappears beneath the middle turbinated body it is probable that its source is the maxillary antrum. DISEASES OF THE NOSE 161 If, while the patient is in a dark room, a 3-candle-power electric lamp is placed within his mouth, the face will be lit up by trans- mitted light, and the outlines of each antrum can be mapped out if both are empty. If one is inflammed that side of the face will appear darker. This is not due to the presence of pus; because the shadow will remain the same after this is removed, but to inflammatory thickening of the lining mucousmembrane. The observer should also observe the manner in which the light is transmitted into each nasal chamber, and more especially through the eyeballs. In some cases both sides of the face will be equally illuminated by the transmitted light; but if the pupil of each eye be observed, that of the unaffected side will be the brighter, and also a half-moon shaped portion of the lower eye- lid immediately below the eyeball will be more brightly illumi- nated. X-ray photographs often give valuable information as to the extent and size of the adnasal sinuses and presence or absence of disease; and in cases where it is suspected that dis- ease not only of the antrum but also of other accessory cavities exists, this means of information should not be neglected; but pathological conditions cannot be determined with certainty until the sinus has been opened, so that probably the simplest and most certain method of diagnosing the pres- ence of pus is the introduction of a Lichtwitz needle into the antrum. After thorough cocainization beneath the turbinate and the tip of the septum, the point of the needle is intro- duced beneath the lower border of the inferior turbinate and passed upward and backward until the middle of the attach- ment of the turbinate to the nasal wall is reached Fig. 74. In this position is the so-called "soft spot" where the wall of the antrum is usually so thin that no more force is required to penetrate it than to push a hypodermic needle through skin. However should hard bone be encountered in this locality, a few blows with a small mallet on the shank of the needle will overcome the difficulty. Before making the puncture the proximal end of the septum on which the shank of the needle rests is strongly bent toward the opposite side of the face so 162 DISEASES OF THE NOSE, THROAT, AND EAR that the point of the needle will penetrate the bone as nearly vertical to its surface as possible and the bevel of the needle point should be directed backward so that it will tend to penetrate the bone and not to slip along its surface beneath the mucous membrane. The thrusting of the small needle through the nasal wall should give no more pain than a hy- podermic injection. Air forced through the needle with a large syringe will bubble through the contents of the antrum if it is filled with mucopus producing a loud and character- istic bubbling noise. However it should be born in mind that in some acute cases the mucous lining of the antrum may be so swollen as to almost completely obliterate its cavity, so that the operator should be certain before blowing air with much force through the needle, that its point has completely pene- trated the lining mucous membrane. Because the floor of the antrum is rarely as high as that of the nose (Fig. 72) the needle will enter at a considerable distance above the floor of the antrum and if the fluid within does not reach this level, there will be no characteristic bubbling sounds produced by blowing air through the needle. Under these circumstances the antrum should be cleansed by syringing, normal salt solution into the antrum through the needle. If the patient's head is bent forward, the fluid will escape through the ostium and out of the nose and may be collected for examination in a bowl held by the patient. The salt solution is thrown into the antrum until no pus is washed out. The fluid remaining in the antrum is then removed by blowing air through the needle with the syringe. If it is impossible to syringe through the needle without undue force, the needle may not have entered the antrum, Fig. 74; it may be stopped up by a little spicule of bone, the ostium may be occluded, or the lining mucous membrane may be so swollen as to nearly fill its cavity. When its ostium is occluded, the pus should be asperated from its cavity. If the needle is stopped up, it should be withdrawn cleansed and reintroduced. DISEASES OF THE NOSE 163 Prognosis.-Resolution generally occurs in acute catarrhal cases, the result of transient closure of the ostium maxillare from simply taking cold. Chronic suppuration of the antrum rarely if ever gets well without operation. Treatment.-'Success in all acute cases of accessory sinus disease depends largely upon the restoration of ventilation and drainage. An effort should be made to restore the patency of the ostium maxillare in the following manner: The parts about the middle turbinated body should be thoroughly cocainized by means of pieces of absorbent cotton saturated with a 4 per cent, solution of cocain placed within the middle meatus, after which the parts should be sprayed first with a 10 per cent, solution of antipyrin and next with a 3 per cent, solution of menthol in olive oil, the parts are then covered with powdered calomel. These applications should be made daily at the physi- cian's office, the patient in the meanwhile using at home every hour or two a spray of adrenalin of the strength of 1:10,000. This treatment is curative in some mild catarrhal cases. However, if much muco-pus is washed from the antrum with a Lichtwitz needle when used for diagnosis, it will be necessary to repeat this irrigation daily: but if after twelve days pus is still washed from the antrum, the disease is probably an acute exacerbation of a chronic suppuration and more radical procedures will be required to bring about a cure. The accessory sinuses can be inflated with a Politzer bag or by Valsalva's method, that is, closing the nose and blow- ing violently into it. They may be aspirated by inserting the nozzle of a Politzer bag into the patient's nose and allowing the empty bag to expand while the patient is blowing out this cheeks. Closing the nostrils and sniffing violently has a tendency to aspirate the accessory sinuses. In some cases the rarefaction of the air by this method in an inflamed antrum is sufficient to cause pain, and in certain cases is sufficient to enable a patient to aspirate fluid from this antrum when in the horizontal position with the affected antrum uppermost. Formerly chronic suppuration of the antrum was treated 164 DISEASES OF THE NOSE, THROAT, AND EAR almost exclusively by the Cowper method. A molar tooth was drawn and the antrum entered through the inner root socket by means of a conical drill. Generally a carious tooth could be selected but when a sound tooth was sacrificed, the second molar was chosen. Occasionally the opening was made through the canine fossa and Fig. 73 shows a condition where it would be very difficult to enter the antrum through the alveolus. Fig. 73.-Illustrating the difficulty of opening the antrum through the root-cavi- ties when the antrum is small or abnormal in location. The antrum was washed out daily either by the surgeon or the patient. This method is still justifiable in necrosis when, after removal of one or more of the molars and surrounding necrosed bone, a large opening into the antrum results. It is astonishing in some such cases how quickly a cure of the suppuration results from a few daily irrigations. However openings from the mouth into the antrum quickly close if a plug of vulcanite or DISEASES OF THE NOSE 165 metal is not constantly worn to keep them open; and daily irrigation for years is sometimes unsuccessful in bringing about a cure. An opening through the nasal wall beneath the inferior turbinate closes more slowly because the bone is not very thick and if large sometimes remains open sufficiently long to bring about a cure of a chronic suppuration; because even without irrigation the antrum is cleansed by its secretions constantly escaping into the nose. Such openings are readily made either with or without the previous removal of the anterior third of the inferior turbinate, Fig. 74.-Section through the nose, showing needle (B) entering the orbita cavity through the middle meatus when the lateral wall slopes outward; A shows needle entering the antrum through the inferior meatus. Outline: Zuckerkandl, Anatomie der Nasenhohle (Coffin). with Wagner's punch, Weil's saw, Welaminsky's perforator' Well's rasp cannula, Gleason's perforator and rasp and by other methods. Should such an opening close prematurely, it is readily reproduced; because it is closed, not by the bone, but by thin cicatricial tissue which is easily penetrated and removed. The parts are cocainized as for an ordinary needle puncture. The triangular sharp end of Gleason's perforator is then placed upon the "soft spot" and a few half turns caused it to cut its way into the antrum. As it is withdrawn the bone is rasped away sufficiently to permit the introduction of the blunt end of the instrument and a sufficiently large opening quickly rasped from the antral wall into the nose. The opera- 166 DISEASES OF THE NOSE, THROAT, AND EAR tion is comparatively painless if the parts have been sufficiently cocainized. The antrum is irrigated each day either by the surgeon or the patient with an Eusta- chian catheter as long as there is any discharge, when the opening is allowed to close. Should ex- uberant granulations from the edge of the wound obstruct drainage from the antrum, they should be scraped away by introducing the blunt end of the instrument through the wound. The instru- ment is smooth on two sides so that it can be used without wounding any part of the edge of the opening which has cicatrized. For cleansing the antrum sterile norma salt solution is probably the most convenient, Ibut a saturated solution of boric acid may be employed. To either of these solutions a small proportion of hydrogen dioxide may be added. Foul odor is best overcome by syringing with i to 1000 permanga- nate of potash or i per cent, silver nitrate may be thrown into the antrum and after a few moments removed by syringing with normal salt solution. However in most chronic cases, alcohol gives the best results. After cleansing with normal salt solu- tion, the antrum is filled with 50% alcohol which is allowed to remain. Should this cause only mo- mentary discomfort the strength of alcohol is in- creased at subsequent sittings until 95 per cent, is used. When the secretions instead of being purulent and rendering the irrigation fluid flocculent become mucoid so as to form a jelly-like mass float- ing in clear irrigation fluid, the case is rapidly ad- vancing toward a cure. The permanency of the cure will depend largely upon the patency of the ostium maxillare and the condition of the struc- tures about this opening should receive careful attention. Radical Operations.-In some cases intranasal treatment Fig. 75.- Gleason's antrum rasp. DISEASES OF THE NOSE 167 is insufficient to bring about a cure of chronic suppuration. Radical or as sometimes called external operations have been devised by Kfister, Janson, Caldwell-Luc and Denker. Janson claims that when one sinus is involved, all the sinuses of that side of the head are probably more or less affected. In America the operation is employed mostly for the removal of malignant growths involving the antrum and nose. A post- nasal tampon is first placed in the nasopharynx. An inci- sion is made along side the nose, then below the nose to the columna and then through the lip into the mouth. The flap is dissected back to expose the anterior bony wall of the antrum. This together with the nasal process of the superior maxillary is removed as in the Denker operation. . The growth is then rapidly excised, the ethmoidal labyrinth is torn away with alligator forceps, the thin wall between the posterior cells and the sphenoid antrum is broken down and its cavity widely opened. In a number of cases of malignant growths operated by this method, the hemorrhage was easily controlled by packing with iodoform gauze and there was ample opportunity to carefully inspect the parts and remove all tissue that seemed infected. Caldwell-Luc Operation.-'The patient is etherized and the foot of the operating table slightly elevated. To prevent blood reaching the pharynx a strip of gauze is packed between the jaw and the cheek beyond the wound and removed from time to time as it becomes saturated with clots. In spite of this very important precaution a certain amount of blood usu- ally reaches the pharynx; especially during the later part of the operation and a mouth gag, tongue-depressor and long Kocher's hemostats for sponge holders should be at hand for its removal. The cheek and upper lip are elevated by means of blunt retractors and an incision made at the junction of the cheek and jaw from the posterior border of the alveolus to just below the nasal septum through the mucous membrane and perios- teum. The anterior and lateral walls of the antrum are now 168 DISEASES OF THE NOSE, THROAT, AND EAR uncovered by means of a periosteum elevator and the bone removed with chisel and rongeur forceps as far forward as the nasal wall and backward to the anterior border of the masseter muscle and vertically from the floor of the antrum to near the infraorbital canal. If the lining membrane is not wounded, the operation up to this point will be nearly bloodless. The mucous membrane is incised and the cavity of the an- trum examined with the finger and after hemorrhage has ceased, inspected. The hemorrhage which follows incision of the red and swollen mucous membrane will be profuse. It is con- trolled by packing the antrum with iodoform gauze, at least the mucous membrane of the floor of the antrum will probably be diseased beyond repair and require removing. This now is done by separating the mucous membrane from the bone by inserting a curette between them. When greatly inflamed and swollen Fig. 76.-Killian's frontal sinus chisel. it peels off readily and is often easily removed in one piece. The antrum is freed from blood, bony septa broken down and removed with the curette, and a larger opening made in the nasal wall. This is best started by making two rectangular cuts through the thin bone of the nasal wall with Killian's an- gular chisels (Fig. 76) care being taken not to penetrate the nasal mucous membrane if it can be avoided. The square plate of bone inclosed by the chisel cuts is carefully lifted off the nasal mucous membrane and the rest of the nasal bony wall cut away with curette and rongeur forceps. If possible the nasal mucous membrane is preserved and at the conclusion of the operation turned into the antrum to cover its floor. It adheres to the floor and shortens somewhat the time required for healing. The preservation of the nasal mucous membrane will be facilitated by placing the little finger within the nose from time to time while the bony nasal wall is being removed. However, if most of it is sacrificed during the operation, it DISEASES OF THE NOSE 169 need cause no anxiety as it does no harm except to lengthen the time required for healing. The lacrimal duct enters the nose beneath the inferior turbinate at the angle formed by its oblique and horizontal attachment to the antral wall. It is about on a level and not far from the infraorbital foramen, and is situated so high up that the greater portion of the nasal wall can be removed without injuring it. However, whether the duct is injured or not the patient generally has epiphora which after a time subsides. It is better to remove at least the anterior third of the inferior turbinate. The lower portion of the nasal wall should be removed so completely that there will be no ridge of bone between the nasal floor and that of the antrum. The operation is completed by inspecting all angles within the antrum for necrotic areas or diseased mucous membrane, which if found are removed. The remains of the nasal mucous membrane of the nasal wall of the antrum is now turned into the antrum to replace as far as possible its own mucous mem- brane and if necessary held in place with a stitch. The end of a strip of gauze is passed through the antrum into the anterior nares and the rest of the strip packed loosely into the antrum. The oral wound should not be stitched as it heals readily. The iodoform gauze is partly removed on the second day through the nose and the rest of strip on the third day. The after-treatment consists in syringing through the nose normal salt solution as long as there is secretion. During the healing, the antrum becomes greatly reduced in size. Denker's operation differs from the Caldwell-Luc to the extent that the anterior inferior angle of the antrum is obliter- ated by removing with chisel and rongeur the nasal process of the superior maxilla from the floor of the nose to the level of the infraorbital foramen. Diseases of the frontal sinus are acute catarrh or suppura- tion, chronic catarrh or suppuration, confined suppurations, mucocele, tumors, foreign bodies and local manifestations of syphilis, tuberculosis or some other systemic infection. Acute 170 DISEASES OF THE NOSE, THROAT, AND EAR catarrh of the frontal sinus probably is more common than similar disease of any of the other accessory sinuses. The disease, however, more rarely goes on to suppuration because the ostium often affords ample drainage from the most de- pendent portion of the cavity. Fig. 77.-This section shows part of the frontal sinus, the hiatus semi-lunaris, an accessory opening into the antrum, the inferior turbinal body, the Eustachian tube opening behind this and the sphenoidal sinus, with a partial septum near its center. In front of this sphenoid are the posterior ethmoid cells (not opened) and between these two is the sphenoethmoidal sulcus. The middle turbinal body has been lifted upward to show the structures beneath it. It remains attached by part of its upper edge to the ethmoid body (Douglass). The symptoms of acute sinus inflammation are frontal headache, sometimes severe pain, with nausea and vomiting. Redness and swelling over the sinus and edema of the eye lids. The infection extends to the meninges with characteristic symptoms, according to some authors more frequently in accessory sinus disease than in otitis. When a transilluminator is placed beneath the brow, the light is transmitted better by a DISEASES OE THE NOSE 171 large normal sinus than by one containing pus or a tumor. However, the size and shape of the frontal sinus varies so greatly in different individuals that a much more satisfactory result can be obtained by an x-ray photograph than by transillumi- nation. It is usually possible, by means of a good photograph, to not only determine whether the sinus contains pus or a tumor, but also secure valuable information as to its size, the presence or absence of septa, the condition and size of the ethmoid cells, the antra of Highmore, etc. It should be borne in mind that headache and even tenderness on pressure be- neath the eyebrow over the sinus sometimes results from pressure of a hypertrophied middle turbinate on the nasal septum. Treatment.-'The headache and pain can sometimes be re- lieved by cocainizing the parts and inflating the frontal sinus with menthol-iodin-chloroform vapor. Should this maneuver succeed, Politzer's bag should be used at sufficiently frequent intervals to prevent a return of the frontal headache. The patient should spray his nose every two hours with a i : 10,000 solution of adrenalin as a home treatment, and every effort should be made to maintain the ostium in a patulous condition until the inflammation of the frontal sinus subsides. Some- times the patient can aspirate fluid from the frontal sinus by closing the nostrils with the thumb and finger and attempting forced inspiration through the nose. The infundibiilum is a narrow groove in the outer wall of the nose. Its crescent- shaped opening into the middle meatus is the hiatus semilunaris. The frontonasal canal or duct, as the upper anterior portion of the infundibulum is called when it becomes a closed canal by becoming covered at its median side by the anterior attach- ment of the middle turbinate, generally extends upward from the infundibulum to the frontal sinus, where its opening is called the ostium frontale. However, in 50 per cent, of cases the upper portion of the infundibulum is not inclosed and hence there is no nasofrontal duct and the ostium opens directly into the middle meatus beneath the anterior extremity 172 DISEASES OF THE NOSE, THROAT, AND EAR of the middle turbinate. The distance from the floor of the frontal sinus through the nasofrontal duct if it exists is rarely more than f inch. The distance from the nasal end of the duct to the lower border of the bulla ethmoidalis, the lowest possible region of obstruction to frontal drainage, is about | inch (Fig. 78). When using adrenalin the patient should be Fig. 78.-1, 2, 3, 4, 5, Laminae or partitions of the uncinate process, bulla, middle superior and supreme turtenates. a, Posterior ethmoid cells, opening together with the sphenoid antrum c into the superior meatus; b, anterior ethmoid cells, opening together with the frontal sinus and maxillary antrum into the middle meatus; e, in- fundibulum leading upward to the osteum of the frontal sinus, d, when covered by the anterior attachment of the middle turbinate, the upper portion of the infun- dibulum is.converted into the naso-frontal duct; f, hiatus maxillaris; g, anterior portion of inferior turbinate removed to show lacrimal duct which is laid open. told to direct the spray from an atomizer so that it will reach the middle turbinate region. Not infrequently a small polypus is found beneath the middle turbinate anteriorly, and its removal is followed by a cessation of recurrent attacks of frontal sinus inflammation. However, the obstruction generally is due to hyperemia and swelling of either the lateral DISEASES OF THE NOSE 173 wall of the middle turbinated body or the mucous membrane of the infundibulum, the uncinate process, and the bulla ethmoidalis. Suitably treated, at least 95 per cent, of acute Fig. 79.-Sinus probe. This probe or sound is perfectly flexible and may be bent in any desired shape for sounding the frontal, maxillary or sphe- noidal sinuses. It is supplied with three markings showing the distance to the end of the sound (7 centimeters, 9 centimeters and 11 centimeters). These markings are invaluable when sounding the sphenoidal sinus as one can determine at a glance the depth to which the sound has penetrated. The instrument is also of use in determin- ing the consistency of tissues lying deep in the nose (.hypertrophies, polyps, etc.). cases recover without operation, but where relapses are fre- quent it is advisable to remove the anterior ethmoid cells. Fig. 8o.-Sullivan's frontal sinus rasps. Six sizes-'fitting into one handle. In a large proportion of cases the removal of the cells exposes the ostium and permits the introduction of a small curette or rasp by (Fig. 80) which the ostium if necessary may be still further enlarged at the expense of its anterior and lateral border. 174 DISEASES OF THE NOSE, THROAT, AND EAR Chronic Purulent Disease of the Frontal Sinus.-Symptoms. -'The headache is usually persistent, but may assume an inter- mittent type. There may be deep-seated pain on pressure on the floor of the sinus at the inner canthus. Upon inspection the parts about the infundibulum are red, swollen, and covered by a small amount of pus, sometimes offensive in character. If the discharge is greatly obstructed, the roof of the orbit may be so far crowded downward as to produce displacement of the eyeball with diplopia or even amaurosis. Should the posterior wall be necrosed, dulness, apathy, increased headache and other symptoms referable to the brain will probably mani- fest themselves. Meningitis or brain-abscess may occur. Treatment.-Chronic cases require irrigation with a mild alkaline solution. This may be accomplished by means of Hartmann's cannula (Fig. 81). This cannula should be made Fig. 81. Hartmann's frontal sinus cannula. The instrument should be made of pure, soft silver, so that its curve can readily be slightly changed. However* all of the accessory sinuses can be reached by a pure silver Eustachian catheter* which can, of course, be attached to a syringe. of virgin silver, so that its curve can be slightly changed to suit varying conditions. The parts are first cocainized and an effort made to probe the sinus with a small virgin silver probe (Fig. 77). As the distance from the vestibule of the nose to the ostium frontale is about 7 centimeters, the probe should be marked with rings at distances of 7, 9 and 11 centimeters from its tip. About 1 inch from its tip, the probe is curved somewhat abruptly at an angle of about 70 or 8o°. The region of the bula ethmoidalis is located and the tip of the probe inserted beneath the middle turbinate immediately in front of the bula so that the tip will rest upon the upper edge of the uncinate process. With this as a guide the tip of the probe is moved forward and upward until it is felt to enter a cavity which may be either the sinus or an anterior DISEASES OE THE NOSE 175 ethmoid cell. If the tip of the probe is in the sinus it will enter within the nose from 7 to n centimeters according to the size of the sinus. The tip of the probe will be also some- what freely movable within the sinus. If the operator is in doubt, he may withdraw the probe and place it alongside the patient's nose with its tip on the forehead in such a manner as to compare its curve with the contour of the patient's face and if necessary slightly change the curve of the probe before attempting to probe the sinus again. In many cases the nasofrontal duct is not a direct continuation of the infun- dibulum which ends either as a blind pouch or in an anterior ethmoid cell. The ostium frontale with or without a short duct opens under the anterior end of the middle turbinate in a line with the unciform groove and a little above it. Hence when the probe enters the blind pouch in which the infun- dibulum sometimes ends or enters an anterior ethmoid cell, it should be withdrawn and an effort made to locate the ostium frontale further back. Generally the probing is facilitated by bending the very tip of the probe laterally at an angle of 5 or 6°. As force is absolutely unnecessary, great gentleness should be used in probing the sinus; for the cribriform plate is not far distant from the field of operation. When the probe has entered the sinus, it is withdrawn; the shape of the cannula is bent to correspond with that of the probe, and inserted into the sinus. The solution used for syringing should be of a temperature of about 1200 F., and great gentleness should be employed in syringing to avoid giving pain. If necessary to improve drainage and facilitate cleansing and medication of the sinus, the ostium may be enlarged with Good's rasp or Suliran's files (Fig. 84). The use of these instru- ments usually destroy the naso-frontal duct and one or more of the anterior ethmoid cells. Should there be difficulty in probing the frontal sinus and the circumstances require it, the anterior ethmoid cells should be removed with a curette, after which the sinus is usually readily probed and its ostium enlarged with Suliran's files. As in the external operation for 176 DISEASES OF THE NOSE, THROAT, AND EAR exenteration of the ethmoid labyrinth (page 185) the lacrimal bone is the guide to the position of the anterior cells. This is readily located by pressing the forefinger tip into the tissues at the inner canthus, a medium sized mastoid curette, Fig. 201, is passed above the anterior attachment of the middle turbinate and its concave surface pressed firmly into the cells which are opened by rotating the curette backward and downward. The septa between the cells are then removed with alligator forceps. With the forefinger of the disengaged hand pressing on the lacrimal bone there is little danger of injuring either this structure or the os planum but should the orbit be pene- trated no harm results beside swelling and discoloration of of the eye lids which subsides within a few days (Mosher). After the sinus has been thoroughly cleansed, any retained fluid should be removed by blowing air through the cannula with the syringe. After the sinus has been cleansed and dried, I dram of a 10 per cent, solution of argyrol or alcohol 50 per cent, to 95 per cent., should be injected through the cannula by means of syringe a, Fig. 29, and allowed to remain. In many cases the discharge loses its fetid odor and becomes mucoid but never entirely ceases. However there is no head- ache except during acute exacerbations of the disease. Some of these cases are improved for the time being at least by the use of autogenous vaccines or injecting into the sinus of pure cultures of the Bulgarian lactic acid bacillus; but these meas- ures are sometimes inadequate to bring about a cure and an external operation for obliteration of the sinus is necessary. Killian states that the following conditions indicate an external operation. " 1. When other operations have failed. '*2. When there are indications of necrosis as a fistula or abscess. "3. When there are symptoms of intracranial complications. "4. When in a case of chronic purulent frontal sinusitis pain and fever appear with a foul smelling discharge. "5. When there is headache, particularly when associated DISEASES OF THE NOSE 177 with discomfort in the region of the eye, which is not relieved by intranasal treatment. "6. When in spite of oft repeated irrigations of the sinus, the discharge remains foul. " 7. When the inflammation of the frontal sinus and anterior ethmoid cells produces recurring groups of polypi. "8. When a simple purulent discharge is not relieved by careful intranasal treatment, and the patient desires perma- nent relief by a radical procedure." Bryan, Hajek, Killian, Agston, Luc, and Kuhnt have devised operations for exposing the frontal sinus by removing a portion of its external wall. Kiister, Lathrop, Beck, and others have devised osteoplastic operations in which a flap of periosteum and bone is replaced after the sinus has been curetted. Killian's Operation.-The field of operation is sterilized in the usual manner; the nostril is filled with a strip of selv- edged iodoform gauze which is removed and replaced from time to time as required during the operation. A mouth gag, tongue depressor and sponge holders should be at hand to remove blood that finds its way into the pharynx. A semicir- cular incision is made along the eyebrow from near its temporal end to the side of the nose and thence downward along the side of the nose to below the inferior border of the orbit whence, if necessary, it extends for a short distance outward. A some' what sharp hemorrhage from arteries near the root of the nose will necessitate the application of several hemostats. The periosteum is incised just beneath the inferior border of the temporal ridge and along the side of the nose, and the perios- teum and tissues of the orbit separated from the bone and held out of the way with an "eye protector. " For this purpose an ordinary tongue depressor may be employed, but care should be exercised during the entire operation that injurious pressure is not made upon the eyeball either by the "protector" or hemostats beneath it. A second incision through the periosteum is now made 178 DISEASES OF THE NOSE, THROAT, AND EAR about | inch above the superciliary ridge and parallel to its inferior border and the bone of the forehead, above this line denuded of its periosteum to the upper limits of the frontal sinus as determined by a. skiagraph before the operation. Should the frontal sinus be large and extend high up upon the forehead, it will be necessary to make a second incision through the skin and periosteum vertically from the first at the root of the nose, thus producing a triangular flap of skin and periosteum which is lifted up from the bone. The periosteum and bone of the superciliary ridge are left intact as a bridge, that as little deformity as possible shall result from the opera- tion. The width of the bridge should be about that of the base of the nasal bone of the side operated upon. As a con- tinuation of the base of the nasal bone at the completion of the operation it arches upward and outward to the lateral limit of the sinus. Extreme care is necessary at certain stages of the operation to avoid fracturing it. The periosteum is incised somewhat above the line of this bridge so that it can be turned over the superior surface of this bridge and form a covering for the upper surface of the bridge. The boundary of the upper border of the bridge is marked out by a groove made with Killian's triangular chisel (Fig. 76.) This groove is deepened by successive chiselings until the mucous membrane of the antrum is reached. The mucous membrane is pushed out of the way with a probe, and enough of the bone removed with a gouge to permit the probe being inserted in every direction between the mucous membrane and the bone and the boundaries of the antrum shown by the skiagraph verified. With chisel and rongeur forceps the entire outer wall of the frontal is removed. The swollen mucous membrane is now lifted up from the bone with a separator, and removed entire with a pair of forceps. As the mucous membrane when thickened and inflamed is attached very loosely to the bone its removal is usually a matter of little difficulty, a small gouge answering well as a separator. All overhanging ridges of bone are chiseled away, all angles of DISEASES OF THE NOSE 179 softened bone are smoothed down with a curette, so that no dead spaces remain when the wound is completed. The operator now proceeds to remove the floor of the autrum, and thus form a large opening into the nose. The periosteum of the orbit above and at the side of the nose is carefully separated from the bone until the lacrimal sac is reached which is lifted from its groove exposing the lacrimal bone which is punctured with a chisel and removed with alligator forceps (Figs. 44 and 82), exposing the anterior ethmoidal cells. Fig. 82.-Alligator forceps. The articulation of the nasal process, of the superior maxil- lary, the nasal bone and the frontal form a T-shaped suture which is readily perceived when the bones are bared of their periosteum. The floor of the frontal sinus lies immediately above where the vertical portion joins the horizontal portion of the T-shaped suture and the floor of the sinus should be removed with a gouge and also a sufficient portion of the nasal process of the maxilla to secure sufficient room for the use of alligator forceps (Figs. 44 and 82). At least the anterior ethmoidal cells are torn away with this instrument including the outer wall of the orbit (lamina papyraciae). When the entire ethmoid is suppurating the cells are bitten away with the forceps until the outer wall of the sphenoid is reached; which is also removed. The bony floor of the antrum, which is also the roof of the orbit, is entirely removed with the for- ceps and all angles smoothed down with a curette. A strip of selvedge-edged iodoform gauze is inserted from the antrum into the nose. Above this another strip of gauze is 180 DISEASES OF THE NOSE, THROAT, AND EAR inserted at the inner angle of the wound and another protruded from the outer angle. The skin wound is then brought together with sutures so arranged that the pulley of the superior oblique is brought as nearly as possible back into its original position. Because of the large opening into the nose the skin over the wound moves inward and outward with each breath of the patient. If this were allowed to continue, it would prevent the parts adhering by first intention and a pad of suitable size is adjusted over this region and held firmly in place with a Fig. 83.-Grooves made with the V-shaped chisels to form the upper surface of the bridge and to outline the portion of the frontal process of the maxillary bone to be removed. Fig. 84.-Extent of bone removed in Killian operation. bandage. If the temperature remains normal and the patient does not complain of pain the dressings are not disturbed for 48 hours when that part of the packing extending into the nose is seized with forceps and at least a part removed. The strips of gauze at the inner and outer angles of the wound are re- moved wholly or partly the next day. The patient is cau- tioned against blowing his nose after the operation but re- moves all secretions by sniffing them backward into the pharynx. After the removal of the nasal packing the nose is syringed gently once a day until healing is complete. DISEASES OF THE NOSE 181 One of the dangers of the operation is that the diploe of the frontal bone become infected with a slowly advancing osteo- myelitis usually fatal. Mucocele of the frontal sinus is a retention cyst containing a serous exudate from the mucous membrane. The contents of the cyst are prevented from escaping by partial or complete occlusion of the osteum frontale. Symptoms.-Pain, neuralgic in character, due to pressure caused by the accumulation. The pressure may be so great as to cause the tumor to bulge into the nose. The bone over the frontal sinus, especially the orbital portion, is painful on pressure. Treatment.-If the cystocele bulges into the nose, it should be incised and its contents allowed to escape. When there is no bulging into the nose and an x-ray photograph discloses the probable presence of a fluid within the frontal sinus, one of the endonasal or even an external operation must be done. Diseases of the Ethmoid Cells.-The most common are acute catarrh and suppuration; chronic hyperplasia, gener- ally with polypi and chronic suppuration generally without polypi. Hyperplasia is generally without purulent secretion and results from long-continued irritation. Pus indicates infec- tion and hyperplasia with pus signifies both irritation and infection. Chronic suppuration usually runs its course with- out polypi and is generally associated with necrosis of the intercellular bony walls. It may infect the orbit causing orbital abscess with exophthalms; or, especially in the young, may cause meningitis, often rapidly fatal. Pathology.-The mucous membrane of this portion of the nose extends inward to line the cells of the ethmoid. It is inseparable as a membrane from the periosteum beneath. The inflamed mucous membrane and cellular tissue, proliferat- ing after its kind, frequently forms masses of granulation tissue and polypi. When the deeper cells of the ethmoid are involved the pus, instead of finding its way into the nose, sometimes breaks 182 DISEASES OF THE NOSE, THROAT, AND EAR through into the orbit. Occasionally the anterior cranial cavity becomes infected and an epidural abscess may exist in this location for a long time without other symptoms then slight headache and irritability of temper. A trifling cause, such as a slight intranasal operation, especially in the middle turbinate region may spread the infection and change a latent localized meningitis into diffuse septic meningitis. Thrombosis of the longitudinal or cavernous sinus sometimes complicates ethmoidal suppuration. Symptoms.-In chronic hyperplasia a red and swollen middle turbinate may press upon the septum. Should both turbinates be diseased, the septum is nipped between the hypertrophied bodies, and reflex skin rashes upon the face, tinnitus and asthenopia, or other forms of eye disease may be present. In chronic suppuration there exudes a creamy, tenacious mucus, which the patient removes from his nose with great difficulty. At this stage of the disease nasal asthma and cough or unilateral paresis of the soft palate are reflex symptoms sometimes present. There is a sensation of pressure at the root of the nose, tenderness at the inner can- thus when pressure is made backward and inward toward the ethmoid. Acute ethmoiditis is occasionally an exacerba- tion of the chronic condition. All symptoms are exaggerated. There is pain at the root of the nose increased by pressure at the inner canthus. The middle turbinate and ethmoid is greatly swollen and covered with pus. There may be delir- ium at night and a sudden rise in temperature. Should symptoms of sinus thrombosis, meningitis or orbital abscess develop, an operation should not be long delayed. Bilateral exophthalmos indicates that the infection has probably ex- tended through the cavernous and circular sinuses and that an operation will probably not prevent pyemia or a fatal intracranial lesion. Treatment.-'The secret of success is the securing of ventila- tion and good drainage of the diseased area. Acute catarrhal cases recover almost spontaneously by the patient's use of an DISEASES OF THE NOSE 183 adrenalin spray at sufficiently frequent intervals. After cocainization, daily applications should be made by the phy- sician of a 10 per cent, solution of argyrol; a few drops of which are deposited in the infundibulum and also high up above the middle turbinate by means of a hypodermic syringe whose nozzle is a fine silver canula 8 or 9 centi- meters long. The fluid is often retained for an hour or more apparently by the capillary attraction of the nasal walls. In chronic suppurative cases, drainage from the ethmoid cells can be greatly improved by the removal of the middle tur- binate, either wholly or partly. The anterior attachment of the bone, which is nearly vertical, is severed with Beck- mann's scissors (Fig. 45), and the cutting continued somewhat as far back as necessary, and the loosened portion removed with a snare. In severe cases the ethmoid cells will require Fig. 85.-Ballenger's ethmoid knife. removal to secure efficient drainage. Ballenger removes the middle turbinate with a special probe- pointed curved turbinate bistoury. The probe point is in- serted beneath the turbinate posteriorly and the body severed from the attachment by drawing the knife forward. He has modified this knife by adding a right-angled blade to its tip, which necessitates that the instrument should be made in pairs, one for the right nostril and the other for the left (Fig. 85). The knife is passed through the nose with the right- angled portion of the blade hanging downward until the pharynx is reached. When the knife is rotated until the right- angled part becomes horizontal. The edge of the right- angled blade is inserted posterior to the middle turbinate and, by cutting first upward and then forward, a large portion of the ethmoid, including the middle and superior turbinates, is shaved off from its attachment to the sphenoid and. orbital 184 DISEASES OE THE NOSE, THROAT, AND EAR plate. The knife is removed by rotating the right-angled part of the blade up into a nearly vertical position and is with- drawn with the severed portion of the ethmoid adhering to it. Any remains of the partitions between the cells should be removed with alligator forceps. The cell walls are thinner and more fragile than the ethmoidal wall of the orbit and when operating it is ordinarily not difficult to differentiate between them. The lateral capsules of the ethmoid because of the conical shape of the orbits is wider behind than in front which should be borne in mind when drawing the knife forward. However, should a portion of the orbital wall or "lamina papyracea" be removed, the exposure of the orbital fat does not delay the healing. The after treatment consists in packing the ethmoidal region with iodoform gauze, should persistent hemorrhage require it. This gauze should be re- moved and renewed if necessary in 24 hours. However all nasal wounds heal more rapidly if the nose is not packed. The wounds should be cleansed with a syringe as often as necessary, care being taken during the first few days not to use sufficient force to cause hemorrhage. Fig. 86.-Hajek's ethmoid hook. When it is necessary to remove only the posterior ethmoid cells the method of Hajek is probably best. An incision as nearly vertical as possible is made with scissors through the middle turbinate in the region of the bulla, and the turbinate posterior to the cut is removed with a snare or alligator forceps the small Hajek's hook (Fig. 86) is inserted flatwise between the septum and the middle turbinate as high as possible without using force and its point turned outward and inserted into the most posterior ethmoid cell, and the nasal wall torn through by a strong pull on the hook. The pieces that remain hanging are now easily removed with alligator forceps. It should be borne in mind that the posterior wall of the ethmoidal DISEASES OF THE NOSE 185 capsule is the anterior wall of the pars ethmoidalis of the sphenoid antrum. This partition is as thin as those between the ethmoid cells and hence in cleaning up with alligator forceps after the operation of Ballenger or Hajek this thin partition not unfrequently comes away and exposes the cavity of the sphenoid antrum. When an orbital abscess has formed, it may be sufficient to open it through the eyelid and use a curette until a sufficiently wide opening has been made into the nose. The pus is usually under the periosteum of the orbit posterior to the lacrimal bone, and hence in searching for pus the knife should be thrust in this direction. However in most cases of orbital abscess, it is generally better to first establish by means of x-ray nega- tives the condition of all the accessory nasal cavities of the af- fected side. Not unfrequently the frontal or sphenoid sinuses, as well as the ethmoid, are involved in the suppurative process. In some cases a radical external operation is required. The patient is etherized and the Killian incision previously described is made through the inner half of the eyebrow down- ward along the side of the nose. The periosteum is separated from the bone into the orbit and the lacrimal sack, with the periosteum beneath, lifted from the groove in which it lies. As the periosteum is being elevated still further into the orbit, generally a gush of pus indicates that the abscess has been opened and the probe readily detects necrosed bone. With a curette the lacrimal bone is removed and the anterior surface of the ethmoidal labyrinth exposed to view. When the entire lateral half of its capsule is a mass of suppurating cells, as is often the case, it should be removed, including the middle turbinate and a sufficient surface of the lamina papy- racea to give room for the procedure. This is readily ac- complished by tearing away the bone piecemeal with alligator forceps. As the region of the sphenoid is approached, due care should be taken and its antrum opened or not at the discretion of the operator by removing the posterior wall of the ethmoidal 186 DISEASES OE THE NOSE, THROAT, AND EAR labyrinth. Because of the position of the optic nerve, cavern- ous sinus and internal carotid artery, it is unadvisable to curette the sinus or upper posterior ethmoid, but the last vestige of the cell structure should be broken down and removed with alligator forceps. The hemorrhage resulting from the exenteration of the lateral capsule of the ethmoid is readily controlled by sponging or packing the operation cavity from time to time with strips of iodoform gauze. It is probably better in most in- stances at the beginning of the operation to pack the naris with a strip of iodoform gauze to prevent blood trickling into the throat; and before its removal, the wound should be cleansed by syringing with warm normal salt solution. The wound is packed loosely with a strip of iodoform gauze, the end of which is brought out through the nostril and cut short. The skin wound is completely closed by sutures. At the end of from 24 to 48 hours the gauze packing is removed from the nose. The after treatment consists in gently cleans- ing the wound through the nose with normal salt solution once a day until the parts have completely healed. In this operation and the intranasal method for the removal of the ethmoid cells (page 176) the lacrimal bone is the landmark for the position of the anterior cells. After these have been opened the septa between the others including that between the posterior ethmoid cell and the sphenoid are readily broken down with a curette and alligator forceps. Empyema of the Sphenoidal Cells.-It is probable that catarrhal disease of the sphenoidal cells is of not infrequent occurrence. Generally it subsides spontaneously and the same is true of acute suppurations if the offending bacteria are of slight virulence and the ostium remains open. Symptoms.-Purulent discharge, seen by posterior rhinos- copy, or the nasopharyngoscope, flowing from above the middle turbinate into the pharynx. Pain, said by the patient to be located in the center of the head and radiating into the ears, and probably due to the pressure of retained secretions. Ocular DISEASES OE THE NOSE 187 symptoms vary from impairment of the field of vision to com- plete blindness. Because of the proximity of the cavernous sinus to the lateral wall of the sphenoid, septic thrombosis or fatal hemorrhage from this vessel may occur. The treatment should consist in the use of alkaline sprays and the application of alterative solutions to the mucous mem- brane of the upper part of the nose and vault of the pharynx by means of a syringe whose nozzle is a small silver canula (p. 183.) This treatment will suffice for the milder cases of catarrhal inflammation which tend to recover spontaneously. However, the opening into the sinus is as readily entered by the canula as by the probe as described below. The sinus is then cleansed with normal salt solution, 10 per cent, argyrol injected and allowed to remain. The ostium of the sphenoid is usually located in the upper third, practically always in the upper half of its nasal wall; except when an ethmoid cell lies directly over the antrum. From a surgical standpoint such a conformation may be re- garded as an antrum divided horizontally into two apart- ments, each with its ostium. That of the antrum proper will be much lower than normal while above anteriorly is that of the ethmoid cell. The ostium usually lies deep in the sulcus between the sphenoid and the ethmoid cells and is completely hidden from view by the posterior border of the middle turbinate. After thorough cocainizations, it can sometimes be exposed by in- serting Killian's speculum (Fig. 14) between the septum and the middle turbinate. When the antrum is suppurating, a pulsating drop of pus will sometimes be seen protruding from the ostium. If a straight probe (Fig. 83) is passed over the exact center of the middle turbinate it will strike the anterior wall of the sphenoid (Zuckerkandl's line) generally sufficiently near the ostium for it to be found by gently manipulating the probe in various directions but more especially laterally. It may be necessary to slightly bend the very end of the probe so that it 188 DISEASES OF THE NOSE, THROAT, AND EAR will penetrate more deeply into the spheno-ethmoid sulcus before the ostium is located. The distance from the anterior, inferior nasal process to the sphenoid ostium is rarely over 7I mm. even in large heads: so that if a probe passes along Zuckerkandl's line for a dis- tance of from 8 to 10 cm. it may be assumed to have entered the antrum. Generally the probe enters the antrum with a little jerk as if a slight resistance had been overcome, because the bone about the ostium is very thin and its im- mediate edge consists only of mucous membrane. In sup- purative cases when the probe is withdrawn from the antrum its end will have a fetid odor. Should this method of probing the sinus prove a failure, the posterior ethmoid cells can be removed and the anterior wall of the sinus destroyed by the method of Hajek: " After complete anesthesia (local or general), I introduce my ethmoid hook into the posterior part of the rima olfactoria against the anterior wall of the sphenoid sinus as high as pos- sible without using the slightest possible force. Since the point of the hook is always directed inferiorly an injury to the lamina cribrosais absolutely excluded. I then turn the hook so that the point penetrates the internal wall of the ethmoid labyrinth. When I now press the handle of the hook against the septum I am sure that the hook has penetrated deeply into the ethmoidal labyrinth. The internal (nasal) wall of the labyrinth with that portion of the middle turbinate which lies beneath is torn through by means of a strong pull on the hook. The pieces which remain hanging can easily be removed with a pair of good nasal forceps or the conchotomes of Grunwald or Hartmann. The advantage of the hook in this procedure is not to be underestimated. It is so slender that its point can be easily seen and followed during every phase of the opera- tion, while the curette hinders the light and requires too much room. . . . The bleeding is usually trivial and is almost always controlled by wiping with sterile gauze. ... I now proceed to resect the anterior wall of the sphenoid sinus. To this end DISEASES OF THE NOSE 189 I use my bone forceps, but the ostium sphenoidale must have a definite width before we can introduce them into the sphenoid sinus. This I accomplish by means of my hook, tearing the inferior edge of the ostium piece by piece until the opening is sufficiently large to permit the passage of the bone forceps." Skillern has modified the hook and punch forceps of Hajek. Because of the difficulty of introducing the hook, he devised a double hook or "evulsor" (Fig. 88). This is readily inserted through the ostium but is so constructed that it is prevented Fig. 87.-Skillern-Hajek's sphenoid punch. from penetrating too deeply and wounding the posterior or upper wall. When the instrument has entered the antrum, its hooked blades are widely separated and withdrawn tearing outward the thin antral wall. The evulsor is then reinserted, turned horizontally and withdrawn from the antrum. In this manner a large portion of the anterior wall is removed so that the punch forceps are readily introduced. Skillern has had the distal extremity of Hajek's punch forceps slightly curved, so that it more readily grasps the lower part of the anterior wall of the antrum, where the bone is thicker than above. With the punch the whole anterior wall of the antrum is removed and 190 DISEASES OF THE NOSE, THROAT, AND EAR so large an opening established that it will be many months in closing. However, should exuberant granulations tend to close the opening prematurely, they are removed with a curette and the parts touched with a 12 per cent, solution of nitrate of silver. In operating care should be taken not to injure the upper wall because on it lies the optic nerve; nor the lateral wall Fig. 88.-Skillern's evulsor. because of the proximity of the cavernous sinus with the in- ternal carotid passing through it. Because of dihiscences in the bone either the nerve or the sinus may be covered only by mucous membrane. Should the cavernous sinus be wounded the hemorrhage will be profuse. The operator should at once introduce the forefinger of the left hand behind the palate and endeavor to insert its tip into the antrum or at least temporarily close the instrumental opening in its anterior wall with his finger-tip. A strip of iodoform gauze is then carried through the nostril by means of a pair of forceps and packed into the antrum. This will control the hemorrhage. Douglass who recommends this method, states that the gauze should not be interfered with before the third day and then removed, slowly and with great gentleness and caution. The after-treatment consists in simply cleansing the parts with normal salt solution and preventing the premature closing DISEASES OF THE FJOSE 191 of the opening into the antrum. In most cases the mucous membrane of the antrum quickly assumes a normal appear- ance if there are no retained secretions. Accidents and Dangers of Operations on the Accessory Cavities.-The region of the supra- and infraorbital foramina should be respected as far as the exigencies of an operation will permit; although cutting the nerve in either locality produces no greater disaster than a feeling of numbness and slight discomfort which may persist for years. The lifting of the lacrimal sack from its groove should be done with sufficient care to avoid tearing the sack and the nasal orifice of the duct should be avoided if possible. However it is difficult to understand why simple resection of the duct at its inferior portion during a Caldwell-Luc operation should lead to infection of the duct and stricture but this sometimes occurs, and necessitates probing and medication or the wearing of a style. Injuries of the orbit through the nose are some- times attended by disastrous results. In such cases, a punc- ture, because of the lack of proper drainage if the orbit becomes infected, is more dangerous than the removal of a considerable portion of its bony wall as in a Killian operation. Fig. 74 shows how readily the orbit might be punctured when the needle is thrust through the middle meatus, when the antrum is small. Douglass observed a case where the antrum was greatly narrowed by a curious guttering of the orbital floor to the extent that the orbit might readily be punctured by a needle thrust beneath the inferior turbinate in the usual position. In a case reported by Seaman, washing the an- trum through the alveolus with 1-2000 bichloride solution resulted in infection of the contents of the orbit including the optic nerve. Vision in both eyes was ultimately lost. The same author relates an instance where an operation in the ethmoid region was followed by haematoma of the orbit, exophthalmos and ultimate blindness with divergent squint. However the prognosis as far as permanent injury to the eye in orbital hemorrhage is good when prompt measures are 192 DISEASES OF THE NOSE, THROAT, AND EAR taken to relieve injurious pressure. The same remark applies to the accidental injection of a moderate amount of sterile normal salt solution into the orbit. In cases where emphysema of the orbital tissues result from fracture of the orbital plate of the ethmoid, the prognosis is also good. The only treat- ment necessary being a light pressure bandage and the avoid- ance of sneezing and blowing the nose. The danger of osteomyelitis after the Killian operation has been alluded to. If in an operation upon the accessory sinuses, the dura is exposed, the same rules apply as in mastoid operations. The exposure should be made sufficiently large to afford ample drainage. If the dura is accidentally punctured it should be incised through the puncture to the extent of half an inch as such wounds are less likely to cause meningitis, than punctures. Reference has been made to danger of curetting the sphenoid antrum because of the proximity of the optic nerve and great blood vessels. However, curetting the upper por- tion of the lateral wall of the most posterior ethmoid cells is also dangerous, and even unnecessary probing of this region should be avoided. THE PHARYNX ANATOMY OF THE PHARYNX The pharynx is a conic, musculomembranous bag suspended base up from the basilar process of the occipital bone. It extends downward to the lower border of the cricoid cartilage and fifth cervical vertebra, where it merges into the esophagus. It is composed of three layers-an inner, mucous; a middle, fibrous, sometimes called the pharyngeal aponeurosis; and an outer, muscular layer. At birth the nasopharynx is nearly as long anteroposteriorly as in the adult, but is relatively very low, being merely a narrow passage, running backward and downward from the constricted posterior nares. Consequently, the soft palate is more horizontal than in the adult. The height of the naso- pharynx increases with the development of the posterior nares. At birth their height is from 6 to 7 mm. and the breadth between the pterygoid process about 9 mm. For the first six months the height of the nasal passages increases rapidly to double the size at birth, after which the increase is relatively slow. The nasopharynx is very vascular, with an abundant supply of lymph-glands, so that its lymphoid ring is well developed at birth. Relations of the Pharynx.-Posteriorly the pharynx is con- nected by loose cellular tissue with the first five cervical vertebrae (Fig. 71). The first, or Atlas, forming a promontory extending forward into the pharynx on a level with the palate. On each side posteriorly are the longus colli and recti capiti antici muscles. Laterally are the styloid processes with their muscles, the internal carotid arteries, the internal jugular vein, the eighth, ninth, and sympathetic nerves. Near its 193 194 DISEASES OF THE NOSE, THROAT, AND EAR apex are the lobes of the thyroid gland, the common carotid and lingual arteries, the lingual nerves, and the sternohyoid muscle. Divisions.-The pharynx is divided into the nasopharynx, sometimes called the posterior nasal space, the oropharynx, and laryngopharynx. The nasopharynx extends downward to the edge of the soft palate, the oropharynx from this to a line drawn through the cornua of the hyoid bone, and the laryngo- pharynx the rest of the distance to the commencement of the esophagus at the fifth cervical vertebra. Attachments.-The pharynx is attached to the internal pterygoid plate, pterygomaxillary ligament, inferior maxillary bone, base of the tongue, cornua of hyoid bone, stylohyoid ligament, and the thyroid and cricoid cartilages. Muscles.-There are seven muscles-the superior, middle, and inferior constrictors, two stylopharyngei, and two palato- pharyngei muscles. The latter, covered by mucous membrane, form the anterior pillars of the fauces, the stylopharyngei, the posterior pillars. A not very uncommon anatomic peculiarity is that one or both the palatopharyngei are completely sur- rounded by mucous membrane, so that a probe can be passed betweem them and the rest of the outer wall of the pharynx. Arteries.-There are four arteries supplying the pharynx- two branches of the external carotid and two branches of the internal maxillary. These are the ascending pharyngeal and branches from the superior thyroid; descending pharyngeal and pterygopalatine. Occasionally arteries as large as the radial are seen pulsating on either side beneath the mucous membrane of the pharynx. These are supposed to be displaced occipital arteries. Nerves.-The pharynx is supplied by a plexus composed of branches from the pneumogastric, glossopharyngeal, superior laryngeal, and the superior cervical ganglion of the sympathetic. The mucous membrane of the nasopharynx is covered with stratified, ciliated, columnar epithelium, the oropharynx with squamous epithelium, and the laryngopharynx with squamous ANATOMY OF THE PHARYNX 195 posteriorly, and ciliated epithelium anteriorly. There are simple follicular glands, compound follicular, and racemose glands. Tonsils and Lymphatics of the Pharynx.-The laryngo- pharynx has few or no lymphatics. Above the supply is pro- fuse, being located mainly in the mucous membrane of the superior and posterior wall. The tonsils are a part of an irregular ring of adenoid tissue surrounding the pharynx and continuous with the general lymphatic system. There are seven tonsils: 2 faucial, 2 tubal, 2 lingual, and the pharyngeal. The faucial tonsils are situ- ated one on each side of the fauces between the anterior and posterior pillars of the fauces. The lingual tonsils are situated at the base of the tongue, the tubal tonsils at the pharyngeal Eustachian orifices, and the pharyngeal tonsil in the vault of the pharynx posterior to the nasal orifices. Any of these tonsils when hypertrophied may cause annoying symptoms, but the lingual tonsil is more apt to prove troublesome after middle life if at all, while hypertrophy of the faucial and pharyngeal tonsils are generally diseases of childhood. The faucial tonsils are oblong in shape with their long axis vertical. At birth they are i to f inch long and to A inch wide. The tonsils develop in size up to the sixth or eighth year, when they are 1 to i| inches long, f to 1 inch wide, and from 4 to 1 inch in thickness. They are frequently swollen without infection during the eruption of teeth at the 2d, 6th, 12th, and 17 th years and carious teeth probably are frequent causes of tonsillar infection. The tonsils consist of lymphoid masses held together by a trabecula of connective tissue containing the vessels and nerves, and are surrounded, except on the free surface, by a capsule or sheath. The faucial sur- face is covered by an extension of the adjacent mucous mem- brane, with its stratified epithelium extending inward'to line the crypts. Above the tonsils and between the anterior and posterior pillars is situated the triangular fossa supratonsill arts. Here 196 DISEASES OF THE NOSE, THROAT, AND EAR a number of crypts extend vertically into the tonsil, the reten- tion of whose excretions plays an important role in the pro- duction of peritonsillar abscess. The number of crypts, both vertical and horizontal, rarely exceeds fifteen for each tonsil. They vary in length from | to | inch or even more in tonsillar hypertrophy (Fig. 94). The tonsils are frequently attached to the anterior pillars in such a manner as to form pouches, which are effective culture-tubes for the propagation of pathogenic organisms, and the anterior lower third of the tonsil is often covered by the hyperculum plicatriangularis, a triangular fold of mucous membrane extending from the anterior to the posterior pillars downward and backward across the tonsil. This fold may interfere with the drainage of the crypts it covers or form a pocket of retained secretions. It should be removed with the tonsil in tonsillectomies. Its anterior, inferior border is firmly attached to the tonsil and anterior pillar where it forms a sort of ligament which when cut permits the tonsil to be drawn toward the median line of the pharynx away from the pillar and opens the cellular space external to the capsule for the introduction of an enucleation instrument. When diseased, the crypts sometimes branch and communi- cate with each other in such a manner as to retain lymph and epithelium cells; so that cholesteatomatous masses collect whose decomposition imparts a fetid odor to the breath. The faucial tonsils drain into the deep lymphatics of the neck, so that systemic infection may occur by way of the thoracic glands and duct, or the apex of the lung may be, it is said, infectd with tubercle bacilli from the tonsil by way of these glands. The tonsils themselves lie too deep to be felt through the skin of the neck and according to Wood the deep lymphatic or "tonsillar gland," into which the tonsil empties, lies external and slightly anterior to the internal jugular vein. Hypertro- phy of this gland means its dislocation outward and forward, but generally it can be pushed back beneath the sternomastoid ANATOMY OF THE PHARYNX 197 muscle, which is not the case with hypertrophied superficial lymphatics. According to Deaver, the tonsils are supplied with blood from the ascending pharyngeal branch of the external carotid, the tonsillar and ascending palatine branches of the facial artery, the dorsalis lingua branch of the lingual artery, and the descending palatine branch of the internal maxillary artery. Externally, the tonsil is separated from the internal carotid and the ascending pharyngeal artery by the superior constrictor muscle and the pharyngeal aponeurosis. Of these vessels the ascending pharyngeal is the more apt to be injured by opera- tions for the removal of the tonsil, because it lies directly oppo- site the tonsil on the external surface of the superior con- strictor. Malignant growths of the tonsil are best removed through an incision made parallel to the anterior border of the sternomastoid, because the involved lymphatics cannot satis- factorily be removed through the mouth. The line of incision for ligation of the external carotid is parallel to the anterior border of the sterno cleidomastoid muscle, from the angle of the jaw to the cricothyroid membrane. Working from below upward by dry dissection the superior thyroid artery is soon encountered, which serves as a guide to the external carotid, which should be tied below the origin of the ascending pharyn- geal, which means as close to the junction of the external and internal carotids as possible. However in operations upon the tonsils it is usually the veins and not the arteries that cause troublesome hemorrhage. There are two large veins, one close to the anterior lateral border of the tonsil behind the anterior pillar and the other close to the posterior lateral border behind the posterior pillar. Both are in the cellular tissue external to the capsule and are usually avoided in tonsil- lectomies but when either is torn or cut the hemorrhage is profuse but usually readily controlled by digital pressure through a gauze sponge. The functions of the tonsils are similar to those of other lymphatic glands. As a part of the hemopoietic system they 198 DISEASES OF THE NOSE, THROAT, AND EAR form young lymphocytes most of which pass into the circula- tion, but some escape to the free mucous surface, and carry off with them effete products. The tonsils are most active during youth, while the thymus, a large blood-forming gland, is atrophying. There is consid- erable difference of opinion as to the phagocytic action of the tonsils, some authorities claiming that the tonsils constitute a weak part of the throat and expose the system to the inroads of diphtheria, tuberculosis, syphilis, acute articular rheuma- tism, and other diseases. In evidence of the difference in the behavior of tonsillar epithelium toward dust and bacteriae, Jonathan Wright dusted carmin over the tonsil. Fifteen minutes later all the particles of carmin had passed through the epithelium into deeper layers and could be detected in sections under the microscope; while bacteria, situated at the exact point where the carmin entered, remained quiescent and unabsorbed. Good has endeavored to prove that the chief function of the tonsils is to establish immunity to infection especially early in life. Secretions from the nose are carried toward the tonsillar crypts as demonstrated by Jonathan Wright. Secretions from the lungs are coughed or carried toward the tonsils and in vomit- ing, the contents of the stomach are brought directly in contact with the tonsils. Hence bacteria that have entered the mouth or nose are directed toward the tonsillar crypts, which are lined with stratified epithelium and the mucus within them serves as a culture medium for the development of vaccines which enter the lymph current of the tonsil and are carried into the entire system, where they come into contact with the fixed cells and excite them to produce antibodies such as opsonins, agglutinins, etc., and thus produce immunity. Until immunity is established, the lymphocytes of the tonsil- lar secretions have no great affinity for bacteria which conse- quently flourish; but when immunity is established for the variety of bacteria within the crypts, their secretions contain opsonins and hence the lymphosites attack the bacteria and DISEASES OF THE NASOPHARYNX 199 destroy them by phagocytosis. In the act of deglutation the tonsils are squeezed by the superior constrictor and their contents emptied into the pharynx. Agglutination and bac- teriolysis can also take place in the tonsils, their interfolli- cular connective tissue is composed of interlacing fibers whose interspaces are filled with lymphocytes and polyneuclear leucocytes which offer every protection to the general system from bacteria that pass through the epithelium of the crypts: so long as the tonsillar functions are not so altered by disease as to render the tonsils a possible portal for systemic infection, and not a protection. According to the experiments of Ott and Scott, injection of an extract of powdered tonsil into an animal produced at first a great fall in blood pressure followed by a rise, above normal and a slower and stronger heart beat. The amount of urine was also increased many times the normal amount. DISEASES OF THE NASOPHARYNX OR POSTNASAL SPACE Postnasal catarrh may be either secondary, as when a nasal accessory sinus discharges into the postnasal space, or the disease may be primary, and extend to either the nose or Eustachian tubes. The nasopharynx may be blocked by pos- terior hypertrophies of the turbinated bodies or by polypi, cysts, fibroid tumors, or malignant growths springing from the posterior nares or from the vault of the pharynx. A somewhat common affection beginning generally in childhood is hyper- trophy of the pharyngeal or Luschka's tonsil. Adenoid vegetations or hypertrophy of the pharyngeal tonsil is an overgrowth of the normal adenoid tissue of the pharyngeal vault. The affection is often associated with hypertrophy of the faucial tonsils, and generally commences in childhood, but may be met with in patients of any age. Symptoms.-If the adenoid vegetations are at all large they block up the posterior nares and compel mouth-breathing, 200 DISEASES OF THE NOSE, THROAT, AND EAR the pinched nostrils and half-open mouth giving the face a vacant and well-nigh idiotic expression (Fig. 89), which ordinarilly disappears as soon as nasal respiration is rees- tablished. However, if mouth-breathing be continued into adult life permanent deformity of the bones of the face and even of the chest results. Breathing is audible sometimes Fig. 89.-Typic appearance in adenoid vegetations: boy ten years old (Friihwald). during the day and there is always loud snoring during sleep. The voice is toneless, articulation is indistinct, and the hearing is often impaired. Treatment.-Adenoid vegetations tend to no longer obstruct nasal respiration as the individual passes into adult age and the nose and nasopharynx grows larger, but may, in the meantime, have produced irreparable injury to the ears and altered the shape of the bones of the face. Application of Formula 112 to the postnasal space will sometimes bring about a slow ab- sorption of the hypertrophied tissue. In children, when the DISEASES OF THE NASOPHARYNX 201 growth is not large, such applications should be made by the surgeon two or three times a week, the parents in the mean- time cleansing the nose night and morning with the spray from an atomizer containing an alkaline wash and afterward placing in each of the child's nostrils a mass the size of a pea of gallic acid ointment 5 to 10 grains to the ounce of vaselin. The child should then lie on its back for a few moments until the ointment melts and runs into the nasopharynx. However, the only treatment adequate in the majority of cases is a thorough removal of the mass by surgical procedures. In adults post- Fig. 90.-Juracz's adenoid forceps. nasal cutting forceps (Fig. 90) may be used; the operator being careful to begin operating in the median line, and work- ing from it in each direction until the entire mass is cut and torn away from its attachment, at the same time being exceedingly careful not to wound the orifices of the Eustachian tubes. In children or in adults, when the pharyngeal tonsil is still comparatively soft, a curette (Fig. 91) is a most efficient instru- ment. Young children should be seated in the lap of a nurse upon a piano stool opposite the operator, in the same manner as for an ordinary examination of the nose and pharynx. The murse passes her arms beneath those of the child and places her hands, one on each side of the child's forehead, in such a manner as to control the movements of the head. The nurse then elevates her elbows so as to bring the child's arms into such a position that it is impossible for the child to reach its mouth with its hands. The curette is now passed behind the palate, and the handle of the instrument depressed until the 202 DISEASES OF THE NOSE, THROAT, AND EAR outer edge of the ring is felt to rest against the septum. By sweeping the ring upward, backward, and downward against the pharyngeal wall the growth is brought within the curet.e and is cut from its at- tachment. Without removing the instrument from the mouth the maneuver is quickly repeated at each side of the median line, in order to be certain that the major portion of the growth has been removed. The operation should be performed quickly, but with gentleness, little force being re- quired to sever the growth from its attachment. The nurse then releases the child's head, and the operator passes his left arm around the child's head and thrusts his fore- finger hard against the child's cheek, in such a manner that the cheek protrudes between the child's open jaws, so as to form an efficient mouth-gag. The oper- ator then quickly passes the fore- finger of his right hand behind the child's palate until the posterior edge of the septum is felt. The posterior nares, Rosenmuller's fossae, and the vault of the pharynx are inspected, as it were, by the sense of touch. If any shreds of the growth remain they are removed with the finger-nail, Fig. pi.-Adenoid curettes. The original Gottstein curette was de- signed for scraping rather than cut- ting. The improved form is shown at D, whose cutting edge should be kept sharp in order to easily sever the growth. Fetterolf's modifica- tion, A. B, C, consists in the attach- ment of a spring clamp, serrated in such a manner as to firmly grasp all adenoid tissue cut from the pharynx. The set consists of three, with vary- ing angles to the blade and different lengths of crura, in order that no matter what the shape of the pharynx or the situation of the growth it can be reached and re- moved by one of the instruments. DISEASES OF THE NASOPHARYNX 203 scraping them from below, upward, and forward. Before removing his finger the operator should spare no pains to assure himself by the sense of touch not only that nothing remains to obstruct nasal respiration, but that Rosenmuller's fossae are freed from any mass likely to interfere with the blood-supply of the Eustachian tubes. The hemorrhage following the operation is generally trifling and the after-treatment consists in simply keeping the parts clean with an alkaline wash. When a general anesthetic is employed it should be ether and not chloroform, because in this condition, the so-called "habitus lymphaticus" of Kalisco, chloroform is especially dangerous, somewhat numerous deaths having been reported. Ether is not necessary to secure an adequate removal of the hypertrophy. However, the major portion of successful operators prefer to operate under ether, stating that the operation then can be done more deliberately, and there is less danger of failure to remove all portions of the hypertrophy. The patient's mouth is opened widely with a mouth-gag in the hands of an assistant, and the operator carefully explores the nasopharynx with his forefinger to ascertain its shape and the size and attachment of adenoid tissue. The finger is then removed from the mouth, the tongue held down with a tongue depressor, and a suitably shaped guarded curette (Fig. 91) inserted in such a manner that its blade glides along the posterior border of the septum and encircles the adenoid mass, which is cut away and held by the serrated spring as the blade sweeps upward, backward, and downward in close contact with the nasopharyngeal wall. The operator's forefinger is re- introduced behind the soft palate and shreds of adenoid tissue are either rubbed away with the finger-tip, covered by gauze, or, if large, grasped with the forceps (Fig. 90) and cut away. The finger-tip should be inserted into each posterior naris and every pains taken to detect little shreds of adenoid tissue that have escaped the curette because of their anterior position, and, which if allowed to remain, will greatly impair the success of the operation. In aural cases the surroundings of the 204 DISEASES OF THE NOSE, THROAT, AND EAR Eustachian prominences should receive especial attention, and masses of adenoid tissue still remaining in Rosenmuller's fossae should be carefully rubbed away with the finger-tip or re- moved with the forceps. Some operators prefer to remove the entire adenoid mass with forceps, which are introduced closed behind the soft palate. The biting tips are then opened and forced upward against the vault of the pharynx, the handles brought into contact with the patient's upper teeth, the blades pushed backward against the posterior wall of the pharynx and closed about the growth, which is removed with a downward and outward pull. The forceps can be reintroduced as often as necessary to remove the entire mass, but it is important that the handles should be kept in contact with the patient's upper teeth, for the curve of the forceps is such that otherwise the posterior edge of the septum will be grasped. When operating under ether the foot of the operating table should be elevated about 3 inches and the patient should lie upon his left side with the arm and the shoulder of that side drawn behind and under him, so that the head readily can be rotated downward in order that the blood may flow from the mouth and not enter the larynx. Ordinarily pools of blood and clots collect in the hollow of the left cheek, which requires mopping out, especially if the tonsils have been excised pre- liminary to the removal of the adenoids. From the third tonsil most of the hemorrhage escapes from the nasal passages, and for a moment is abundant, but quickly subsides. Should this not be the case, a small gauze sponge in the grasp of a curved hemostat should be passed up behind the palate and pressure maintained upon the bleeding spot until the hemor- rhage ceases. Under ether cutting forceps are much safer than an operation with the ordinary curette, because the portions of tissue severed by the forceps are removed in the grasp of the instrument, so that they cannot be inspired into the larynx. However, good operators, in their desire to do a "thorough" operation, have DISEASES OF THE NASOPHARYNX 205 bitten off with the forceps portions of the posterior edge of the vomer or even of the soft palate, and it is safer, unless the operator has great experience, not to introduce the forceps unless guided by the forefinger of the left hand, inserted behind the palate, so that he may be certain that neither the posterior edge of the vomer, the soft palate, nor one of the Eustachian tube mouths enter between the cutting blades of the forceps, and the operation should not be so "thorough" as to expose the fibrous tissue overlying the vertebra or tear loose a portion of the upper border of the superior constrictor of the pharynx. It is a good plan to insert the left forefinger into each choanae and strip the adenoid mass downward and back- ward from the pharynx so as not to leave a fringe of its upper border when the operation is complete. The improvement in nasal respiration and in pronunciation following the operation is immediate and pronounced; and if hearing was impaired as the result of interference with the function of the Eustachian tubes, the acuteness of hearing rapidly improves after the operation. In adults the reaction from the operation is but trifling. However, children some- times complain for a few days that the throat is sore and that it hurts them to swallow. Sometimes a considerable time elapses after the operation before a young child can be taught to breathe entirely through his nose. Of course, in cases where mouth breathing is the result of other causes than adenoids, removal of the third tonsil does not secure nasal respiration, and before resorting to an operation, which may be unnecessary, the surgeon should bring about a cure of any nasal catarrh that is present. In cases where, as a result of a faulty position of the teeth or malformation of the jaws, the lips do not come together when the child's face is at rest, it will be necessary to correct the dental deformity as well as remove adenoids to secure nasal respiration and a symmetric development of the bones of the face. In individuals between five and twenty-five years of age, if there is a fair amount of nasal respiration, the faulty 206 DISEASES OE THE NOSE, THROAT, AND EAR position of the teeth should be corrected before any nasal operation is undertaken, but if nasal respiration is greatly impaired, operations on the air-passages sufficient to secure nasal breathing should be done before regulating the teeth. Thomwaldt's Disease or Chronic Bursitis.-The bursa of the pharyngeal tonsil was described by Luschka, and chronic inflammation of this structure was later elucidated by Thorn- waldt, after whom the disease has been named. Symptoms.-When chronically inflamed the bursa of the third tonsil secretes a considerable amount of thick, tenacious mucus, globular masses of which may be hawked out by the patient from the pharynx several times a day. There are no other subjective symptoms in uncomplicated cases. The bursa is discernible and may be explored to a variable depth by means of a probe suitably bent. Treatment.-The concensus of opinion seems to be that a per- manent cure can only by effected by the radical destruction of the bursa by means of the galvanocautery or some other method, a difficult matter to accomplish because of the anatomic situation of the bursa. However, almost complete cessation of the discharge, for the time being at least, can be brought about by thorough cleansing of the parts and applica- tions to the interior of the bursa, by means of a cotton-tipped probe, of a 12 per cent, solution of nitrate of silver at suffi- ciently frequent intervals. DISEASES OF THE OROPHARYNX Acute tonsillitis is an inflammation of the tonsils and adjacent structures. There are two common varieties-the croupous and the phlegmonous. Acute follicular tonsillitis or croupous tonsillitis is an in- flammation of the tonsil, originating in the crypts and accom- panied by the formation of a pseudomembrane which, at first confined to the neighborhood of the crypts, often ex- tends over the entire tonsil or tonsils. Occasionally the DISEASES OF THE OROPHARYNX 207 pharyngeal or lingual tonsils are involved or the disease may occur in these structures independently. Etiology.-The disease is the result of infection, but is conta- gious only to a very limited degree. It is an inoculation of the tonsils with bacteria capable of producing a croupous pseudo- membrane, the most common of such bacteria being the strep- tococcus and staphylococcus. Probably exposure to cold and an excess of uric acid in the blood are predisposing causes. Occasionally cases of croupous tonsillitis are followed within a month by acute articular rheumatism, and it is mantaind that the tonsils are the points at which the bacteria causing the rheumatism find entrance into the system. Fig. 93.-Crypts in cases of tonsillitis: A, Acute, lacunar; B, hronctc hypertrophic; a, surface epithelium; b, accumulated con- tents of crypt; c, lymphoid fol- licles surrounding crypt. (Kauf- mann.) Fig. 92.-Follicular tonsillitis. Pathology.-The brunt of the inflammation is borne by the crypts of the tonsils, which pour out an abundant fibrinous secretion, which, adhering to the surface of the tonsil, presents somewhat the appearance of a diphtheritic membrane (Figs. 92 and 93). The membrane consists largely of necrotic epi- thelial cells, and does not involve the deeper tissues. The tonsils are somewhat swollen and the entire pharynx is inflamed. Diagnosis.-In typic cases occurring in adults there is usually no difficulty in distinguishing by the unaided eye the differ- ence between such a membrane and the more yellow, thicker, and sometimes seminecrotic membrane of diphtheria. The 208 DISEASES OF THE NOSE, THROAT, AND EAR croupous membrane is thin, white, perhaps opalescent, and can somewhat readily be wiped away, a small piece at a time, by means of a cotton-tipped probe. Ordinarily it does not extend beyond the tonsils. However, in the case of young children, diagnosis by the unaided eye between the two affections is by no means easy. The struggles of the child allow only a momentary glance at the parts, and for the same reason some bleeding may occur in the effort to remove a part of the membrane. Occasionally a thin opalescent patch occurs upon the anterior pillars or elsewhere in the neighborhood of the tonsil, whose appearance is very deceptive. In no case can an absolutely positive diagnosis between croup- ous tonsillitis and diphtheria be made without the aid of a competent bacteriologist, whose investigations shall not only consist of the examination of smears and culture tests, but also inoculation experiments, to exclude Hoffman's bacillus, which closely resembles in all respects, except virulence, the Klebs- Loffler bacillus. Mucous patches upon the tonsils and the superficial ulcer of tertiary syphilis have sometimes been mistaken for croupous tonsillitis, but ordinarily the diagnosis is easy. Symptoms.-There is often a chill, then dryness and stiffness in the throat, soon followed by dysphagia. There is tender- ness on pressure over the lymphatics of the neck, which may be somewhat swollen, but never to the extent seen in diphtheria. Ordinarily the temperature is higher in croupous or fol- licular tonsillitis than in diphtheria, but some cases, after a temperature of 103° F. or thereabouts for the first twenty- four hours, assume the characteristic lower temperature of mild diphtheria. Rare in the adult, at least a croupy cough is to be expected in young children with follicular tonsillitis, and sufficient laryngeal stenosis to require intubation is not impossible. Typical cases run a course of about five days and end in recovery. DISEASES OF THE OROPHARYNX 209 Treatment.-In the case of adults the writer has aborted follicular tonsillitis by the following method: Each affected crypt was in turn washed out with hydrogen peroxid, by means of a Blake's middle-ear cannula screwed on to a hypo- dermic syringe. The curved tip of the cannula employed is about | inch in length and capable of reaching to the bottom of the follicle. Only a drop or two of the peroxid is injected at one time, but the process is repeated until all of the exudate has disappeared. A fine Allen's probe with a few fibers of cotton wrapped about its end is then bent to an appropriate angle, and, after being dipped into a 12 per cent, solution of nitrate of silver, is carried to the bottom of a follicle, and the process repeated until each of the affected crypts has received the silver solution. The surface of the tonsil is then painted with the same solution. The treatment is followed imme- diately by a sense of relief and comfort, and the difficulty in swallowing is in a great measure alleviated. The process may be repeated two or three times a day, and in successful cases brings about a cure at the end of the second or third day. In cases of children or in adults, when as the result of ti- midity or excessive irritability of the fauces this method is not applicable, spraying the parts with hydrogen peroxid and the application of a 12 per cent, solution of nitrate of silver suffices for the local treatment. A 12 per cent, solution of silver care- fully applied to the tonsils occasions little or no discomfort in health, and when the mucous membrane of this region is inflamed the solution acts as a sedative and its application is followed by a sense of relief and comfort. This, however, is by no means true of the mucous membrane covering the pos- terior wall of the pharynx, and care should be exercised not to irritate it by the application of the silver solution. The patients if seen early in the attack should be purged, preferably with calomel; and if the temperature is high and the discomfort great, relief follows drop doses of tincture of aconite every hour for six or eight hours. A simple astringent gargle 210 DISEASES OF THE NOSE, THROAT, AND EAR or a lozenge of guaiac and tannin may be prescribed (Formula 64), or the patient may spray his throat every hour with a solution of alumnol. Keefer treated 60 cases in the military hospital at Fort Russell, Wyoming, by spraying the throat with a saturated solution of sodium bicarbonate three times a day, immediately followed by the liberal application of finely powdered acetyl salicylic acid (aspirin). The results were that the tonsils became blanched and the patients entirely comfortable within twenty hours, with an average duration for the disease of three days. No case so treated was followed by articular rheumatism. In another series of 6c cases treated by the usual methods the average duration of the disease was Fig. 94.-Posterior view of the extirpated tonsil from a case of chronic follicular tonsillitis. Bristles have been introduced into the follicles (Fruhwald.) six days, and 9 cases (15 per cent.) developed subsequently acute articular rheumatism. No cases were apparently benefited by aspirin internally. Chronic follicular tonsillitis is characterized by a feeling of fulness and discomfort in the region of the tonsils. Upon inspection the tonsils, although not hypertrophied, are perhaps redder than normal, and many of the crypts are filled with a cheesy exudate (Figs. 92 and 94). The neighboring lym- phatics are generally enlarged and tender to the touch. Treatment.-The cheesy exudate should be carefully removed from the crypts, and a solution of iodin (Formula 112) applied to the interior of each crypt by means of a few shreds of absorbent cotton wrapped about the end of a fine probe which DISEASES OF THE OROPHARYNX 211 is bent to a right angle. Should biweekly applications of iodin in this manner to the interior of the crypts not prove successful, a fine galvanocautery-knife should be inserted while cold into such of the crypts as resist treatment, and while in situ sufficiently heated to destroy the secreting surfaces and burn through the tissues to the surface. In cases where the crypts are very deep, cutting through to the surface of the tonsil is a somewhat painful procedure, and a tonsil crypt knife had better be used for the purpose, after which the wound Fig. 95.-Hurd's separator and pillar retractor. should be seared with the galvanocautery to prevent its re- uniting during the healing process. The cheesy secretions are readily removed by means of a syringe (Fig. 29, fitted with nozzles 6 and 7). After the crypts have been thoroughly cleansed, iodin solution or 10 per cent, nitrate of silver may be applied, as described above. This treatment is frequently sufficient to prevent the formation of tonsillar concretions or Fig. 96.-Myles' tonsil knife. cholesteatoma and the recurrent attack of peritonsillar abscess. However, treatment is tedious and the result somewhat un- certain, so that the trend of opinion at the present time is toward the complete removal (see Tonsillectomy) of tonsils with diseased crypts. Peritonsillar abscess is sometimes apparently the result of exposure to cold and wet. Recurrent attacks of periton- sillitis often occur in chronic inflammation of the tonsils, 212 DISEASES OF THE NOSE, THROAT, AND EAR with or without hypertrophy. The cheesy secretion that is retained within the crypts becomes from time to time a source of infection, and inoculates either the tonsillar structure itself or, more frequently, the surrounding cellular tissue. For these reasons, tonsillotomy or partial excision of hyper- trophied tonsils is not always followed by a cessation of re- current attacks of quinsy, unless, after excision, care is taken to destroy with the galvanocautery-knife all crypts that may remain in the stump of the tonsil, in order to destroy all re- ceptacles capable of retaining putrid secretions. Symptoms.-There is a chill or chilly sensations, and pain in the legs and back, headache, and fever which may reach 1040 F. As the disease progresses the sufferings of the patient become severe. The dryness of the throat causes frequent attempts at swallowing saliva, which are exceedingly painful. The mouth can be opened only with pain and difficulty and speech becomes almost unintelligible. The tongue is heavily coated and the breath intolerably fetid. The hearing is frequently blunted from extension of the disease to the Eus- tachian tubes, and abscess of the ear sometimes results, while nasal breathing is usually entirely abolished. The fever, pain, and difficulty of swallowing become greater if an abscess is forming, and the relief is proportionate after it has opened. As the patient expectorates the pus he feels almost well, so great is the sense of relief, the fever and pain subsiding together. Treatment.-A thorough application of a 12 per cent, solu- tion of nitrate of silver frequently aborts the attack if applied early and the inflammation is superficial. The silver solution should be freely painted upon the tonsils and adjacent inflamed mucous membrane by means of a swab of cotton. The relief experienced by the patient as the result of the application is almost instantaneous, and the application should be repeated once or twice a day until all inflammatory symptoms have subsided. If the inflammation is not too severe the crypts may be syringed with an alkaline solution in the expectation of DISEASES OF THE OROPHARYNX 213 removing putrid retained secretions which may have caused the attack. The nares and pharynx should be washed by means of a spray from an atomizer containing a detergent solution (Formulas i to 5) before making these applications. It is best to open the patient's bowels thoroughly at the com- mencement of an attack by means of a saline cathartic. When these measures do not succeed in aborting the attack, but the fever and the suffering of the patient are constantly increasing, aconite in drop doses of the tincture every hour or two until eight to ten doses have been taken will give most excellent results. When pus has formed the abscess should be opened. The surgeon should carefully search for fluctuation by means of his forefinger introduced into the patient's mouth. As the abscess isj almost always peritonsillar, a fluctuating area is most commonly felt through the anterior pillar above the tonsil. Into this place, the so-called point of election (Fig. 97), a small bistoury should be care- fully thrust with the blade ver- tical, in order to avoid cutting any large vessel that may occupy an anomalous position in this region. If a sudden secession of resistance indicates that an abscess-cavity has been penetrated, the blades of a pair of angular scissors or for- ceps should be introduced and the puncture stretched open until the pus has escaped. If necessary the opening may be enlarged by cutting downward with a probe-pointed knife. The cavity may then be washed out with sterile water. The escape of pus is followed by immediate and great relief and all symptoms usually quickly subside. Even when no pus escapes Fig. 97.-Phlegmonous tonsil- litis. The black line represents the so-called point of election for puncturing a peritonsillar ab- scess, but it is not high enough, as the incision is made through the palate and not into the tonsil. 214 DISEASES OF THE NOSE, THROAT, AND EAR from the incision, the bleeding affords a certain amount of re- lief and may bring about resolution of the inflammation. Frequently a peritonsillar abscess may be opened with a strabismus hook or a stout steel probe of similar shape. The tip of the instrument is inserted into the supratonsillar fossa as deeply as possible, and an effort made to enter one of the vertical crypts or insert the probe between the tonsil and the anterior pillar. When this is accomplished pus will sometimes well out alongside the instrument. Generally the escape of pus is sufficient to bring about a cure, but in some cases it is necessary to maintain the opening by the daily passage of a probe. Newcomb has collected from medical literature 51 well authenticated cases of severe hemorrhage, with 28 deaths following the spontaneous or operative opening of peritonsillar abscesses, apparently the result of the sudden removal of pressure from an artery involved by the suppura- tion. While in post tonsillectomy hemorrhages it is usually sufficient to ligate the external carotid below the origin of the ascending pharyngeal and as close to the bifurcation as possible, severe hemorrhage following a suppurative process generally requires ligation of the common carotid. Cyst of the Tonsil.-Occasionally the tonsil becomes the seat of cystic disease. Usually the cyst is small in size, but some- times it may be of sufficient capacity to contain | dram of milky fluid, or the contents of the cyst may be of cheesy consistency. Treatment.-'The anterior wall of the cyst should be excised and its interior painted with saturated tincture of iodin or Battey's solution (Formula 29). Hypertrophy of the Tonsils.-'There are four varieties of chronic hypertrophy of the tonsils: First, the ordinary soft hypertrophy of the tonsils found in children and young adults; second, the so-called ragged tonsil; third, the scirrhous or hard tonsil, characterized by an enormous increase of the connective tissue of the gland and a canalicularization of its blood-vessels; fourth, the submerged or buried tonsil, where DISEASES OF THE OROPHARYNX 215 the hypertrophied tonsil does not project beyond the faucial pillars. Symptoms.-There is generally more or less obstruction to breathing, the patient snoring during sleep. The articulation is thick and there may be some difficulty in swallowing, especially in the cases of young children. The crypts of the tonsil may become filled with cheesy masses, which, under- going putrefaction, imparts to the breath an offensive odor. Hypertrophied tonsils also sometimes interfere with the proper performance of the functions of the Eus- tachian tubes and thus are the cause of aural catarrh and deafness. Treatment. - Tonsillectomy, tonsillot- omy, or the treatment of diseased crypts with the galvanocautery. Galvanopuncture is performed in the following manner: A small galvanocau- tery-knife is introduced (cold) into one of the crypts of the tonsils and, being heated while in situ, is made to burn its way out. Two or three such burns may be made at a sit- ting, and will be followed by considerable shrinking of the hy- pertrophied gland. But one of the tonsils should be operated upon with the galvanocautery at any one time, and from five to fifteen such operations are required to reduce the gland to satisfactory dimensions. Galvanopuncture is useful to destroy any diseased crypts that may remain after tonsillotomy. Sometimes in the case of bleeders and others it is desirable to remove a small tonsil piecemeal. For this purpose the tonsil punch (Fig. 98) may be used. Such instruments are useful also in removing shreds of tissue that may remain after an operation with the tonsillo- tome or snare. Tonsillotomy with the tonsillotome is performed as follows: The patient, if a child, should be seated in the lap of an assist- ant, who holds the child's legs between his own to prevent Fig. 98.-Myles' tonsil punches. 2l6 DISEASES OE THE NOSE, THROAT, AND EAR struggling. The assistant then passes his arms under the child's arms and grasps the child's forehead with his two hands so as to control the movements of the child's head. When the assistant elevates his elbows the child's arms are extended in such a manner as to prevent the child reaching his face with his hands and interfering with the operation. The tonsillotome is introduced into the child's mouth flat- wise, like a tongue-depressor, and serves to hold down the root of the tongue and afford a good view of the lower border of the tonsil. The ring of the tonsillotome is now passed around the tonsil from below in order to be sure that the lower border of the tonsil is encircled by the ring, which is pressed firmly Fig. 99.-Ermold's tonsillotome. against the wall of the pharynx. The blades of the instrument are now closed and tonsillotome and tonsil removed together from the mouth. If the operator is provided with two tonsil- lotomes it is generally feasible to remove the second tonsil before releasing the child, unless bleeding is so great as to interfere with a view of the fauces. The operator should be provided with a set of at least three sizes of tonsillotomes, in order that he may select one with a ring of just sufficient size to snugly fit around the tonsil to be removed. After encircling the tonsil the instrument should be closed somewhat deliberately, and the operator should be careful to make no effort to remove the tonsillotome from the mouth until the tonsil has been completely severed. The operation is not especially painful, and probably causes less discomfort to the patient than the administration of ether. However, there is no objection to administering ether for ton- DISEASES OF THE OROPHARYNX 217 sillotomy. Under such circumstances the tonsils are removed with the child lying on its side and its head turned to one side, with the foot of the operating table elevated about 3 inches, as previously described for the removal of adenoids (p. 204). Tonsillectomy, or the complete removal of the tonsil, in con- tradistinction to tonsillotomy, or the removal of that portion of the tonsil projecting beyond the pillars of the fauces, is advocated by the larger proportion of laryngologists. Tonsil- lectomy is always advisable in submerged tonsils and in small tonsils with diseased crypts. Tonsillectomy can be done on docile adults after the injection of local anesthetics into the tissues about the tonsils (Formula 11), but it is better under- taken under etherization. The position of the patient on his side and the elevation of the operating table is the same as for the removal of adenoids. A mouth gag in inserted, the tongue is held down and forward with a depressor; mucus and saliva are removed from the pharynx with a gauze sponge; the tonsil is grasped with stout volsellum forceps provided with a catch to render them self- retaining. The upper blade of the instrument should be in the supratonsillar fossa and the lower inserted into the lower border of the tonsil in such a manner that a part of the capsule and so considerable a portion of the tonsil is included within the grasp of the forceps that they will not readily tear out. The tonsil is now pulled strongly toward the median line of the pharynx, so that its extent beneath the anterior pillars is readily seen. While traction toward the median line is maintained, the anterior and posterior pillars are dissected loose from the tonsil by means of the tonsil knife (Fig. 96), the tonsil being rotated downward and inward out of its bed or pushed or pulled away from the pillars to facilitate the procedure. Especial attention is directed to the attachment of the tonsil to the anterior pillar at the point where the plica triangularis leaves the anterior pillar to extend backward over the lower third of the tonsils. The capsule of the tonsil extends forward and medianly to attach itself to the edge of the anterior pillar at 2l8 DISEASES OF THE NOSE, THROAT, AND EAR this point, and hence, severing this attachment, opens up the space behind the capsule and permits the tonsil to sag outward from its fossa toward the median line of the pharynx. The tonsil is attached now only by its lateral portion to its bed, from which it can be still further enucleated by the use of the finger-tip inserted into the supratonsillar fossa, better with Hurd's enucleator, a stout steel curette, slightly curved at the tip, which is about the size but much thicker than the fore- finger-nail (Fig. 95). The loop of a snare (Fig. 100) is now slipped over the forceps and made to surround the base of the tonsil, which by the use of the enucleator and finger-tip has become pedunculated and adherent only at its inferior portion. Fig. ioo.-Martin's tonsil snare. This is one of the best of the tonsil snares that can be used readily with one hand. Tyding's snare, although larger and more clumsy, removes the tonsil as quickly as a tonsillotome, and hence is cer- tainly the preferable instrument when operating without general anesthesia. As soon as the tonsil is enucleated its fossa should be filled with a small gauze sponge, either held in long curved tonsillar hemostats or placed in position and firm pressure maintained with the fingers. After a few moments the wound should be inspected. Frequently it will be nearly dry or oozing at only a few points, which can be clamped with tonsillar hemostats or disregarded until the other tonsil has been removed, by which time the wound may have become entirely dry. When the patient is lying on the left side 'the left or lower tonsil is re- moved first, then the right or upper tonsil, and finally adenoids if present. In some cases it is difficult to at once grasp a sufficiently large portion of the tonsil to prevent the forceps tearing out when firm traction is made, especially when some of the tough fibers of the capsule are not within the grasp of the forceps. Under such circumstances, it may be desirable to draw the tonsil out of its bed toward the middle line of the pharynx DISEASES OF THE OROPHARYNX 219 before applying the forceps. Tenaculum forceps of many patterns have been devised by operators: some with four prongs, some with six and some with even eight. The author's preference is for a small four-pronged instrument bent laterally near the tip; in fact the familiar double tenaculum forceps used by surgeons during the past half century or more, whether or not it is provided with a catch is a matter of com- plete indifference, but its small size is a decided advantage over the larger six- or eight-pronged instruments. It is con- venient for the operator to be provided with several tenaculum forceps, so that if one shows a tendency to tear loose another can be applied further back through the capsule of the tonsil. The entire operation can be done with forceps and Hurd's enucleator or some similar instrument or even with forceps and the finger-tips. The objection to this procedure is the unnecessary traumatism and shock occasioned by the rough handling of the parts. It is far preferable to cut the small amount of cellular tissue binding the anterior and posterior pillars to the sides of the tonsils with a shark-knife thus making a smooth cut through the mucous membrane and preserving as much of it as possible. The hemorrhage is so trifling that the parts are easily in view until the base of the tonsils is reached. Then when Hurd's enucleator is pushed underneath the tonsil it serves to lift the tonsil and prevent the necessity of very hard traction with the forceps. It is sufficiently blunt to prevent much hemorrhage; not more than enough blood to stain a few sponges being usually lost unless the foot of the operating table is raised sufficiently to cause congestion of the pharynx. The attachment of the lower pole of the tonsil is often thick and tough and while it can be torn through with the finger or an enucleator, it is better to cut it with scissors or a snare. For this purpose any snare large enough to carry No. 9 piano wire will answer and the more quickly the loop can be closed the better. Before tightening the loop the parts should be inspected to see that the uvula is not included, 220 DISEASES OF THE NOSE, THROAT, AND EAR which might occur if there is considerable oozing of blood. If there is any difficulty in keeping it out of the way it should be grasped by its tip with a small hemostat, which will effectu- ally prevent its being included in the loop. Open wounds of the pharynx heal more quickly if let alone; especially when retching, gagging and increased irritation result from medication of the wound. Frequently a superficial slough presents somewhat the appearance of a pseudomem- brane; but is without significance as far as healing is concerned. However cases of sepsis severe enough to endanger life, and thrombosis of the internal jugular extending upward into the cavernous sinus have been reported. The patient should remain in bed for a day or so, or until the temperature is normal, and subsist on a soft diet until the soreness of the parts subsides sufficiently to permit the swallowing of more solid food. If the wound is not doing well, it may be touched with a 12 per cent, solution of silver nitrate or dusted by means of a powder-blower with a powder of iodoform, tannic acid, and bismuth (Formula 119), which will closely adhere to the wound and remain in contact with it for a long time. Occasionally operations on the tonsil are followed by danger- ous hemorrhage. This generally occurs at the time of the operation or some hours after the patient is thoroughly recovered from the ether. Before operating the pharynx should be carefully inspected for anomalous arteries and the region of the tonsil palpated to detect any unusual pulsations. Resident physicians in hospitals should be trained in the methods of controlling hemorrhage after tonsil operations and nurses should be instructed to inspect a child from time to time after a tonsillectomy to be assured that the child is not swallowing blood; for when hemorrhage occurs some hours after the operation in young children, the blood is usually swallowed; so that the first symptom of danger may be the vomiting of a large quantity of blood, rapidly followed by collapse. Under such circumstances, a tonsil clamp may be useful in controlling the hemorrhage until more effective DISEASES OF THE OROPHARYNX 221 measures can be instituted. The clamp can be applied either alone or over a gauze sponge inserted into the tonsillar fossa. However no clamp is as effective in controlling hemor- rhage as digital pressure through a gauze sponge on the bleeding tissues. The pressure should be continued for a few moments, the sponge then gently removed and the parts inspected. It is possible that all parts of the wound will be found apparently oozing blood. Under such circumstances, the sponge should be moistened with peroxide of hydrogen, inserted into the tonsillar fossa and pressure again applied upon the removal of this second sponge, the hemorrhage will be manifestly less and probably will be controlled by painting the parts with dilute Monsell's solution. Possibly one or more points will still continue to bleed and to these the undiluted Monsell's solution should be applied by means of a cotton-tipped appli- cator held firmly upon the bleeding point. Monsell's solution is an irritant and the undiluted solution should be used with care that no excess of the solution trickles down the pharynx into the larynx. After the oozing of blood from one tonsil is controlled, the other should be treated in the same manner and if blood is seen flowing from the adenoid wound behind the palate, dilute Monsell's solution should be painted upon this wound also by means of a bent cotton-tipped applicator. If the removal of a tonsil is followed by profuse hemorrhage, it should be controlled by inserting one or more sponges into the tonsillar fossa and making firm digital pressure. After a few moments, the sponges are cautiously withdrawn in such a manner that one part after another of the wound is exposed so that any spurting artery can be seized by long Kocher hemostats and tied. If at the first attempt the vessel is not seized, a slight twist upon the instrument will probably control the hemorrhage sufficiently to enable the operator to see the bleeding spot more distinctly and clamp it with a second pair of hemostats. Small spurting arteries give no especial trouble except that it is a little more awkward to tie them than in a superficial wound. Occasionally a vessel upon the inner 222 DISEASES OF THE NOSE, THROAT, AND EAR surface of the anterior pillar will bleed in such a manner as to momentarily confuse the operator; because when the pillar is drawn forward the pressure will be sufficient to control the hemorrhage, which recurs immediately the pillar is released. However, if the anterior edge of the pillar is seized with forceps in such a manner that its cut posterior surface can be inspected, the bleeding vessel is easily found and tied. Hemorrhage after the removal of adenoids may be so severe as to require a postnasal plug of iodoform gauze in order to control it, which is inserted in the manner already described, for the control of nasal hemorrhage. Occasionally after the removal of adenoids and tonsils patients recover from their ether very unsatisfactorily and for a long time remain nearly pulseless with shallow respiration. The extremities are cold and the little patient although conscious is aroused with difficulty to answer questions. Such symptoms occur sometimes in children who are fairly robust and who have not received an inordinate amount of ether nor lost a large amount of blood at the operation. Fatal cases of this character have been attributed to the presence of a thymus gland that has not undergone spontaneous metamorphosis and partial absorption, the so-called 1 'habitus lymphaticus." It is probable that in some of the fatal cases reported, the element of surgical shock must have played an important role; and that it is always safest to subject the tissues of the pharynx to as little rough handling as possible during tonsillectomies and as little blunt dissection as is compatible with safety from hemorrhage. If during the operation the use of the tongue depressor caused the patient's respiration to cease, pressure should be relaxed until the respirations become normal. If necessary, the tongue should be drawn out of the mouth with volsellum forceps and pressure applied to only that portion of its base necessary to display the tonsil. In some cases embarrassed respiration becomes very much improved after the removal of the first tonsil. No more ether should be used than is necessary to produce relaxation of the pharyn- DISEASES OF THE OROPHARYNX 223 geal muscles and it should be remembered that the pharyn- geal reflex is one of the last to disappear under ether. There should be no more hemorrhage than is unavoidable and the surgeon or his assistant should take the time and pains to stop practically all bleeding after one tonsil is removed before removing the other. Lowering the head more than is just sufficient to prevent blood gravitating into the larynx or lower- ing the head by bending the head backward so greatly in- creased the congestion of the pharynx that what is gained by decreased probability of blood reaching the larynx is lost by increased congestion. Consequently there is commonly less hemorrhage with the patient lying on one side, as already described, so that blood gravitates into the hollow of the cheek that when the patient is prone because there is less necessity for greatly lowering the head. If in spite of precautions, the little patient is profoundly shocked by the operation, the foot of the bed should be raised and oxygen administered. The heart's action should be main- tained by heat over the heart and strychnine, and blood pres- sure increased by the use of 8 ounces of normal salt solution by hypodermoclysis and the institution of enteroclysis by the drop method. Sepsis, severe enough to threaten life, deep cervical cellulitis, resulting in abscess, and thrombosis of the internal jugular extending through the lateral sinus into the cavernous with resulting loss of vision in one or both eyes have been reported. Considering the fact that the mouths of children on whom tonsillotomies are done, often contain carious teeth, it is astonishing that such wounds do not oftener become infected. However it is noticeable that infection most often occurs at the hands of those who are most careful of the after treatment of tonsillectomy wounds and it is possible that the gagging and retching and consequent irritation of the wound may invite infection rather than tend to prevent it. The author's routine treatment of tonsillectomy wounds consists of inspection for the first three days. His only case of infection occurred in a 224 DISEASES OF THE NOSE, THROAT, AND EAR young woman with a tubercular history who developed a severe cervical adenitis followed by abscess. A slight hemor- rhage occurred the night following the operation which was controlled by digital pressure and some hours later painting the wound with Monsells' solution. She left the hospital on about the fourth day after the operation, remained for a day or two in a house where there was diphtheria and returned to the hospital with the glands at the angle of the jaw greatly swollen. As there was no pseudomembrane and the diphtheria bacillus was not found and the tonsillectomy wound on the other side of the pharynx healed without incident, it was thought that the handling of the wound necessary to control hemorrhage was probably the main cause of the infection. The lingual tonsil is subject to the same diseases that affect other adenoid structures of the pharynx. Occasionally a Fig. ioi.-Reflex spasms of the glottis, caused by a large hypertrophy of the lingual tonsil (Rice). venous varix occurs at the base of the tongue on and about the lingual tonsil. If its size is a source of irritation the principal veins should be destroyed with the galvanocautery, which, for this purpose, should not be above a dull-red heat or the vein will be opened and hemorrhage occur. The lingual tonsil (Fig. ioi) becomes sufficiently hypertrophied sometimes to cause irritation and reflex cough. Under such circumstances the redundant tissue should be cut away by suitably curved DISEASES OF THE OROPHARYNX 225 scissors with serrated edges to prevent the flabby tissue slip- ping from the blades. Occasionally the so-called lingual goiter is found at the base of the tongue and should not be mis- taken for hypertrophied lingual tonsils. Acute pharyngitis is an acute inflammation of the mucous membrane and underlying structures of the pharynx. Etiology.-Acute pharyngitis is generally the result of ex- posure to wet and cold, especially of persons of the rheumatic diathesis or of debilitated constitutions. It may also result from traumatism or the presence of a foreign body in the pharynx. Slight unilateral pharyngitis is not uncommon after an intranasal operation, and is probably due to a mild infection. It lasts for a day or two and then passes away. Pathology.-The inflammation is usually by no means evenly distributed, the glandular elements being always most affected. Their secretion is at first increased, but becomes after a time decreased, starchy, and glue-like in character. The tonsils are always involved to a greater or less extent. Symptoms.-The constitutional symptoms are usually tri- fling, a feeling of lassitude with slight fever. The throat feels sore, dry, and stiff. The local symptoms may increase until pain, especially when deglutition is attempted, becomes quite severe. The cervical glands are often swollen and painful to the touch. The voice is usually husky and a sensation as of a foreign body in the throat keeps the patient hawking and spitting. When the tonsils or larynx are seriously involved in the inflammation, symptoms are present referable to these organs. Treatment.-A saline cathartic should be administered in sufficient quantities to secure one or more free movements of the bowels. A io per cent, solution of nitrate of silver should be freely painted over the inflamed lateral walls once or twice a day. It is immediately followed by a sensation of relief and comfort, and tends to materially shorten the course of the disease. Applied to the posterior pharyngeal wall solutions of silver nitrate of over i or 2 per cent, produce a sensation 226 DISEASES OF THE NOSE, THROAT, AND EAR of dryness, stiffness, and discomfort, and stronger solutions should not be used. In this region a io per cent, solution of argyrol sprayed upon the parts is preferable to the use of the nitrate. When acute pharyngitis is the result of the presence of a foreign body, it should, of course, be at once removed and the inflamed pharynx treated as ordinary acute pharyngitis. When the rheumatic diathesis exists, the administration of guaiac (Formulas 62 and 63) will be found to yield most ex- cellent results, while in gouty sore throat colchicum should be prescribed. A spray of adrenalin chlorid (1 :10,000) used every hour by the patient quickly relieves the congestion in most cases; but other astringent sprays are sometimes equally efficient, the best probably is alumnol (1 dram to 4 ounces of water). If it is inconvenient for the patient to use an at- omizer, lozenges may be prescribed. The camphomenthol lozenge (Formula 66) is sedative and relieves the feeling of dryness and stiffness by increasing the secretions, and the same may be said of a lozenge of guaiac and potassium iodid. However, one of the most popular lozenges in this condition is that of guaiac and tannic acid (Formula 64). Simple chronic pharyngitis is a chronic inflammation of the mucous membrane of the pharynx, generally the result of chronic rhinitis and accessory sinus disease. The disease is often complicated by inflammation of the follicles of the mucous membrane, and is then called follicular pharyngitis. Treatment.-It is all important to bring about cure of the nasal disease, to the presence of which the pharyngeal malady is due. After a cure of the primary nasal affection has been brought about, simple chronic pharyngitis will get well almost without treatment. During the treatment of the nasal affec- tion, however, applications should be made to the vault of the pharynx of Formulas 112, 113, or 114 in the following manner: A tongue-depressor (Fig. 8) should be used to hold down the tongue and the patient requested to try to breathe through his nose or say "One" in order to relax the palatine muscles, when the application may be made without difficulty by means of DISEASES OF THE OROPHARYNX 227 an applicator, the end of which has been wrapped with cotton and bent to a suitable curve. Should, however, the palate lie closely in contact with the pharyngeal wall, considerable force will be required to carry the end of the applicator into the postnasal space, while most of the solution with which the cotton on the end of the applicator has been saturated will be squeezed out and remain in the fauces. Applications made in such a manner tend rather to increase the existing inflam- mation than to subdue it, and it is always best to desist from making an application to the pharyngeal vault rather than em- ploy force. When the uvula has become elongated or the mucous membrane of the fauces relaxed as the result of con- stant hawking, the daily application of the spray from an atomizer containing a solution of sulphate of copper (2 gr. to an ounce of water) will render material assistance in restoring the "relaxed throat" to a condition of health. In some in- stances it is necessary to amputate redundant mucous mem- brane at the tip of the uvula. Chronic follicular pharyngitis, or clergyman's sore throat, is a chronic pharyngitis characterized by inflamed and hyper- trophied lymph-follicles. The pathology is similar to simple chronic pharyngitis, except that the lymph-follicles are involved in large numbers and to a greater degree. The subdivision of pharyngitis and follicular pharyngitis is a matter of convenience rather than fact, as in all simple inflammations of the pharynx, the mucosa, the lymph- follicles, the submucosa, and often the muscles are usually in- volved in varying degrees. The watery portions of the secre- tions are decreased and hence the expectorations are thick and glue-like from an increased proportion of mucin, epithelium debris, and mineral salts. Etiology.-The disease is generally the result of or part of a nasopharyngeal catarrh, nostrils too wide to efficiently warm and moisten the inspired air, excessive or faulty use of the voice, excessive use of tobacco and distilled liquors, the rheumatic or gouty diathesis, indigestion, and, in women, pelvic diseases. 228 DISEASES OF THE NOSE, THROAT, AND EAR Symptoms.-The secretions are usually somewhat scanty and viscid, but voided with considerable difficulty. There is a short, frequent cough, distressing alike to patient and friends; the so-called "useless cough," because it accomplishes nothing, either in ridding the throat of secretions or the constant phar- yngeal irritation, of which many of these patients complain. The appearance of the pharynx varies somewhat; usually there is a venous hyperemia over the entire surface, but greatest in the neighborhood of patches of hyperplastic follicles. In other cases the pharynx is less congested, the hypertrophied follicles projecting above the surrounding surface and sur- rounded by varicosities. Sometimes a number of inflamed follicles coalesce in such a manner as to form a red, sore, and swollen area of considerable size. If such patches be situated close to the posterior pillars, so that they are rubbed and irri- tated by these folds of mucous membrane with every motion of the pharyngeal muscles, the sufferings of the patient amount to actual pain. Treatment.-The irritability of the mucous membrane cover- ing areas of hypertrophied follicles can be decreased by lightly painting with a 12 per cent, solution of nitrate of silver. However, care should be exercised to prevent the silver solu- tion spreading over the surrounding mucous surface, because strong solutions of silver nitrate are irritating when applied to the posterior wall of the oropharynx. A certain amount of relief is experienced by the use of de- mulcent lozenges, either slippery elm, red gum, camphomenthol (Formula 66), or, better still in many instances, a lozenge of orothoform. Where the so-called useless cough is a prominent symptom, it should be controlled by appropriate doses of sodium bromid. For this purpose as much as 10 to 15 gr. after meals and at bedtime will be required. The matter is of considerable im- portance, as the constant coughing greatly irritates the pharynx and increases the existing inflammation. The condition of the tonsils should be carefully examined. DISEASES OF THE OROPHARYNX 229 Often they are slightly hypertrophied and the crypts contain cholesteatomatous masses. The removal of any concomitant disease of the nasal cavities also will have much to do with the success of the treatment. The hypertrophied follicles can be destroyed by touching one at a time with Battey's solution (Formula 29). With many practitioners the radical destruction of the dis- eased glands by means of the galvanocautery is a favorite method of treatment. A very small cautery-knife should be selected, and great care should be exercised not to burn too deeply, or the resulting scar will cause more trouble than the original disease. It is unwise to apply the galvanocautery- knife to more than two or three hypertrophied follicles at one time, or the treatment may be followed by a somewhat sharp attack of acute pharyngitis. Emil Mayer removes the offending follicles by means of a special curette. By this method of treatment, which is much less painful than the use of the galvanocautery, all the hyper- trophied follicles are removed at a single sitting. Atrophic pharyngitis is an atrophic condition of the mucous membrane and submucous tissue of the pharynx. Etiology.-.Atrophic pharyngitis generally results from the inadequate warming and moistening of inspired air and long contact with the irritating discharges of nasal catarrhs. It frequently exists when atrophic rhinitis is present. A dry condition of the faucial mucous membrane, amounting almost to pharyngitis sicca, is found in all mouth-breathers, but disappears spontaneously as soon as the nose has been rendered sufficiently patulous. Symptoms.-The patient complains of his throat feeling dry and stiff. Upon inspection the mucous membrane of the throat appears light colored, thin, and as if varnished. Fre- quently the mucous membrane is so thin that the outline of each cervical vertebra can be distinguished. Sometimes masses of inspissated mucus, perhaps dark colored from the dust inhaled, and swept into ridges by the motions of the 230 DISEASES OF THE NOSE, THROAT, AND EAR soft palate, are seen adhering to the atrophied mucous membrane. Treatment.-Attention should be mainly directed to the condition of the interior of the nose, because when a cure of the nasal affection has been brought about, the concomitant throat disease will get well almost without treatment. The general health should receive attention and if necessary, tonics should be prescribed, while a sluggish condition of the bowels may indicate the use of saline laxatives. If atrophic rhinitis has caused the affection, plugs of cotton, previously mentioned as useful in atrophic rhinitis, should be made long enough to project somewhat from the posterior nares into the pharynx, while a weak solution of nitrate of silver (gr. v-vx to fgj) should be applied to the atrophied mucous membrane, both above and below the soft palate, to stimulate the atro- phied glands to increased secretion and bring about renewed growth of the atrophied structures. In certain cases it may be advisable to give for a short time some drug like iodid of potassium, phosphorus, or muriate of ammonia to stimulate the pharyngeal secretions. A pill containing gr. of phos- phorus may be given after meals or the lozenge of guaiac and iodid of potassium, one every three or four hours, may be ordered. It should be borne in mind that the stomach does not tolerate well any lengthy administration of these remedies, and in most cases their use is best avoided. Hyperkeratosis or mycosis of the pharynx is a disease in- volving in most cases the faucial, pharyngeal, and lingual tonsils, although other parts of the upper respiratory tract do not always escape. It is characterized by little white, conic elevations, sometimes as large as a grain of rice, due to accu- mulations of horny epithelium extending outward from crypts and follicles, with an admixture of bacteria and sometimes fungi of the mycosis class, most frequently the leptothrix buccalis. Etiology.-Leptothrix is so frequently found in the secretions of the mouth that it might almost be termed a normal constitu- ent. It is especially prevalent in the mouths of individuals DISEASES OF THE OROPHARYNX 231 with carious teeth, accumulations of tartar, etc. Why it should in some individuals cause the horny, chalk-white growths characteristic of mycosis is not well understood, and it is probable that bacteria play an unimportant role in the causation of the disease. Symptoms.-A few cones of keratosis may be present in the pharynx without causing any symptoms whatever. Under such circumstances the masses may be discovered incidentally upon the tonsils while examining the throat. Usually, how- ever, patients with mycosis complain of a tickling sensation in the pharynx and spasmodic cough. Treatment.-On the tonsils and other easily accessible por- tions of the pharynx the little masses should be grasped one by one and pulled off with the smallest size of Farnham's alligator- forceps or, better, Hartmann's ear forceps. After the removal of the little masses the mucous membrane where they grew should be brushed with io per cent, nitrate of silver. In in- accessible localities, like the base of the tongue and beneath the epiglottis, leptothrix is better attacked with a small galvanocautery-knife than the forceps. Some of the cones re-form after their removal. Applications of io per cent, silver nitrate prevents this to a considerable extent, and occasionally when applied to the surface where leptothrix is growing will cause the cones to disappear after frequent applications. Ultimately the growths disappear spontaneously if untreated, the disease running its course in one or two years. Erysipelas of the Pharynx.-Erysipelas of the face some- times extends to the pharynx, or the disease may originate in the pharynx. Etiology.-Like erysipelas elsewhere, the disease is the re- sult of the presence of Fehleisen's erysipelas streptococcus. Pathology.-The fauces are dusky red and swollen. Vesicles form on the surface filled with seropus. The disease is evi- dently contagious under certain circumstances, as epidemics have been described, notably that in America in 1842. Erys- 232 DISEASES OF THE NOSE, THROAT, AND EAR ipelas may extend to the middle ear through the Eustachian tube or to the lungs through the larynx. Prognosis.-In the milder cases the prognosis is good. The phlegmonous variety of the disease is almost invariably fatal. The treatment is that of erysipelas elsewhere. Large doses of the tincture of chlorid of iron (20 to 30 drops in water) should be given every three hours, with strychnin, & gr., if necessary. The nose and pharynx should be sprayed with an alkaline wash every three hours, followed by adrenalin solution (1:1000). The spray of adrenalin should be repeated at in- tervals of a few moments until the parts have somewhat blanched, after which they should be covered with a 20 per cent, solution of argyrol by means of the spray from an atomizer. Phlegmonous pharyngitis is an acute infection of the pharynx phlegmonous in character, extending to the deeper structures and usually terminating fatally in from five to ten days. Etiology.-The disease usually attacks those of broken-down constitutions or the aged. There is usually a history of slight traumatism, followed by virulent infection. Pathology.-There is an enormous swelling of the fauces at an early stage of the disease, followed by a speedy formation of pus, which infiltrates the surrounding tissues and produces pyemia. The organism present in the pus is usually strep- tococci, or there may be a mixed infection. Symptoms.-The onset of the disease is sudden. The tem- perature rises to 1030 or 1040 F. The throat is sore and, as in a case observed by the author at the Philadelphia Hospital, the swelling may be so rapid as to necessitate tracheotomy within twenty-four hours to prevent suffocation. There are. symp- toms of general infection; a clammy perspiration, great weakness and debility, often followed by collapse and death. Treatment.-Local treatment is of little avail. If asphyxia is imminent, tracheotomy should be resorted to; suspected ab- scesses should be opened either externally through the skin by a free incision or in the pharynx if fluctuation is detected. DISEASES OF THE OROPHARYNX 233 Hourly hypodermic injections of antistreptococcus serum should be given, with normal salt solution by the rectum. Nutritive enemas also will be necessary if the patient is unable to swallow, with hypodermics of strychnin gr.) every three or four hours to prevent collapse. Ludwig's angina was first described by Ludwig in 1836 as a severe infection, beginning in the submaxillary region, where it soon assumes a character which he termed "gangrenous in- flammation of the neck." Etiology is so similar to that of phlegmonous pharyngitis that Semon and others have maintained that the diseases were practically identical. There is usually a mixed infection of streptococcus with staphylococci or diplococci. Pathology.-The disease is essentially a rapidly spreading cellulitis, beginning in the region of the submaxillary gland from a point of infection, usually a carious tooth, tonsillitis, or an ulcer in the mouth. Fatal results occur from invasion of the larynx, trachea, and the lungs with general systemic in- fection. It should be borne in mind that any rapidly spread- ing cellulitus of the floor of the mouth is a menace to life be- cause the anatomic conditions favor the early involvement of the larynx; and because of the compression of the inflammatory material between the inner sides of the jaw and under the tongue. Symptoms.-The disease begins as a hard painful swelling in the submaxillary region, which may run a mild course for days and then suddenly assume an alarming character, be- cause the swelling of the parts interferes with respiration and the swallowing of nourishment. Temperature and pulse are often comparatively low, but dyspnea may require trache- otomy within twenty-four hours of the onset of the disease. In most cases septic intoxication is of less moment as a cause of death than the involvement of the respiratory tract, and death may occur even after tracheotomy in syncope and dyspnea in spite of artificial respiration and oxygen. Treatment.-Early incision parallel to the lower border of 234 DISEASES OF THE NOSE, THROAT, AND EAR the jaw over the submaxillary triangle should be done in the expectation of laying bare the focus of infection, which is reached with more certainty in most cases than by the safer median incision beneath the chin above the hyoid bone. In- cisions on the floor of the mouth are rarely successful in liberat- ing pus. When pus is not found in the submaxillary incision the mylohyoid muscle should be divided and the sublingual cellular tissue exposed. Early incision will probably prevent the irregular septic temperature; profuse sweating and delir- ium recorded in some cases. However, after the sublingual tissue has been exposed, should the symptoms indicate, hourly injections of antistreptococcus serum with normal salt solu- tion by the rectum and stimulants should be given, as in the treatment of phlegmonous pharyngitis. Vincent's angina is an infection of the pharyngeal mucous membrane with fusiform bacilli and Spirochaetae which are different forms of the same micro-organism. The disease may be associated with diphtheria, syphilis, or streptococcus or staphylococcus infection. Diagnosis.-The disease differs from an ordinary acute pharyngitis due to streptococcus or staphylococcus infection in the usually less severe constitutional symptoms, the great tendency to ulcerations, and the presence of characteristic organisms. However, Vincent states that in the diphtheroid form of the disease there is simply a membranous inflammation without ulceration and that only fusiform bacilli can be isolated. The symptoms are usually those of subacute pharyngitis, unless mixed infection is present. Headache, general malaise, with a temperature up to 102.50 F., may be present. The breath is foul, the throat painful when swallowing, and there is generally some swelling of the submaxillary glands. The prognosis, where no mixed infection is present, is good, the symptoms abating in three or four days, although some redness of the pharyngeal mucous membrane may persist for many days. In cases of mixed infection the severity of the symptoms depend upon the character of the mixed infection. DISEASES OF THE OROPHARYNX 235 Treatment.-In uncomplicated cases local treatment con- sists in the application of a solution of nitrate of silver (2 to 4 per cent.). The patient should apply to his throat, as a home treatment, the spray from an atomizer containing | to 1 per cent, sulphate of copper. A mild quarantine had per- haps better be observed until the throat clears up. In the more severe forms of mixed infection the internal treatment is similar to that of the phlegmonous pharyngitis. When pseudomembrane or ulcerations are present, the parts should be cleansed and Lbffler's solution applied once or twice a day by means of a cotton-tipped applicator. Neosalvarsan is said to be useful in all diseases in which spirilla play a part. The remedy may be injected as in the treatment of syphilis or a 3 per cent, solution applied to the ulcers and pseudomembrane. Simple Ulcer of the Pharynx.-Most ulcers of the pharynx are either syphilis, epithelioma, or tuberculosis. However, there is an ulceration of the pharynx or fauces, generally the result of mixed infection, that is occasionally observed. Some cases are the result of traumatism followed by infection. The symptoms vary according to the size and location of the ulceration. The pain will be severe, especially during swallow- ing, if the ulceration is so localized as to be irritated by the action of the faucial muscles. Under such circumstances there may be regurgitation of food through the nose. If the in- flammation extends to the larynx there will be hoarseness or loss of voice, and if the tissues about the Eustachian tubes are involved by the inflammation, earache. If the ulceration is long continued there will be a progressive loss of flesh. Upon inspection the ulcer is seen upon the pharynx either medianly or laterally. It may be round or oblong. The edges are usually well defined and the ulcer may be filled with sloughing tissue, or the floor of the ulcer may be comparatively clean and. so deep that when situated medianly the bone of the vertebra is bared. The diagnosis in ulceration of the pharynx rests between syphilitic, tuberculous, epitheliomatous, simple ulceration, and 236 DISEASES OF THE NOSE, THROAT, AND EAR Vincent's angina. The Wassermann reaction test or the administration for a week or ten days of io to 20 gr. of iodid of potassium after meals and at bedtime will clear up the diagnosis as far as syphilis is concerned. Cancer of the pharynx is differentiated by examining micro- scopically a small section removed from the edge of the ulcer, and tuberculosis by the tuberculin-test, the condition of the patient, or by microscopic examination of the sputum. The treatment of syphilitic, epitheliomatous, and tubercular ulcerations has been described elsewhere. In simple ulcera- tion tonics and 10 to 15 gr. of pepsin after meals should be given. The ulcer should be cleansed each day with Dobell's solution or peroxid, and an application made of nitrate of silver (15 per cent.), after which the floor of the ulcer should be dusted either with orthoform or a mixture of iodoform, tannic acid, and bismuth (Formula 120). Both orthoform and the above powder are analgesic and relieve pain. They are also antiseptic and adhere to the ulcerated surface sometimes for hours. Of the two, the iodoform and tannic acid powder gives the better results. Syphilitic pharyngitis is an inflammation of the pharynx due to the presence in the system of the syphilitic poison. The primary sore is not infrequently seen. Mucous patches are by no means rare, while gummata or their characteristic cicatrices are very often met with in the pharynx, especially in dispensary practice. Symptoms.-In primary syphilis, examination shows a whitish abrasion, soon followed by swelling of the glands about the angle of the jaw. Secondary lesions may present either the form of mucous patches or erythema, characterized by a diffuse redness of the entire fauces or, more commonly, in milder attacks, by a broad red line extending upward upon each of the anterior pillars, and ending abruptly and symmetrically at the root of the uvula. Mucous patches and erythematous patches in the throat are almost always symmetric; that is, both sides of the throat are attacked in corresponding localities DISEASES OF THE OROPHARYNX 237 by similar lesions, while tertiary lesions do not as frequently present this symmetry. Gummata more frequently involve the tonsils or soft palate than other parts of the throat. A gumma may be absorbed under treatment or, breaking down, result in a rapidly spreading ulceration. When an ulcerating gumma is situated upon the posterior wall of the pharynx, the cervical vertebrae or even the cervical cord itself may finally become involved, and a fatal issue result. In such cases also the utmost care is required to prevent union of the soft palate and uvula to the pharyngeal wall when the ulceration involves the posterior surface of the palate. Where union has taken place, it is difficult at any subsequent period to permanently restore satisfactory communication between the oropharynx and nasopharynx by any operation because of cicatricial con- traction after the operation. Treatment.-In pharyngeal syphilis, as in syphilis elsewhere, constitutional treatment is of primary importance, and the same remedies may be employed internally as already recom- mended in the treatment of nasal syphilis. If the symptoms are urgent, salvarsan injections should be given. Local treat- ment consists in maintaining perfect cleanliness of the diseased parts and stimulating mucous patches and ulcerations to heal by daily applications of the acid nitrate of mercury diluted with 5 parts of water, and the application, by means of the powder-blower, of a small quantity of Formula 119 or 120. Leprous Pharyngitis.-According to Hoffmann, leprosy of the pharynx begins by the formation of small tubercles, which break down, forming ulcerations which finally penetrate the soft palate, so that in some instances the perforations are so numerous that the palate resembles a sieve. Similar ulcera- tions occur on the pharyngeal wall and the tonsils. In some cases a small ulcer may assume a gangrenous character, associated .with marked systemic toxemia. Under these circumstances, treatment consists in the injection here and there into the gangrenous ulceration of a few drops of a 5 per 238 DISEASES OF THE NOSE, THROAT, AND EAR cent, solution of zinc chlorid, which in a day or two causes a slough which, when separated, exposes clean healthy tissue. The tonsils frequently are the seat of leprous tubercles and become greatly hypertrophied, with subsequent fibroid changes. Tuberculosis.-The presence of the tubercle bacilli is some- times demonstrable by means of the microscope in the secre- tions of a mild chronic pharyngitis of nurses and attendants in the tuberculous wards of hospitals. Primary tuberculous pharyngitis with marked lesions is rare. Secondary tuber- culous pharyngitis in phthisic patients is somewhat common, and is usually observed as ulcerations resembling those of tertiary syphilis. Infection probably reaches the pharynx through some localized solution of continuity from the secretion of the tuberculous lungs. Tubercles form in the submucosa, which finally break down and ulcerate. Treatment.-In cases where there are no marked lung lesions and the diagnosis is obscure, the Wassermann reaction test or antisyphilitic remedies should be administered until the surgeon has satisfied himself that the disease is not syphilis. When ulceration has occurred the ulcers should be cleansed with hydrogen peroxid, cocainized, and touched with lactic acid once in two or three days. As these applications are somewhat painful, even after cocainization, it is well not to employ a stronger solution than 25 per cent, until the amount of pain and reaction caused by the application has been ascertained, after which the concentrated syrupy acid may be employed if deemed advisable. Rarely is it necessary to employ the curette, and the prognosis as regards healing is favorable. Lupus vulgaris is a form of inflammation involving the mucous membrane and submucous tissues of the pharynx, generally ending in ulceration due to the presence of the tubercle bacilli. Etiology.-The disease is said to be more common on the con- DISEASES OF THE OROPHARYNX 239 tinent of Europe than in America. It occurs in tuberculous families and in those frequently brought in contact with tuberculous patients. Symptoms.-'The general condition of the patient may be that of good health. The disease is insidious and causes little annoyance until the ulcers are sufficiently large to interfere with the functions of the parts. Early in the disease soft reddish nodules about the size of sago grains appear on one or both sides of the pharynx. These finally break down, pro- ducing ulcers which may spread to the pillars of the fauces, the palate, or the larynx, one portion of the ulceration healing while another is extending. Pathology.-Portions of the diseased tissue curetted away show, under the microscope, typic giant cells. However, tubercle bacilli are found only in small numbers and with difficulty. Diagnosis.-'The ulcerative stage may be mistaken for herpes, syphilis, or epithelioma. The short duration of herpes and the more rapid progress of epithelioma should serve to differentiate the disease from lupus. . In suspected syphilis the Wassermann reaction or the "therapeutic test"- serves to clear up the diagnosis. The tuberculin-test gives a positive reaction, causing local hyperemia and some rise of temperature, which subsides in twenty-four hours. The micro- scope shows typic tubercle giant cells. Treatment.-The parts should be thoroughly curetted and the solid stick of nitrate of silver applied. Cures have been reported by the use of the rr-ray. Glanders, farcy, or equinia is a contagious, specific disease with both local and constitutional symptoms, usually con- tracted from infected horses. It is due to the presence of the bacillus mallei. Symptoms and Course.-'Pemphigus-like vesicles appear at the point of infection, usually the face. The vesicles ulcerate and the parts sometimes become gangrenous. Metastatic ab- scesses occur on the face, trunk, and extremities. In milder 240 DISEASES OF THE NOSE, THROAT, AND EAR cases vesicles and abscesses heal in a short time and the patient recovers. In severer cases there is marked prostration, with rapid rise in the temperature, headache, pain on swallowing, dryness of the throat, and enlargement of the suxmaxillary and cervical glands. Foul-smelling pus flows from the nose and pharynx and a purulent bronchitis is usually present. The severe form of the disease is usually fatal. Treatment.-Local treatment consists in cleansing the nasal and pharyngeal mucous membranes with diluted hydrogen peroxid and detergent washes and then spraying the nose and pharynx with carbolated albolene. The systemic treatment should be supportive. There is no known specific remedy for the disease. Actinomycosis is a parasitic, infectious, inoculable disease, first observed in cattle and later in man. It is due to the presence of the leptothrix streptothrix, or ray fungus. The most frequent and curable form of the disease is when abscesses form about the jaws or fauces. When the parasite has found a nidus in the lungs or digestive tract the disease is fatal. Etiology.--Actinomycosis is the result of inoculation with the ray fungus, which gains entrance to the mouth, pharynx, or nose from ingesta or inspired air. The disease may originate primarily in either of these cavities and, more rarely, in the larynx or ear. Pathology.-A slow swelling occurs, usually first at the angle of the jaw, which renders swallowing difficult. Upon inspec- tion, if suppuration has not already occurred, the mass will be found to be firm to the touch and involve one or more of the cervical glands or the tonsils. At the seat of infection a nodule occurs which breaks down and discharges pus containing typic granular masses, which, upon compression, form star-like bodies, yellowish in color, with a center which stains blue with Mallory's stain. Symptoms.-The symptoms and pathology of the disease, as affecting the human tonsils, was first described by Jonathan Wright (1904). The symptoms are those of granulating, pain- DISEASES OF THE OROPHARYNX 241 less abscess with general systemic infection. The laryngolo- gist is usually first consulted by the patient for catarrh and hypertrophied tonsils. One or more crypts of the tonsils may be suppurating and lined with granulations. Treatment.-The affected tonsil or tonsils should be ampu- tated. Where this cannot be done, the application of the galvanocautery is the best form of treatment. Each nodule or suppurating crypt should be thoroughly destroyed. Abscesses occurring in localities other than the tonsils should be opened, curetted, and cauterized with the solid stick of nitrate of silver, lodid of potassium in large doses is stated to inhibit the growth of the ray fungus, and Sawyer reports favorably results from the injection into tumors of from 15 to 30 minims of a 1 per cent, solution of the iodid. Retropharyngeal abscess is an abscess of the posterior pharyngeal wall. It may be hidden above and behind the soft palate and require the rhinoscope to ascertain its outline; it may be situated opposite the larynx, and only be seen in its entirety with the laryngoscope, or it may be situated in such a manner as to be hidden by one of the posterior pillars of the pharynx. However, the most common seat of abscess is the posterior wall of the pharynx opposite the oral cavity on one side or the other of the median line. Etiology.-'Abscess may occur as the result of phlegmonous inflammation of the cellular tissue of the pharynx, scroula and syphilis being predisposing causes. Traumatism and necrosis of the vertebrae are sometimes causes of the affection. Symptoms.-'There is usually but slight systemic disturbance. Chilly sensations may perhaps be complained of, but local symptoms are usually the first to attract attention. When the abscess is situated high up upon the pharyngeal wall, a sensa- tion as of a foreign body causes almost constant hawking and spitting, while there may be present obstructed nasal respira- tion with more or less pain and tinnitus. When the abscess is opposite the larynx, dyspnea is a marked symptom, appear- ing in "spasms" which may endanger the patient's life, while 242 DISEASES OF THE NOSE, THROAT, AND EAR swallowing of liquids or solids in dangerous, owing to their frequent passage into the larynx. In the case of an eighteen- months-old child seen in consultation by the writer, the mere attempt to introduce a tongue-depressor into the mouth was followed by collapse and apparent death. The child's life was saved only by a rapid tracheotomy with the only available instrument, a penknife. The next day after the operation the cause of the obstructed respiration was discovered to be a retropharyngeal abscess situated low down in the pharynx opposite the larynx. The abscess was opened and the child made a good recovery. An abscess in the pharyngeal wall opposite the oral cavity presents none of these symptoms unless very large. Treatment.-Left to itself, a retropharyngeal abscess will discharge either into the throat or at some more remote point, but as soon as the diagnosis is established an incision should be made into the abscess at its lowest part, and if required the opening maintained patulous by the daily passage of a probe as long as necessary to bring about a cure of the affection. The author has several times opened a retropharyngeal abscess without general anesthesia with the child in an up- right position. However, it is probably better to place the patient on his side, with the foot of the operating table ele- vated as for a tonsillectomy. The abscess is then located with the forefinger-tip, which serves as a guide for a long-handled knife, and the abscess incised, washed out with boric acid solution, and iodoform emulsion in glycerin injected. When the abscess is complicated by caries of the vertebra it is better opened through the skin by the external route. An incision two or three inches long, is made on a plane with the abscess parallel to the anterior border of the sternocleido-mastoid muscle. The deep cervical fascia is opened and the anterior border of the sternocleido-mastoid muscle exposed and drawn forward. By blunt dissection the carotid sheath with its ves- sels and nerves is separated from the vertebra and drawn for- ward and the dissection carried in front of the vertebra to DISEASES OF THE OROPHARYNX 243 the abscess wall, which is punctured and a closed hemostat inserted and withdrawn opened. The cavity is then explored by the finger for necrosed bone and a drainage-tube inserted. Aneurysm has been mistaken for retropharyngeal abscess with fatal results following incision, so that it is important to arrive at a correct diagnosis before operating. Prognosis is favorable except in those cases where the spinal vertebrae are involved. In all operations upon the posterior wall of the pharynx it should be borne in mind that a large artery is occasionally found in this position, probably the verte- bral, which sometimes enters its osseofibrous canal as high up as the fourth or even second vertebra. It has been seen to leave its canal at the third vertebra, to re-enter it at the atlas. Tumors.-Any of the varieties of tumor found in other parts of the body may occur in the pharynx. They are most fre- quently located in the lateral walls and may involve the sur- rounding structures. In the following order of frequency there is found in the pharynx gumma, sarcoma, carcinoma, lupus, papilloma, cyst, fibroma, osteoma, enchondroma, adenoma, and aneurysm. Symptoms.-When the growth is large it may become an obstruction to deglutition or even respiration. In carcinoma and ulcerating lupus pain is present, which in many instances radiates into the ear. Treatment.-Except in the case of gumma, the treatment of which has been already described, early extirpation with the knife, galvanocautery, or snare should be practised. NEUROSES OF THE PHARYNX The more common neuroses of the pharynx are anesthesia, hyperesthesia, paresthesia, neuralgia, and paralysis, either uni- lateral or complete. Anesthesia is most often the result of hysteria. The pharyn- geal reflexes are abolished; there is a more or less complete loss of pharyngeal sensation when the parts are touched with a 244 DISEASES OF THE NOSE, THROAT, AND EAR cotton-tipped probe. The condition is observed in cases of progressive bulbar paralysis and in the general paralysis of the insane. The treatment depends on the cause of the condition: in hysteria the strong galvanic or induced current with strychnin internally, possibly in increasing doses. Hyperesthesia is generally the result of some disease of the nose and nasopharynx that has rendered the secretions viscid and sticky, so that frequent hawking is necessary to dislodge them. The excessive use of tobacco, especially chewing- tobacco, will produce the condition. In some cases of hyper- esthesia of the pharynx the reflexes are increased to such an extent that barely touching the pharynx is sufficient to produce emesis. There is, of course, hyperesthesia of the pharynx in practically every case of pharyngitis. Treatment.-'Cessation of the excessive use of tobacco or cure of the nasopharyngeal catarrh that has produced the con- dition is ordinarily sufficient to reduce the hyperesthesia to normal and diminish the reflexes. Temporary relief is afforded by the administration of sodium bromid in doses of io or 15 gr. three times a day. When the reflexes are not increased to an extent to produce vomiting whenever the pharynx is sprayed, the patient should spray his pharynx three or four times a day with an atomizer containing a | to 1 per cent, solution of sulphate of copper. Paresthesia is most frequently manifested as a sensation as of a small foreign body in the pharynx. This sensation and burning, itching, or tickling, as well as spasm of the pharyngeal muscles, the well-known "globus hysteriae," are not uncommon in hysteric females. However, in the larger proportion of these so-called hysteric cases some lesion will be found to account for the symptoms if the pharynx be care- fully inspected. The most common lesions are inflamed fol- licles or an erosion on the side of the pharynx, posterior to the posterior pillar, or in any other position where two folds of mucous membrane rub together in deglutition. DISEASES OF THE OROPHARYNX 245 Treatment.-The symptoms are usually quickly relieved by io or 15 gr. of bromid of sodium after meals and at bedtime. After relief has been secured by the use of the bromid, a general tonic treatment should be prescribed for building up the nervous system-rest, iron, quinin, phosphorus. Pil. sumbul comp., one or two after each meal, frequently yields very satisfactory results. When inflamed follicles or any erosion is found in a position where it is irritated by each movement of the pharyngeal muscles, it should be touched every day or two with a 12 per cent, solution of nitrate of silver. Paralysis of the Pharynx.-Etiology.-Paralysis of the pharynx may result from diphtheria or syphilis, or be the result of a cerebral affection involving the nerves that supply the pharyngeal muscles. Transient paralysis of the palate, either unilateral or bilateral, is common as the result of diphtheria; more rarely are the pharyngeal muscles also par- alyzed in severe cases. Pathology.-One or both sides of the pharynx may be in- volved, and one or all three of the pharyngeal constrictors be paralyzed, as well as the vellum palati; but paralysis of the soft palate, either unilateral or bilateral, occurs independently as a "reflex" in ethmoiditis. Symptoms.-Difficult deglutition; liquids being more easily swallowed than solids, but more frequently passing into the larynx; or, when the soft palate is also paralyzed, both solids and fluids may be forced into the posterior nares through the efforts of the tongue to assist deglutition. Treatment.-'The central cause of the affection should be carefully sought and treated. In suitable cases strychnin, in gradually increasing doses until the limit of toleration has been reached, will do good; while arsenic and tonics are especially valuable where the paralysis is of diphtheritic origin. Foreign bodies of two classes are found in the pharynx: First, those whose bulk does not allow them to pass through the esophagus, and second, sharp-pointed objects, like pins, 246 DISEASES OF THE NOSE, THROAT, AND EAR needles, fish-bones, etc., that are forced into the pharyngeal walls by contraction of the constrictor muscles. Symptoms.-Large objects may cause death by holding down the epiglottis. Sharp-pointed objects cause a pricking sensation, sometimes felt at two places in the pharynx, as in the case of a pin or needle. Localized spots of inflammation, when situated low down upon the pharyngeal wall, give rise to the sensation of a foreign body, and this fact, as well as the imaginary foreign body of hysteric women, should be remem- bered after an unsuccessful search for a foreign substance in the pharynx. Treatment.-It is not always possible to use the laryngo- scope to advantage when the foreign body is situated low down in the pharynx, and in such cases the finger should be intro- duced into the pharynx, and if a foreign body be felt an effort should be made to scratch it loose with the finger-nail and withdraw it. When the offending substance can be seen, a pair of forceps, either straight or curved, according to its posi- tion, should be used to withdraw it. It should be remembered that after the removal of a foreign body sometimes a sensa- tion as of its presence remains for some days. DISEASES OF THE UVULA Inflammation of the uvula may occur primarily or as the result of extension of inflammation from the tonsils or palate. Occasionally it becomes edematous. The distention may be so great as to produce dyspnea. The treatment consists in cocainizing the uvula, seizing it with a pair of mouse-tooth forceps, and freely incising the mucous membrane in a number of places in order to allow the fluid to escape. The same object may be accofnplished sometimes more conveniently by snip- ping off the mucous membrane at the tip of the uvula. Pseudomembranous Uvulitis.-'The extension of a pseudo- membrane from the tonsils to the uvula is somewhat character- istic of diphtheria. However, this occurs in other forms of pseudomembranous pharyngitis. DISEASES OF THE OROPHARYNX 247 Treatment of Inflammation of the Uvula.-As inflammation of the uvula generally is only part of an inflammation involving the rest of the fauces, it is best to begin treatment by spraying the fauces with a i : 1000 solution of adrenalin; the uvula should then be painted with a xo per cent, solution of nitrate of silver. This should be done in the physician's office once or twice a day, the patient in the intervals either spraying his fauces every two or three hours with a i : 10,000 solution of adrenalin or a 3 per cent, solution of alumnol. Ulceration of the Uvula.-The uvula sometimes becomes ulcerated as the result of traumatism and infection. Syphilis, lupus, or tuberculosis may be primarily located in the uvula. The uvula is sometimes destroyed by an ulcerating gumma. Occasionally these cases are first seen by the laryngologist when the ulcer has made considerable progress and the uvula hangs, as it were, by a string of mucous membrane. Under these circumstances the uvula sometimes can be saved by the daily subcutaneous injection of bichlorid of mercury (Formula 24), which, although painful, probably yields quicker results than other methods of treatment. Where an increasing gumma involves the posterior wall of the pharynx as well as the uvula and soft palate, there is great danger of cicatricial adhesions occurring that may entirely shut off communication between the posterior naris and oropharynx. Deformities of the Uvula.-Bifid Uvula.-The uvula when present is always bifid in cleft palate as the result of the same cause that produces the palate deformity. Hence, ordinary bifid uvula might be considered as an incomplete cleft palate. The deformity varies from a little dent at the free extremity of the uvula, which is usually club shaped, to a complete division separating the uvula into two lateral halves. Treatment.-Bifid uvula, when it causes no symptoms, is best let alone. However, the parts may be freshened by means of a V-shaped incision and sewed together. If the uvula is thoroughly cocainized and then sprayed with adrenalin, the operation is both painless and bloodless. For anesthetizing 248 DISEASES OF THE NOSE, THROAT, AND EAR the uvula simply painting the parts with a io per cent, solu- tion of cocain is not sufficient. The operator should be pro- vided with a small cup at the end of a long handle. This is partly filled with a 4 per cent, solution of cocain and held under the palate in such a manner that the uvula soaks in the cocain solution for a few moments before the operation. Elongation of the Uvula.-The whole mass of the uvula may be hypertrophied. More frequently, however, merely the mucous membrane is relaxed and hangs as a conic tip be- low the uvula proper. In rare cases a warty growth is at- tached to the end of the elongated uvula. Etiology.-It is generally the result of chronic pharyngitis, the constant hawking to dislodge masses of mucus from the pharynx having a tendency to cause the affection. Paralysis of the palate is a reflex sometimes observed in ethmoiditis, and in such cases paralysis of the azygos uvulae muscles and conse- quent elongation of the uvula are concomitant with the affection. Symptoms.-Patients complain of a "tickling in their throats." The elongated uvula hanging in contact with the base of the tongue causes an almost constant short cough as an effort to dislodge a supposed foreign substance. These efforts are sometimes persisted in until nausea and vomiting result. Snoring is usually marked and the sleep is disturbed by dreams. Treatment.-The redundant portion of the uvula should be amputated. This is ordinarily only relaxed and redundant mucous membrane at the tip of the uvula. It is rarely or never necessary to remove any of the muscular structure of the organ, and amputation of the entire uvula close up to the soft palate is done only for the removal of malignant disease or as the result of the ignorance or awkwardness of the operator. The operation is perhaps best done in the following manner: The uvula is grasped at a point just below where it is decided to amputate with a pair of long hemostats, which are then clamped. The position of the hemostat marks the spot on the uvula where it has been decided to amputate, so that there is DISEASES OF THE OROPHARYNX 249 no danger of cutting off too much or too little. The uvula is stretched well forward and cut off close to the forceps by a single cut of a pair of somewhat heavy scissors, curved upon the flat, and held with their concavity upward in such a manner that the uvula is cut somewhat obliquely upward; and the wound, being upon the posterior surface, is protected from contact with food during the healing process. Generally there is but little inflammatory reaction and the wound heals promptly, but occasionally a mild acute pharyngitis occurs as the result of the operation when the uvula is thick and fleshy. THE LARYNX ANATOMY OF THE LARYNX The larynx is an expansion of the upper portion of the trachea, so that there is formed a musculocartilaginous mem- branous box constituting the essential organ of voice. It lies in front of the pharynx, of which it, with the base of the tongue, forms the lower anterior wall. Its superior aperture slopes downward and backward toward the pharynx and is partly closed from before backward during deglutition by a leaf-shaped lid, the epiglottis. The larynx is connected by ligaments and muscles with the surrounding tissues, the muscles serving to draw it upward during vocalization and deglutition. Cartilages.-The cartilages of the larynx are nine in number, three single and three in pairs: The thyroid, cricoid, and epiglottic cartilages, the arytenoid cartilages, the cartilages of Wrisberg, and those of Santorini. The shapes of these, their relative size, and their manner of articulation and relative position to the hyoid bone are shown in Figs. 102 and 103. The thyroid cartilage, so called from its resemblance in shape to a shield, is composed of two plates or wings, united in front at an angle in such a manner as to project forward beneath the skin of the throat as an elevation-the "Adam's apple." To its outer surface are attached the sternothyroid, thyrohyoid, and inferior constrictor muscles. To its inner surface are attached the epiglottis, the thyro-arytenoid, thyro-epiglot- tidean muscles, and the true and false vocal cords. The superior border of the cartilage curves backward from a median notch to the superior cornua or horns. To this border is attached the thyrohyoid membrane or ligament (Figs. 102, 103). The lower border gives attachment to the cricothyroid membrane 250 ANATOMY OF THE LARYNX 251 or ligament in the median line, and on each side to the crico- thyroid muscles (Fig. 105). The posterior borders and superior and inferior horns give attachment to the stylo- and palato- pharyngeal muscles. To the apices of the superior cornua is attached the thyrohyoid ligament. The inferior cornua articulate with the cricoid cartilage. Fig. 102.-Articulations and ligaments of the larynx, anterior view: A, Hyoid bone, with a its greater, and a' its lesser cornua; 1-5. ligaments; 6, lateral cricoth- yroid articulation; 7, junction of cricoid and trachea (Testut). Fig. 103.-Articulations and ligaments of the larynx, posterior view: A, Hyoid; B, thyroid, with b and b' its cornua; C, cricoid; D, arytenoids; E, cartilages of Santorini; F, epiglottis; G, trachea; 1-6, ligaments; 2, opening for superior laryngeal artery; 7, junction of trachea and cricoid (Testut). Fig. 102 Fig. 103 The cricoid cartilage, so called from its seal-ring shape, lies below the thyroid with its seal or broad surface posteriorly; laterally it articulates with the inferior cornua of the thyroid by means of small articular facets, and on the superior border posteriorly are two other facets for articulation with the arytenoid cartilages. To its lateral surfaces are attached the crico-arytenoideus posticus muscles and the longitudinal fibers 252 DISEASES OF THE NOSE, THROAT, AND EAR of the esophagus (Figs. 104, 105). To its upper border are attached the cricothyroid membrane and the crico-arytenoidei lateralis muscles; to its lower border a fibrous membrane connecting it with the upper ring of the trachea. Fig. 104.-Larynx with its muscles, posterior view:. I, Epiglottis; 2, cushion, 3, aryepiglottic ligament; 4, cartilage of Wrisberg; 5, cartilage of Santorini; 6, oblique arytenoid muscles; 7, transverse arytenoid muscle; 8, posterior crico-arytenoid muscle; 9, inferior cornu of thyroid cartilage; 10, cricoid cartilage; 11, posterior inferior cerato-cricoid ligament; 12, cartilaginous portion; 13, membranous portion of trachea (Stoerk). Fig. 105.-Larynx and its lateral muscles after removal of the left plate of the thyroid cartilage: 1, Thyroid cartilage; 2, thyro-epiglottic muscle; 3, cartilage of Wrisberg; 4, aryepiglottic muscle; 5, cartilage of Santorini; 6, oblique arytenoid muscles; 7, thyro-arytenoid muscle; 8, transverse arytenoid muscle; 9, processus muscularis of arytenoid cartilages; 10, lateral crico-arytenoid muscle; 11, posterior crico-arytenoid muscle; 12, cricothyroid membrane; 13, cricoid cartilage; 14, attach- ment of cricothyroid muscle; 15, articular surface for the inferior cornua of the thyroid cartilage; 16, cricotracheal ligament; 17, cartilages of trachea; 18, mem- branous part of trachea (Stoerk). Fig. 104 Fig. 105 The arytenoid, or "pitcher-shaped" cartilages, articulate with the upper posterior border of the cricoid (Figs. 102-105). To the anterior surface are attached the false vocal cords and thyro-arytenoideus muscles; at the anterior angle or vocal ANATOMY OF THE LARYNX 253 process are attached the true vocal cords and the thyro- arytenoideus muscles. To the posterior surface is attached the arytenoideus muscle. To the posterior angle, or processus muscularis (Fig. 107), are attached the crico-arytenoideus lateralis and posticus muscles (Figs. 104, 105). The median surfaces of the arytenoid cartilages are covered with mucous membrane and face each other; their apices articulate with the cartilages of Santorini. Cartilages of Santorini are two small cartilages at the apices of the arytenoid cartilages, to which are attached the aryteno- epiglottidean folds. Cartilages of Wrisberg are two little masses of cartilage contained in the aryteno-epiglottic folds. Fig. 106.-Diagram to illustrate the thyro-arytenoid muscles; the figure repre- sents a transverse section of the larynx through the bases of the arytenoid carti- lages: Ary, Arytenoid cartilage: p.m, processus muscularis; p.v, processus vocalis; Th, thyroid cartilage; c.v, vocal cords; Oe is placed in the esophagus; m.thy.ar.i, internal thyro-arytenoid muscle; m.thy.ar.e, external thyro-arytenoid muscle; m.lhy.ar.ep, part of the thyro-aryepiglottic muscle, cut more or less transversely; m.ar.t, transverse arytenoid muscle (Redrawn from Foster). Epiglottis.-The cartilage of the epiglottis is leaf shaped and attached by its apex to the thyroid's inner surface just below the median notch by the thyro-epiglottidean ligament (Figs. 102,103). The epiglottic cartilage is covered by mucous membrane. Its base is free and points backward from the root of the tongue, to which its anterior surface is attached by three glosso-epiglottic folds of mucous membrane, and to the hyoid bone by the hyo-epiglottic ligament. The lateral 254 DISEASES OF THE NOSE, THROAT, AND EAR margins are connected with the arytenoid cartilages by the aryteno-epiglottic folds. Its posterior surface covers the superior aperture of the larynx when food passes down the pharynx. Ligaments.-The larynx has nineteen ligaments-three extrinsic, binding the larynx to the hyoid bone, and sixteen intrinsic, binding its various cartilages together. The extrinsic ligaments are the thyrohyoid membrane and two lateral ligaments (Figs. 102, 103). The intrinsic ligaments are the cricothyroid membrane, the cricothyroid capsular ligaments (two), crico-arytenoid liga- ments (two), crico-arytenoid capsular ligaments (two). In the false cords or ventricular bands the superior thyro-arytenoid ligaments (two). In the true vocal cords the inferior thyro- arytenoid ligaments (two), the hyo-epiglottic ligament, the thyro-epiglottic ligament, and the three glosso-epiglottic folds. Muscles.-There are four pairs of lateral muscles and one central muscle, the arytenoideus, which extends from the posterior surface and outer border of one arytenoid cartilage to the corresponding parts of the other. There are both oblique and transverse fibers, and the action of the muscle is to draw the arytenoids together and close the posterior portion of the chink of the glottis (Fig. 104). It is supplied by both the superior and recurrent laryngeal nerves. The four pairs of lateral muscles are: The crico-arytenoideus lateralis, extending from the pos- terior angle of the base of the arytenoid to the upper lateral border of the cricoid cartilage. This muscle rotates the ary- tenoid inward and, with its fellow of the opposite side, closes the glottis except for the posterior portion, closed as described above by the action of the arytenoideus, bringing the bases of the arytenoid cartilages together. The lateral crico-aryte- noideus are supplied by the recurrent laryngeal nerve. The cricothyroid, extending from the front and side of the cricoid cartilage to the lower and inner border of the thyroid (Fig. 106). The action of this muscle is to tilt the thyroid for- ANATOMY OF THE LARYNX 255 ward upon the cricoid and thus stretch and render tense the vocal cords. It is supplied by the superior laryngeal nerve. The crico-arytenoideus posticus extends from the posterior angle of the base of the arytenoids to the posterior portion of the cricoid (Figs. 104, 105). Its action is to rotate the arytenoids Fig. 107.-Vertical transverse section of the larynx: 1, Posterior face of epiglottis, with i', its cushion; 2, aryteno-epiglottic fold; 3, ventricular band, or false voca, cord; 4, true vocal cord; 5, central fossa of Merkel; 6, ventricle of larynx, with 6' its ascending pouch; 7, anterior portion of cricoid; 8, section of cricoid; 9, thyroid cut surface; 10, thyrohyoid membrane; 11, thyrohyoid muscle; 12, aryteno-epiglottic muscle; 13, thyro-arytenoid muscle, with 13', its inner division, contained in the vocal cord; 14, cricothyroid muscle; 15, subglottic portion of larynx; 16, cavity of the trachea (after Testut). outward and open the glottis while keeping the cords tense. It is supplied by the recurrent laryngeal nerve. The thyro-arytenoideus extends from the angle of the thyroid cartilage and the posterior surface of the cricothyroid membrane into the base and anterior surface of the arytenoid (Fig. 107). Its action is to shorten and relax the vocal cords 256 DISEASES OF THE NOSE, THROAT, AND EAR bringing the thyroid and arytenoids closer together and to compress the sacculus laryngis. It is supplied by the recurrent laryngeal nerve. The action of the intrinsic muscles may be studied by refer- ence in Fig. 98 and the other figures illustrating the anatomy of the muscles of the larynx. Briefly, the chink of the glottis is closed by the action of the arytenoideus and the crico-aryte- noideus lateralis. The cords are tightened and made tense by the action of the cricothyroid. The cords are relaxed by the action of the crico-arytenoideus and separated by the action of the crico-arytenoideus posticus. The study of the action of the muscles of the larynx may also be facilitated by inspect- ing the figures illustrating laryngeal paralysis (Figs. 121-128). The muscles of the epiglottis are three double muscles, all supplied by the recurrent laryngeal nerves. Their action is to depress the epiglottis and compress the sacculus laryngis. The epiglottic muscles are the thyro-epiglottideus, between the inner surface of the thyroid and the epiglottis and aryteno- epiglottic folds; the aryteno-epiglottideus superior, between the apices of the arytenoids to the aryteno-epiglottidean fold; and the aryteno-epiglottideus inferior, from the arytenoid cartilage just above the ventricular bands to the sacculus laryngis. The vocal cords, sometimes called the true vocal cords, in contradistinction to the/u^e vocal cords or ventricular bands, extend anteroposteriorly across the larynx from the angle of the thyroid cartilage to the anterior angle of the arytenoids (Figs. 103-106). They each consist of a fold of mucous mem- brane containing the inferior thyro-arytenoideus ligament with the thyro-arytenoideus muscle parallel to it (Fig. 107). The ventricular bands are two folds of mucous membrane containing the superior thyro-arytenoid ligament extending across the larynx above the ventricles of the larynx (Fig. 107). The glottis, or rima glottidis, sometimes called the chink of the glottis, is the space between the vocal cords. When the cords are separated during forced inspiration it is triangular ANATOMY OF THE LARYNX 257 in shape, with the apex of the triangle anterior. Its length rarely is i inch in the male, and its width posteriorly during inspiration does not exceed | inch. The ventricles of the larynx are oval depressions between the ventricular bands and the cords leading upward toward the sacculus laryngis. The sacculus laryngis is the upper portion of the ventricle of the larynx. It contains sixty or seventy small mucous glands, whose secretion lubricates the cords. It is of conic shape and is covered by the aryepiglottideus inferior muscle medianly and the thyro-epiglottic muscle laterally. Both muscles by their action compress it and expel its contents (Fig. 107). The mucous membrane of the larynx is somewhat thin. It is covered with ciliated columnar epithelium below the level of the ventricular bands, extending up in front as high as the center of the epiglottis. Over the rest of the mucous mem- brane of the larynx is stratified squamous epithelium. The abrupt change in the character of the epithelium of the larynx probably accounts for the rarity of infection of the pharynx extending into the lower air-passages; as it is a well- established fact that infections of mucous membranes generally respect anatomic boundaries when the character of the epithelium covering suddenly changes. The arteries of the larynx are the laryngeal branches of the superior and inferior thyroid. The most important of these from an operative standpoint is the cricothyroid, which extends transversely across the cricothyroid membrane to anastomose with its fellow of the opposite side. This artery is seldom large enough to require ligation in deliberate operating.. However, in emergency cases, where it is necessary to open the cricothy- roid membrane as quickly as possible, it is better to cut the cricothyroid membrane transversely in order to avoid wound- ing this vessel. The veins empty into the superior, middle, and inferior thyroid veins. Ordinarily these are vessels of small size, but 258 DISEASES OF THE NOSE, THROAT, AND EAR in obstructed respiration from stenosis their size is greatly increased. The nerves of the larynx are the superior and recurrent branches of the pneumogas trie joined by branches of the spinal accessory and the sympathetic. The superior laryngeal is mainly a nerve of sensation. It enters the larynx through an opening in the thyrohyoid membrane and supplies the mucous membrane, the cricothyroid, and arytenoideus muscles. The recurrent laryngeal is a motor nerve. It winds from before backward around the subclavian artery on the right side and around the arch of the aorta on the left side, and supplies all the laryngeal muscles except the cricothyroid. In its course it gives off cardiac esophageal, tracheal, and pharyngeal fila- ments. It anastomoses with the superior laryngeal. Aneurysm of the aorta or subclavian pressing on the recur- rent laryngeal nerve produces characteristic paralysis of the laryngeal muscles, and the same is true of hypertrophied or tubercular lymphatics in the mediastinum or in the neck. The size of the larynx varies greatly, being much larger in males than in females and children. At the age of puberty in boys the voice undergoes a rapid change in character and pitch. During this period of change the mucous membrane of the larynx is usually at least somewhat congested, and occasionally individuals are unable to control the pitch of their voices to the extent that they will begin a sentence in a high-pitched voice and end it in a bass voice or the reverse. Musical notes used in singing have a range of about 3I octaves, and voices are classified according to their position in the musical scale into soprano, mezzosoprano, contralto, tenor, baritone, and bass. Soprano, mezzosoprano, and contralto voices are usually found in women, while the male voice is usually either tenor, baritone, or bass. Voice production is the result of the vibration of the vocal cords amplified by the resonant cavities above; that is, the pharynx, the mouth, the nose; in the same manner that the sound of a tuning-fork is amplified and made many times louder by approaching the ANATOMY OF THE LARYNX 259 vibrating fork toward the opening in a wide-mouthed bottle of a sufficient depth to contain a column of air capable of vibration in unison with the fork. The sound produced by the vibrations of the vocal cords is feeble and practically in- audible until it is amplified and made loud by the vibration of the air in the mouth, pharynx, and nose. The size of this cavity can be greatly reduced by the contraction of the palate, shutting off the cavity of the nose and nasopharynx from the space below, and the size and shape of the cavity of the mouth and oropharynx can be changed by the action of the muscles of the tongue and pharynx; so that it is possible to produce a space containing a volume of air capable of vibrating in unison with and amplifying a sound of any pitch produced by the vibration of the vocal cords. The larynx possesses the char- acteristics of both reed and string musical instruments. The pitch of a sound produced by the vibration of the vocal cords depends upon their length, thickness, and tension. What is called the falsetto voice is the result of the cords vibrating, not as a whole, but in two or more segments. The resulting sound is high pitched, far above the natural range of the individual's voice, and possessing a timbre or character usually disagreeable. Voices differ greatly in range, that is, some individuals have no more than a few notes of the musical scale, while others have 2 and even 2| octaves at their com- mand, and above the natural range of their voices a falsetto voice, also of considerable range. Musical notes have three qualities-loudness, pitch, and timbre or character. We have already learned how loudness of voice is the result of the amplification of the sound pro- duced by the resonant cavities of the mouth, pharynx, and nose. The loudness also is dependent on the force and amplitude of the vibrations of the vocal cords. The timbre or character of the voice is as varied as the dis- positions of individuals. It is that quality by which we recog- nize the voice of an individual as different from all other individuals. In singers the timbre of the voice may be sweet 260 DISEASES OF THE NOSE, THROAT, AND EAR and pleasant or rough, coarse, and unpleasant. It may be nasal, from the presence of adenoids or other growths that render the use of the nose as a resonant pavity impossible. Timbre of the voice is probably the result of the relative size and shape of the resonant cavities, the position of the teeth and lips, and the thousand and one anatomic peculiarities of an individual's vocal organs. In this connection it is well enough to insert a word of caution as to the impropriety of suddenly greatly altering the size or shape of the upper respiratory tract, as, for example, by the ablation of very greatly hypertrophied tonsils in the case of professional singers, for fear that the character of their voice may be changed for the worse rather than the better. The singing voice differs from the speaking voice mainly that in singing the tone is sustained at the same pitch for an ap- preciable length of time, while in speaking the voice is continu- ally sliding up and down the musical scale on the vowel sounds. (See Acoustics, p. 330.) DISEASES OF THE LARYNX Anemia--The presence of laryngeal anemia is of especial importance: (i) When associated with functional aphonia. (2) When, during the course of an attack of chronic laryngitis, the mucous membrane covering the aryepiglottic folds, arytenoid cartilages, and ventricular bands is abnormally pale while the vocal cords are the seat of indolent congestion, the patient not being generally anemic. Each of the above conditions is premonitory of laryngeal phthisis. Hyperemia of the larynx is a congestion of the mucous mem- brane of the larynx, most marked where the submucosa is loose, fat, and thick, as upon the aryepiglottic folds, ventricu- lar bands, and ventricles; the epiglottis, vocal cords, and inferior cavity of the larynx being but little altered in color. Its presence renders an individual more prone to contract acute or chronic laryngitis. DISEASES OF THE LARYNX 261 Etiology.-Hyperemia of the larynx is oftenest the result of excessive smoking, especially of cigarette smoking. It also re- sults from working in dusty rooms and amid irritating chemic fumes. Acute laryngitis is an acute inflammation of the mucous membrane of the larynx, sometimes extending to the sub- mucous tissue and muscles. Etiology.-Acute laryngitis is generally the result of exposure to wet and cold, it being in many instances simply an extension of an ordinary coryza downward. Many individuals have an hereditary or acquired tendency toward laryngeal inflamma- tions. The affection also occurs as a complication in measles, variola, scarlatina, typhoid, rbtheln, and chicken-pox, and also Fig. 108.-Laryngitis involving chiefly the false cords as the cause of false croup (Friihwald). Fig. 109.-Swelling be- low the vocal cords from laryngitis hypoglottica chronica (after Ziemssen). as the result of traumatism, such as the inhalation of steam or irritating vapors. When acute laryngitis results from trau- matism, the inflammation frequently assumes the edematous form of the disease, while in children the croupous form is frequently met with. Symptoms.-The voice in almost all cases, becomes al- most aphonic, and its use extremely fatiguing and sometimes painful. In adults the respiration is generally unembarrassed, embarrassed respiration indicating that the inflammation is assuming the character of edema. In children, on the contrary, embarrassed respiration is often the first symptom, assuming the spasmodic character of croup. The expectoration in adults is at first clear, frothy, mucopurulent, but somewhat scanty, abundant expectoration indicating that the disease 262 DISEASES OF THE NOSE, THROAT, AND EAR has extended to the bronchi. Expectoration in children being always very scanty probably explains why the paroxysms of dyspnea are so severe and prolonged, the pain, tickling, and sense of tightness in the throat being in them more severe. The color of the mucous membrane of the larynx as seen in the laryngoscope is always heightened, but varies in different parts of the larynx and according to the degree of the in- flammation, the cords in slight attacks being quite white, while in severe attacks they are so red as to be scarcely distinguished from the surrounding parts. The ventricular bands are also sometimes so swollen as to entirely cover the vocal cords or the cords may be prevented from approximation by swelling of the posterior glottic commissure. Treatment.-It is well to begin with the administration of a saline cathartic. The patient should remain in a warm room, avoid using his voice, and draw into the larynx every two hours the spray from an atomizer containing a i : 10,000 solu- tion of adrenalin. This is readily done by the patient inserting the nozzle of an atomizer in his mouth and inhaling deeply as he presses the bulb of the atomizer. The patient will feel the spray enter his larynx and should continue the use of the atomizer until the laryngeal mucous membrane is well covered by the spray. An application should be made to the interior of the larynx once or twice each day of a sedative and slightly astringent powder (Formula 120) by means of a powder- blower (Fig. 34). In making such an application to the in- terior of the larynx the patient is requested to grasp the tip of his tongue with a napkin and hold the tongue well forward. The operator, holding the laryngeal mirror in his left hand, introduces the mirror into the fauces in such a manner that he sees the reflected image of the glottis. The powder-blower should be held in the operator's right hand, and its nozzle is placed in the pharynx in such a position that it is seen reflected in the laryngeal mirror, and moved until it is observed to point toward the glottis. The patient is requested to say "a," and at the same instant the powder should be blown from the DISEASES OF THE LARYNX 263 powder-blower into the larynx. When an individual says "a" or, indeed, makes any other sound with his vocal organs, the cords are brought together in order to produce it, so that any application made at that instant is limited to the part of the larynx above the cords. Should it be deemed necessary to apply the powder to the larynx below the cords, it may be accomplished by using the powder-blower while the patient holds his breath, or the powder may be carried deep into the bronchi if the powder-blower be used while the patient is inspiring. After the more acute stage of the disease has passed, Formula 118 or even 117 should be used instead of Formula 120 as an application to the interior of the larynx. In the more severe cases, powders of any kind are not well borne, and under such circumstances sprays of cocain, adrenalin, and menthol- camphor-albolene should be employed. The application of cold or heat to the skin over the larynx gives decided relief in the more severe cases. As to the selection of heat or cold, the sensations of the patient would seem to be the best guide. In the writer's experience heat is usually the more grateful. Cold may be applied by means of a Leiter coil, a small ice-bag, or a napkin wrung out of ice- water and applied to the neck over the larynx. It should be changed sufficiently often to maintain the degree of cold desired. Heat may be utilized by applying a Leiter coil upon the skin over the larynx in the usual manner and allowing hot water to flow through the coil. A folded napkin should be placed under the coil to protect the skin, and the temperature of the water should be as high as can be borne comfortably by the patient. The more severe forms of acute laryngitis, fortunately rare, will require careful watching, and the physician should be prepared to prevent suffocation from edema by scarifying the epiglottis or, if necessary, by intubation or tracheotomy. Subacute laryngitis is an inflammation of the mucous mem- brane of the larynx less severe than the acute. Etiology.--Subacute laryngitis commonly results from the 264 DISEASES OF THE NOSE, THROAT, AND EAR same causes as the acute form of the disease. It generally attacks individuals of feeble constitution or it may result from neglecting to treat properly the acute affection. Usually slight dyspnea and hoarseness are prominent symptoms. The former, generally worse at night, sometimes occasions the patient alarm. Feeble individuals, especially children who spend most of their lives indoors, are more liable to attacks of this disease than the robust and those who are much outdoors. A frequent predisposing cause is the admixture of the products of combustion with the hot air supplied from furnaces. A care- ful supervision of the workman each fall when the furnace is put in order for the winter, to make sure that the parts of the fire-box are fitted too tightly to allow any escape of carbon- dioxide gas into the hot-air chamber, will sometimes prevent every member of the household suffering from recurrent attacks of sore throat during winter. Dusty occupations and the frequent inhalation of irritating fumes produce chronic laryngitis and acute exacerbations of the inflammation. By far the most common cause is exposure to cold. However, it is not usually normal respiration of cold air that is responsible for attacks of acute laryngitis, because as long as the nose is normal the air inspired through it is moistened and its temperature raised sufficiently to render it harmless to the larynx. This is not the case in individuals whose noses are sufficiently abnormal to necessitate mouth-breathing, and it is somewhat curious to note in this connection that during the first few years of a chronic nasal catarrh each cold is essen- tially nasal; but in the later stages of the disease the brunt of such attacks is borne by the larynx and trachea. This is probably not due to an extension of the catarrhal disease by continuity of surface, but to increasing hypertrophy of the turbinated bodies, rendering the individual a mouth-breather as soon as he inhales cold air. Many individuals take cold through their feet. The ground is a better conductor of heat than the atmosphere and, therefore, the soles of the shoes should be of heavy material. The shoes should be loose DISEASES OF THE LARYNX 265 about the ankles, so as not to impede the circulation, and so constructed as not to prevent the evaporation of moisture. A dentist friend and patient informed the author that he suffered for years with cold feet until he adopted the plan of wearing low shoes the entire year. During the winter his woolen underdrawers were made long enough to extend over the ankles and protect them. He wore cotton or light wool stockings. Treatment.-The treatment is similar to that of acute laryn- gitis. A most important part of the treatment of acute laryn- gitis is rest, especially of the inflamed larynx. All unnecessary talking should be avoided and no effort made to talk above a whisper. In the case of singers, orators, and actors, where it is of the utmost importance that a normal voice should be re- gained as speedily as possible, absolute rest in bed in a warm room will do much to hasten the desired result; | gr. of calomel with 5 gr. of bicarbonate of sodium should be given every hour until six doses have been taken or the bowels freely moved. If the attack is of sufficient severity to cause some elevation of temperature and a hot, dry skin, i-drop doses of tincture of aconite root should be given every fifteen minutes until three or four doses have been taken, and then every hour until the skin has become moist. Of the other internal remedies, yerba santa usually yields the most speedy and satisfactory results, especially in cases accompanied by fever and a hot, dry skin. A pill containing i or 2 gr. of the extract combined with gr. of strychnin should be given every two hours. The patient should inhale the spray from an atomizer containing a 1:10,000 solution of adrenalin every one or two hours. Cocain and antipyrin have sedative and astringent effects upon the inflamed mucous membrane of the larynx. The application of the former gives relief for only half an hour, and is followed by increased congestion. The effect of cocain can be maintained by frequent instillation of the drug or by fol- lowing its use by a spray of antipyrin, which will maintain the 266 DISEASES OF THE NOSE, THROAT, AND EAR local sedative effects of the cocain in many instances for from two to four hours. After the more acute stages of the disease have passed, and in the milder attacks of hoarseness affecting singers, mineral astringents yield better results than adrenalin, and the spray from an atomizer containing a 2 to 4 per cent, solution of a alumnol may be inhaled by the patient every hour or two with decided advantage. In singers and actors with slight laryn- gitis the neurotic element plays an important part and voice failure when on the stage is largely due to nervousness and fear. Under such circumstances a pill containing gr- of strychnin or a teaspoonful of the fluidextract of coca in a glass of sherry wine, taken immediately before the curtain rises, will do much to secure a satisfactory control of the voice during the perfor- mance. Chronic laryngitis is a chronic inflammation of the mucous membrane of the larynx. Etiology.-It is generally the result of faulty use of the voice by singers or public speakers, and also of excessive smoking, especially cigarette smoking. The smoking of cigarettes is particularly injurious, not on account of the paper wrappers or any peculiarity of tobacco, but from the habit all cigarette smokers soon acquire of inhaling the smoke and bringing it directly into contact with the sensitive mucous membrane of the larynx. It is the very "mildness" of the smoke from cigarettes, in comparison with cigar smoke or that of a pipe, that makes them more injurious. The convenience and cheap- ness of cigarettes also causes the cigarette smoker to light a cigarette whenever he has a few moments to spare and under circumstances when he would not think of smoking a cigar or a pipe, the ill effects of which are generally confined to the pharynx. Dusty occupations and the frequent drinking of undiluted distilled liquors are also causes of the disease, while the affection is sometimes simply the expression of the rheu- matic diathesis. The presence of tumors inside the larynx usually is the result rather than the cause of chronic laryngitis. DISEASES OF THE LARYNX 267 Symptoms.-The voice, as a rule, is chronically hoarse, but the degree of hoarseness varies materially from time to time. In singers the injury to the voice will be manifested in loss of range, diminished endurance, and loss of control. As the dis- ease advances, all vocal efforts will be obviously strained and labored. Cough is by no means a constant symptom. The secretion is at no time very great in amount and diminishes as the disease advances. It is thick, starch-like, and tenacious. Small amounts of mucus frequently collect in the interary- tenoid space and, being suddenly detached by coughing, are thrown out through the mouth to a considerable distance, while little bridges of mucus are sometimes seen with the laryn- goscope extending from cord to cord. There is a constant feeling of constriction, as of a foreign body in the air-passages. Upon inspection certain portions of the mucous membrane of the larynx appear redder than normal; and sometimes the entire mucous membrane of the larynx is of a uniform red color, with the exception of the cords, which may be somewhat lighter in color than the surrounding parts. The mobility of the cords is frequently impaired, either from swelling of the mu- cous membrane covering the arytenoids or from slight muscular pain. Erosion of the interarytenoid space is frequently seen. Prognosis.-Recovery from chronic laryngitis is always slow, and depends upon the faithfulness with which the treatment is carried out. Treatment.-'Constitutional remedies, except in rheumatism of the larynx, are not of the greatest importance; but, as in every other chronic affection, the general health should be im- proved as much as possible. Local treatment consists of the application by the patient several times a day to the affected mucous membrane of a sedative or astringent solution by means of the spray of an atomizer, a 4 per cent, solution of alumnol being especially useful for this purpose. As an office treatment, applications of argyrol (10 per cent.) twice a week sometimes yield excellent results, and the occasional application of nitrate of silver solution in obstinate cases is 268 DISEASES OF THE NOSE, THROAT, AND EAR very beneficial. The use of the remedy requires some care, and a very little of the solution should be used until it is ascer- tained that its use is not followed by spasm of the glottis. Most larynxes will stand the application of a cotton-tipped applicator dripping with a 2 per cent, solution of silver nitrate, and 10 per cent, solutions can be employed cautiously. The unusually slight irritation produced by the application of even the weaker solutions sometimes lasts for several hours, but is followed by decided relief of hoarseness and congestion of the parts. In the more severe cases pain, congestion, and hoarseness are sometimes quickly relieved by the insufflation of powdered orthoform or antipyrin. A milder astringent powder consists of 1 part of alumnol and 2 parts of milk-sugar. It may be used with good effect in all cases of chronic laryngeal congestion. Sulphate of zinc (from 15 gr. to 1 ounce of milk-sugar up to equal parts of sulphate of zinc and milk-sugar) yields good results in some cases. Laryngitis Sicca.-Is the result of atrophy of the glandular elements of the mucous membrane. The disease is generally associated with atrophic rhinitis and pharyngitis. Pathology.-The appearance of the laryngeal mucous mem- brane is similar to that of the nose and pharynx in atrophic rhi- nitis and pharyngitis. In some cases the parts are simply dry and glazed, looking as if varnished; in other cases there are accumulations of inspissated mucus, often greenish in color and emitting an offensive odor, similar to that observed in atrophic rhinitis. The gross structural alterations that are seen in the nose in atrophic rhinitis are not observed in atrophic laryngitis. It is a disease characterized by diminished and perverted secretions rather than by atrophy of mucous membrane, sub- mucous structures, and laryngeal cartilage. The masses of inspissated secretions cling to portions of the larynx where the glands are most numerous-the subglottic region and the upper surface of the ventricular bands. Symptoms.-In cases where there are no accumulations the DISEASES OF THE LARYNX 269 larynx feels dry and irritated. The voice is slightly hoarse and tires upon the slightest exertion. In cases characterized by accumulation of fetid secretions the sufferings of the patient are mainly due to the irritation produced by the presence of these secretions and by the effort to rid himself of them. His strength is exhausted by ceaseless and useless coughing, usually worse at night. Occasionally a little mass will be ejected from the larynx with considerable violence, bringing with it a small area of laryngeal epithelium, and producing a slight capillary hemorrhage which alarms the patient. In a few cases which the writer has seen-for the disease is somewhat rare-the patients were fairly Well nourished. Treatment.-In cases where the disease is the result of atrophic rhinitis, efforts should be directed toward improving the condition of the nose, so that the important function of warming and moistening the inspired air is restored. The wearing of cylinders of absorbent cotten within the nose, as directed for the treatment of atrophic rhinitis, is also valuable in bringing about an improved condition of the laryngeal secretions. Patients with atrophic rhinitis do well in a moist climate. In one case all laryngeal symptoms had disappeared upon the return of the patient to Philadelphia after a year's absence in the Philippines. Internally may be given stimulating ex- pectorants or drugs, such as iodid of potassium and hydriodic acid, that increase the secretions of the upper respiratory tract and render them more fluid. Inhalations of steam or the use of the bottle-inhaler with hot water and tincture of benzoin aid greatly the patient's efforts to get rid of the annoying laryngeal accumulations. Great relief sometimes follows spraying the larynx with equal parts of hydrogen dioxid and Dobell's solution, because the action of the dioxid upon the accumulations softens them and increases their bulk, and hence aids their explusion horn the larynx. The irritation of the larynx is best controlled by spraying the parts with a 2 per cent, solution of antipyrin. 270 DISEASES OF THE NOSE, THROAT, AND EAR Inflammation of the Submucous Tissue of the Larynx.- Acute edema of the larynx usually is the result of phlegmonous inflammation with infiltration of the surrounding submucous tissue, frequently endangering life by occlusion of the rima glottidis. Etiology.-Edema of the glottis may result from traumatism, such as the swallowing of corrosive liquids. It occurs rarely as a primary affection, resulting from exposure to cold and wet in persons of debilitated constitution and also as a neurosis. In most instances, however, the disease is secondary, and results from syphilitic or tuberculous peri- chondritis (Fig. no), retropharyn- geal abscess, Bright's disease, gly- cosuria, etc. Pathology.-The infiltration con- sists essentially of a serous or sero- purulent fluid, most abundant be- neath the mucous membrane of the aryepiglottic folds, the ventricular bands, and the ventricles. The submucous tissue is most abundant in those regions of the larynx, but the edema is not always limited to that part of the larynx above the vocal cords, but may extend to the sub- mucous tissue beneath the vocal cords. Infraglottic edema, as the disease is then called, is almost invariably secondary in its origin and always serous in character (Fig. 109). Symptoms.-In some cases there are no symptoms whatever prior to a fatal suffocation or syncope. The voice is usually rough and deep or altogether lost, due to thickening and heaviness of the cords. In the early stages of an attack the chief difficulty in breathing is during inspiration, but, as the disease advances respiratory distress increases, with the result of producing complete apnea. A short cough is present and deglutition is both difficult and painful. When the edema is considerable the sense of suffocation is most oppressive. With the laryngoscope edema is quickly recognized, the infiltrated Fig. no.-Phlegmonous laryn- gitis, with phthisic ulcer: a, Epi- glottis; b, left aryepiglottic fold; c, left pyriform sinus (from v. Ziemssen, after Turek). DISEASES OF THE LARYNX 271 portion of the larynx being greatly swollen and semitrans- parent in appearance. When the edema is subglottic, the swollen mucous membrane of that region will almost always be seen of a more intense red than the cords above. Prognosis.-Recovery from severe primary edema is always doubtful, and the prognosis in secondary edema depends upon the circumstances of the primary cause of the disease. The patient can hardly be said to be out of danger under two or three weeks from the commencement of an at- tack, and may even then become the subject of chronic infiltration. When death occurs it is almost always the result of carbonic-acid poisoning, and may be the direct effect of stenosis or spasm of the glottis. Another danger is the possible occurrence of suppuration-abscess of the larynx. T reatment.-F ree diaphoresis should be produced in suitable cases by the hypodermic use of to | gr. of pilocarpin or free catharsis with croton oil. The temperature of the room in which the patient lies should be carefully regulated, and cold, dry applications kept upon the throat over the larynx. As soon as edema is seen within the larynx, local scari- fication with the laryngeal lancet (Fig. in) should be per- formed. If, in spite of scarification and the use of pilocarpin, edema continues, with increasing respiratory distress, general enfeeblement, and symptoms of carbonic-acid poisoning, in- tubation or tracheotomy should be performed at once. Many lives probably have been sacrificed by hesitation and delay. Laryngitis syphilitica is an inflammation of the larynx due to syphilis. a b c d e f g b i j 1 Fig. hi.-Heryng's laryngeal lancets, knives and curettes. 272 DISEASES OF THE NOSE, THROAT, AND EAR Etiology.-'Syphilis of the larynx most frequently occurs as a manifestation of the tertiary period, three to many years after the primary infection. As a manifestation of secondary syphilis laryngeal symptoms may oc- cur within a few weeks or may not appear until two or three years after syphilis has been contracted. Pathology.-In secondary syphilis the laryngeal symptoms may consist of a mere hyperemia, giving rise to the symptoms of simple laryngitis. Ulcerations may also be present and are usually symmetric, that is, if an ulcer is present upon one part of the larynx, there is usually a similar ulcer also upon the corresponding part of the opposite side of the larynx. Syphilitic warts or condylomata also are found in the larynx during the secondary stage of syphilis. They may undergo ulceration or disappear spontaneously. Tertiary manifesta- tion consists of gumma, which may break down and cause deep ulcera- tions, with perichondrosis and necro- sis of the cartilages; while stenosis may result from cicatricial contrac- tion after the healing of syphilitic ulcers. Symptoms.-The patient usually first complains of a slight hacking cough, hoarseness, and sometimes difficult and painful deglutition. Inspection with the laryn- goscope reveals some of the lesions already specified. Treatment.-Constitutional remedies already mentioned (see Syphilitic Rhinitis) should be employed. Alumnol or Fig. i 12.-Browne's hollow laryngeal dilator with cutting blade (| measurement). DISEASES OF THE LARYNX 273 some other astringent should be prescribed for the patient's use at home, in the same manner as for simple laryngitis, while an application of Formula 119 should be made to the interior of the larynx every other day with the powder-blower. If shallow ulcers are present they should be touched each day with 12 per cent, nitrate of silver solution. After a time, when the process of repair is beginning to set in, these applications become painful and should be omitted, but insufflations of Formula 119 should be continued until the larynx presents its normal appearance. Should partial stenosis occur as the result of cicatricial contraction, the laryngeal stenosis may be Fig. 113.-A, Cicatricial stenosis before treatment; B, the same after use of cutting dilator (Lennox Browne). overcome by the use of laryngeal bougies or some suitable cutting instrument (Fig. 112). Tubercular Laryngitis.-'Tubercular laryngitis is a chronic laryngitis due to the presence of the tubercle bacilli. Etiology.-It is generally secondary to pneumonic phthisis. In most all instances the cellular tissue of the larynx is the structure first affected. The inoculation in this locality may occur through the lymph-channels, the blood-vessels, or by means of an abrasion in the mucous membrane exposed to tuberculous sputum from the lungs. Inoculation of tuber- culosis in syphilitic ulcers in the larynx has been observed, and it is stated that the presence of simple catarrhal laryn- gitis, either acute or chronic, is a predisposing cause of tuber- culous laryngitis when tuberculosis of the lungs is already present. Hospital reports, mostly German, vary from 6 to 274 DISEASES OF THE NOSE, THROAT, AND EAR 50 per cent, as to the frequency of laryngeal involvement in postmortems on individuals dead from pneumonic phthisis. Probably about one-third of the cases of lung consumption in this country, sooner or later, develop laryngeal lesions. That the larynx is not frequently inoculated by the inspiration of pulverized dried phthisic sputum is probably due to the fact that under ordinary circumstances particles of dust in inspired air are arrested within the nose or pharynx and do not reach the larynx; and in this connection it is interesting to note that those suffering from atrophic rhinitis are proportionately more frequently attacked by pneumonic phthisis than those with normal noses. More frequently tuberculous lesions of the larynx occur on the same side as the lung most affected by the disease, although this is not invariably the case. Pathology.--The lesions in the larynx are similar to those found in tuberculosis elsewhere: Tubercles are formed and the bacilli are disseminated into the surrounding tissues, partly by their own multiplication and partly by lymph-currents, so that the extent of the tissue involvement is always much greater than it appears to the eye of the observer. As the result of nature's efforts to limit the spread of the affection, leukocytes appear about the affected area and a reticulum of connective tissue is formed. Degeneration of the tubercle then occurs as the result of lack of nutrition, and manifests itself as a tissue necrosis, with an ulcer that may involve not only the mucous membrane and cellular tissue, but also mus- cles and cartilages as well. Bacilli appear in the discharges and the tuberculous process extends. In tuberculous individuals there is often observable an ashy gray appearance, differing from the ordinary paleness of anemia of mucous membranes at the junction of the hard and soft palate. The same color is also less frequently observable in the larynx. There is sometimes slight localized congestion of the cords, one of which may be partially paralyzed and sluggish in its movements from the pressure of a hyper- trophied tuberculous lymphatic upon the recurrent laryngeal DISEASES OF THE LARYNX 275 nerve. The voice under such circumstances is somewhat aphonic and perhaps slightly hoarse at times. Characteristic lesions are submucous infiltrations, generally club-like in shape, sometimes involving one or both arytenoids, "pyriform arytenoids" (Fig. 114), or producing the "turban- shaped" epiglottis. Minute tubercles break down upon the cords, producing ulcers that give the cords a "moth-eaten" appearance (Fig. 115). Fungus-like thickening of the inter- arytenoid mucous membrane is common in laryngeal tuber- culosis. Deep ulcerations involving necrosing cartilage is a later stage, from which there are few recoveries. Usually the Fig. 114.-Laryngeal tubercu- losis with characteristic pyriform swelling of the arytenoid cartilages (Lennox B rowne). Fig. i i5.-First stage of tuber- culosis of larynx. Ulceration of right cord and swelling of jnter- arytenoid region with formation of folds. May be early ulceration here (Sahli). concomitant lung lesions have also reached an advanced stage, and the fatal end is hastened by the patient's inability to swallow or even breathe without pain. Differential Diagnosis.-In certain cases the differential diagnosis between malignant ulceration and tuberculosis is one of extreme difficulty. In malignant ulceration the inflamed and reddened appearance of the unaffected mucous mem- brane of the larynx contrasts strongly with the pale and anemic appearance in tuberculosis. There is the lung involve- ment in tuberculosis, the greater involvement of the cervical glands in malignant disease. There are two other conditions of the larynx that sometimes closely simulate tuberculosis in appearance-syphilis and lupus. 276 DISEASES OF THE NOSE, THROAT, AND EAR It should be borne in mind that tuberculosis is sometimes engrafted upon a syphilitic ulcer. Syphilitic ulcer of the larynx follows the breaking down of a gumma. There is usually a history of syphilis or syphilitic lesions may be found upon the body elsewhere. The diagnosis will be cleared up by the Wassermann reaction test. lodid of potassium must be used with considerable care, as tuberculous individuals do badly under it. Lupus is tuberculosis of the larynx resulting from the in- oculation of the larynx with an attenuated tubercle bacilli. It is usually secondary to lupus of the mouth or pharynx, and is an extremely rare disease. Symptoms - In the earlier stages of the disease there are practically no symptoms except perhaps occasional transitory hoarseness or very slight aphonia. These voice symptoms increase as the disease progresses until the voice may be a mere whisper and very hoarse. The interference with vocal- ization may be due to pressure upon the recurrent laryngeal nerve, interarytenoid thickening interfering mechanically with the approximation of the cords, tubercular infiltration of the muscles or involvement of the arytenoid articulations or ulcera- tions upon the cords. A hacking, dry cough is often present when there is interary- tenoid thickening. When ulceration is present the secretions are more abundant and contain the tuberculous bacillus. The secretions are sometimes streaked with blood, but abundant hemorrhage from tubercular ulcerative laryngitis probably never occurs. Pain on swallowing occurs where the infiltration of the ary- tenoids or epiglottis is great, and there is a sense of obstruc- tion in deglutition. Deglutition becomes exquisitely painful when ulceration has occurred upon the epiglottis or in the aryepiglottic fold. Ulceration within the larynx gives rise to little or no dysphagia and liquid gives rise to less pain than solid food. So exquisitely painful is the act of swallowing in some cases that patients have been known to refuse food or DISEASES OF THE LARYNX 277 drink for days rather than endure the torture of swallow- ing it. Prognosis.-Cures have been reported even in the ulcerative stage of the disease, but the progress of the disease in all cases is usually slow and tedious. Harland states that the chances of improvement in tuberculosis of the larynx are nearly as follows: "i. Larynx free from disease; prognosis so far good. 2. Congestion of cords (vasomotor); prognosis good; examination of lungs indicated. 3. Superficial ulcer, localized infiltration or tuberculoma; chances of improvement about 60 per cent. 4. Deep ulceration; chances of improvement about 38 per cent. 5. Lesions of vocal cord, ventricular band, or interary- tenoidfold; chances of improvement about 89 per cent. 6. Lesions of epiglottis or aryepiglottic fold, chances of improve- ment about 29 per cent." Treatment.-The treatment of the milder forms of the disease should be largely systemic. It should be borne in mind that the disease only does great harm when it causes pain or prevents the taking of food, and that occasionally large ulcers have been seen to heal with practically no local treatment. Cutting operations, with the expectation of eradicating the local disease, are probably, in most cases, worse than useless, as it is impossible to know how 'far the bacilli have penetrated the apparently sound tissue about a lesion. Of course, if tubercle papilloma in the interarytenoid or other regions attain such a size as to produce dyspnea, as they rarely do, an effort should be made to remove them; otherwise those growths should be let alone. They frequently recur after removal. Ulcerations should be cleansed with equal parts of Dobell's solution and hydrogen peroxid by means of a spray from an atomizer. After the parts have been cleansed the ulceration should be dusted by means of a powder-blower with Formula 120. Owing to the bulk of the tannic acid contained in this powder the amount of morphin in the quantity thrown by the 278 DISEASES OF THE NOSE, THROAT, AND EAR powder-blower into the larynx is very minute, but if for any reason the morphin is objectionable, it may be omitted from the formula. Excessive pain on swallowing may, of course, be relieved by cocainizing the larynx, either with an atomizer or a laryngeal applicator. A lozenge containing | to | gr. of cocain, dissolved in the mouth before meals, yields fairly satisfactory results. However, for the relief of painful deglutition, no remedy yields such satisfactory results, everything considered, as orthoform. This nearly insoluble substance has the property of producing analgesia when applied to exposed nerve-endings. It is, there- fore, especially valuable as an application to irritable ulcers after they have been cleansed with Dobell's solution and hydrogen peroxid. Its anesthetic effects are increased by a previous application of a solution of cocain and persist for four or five hours. When insufflated into a tuberculous larynx the powder produces a momentary smarting, followed by analgesia more or less complete which persists as long as the powder adheres to the abraded surface or an ulcer. The powder possesses decided antiseptic qualities and promotes the healing of tuberculous ulcerations. It has little effect upon the unbroken mucous membrane. A nurse or one of the patient's friends can be taught to insufflate orthoform into a tuberculous larynx ten minutes before each meal, and in many instances thus secure complete relief from dysphagia. Orthoform is said to be non-toxic, and hence may be used locally in liberal quantities. It may, of course, be prescribed in the form of a lozenge, but with not nearly as satisfactory results as when the powder is insuf- flated into the larynx. A i to 2 per cent, spray of menthol in albolene may be used by the patient, inhaling each time he compresses the bulb of the atomizer. It yields fairly satisfactory results in a few cases. However, before using any application to the larynx himself the patient should, of course, cleanse it as thoroughly as possible under the circumstances by inhaling the spray DISEASES OF THE LARYNX 279 from an atomizer containing equal parts of Dobell's solution and hydrogen peroxid. Fluids, especially if iced, commonly cause much less pain on swallowing than solids, and iced milk can sometimes be taken through a tube with the patient's head hanging over the bed when it would be much more painful to sit up and drink the fluid; but in extreme cases the stomach-tube and rectal alimen- tation will have to be employed. Syrupy lactic acid is a remedy that is said to have the pro- perty of destroying tuberculous structures without attacking the surrounding sound tissues. Its application to a tubercu- lous ulcer is so painful that its use should always be preceded by thoroughly cocainizing the larynx with a io per cent, solu- tion of cocain. The applications can be made at intervals of four or five days and be preceded, if necessary, by curetting the cleansed ulcer. It is best to commence by lightly touching the parts with a 25 per cent, solution of the syrupy acid and gradually increasing the strength from visit to visit as the patient becomes accustomed to the pain. The remedy undoubtedly hastens cicatrization of ulcers and promotes absorption of deposits. It should be used with judgment and caution, as the edema is frequently increased for a day or two if lactic acid is applied too freely or an attempt is made to "rub in" the remedy upon the floor of a tuberculous ulceration. Leprosy of the Larynx.-According to Hollman, among the earlier symptoms are hoarseness and loss of voice. The laryn- geal condition is usually an extension of the pharyngeal and nasal inflammation. In the great majority of cases there is a hypersensitiveness of the larynx instead of anesthesia. Inspec- tion shows the hyperemic mucous membrane of the arytenoids and the aryepiglottic folds, early becoming studded with small yellowish white lepra tubercles and ulcerations. The false cords are swollen, obscuring the true cords. In a few cases leprous ulceration of the epiglottis occurs. In other cases small tubercles in the intraarytenoid space and on both the 280 DISEASES OF THE NOSE, THROAT, AND EAR true and false cords appear, and, like all leprous tuber- cles, thicken and indurate the surrounding tissues, then ulcerate. In some cases the leprous tuberculous growths in the larynx become so great as to completely fill its cavity, necessitating immediate tracheotomy. Treatment consists in the use of eucalyptol spray, with insufflation of orthoform, or a 5 per cent, spray of protargol. Benign Tumors of the Larynx.-The tumors most commonly met with are papilloma, fibroma, angioma, myxoma, and cyst. Symptoms.-The most notable symptom is mechanical obstruction to breathing and phonation proportionate to the size and location of the growth. If the tumor is small and situ- ated upon a vocal cord, dys- phonia results from interference with its vibration, while, if the growth is situated in the an- terior commissure between the cords, aphonia results from the tumor preventing their approximation. If, however, the tu- mor is small and situated above the vocal bands, but slight, if any, subjective symptoms will be noticed. With the growth of a laryngeal tumor, dyspnea increases and asphyxia may suddenly occur unless prompt relief is at hand. Cough is not usually present unless the growth is of such a character as to vibrate in the breath-current and titillate, the in- terior of the larynx (Fig. 116), when cough and laryngeal spasms may occur. Chronic laryngitis is usually present. Papillomata found in the larynx of children offer some pecu- liarities. They are soft and usually multiple. They are usually associated with catarrh of the nasopharynx and hypertrophied tonsils, and sometimes disappear under the application of astringent powders to the larynx and successful Fig. i 16.-Pedunculated fibroma upon the under surface of the left vo- cal cord; position during inspiration (v. Ziemssen). DISEASES OF THE LARYNX 281 treatment of the nasal and pharyngeal affection, to the exist- ence of which in many instances they seem largely due. The papillomata of the adult are harder than those of chil- dren, and are usually situated on the vocal cords or ventricular bands. Etiology.-Any long-continued irritation of the laryngeal mucous membrane may result in hyperplasia and the growth of warts. When the result of long-continued catarrhal inflammation, papillomata usually occupy the interarytenoid space and the posterior ex- tremities of the vocal cords. Papillomatous growths are sometimes seen about tuberculous ulcerations and upon the mucous membrane covering gummata and tu- mors lying underneath the laryngeal mucous membrane. In case the papilloma oc- cur in connection with laryn- geal phthisis, syphilis, or a laryngeal tumor, they result from the irritation to the laryn- geal mucous membrane caused by the primary disease. „ Treatment.-Tumors springing from the epiglottis can usually be removed by means of a snare with a curved lip, while cysts may be opened with the laryngeal lancet (Fig. in) and their contents allowed to escape, after which the end of a probe on which nitrate of silver has been fused should be passed into the cyst and its interior thoroughly cauterized. Papillomata (Fig. 117) and soft or pedunculated tumors should be removed by means of the laryngeal forceps, if necessary picking off piece after piece until the entire tumor has been removed. In every case of tumor of the larynx the emergencies of the case govern the operative procedures necessary. If the removal of the tumor is very urgent to prevent suffocation and the patient's throat is too irritable to permit instrumental Fig. ii 7.-Papilloma of larynx (Stoerck). 282 DISEASES OF THE NOSE, THROAT, AND EAR interference without danger of fatal results from induced spasm of the glottis, tracheotomy should, of course, be per- formed before the removal of the tumor is attempted. It is generally useless to attempt the removal of any laryn- geal growth with the forceps until the larynx has been so thoroughly cocainized that no spasm occurs upon the intro- duction of a probe. This can almost always be accomplished by painting the interior of the larynx with a io per cent, solution of cocain in 1:1000 adrenalin by means of a laryngeal applicator until no spasm occurs when the applicator or probe is introduced into the larynx. In the larynx cocain anesthesia occurs more rapidly than in the nose, but lasts for only a short time. Laryngeal carcinomata is divided into intrinsic and extrinsic. Intrinsic carcinoma attacks the ventricular bands, the ventricle, and the vocal cords, or may be subglottic. Extrinsic carcinoma has its origin upon the epiglottis, the arytenoid folds, and in the pyriform sinus. In extrinsic carcinoma the lymphatic glands are affected almost from the commencement, the disease rapidly advances toward a fatal termination, and is rarely, if ever, cured by operation. Intrinsic carcinoma is a less grave affection; its advance is less rapid, and the neighboring lymphatics often remain for a long time uninvolved. Extirpation, either partial or entire, should not be undertaken except the disease be intrinsic and limited entirely to the larynx. Symptoms.-'Continued hoarseness and sharp pain in the larynx, pharynx, or ear in a person over forty is sufficiently suspicious of carcinoma to render it advisable to keep the patient under observation in cases where no growth is visible by laryngoscopy, so that the all-important advantage of the earliest possible diagnosis is secured. Hoarseness grows worse until the voice is aphonic, while the growth progressively encroaches upon the lumen of the larynx until dyspnea embarrasses the patient. Cough, with the usual scanty DISEASES OE THE LARYNX 283 expectoration of chronic laryngitis, is an early symptom, the expectoration becoming purulent and bloody only after the growth has begun to break down. Dysphagia is an early symptom only in extrinsic cases. In intrinsic cases the cervical lymphatics are not involved until the tumor begins to break down, those in the posterior triangle being involved first from supraglottic lesions, and those at the angle of the jaw first when the disease is sub- glottic. By laryngoscopy a tumor is usually visible in the supra- glottic cases, involving, at least in the early stages, usually only one side of the larynx, with paralysis of a cord, which, fol- lowing Semon's law, involves first the abductors and later in the disease the adductors. Microscopic findings, if nega- tive, are unreliable when based upon the examination of a small piece of the tumor removed by cutting forceps through the mouth, because the cancerous mass maybe superficially papil- lomatous in appearance, both macroscopically and microscop- ically. Growths of this character, operated through the natural passages, have given rise to the impression that papil- loma are prone to degenerate into cancer. Hence, it is bet- ter in all suspicious cases to do a thyrotomy at once even to secure a reliable specimen for microscopic examination, more especially when it is possible to remove the entire growth by this comparatively simple operation. Fig. i i 8.-Krause's nasal and laryn- geal snares and cuiette forceps 284 DISEASES OF THE NOSE, THROAT, AND EAR Treatment.-'Extirpation of the larynx, either in part or as a whole, gives the only hope of cure. The operation should be done as soon as a certain diagnosis is established. After all laryngeal operations on carci- noma and in inoperable cases the x-ray should be used as a most important part of the treatment. A useful voice is retained when only one cord is removed or even when the en- tire half of the larynx is taken away. Foreign Bodies in the Lar- ynx.-'Smooth substances, such as small pebbles, shoe- buttons, seeds of various- kinds, etc., are not apt to lodge in the larynx, but are either removed by a fit of coughing or drop into the trachea. In a case reported by Charles Harper Baker an open safety- pin was retained in the bronchus without marked discomfort for about a year, when one half of the pin was coughed up and a year after the other half. Both portions were much cor- roded. Substances with sharp points, like fish-bones, sand- burs, or pins (Fig. 120), are of- ten partially imbedded in the tissues of the larynx. Symptoms.-'Aphonia may be the only sign of a foreign body in the larynx. Commonly, how- ever, there is a sense of irrita- tion or even pain, and difficult respiration, resulting either from the bulk of the foreign body or the spasm or edema its presence has caused. Fig. 119.-Carcinoma of the larynx (Stoerck). Fig. 120.-A pin imbedded in the posterior portion of the right vocal cord (Seiler). DISEASES OF THE LARYNX 285 Treatment.-The foreign body should be removed with laryn- geal forceps when possible either by the direct or indirect method. In rare cases a wound of the interior of the larynx is rapidly followed by edema of the glottis. Therefore, in some cases tracheotomy should be performed before an attempt is made to remove the offending substance through the natural openings or it may be removed by thy- rotomy; for it should be borne in mind that such an operation is more conservative than prolonged attempts to remove a foreign body in timid children and indocile adults, especially when the operator is also embarrassed by clumsy instruments, imperfect light, or the patient's reflex cough persisting in spite of the thorough cocainization already described as necessary for the removal of papilloma and other tumors. When a bolus of food or a large substance threatens immediate suffocation, the finger should be inserted into the patient's mouth and an effort made to hook the foreign body out of the larynx. Fail- ing in this, a horizontal incision into the larynx through the cricothyroid membrane should be quickly made. If nothing better is at hand, this may be done with a penknife and the blade then turned vertically in such a manner as to hold open the wound and permit respiration. Subsequently the foreign body may be removed by thyrotomy; or after the insertion of a tracheotomy tube, by instrumentation through the mouth. Thyrotomy consists in the separation of the two wings of the thyroid cartilage by means of an incision through the angle of the thyroid cartilage, thus exposing the interior of the larynx for the removal of tumors or foreign bodies that cannot be removed readily through the mouth. The operation is done under chloroform anesthesia and in the trachetomy position. An incision is made through the skin from the thyrohyoid space to the upper tracheal rings exactly in the median line. The underlying structures are divided carefully by means of a knife and a grooved director. The thyroid prominence bulges out of the wound and can be opened by passing one blade of a stout pair of angular scissors through the cricothyroid mem- 286 DISEASES OF THE NOSE, THROAT, AND EAR brane into the larynx. The larynx can also be opened by means of a stout bistoury or, when ossified, by means of a Sajous saw (Fig. 46). The edges of the wound are now separated with retractors in the hands of an assistant, and spasm of the laryn- geal muscles, which always occurs when the larynx is opened, is controlled by brushing the laryngeal mucous membrane with a 4 per cent, solution of cocain. The operation is comparatively bloodless and exposes in a very satisfactory manner the in- terior of the larynx for the removal of a foreign body or a tumor. After the removal of the tumor or foreign body the severed edges of the cartilages are united by one or more catgut sutures and the skin wound brought together by sutures of worm-gut. Union usually occurs by first intention, but the ultimate condi- tion of the voice depends upon the amount of damage done to the interior of the larynx. The removal of a foreign body or small tumor is not followed by appreciable impairment of the voice. The after-treatment following removal of a small tumor by this method consists in keeping the patient quiet in bed for a week or so and forbidding the use of the voice. For the first few days the diet should be liquids. Neuroses of the larynx are divided into sensory and motor neuroses. Sensory neuroses are anesthesia, hyperesthesia, and par- esthesia. Anesthesia of the mucous membrane of the larynx, some- times accompanying motor paralyses of the larynx, is occa- sionally observed in hysteria and in the insane. Hyperesthesia accompanies all forms of laryngeal inflamma- tion except some forms of early tuberculosis. It is frequently present in neurotics. Paresthesia manifests itself chiefly as a sensation of choking or as of a foreign body in the larynx of hysteric individuals. These sensations are sometimes the result of disease of the pharynx or tonsils, and when this condition exists it should NEUROSES OF THE LARYNX DISEASES OF THE LARYNX 287 receive appropriate treatment. In the meantime considerable relief will follow the administration of io to 15 gr. of the bromid of sodium three times a day. Motor neuroses are spasm incoordination and paralysis of the laryngeal muscles. Spasm of the laryngeal muscles appears in three forms-• spasmodic cough, spasm of the adductors, and spasm of the tensors of the cords. Spasmodic laryngeal cough or laryngeal chorea is a con- dition commonly described under this heading, although other respiratory muscles beside those of the larynx are involved in the paroxysms of coughing, which is of a peculiar bark-like character resembling that of a big dog. The paroxysms of coughing occur at frequent intervals during the day, but cease during sleep. The disease occurs more frequently in neurotic females than in males. It is not associated with chorea in any manner whatever, nor is there any evidence of laryngeal inflammation on examination with the laryngoscope. Treatment should be directed toward improving the individ- ual's health. Good results follow the prolonged use of some nerve tonic like pil. sumbul comp., one after meals and at bedtime, but quicker relief can generally be obtained from bromid of sodium, 10 to 15 gr., after meals and at bedtime. The use of the induced current, one sponge on the skin on each side of the larynx, does good probably from the impression it makes on the mind of the patient. To accomplish this the electricity should be used as strong as it well can be borne by the patient. Aside from the use of electricity, local treatment is not indicated. Spasm of the Tensors of the Vocal Cords.--This is a rare condition affecting singers, actors, and orators, somewhat analogous to the spasm of the muscles observed in the muscles of the hand in writers' cramp. Symptoms.-'The voice is suddenly lost, possibly in the midst of a sentence, by a spasm (sometimes painful) of the cords. The greater the effort to speak or sing, the tighter and longer 288 DISEASES OF THE NOSE, THROAT, AND EAR the spasm. After a moment the spasm subsides and the voice is normal for several minutes, when another spasm may occur. Examination with the laryngoscope during a spasm shows the cords tightly approximated in the position for vocalization. There may or may not be slight hyperemia of the larynx. Treatment consists in rest of the voice, preferably in the coun- try or at the seashore, tonics, and attention to personal hygiene. Spasm of the adductor muscles or laryngismus stridulus, false croup, generally involves the crico-arytenoidei externi and the arytenoideus. Etiology.-'The condition usually occurs in neurotic children under three years of age. There is frequently some pathologic condition of the nose and nasopharynx that renders the nerve- endings of the upper respiratory tract more irritable, and in neurotic children is sufficient to induce a reflex spasm of the adductor muscles of the vocal cords from trifling causes, such as a slight lowering of the temperature during the night after the child has gone to bed, kicking off the bedclothing, etc. In some adults the entrance of a small particle of food or dust into the larynx produces a condition similar to laryngismus stridulus. In such individuals applications to the nasopharynx of iodin-potassium-iodid-glycerin; solutions of sulphate of zinc or any of the other routine applications to the nasopharynx may be followed by alarming spasms of the laryngeal adductor muscles if a drop of the solution by any mischance happens to drip into the larynx. The same thing occurs in such individ- uals after the application of an ordinary remedy to the larynx. To the experienced laryngologist the symptoms are suffi- ciently alarming. After the larnygeal application the patient suddenly becomes cyanosed and, with protruding eyeballs, clutches at his throat. The patient gasps. The respiration is loudly "crowing," like that of a child with laryngismus stridulus, and death from suffocation seems imminent. These alarming symptoms disappear as suddenly as they occurred if the patient makes an effort to pronounce words. The practitioner in a loud voice should command the patient to say "One, two, three," or in an equally loud and commanding DISEASES OF THE LARYNX 289 voice inquire, "What is your name?" When the patient makes an effort to answer, the spasm of the glottis vanishes and breathing becomes at once normal. In the first stage of locomotor ataxia there is occasionally a history of spasms of the adductor muscles resembling laryngis- mus stridulus, and in an adult such a history in the absence of foreign bodies gaining entrance into the larynx should be of sufficient warrant to search for other symptoms of this disease. In young children enlargement of the thymus gland may be the cause of dyspnea and death from pressure on the trachea, pneumogastrics, and large venous trunks. The symptoms are expiratory as well as inspiratory stridor, which may sud- denly assume a dangerous character with labored respirations; the patient blue or almost black. Consciousness is lost and the patient quickly dies in convulsions. Diagnosis is most certainly made by means of the x-ray, and while three infants seen by the author recovered under adrenalin spray and expect- ant treatment, the removal of a sufficient portion of the sinus gland to prevent injurious pressure is the most certain method of preventing a fatal termination. Symptoms.-Laryngismus stridulus appears suddenly during the night in apparently healthy children. The child sits up in bed gasping for breath. At the height of the attack it is markedly cyanosed, when suddenly there is a deep inspiration and the symptoms rapidly disappear. There remains no symptoms of laryngeal inflammation except that during the day there may be a slight "croupy" cough. Prognosis.-The attacks of false croup not infrequently recur at intervals for weeks and months. It is said that in very young children the attacks sometimes terminate in eclampsia or convulsions. Treatment is directed to the prompt relief of the laryngeal spasm. This can sometimes be accomplished by making the child sneeze by tickling the nose with a feather or a pinch of snuff. When sneezing occurs the spasms cease. The inhala- tion of a few drops of chloroform from a handkerchief is gen- erally effective. Extreme heat or cold to the skin over the 290 DISEASES OF THE NOSE, THROAT, AND EAR larynx or 3 drops of adrenalin chlorid solution (1:1000) hypodermically will sometimes relieve the spasm. Any or all of these measures should be tried while a hot mustard- bath is being prepared. Then it should be placed in this and, after remaining for a few moments, taken out and carefully wrapped in a warm woolen blanket before being replaced in bed. For very severe attacks Coakley advised the following as a rectal injection: 3. Chloralis hydratis, gr. vj; Potassse bromidi, gr. x; Aquae, q. s. ad. fo j.-M. Sig.-Use as a rectal injection for a child six months old. As a prophylactic between the attacks all sources of irrita- tion should be sought for and removed. These may include errors of digestion, carious teeth, or nasopharyngeal disease. Hearty suppers and lunches at bedtime should be forbidden. Sodium bromid in 5-gr. doses should be given every three hours during the day for a week or more or until the immediate danger of a recurrence of the attack seems to have disappeared. The child should then take syrup of iodid of iron after meals, 1 drop for each year of its age, up to 10 drops, with or without cod-liver oil. Syrup of the hypophosphites may be sub- stituted for the iron at the physician's discretion. In adults, pil. sumbul comp, or some other combination of iron, valerian, and asafetida may be given. Laryngeal Vertigo or Epilepsy.-This is a rare laryngeal neurosis occurring more frequently in males than females. Etiology.-The disease occurs in neurotic individuals, and the symptoms are probably due to an incoordination of the respiratory centers implicating the laryngeal muscles in such a manner as to produce closure "of the glottis. Symptoms.-The prodromes are a tickling sensation in the larynx and a fit of coughing. The patient draws a long breath. The glottis closes and the inspired air is confined in the lungs. There follows vertigo, cyanosis, and sometimes loss of conscious- ness. The "fit" then passes off, to be repeated at intervals. The laryngoscope shows no characteristic lesion; a normal DISEASES GF THE LARYNX 291 larynx or slight catarrhal inflammation being commonly ob- served. Disease of the nose and pharynx, catarrhal in char- acter is frequently present in such cases. The -prognosis as regards life is favorable. There may, how- ever, be a recurrence of the attacks of laryngeal vertigo extend- ing over a period of years. The treatment, like that of other neuroses, consists in hygienic measures calculated to improve the individual's general health, and if the attacks are frequent the administration of antispas- modics. Galvanic electricity, the positive pole over the larynx, may be employed. Paralysis may affect but one laryngeal muscle or pair of muscles; or it may affect several of them at once, and may be either unilateral or bilateral. Paralysis of the larynx may be divided clinically into paralysis of the adductors, paralysis of the abductors, and paralysis of the tensors of the cords. Etiology.-The laryngeal muscles receive their nerve-supply by means of two branches of the pneumogastric-the superior laryngeal and the recurrent laryngeal. The pneumogastric, at its origin, is a sensory nerve, but receives motor fibers from the spinal accessory, so that it possesses both sensory and motor functions above the point where the superior laryngeal is given off. Paralysis of the laryngeal muscles may be due, like paralysis of other muscles, to (i) disease or injury of the brain involving the cerebral portion of the nerves that supply the larynx; (2) injury or pressure of the nerves below their cerebral portion; (3) an abnormal condition of the muscles themselves, and (4) some systemic dyscrasia, like rheumatism or hysteria, because of which the muscles are unable to respond to nervous influence. Adductor Paralysis.-Adduction of the vocal cords being performed by means of the lateral crico-arytenoid muscles and the arytenoideus muscle, paralysis of these muscles causes the cords to remain in a state of extreme abduction. This condi- tion is in most instances due to hysteria, rheumatism involving either the muscles or the crico-thyroid joint, or chronic poison- 292 DISEASES OF THE NOSE, THROAT, AND EAR ing by lead or arsenic. If bilateral paralysis exists, the vocal cords will be seen in the laryngeal mirror separated to the utmost degree (Fig. 12 x), and the voice will be completely lost. If paralysis of the arytenoideus muscle alone exists, which, however, is rarely the case, the anterior two-thirds of the vo- cal bands can be approximated; but a triangular space will be left behind the vocal processes dur- ing phonation, through which the breath escapes and renders the voice feeble, and its use in singing and speaking both fatiguing and unsatisfactory. This condition of affairs may occur during the course of either acute or chronic laryngitis from extension of the inflammation to the arytenoideus In unilateral adductor paralysis only one cord is seen in Fig. 121.-Bilateral paralysis of the adductors (crico-arytenoidei lateralis and arytenoideus). Ap- pearance in attempted phonation (Lennox Browne). muscle (Fig. 122). Fig. 122.-Bilateral paralysis of the arytenoideus (Lennox Browne). Fig. 123.-Unilateral paralysis of adductor of left cord.. Appearance in attempted phonation (Lennox Browne). extreme abduction during phonation, and the opposite cord will be observed to pass beyond the median line, so as to approach as near as possible to its motionless companion (Fig. 123). DISEASES OF THE LARYNX 293 Although aphonia exists, the whispered words are usually perfectly comprehensible. A bductor Paralysis.-Abduction of the vocal cords is accom- plished solely by means of the crico-arytenoid muscle, and hence the complete paralysis of both of them will prevent separation of the cords, and almost completely prevent the entrance of air into the lungs; a mere slit posteriorly, which represents the action of the arytenoideus, being the extent of the available breathing space. During expiration, however, the vocal cords are forced apart by the ascending air-current im- pinging upon their under sur- faces, which curve upward from the sides of the larynx. The voice is unimpaired in this affec- tion, but where complete paraly- sis of the abductors exists it may be necessary to perform trache- otomy to prevent suffocation oc- curring as the result of slight in- flammatory swelling of the mu- cous membrane of the larynx as the result of a cold. Spasmodic abductor paralysis, or "laryngeal crisis," may occur as a complica- tion of locomotor ataxia. Late in the disease one cord, generally the left, is often fixed in a hy- peradducted position. This is in accordance with Semon's law, that in all progressive lesions of the centers or the trunks of motor laryngeal nerves the abductors are more frequently affected than the adductors. Paralysis of the abductors may result from a tumor in the brain involving the origin of both pneumogastrics and spinal accessory nerves. In such cases the abductors of the larynx are first paralyzed, but as the tumor increases in size paralysis of all the muscles of the larynx Fig. 124.-Appearance of the nor- mal larynx after death, showing the "cadaveric position" of the vocal cords. This is also their position in quiet breathing (Lennox Browne). 294 DISEASES OF THE NOSE, THROAT, AND EAR results, the cords assuming the "cadaveric position" (Fig. 124). Paralysis of both posterior crico-arytenoid muscles may result also by pressure upon the recurrent laryngeal nerves by an aneurysm, a goiter, or carcinoma of the esophagus, or the lesion may be located in the muscles themselves. When unilateral paralysis only is present, the affected cord will be seen to remain in the median line, even during forced inspira- tion, but subjective symptoms will be so slight as to hardly attract attention. The voice will be perfect and the breath- ing space ample, except during violent exercise (Figs. 125, 126). Fig. 125.-Bilateral paralysis of the abductors (crico-arytenoidei postici). Appearance with deep in- spiratory effort (Lennox Browne). Fig. 126.-Unilateral paralysis of the left abductor. Appearance in phonation. The affected cord is seen to be in the cadaveric posi- tion, while the other is advanced beyond the median line (Lennox Browne). Two forms of paralysis of the tensors of the vocal cords are met with, one due to paralysis of the cricothyroid muscle, which is rare, and the other one to paralysis of the thyro-arytenoids, which is not uncommon. Paralysis of the former muscle causes the edges of the cords to assume a wavy line, touching each other at irregular intervals during phonation (Fig. 127), while the voice is coarse and remains always at the same pitch. The upper surface of the cords appears convex during expiration and concave during inspiration. When the thyro-arytenoids are paralyzed, the cords assume a slightly curved appearance when an attempt is made to bring them together during DISEASES OF THE LARYNX 295 phonation, and a slight space remains between their centers (Fig. 128). The voice is husky, high pitched, and weak, the air escaping through the elliptic space between the cords, necessitating great effort on the part of the patient in order to speak. Treatment.-The cause of the paralysis should be carefully sought and treated, the success of the measures adopted de- pending, of course, upon the nature of the primary ailment. In suitable cases strychnin should be administered in gradually increasing doses until the limit of toleration has been reached, and galvanism or faradism used by means of the laryngeal Fig. 127.-Bilateral paralysis of the thyro-arytenoidei and of the arytenoideus (Lennox Browne). Fig. 128.-Bilateral paralysis of the sphincter of the glottis (thyro- arytenoide (Lennox Browne). electrode, applied within the larynx as near as possible to the affected muscles. An ordinary sponge electrode is held by the patient or an assistant upon the skin over the larynx, while the operator guides the tip of the electrode into the larynx, watch- ing its progress with the laryngoscope, until it is in the desired position. The finger-rest on the top of the handle of the in- strument is now depressed and the current passes. Each application should last but a few seconds, and be repeated three or four times at each sitting, at intervals of one or two minutes. Electricity may be used in this manner every other day, the current used not stronger than is sufficient to secure 296 DISEASES OF THE NOSE, THROAT, AND EAR contraction of the affected muscles. At first the mere intro- duction of the electrode into the larynx causes retching and gagging, and it may be necessary to apply a io per cent, solution of cocain to the interior of the larynx in order to anesthetize the parts sufficiently to admit of free manipu- lation at the first sitting. After a few trials, however, the parts become more tolerant and applications can be borne, in the majority of instances, without trouble. Diphtheria is an acute infectious disease characterized by a pseudomembrane which usually appears in the fauces, and is associated with a rapid pulse, moderate elevation of tempera- ture, and depression. Etiology.-Diphtheria is endemic in all large cities, especially in the more crowded localities, and from time to time becomes epidemic, spreading to the outlying districts. It is prevalent more in the spring, autumn, and winter than in the summer. The specific cause is the Klebs-Loffler bacillus. Pathology.-The location and extent of the pseudomembrane varies in each case. It may be limited to the tonsils or it may cover the entire fauces and extend into the nares and the larynx. It sometimes extends through the Eustachian tubes to the middle ear. When a diphtheritic membrane is forcibly re- moved it invatiably leaves a bleeding surface. The bacilli are deposited in the fauces first and cause the membrane to become red, inflamed, and swollen. The poison kills the superficial layer of epithelial cells, which undergo coagulation necrosis. There is a migration of white blood- cells, which also undergo coagulation necrosis. These pro- cesses may only extend through the superficial layer of the mucous membrane, but sometimes extend deep into the tissues and produce gangrenous ulcers. The color of the pseudo- membrane is gray or grayish-white at first. It sometimes becomes yellow, but more often is white and flaky, like leaf- lard; it may also assume a dirty brown color, due to hemorrhage or to the local use of iron solutions. Postmortem, the heart and blood-vessels show degenerative DISEASES OF THE LARYNX 297 changes. The heart may contain a blood-clot. The lungs frequently show evidence of fibrinous pleurisy, broncho- pneumonia, or capillary bronchitis. The liver and spleen show little, if any, change. The kidneys frequently show cloudy swelling. Degenerative processes have also been found in the nerve-trunks. Classification.-Diphtheria may be classified as mild, well marked, severe, and malignant. When classified according to location, as faucial, nasal, and laryngeal. There nearly always is some evidence of the disease in the fauces when either nasal or laryngeal diphtheria exists. Symptoms.-In some cases of diphtheria there are very few or no symptoms at all, except a slight indisposition on the part of the child, and the true nature of the disease may never be recognized unless by accident. The ordinary attacks of diph- theria, however, usually begin with chilly sensations up and down the spine; occasionally with a distinct chill and rarely with a convulsion. This is followed by a rise in temperature, quickened pulse, headache, pains in the limbs, coated tongue, and sometimes nausea and vomiting. Frequently there is stiffness of the muscles of the neck. Sore throat and painful deglutition may or may not be present. The temperature rises to ioi° or 103 0 F. by the end of the first day. The pulse is rapid and ranges between no and 130. The throat looks red and inflamed at first, then there is a deposit of exudate on the tonsils, as a rule, and it spreads to the adjacent mucous membrane or may limit itself to the tonsils. It is first of a gray or grayish-white color, which be- comes white or a dirty yellow as it grows older. The glands at the angle of the jaw become swollen and sensitive. Con- stipation is frequently present. The urine is scanty and high colored. It may show albumin and even casts. In the ordi- nary cases the depression is never profound and may be absent altogether. In favorable cases the disease reaches its height by the fifth 298 DISEASES OF THE NOSE, THROAT, AND EAR or sixth day, but the temperature usually falls to normal on the third or fourth day. The exudate usually disappears by the tenth day and convalescence is well established. Paralysis follows but seldom in cases where the exudate is limited to the tonsils. In severer types of the disease the initial symptoms are more pronounced. The depression is marked and comes on early. The fauces are greatly inflamed and the tonsils so swollen as to meet in the center of the pharynx. They are covered by a thick exudate, which impedes respiration and articulation. The uvula is swollen and usually covered by exudate, which extends forward to the hard palate, and may be nearly | inch thick at the junction of the soft and hard palate. The posterior nares are involved by extension of membrane up the posterior surface of the uvula. This often rapidly extends to the anterior nares and both nostrils may become completely plugged by the exudate. There is a serous acrid discharge from the anterior nares which excoriates the skin of the upper lip. The cervical glands are markedly enlarged and the cellular tissues swollen and edematous. The edema at times extends down upon the sternum for several inches. The temperature is usually normal or subnormal after the second or third day. The pulse is rapid, but soon becomes irregular and intermittent. Depression is marked from the beginning. The urine is scanty and high colored. Most severe cases show albumin and casts. Vomiting is frequent. Epistaxis and hemorrhage from the fauces and buccal mem- brane are common. The breath is offensive. The patient rapidly grows pale and anemic. The skin on the face has a drawn and glossy appearance. The child may die in a few days, overwhelmed by the diphtheritic poison, or linger for several weeks and die of toxemia or paralysis. Any case of diphtheria, however severe, may recover, or death may occur suddenly from paralysis of the heart. When recovery takes place, con- valescence is usually protracted and very tedious. Paralysis, either local or general, often supervenes, DISEASES OF THE LARYNX 299 Nasal diphtheria usually occurs in conjunction with the faucial variety or it may follow it. Occasionally it occurs as a primary disease; then the symptoms are milder and the exu- date is not so extensive. There is always a marked tendency to systemic infection whenever the nares are secondarily in- volved. Convalescence is slow and tedious in cases that recover. Variations from the above descriptions are numerous, for no other disease presents so many phases as diphtheria. In laryngeal diphtheria there are hoarseness and a high- pitched, metallic cough-the so-called croupy cough-which comes on in paroxysms. There is a slight rise in temperature and the frequency of respiration is slightly increased. As the exudate extends, the hoarseness and aphonia increase. Fin- ally, the respiration becomes embarrassed and stridulous. The auxiliary muscles of respiration are brought into action. There is marked retraction in the supraclavicular and supra- sternal spaces; also at the substernal space and at the border of the ribs. The alae of the nose dilate with each respiration. The inspiration is long, deep, and labored, and more difficult than expiration, which may be comparatively easy. The child is restless, clutching at the sides of the bed or anything to raise itself up. The face is pale and bathed in a profuse perspiration. The patient has a wild, hunted expression. As the obstruction increases, cyanosis appears, the extremities become purple, the lips and face of a livid hue. Sometimes during a fit of coughing membrane is expelled as a complete cast of the larynx, trachea, and sometimes even of the smaller bronchi. This, as a rule, only gives temporary relief, for the membrane quickly re-forms and all the symptoms return. Unless these cases are relieved by intubation or tracheotomy, cyanosis becomes greater until the child dies asphyxiated. Diphtheritic paralysis is a neuritis rather than a true paralysis due to the absorption of the toxalbumins of the disease, and generally is proportionate to the severity and extent of the acute condition. Rarely, marked paralysis follows mild attacks 300 DISEASES OF THE NOSE, THROAT, AND EAR •-io to 20 per cent, of diphtheria cases are followed by paral- ysis-which may be either local or general. The local variety is usually noticed by the end of the first or during the second week. The most frequent paralysis is that of the palatal mus- cles, giving a nasal sound to the voice. Fluids are regurgit- ated during swallowing. Strabismus and ptosis are sometimes seen. Paralysis of accommodation is not infrequent and paral- ysis of the tensor tympani and stapedius occasionally occur. Facial paralysis is occasionally seen. Loss of power in the lower extremities with inability to walk is quite common. General paralysis usually makes its appearance from the fourth to the sixth week, and all the muscles of the body may be affected except the sphincters, which are usually spared. When all the muscle of the body are affected the temperature is usually subnormal, the pulse rapid and intermittent or very slow. When paralysis is extreme the child lays perfectly quiet, unable to move, and frequently unable to swallow. There -is usually associated with these conditions a low drag- ging cough quite characteristic. Systemic Infection or Toxemia.-'Some of the mild cases have very little constitutional disturbance. On the other hand, some patients are overwhelmed by the poison in a few days. More often toxemia comes on later, when acute symptoms have subsided and the exudate disappeared. The patient appears bright and is apparently convalescing, except that his color is noticed to be growing paler. The pallor increases daily until the pink hue disappears from the lips, lobes of the ears, the palms of the hands, and soles of the feet. Exhaustion is ex- treme. The temperature is usually subnormal. The pulse may be slow or very rapid. The extremities are cold. The stomach is irritable. The least food, even cracked ice, will excite vomiting. The mind remains bright and clear. Such cases usually die of toxemia and exhaustion, and follow when the local disease has been extensive and the depression well marked. Complications.-'Epistaxis is frequent when the nares are DISEASES OF THE LARYNX 301 involved and, in severe cases, hemorrhage from the fauces and buccal mucous membrane. Capillary bronchitis or broncho- pneumonia is quite common and frequently fatal. It occurs during the height of the disease or during convalescence. A fibrinous pleurisy is frequently seen postmortem and occurs in conjunction with bronchopneumonia. Albuminuria is present in nearly all severe cases and occasionally gives rise to alarming symptoms. Suppression of urine may follow. Otorrhea is not uncommon, and bacilli are found in the dis- charges for many weeks or even months after convalescence is fully established. Pericarditis and endocarditis may also occur, but are rare. Diagnosis.-The characteristic pseudomembrane, which leaves a bleeding surface when removed, its gray or grayish- white color, its tendency to spread to adjacent mucous mem- brane, the swelling of the cervical glands, and the presence of the bacilli renders the diagnosis in typic cases quite easy. Mild cases may be confounded with follicular tonsillitis. The anginose variety of scarlatina may present some difficulty, but the strawberry-tongue, continued high fever, absence of the Klebs-Loffler bacilli, and the presence of the characteristic scarlatinal rash will exclude diphtheria. Bronchopneumonia may be mistaken for the laryngeal variety. In pneumonia the respirations are panting and rapid; in laryngeal diphtheria they are long, deep, and labored, and the stridor usually well marked. The history of a faucial or nasal diphtheria will often clear the diagnosis. Prognosis depends upon the character of the epidemic, the type of the disease, and the age of the patient. The death-rate depends upon the number of laryngeal cases requiring operative interference. From this class alone the death-rate varies from 30 to 75 per cent. The age of the patient also influences the prognosis. Under one year of age, from 50 to 90 per cent, die; from one to five years of age, about 40 per cent.; from five to ten years, 26 per cent.; from ten to fifteen years, 12 per cent.; over fifteen years, 3 to 4 per cent. 302 DISEASES OF THE NOSE, THROAT, AND EAR Treatment is divided into (1) prophylactic; (2) local; (3) constitutional; (4) serum; and (5) operative. Prophylactic treatment consists in adopting those measures that will prevent the spread of the disease. This is best obtained by placing the patient in a well-ventilated room, preferably on the top floor, and having it isolated. All bed- linen, towels, garments, and eating utensils used by the patient should be disinfected with a carbolic acid solution (5 per cent.) before leaving the room. The attendant's clothing should be changed before mingling with other people. The physician should wear a linen duster or gown when visiting the patient. After the patient has recovered the room and its contents should be disinfected thoroughly with formaldehyd gas. Local treatment is to reduce the inflammation, prevent the spread of the exudate, and remove what has already formed. For this purpose hydrogen peroxid, either in full strength or diluted to suit the case, is the best local application. It should be used in the form of a spray or upon a cotton swab. Many favor astringent solutions, preferably of the iron salts; as, B. Acidi carbolici, TTlxv; Ferri perchloridi, f 3 ij; Glycerin, Aqua, aafgj.-M. Sig.-To be used every hour or two by means of a swab. The solvents-'lactic acid, peptin, caroid, trypsin-'have many advocates. Lennox Browne was very partial to lactic acid applied pure twice daily, and diluted to three or four times its bulk with water, applied by the attendant every two or three hours. Lbffler's toluol solution gives good results in some cases, but care must be used in applying it. Applications of a solution of 12 per cent, nitrate of silver carefully to the tonsils, palate, and lateral walls of the pharynx twice or thrice a day when they are alone affected seems to check the extension of the membrane, but whatever remedy is selected, the practi- tioner should see that it does not increase the inflammation or else it will do more harm than good. DISEASES OF THE LARYNX 303 Constitutional Treatment.-Iron and mercury are the two drugs we have to rely upon in fhe treatment of this disease. They may be used alone or combined as follows: I|. Tr. ferri chloridi, 3ij; Syr. acidi citrici, Glycerin, aa 5iij; Aqua, q. s. ad. fgiij.-M. Sig.-1 teaspoonful every hour or two for a child four years old. 1$. Hydrarg. chlor, corros., gr. iss; Tr. ferri chlor., f 3 ij; Syr. acidi citrici, Glycerin, aa f giij; Aqua, q. s. ad. f§iij.-M. Sig.-1 teaspoonful every hour or two for a child four years old. Instead of the bichlorid, calomel may be given (A-gr. doses every two hours). Stimulants are indicated from the beginning; alcohol is undoubtedly the best and should be pushed to its physiologic limit in severe cases. After the exudate disappears the whisky should be gradually withdrawn and digitalis substituted. When the stomach is irritable, digitalin should be given. A child five years old can be given to A gr. or more if necessary. Strychnin is also useful, especially in the later stages. It can be given in larger doses than is ordinarily employed. The Serum Therapy.-To obtain the best results, antitoxin should be used early in the disease, and should be used in all cases of suspected diphtheria. In mild cases 1000 units, repeated the next day, will be all that is necessary. In severe cases it is well to begin with 2000 units as the initial dose and repeat every six, twelve, or twenty-four hours, until the symptoms begin to subside. When the disease persists it is sometimes necessary to give as high as 20,000 units in divided doses. Antitoxin of the highest potency should always be selected, for this gives the maximum number of units and the minimum amount of serum. It should be injected under an- 304 DISEASES OF THE NOSE, THROAT, AND EAR tiseptic precautions to prevent abscesses, which occur in spite of antiseptic precautions in about 1 case in 500. Operative intervention is indicated: (1) When the patient is cyanosed, together with marked retraction of the supracla- vicular, substernal, and subcostal spaces, great restlessness, cold and clammy sweats. (2) When the symptoms of obstruc- tion in the larynx are not so marked, but are rapidly growing Fig. 129.-O'Dwyer's intubation set. worse, intubation preserves the strength of the patient. (3) When the symptoms of obstruction are not progressing, but are sufficient to prevent the patient obtaining rest. (4) In severe cases of nasal and faucial diphtheria which develop laryngeal symptoms, intubation permits the patient to die easy. Intubation.-Select a tube suitable for the age of the patient, pass a strong silk thread through the eye of the tube (about 20 DISEASES OF THE LARYNX 305 inches long), and tie the two ends together. Then screw the ob- turator on the introducer and place the tube on the obturator. Next, wrap the patient tightly in a sheet with his hands at the side to prevent them from interfering with the operator. Have the nurse sit in a chair and hold the patient upon her lap with his back to her left chest and his legs between her knees. The operator should sit in a chair facing the patient and place the Fig. 130.-Intubation: inserting the tube {American Text-book of Diseases of Children). gag in the left corner of the mouth. An assistant standing behind the nurse holds the gag and steadies the patient's head between his hands. Then the operator, taking the introducer in his right hand and holding the thread attached to the tube on one finger, rapidly introduces the index-finger of the left hand over the tongue until it is behind the epiglottis and the laryngeal orifice is felt. Then the tube is introduced 306 DISEASES OF THE NOSE, THROAT, AND EAR over the tongue, being careful to keep it in the median line, until the tip of the finger at the opening of the larynx is felt (Fig. 130). Next, elevate the handle of the introducer until the tube is in a vertical position and it readily slips into the larynx. When the tube is in the larynx, press forward the button on the top of the introducer, which releases the obtu- rator. The finger should be placed on the head of the tube until the obturator is entirely withdrawn. Next, remove the gag, but hold the end of the string until you are satisfied the tube is in the larynx and the child has obtained relief. This usually requires three or four minutes. After respirations become easy, the string should be removed or plastered on the side of the face. To remove the string the gag should be placed in the mouth and the finger should be held on the top of the tube until the thread is removed, to prevent removing the tube also. Accident Following Intubation.-Occasionally the membrane of the larynx becomes detached and is pushed down before the tube, completely obstructing respiration. It does not often happen, but when it does the tube should be removed at once by pulling on the thread attached to the tube. This is fol- lowed by a forced expiratory effort, which, as a rule, expels the membrane. When it does not, tracheotomy should be per- formed immediately. After intubation, deglutition is difficult, the patient being able to swallow only liquids and semisolids. The temperature may remain normal, but, as a rule, it rises to 1020 to 1030 F., and remains from 1 to 2 degress above normal while the tube is in the larynx. When intubation gives perfect relief, the respirations are free and easy and the child is entirely com- fortable. The coughing attendant upon deglutition is suffi- cient to keep the tube patulous; but should it become occluded or the respirations labored, the tube should be removed and cleansed. The reintroduction should depend on the character of the respirations after removal of the tube. In some cases the patient coughs up the tube when it becomes occluded, but when the tube is being constantly coughed up it indicates that DISEASES OE THE LARYNX 307 it is too small and a larger size should be used. In favorable cases the time for removal of the tube will depend to a great extent upon the age of the patient. In children six or seven years old the tube may be removed in four or five days; in younger children it should remain five to seven days. When death results after intubation it is almost always due either to the extension downward of the membrane or to bronchopneumonia. An amazing and distressing complication that sometimes arises is the inability of the patient to breathe without the tube. Children sometimes are obliged to wear the tube one hundred and ten days, being entirely well, except that they could not breathe without it. The prolonged wearing of the tube some- times produces ulcers in the larynx, which may result in com- plete occlusion of that organ or so constrict the lumen that a tracheotomy is necessary. Extubation.-The patient is prepared in the same manner as for intubation. The gag is introduced and an assistant steadies the head of the patient. The operator introduces the left index-finger in the mouth until the tube is felt behind the epiglottis. Then, with the extractor in his right hand, the beak is glided over the tongue until the tip of the finger is felt at the opening of the tube, when the handle is elevated and the beak of the extractor slips into the tube. Then, pressing the lever on the top of the handle, the blades of the beak separate and hold the tube securely until it is withdrawn. 7 reatment for Intubation Patient.-When the nares are in- volved they should be syringed several times daily with the normal salt solution, otherwise local treatment is unnecessary and may be harmful. Steam generated in the presence of the patient is no longer considered necessary. Constitutionally, stimulants should be given as required, preference being given to alcohol and strychnin. Calomel in small doses often seems to do good in limiting the inflammation and preventing broncho- pneumonia. Iron mixtures are difficult to swallow and are just as well omitted. A simple cough mixture containing am- 308 DISEASES OF THE NOSE, THROAT, AND EAR monium carbonas and syrup of ipecac often aids in liquefying and expelling the mucus from the throat. The most important element in the treatment is the nourishment. Milk should be given freely. Broths of all kinds, beef-tea, milk-toast, and ice-cream may be given freely. The method of administration of food and medicines is a much-mooted question. Nursing infants take nourishment readily from the nursing bottle. In such cases lowering the head makes swallowing easier, as none of the food gets into the tube. In older patients it is best to permit them to take their food from a glass or in any way they prefer. Struggling to make the patient take it in a specified way produces ex- haustion and is harmful. When children will not take food, they should be fed by introducing a soft-rubber catheter through the nose into the stomach. Tracheotomy is indicated in the same cases as intubation and for the same reasons. In addition, it is indicated in those cases of intubation where the membrane has extended below the tube. It is also performed in cases of foreign bodies in the larynx or lower air-passages, malignant or benign growths in the larynx, edema of the larynx, fracture, gumma, tuberculosis, and spasm of the larynx. High and Low Operations.-The high operation is an opening into the trachea through the cricothyroid membrane, including, in some instances, the cricoid cartilage and the first ring of the trachea. The incision into the trachea is above the thyroid isthmus. The low operation is an incision of the trachea below the thyroid isthmus. In this situation the opening into the trachea can be made longer, and for this and other reasons is usually the preferable operation. Tracheotomy has been characterized as one of the most easy or one of the most difficult of surgical operations. The difficulties of the operation are enormously increased by the presence of a fat short neck and venous congestion. Anesthetic.-In diphtheria and where there is stenosis of the larynx from any cause or great inflammation or irritability of DISEASES OF THE LARYNX 309 the larynx and trachea, choloroform is the preferable anesthetic. In cases where the supply of oxygen has been deficient for some time it seldom requires more than a few whiffs of chloro- form to produce unconsciousness. The chloroform, therefore, should be used with great care. Cocain may be employed locally in adults by injecting one- quarter of a 1 per cent, solution subcutaneously along the line of incision. From 2 drams to | ounce of the solution should be necessary to produce local anesthesia. Fig. 131.-Position of patient for tracheotomy {American Text-book of Diseases of Children). Instruments Required.-The instruments required are a small scalpel, a bistoury, stout angular scissors, dissecting forceps, one-half dozen hemostats, grooved director, catgut ligatures, tenaculum, two blunt retractors, and tracheotomy tubes (Fig. 132). Preparation of the Patient.-The patient is placed on the table with a small pillow, filled with sand, under his shoulders in such a manner as to bring the trachea prominently into view (Fig. 131). However, it is best not to adjust the sand-pillow until after the anesthetic has been given. The skin of the neck is 310 DISEASES OF THE NOSE, THROAT, AND EAR scrubbed with green soap and washed with benzene and then with alcohol. Wet bichlorid towels are then placed over the chest and scalp and under the neck and shoulders. The High Operation or Laryngotracheotomy.-For the high operation an incision is made in the median line ftom the top of the thyroid cartilage to the second tracheal ring. The handle of the scalpel is used to uncover the cricothyroid membrane (Fig. 102), on which will be seen, extending transversely across the cricothyroid artery and vein. Pushing these to one side, a transverse incision is made through the membrane and mucous membrane of the larynx. A tracheotomy tube is then inserted. This is the simplest and easiest form of the "high operation" and is properly called laryngotomy. It is useful in cases of im- minent suffocation, when there is not time to perform a de- liberate low tracheotomy. In cases where sufficient room is not secured by a transverse incision of the cricothyroid membrane, laryngotracheotomy is necessary. This consists in dividing the cricoid cartilage and the first ring of the trachea. Below this point there is danger of wounding the isthmus of the thyroid gland and causing profuse hemorrhage. The cricoid and first ring of the trachea are divided either by the scissors, one blade being inserted within the trachea through the incision in the cricothyroid membrane, or the trachea is steadied by the tenaculum and a bistoury is inserted in the wound and made to cut through the cartilage. In adults the cricoid is not infre- quently partially ossified, so that a somewhat stout pair of scissors is required to sever it. The Low Operation.-The incision should extend from the cricoid cartilage to within 1 inch of the sternum. When the skin is divided the transverse fascia will be brought into view. An opening is made in this near the middle of the wound by lifting it up with the dissecting forceps and incising it suffi- ciently to permit the introduction of a grooved director, which is thrust upward to the upper border of the wound. No vessel of any size being visible over-the director, the fascia is DISEASES OF THE LARYNX 311 incised. This is repeated in the lower half of the wound. The deep fascia uniting the two pairs of muscles, the sterno- hyoid and sternothyroid, is now brought into view and is treated in the same manner, but care should be exercised in using the knife and grooved director that the cuts in the fascia extend completely to each angle of the wound to prevent it becoming funnel shaped by the time the trachea is reached. A layer of areolar tissue and fat is now encountered contain- ing many engorged veins. These, if possible, are pushed to one £lde as the operator proceeds with grooved director and knife to uncover the trachea. If it is impossible to push a vein to one side, two ligatures are passed under it and tied some dis- tance apart, after which the vein is cut. 'The wound is now widely opened by means of blunt re- tractors in the hands of an assistant. Its depth, especially at the lower extremity, may perhaps appall the inexperienced operator, who, however, can assure himself that he has not "missed the trachea" by tracing its course in the wound from above downward with his finger-tip. His fears will be quieted when, after carefully separating the fat and loose connective tissue in the median line, the trachea finally is uncovered, first at the upper end of the wound, where it lies most super- ficially. In this locality also during the operation will prob- ably appear the isthmus of the thyroid gland. This should be pulled upward out of the way by an assistant or, should that prove impossible, the isthmus can be cut between two ligatures. The trachea having been reached and the wound dry and free from blood, the tenaculum is inserted in it in the median line near the upper portion of the wound with the point of the tenaculum directed upward. The use of the tenaculum is necessary because of the constant movement of the trachea. The trachea being steadied by the tenaculum, the point of a bistoury or scalpel is inserted in the trachea in such a manner as to pierce its mucous membrane, but not to cut the posterior wall of the trachea. Cutting carefully and avoiding long 312 DISEASES OF THE NOSE, THROAT, AND EAR sweeps of the knife, which might endanger the posterior wall, three rings are cut, one after the other, with a perceptible snap, yielding in an adult an incision in the trachea about | inch in length. The knife is now withdrawn and a hemostat inserted and opened, widely separating the edges of the tracheal incision. The moment the trachea is opened, any blood in the wound is sucked into the trachea and immediately violently expelled together with any mucus contained in the trachea. The lungs Fig. 132.-Tracheotomy; A, Tracheotomy-tube with pilot; B, tracheotomy-tube in position (Stoney). then seem to empty themselves of air and the patient stops breathing for a period which may be an anxious one to an inex- perienced operator. Finally, a long deep breath is taken, and from then on the respiration is normal. The tracheotomy- tube should now be inserted and be secured by tapes (Fig. 132, b). The upper end of the wound is secured by sutures, a portion at least of the lower end being allowed to remain open for drainage. A rectangular piece of iodoform gauze suffi- ciently large to cover the wound is slit in such a manner that it can be inserted underneath the shield of the tube next the skin, DISEASES OF THE LARYNX 313 and is held in place by the tape. A handkerchief is tied loosely about the neck in such a manner that a flap falls down over the tube and prevents the entrance of dust and other materials, and also receives secretions which are coughed out through the tube and immediately sucked back into the trachea unless absorbed by the handkerchief or gauze and removed by the attendant. In diphtheria cases the inner tube should be removed and cleansed by the nurse every two hours or oftener should the circumstances require it. When neces- sary the outer tube should be removed and cleansed by the surgeon. The reintroduction of the tube is facilitated by the pilot (Fig. 132, a). After tracheotomy, during the time the patient is confined to his room, generally a week or two, the air of the room should be kept at a temperature of 8o° F. and impregnated with steam from boiling water. In diphtheria cases the steam aids in keeping the secretions moist and liquid and tends to prevent the occurrence of tracheotomy bronchitis or pneumonia. A liquid diet should be maintained for a few days after the operation. The wound above and below the tube usually heals rapidly, but exuberant granulations about the tube may require re- moval by scissors or curette. THE EAR ANATOMY OF THE EAR The ear is divided into the external ear, comprising the au- ricle or pinna and the external auditory canal; the middle ear, Comprising the membrana tympani, cavity of the tympanum, Roof of Sony Meatus Sead o/"Malleus ftoofof Tyfnpanurn Semicircular Canals facia/ Aerae Acous/ic Aerie Cerume- nous Glands Cochlea floor of Bony Meatus EustacAAm Tide laid open Short Irocess frikmus'' '%>orqf7ympaJi'^ Fig. 133.-Front view of the organ of hearing (Randall). the mastoid cells, and Eustachian tube; the internal ear, or labyrinth, comprising the vestibule, the semicircular canals, the cochlea, and the auditory nerve (Fig. 133). THE EXTERNAL EAR The Auricle or Pinna.-The auricle is an irregular mass of reticular cartilage deficient at certain parts, where it is con- nected by fibrous tissue and muscles. The cartilage is covered 314 ANATOMY OF THE EAR 315 by perichondrium, outside of which is firmly adherent skin, containing sweat and sebaceous glands. The names given to the elevations and depressions of the pinna are the helix, antihelix, fossa of the helix, fossa of the antihelix, tragus, antitragus, concha, and lobule (Fig. 134). Muscles of the Auricle.-Those on the anterior surface are the tragicus, the antitragicus, the helix major, and the helix minor. Those on the posterior surface are the transversus auriculae and the obliquus auriculae. Those which connect the auricle with the side of the head and move the pinna as a whole are the attolens, at- trahens, and retrahens aurem. The lobule of the ear is the inferior, soft, pendulous part of the pinna, consisting of fat and connective tis- sue covered by skin (Fig. 134). Vessels and Nerves.-The arteries are the anterior auricular branch of the temporal artery; the posterior auricular artery; a branch of the ex- ternal carotid; and the auricular branch of the occipital artery. Corresponding veins accom- pany the arteries. The posterior auricular artery is some- times cut by the first incision in mastoid operations and causes a somewhat profuse hemorrhage, which is readily controlled. The nerves are the auricularis magnus, from the cervical plexus; posterior auricular, from the facial nerve; the auricular branch (Arnold's), from the pneumogastric; the auricular temporal, from the inferior maxillary division of the fifth nerve; and branches from the occipitalis major and minor. The external auditory canal is composed of a cartilaginous and a bony portion. It is about i| inches in length, the carti- laginous portion being about | inch in length, and forming rather less than one-half the canal, which extends from the concha to the drum-head. The external auditory meatus is Fig. 134.--Pinna or auricle (Gray). 316 DISEASES OF THE NOSE, THROAT, AND EAR lined with a continuation of the skin of the auricle, which within the canal contains hair-follicles and ceruminous glands. These glands are most numerous at the junction of the carti- laginous and bony portions. The course of the canal is gen- erally described as that of a spiral turned anteriorly inward and downward; but in some individuals the canal is so straight that the drum-head may be inspected by simply illuminating the canal by reflected light. It should be borne in mind that the auditory canal is narrow- est near its central portion, beyond which it again expands into a sort of pouch terminating at the drum-head-an anatomic construction which adds to the difficulties of removing a foreign body should it penetrate beyond the narrowest portion of the canal. Pressure in front of the tragus usually closes the lumen of the canal; and, owing to this valve-like arrangement, the entrance of foreign bodies into the canal is rendered more difficult. The striking feature of the cartilaginous meatus is the incisurae Santorini, which completely divide the cartilage into three half rings, united by fibro-elastic tissue. THE MIDDLE EAR The membrana tympani is a thin, elastic membrane stretched obliquely across the fundus of the external auditory canal in such a manner that its upper and posterior portion is most external. It is divided horizontally by the anterior and pos- terior folds into two unequal portions-the membrana flaccida or Shrapnell's membrane and the membrana tensor or mem- brana vibrans (Fig. 135). ShrapnelVs membrane is composed of skin from the auditory canal, and of loose cellular tissue, covered by the mucous mem- brane of the tympanum, on its inner surface. Bridging a notch in the bony ring, the incisura Rivini, to which it is at- tached, it passes downward in front of the attic or upper cham- ber of the tympanum. Between Shrapnell's membrane and ANATOMY OF THE EAR 317 the neck of the malleus is a pouch or space called "Prussak's space," which sometimes becomes distended with pus during attacks of acute catarrh of the middle ear. Under such cir- cumstances a puncture through Shrap- nell's membrane, just above the short process, will evacuate the pus contained in Prussak's space and relieve the pain. The membrana iribrans or membrana tensor is pearly white in color and is polished on its outer surface. It consists of three layers-a dermic, formed by a continuation of the skin of the auditory canal; a fibrous (membrana propria), consisting of fibers radiating from a point near the center to the circumference, and circular fibers, which are so numerous at the periphery as to form a dense ring around the attached margin of the membrana vibrans and a mucous layer continuous with the mucous mem- brane of the tympanum. The handle or manubrium of the Fig. 135.-Outer surface of the right membrana tym- pani: a, Membrana flaccida or Shrapnell's membrane; b, posterior fold; c, short proc- ess; D, incudostapedial artic- ulation; E, malleus handle; F, umbo; G, cone of light. Fig. 136.--Outer half of sagittal section of entire left middle ear: o, Anterior and p, posterior, pouches of von Troltsch; op, ostium pharyngeum tubae; te, Eusta- chian tube; it, isthmus tubas; mt, membrana tympani, with the malleus and incus and the chorda tympani nerve; n, attic or recessus epitympanicus; an, mastoid antrum; w, w, mastoid cells (Politzer). malleus is fixed between the radiating and circular fibers of the membrana propria. The outer surface of the drum-head faces downward, forward, and outward at an angle of 55 degrees 318 DISEASES OF THE NOSE, THROAT, AND EAR with the axis of the auditory canal. Its outer surface is con- cave. From above, the malleus handle may be seen extend- ing downward and somewhat backward from the tubercle, its short process, and ending near the center of the drum-head at a depression, the umbo. During life, when illuminated, the membrana tympani generally presents a triangular light spot or "cone of light," having its apex at the umbo and extending downward and forward to the periphery (Fig. 135). The mu- cous membrane of the inner surface of the drum-head is folded upon itself as it passes over the chorda tympani nerve, so that two pouches are formed, opening downward, one in front of and the other behind the manubrium (Fig. 136). Vessels of the Membrana Tympani.-The dermoid layer is supplied with arterioles by the deep auricular branch of the internal maxillary artery; the mucous membrane, by the tym- panic branches of the internal maxillary, internal carotid, and stylomastoid arteries. Nerves of the Membrana Tympani.-To the external layer are distributed filaments from the superficial branch of the fifth nerve, while the mucous layer is supplied by the tympanic plexus. The cavity of the tympanum is of irregular shape. It meas- ures about | inch anteroposteriorly,| inch vertically, and I inch transversely. It is situated in the petrous portion of the tem- poral bone above the jugular fossa, having the catroid canal in front, the mastoid cells behind, the auditory canal externally, and the labyrinth internally. It communicates with the phar- ynx by means of the Eustachian tube and with the mastoid antrum by means of the aditus ad antrum. The upper portion of the tympanum is called the attic or recessus epitympanicus. It extends outward over the auditory meatus, from which it is separated by a wedge-shaped mass of bone, sometimes called the scute. On the scute lie the head of the malleus and body of the incus. The handle of the malleus and long process of the incus descend through the narrow opening from the attic into the atrium or lower cavity of the tympanum. ANATOMY OF THE EAR 319 The roof of the tympanum consists of a thin plate of bone, the tegmen tympani, which separates the tympanic cavity from the meninges of the brain. The floor of the tympanum is nar- Figs. 137 and 138.-Sections through the tympanum parallel to its inner wall: median aspect of the specimens: H, Horizontal semicircular canal; H.N, horizontal portion of aquaeductus Fallopii; V.N, vertical portion. In the upper specimen the section is somewhat more median than in the lower, in order to open the horizontal semicircular canal of the aquaeductus Fallopii. It will be observed that in the lower specimen, the tubercle, H, containing the semicircular canal is more lateral than the hard ridges of the bones below it, HN, containing the facial canal. In the upper specimen the stapes is in the oval window, and the topography of the inner wall of the tympanum, the aditus, and the mastoid antrum is well shown in both specimens (Author's specimens). row and separates the cavity of the tympanum from the jugu- lar fossa beneath. Nearer the inner wall is a small foramen for the passage of Jacobson -s nerve. The outer wall consists of 320 DISEASES OF THE NOSE, THROAT, AND EAR the membrana tympani and the bony ring into which it is in- serted. In this bony ring, the annulus tympanicus, are two small orifices, the iter chordae posterius and iter chodae anterius, for the entrance and exit of the chorda tympani nerve. Just in front of and above this bony ring is the Glaserian fissure, in which is lodged the long process of the malleus, and which also gives passage to some tympanic vessels and the anterior liga- ment of the malleus. The inner tympanic wall (Figs. 137 and 138), which is nearly vertical, bulges outward as an eminence, the promon- tory corresponding to the first turn of the cochlea. Below, posteriorly, is the niche, at the bottom of which lies the fenestra rotunda or "round window," closed by the mem- brana tympani secundaria. This mem- brane is protected by the external wall of the niche, in which it so lies that it is impossible to injure it by means of a straight instrument thrust from with- out through the membrana tympani. Above, posteriorly, is the fenestra ovalis or " oval window," closed by the foot-plate of the stapes. Above the oval win- dow is the eminence of the aqueductus Fallopii, which trans- mits the facial nerve. The pyramid is a hollow conic pro- jection containing the stapedius, muscle, whose tendon escapes by an opening at its summit. In the posterior wall above is the opening into the mastoid antrum, the aditus ad antrum. The anterior wall separates the cavity of the tympanum from the carotid canal, which lies immediately below and in front of it. In the upper por- tion of the anterior wall is the orifice of the Eustachian tube. Just above is the canal for the tensor tympani muscle. The Eustachian tube is separated from the canal for tensor tym- pani muscle by a thin bony plate, the processus cochleariformis. The ossicles are three small bones so arranged as to form a movable chain connecting the membrana tympani with the Fig. 139.-The malleus, incus, and stapes of left ear: A, Malleus; B, incus; C, stapes. ANATOMY OF THE EAR 321 fenestra ovalis. These three bonelets are the malleus or ham- mer; the incus or anvil; and the stapes or stirrup (Fig. 139). The malleus is a somewhat irregularly shaped bone, con- sisting of an oval head, articulating with the incus; a neck, a short and long process; and a manubrium or handle, imbedded in the membrana tympani. The head and neck of the mal- leus, which project into the tympanic cavity, are entirely free from the membrana tympani, the surface of the head, which articulates with the incus, being directed backward. The long and short processes are situated at the junction of Fig. 140.-Ligamentous support of ossicles, viewed from above: l-h, Attach- ment of the ligamentum mallei externum; k, head of hammer; i, body of incus; f, point of its short process; a, entrance to the Eustachian tube from the tympanum; c, stapes; d, tendon of stapedius muscle; b, tendon of the tensor tympani leaving the cochlear process; g-g, chorda tympani, marking the free edge of the folds of mucous membrane bounding the pouches; n, the upper tendinous fibers of the ligamentum mallei anterius, originating above the spina tympanica major, tn; j, malleo-incudal joint (Helmholtz). the neck and handle of the malleus. The short process pushes the membrana tympani outward before it and is gen- erally plainly visible during life as a tubercle at the upper extremity of the malleus handle. The long process passes forward into the Glaserian fissure, with the under wall of which it unites in adult life. The malleus is held in position within the tympanum by four ligaments-the anterior, su- perior, external, and posterior. Of these ligaments the anterior is by far the strongest, the posterior and external ligaments being, in a mechanical sense, but one ligament, to which Helmholtz has given the name "axial ligament of the malleus." 322 DISEASES OF THE NOSE, THROAT, AND EAR The incus is the middle one of the three ossicles, its name being derived from the shape of its upper part. This bonelet consists of a body, a short or horizontal process, and a long or descending process. The incus is attached at the extrem- ity of its horizontal process to the posterior tympanic wall by somewhat weak ligaments (Fig. 140). The long process of the incus curves downward, and at first somewhat outward, toward the auditory meatus, its tip bending sharply inward to articulate with the head of the stapes by means of the lenticular process. The malleo-incudal joint is a ginglymus or hinge-joint, like that of the knee or elbow. The ligaments of the malleus are so arranged that the bone performs the part of a lever whose fulcrum is just below the short process. The manubrium is the long arm of the lever and, consequently, all its movements are repeated in an opposite direction by the head of the malleus. Each inward movement of the membrana tympani and manu- brium causes a slight outward movement of the head of the malleus. The incus being also suspended as a lever, when its upper part moves outward with the head of the malleus its long process swings inward and pushes the stapes before it, so that the foot-plate is forced into the oval window. The stapes is the smallest bone in the body. It consists of a head, articulating with the lenticular process of the incus, two branches, or crura, joining the base, which is connected by ligamentous fibers with the margin of the oval window. The stapes (Fig. 139, C) measures 4 mm. from its head to the foot- plate, the latter measuring 2| mm. in its horizontal diameter. The foot-plate of the stapes is somewhat kidney shaped. When in position its long axis is nearly horizontal, with its convex edge looking upward and its concave edge looking downward. A thin membrane, the ligamentum obturatorium stapedius, stretches across the space between the base and the crura. Muscles of the Tympanum.-The tensor tympani originates from the under surface of the petrous bone, the cartilaginous ANATOMY OF THE EAR 323 Eustachian tube, and its own osseous canal. It is inserted into the handle of the malleus near its root. Its action is to draw the membrana inward and increase its tension. The tensor tympani muscle is supplied by a nerve from the otic ganglion. The laxator tympani major and minor have already been described as anterior and posterior ligaments of the malleus. The stapedius muscle originates from the interior of the pyramid and is inserted into the head of the stapes. Its action is to lift the anterior part of the foot-plate of the stapes out of the oval window, thus antagonizing to a certain extent the action of the tensor tympani muscle. The stapedius obtains its nerve supply by a filament of the facial nerve. Arteries of the Tympanum.-The tympanic branch of the in- ternal maxillary enters the Glaserian fissure and is distributed to the membrana tympani. The tympanic branch of the in- ternal carotid also supplies the membrana tympani. The stylomastoid extends from the posterior auricular to the back part of the tympanum and mastoid cells. The petrosal artery-a branch of the middle meningeal, enters the ear through the haitus Fallopii, and a branch from the ascending pharyngeal passes up the Eustachian tube. Nerves of the Tympanum.-The tympanic branch of the glosso-pharyngeal (Jacobson's nerve) supplies the mucous mem- brane of the tympanum and fenestrae. The tympanic branch of the facial nerve supplies the stapedius muscle and a branch from the otic ganglion supplies the tensor tympani muscle. The chorda tympani nerve passes across the tympanum be- tween the handle of the malleus and the long process of the incus, without branches. It enters the tympanum by the iter chordae posterius and emerges through the iter chordae anterius. The Tympanic Plexus.-Jacobson's nerve (tympanic branch of the glossopharyngeal) divides into three branches, lying in grooves upon the promontory: One joins the carotid plexus; a second, the greater superficial petrosal nerve; and a third, passing upward and forward, finally becomes the lesser super- ficial petrosal nerve. 324 DISEASES OF THE NOSE, THROAT, AND EAR The Eustachian tube, which is about i| inches long, passes from the middle ear downward, forward, and inward to enter the pharynx. It affords communication between the air in the pharynx and that contained in the middle ear. The outer third consists of bone, commencing at the anterior tympanic wall, and gradually narrowing to terminate at the angle of junction of the petrous and squamous portions of the temporal bones. The inner two-thirds of the Eustachian tube consist of elastic cartilage and fibrous tissue, which unite the inferior portion of a curved cartilaginous plate so as to form a tube. The mucous membrane lining the Eustachian tube is a con- tinuation of that of the pharynx and is covered with stratified ciliated epithelium. At birth the Eustachian tube is nearly horizontal with its pharyngeal orifice at the level of the hard palate, until about the ninth month, when it is distinctyl higher. At about this age the tube also begins to slant some- what upward and outward. During infancy the tube is wider at its narrowest point than in the adult. The muscles that dilate the Eustachian tube are the levator palati muscle, which, arising from the petrous bone and carti- laginous portion of the tube, is inserted into the tissues of the soft palate, and the tensor palati, a flattened muscle, which, arising from the sphenoid bone and the cartilaginous tube, passes as a broad tendon around the hamular process to form the broad aponeurosis of the soft palate. The action of both these muscles is to dilate the tube. Some of the fibers of the tensor tympani and tensor palati are blended and an aponeu- rotic connection always exists along the Eustachian tube, so that probably these two muscles have no action entirely independent of each other. When the soft palate is drawn upward the membrane is also retracted by the tensor tympani and the Eustachian tube is at the same time dilated, so that, although a current of air enters the tympanum, it is prevented from forcing the membrane too far outward and interfering with the equilibrium of auditory tension. The tensor tympani and tensor palati receive nerve-filaments from the otic ganglion, ANATOMY OF THE EAR 325 but the levator palati is supplied by a branch from Meckel's ganglion. The Eustachian tube receives its arterial supply by the fol- lowing arteries: The ascending pharyngeal, branches from the middle meningeal and internal maxillary, and a branch from the stylomastoid artery. Its nerves are, in addition to those supplying muscles of the tube, derived from the fifth and seventh pair and the glosso- pharyngeal. The Mastoid Process of the Temporal Bone.-At birth the mastoid process consists of a small flattened tuberosity con- taining but one cell and that of considerable size-the mastoid antrum (Fig. 193). At puberty the mastoid process has be- come a distinct prominence, conic in shape, with its apex downward. The substance of the mastoid process consists of small cavities varying greatly in number, size, and shape in different individuals. Some of them communicate with each other and are lined with a continuation of the mucous mem- brane of the tympanum, which is here covered by squamous epithelium. THE INTERNAL EAR OR LABYRINTH Osseous Boundaries.-At all points the various channels and cavities of the labyrinth are deeply imbedded in the petrous portion of the temporal bone. The bony labyrinth consists of a central cavity called the "vestibule," from the walls of which spring, like arches, the semicircular canals, while through the anterior wall of the vestibule a canal leads into the snail- shaped cavity of the cochlea (Fig. 141). Contents of the Osseous Labyrinth.-The vestibule contains fluid and two distinct membranous sacs, the utricle and saccule (Fig. 142). The saccule communicates with one of the mem- branous tubes of the cochlea, the ductus cochlearis, by means of a slender membranous tube, the canalis reuniens, while the cavity of the utricle is continuous with that of the mem- 326 DISEASES OF THE NOSE, THROAT, AND EAR branous semicircular canals, so that the membranous labyrinth may be said to consist of a system of cavities with membran- Fig. 141.-The bony labyrinth laid open by removal of lateral wall: I, Recessus ellipticus for utricle; 2, recessus sphasricus for saccule; 3, recessus cochlea; 4, pyramus vestibuli; 5, round window; 6, posterior semicircular canal; 7, external semicircular canal; 8, cupola of the cochlea; 9, superior semicircular canal; 10, lamina spiralis ossea projecting from the modiolus into the caliber of the canal of the cochlea, and terminating in the cupola as a hook-like process called the "hamulus." ous walls containing a fluid, the endolymph, and nearly sur- rounded by another fluid, the perilymph. A diaphragm consisting partly of bone (lamina spiralis ossea) ^Macula acus- lica saccuiu „Sacculus. „Utriculosac- cular canal. -Macula acus- tica utriculi. -Ampulla, ■Ant. semicircular canal. Auditory nerve with its vestibu- Jar and cochlear branches. Ampulla. zUtriculus. Post, semicircular canal. Fig. 142.-Membranous labyrinth of the right ear from five-months'-old human embryo (from Schwalbe, after Retzius). Cochlear duct. Canalis reuniens. Ductus endolvmohaticus Ampulla. Horizontal semicir- cular canal. and partly of membrane (membrana basilaris) divides the cavity of the cochlea into an upper and lower space of nearly equal size (Fig. 143). The upper, the scala vestibuli, com- ANATOMY OF THE EAR 327 municates with the cavity of the vestibule, and the lower, the scala tympani ends abruptly at the round window. The upper Fig. 143.-Longitudinal section of the cochlea, showing the relations. of the seal®, the ganglion spirale, etc.: S.V, Scala vestibuli; S.T, scala tympani; S.M, scala media; L.S, ligamentum spirale; G.S, ganglion spirale (Gray). space (scala vestibuli) is divided by a diaphragm (Reissner's membrane) placed at an angle of 45 degrees with the mem- brana basilaris, into the scala vestibuli proper and the scala Fig. 144.-Transverse vertical section of Corti's organ of a man twenty-nine years old; es, Limbus laminse spiralis; me, membrana tectoria; Hb, Hensen's striae; mf, fibers of attachment of the membrana tectoria to the zona tecta; si, sulcus spiralis; siz, epithelium of the sulcus spiralis; is, inner supporting cells; ic, inner rod cells in connection with the outer rod cells, between which is seen the tunnel (7) of Corti; ih, inner hair-cell; ah'-ah*, outer hair-cells; dz, Deiters' cells; (is, Hensen's supporting cells; rb, nerve-fibers of the ramulus basilaris; w'-w6, outer bundles of the spiral nerve-fibers; rf, radiating tunnel, fibers; at, inner part of Nuel's space; mb, upper layer of the membrana basilaris; mb', lower layer of the membrana basilaris; tb, layer covering the tympanic surface of the membrana basilaris; Us, ligamentum spirale (Gruber, after Retzius). media or ductus cochlearis, which, as already described (Fig. 142), communicates with the saccule by means of the canalis 328 DISEASES OF THE NOSE, THROAT, AND EAR reuniens. The sacla media or ductus cochlearis contains endolymph and the organ of Corti (Fig. 144). The organ of Corti rests upon the membrana basilaris about midway between the lamina spiralis ossea and the outer wall of the ductus cochlearis. It extends from the vestibule to the cupola of the cochlea, and to it are distributed nerve-fibers from the cochlear branch of the auditory nerve. Corti's organ is made up of a nearly central arch, formed by the inner and outer rods or pillars of Corti (Fig. 144), the bases of which are farther apart as the organ of Corti ascends from the vestibule to the cupola. There are at the outside of the arch four rows of ciliated cells and at the inner side one row, which receive terminal fila- ments from the cochlear branch of the auditory nerve. The name "hearing cells" is sometimes ap- plied to these hair-cells. There is a peculiar fenestrated membrane, the lamina reticularis, into whose net-like structure project the cilia of the outer hearing cells, which are covered and protected by a glue-like substance, the membrana tectoria. The rods of Corti have been estimated at about 10,500, while the number of hair-cells is estimated to be about 21,300. The membranous semicircular canals occupy scarcely one- third of the space inside the bony canals, except at the ampullae, where they hug the bony walls more closely. The space be- tween the membranous canals and the bony wall is occupied by connective tissue rich in blood-vessels rather than with free fluid, as in the cochlea (Fig. 145). The otoliths are granular, amorphous, sometimes crystal- line particles found along the walls of the utricle, saccule, am- Fig. 145.-Section through the osseous and membranous semicirct^* lar canals: a, Osseous semicircular canal; b, place of attachment of the membranous semicircular canal; c, elevations on the inner surface of the membranous semicircular canal; d, vascular bands of connective tissue (Poiitzer). ANATOMY OF THE EAR 329 pullae, membranous canals, on the periosteum of the osseous semicircular canals, and in the fluid of the cochlea. They con- sist of about 75 per cent, mineral matter, mostly carbonate of lime, and organic material resembling mucous in its physical and chemic characteristics. In some of the lower animals they are huge in size compared with those of man and assume fantastic shapes. The auditory nerve originates by three fasiculse from the superior vermiform process of the cerebellum and from the in- ner and outer nuclei, formed chiefly by the gray substance of the posterior pyramid and restiform body. The nerve emerges, superfically, from a groove between the olivary and restiform bodies at the lower border of the pons. At the bottom of the internal auditory canal it divides into the cochlear and ves- tibular divisions, both of which contain ganglion cells. The cochlear nerve divides into numerous filaments to enter the modiolus and sends branches to each of the hair-cells (Fig. 144). The vestibular nerve divides into three branches: The filaments from the upper branch enter the vestibule through the macula cribrosa at the bottom of the internal meatus, and are distrib- uted to the utricle and the ampulla of the external and superior semicircular canals; the middle branch is distributed to the saccule, and the inferior branch passes to the ampulla of the posterior semicircular canals. Function of Vestibular Apparatus including the Semicircular Canals.-They are peripheral space-organs, and through centers in the brain regulate the movements of the muscles of the eye and probably all the muscles of the body for the preservation of equilibrium. The power of maintaining equilibrium is de- rived from the education of touch and sight and information derived from the peripheral space-organ within the ear, which informs the brain of the position of the head and regulates the movements of the muscles for the preservation of equilibrium. Function of the Cochlea.-The cochlea has to do with the sense of hearing. It is supposed that the individual hair- cells and rods of Corti vibrate to single tones, and that a 330 DISEASES OF THE NOSE, THROAT, AND EAR compound sound causes the vibration of a number of hair- cells proportionate to its composite character. TESTS FOR HEARING Hearing is the faculty of the perception of sound. Sound is a peculiar sensation excited in the organs of hear- ing by the vibratory motion of bodies, the effects of which are transmitted to the ear through an elastic medium. Sound is a sensation and should be distinguished carefully from the vibrations that produce it; which vibrations, of course, may exist without the presence of an organized being to per- ceive them. Sources of Sound.-Sound is produced by the rapid vibra- tions that take place in the molecules of bodies when they are disturbed by shock or by friction. When a resonant body is struck its molecules alternately approach and recede from one another with a velocity and amplitude of vibrations corre- sponding to the form, size, and molecular composition of the body; and this motion is transmitted by contact to any surrounding elastic medium, such as air. Sound-waves so produced are in part reflected in passing from a rarer to a denser medium, as, for example, when passing from air into water. If, however, a tense membrane, free to vibrate, is interposed between the air and any fluid or solid medium, the aerial vibrations are not reflected, but are transmitted into the more solid medium with little loss of their intensity. But for the membranes of the middle ear, sound-waves trans- mitted from the ear to the lymph of the labyrinth would lose intensity to such a degree as to be inaudible. Acoustics is that department of physics which treats of sounds. A rudimentary knowledge of the laws of acoustics is essential to an understanding of the physiology of the ear. The science of music treats of a peculiar class of sounds and combination of sounds calculated to produce pleasurable emotions. Such sounds are distinguished from noises, which ANATOMY OF THE EAR 331 are sounds either of very short duration, like the reports of fire- arms, or are a mixture of many discordant sounds. Pendulum Vibration.-If a needle be attached to one arm of a vibrating tuning-fork, and if in contact with the end of the needle a piece of smoked paper be moved at a uniform velocity, a tracing of the vibrations of the needle will be scratched upon the paper (Fig. 146). This tracing is a record of the number of vibrations of the fork during a given time and of the amplitude of the vibrations. The record is regular and uniform, and so similar to that produced by a pendulum under similar circum- stances that Huxley has described this form of vibration under the name of pendulum vibration. A tone is a sound produced by a simple pendulum vibration. It has the characteristics of quality or "timbre"; intensity, volume or loudness; and pitch (high or low tone). The quality of a tone depends largely upon the material of the Fig. 146.-Tracing on smoked paper produced by the vibrations of a tuning-fork. substance which produces the tone. The quality of the note emitted by striking a strip of wood is entirely different as regards its quality or "timbre" from that produced by striking a rod of metal. A note produced from an organ, a violin, and a cornet may in each case have the same pitch and volume, but will differ widely from one another as regards quality or timbre. The intensity of a tone depends upon the force and amplitude of the vibrations which produce it. When a tuning-fork is first made to vibrate, its tone is comparatively intense or loud, because the force and amplitude of its vibrations are compara- tively great, but as it continues to vibrate its tone is heard less and less distinctly, because the force and amplitude of its vibra- 332 DISEASES OE THE NOSE, THROAT, AND EAR tions are becoming less and less. The pitch of the tone, however, remains the same until the fork ceases to vibrate. The pitch of a tone depends upon the rapidity of the vibra- tions that produce it. The more rapid the vibrations, the higher the pitch. The human ear is generally able to distin- guish the tone produced by a tuning-fork vibrating only 16 times during a second, and also that of a fork vibrating 38,000 times a second. The capacity, however, to distinguish sounds of very low or very high pitch varies greatly in individuals, but the ears of most persons are more sensitive to sounds of low than to those of high pitch. The inability to hear high notes increases with age, and generally also as the result of disease of the labyrinth or acous- Fig. 147.-The Edelmann-Galton whistle with rubber bulb. The pipe below the opening is filled with a plunger advanced or withdrawn by a screw, each turn being shown by the scale upon the enlarged tube, and its tenths by that on the revolving collar. It gives an audible sound from 0.5 (theoretically, 84,000 v. s.) to 10 or 12 (4200 or 3500). tic nerve; and in testing the acuteness of hearing by means of tuning-forks and the Edelmann-Galton whistle it is well to bear this fact in mind. For careful tests as to the sensitiveness of the perceptive apparatus it is well for the aurist to be pro- vided with at least five forks, the lowest (c-2) giving 32 vibra- tions during a second and the highest (C4) yielding 2048 vibrations in a second. The Edelmann-Galton whistle (Fig. 147) is used also for making tests of this kind. The Edelmann-Galton whistle, for testing the higher tones of the scale, consists of a metal tube so perforated as to cause a whistle when air is blown through it by means of a rubber bulb. The distal extremity is closed by a metal rod capable of being moved backward and forward within the tube by a ANATOMY OF THE EAR 333 micrometer screw. The length of the column of air within the tube beyond the perforation, and consequently the pitch of the note emitted by the whistle, are determined by the posi- tion of the rod within the tube. The micrometer screw is graduated to indicate single numbers, while on the side of the tube is a scale to show tens; so that by turning the micrometer screw the metal rod within the hollow cylinder can be placed in any position indicated by a number on the scale. The pitch of the whistle notes have a range of from about 7000 to 80,000 vibrations. Helmholtz states that the human ear is able to distinguish as musical notes tones lying between 16 and 38,000 vibrations per second, or a range of about 11 octaves, but that the lowest note used in orchestral music is E-2 or one of 40 vibrations per second. In pianos the lowest note in general use is C-2, 32 vibrations per second; and the highest, 7 octaves above it, is c5, 4096 vibrations during a second. Harmony.-If the rates of vibration in a second of two notes simultaneously produced stand to each other in the ratio of simple multiples, so that while the low note makes 1 vibration the high note makes 2, 3, 4, etc., the notes are said to be in harmony or concord, as the result is consonance. These are the ratios of the human voice in ordinary speaking or singing, and, according to Wolf, speech has a compass of 5 octaves, from c to c5. The simplest ratio is f, and to this the name octave is given. In this case the higher note has double the number of vibrations of the lower. The ratio of the notes in the diatomic major scale is as follows: c. D. E. F. G. A. B. C 9 5 4 3 5 1 5 1 I K J 7 ■J -r 2 The tuning-fork used to test the hearing should be large enough to secure sufficient intensity or loudness of tone. It is desirable to have the tuning-fork provided with movable clamps, so as to deaden overtones. While it is more con- venient, as stated, for the aurist to be provided with at least 334 DISEASES OF THE NOSE, THROAT, AND EAR five or more forks of different pitch, yet one sounding the note C (256 vibrations per second) is the most useful for ordinary clinical investigations. It is convenient to have at hand a small tuning-fork emitting a tone of feeble intensity in order to confine the sound to one ear; because when a very heavy tuning-fork is employed in examining patients whose hearing is greatly impaired only in one ear, it is impossible to be certain that the sound of a large fork is not heard by the ear in which the hearing is better. However, a large fork, provided with movable clamps, can generally be made to answer the same purpose by placing the clamps sufficiently low down upon the tines of the instrument. When it is necessary to be certain that no sound is heard by the ear not being examined, a noise apparatus should be con- nected with it in such a manner that other sounds cannot be heard by it. Weber's Testr-Any obstruction to the exit of sound- waves from the middle ear when a tuning-fork is vibrating with its handle in contact with the teeth or at a point upon the cranium midway between each ear, will cause the sound of the fork to be heard most distinctly in the obstructed ear. The cause of the obstruction may be impacted cerumen in the external auditory meatus, occlusion of the Eustachian tube, mucus within the tympanum, or thickening of the membrana tympani as the result of catarrh of the middle ear. Hence, if a patient is deaf in only one ear from any of these causes, a vibrating tuning-fork, with its handle in contact with the teeth or on a point on the cranium midway between the ears, will be heard by him better in the deaf ear. If, however, the hard- ness of hearing is due to impairment of the labyrinth or the auditory nerve, the note of the tuning-fork will be heard less distinctly in the deaf ear. Weber's test is most reliable in cases of unilateral tympanic disease, less so in labyrinthine disease and in bilateral chronic middle-ear catarrh. In practising Weber's method of examining the hearing, the observer should bear in mind that the answers of some patients ANATOMY OF THE EAR 335 are largely determined by their imagination, and that they will say at first that they hear the sound of the fork most distinctly in that ear in which the hearing is better simply because they think they should do so. The test should be repeated sufficiently often to convince the observer that his patient's answers are reliable. It will, in all instances, be judicious to request the patient, while the fork is still vibrating upon the cranium, to close first one ear and then the other with a finger, and only after this has been done to ask him in which ear he now hears the sound of the fork most distinctly. Rinne's Test.-Rinne observed that when a vibrating tun- ing-fork, with its handle in contact with the tissues over the mastoid process, ceased to be heard, the sound of the fork reap- peared if it was held in front of the ear; the C2 fork is usually heard about twice as long. Aerial conduction is superior to tissue-conduction in individuals with normal ears. If the tuning- fork is heard best by aerial conduction, the fact may be noted as Rinne+; or Rinne- if the contrary is the case; or, to be more exact, the number of seconds that the tuning-fork is heard upon the mastoid and in front of the auditory meatus may be given in the form of a fraction, the numerator of which will be less than the denominator if Rinne's method yields a positive result, and the contrary will be the case if Rinne's method gives a negative result. Thus, if a note of a C2 tuning- fork whose handle is in contact with the mastoid process is heard for twenty seconds, and for fifty seconds when its tines are held close to the external auditory meatus, the fact may be noted thus: Rinne If, however, the fork is heard for thirty seconds when its handle is in contact with the tissues over the mastoid process, and only ten seconds when its prongs are held close to the meatus, the fact should be noted as Rinne - (R. - 1^). In the first instance any hardness of hearing is due to impairment of the nervous part of the ear; in the latter case it is due to the result of disease or to imperfection of the exter- nal or middle ear, or both. It is a well-known fact that any rigidity of the conducting 336 DISEASES OF THE NOSE, THROAT, AND EAR apparatus so alters the relation of tissue to aerial conduction that the former finally exceeds the latter. This change begins with the low notes. If Rinne's method be employed on a patient in whom there is only a slight impairment of the patency of the Eustachian tubes, with congestion of the mucous mem- brane of the tympanum, the result will be negative with forks emitting a very low-pitched note and positive for that of a higher pitch. That is, the sound of the fork of low pitch will be heard louder and longer when its handle is firmly pressed upon the mastoid process than when the tines of the fork are held in front of the meatus. This, however, will not be the case if a fork emitting a high-pitched tone be employed. In con- ditions in which there is great rigidity of the transmitting ap- paratus of the ear, the receptive apparatus remaining healthy, Rinne's test will yield a negative result with forks of high as well as low pitch. Generally under such circumstances tissue- conduction will be apparently increased; that is, a tuning-fork with its handle pressed upon the tissues over the mastoid will be heard louder and longer than normal. When, instead of this being the case, tissue-conduction as well as aerial conduc- tion is decreased, impairment of the functions of the internal ear should be suspected, although it should be borne in mind, when testing the hearing of patients past middle life, that tissue-conduction of sound is always decreased as the result of senility, and sometimes as the result of other causes besides disease of the internal ear. It also should be borne in mind that in unilateral nerve deafness Rinne's test is frequently negative because the sound of the fork by tissue-conduction is transmitted from the mastoid of the diseased ear to the normal as well as the diseased ear unless a noise apparatus is used. The test is only reliable when hearing for whispers is reduced to i meter, and the more profound the deafness, the more reliable the test. It cannot be depended upon in old age. In any case, however, in which the acuteness of hearing is reduced to the perception of words spoken in a loud voice close to the ear, if tissue-conduction is greater than aerial conduction ANATOMY OF THE EAR 337 only for forks of low pitch (Cx to c), while those of high pitch (C3, C4) are heard very imperfectly if at all, either by aerial or tissue-conduction, the receptive apparatus, as well as the mid- dle ear, is impaired. In such cases, although the tension of the structures of the middle ear can doubtless be removed by operative procedures, the performing of such an operation will not result in a great improvement in the patient's hearing. In cases where middle-ear deafness can be excluded, defective hearing for high tones is suggestive of labyrinthine disease ff or low tones of disease of the central nervous system; for the mid- dle notes of the scale, of disease of the auditory nerve trunk. _ Schwabach's Test.-This test consists in comparing the number of seconds a fork is heard on the mastoid and at the meatus in a normal ear with the time the fork is heard in these positions by the ear being examined. The difference in time a patient hears a fork vibrating on his mastoid and the physi- cian hears it,is ascertained by the oscultation tube (Fig. 148), which connects the meati of observer and patient so that both hear the sound of the fork vibrating on the patient's mastoid. Gelle's Test (Pressions Centripetes}.-If the air within the auditory canal be compressed by means of Siegle's speculum or any suitable instrument, a normal ear will hear the sound of a tuning-fork vibrating on the cranial bones with diminished intensity. This phenomenon is due to increased labyrinthine pressure, because when the air within the auditory canal is con- densed the chain of bonelets with the foot-plate of the stapes is pressed inward. If ankylosis of the stapes exists or if there is great immobility of the ossicles the tone of the tuning-fork will remain unchanged during the test, while if the labyrinth is diseased and the stapes is movable the application of Gelle's test will produce dizziness. Bing's Test.-If a tuning-fork is vibrated upon the mastoid process of a normal ear, after its sound is no longer audible it can be made to reappear if the meatus is tightly closed with the moistened finger. In cases of severe deafness, according to 338 DISEASES OF THE NOSE, THROAT, AND EAR Bing, if this test yields a negative result, the hardness of hear- ing is due to a middle-ear affection, while if the result of the test is positive, the deafness is the consequence of a labyrinthine affection. Dr. Bing uses also, as an aid to diagnosis, what he terms the " entotic" use of the speaking-trumpet, which consists in speak- ing into the speaking-tube connected by means of an air-tight joint with a catheter introduced into the mouth of the Eustach- ian tube. If the voice is heard better by this method than when the speaking-tube is used in the external meatus, there is hindrance to sound-conduction at the malleus or the incus, and the foot-plate of the stapes is freely movable in the oval window. To test the hearing by a watch the patient should be seated with his face so covered by a napkin or towel that it is impos- sible for him to see the watch, because many patients imagine that they hear a watch which they see held close to their ear. It is well also to request the patient to close firmly with his forefinger the ear that is not being tested. The aurist should hold the watch in his hand with its case open close to the patient's ear until the latter hears it distinctly, then move his hand to a considerable distance and slowly bring the watch toward the ear being examined, observing the exact distance the watch is when^s/ heard. The result of the examination may be expressed by a fraction, the numerator of which is the distance at which the patient hears the watch and the denomi- nator the distance at which the watch can be heard by a nor- mal ear. For example, if the watch used in making the test is heard by a normal ear at 40 inches, and the patient hears it only at 15 inches, the fact may be recorded thus: Hearing for watch is H (H. W. - If the watch is heard only on contact with the auricle, the record should read, Hearing for watch is ; or, if it is only heard by exerting considerable pressure with it upon the auricle, Hearing for watch is pressure. 40 The room in which the hearing is being tested by the watch PATHOLOGIC CONDITIONS OF NOSE AND PHARYNX 339 should be as free from noise as possible, and the watch should invariably be made to approach the patient's ear from a dis- tance, as directed above, and the point be noted at which it is first heard, because, while the patient still hears the watch if it is slowly carried away from his ear, it will be found that he will continue to hear it at a much greater distance than that at which he would first hear it if it were made to approach his ear from a distance. The hearing may be tested in a similar man- ner by means of the acoumeter, an instrument devised by Politzer. The acoumeter gives the note c with about the same loudness as the sound of a loud-ticking watch. A stop watch is more convenient than an ordinary watch for testing the hearing. In testing the hearing by the voice the patient should close the ear not being tested firmly with his forefinger, and either close his eyes or look in such a direction that it will be impos- sible to see the motion of the aurist's lips; the distance in feet should then be observed at which words are heard when spoken in a whisper, ordinary conversational tone, or a loud voice if the patient be very deaf. In making this test of the hearing- power it is best, in most instances, to employ single words of only one syllable. The result of the examination may be noted as a fraction, the numerator of which is the distance in feet at which the patient hears the words and the denominator the distance in feet at which a normal ear can hear the same words. For example, if the patient hears whispered words 3 feet from his ear, and should hear them at 10 feet, the fact may be re- corded thus: Whisper tV PATHOLOGIC CONDITIONS OF NOSE AND PHARYNX CAUSING DISEASE OF EAR Anatomically the Eustachian tube, tympanum and mastoid cells are more closely related to the nasopharynx than the internal ear, being an extension from the oro-nasal cavity, an accessory sinus as a matter of fact of the nose; and only inci- 340 DISEASES OF THE NOSE, THROAT, AND EAR dentally related to the ear proper which is developed from a separate otocyst. The arterial, venous and lymphatic cir- culation of the middle ear are closely related to those of the nose and pharynx; and hence its pathology at least has its origin in most cases from a nasal or pharyngeal disease. As the result of chronic nasopharyngeal catarrh the Eusta- chian tubes and middle ear become affected in a proportion of cases. Especially if the catarrh be of the hypertrophic variety, so that nasal respiration is interfered with by the presence of anterior and posterior hypertrophies, ecchondroses or exostoses from the septum, etc., disease of the Eustachian tubes may result. The same is true of a deflection of the sep- tum sufficiently great to cause marked obstruction of one nos- tril. In many instances catarrh of the Eustachian tube and middle ear is the result of the extension by continuity of sur- face of a similar affection of the nasopharynx. However, when one or both nasal chambers are obstructed other causes probably bring about the same result. Posterior to the ob- struction, in nearly all cases of nasal stenosis, a partial vacuum is formed during inspiration; as the result, the nasal mucous membrane is constantly engorged with blood in this locality. This condition may extend back far enough to involve the pharyngeal mouth of the Eustachian tube. Probably most cases of one-sided deafness on the same side as an obstructed nostril may be explained in this manner. The hearing in such cases frequently improves rapidly after the removal of the nasal stenosis, but a posterior hypertrophy may be so situated as to produce venous stasis in that locality. By far the com- monest cause of Eustachian salpingitis, in children at least, is hypertrophy of the pharyngeal tonsil. When the adenoid overgrowth is situated so as to interfere with the return of blood from the mucous membrane of the Eustachian tubes, stenosis results because of engorgement and inflammation, and the hearing deteriorates more and more as the result of each succeeding attack of coryza. Under such circumstances, if the hypertrophy has not existed too long, a complete restora- PATHOLOGIC CONDITIONS OF NOSE AND PHARYNX 341 tion of the hearing may be expected to follow the removal of a portion of the hypertrophied gland. Occasionally cicatricial bands in Rosenmuller's fossa present the proper movement of the tube mouths and when present should be broken down. However, it must not be supposed that by removing the nasal disease which produced the aural affection a complete restora- tion of the hearing will result in every instance. In most cases of this kind careful treatment of the tubal or middle-ear dis- ease is absolutely necessary. The pharyngeal mouths of the Eustachian tubes, bordered by their cartilaginous lips, appear as crater-shaped elevations in front of Rosenmuller's fossa. The mucous membrane at the entrance of the tube is, in the normal state, paler than that in its vicinity, which is of a deep-red color over the cartilaginous lips which may be congested, anemic, hypertrophied with or without lymphoid excrescences, atrophic with or without mucus or crusts protruding from them and perhaps overhung by ade- noid tissue from the fossa of Rosenmuller. . The tube mouths may be inspected either by posterior rhinoscopy or with the nasopharyngbscope, by means of which not only the patho- logic condition of the tubal mucous membrane but also the movements of the tube mouths can be seen. Patency of Eustachian Tubes.-The methods most com- monly used to test the patency of the Eustachian tubes and introduce air into the middle ear are Valsalva's, Politzer's, and catheterization of the Eustachian tubes. Valsalva's method consists in a forced expiration, the mouth and nose being closed. In this method air is forced from the pharynx through the Eustachian tubes into the middle ear. If the aurist examines the membrana tympani while the patient inflates the middle ear by Valsalva's method the drum-head will be observed to move outward, and in most instances it will become slightly congested. If an aural stethoscope be used, a slight noise will be heard as the air enters the patient's middle ear. The aural stethoscope or auscultation-tube consists of about 342 DISEASES OF THE NOSE, THROAT, AND EAR 3 feet of thin rubber tubing, into the ends of which appropriate ear-pieces are inserted. One ear-piece should be of white bone for the aurist's own ear, and the other end of hard rubber, to be inserted into the auditory canals of his patient's ears. In Politzer's method the patient is directed to hold a small quantity of water in his mouth until he is told to swallow. The aurist then takes the nose-piece of Politzer's air-bag (Fig. 149) between his thumb and finger and inserts it into one of the patient's nostrils, and closes both nostrils firmly about the nose- piece by pressure with his middle finger and forefinger. The patient is then told to swallow; as the patient's larynx is seen to rise at the commencement of the act of swallowing the aurist Fig. 148.-Toynbee's auscultation-tube. quickly compresses the air-bag held in his right hand, thus forcing air through the nose and Eustachian tubes into the mid- dle ear. If the auscultation-tube is used during this procedure, the air will be heard to enter the middle ear with the same audi- ble click observed when Valsalva's method of inflating the mid- dle ear is employed. During the act of swallowing the soft palate rises, thus cut- ting off all communication between the posterior nasal chamber and the mouth, and at the same time the Eustachian tubes are rendered more patulous by the action of the levator palati and other muscles, so that air forced into the nose by Politzer's method, having no other way of exit, readily finds its way into the middle ear through the tubes. The same thing may be accomplished with greater convenience by requesting the PATHOLOGIC CONDITIONS OF NOSE AND PHARYNX 343 patient to "puff out his cheeks" and compressing the air-bag while the mouth is thus inflated with air. Pronouncing cer- tain syllables, like the words hick, hack, hock, also causes an elevation of the soft palate and a dilatation of the Eustachian tubes, so that the middle ear can readily be inflated by means of Politzer's air-bag. The middle ear of young children is usually more easily inflated by means of Politzer's air-bag than those of adults, while in the case of infants air readily enters the middle ear if Politzer's air- bag be used while the child is crying. No more force should ever be employed in compressing the rubber bag than is absolutely necessary to force air into the middle ear, and it is far better for the aurist to make several unsuccessful efforts to accom- plish this purpose than to drive air into the middle ear with sufficient force to cause pain. It is probably impossible to rupture a normal membrana tympani with Politzer's air- bag, but atrophied or diseased drum-membranes have been ruptured by the incautious use of this instrument. The Eustachian catheter is a tube of rubber or metal curved at its distal extremity, as shown in Fig. 150. The proximal end of the instrument is so constructed that the nozzle of Politzer's air-bag will fit loosely into it, and it is provided with a ring or mark of some sort by which the aurist is informed of the position of the beak of the instrument when it has been inserted in the nose. At least three sizes of this catheter should be in possession of the aurist-'respectively 1, 2, and 3 milli- meters in diameter. The hard-rubber catheters have the Fig. 149.-Politzer's air-bag 344 DISEASES OF THE NOSE, THROAT, AND EAR advantage of cheapness, but they are not so easily disinfected as are the metal ones, which can be dropped into water and boiled or sterilized by pouring some alcohol over them and setting it on fire. Moreover, the hard-rubber instruments have a diameter larger in proportion to the size of their caliber than that of the silver catheters. The best catheters are made of pure or, as it sometimes is called, "virgin" (in contradis- tinction to "coin") silver, which insures a certain degree of flexibility. The cheap brass, nickel, or silver-plated instru- ments are clumsy, and are so hard, brittle, and inflexible that the curve of the beak cannot be slightly changed readily, as in the case of the softer pure silver instruments. The distal extremity should be slightly knobbed, smooth, and round. What is known as Hartmann's catheter is probably the best model (Fig. 150). Fig. 150.-Hartmann's silver Eustachian catheter. Introduction of the Beak of the Catheter into the Eustachian Tube.-'The operator should first inspect the anterior narium and note the position, size, and shape of any obstruction, such as a septal exostosis, which will interfere with the passage of the catheter. The operator should hold the proximal extrem- ity of the catheter between the thumb and fingers of his right hand, somewhat in the manner of a penholder, and lift up the tip of the patient's nose with the thumb of his left hand. The beak or distal extremity of the catheter is then inserted within the nares and is made to rest upon the floor of the nose, while the proximal end of the instrument is elevated until it is parallel with the floor of the nose. Still keeping the beak of the instru- ment in contact with the floor of the nose, the catheter is pushed gently inward until the beak of the instrument is felt to be in contact with the posterior wall of the pharynx. At this stage PATHOLOGIC CONDITIONS OP NOSE AND PHARYNX 345 the operator has the choice of the three methods of procedure in common use. Probably the one most frequently employed is that of Ldwen- burg, who directs that when the beak of the instrument is felt to be in contact with the pharyngeal wall the catheter should be rotated medianly through an angle of 45 degrees, and drawn forward until the beak of the instrument is felt to touch the posterior edge of the septum, when it is rotated outward through rather more than an angle of 90 degrees, and should then be in the mouth of the Eustachian tube. The operator may feel satisfied that this is the case if the beak of the catheter is found to be somewhat firmly fixed in the position it has assumed, so that it is impossible to rotate the beak of the instrument upward or carry it backward or forward without exerting considerable force. Gruber directs that when the beak of the catheter is felt to be in contact with the pharyngeal wall it should be withdrawn until its curved portion comes into contact with the posterior margin of the hard palate. It should then be again pushed inward a distance of about J inch, and rotated outward toward the ear through an angle of a little more than 45 degrees, when, if these maneuvers have been successful, the beak of the instru- ment will be within the mouth of the Eustachian tube. When the beak of the instrument is felt to be in contact with the pharyngeal wall it may be immediately rotated outward 45 degrees, which will carry the beak of the instrument into Rosen- muller's fossa. The catheter should now be drawn gently out- ward until its beak is felt to slip over the posterior lip and into the mouth of the tube. An operator soon learns by the sensa- tion imparted to his hand whether the beak of the instrument is or is not in the Eustachian tube. Obstacles to Catheterization of the Eustachian Tubes.-'Devia- tion of the septum may render the passage of a Eustachian catheter through that side of the nose impossible. Under such circumstances both Eustachian tubes may be catheterized through the unoccluded nostril. To reach the tube of the op- 346 DISEASES OF THE NOSE, THROAT, AND EAR posite side it will be necessary to bend the beak of the catheter at a somewhat longer curve than that of the instrument shown in Fig. 150. Ecchondroses or exostoses of the septum frequently interfere with the easy passage of the catheter through the inferior meatus of the nose. Under such circumstances the beak of the catheter can sometimes be passed over them and made to rest upon the floor of the nose or the soft palate behind. In passing the catheter through the nose the instrument Fig. 151.-Auscultation of the ear. should be held very lightly between the thumb and finger, and a tendency to rotate on its long axis should not be resisted, because by allowing the instrument to rotate its beak will sometimes glide around an obstruction and finally find its way into the pharynx. Another obstacle to catheterization of the Eustachian tubes results from spasmodic contraction of the muscles of the palate and pharynx, which tightly grasp the beak of the instrument and interfere with its proper manipulation. Gentleness and patience on the part of the surgeon will generally overcome this PATHOLOGIC CONDITIONS OF NOSE AND PHARYNX 347 difficulty. The patient should be requested to inhale deeply through his nose, to "swallow," or say "One," and thus pro- duce a temporary relaxation of the parts, which, if repeated from time to time, will enable the surgeon to guide the beak of the catheter into the mouth of the Eustachian tube. When the beak of the catheter is felt to be within the mouth of the Eustachian tube it should be held in position with the thumb and forefinger of the left hand and steadied by two fingers resting upon the patient's face (Fig. 151). The nozzle of the air-bag is then fitted loosely into the proximal end of the catheter and compressed with the right hand. If the auscul- tation-tube be employed at the same time, air will be heard to enter the patient's middle ear with a sound somewhat similar to that produced by inflating the middle ear by Valsalva's or Politzer's method. However, when the catheter is employed the sound seems as if produced nearer the surgeon's ear. The inflation of the middle ear by means of the Eustachian catheter is not altogether devoid of risk. Deaths have been reported. The fatal results in these instances may have resulted from injection of air through a rent in the mucous membrane made by the beak of the catheter, which subse- quently found its way beneath the mucous membrane to a position where the emphysema caused sufficient obstruction to respiration to occasion suffocation. The writer saw two cases where young and inexperienced operators had injected a sufficient amount of the air contained in a Politzer bag through a Eustachian catheter into the cellu- lar tissue to cause decided swelling of the tissues of the neck. In these two cases the patients simply suffered a certain amount of discomfort for a few hours, the air in the tissues being finally absorbed. Solutions may be sprayed through the catheter by means of an ordinary atomizer by inserting the nozzle of the atomizer into the catheter. Either the compressed-air apparatus or the hand-bulb may be used to produce the spray. Under ordinary circumstances the spray probably does not penetrate the tube 348 DISEASES OF THE NOSE, THROAT, AND EAR further than the isthmus, except the patient be told to swallow, when the spray may be heard through the auscultation-tube to enter the tympanum, sounding not unlike drops of rain falling on a tin roof. When compressed air is used to produce the spray it should be employed gently and with due caution. The automatic cut-off should be manipulated in such a manner as to throw the spray gently and by successive puffs into the Eustachian tube orifices. The drip of the solution that con- denses in the catheter should, at the completion of the treat- ment, be blown into the Eustachian tube by means of Politzer's bag. Instead of employing an atomizer, fluid may be inserted within the catheter by an ordinary glass medicine-dropper and thrown into the tube with Politzer's bag, or fluid may be syringed through the catheter into the Eustachian tube, and when the drum-head is perforated, through the Eustachian tube and tympanum into the external auditory canal. When the drum-head is intact, fluid enters a narrow Eusta- chian tube beyond the isthmus only with great difficulty, having to compress before it the air contained in the middle ear. As soon as the pressure is relaxed the spring or rebound of the compressed air generally throws into the pharynx fluid con- tained in the tube. However, during the act of swallowing fluid may be made to penetrate into the cavity of the tym- panum through the Eustachian tube even when the drum-head is intact, the muscular action in opening and shutting the tube during swallowing doubtless playing an important role under such circumstances. In this manner sea-water or fresh water introduced into the pharynx while bathing sometimes reaches the tympanum and almost invariably produces an acute otitis media. The writer has observed the same thing occur during the use of the Birmingham douche or even from sniffing normal salt solution into the nose from the hollow of the hand. The introduction of watery solutions, even of the blandest character, is not devoid of risk unless the drum-head is lacking or contains a large perforation. Bland oily fluids, on the other PATHOLOGIC CONDITIONS OF NOSE AND PHARYNX 349 hand, can be sprayed or syringed into the middle ear with impunity. When the watery fluid is used to wash out the Eustachian tube the operator should be careful to inflate the middle ear several times by means of Politzer's method in order to remove any excess of fluid that might otherwise remain. Solutions of one or two drops of argyrol, io to 50 per cent., nitrate of silver, | to 1 per cent., potassium iodid, 1 per cent, (in syphilis), may safely be introduced into the mouth of the Eustachian tube. An Allen's probe (Fig. 26), sufficiently long to extend | inch beyond the catheter mouth, may be used as an applicator by wrapping a few fibers of cotton about its tip and dipping the end of the probe into the solution to be used. After the beak of the catheter is in position the cotton-tipped probe is passed through it and an application of the remedy made to the first | inch of the Eustachian tube, or the end of a cotton-tipped Allen's probe, after being dipped into any appropriate solution, may be passed like a catheter through the nose into the naso- pharynx and the cotton-tipped end inserted into the mouth of the Eustachian tube. Eustachian bougies are occasionally used for the dilation of strictures of the Eustachian tube and other purposes. They are filiform in character and a number of sizes are obtainable, made of whalebone, hard rubber, celluloid, or gold, for electro- lysis of stricture. They are inserted into the Eustachian tube through a catheter. Great gentleness should be used in passing a Eustachian bougie for the first time through an inflamed tube, for it is easy to penetrate tissue with so small an instrument and make a false passage. The length of the catheter employed should be marked upon the bougie and also the length of the Eustachian tube, which is about i| inches; and this last mark cannot be passed without danger of injury to the tympanic contents. Not much force is necessary to pass a Eustachian bougie through a normal tube. When a stricture is encountered, 350 DISEASES OF THE NOSE, THROAT, AND EAR gentle pressure will usually finally overcome the obstruction, after which the bougie passes readily onward. The most fre- quent position of stricture is at the isthmus. Before attempting to pass the bougie a few drops of liquid albolene should be inserted in the catheter and blown into the Eustachian tube by means of Politzer's bag. If a stricture is passed, a bougie should be allowed to remain in position for five or ten minutes. After the bougie is withdrawn the middle ear should be gently and cautiously inflated. If there be reason to suppose that during the passage of the bougie the mucous mem- brane has been torn, it will be safer to dispense with inflation, lest air penetrate the cellular tissue. Electrolysis of Eustachian strictures has been done by means of an insulated Eustachian catheter and gold bougies. The amount of current necessary to overcome an obstruction and promote absorption of a stricture is 3 to 5 milliamperes, which should be turned on as soon as an obstruction is felt and con- tinued for not longer than three to five minutes. The negative pole of the battery is attached to the bougie, the positive held in the patient's hand or applied to the nape of his neck. There is little pain produced by the procedure, which may be repeated at intervals of a week. Inflation should not be practised immediately after the use of the electric bougie, but the patient may return the next day to have his middle ear inflated. DISEASES OF THE EXTERNAL EAR Congenital Defects.-The auricle may be wanting entirely or there may be a plurality of auricles (Fig. 152). The auricle may be abnormal as regards position or shape or it may only be partially developed. Malformations of the auricle are generally associated with defects or absence of the external auditory canal (Fig. 153), and sometimes imperfect development of the deeper portions of the auditory apparatus. A congenital fistula is sometimes seen about the external ear and may com- municate with the tympanic cavity (Fig. 154). Excessive DISEASES OF THE EXTERNAL EAR 351 development or lack of development of the external ear is due to excessive or imperfect development in the closure of the first branchial cleft during embryonic life. Various operations Fig. 152.-Supernumerary auricle in the neck (Lancet, 1888) have been devised to correct deformities of the auricle and open a way down to the tympanum in cases of stenosis of the external auditory canal. Plastic operations in this locality do well Fig. 153. - Congenital deformity of the auricle (Sexton). Fig. 154.-Convoluted auricle with congenital fis- tula (Sexton). as regards the healing process. Operations for the correction of atresia or stenosis of the external auditory canal hitherto have not been successful. 352 DISEASES OF THE NOSE, THROAT, AND EAR Othematoma or perichondritis of the auricle (Fig. 155) is generally the result of direct violence-self-inflicted in the insane, among whom the disease is not uncommon. This affection is characterized by an effusion beneath the perichon- drium of the auricle, causing swelling, tension, and pain in the part. The effusion may finally escape through an external opening which it has made for itself, remain as a swelling for an indefinite time, or slowly be absorbed. Even when reabsorp- tion of the effusion does occur, considerable deformity of the auricle may result (Fig. 156). Fig. 155.-Mumied-sized othe- matoma of the auricle (Sexton). Fig. 156.-Deformity of the auri- cle due to othematoma (Sexton). Treatment.--In the insane, hematoma of the auricle is best let alone, unless the local inflammation is sufficiently great to indicate that infection has occurred and that the effusion has become purulent. If necessary inflammation should be com- bated by the application of ichthyol ointment (20 per cent.) in lanolin (adeps lanae hydrosus), and progressive effusion by painting the affected parts with contractile collodion and the use of a pressure bandage. Absorbent cotton is placed between the auricle and the head and a pad of cotton over the auricle, and pressure maintained by means of a roller bandage over the DISEASES OF THE EXTERNAL EAR 353 auricle and around the head. The bandage should not be applied with sufficient firmness to cause pain or great discom- fort. If, notwithstanding these measures, the collection of fluid beneath the perichondrium increases, the parts should be aspirated with antiseptic precautions-a measure that will probably need repetition from time to time. In cases where the inflammation is great and the effusion beneath the perichon- drium is evidently purulent, it is best to lay the parts freely open, wash out the pus-cavity with sublimate solution, and pack with iodoform gauze. The incision should be sufficiently free to permit of easy dressing and the ready removal of sloughing cartilage as soon as separated from the living tissue. Fortunately the number of cases where the injury to the auricle is sufficiently severe to cause sloughing of even a small portion of the cartilage are comparatively few. Chronic perichondritis is a chronic inflammation of the car- tilage of the auricle observed in boxers and others whose ears are constantly subjected to irritation or slight traumatism. Treatment consists in gentle massage and applications of 20 per cent, ichthyol ointment at bedtime, with the avoidance of the cause of the irritation. Incised and punctured wounds, after thorough cleansing, should be sutured in such a manner as to leave as little scar as possible upon the lateral surface of the auricle. In contused and lacerated wounds perichondritis almost invariably occurs, and it is well to anticipate such an attack by the application of a wet bichlorid dressing for twelve to twenty-four hours. An attempt should be made to save as much tissue as possible and no part which possibly may have sufficient vitality to live should be removed. As a primary measure but few sutures should be used, as after the circulation has been thoroughly established it is ordinarily a simple matter to secure more perfect coaptation of the parts and prevent deformity. The sutures should not be passed through the cartilage unless abso- lutely necessary, although no great harm usually results from a suture through the cartilage of the auricle. 354 DISEASES OF THE NOSE, THROAT, AND EAR Fracture of the base of the skull involving the temporal bone may extend into the auditory canal in some cases without rup- ture of the membrana tympani. Hemorrhage from the ear may be somewhat profuse or scanty. In addition to the gen- eral treatment the ear should be thoroughly cleansed of clots by gentle syringing with a warm bichlorid solution (i: 5000), dried, and covered with powdered boric acid, except where oozing persists, when the auditory canal should be very lightly packed with sterile iodoform gauze. The ear should be gently cleansed once a day with the bichlorid solution and packed with gauze as long as oozing persists; after which the parts are best kept as dry as possible by cleansing when necessary with bichlorid solution, thoroughly drying the parts, and insufflating powdered boric acid. Boric acid in sufficient quantity to cover the wound is apparently sufficient to prevent infection. Packing the canal maintains a warm and moist condition of the wound that should be avoided. Cleft lobule, which is generally the result of the tearing out of an earring, may be- remedied by the following opera- tion : The sides of the cleft are freshened in the same man- ner as for a hare-lip operation; but, to avoid as far as possible the formation of a conspicuous scar, the sutures should be in- troduced and tied on the inner side of the lobule, and should involve only the deeper layers of the skin of its outer surface. Keloid of the auricle originating in the scar resulting from piercing the ear for earrings is not uncommon, especially in the negro. The growth consists of a hard nodule of fibrous tissue, generally tender on pressure. If large, it shoud be removed by the knife. There is a tendency for the growth to recur. En- couraging results have been reported from the application of the x-ray in cases where the growth has recurred after removal by the knife. The cutaneous diseases which sometimes attack the auricle are hyperemia, frost-bite, burns, eczema, dermatitis, comedo, cyst, erysipelas, syphiloderma, herpes, lupus, and impetigo contagiosa. DISEASES OF THE EXTERNAL EAR 355 Hyperemia may be either active or passive, transient or chronic in character. There is an increase in the blood-supply of the auricle and generally of the canal, so that the skin ap- pears redder than normal and feels hot to the patient. Mild cases are due to some transient vasomotor disturbance that usually soon passes away without treatment. In some indi- viduals a single comparatively small dose of quinin, salicylic acid, or of chlorid of calcium will produce hyperemia of the auricle and canal that may persist for some time. Active hyperemia of the auricle may result from exposure to cold, sunburn, or other irritants. Passive hyperemia of the auricle and canal are sometimes present as the result of gout, valvular disease of the heart, or any organic disease capable of producing localized blood stasis. Treatment.-The best local application is probably liquor plumbi subacetatis, which may be painted on the parts once or twice a day. Nervous cases will need building up; the gouty, a correction of the constitutional dyscrasia. Dermatitis is an inflammation of the skin generally resulting from some injury, such as the bite of an insect, a blow, fall, stab, wound, etc. The symptoms vary from slight inflammation of the skin at the point of injury to localized gangrene. Treatment.-This varies with the severity of the inflamma- tion and the character of the infection. Mild cases do well by simply painting with liquor plumbi subacetatis. The severer cases require a wet dressing of bichlorid of mercury, as in in- fected wounds of other parts of the body. The dermatitis following the sting of insects is treated by a wet dressing of 20 per cent, bicarbonate of sodium. Frost-bite.-In cold climates frost-bite of the auricle is by no means uncommon. At first the auricle is cold and numb and sometimes stiff, as if actually frozen solid. Later on the symptoms are those of traumatism, involving only the skin or the skin and deeper structures. The skin is hot and swollen, frequently excoriated or covered by vesicles. In the severer 356 DISEASES OF THE NOSE, THROAT, AND EAR cases the symptoms are those of perichondritis, followed some- times by cartilaginous necrosis and the formation of sinuses upon either surface of the auricle. Treatment.-When the auricle is frozen its temperature should be restored gradually by gentle friction with snow or pounded ice, and afterward by gentle manipulation with the fingers. If only the skin is involved by the subsequent in- flammation satisfactory results will follow the application of a io per cent, ichthyol ointment, which should be applied suffi- ciently often to keep the parts constantly covered and pro- tected. In some cases pain and soreness are greatly relieved by wrapping the auricle in absorbent cotton after using the oint- ment and applying gentle pressure by means of a bandage. When perichondritis follows frost-bite of the auricle it should be treated in the manner already described. When sinuses have formed, they should be laid open, the necrosed tissues re- moved, and the wounds allowed to heal by granulation. If care is taken to keep the parts properly supported but little deformity sometimes results. Cystic tumors are not uncommon and are best dissected out. When this is inadvisable, the cyst should be freely laid open, thoroughly curetted, and its interior painted with tincture of iodin. The wound is then closed with sutures and a wet bichlorid dressing applied. Bums.-The auricle is liable to burns, sometimes severe, and involving not only the surrounding neck and scalp but also the auditory canal. A common cause of slight burn of the auricle sufficient to raise a blister is hot applications for the relief of the pain of otitis media. Treatment.-Pain is best relieved by the local use of cold, applied either in the form of an ice-bag or napkins wrung out of ice-water. The application of cold should be continued as long as it affords relief. Charred and dead tissue, if the burn is a severe one, should be at once removed, and the parts cleansed from soot and dirt by means of copious washings with a solution of bicarbonate of DISEASES OF THE EXTERNAL EAR 357 sodium. The parts are then dusted with orthoform or smeared with a 3 per cent, carbolized petroleum, a bandage applied, and over this an ice-bag is placed as long as the cold seems necessary for the relief of pain. Excessive pain if not quickly relieved by these measures will require a hypodermic of morphin. When the skin is unbroken the best dressing is the so-called carron oil (equal parts of linseed oil and lime-water). This is smeared thickly on patent lint and applied to parts after they have been cleansed with bicarbonate of sodium solution. Herpes of the auricle is similar to the disease in other locali- ties. It is characterized by vesicles filled with a clear serum, appearing singly or in groups, upon the helix or about the lobule. The surrounding skin is reddened, slightly swollen, and tender to the touch. There may be slight fever, pain, and itching of the auricle. The affection is due to some nervous disturbance. The vesicles ordinarily dry up and disappear by the end of ten days or two weeks. Treatment.-The milder cases are best treated by gentle pur- gation with citrate of magnesia or one of the other salines. The vesicles should be painted three or four times a day with camphorated tincture of opium (paregoric). This application seems to allay the slight itching and burning better than most others and hastens absorption. Should the contents of the vesicles become purulent, the vesicles should be opened and the parts washed with bichlorid solution and dusted with pow- dered calomel. Impetigo contagiosa is an acute contagious disease of the skin sometimes encountered upon the skin of the auricle or nose in dispensary practice. It begins as small discrete or confluent vesicles, which rupture and leave a granular surface resembling closely a vaccination sore. It is contagious. Recovery usually occurs within a week under antiseptic treatment. Treatment consists in keeping the parts clean by washing with bichlorid solution and applying either powdered calomel or an ointment of ammoniated mercury. Lupus vulgaris is a chronic tuberculosis of the skin of the 358 DISEASES OF THE NOSE, THROAT, AND EAR auricle, either primary or extending to the auricle from the skin of the face. The disease begins as a tubercle deep in the skin. The dull reddish tubercles are sometimes years in developing, but finally break down into a characteristic ulceration which may heal at one extremity while it is spreading in another direction. The disease is exceedingly chronic and years may go before a large portion of the auricle is involved. After heal- ing has occurred the auricle is shriveled, shrunken, and deformed. The diagnosis is usually made by the appearance of the ulcer and the history of extreme chronicity. The disease might be mistaken for either syphilis or epithelioma, but each is much more rapid in its course. Treatment.-The internal medication consists in the admin- istration of cod-liver oil and arsenic. The local treatment consists in a thorough curetting of the ulceration and the appli- cation of the solid stick of nitrate of silver. This should be followed by applications of the £-ray. Syphilis.-Primary syphilis of the auricle is naturally rare, but the auricle may become inoculated by a bite or other cause. Chancre of the auricle differs in nowise from the primary lesion elsewhere upon the skin. It is an ulcer with indurated edges and a hard base, generally conforming to the papular type. The lymphatics of the neck are swollen. Secondary syphilis of the auricle is generally part of a syphi- loderm involving more or less of the whole body. Tertiary syphilis of the auricle consists of a gumma either before or during the stage of ulceration. The diagnosis of the primary lesion is sometimes difficult unless there is a history of a bite or injury by a syphilitic individual. The diagnosis in the secondary stage is usually easy. In the tertiary stage, however, an ulcerating gumma may be mistaken for either lupus or epithelioma. Treatment.-The constitutional treatment differs in nowise from that of syphilis of the nose, pharynx, or larynx already described. DISEASES OF THE EXTERNAL EAR 359 Congenital syphilis is usually of the tertiary variety. Its treatment differs in no respect from the acquired disease. The writer remembers only one case observed by him, that of an in- fant about eight months old, with an ulcerating gumma of the meatus. The external orifice of the meatus was nearly oc- cluded by exuberant granulations, which were snared away and the parts kept clean and dusted with calomel powder. The internal treatment consisted of gray powder and inunc- tions of mercury. The infant made a good recovery. Erysipelas is the result of infection of the skin with the strep- tococcus erysipelatosa of Fehleisen. It is presumed to only in- vade the skin through some traumatism, possibly so minute as to be overlooked. The writer saw in consultation two cases that had their origin in a blister produced by painting the mastoid process with cantharidal collodion. In both these cases, occurring in old men, the erysipelas extended to the scalp; in one with a fatal result. Erysipelas of the auricle may extend along the canal and involve the drum-head. The symptoms are those of erysipelas in other localities. The disease is usually ushered in by a chill and high tempera- ture. There is headache and anorexia. The infected area is red and swollen and the swelling and redness somewhat rapidly spread until sometimes the entire auricle is involved and the disease has attacked adjacent skin areas. Vesicles filled with serum may or may not appear. Treatment- The patient, if in a hospital, should be isolated from other surgical cases. It is well to begin treatment with a calomel purge (f gr. every hour until i| gr. have been taken), followed by a bottle of the solution of citrate of magnesia. As soon as the bowels have acted freely the patient should take 20 drops of the tincture of the chlorid of iron every two or three hours and gr. of strychnin every four hours. It is said that some cases can be aborted by painting the infected and adjacent skin area with carbolic acid, which is allowed to remain until it has blanched the skin surface. The excess of acid is then washed off with alcohol. Most of the writer's 360 DISEASES OF THE NOSE, THROAT, AND EAR cases have been treated locally by application of 20 per cent, ichthyol in lanolin, which was smeared thickly on patent lint and applied to the parts. The treatment is effective, but some- what dirty. Those cases of facial erysipelas seen in the Philadelphia Hospital during his terms of service there were treated locally by applications of patent lint kept moist with a 10 per cent, solution of protargol. Apparently one treat- ment was about as effective in controlling the local symptoms as the other. Phlegmonous erysipelas is a severe form of erysipelas in- volving the deeper structures beneath the skin, with the forma- tion of abscesses. It is generally the result of mixed infection, the streptococcus erysipelatosa and the streptococcus or sta- phylococcus pyogenes being found in the discharges. The symptoms are those of severe erysipelas--high fever, redness, pain, and great swelling of the auricle, with formation of pus and exfoliation of cartilage. Treatment.-The auricle should be covered with a dressing kept constantly wet with bichlorid solution (1: 2000). As soon as the presence of pus is suspected the parts should be freely incised down to the cartilage. The wound should be syringed daily with a bichlorid solution and, if necessary, packed with gauze in such a manner as to secure perfect drainage. Gangrene is, in modern times, an extremely rare disease, but is said to occur occasionally either in the moist or dry form. Treatment.-This is similar to that of phlegmonous erysipe- las. Iron and strychnin should be given internally. The parts should be kept covered with a wet bichlorid dressing and every effort made to secure asepsis. The necrotic tissue should be removed as soon as possible. Localized pain can be controlled by dusting with iodoform and, when this is in- effective, with orthoform. The disease is very contagious, at least to other surgical cases. Therefore the patient should be carefully quarantined and all dressings, towels, etc., used about the case destroyed. DISEASES OF THE EXTERNAL EAR 361 Eczema is by far the commonest of the skin diseases affect- ing the auricle. It may also involve the auditory canal and even the dermoid layer of the membrana tympani. Intertrigo resulting fro the invasion by the disease of the fissure formed by the junction of the auricle with the mastoid region is of frequent occurrence in infants and young children. Treatment.-In adults the disease is sometimes the result of the rheumatic or gouty diathesis, and, in addition to local treatment, such cases require the administration of alkalis, with iodid of potassium, salicylate of sodium, or arsenic. In children the disease is frequently associated with struma, and for such cases cod-liver oil or syrup of the iodid of iron should be prescribed. Eczema intertrigo is best treated by the fre- quent application of powders, and oxid of zinc or subnitrate of bismuth may be prescribed for this purpose. The commonest cause of eczema of the auricle in children is an irritating discharge from the middle ear. In the neglected infants of the poor the discharges resulting from purulent inflammation of the tympanum are frequently smeared by the fingers of the child over the entire auricle and over the skin in front of and behind the ear. Under such circumstances the auricle and surrounding skin become covered by eczematous scabs and crusts. These the surgeon should carefully remove by means of pledgets of cotton saturated with hydrogen peroxid, and rub well into the affected parts an ointment con- sisting of 6 or 8 gr. of the yellow oxid of mercury to i ounce of petrolatum. A single thorough application of this remedy is sometimes sufficient to bring about great improvement, even in cases in which the disease has existed for several months. Perfect cleanliness in all cases should be enjoined, and if fre- quent cleansing of the auditory canal with absorbent cotton, followed by insufflations of powdered boric acid, is not suffi- cient to keep the concha dry and free from the discharge, the skin of this part of the ear should be protected by some bland ointment. Benzoated zinc ointment, if fresh and properly made, answers very well for this purpose. 362 DISEASES OF THE NOSE, THROAT, AND EAR The new growths that occur on the auricle are sebaceous cyst, fibroid tumor, epithelioma, nevus, sarcoma, and cornu cutaneum. The treatment is the same as if the new growths occurred elsewhere. Nevi in suitable cases should be treated by electrol- ysis. The other growths ordinarily require excision. DISEASES OF THE EXTERNAL AUDITORY CANAL The more common affections of the external auditory canal are acute circumscribed inflammation or furunculosis, acute and chronic diffuse inflammation, diphtheritic inflammation, hyperostosis, exostosis, and foreign bodies. Furuncle or Acute Circumscribed Inflammation.-Recur- rent attacks of furunculosis of the auditory canal seem, in many instances, to be the result of irritation from carious teeth or from disease of the interior of the nose and throat. The affection is commonest in gouty or anemic and debilitated individuals and in women suffering from menstrual disorders. Pathology.-In most instances the starting-point of the dis- ease is a sebaceous gland or a ceruminous follicle, which has become inoculated with the staphylococcus pyogenes aureus or other pus-forming bacteria by scratching the ear with a dirty finger-nail, hairpin, match-stick, etc. Metastatic abscess in the canal is said to sometimes occur in gonorrhea. The in- flammation usually soon becomes a circumscribed perichon- dritis or periostitis of the auditory canal. The pathology of acute circumscribed inflammation of the external auditory canal is similar to that of boils and felons occurring elsewhere on the body. Symptoms.-There is at first an itching within the canal, a portion of which is found tender to the touch, and soon becomes painful. The pain and tenderness increase, until in some instances the patient's sufferings become almost unendurable. In severe cases the pain, which at first was confined to the ear, extends to the whole side of the head, is throbbing in character, DISEASES OF THE EXTERNAL EAR 363 and is increased by movements of the jaw in talking, eating, etc. There is some elevation of temperature in the severest cases. Deafness is not a marked symptom until the swelling is large enough to close the canal at the part involved, but tinnitus is present in the majority of cases. The furuncle will rupture spontaneously in from two to eight days, according as the inflammation is superficial or deep seated. The dis- charge is purulent, sometimes quite profuse, and its appearance is speedily followed by a subsidence of acute pain; the parts, however, remain sore for several days. A "core" or small slough of the skin, as in boils elsewhere, usually exfoliates before the parts heal. Treatment.-Speedy relief generally follows a free incision Fig. 157.-Method of wrapping cotton about the end of an Allen probe to form a brush for cleansing the canal, applying pigments, etc. through the swollen parts down to the cartilage or bone, even though no pus be found. The incision should be followed by syringing the canal with hot boric acid solution, the insertion into the canal of a cone of absorbent cotton covered with a io per cent, ointment of cocain in lanolin, and the application of heat. In cases where incision is not advisable, a cone of cotton should be well covered with an ointment of the yellow oxid of mercury, 6 gr. to an ounce of vaselin, and so placed within the canal that it will exert pressure upon the swollen parts. For a few moments this procedure increases the pain somewhat, but it is followed by a feeling of decided relief and comfort. The ointment is rubbed into the skin of the canal by each movement of the jaw in talking and eating, and if the treat- 364 DISEASES OF THE NOSE, THROAT, AND EAR ment is applied early enough many cases of furunculosis of the auditory canal may be aborted before suppuration has occurred. Cotton cones are readily made by selecting a piece of absorbent cotton about 2 inches long and about f inch wide. The two ends of the piece of cotton are then frayed out until the center of the cotton is thicker than the edges. The cotton is then folded through its thick central portion, so that the thin edges are brought together and a wedge is thus formed, one edge being very thick and the other thin. This wedge is now wrapped somewhat firmly about the end of an Allen ear probe (Fig. 158), the thick edge of the cotton wedge toward the handle of the instrument, in such a manner that the thin edge of the Fig. 158.-Method of wrapping cotton about the end of an Allen probe so as to form a cone for applying pressure within the auditory canal. A piece of absorb- ent cotton is frayed out to thin edges, folded through the center (dotted line a), and wrapped about the end of the probe. cotton wedge forms the pointed end of the cone. The cone thus made should be firmly enough wrapped about the probe to be smooth and taper evenly from apex to base. When made it is coated thickly with the appropriate ointment and inserted gently into the canal until its wedge-like pressure begins to cause pain. The probe is then dislodged from the cone by turning it in the opposite direction to that in which the cotton was wrapped about it and steadying the cone with a touch of the left forefinger so that the cone is not withdrawn from the canal with the probe. If after a few moments the pressure of the cone instead of affording relief causes increased pain, the patient can withdraw it slightly and after an interval again push it more deeply into the canal. Some relief from pain follows the application of a io per cent. DISEASES OF THE EXTERNAL EAR 365 ointment of cocain in lanolin or a i per cent, ointment of atro- pin. Heat, however, generally gives speedy relief from pain. It may be applied by gently syringing the canal with hot water, or by resting the head upon a hot-water bag or a bag of hot salt or of hops. In severe cases it is advisable to secure a free evacuation of the bowels by means of small, frequently repeated doses of calomel and bicarbonate of sodium; i-drop doses (U. S. P., 1890) of tincture of aconite-root, repeated every hour, will control to a certain extent fever and pain. In all case the cause of the attack should carefully be sought and measures adopted to prevent a recurrence. To prevent in- oculation of other parts of the canal and producing a so-called "crop" of boils, the canal should be carefully cleansed either by syringing gently each day with a warm 1 :5000 bichlorid solution or by simply wiping out the pus with absorbent cotton and afterward sterilizing the skin of the canal by painting it with a 12 per cent, solution of silver nitrate. Otitis Externa Diffusa Acuta.-Diffuse inflammation of the auditory canal varies in character from a simple erythema of the skin of the auditory canal to severe periostitis. The dis- ease usually attacks the osseous portion of the canal, but it may extend to the auricle, and, by periosteal continuity, to the periauricular and mastoid regions, causing abscess and necrosis. Etiology.-'The disease usually occurs in persons whose gen- eral health is impaired. It is sometimes consecutive to an attack of otitis media acuta or it may be caused by an irritating discharge from the middle ear. The affection, which usually begins in the skin or cellular tissue, may extend to the peri- osteum and bone. The symptoms are similar to those of furuncle of the auditory canal, except that the pain is usually more intense and appears at an earlier stage of the disease, while deafness and tinnitus are more marked and long continued. On inspection the tissues of the auditory canal appear red and swollen. The swelling is usually greatest in the bony portion of the canal, where it may be so great as to completely obliterate the canal and prevent a 366 DISEASES OF THE NOSE, THROAT, AND EAR view of the drum-head from being obtained. Generally the skin is excoriated at points where the inflammation is great- est, and usually there is desquamation and a slight watery discharge. Treatment.-Incision of the swollen tissues is rarely necessary unless an abscess has formed. Pain can generally be alleviated very much, if the case is seen early, by the application of a large leech to the skin in front of the tip of the mastoid, as closely as possible beneath the auditory canal. A leech also may be applied in front of the tragus and one on the mastoid, as close to the canal as possible. In many cases it will be necessary to prescribe morphin to completely control the pain and secure sleep; but heat, applied in the manner already described, will be all that is necessary in the majority of instances. The canal should be cleansed and carefully dried with absorbent cotton and the parts painted with a 12 per cent, solution of nitrate of silver and dusted with powdered calomel. This should be done every day as long as the symptoms are acute, and afterward, as the disease subsides, at longer intervals. In using an insoluble powder like calomel within the canal care should be exercised not to employ a quantity sufficient to form a hard crust and cause pain. Otitis Externa Haemorrhagica.-Hemorrhagic blebs some- times occur in the canal from traumatism or as a complication of influenza or otitis media. The blebs are bluish, easily rup- tured, and contain bloody serum. They should be broken with a cotton-tipped Allen applicator, touched with a 12 per cent, solution of silver nitrate, and then dusted with calomel or powdered boric acid. Otitis externa diffusa chronica occurs in individuals whose health is impaired, or it may be the result of the gouty or rheu- matic diathesis, or the irritation caused by carious teeth, or dis- ease of the nose and throat. The growth of aspergillus within the inflamed canal may be a complication or a cause of disease. Symptoms.-Patients complain of itching and a sense of heat within the canal. Pain is usually absent, except during DISEASES OF THE EXTERNAL EAR 367 acute exacerbations. Upon inspection the skin of the auditory canal is found to be red and swollen, especially in the deeper portions. The inflammation may be of the eczematous or desquamative type and accompanied by a watery discharge or seborrhea. Treatment.-The cause of the affection should be carefully sought. Patients of the strumous diathesis or in feeble health will require cod-liver oil and tonics, and appropriate remedies should be prescribed for those in whom the disease seems to be the result of the rheumatic or gouty diathesis. If carious teeth are present they should receive the attention of a skilful den- tist, and any disease of the nose or throat that may be present Fig. 159.-A, Aspergillus glaucus; B, Aspergillus niger; C, ripe fructiferous head of Aspergillus niger throwing off spores (Burnett). should be properly treated. The local treatment of chronic diffuse inflammation of the external auditory canal varies according to the stage and variety of the disease. When the disease is of the eczematous type, all scales and scabs should be removed with a pledget of absorbent cotton wrapped about a probe and dipped into a solution of hydrogen peroxid, and yel- low oxid of mercury ointment (Formula 108) well rubbed into the parts. When there is considerable secretion of watery fluid the canal should be dried thoroughly and brushed with a solution of silver nitrate (12 per cent.) and covered with pow- dered calomel. 368 DISEASES OF THE NOSE, THROAT, AND EAR Mycosis or otomycosis is an inflammation of the external auditory canal due to the presence of a fungus. Aspergillus glaucus (Fig. 159, a) and Aspergillus niger (Fig. 159, b, c) are the varieties most frequently met with. The presence of moulds in chronic inflammation of the external auditory canal may be the cause of the inflammation or only a complication of the disease. The symptoms are those of an acute or chronic inflammation of the canal, except that when there is a large mass of mould present filling the fundus of the canal the patient will be deaf from the accumulation. This is usually a pasty, whitish mate- rial interspersed with black spots looking not unlike a wad of wet newspaper. The microscope will detect the presence of either or both the Aspergillus glaucus or niger or some other species of aspergillus or mucor. Treatment.-When aspergillus is present, the canal should be cleansed thoroughly each day with hydrogen peroxid and an application made of a 12 per cent, solution of silver nitrate or of alcohol. It is essential that the canal should at all times be kept absolutely dry, because nothing more favors the growth of the aspergillus than moisture. Discharges should be absorbed by the application of powdered boric acid. Otitis Externa Diphtheritica.-Diphtheritic inflammation of the integument of the external auditory canal is an inflam- mation characterized by the presence of a pseudomembrane, which when removed leaves a bleeding surface. The pseudo- membrane should contain the Klebs-Loffler bacillus character- istic of true diphtheria, as other bacteria are capable of causing a pseudomembrane within the auditory canal and upon mucous surfaces. Etiology.-The disease occurs usually as a complication of diphtheria of the throat and middle ear. Primary diphtheria of the walls of the external auditory canal has been observed during epidemics of diphtheria. Symptoms.-In the primary form there are deafness and tin- nitus, with pain. The meatus is greatly swollen. The lym- DISEASES OF THE EXTERNAL EAR 369 phatics at the angle of the jaw are swollen and tender to the touch. There is usually systemic depression and slight ele- vation of temperature. Examination discloses the pseudo- membrane covering the swollen skin bathed in discharges, so that the canal is nearly occluded, or, if the disease has occurred in a case where the drum-head has been previously destroyed, only the mucous membrane of the tympanum may be occupied by the diphtheritic membrane. The secondary form of the disease sometimes causes destruc- tion of the membrana tympani and the tympanic contents. Occasionally, as in scarlet fever, necrosis of portions of the tem- poral bone occurs. Treatment.-The canal should be syringed with a warm bi- chlorid solution (1:1000). The pseudomembrane should then be removed with the forceps and hydrogen peroxid. After the parts have been cleansed of membrane they are dried with absorbent cotton and painted with a 12 per cent, solution of nitrate of silver and covered with a thick coating of boric acid. Pepsin, trypsin, caroid, and other substances will dissolve the pseudomembrane, but their use is not desirable in the ear because the pseudomembrane soon ceases to re-form when the parts are constantly covered by antiseptics. Otitis externa crouposa is an acute inflammation of the external auditory canal characterized by the presence of a pseu- domembrane which does not contain the characteristic bacilli of diphtheria. Diagnosis.-The membrane when removed commonly leaves a bleeding surface, as is the case with the pseudomembrane of diphtheria, because croupous membranes rarely if ever occur except upon a skin not already excoriated. The bacteria are those of a mixed infection, usually strepto- coccus and staphylococcus. The symptoms are practically those of diphtheria of the ex- ternal auditory canal, except that the cervical glands are rarely as much swollen and inflamed. There is earache, 370 DISEASES OF THE NOSE, THROAT, AND EAR tinnitus, and a greatly swollen meatus, with purulent dis- charge and, generally, slight fever. The treatment is the same as in diphtheritic otitis. Extostosis and Hyperostosis (Osteomata).-Exostoses of the meatus are usually single and pedunculated. Hyperostoses are situated at the inner end of the meatus close to the membrane, are sessile, and generally multiple (Fig. 160). Both exostoses and hyperostoses are whitish prominences, firm and hard when touched with a probe. Etiology.-Hyperostoses in most instances are probably congenital, and in all cases their presence and growth are painless, while an exostosis is always preceded by inflammation. A sub- periosteal abscess forms over the mastoid, the pus finding its way into the meatus at the junction of the cartilaginous and bony portions of the canal. The mouth of the sinus in this position becomes occupied by exuberant granula- tions from the bone, which become converted into bone. Symptoms.-Hearing is not impaired unless the bony growth or growths are large enough to entirely block the lumen of the meatus. The smallest opening is sufficient to transmit sound- waves. If, however, such a small opening is occluded by a drop of fluid, or by a few scales of epithelium, or by a small mass of cerumen, the hearing at once is greatly impaired. When purulent disease of the middle ear is present the presence of hyperostoses will greatly interfere with drainage and render the disease difficult to cure. Treatment.-If an exostosis is large and attached by a rather small pedicle to the auditory canal, especially if the growth be slightly movable, it can readily be detached by means of a small chisel and extracted with a pair of forceps. Exostoses of this character should always be removed. Occasionally sessile exostoses are encountered that extend the whole length of the bony canal and encroach upon the position Fig, 160.-Exostoses and hyper- ostoses (Spalding). DISEASES OF THE EXTERNAL EAR 371 of the drum-head. Under such circumstances it is best to secure additional room for the necessary chiseling by detaching the auricle and cartilaginous canal and pushing it forward out of the way in the same manner as in the radical mastoid opera- tion. The bony canal should be enlarged by the removal of rather more bone than that comprising the exostosis, in order to provide for cicatricial contraction during the healing process. If the cartilaginous portion of the canal is contracted, it should be slit up and the parts adjusted in position in the same manner as after a radical mastoid operation. The more superficial parts of the exostosis are very readily removed by a suitable gouge or chisel; but when the neighborhood of the drum-head is reached it is well to employ a dental burr if the bone is found to lie closely in contact with the drum-head. Hyperostoses are best let alone, even in those cases in which they encroach upon the canal to such an extent as to decrease greatly its lumen. If from time to time the patient becomes deaf from an accumulation of cerumen between the hyper- ostoses, this should be picked carefully away by means of an appropriate instrument. The syringe should not be used unless absolutely necessary, for it is often difficult to remove fluid from behind the hyperostoses after syringing, and it may be the cause of an inflammation of the auditory canal and drum- head exceedingly difficult to control. Where the presence of hyperostoses seriously interferes with proper drainage in cases of purulent otitis an attempt should be made to effect a removal of one or more of the growths by means of a drill propelled by an electric motor. Foreign Bodies.-Animate and inanimate objects, impacted cerumen, and laminated epithelial plugs are found in the audi- tory canal. Animate objects that may enter the auditory canal are flies and other insects, the larvae of insects, and various moulds. The treatment when the auditory canal is involved by a growth of aspergillus, mucor, or other moulds has already been detailed (p. 368). Insects can generally be removed readily 372 DISEASES OF THE NOSE, THROAT, AND EAR by means of the syringe. The larvae of insects are not usually present unless there be suppuration of the middle ear, but cases have been reported of the presence of maggots within the auditory canal when the drum-head was intact and no suppura- tion existed. Larvae can be killed with chloroform vapor and then removed by means of the syringe. It is not permissible to drop chloroform into the auditory canal, as a blister may result. A part of a drop may be ab- sorbed by a small amount of cotton, which in turn is surrounded by sufficient cotton to make the plug fit snugly into the canal. Used in this manner the chloroform evaporates from the cotton into the canal, and the vapor produces a sensation of warmth and comfort. Generally the pain caused by the movements of the insects ceases within a few seconds after the use of the chloroform vapor, and the insect may then be removed by syringing or, if necessary, with the forceps. In the case of ants, wood-ticks, or other insects that sometimes attach themselves to the canal of the drum-head by their strong mandibles or jaws, the death of the insect is not always followed by a release of its hold upon the tissues. Under such circumstances the dead body of the insect can be removed by a pair of forceps. In the case of the wood-tick a portion of the tissue to which it has attached itself may be drawn out with the insect. This is a matter of no great consequence when the insect has attached itself to a portion of the canal; but irreparable mis- chief might be done by ill-considered efforts at removal when the insect has attached itself to the drum-head. It is said that the insect will unclasp its mandibles if touched with a drop of turpentine. In cases where, because of the nervousness of the patient or swelling of the canal, it is impossible at once to remove an insect that has been cholroformed, the canal should be filled with fluid vaselin or some other bland oil to prevent the resuscitation of the insect should the amount of chloroform vapor have proved insufficient to have caused its death. Inanimate Objects.-Shoe-buttons, pebbles, glass beads, the DISEASES OF THE EXTERNAL EAR 373 end of lead- and slate-pencils, and other objects are sometimes placed by children with n their ears in a spirit of mischief. It is not rare to find parts of an onion or pieces of cotton that were placed within the auditory canal by patients perhaps months or years before and forgotten. The writer removed from an old gentleman's ear three little wads of cotton which had been placed there several years before when he was treating himself for what he stated was "a boil in his ear." On one occasion, having demonstrated the removal of a foreign body from the ear of a dispensary patient before a ward class of ten or twelve senior students, the writer was requested by one of these students to examine his ear, as he thought he had got sand in it while bathing at Atlantic City the previous summer. There was removed not only a small amount of sand but also a cherry stone, black from age, which the student stated he dimly remembered having placed in his ear when a child. From the ear of another member of this same class was removed a small wad of cotton which the student stated must have been placed there the winter before. These stories illustrate how little annoyance foreign bodies in the ear sometimes cause. On the other hand, impacted cerumen and other foreign bodies are said to have been the cause of persistent cough, nausea, and even epilepsy. As some sensitive patients cough almost continually while their ear is being cleansed and more especially when the floor of the canal at the junction of the cartilaginous and bony portion is rubbed with a probe, while others become faint and nauseated under similar circumstances, it is readily understood how in a neurotic or hysteric individual the presence of a foreign body in the ear might be the cause of such unusual symptoms. Among the foreign bodies may be classed impacted cerumen and laminated epithelial plugs. Removal of Foreign Bodies.-Leaves of the onion, wads of cotton, and other soft objects are readily grasped by mouse- toothed forceps and extracted. Hard round objects, such as shoe-buttons and glass beads, should at first be attacked by 374 DISEASES OF THE NOSE, THROAT, AND EAR means of a syringe. A fine cannula should be placed in such a position that a stream of fluid can be thrown into the auditory canal past the object. If careful syringing in this manner fails to dislodge the foreign body, a delicate hook, made by bending the end of an Allen probe at a right angle (Fig. 161), should be introduced into the canal between its wall and the object, and an effort made to roll the object outward through the canal. Hard, irregularly shaped bodies that cannot be rolled out with a hook or grasped with the forceps will often tax the ingenuity of the surgeon to effect their removal. In such cases strong cement or glue may be smeared on the outer surface of the foreign body and then a small mass of cotton applied. After a day or two, when the cotton is firmly attached to the foreign body, the cotton can be grasped with forceps and the foreign body removed. Efforts at removal of foreign bodies should always be made Fig. 161.-Allen's probe bent to hook cerumen, etc. with extreme gentleness for fear of injuring the drum-head, and the surgeon should bear in mind that rather than incur the risk of doing so it is preferable to detach the auricle from the bony meatus by means of an incision posterior to the auricle, and turn the auricle and cartilaginous meatus forward upon the cheek. In children it is generally necessary to give an anesthetic to secure that perfect quiescence of the patient necessary for the delicate and careful manipulation of instruments. In difficult cases it is best not to prolong unsuccessful efforts to remove a foreign body, for often it will remain in the auditory canal for years without producing any serious symptoms. In cases where it has been impossible to remove the foreign body at the first sitting, time should be given for the inflammation to sub- side, and after all swelling of the auditory canal has disappeared, efforts for the extraction of the foreign body will finally prove DISEASES OF THE EXTERNAL EAR 375 successful. Seeds and other objects that have swollen by the absorption of water may be dehydrated and shrunken by the instillation of alcohol. Cases in which the uninitiated, by injudicious and unsuccess- ful efforts to remove a foreign body, have ruptured the drum- membrane and caused acute purulent inflammation of the middle ear, and in which so much swelling of the canal has arisen that nothing can be seen, should be treated by frequent syringings with warm water and by the use of a hot-water bag, if necessary to relieve pain, until the inflammatory symptoms have subsided and the foreign body can be seen. No attempt at its removal should be made until swelling has subsided and the speculum can be used without causing pain. Impacted Cerumen.-Subjective Symptoms.-There usually is a sense of fulness and itching, and the patient complains that he has suddenly become deaf in one ear without any previous symptoms of inflammation. The explanation of this fact is that so long as there is the smallest conceivable opening through a mass of cerumen it will be sufficient to transmit sound-waves and the hearing will not be greatly impaired. Sometimes a small opening through a mass of cerumen will close from time to time during damp weather and open again when the atmos- phere becomes dry. This phenomenon may be repeated many times, the patient being deaf only during damp weather. Even when impacted cerumen is present in both auditory canals the patient usually becomes deaf in one ear first. Under such circumstances the larger amount of inspissated cerumen may be removed from the ear in which the hearing is most nearly per- fect, sometimes after the patient has protested that "there is nothing the matter with that ear." Etiology.-Increased secretion of cerumen is usually the re- sult of disease of the middle ear or of catarrh of the nose and throat. It is rather unusual to find the hearing perfect after the removal of a mass of impacted cerumen. The introduction of irritants within the auditory canal increases the secretion of cerumen. 376 DISEASES OF THE NOSE, THROAT, AND EAR This is true of dusty employments, like coal-mining, stoking, or milling. Under such circumstances the mass of cerumen removed may consist partly of coal-dust or flour introduced into the canal by the dirty fingers of the workman while endeavoring to relieve the irritation of the canal by scratching it. Impac- tions result from ill-advised efforts to cleanse the canal by in- serting into it the screwed-up corner of a towel or the clumsy use of a match-stick or ear-spoon. When such articles are used dead epithelial scales and inspissated cerumen are thrust deep into the canal, which, if left to themselves, would have scaled off or exfoliated and dropped out of the canal. Treatment.-If the mass be soft, syringing with warm water will quickly remove it. Although inspissated cerumen is perhaps as readily soluble in water as any other bland fluid ex- cept hydrogen peroxid, a 5 per cent, solution of sodium bi- carbonate in glycerin and water is sometimes prescribed to be dropped into the ear several times a day to soften inspis- sated cerumen before efforts are made to extract the mass by syringing. However, it should be borne in mind that the hearing will be temporarily impaired as the result of dropping any fluid into the auditory canal when it contains a considerable quantity of cerumen, for reasons stated above. After the lapse of a few hours the wax may in rare instances have been increased in bulk sufficiently to cause pressure pain. When the surgeon is sufficiently expert with hook and syringe, it is never necessary to employ any fluid to soften the cerumen, the removal of the hardest and largest specimens being the work of only a few moments. When the impacted cerumen is very hard and firmly fixed within the auditory canal it is probably best not to attempt to remove it by syringing until the mass has been rendered mova- ble by manipulation with instruments. For this purpose the tip of an Allen steel probe, bent at a right angle (Fig. 161), should be introduced flatwise between the wall of the canal and the cerumen until it has penetrated a short distance, when the DISEASES OF THE EXTERNAL EAR 377 hook should be turned into the mass of cerumen and gentle traction exerted. Generally there will be detached a small portion of the impacted cerumen, which can easily be removed from the canal. Proceeding carefully in this manner it is sometimes possible to remove, even in those cases in which the wall of the canal is very sensitive, the entire mass of im- pacted cerumen without causing even the slightest pain or congestion of the drum-head, the procedure being vastly less Fig. 162.-Washing impacted cerumen from canal. Showing how to hold auricle to straighten canal and where to direct the stream of water. disagreeable to the patient than syringing. However, it is best in many instances to desist as soon as the mass of cerumen is felt to be movable, and resort to the syringe. The syringe used by dentists to cleanse carious cavities in teeth (Fig. 28, c with nozzle 8) is an admirable instrument for syringing cerumen from the ear. The stream of fluid should be thrown behind the impacted cerumen through the opening that has been made by an instrument (Fig. 162). One or two syringefuls of warm water will probably suffice to remove the greater portion of the 378 DISEASES OF THE NOSE, THROAT, AND EAR cerumen, after which the auditory canal should carefully be cleansed of any remaining flakes by a dossil of absorbent cot- ton wrapped about the end of an Allen probe and dipped into the solution of hydrogen peroxid. A metal ear-spout (Fig. 163) will be found convenient to receive the fluid from the auditory canal during the syringing. It should be borne in mind that syringing an ear is at best a disagreeable procedure, and that the injection of water either too cold or too hot or with too much force into the auditory canal is usuallv followed by syncope. Where the quantity of cerumen is so large that it is impossible for the first syringeful to reach the drum-head, it is justifiable to inject with considerable force, but as the tympanum is approached judicious gen- tleness should be employed. Especially where the drum-head is lacking, syringing the ear may be made absolutely intolerable by want of gen- tleness and judgment on the part of the operator. Keratosis Obturans or Epithelial Plug.-In masses of impacted cerumen there are more or less epithelial laminae. However, the typic laminated epithelial plug consists almost en- tirely of laminae of epithelium packed one about the other. The external end of such a mass is generally covered by inspissated cerumen which, of course, is easily removed by syringing when the laminae of closely packed epithelial scales are exposed to view, looking not unlike a plug of wet chamois skin. It is impos- sible to remove such an accumulation by syringing. It is necessary to effect its removal layer by layer by means of a hook, a curette, or by forceps. A laminated epithelial plug is composed of the horny layer of the cutis of the auditory canal, which accumulates, layer by layer, within the canal as the result of desquamative inflammation. After the removal of a laminated epithelial plug the membrana tympani will probably be found normal in appearance and the hearing be perfect. Fig. 163.- Metal ear-spout. DISEASES OF THE MIDDLE EAR 379 Usually this is not the case when the collection within the ear consists of a cholesteatomatous mass. DISEASES OF THE MIDDLE EAR THE MEMBRANA TYMPANI When inspecting those parts of the ear visible by otoscopy the attention of the observer should be particularly directed to the size of the auditory canal and the condition of its wall. Every little scale of epidermis or mass of cerumen that can possibly hide an abnormal condition should carefully be removed by means of a cotton-tipped probe. The observer's eye should next seek the umbo or depression near the center of the drum-head, and the glance should then be directed upward along the handle of the malleus until Shrapnell's membrane is brought into view. This portion of the membrane should receive the most careful scrutiny, an effort being made to discover, if possible, the presence of the so-called foramen of Rivini or anything abnormal in this region. Attention should next be directed to the condition of the anterior and posterior folds, after which the glance of the observer should be directed around the periphery of the drum-head. By observing always this or some other definite plan of examination during otoscopy it will hardly be possible that any abnormal condition of im- portance will escape the observation. Particular attention should be directed to the size, shape, and position of the cone of light, the apparent length and position of the malleus handle, and the degree of prominence of the short process; the color, luster, apparent thickness, curvature, and position of the drum-head; as well as the presence or absence of perforations, cicatrices, chalk deposits, localized spots of atrophy or thickening, polypi, abscesses, exudation-cysts, or other pathologic conditions. Changes Occurring in the Curvature of the Membrana Tympani.-The membrana may bulge outward as the result of pressure from fluid within the tympanum or there may be a 380 DISEASES OF THE NOSE, THROAT, AND EAR localized "pointing" of pus at any position on the drum-head. The normal curvature of the drum-membrane depends largely upon the tension of the tensor tympani muscle. It is claimed that the retractile effect of this muscle is increased after death by rigor mortis and in certain conditions the muscle is con- stantly contracted during life to an extreme degree. An unduly depressed condition of the membrana tympani also occurs as the result of unequal pneumatic pressure upon its two surfaces when obstruction of the Eustachian tube inter- feres with the proper ventilation of the tympanic cavity. Sometimes the retraction of the membrane is quite abrupt at points near the periphery, so that a sort of terrace is formed at Fig. 164.-Retracted membrane of a girl of ten years, with long-standing nasal and tubal obstruction, showing foreshortening of malleus handle, prominence of the posterior fold, and visibility of the margin of the pocket of von Troltsch as it passes forward to the manubrium. The light spot is shortened, and beyond it anteriorly are two parallel curvilinear bright lines, marking the edges of abruptly depressed areas of the drum-head, one within the other (Randall). Fig. 165.-Left membrana tympani of a boy of six years, with nasal and tubal obstruction. The manubrium is drawn up almost out of sight; the tip being higher than the short process; behind it the incudostapedial joint is visible, and below and posteriorly the dark niche of the round window is discernible. There is a faint reflection of light near the normal position, and a stronger one on the promontory near the stapes (Randall). Fig. 164. Fig. 165. that point. Under such circumstances a bright line will be seen at the point where the abrupt change of curvature occurs. Should such an abrupt change of curvature occur at the posi- tion of the cone of light, it will appear as if broken transversely into two parts, that nearest the periphery assuming a cres- centic shape. Whenever the membrane is retracted as a whole there is usually some change in the light spot. It often loses the triangular form, because of which it has received the name "cone" or-"pyramid of light," and becomes narrow, reduced to a mere point, or perhaps entirely disappears. DISEASES OF THE MIDDLE EAR 381 The posterior fold becomes large and prominent when the drum-membrane is greatly retracted and the malleus handle foreshortened (Fig. 164) or displaced, usually backward (Fig. 165). The two diagrams (Figs. 166, 167) represent the means by which the apparent shortening of the malleus handle is produced. Myringitis is an inflammation of the membrana tympani, characterized by congestion, swelling, and sometimes ulcera- tion of the membrana tympani,pain, and tinnitus; but hearing is not greatly impaired unless the inflammation also involves the entire tympanic cavity. The pain is increased by move- ments of the jaw, pressure in front of the tragus, or traction Fig. 166.-Diagram of the normal position of the malleus and membrana tym- pani. The apparent length of the malleus handle to the eye of an observer is rep- resented by the distance a-b. Fig. 167.-Diagram of a retracted membrana tympani, showing the malleus handle drawn backward until its tip is in contact with the promontory. The apparent length of the malleus handle to the eye of an observer is represented by the distance a-c, the apparent length of the malleus handle having been "fore- shortened" about one-half. Fig. 166. Fig. 167. upon the auricle; it is generally shooting rather than throbbing in character. Etiology.-'The commonest cause of myringitis is exposure to cold, especially the direct impact of a cold wind upon the membrana tympani in persons whose auditory meatus is unduly open. It is sometimes the result of direct violence, as, for example, a blow upon the auricle or the impact of a wave in surf-bathing. In some cases the etiology is obscure and the disease seems to be the result of struma or of the rheumatic or gouty diathesis. 382 DISEASES OF THE NOSE, THROAT, AND EAR Symptoms.--Severe pain, shooting in character, tinnitus, and more or less deafness. Upon inspection, if the disease is seen in its earlier stages, the membrane will be found markedly congested at the periphery and behind the malleus handle. Large vessels will be seen in these positions and radiating branches will extend from the blood-vessels behind the malleus handle to inosculate with those coming from the periphery. The surface of the membrane becomes lusterless and rough from loosening of its epithelium, and thick and opaque and of a uniform reddish color from infiltration and increased congestion, until all land- marks except the short process of the malleus handle are hidden from view, this too finally disappearing beneath the swelling, the membrane being, at this stage of the disease, of a lively red color and apparently either flat or actually convex in form. As the integument in the neighborhood of the drum-head is also congested, it is difficult to make out its boundaries, the red and convex membrane appearing not unlike a polypus projecting into the canal, for which it has been mistaken. In the course of the disease the epidermis exfoliates, wholly or partly, and there appears an abundant secretion, which is at first serosanguineous, but later becomes purulent. Exudation- cysts, filled with serum or pus, sometimes appear upon the surface of the drum-head. Pressure with a probe will indent such collections of fluid between the layers of the drum-head, and the indentation will remain visible for some time (Fig. 168), which is not the case in localized pointings of pus from within the tympanum. If abscesses rupture or are incised, ulcers result, which may either heal or perforate the drum-head. As the inflammation subsides, the portion of the membrane at the umbo is the first to resume its normal appearance. The periphery of the drum-head and a triangular portion, whose Fig. 168.-Interlamellar abscesses of right mem- brana tympani, one at umbo showing the pitting caused by pressure of a probe. Three others are seen down and forward (Schwartze). DISEASES OF THE MIDDLE EAR 383 base includes Shrapnell's membrane and whose apex is at the tip of the malleus handle, remain red and swollen for some days. Finally, the swelling and congestion disappear from these parts of the membrane, the light spot becomes distinct, and the drum- head assumes its normal appearance. Relapses are not infrequent or an acute attack may assume the chronic form of the disease. Treatment.-In acute cases pain may be relieved by the appli- cation of leeches and afterward by the use of hot fomenta- tions. When a discharge appears the parts should be thor- oughly cleansed by means of a dossil of cotton dipped into hy- drogen peroxid and the membrane should be covered with a thin coating of powdered boric acid. In traumatic cases the pain and congestion rapidly subside under i-drop doses of tincture of aconite root administered every hour. A 4 per cent, solution of cocain should meanwhile also be dropped into the auditory canal sufficiently often to keep the parts moistened until the pain subsides. Chronic Myringitis.-Chronic inflammation of the drum- head is practically always present in chronic otorrhea origi- nating in the tympanic cavity. In such cases the chronic myringitis is part of the intratympanic inflammation and gen- erally subsides after the discharge has ceased. The perforation, if not too large, then closes spontaneously or can be made to close by one of the methods described in the section on Per- forations of the Membrana Tympani. However, chronic myringitis is occasionally encountered without a history of previous middle-ear otorrhea, and then generally is part of a chronic inflammation involving at least the deeper portion of the auditory canal. Etiology.-Gout, rheumatism, or struma may account for the cases of chronic myringitis when there is no history of a previous otorrhea. Most cases are, however, the heritage of a middle- ear suppuration, and in cases where there is a scanty fetid dis- charge in the fundus of the canal it is well to inspect the poste- rior upper quadrant of Shrapnell's membrane closely for a 384 DISEASES OF THE NOSE, THROAT, AND EAR fistula leading into the attic before being satisfied that the drum-head is intact. Symptoms.-The subjective symptoms are a sensation of fulness and itching within the ear. As the drum-head has little to do with the function of hearing, the hearing in these cases is only slightly impaired unless the intratympanic structures are involved. There is sometimes a very scanty fetid discharge. This discharge adheres to the drum-head and collects in small amounts upon the adjacent lower portions of the canal. When wiped away with cotton and peroxid the drum-head is reddened, either as a whole or in spots where the epithelium has ex- foliated. Some of these areas mark the position where a minute abscess has ruptured and may be covered with granu- lations or minute polypi. In cases where there is no discharge the drum-head lacks luster and is rough from the loosening of its epithelium. The color of the drum-head varies, according to the degree of the inflammation, from a dull red to a yellow or dirty white. It is no longer translucent, but is thick and opaque. The cone of light is absent or small and distorted. Prognosis.-'The course of the disease is slow. Chalk de- posits and areas of localized thickening or atrophy are not un- commonly seen when the disease has run its course. Treatment.-When chronic myringitis is part of an inflamma- tion of the other anatomic structures of the tympanum the treatment is largely that of the intratympanic condition. In cases where there is a discharge from the dermic surface of an intact drum-head, this should be cleansed carefully by syringing first with warm water and afterward with sublimate solution. The canal should then be dried thoroughly by means of absorbent cotton wrapped about the end of an Allen probe and painted with a 12 per cent, solution of silver nitrate. Abscesses, if present on the drum-head, should be evacuated and the interior of the abscess touched with silver nitrate by means of a bead of the salt fused on the end of a probe. Granular spots and small polypi upon the drum-head should receive special attention. Where the granulations are small, DISEASES OF THE MIDDLE EAR 385 simply thoroughly applying at intervals of three or four days a 12 per cent, solution of silver nitrate is sufficient to bring about a cure. When the granulations are larger and coarser it will be necessary to destroy them with a 50 per cent, solution Fig. 169.-Hartmann's foreign body and polyp forceps. of chromic acid or by touching them with trichloracetic acid- These applications should be made with care, so that no drip of acid is allowed to flow or spread beyond the bounds of Fig. 170.-Politzer's ear forceps. the granular area. Polypi too small to be removed with a snare should be scraped away from their place of origin on the mem- brana with Buck's sharp curette or removed by means of Hart- mann's curette forceps (Fig. 169). 386 DISEASES OF THE NOSE, THROAT, AND EAR In cases where the granulations on the drum-head are coarse or a small polypus has been removed, the patient should be in- structed to drop into his ear 95 per cent, alcohol (Formula 16), diluted if necessary, every three hours between his visits to the aurist. Silver nitrate in strong solutions was extensively used by the aurists of half a century ago as an application to the drum- head. Wilde believed that it brought about exfoliation of the dermic layer of the membrana and thus diminished its thick- ness. While the views of this distin- guished Dublin aurist are not in harmony with modern teaching, yet it is probable that the silver oxid deposited upon the dermic layer of the drumhead as the result of applications of nitrate is partly absorbed by the deeper structures, acts as a seda- tive, and promotes the absorption of in- flammatory products. For cases that result from a rheumatic or gouty diathesis, alkalis, with iodid of potassium or salicylate of sodium, should be prescribed, while for cases where the disease results from struma or debility, the use of tonics and cod-liver oil and the employment of hy- gienic measures should be advised. Deposits of chalk (Fig. 171) are usually the result of long- continued inflammation of the membrana tympani. Their presence does not indicate that the patient has the gouty dia- thesis. Only when large do they greatly interfere with the acuteness of hearing by stiffening the drum-head and inter- fering with its vibrations. Rupture of the drum-head may result from the direct impact of a foreign body or from the instruments used in extracting a foreign body. Many cases are the result of the sudden com- pression of the air in the auditory canal produced by falls or blows upon the ear: during war the discharge of large cannon when the patient occupies a position near the mouth of the Fig. 171.-Calcareous deposits in the drum- head after middle-ear inflammation (Spald- ing). DISEASES OF THE MIDDLE EAR 387 gun; and when the membrane is diseased, from the use (abuse) of Politzer's air-douche, Siegle's pneumatic speculum (probably the more dangerous instrument), and even from violently blow- ing the nose. The writer observed a case of this kind in an old lady of about seventy, whose drum-head, aside from the usual senile changes, so far as could be judged by her history and the appearance of the other drum, was normal previous to the accident. Another case was that of a robust young man who attributed his ruptured drum-head to a kiss on his ear. The drum-head may or may not be ruptured in fractures of the base of the skull. Even in such cases, where there is hemorrhage from the meatus, the blood may come through the roof of the canal and the membrana tym- pani be intact. Injury to the drum-head may result from contrecoup or be explained by the irradia- tion theory of Aran. One of the writer's cases, a lad of about sixteen years, exhibited rupture of both drum-heads as the result of a blow from a baseball received on the left mastoid. It is stated that gunshot wounds of the mastoid may cause rupture of the drum-head apparently as the result of the jar from the impact of the bullet. However, it should be remarked in this connection that a hard blow from the bare fist on the ear is far less likely to produce rupture of the drum-head than a lighter blow from the palm of the hand or a boxing glove, the rupture in the latter case resulting from the condensation of air in the canal. In rupture of the drum-head resulting from the concussion of cannon shots, bursting shells, etc., there is apparently, if one may judge by the stellate scars seen in cases where the victims have escaped with their lives, actually a tearing out of a portion of the drum-head, usually just below the tip of the malleus. The subjective symptoms are sudden deafness, tinnitus, vertigo, and hemorrhage or a serous discharge from the ear. Fig. 172.-Rupture of the antero-inferior half of the drum-head, caused by a box on the ear (after Politzer). 388 DISEASES OE THE NOSE, THROAT, AND EAR The prognosis as regards the restoration of hearing depends upon the amount of damage done to the other structures of the ear. Most uncomplicated cases recover satisfactorily and speedily, but sometimes purulent inflammation of the middle ear follows as the result of the injury or injudicious treatment. Treatment.-Cleanse the external auditory canal carefully, so as to remove all blood-clots or other material that might favor the growth of bacteria. Use Politzer's air-douche if necessary to remove blood from the middle ear or little shreds remaining between the edges of the wound to retard union; apply by means of the powder-blower a thin layer of boric acid upon the drum-head, and let the ear entirely alone until the heal- ing process is complete, unless pain or the appearance of a purulent discharge renders further interference necessary. Perforation of the membrana tympani sometimes occurs as the result of ulceration from the dermic surface of the drum- head during an attack of acute myringitis. Under such cir- cumstances the ulcer is usually central. The commonest cause, however, of perforation of the membrane is ulceration from within, the result of otitis media purulenta. Symptoms.-'Examinations by means of the concave mirror and speculum usually discloses the presence of the perforation, which, if large, is readily seen. In most cases inflation of the middle ear by the Politzer method produces a characteristic "perforation whistle," heard by means of the auscultation-tube (Fig. 148). Indeed, the perforation whistle is often so loud that it can be heard at a distance of many feet from the patient. If suppuration of the middle ear is present pus will escape through the perforation in the form of bubbles during inflation. The subjective symptoms vary according to the size and posi- tion of the perforation and other diseased conditions of the ear that may be present. A perforation of Shrapnell's membrane (Fig. 173), when it has been present for some time, is usually accompanied by considerable hardness of hearing, because purulent inflammation of the attic, the commonest cause of DISEASES OF THE MIDDLE EAR 389 perforation in Shrapnell's membrane, generally involves the articulations of the ossicles and produces lesions which greatly impair the acuteness of hearing. When the perforation is near the center of Shrapnell's membrane the neck of the malleus is exposed, while the perforation through the anterior portion of the drum-head, being directly over the tympanic extremity of the Eustachian tube, yields a loud perforation whistle. Rivini has described a perforation or foramen existing in the mem- brana flaccida as a normal condition. Although such a "fora- men" is frequently seen just above the process, it is believed by most aurists to be pathologic. When a large perforation in the membrana vibrans involves a consider- able part of the malleus handle the tip of this process is usually destroyed by necrosis; should, however, the malleus handle become attached to the promon- tory, this does not occur. Large per- forations may exist in the membrana vibrans without the hearing being greatly impaired, unless the perforation be so placed as to impair the support that the membrana normally gives to the ossicles. Prognosis.-Perforations of considerable size permit free access of dust, cold, moisture, and other irritants into the tympanic cavity, and predispose the patient to recurring attacks of otitis media. Sometimes the perforation gradually becomes closed by cicatricial material. Indeed, nearly the whole drum-head may be replaced in this manner. But, although the tympanic cavity is by this means protected from cold or dust-laden air, the acuteness of hearing is generally more or less impaired if the surface of cicatricial tissue be large, and such cicatricial areas break down readily during attacks of acute catarrh of the middle ear. Fig. 173.-Right mem- brana tympani of a boy of five years, with constant discharge for three years. A perforation about 1.5 mm. in diameter is with difficulty seen above the short proc- ess, and intratympanic in- jections bring away epithe- lial flakes and masses of fetid secretion. The rest of the membrane is slightly opaque, thickened, and in- jected (Randall). 390 DISEASES OF THE NOSE, THROAT, AND EAR When seen by reflected light cicatricial areas appear some- what depressed below the level of the rest of the drum-head, and are sometimes so transparent that the structures within the tympanum are readily discernible through them (Fig. 174). If rarefaction of the air within the auditory canal is produced by Siegle's pneumatic speculum, a cicatrix will be seen, to move farther outward than the rest of the membrane. When large and very thin and lax, a "ballooning" of the cicatrix results from inflating the middle ear by means of Politzer's air- douche (Fig. 175). Fig. 174. Fig. 175. Fig. 174.-A large rounded loss of substance of the membrana tympani below reaches up to the tip of the manubrium, which projects slightly into the upper margin. It is closed by a delicate cicatrix applied to the promontory and molded upon its inequalities. The edges of the depression are sharp cut and overhang, so that the area seems an unclosed perforation (Randall). Fig. 175.-Inflation of the middle ear forces the delicate cicatrix out like a bubble into the meatus, where it seems larger than the opening and hides its edges and the handle of the malleus. In a few minutes the distended sac loses its tension and becomes plicated as it collapses, soon to resume its old position in contact with the inner tympanic wall (Randall). Treatment.-When all discharge has ceased from the tym- panum an effort should be made to close the perforation in order to prevent the irritating effects of dust and cold upon the exposed intratympanic mucous membrane. Closing of the perforation, when small, can be brought about by rubbing its edge from time to time with a few fibers of absorbent cotton wrapped about the end of an Allen probe and saturated with fuming nitric acid. The acid destroys the epidermal scales or cells which otherwise would extend from the external or dermal surface of the drum-head and prevent the growth of granula- tions. By keeping the edge of the opening in the drum-head "raw"-that is, free from epidermis-by means of the acid, the granulations finally unite in the center of the perforation, which then becomes closed. The same thing can usually be DISEASES OF THE MIDDLE EAR 391 accomplished by the method devised by Blake, which consists in placing a little disk of writing-paper over the perforation. A disk of sufficient size to cover the opening is cut from ordi- nary writing-paper and is soaked for a few moments in corrosive sublimate solution (i :5ooo). It is then placed on the end of a cotton-tipped Allen probe and carried through a speculum to the drum-head over the perforation. It adheres somewhat firmly to the edge of the perforation because of the sizing or glue which all writing-paper contains. The paper disk acts as a stimulant and support to the granu- lations springing from the edge of the perforation, so that they finally unite in the center and the opening is closed. It is somewhat instructive to note from week to week the changing position of the disk of paper. Roughly speaking, the epidermal scales grow from the center of the drum-head toward its periph- ery, and thence outward along the canal, and hence the disk or paper which was placed over the perforation in the drum- head, within a few weeks is seen to be upon the wall of the canal. If, in the meanwhile, the perforation in the drum-head has not closed, another disk of paper should be placed over it, and so on until the perforation has closed. When a perforation is so large that the support of the tym- panic membrane to the ossicles is destroyed, the chain of small bones tends to sag outward by its own weight, and the acute- ness of hearing is considerably impaired. If the Toynbee artificial membrana tympani (Fig. 176) be so placed as to give the requisite amount of support when this condition exists, considerable improvement of the acuteness of hearing will result; but little disks of paper, linen, silk, or compressed cot- ton answer a still better purpose, and a thread may be passed through the center of such a disk to facilitate its removal from the auditory canal. Gruber has contrived an apparatus (Fig. 177) for the introduction of such artificial drum-mem- branes by the patient himself, who, after a little preliminary instruction, can usually introduce one in a manner to secure the greatest increase of the hearing power. It is astonishing 392 DISEASES OF THE NOSE, THROAT, AND EAR how tolerant the ear sometimes becomes to the presence of such objects, which can often be used for a long time without any deleterious results. It is not a matter of indifference as to the material employed in the manufacture of the artificial drum-heads. Some patients hear best with disks made from one material, some with those made from another. Fig. 176.-Toynbee's artificial drum-head. Fig.. 177.-Contrivance for intro- ducing artificial drums (Gruber). When a large cicatrix is present which bulges greatly after inflation-i. e., is very freely movable--the hearing can often be improved greatly by the application of a small quantity of contractile collodion (Formula 78). The collodion is best applied by means of a small camels'-hair brush after the infla- tion of the tympanum. The application of collodion should not be repeated at too frequent intervals or too much applied at one time, because pain and myringitis may result. Otitis Media Catarrhalis Acuta.-Acute catarrhal inflam- mation of the middle ear is an acute inflammation of the mu- DISEASES OF THE TYMPANUM DISEASES OF THE MIDDLE EAR 393 cous membrane of the tympanum, Eustachian tube, and, some- times, of the mastoid cells, characterized by increased secretion of serum or mucus, but not of pus. Clinically, cases of acute catarrh of the middle ear are divided into two classes: One in which the attic of the tympanum and mastoid antrum are involved by the diseased process; the other, in which the dis- ease is confined to the Eustachian tube and atrium of the tym- panum. Etiology.-The disease is in almost all instances the result of exposure to cold. Chronic catarrhal affections of the upper respiratory tract render many individuals susceptible to recur- ring attacks of inflammation of the middle ear, while in many instances carious teeth have the same effect. Very often pain commencing as a toothache extends to the ear. In many cases the disease is the result of surf-bathing or of diving into water from a considerable height. In cases where acute catarrh results from diving and surf- bathing the direct impact of water upon the drum-head pro- duces sufficient traumatism to cause the disease. A large auditory meatus, a cicatricial drum-head, or a perforated drum render the middle ear more liable to traumatism while bathing, and such individuals should never dive or bathe in the rough surf without stopping the ears with absorbent cotton saturated with vaselin to exclude the water. All amphibious animals have valves which exclude water from the auditory canal dur- ing the time the animal is under water, and hunting dogs taught to dive sooner or later become deaf. However, it is not always the forcible entrance of even cold water into the auditory canal that is responsible for an attack of acute aural catarrh. Not infrequently in surf-bathing a wave will strike a bather in the face at a time when he is swallowing or performing some other function that opens the Eustachian tubes, and under such circumstances the water sometimes penetrates as far as the tympanum, and if not speedily removed is capable of causing acute intratympanic inflammation. An accident of this kind once occurred to the writer and was accompanied by a certain 394 DISEASES OF THE NOSE, THROAT, AND EAR amount of vertigo and syncope, and it seems not improbable that some cases of drowning may be the result of the entrance of water into the ears during surf-bathing or swimming in rough water. Occasionally fluid used as a nose-wash penetrates the Eustachian tubes and occasions acute tympanic catarrh or even suppuration, although the wash may be as bland and unirri- tating to the nasal mucous membrane as the normal salt solu- tion. Bland oils may be thrown into the Eustachian tube with impunity, but watery solutions frequently cause mischief. The use of such contrivances for cleansing the nasal mucous membrane as Thudicum's douche, the Bermingham douche, etc., are by no means as safe as an atomizer, and acute catarrh of the middle ear has resulted from simply sniffing normal salt solution into the nose and blowing the nose forcibly immediately afterward, so that some of the fluid reached the tympanum. Should water reach the tympanum during bathing or a watery nose-wash be inadvertently injected into the middle ear while cleansing the nose, Politzer's or Valsalva's method of inflation immediately should be employed sufficiently often to free the middle ear from the fluid. The exanthematous fevers, and occasionally typhoid and tuberculosis, operations in the posterior portion of the nares, in the postnasal space, and even upon the tonsils occasionally cause acute otitis. Pathology.-The affection in most cases begins as a catarrh of the pharyngeal orifices of the Eustachian tubes, accompany- ing similar disease of the nose and nasopharynx. If the pharyn- geal orifices of the Eustachian tubes are inspected by means of the rhinoscope at the beginning of an attack, the mucous mem- brane of the tube mouths will be found so congested and swollen as to either completely close the tubes or at least greatly inter- fere with the proper ventilation of the middle ear. Later on the secretions from the tubes are abundant, becoming more consistent in most instances as the disease advances, so that a bulb of thick glue-like mucus may project from the orifices of DISEASES OF THE MIDDLE EAR 395 the Eustachian tubes into the pharynx. The mucous follicles are sometimes swollen, giving a granular appearance to the tube lips. The appearance of the membrana tympani varies somewhat at the commencement of the disease. Generally it is pinkish in color, as the result of the congestion of the inner or mucous layer, and the manubrial plexus of blood-vessels is congested. Often the membrana is more dull and opaque than it is nor- mally. Often a line as fine as a hair, extending across the drum-head, indicates the upper level of the fluid within the tympanum (Fig. 178). If the fluid within the tympanum is thin and mobile, it will be seen to alter its position with the Fig. 178.-Collection of fluid exudate in the lower part of the tympanum, marked by a glistening line across the membrane. From the right ear of a young man in the middle of an acute coryza. _ Cure by Politzeration (Politzer). Fig. 179.-Foamy secretion in the tympanum after inflation, in a case of serous accumulation. From a patient with acute nasopharyngeal catarrh (Politzer). Fig. 178. Fig. 179. movements of the patient or during the use of the pneumatic speculum. By inflating the middle ear by the Politzer method the fluid can sometimes be broken into foam and the dim out- lines of minute air-bubbles discerned through the drum-head (Fig. 179). The bacteria found in the secretion varies. However, there is practically never a mixed infection. The staphylococcus and the pneumococcus of Friedlander probably are the forms most commonly present. The prognosis under appropriate treatment is favorable. Most cases completely recover. In neglected cases, however, the disease often assumes the purulent form or relapses into the chronic condition. 396 DISEASES OF THE NOSE, THROAT, AND EAR Symptoms.-Generally, there is pain increased by movements of the jaw, pressure over the tragus, or gently pulling the auricle outward. Hardness of hearing will be greater than in simple myringitis, if, indeed, myringitis ever occurs without the in- flammation involving, to a certain extent, the entire mucous membrane of the middle ear. There will be present tinnitus and perhaps vertigo. The entire membrane may be flattened or even bulging as the result of the pressure of fluid within the tympanum. The color of the membrane may be nearly normal in appearance. There may be more or less congestion about the periphery or the region of the malleus handle. In the later stages of the disease, if rupture of the drum-head be delayed, the swelling of the drum-head is so great that the out- line of the malleus handle is lost to view and the drum-head is not distinguishable by color from the surrounding red and swollen skin of the canal. Treatment.-In most cases of acute catarrh of the middle ear, if seen early, it is advisable to prescribe | gr. of calomel combined with 5 gr. of the bicarbonate of sodium, to be taken every hour for six hours, for the double purpose of securing free evacuation of the bowels and the alterative effects of the calomel, as it has been maintained that small, frequently re- peated doses of calomel have the power of controlling inflam- mation of mucous membranes. The pain is often relieved by the use of leeches. It is cus- tomary, in cases where there is severe pain, to apply at least three leeches, one in front of the tragus, one on the mastoid as close to the auricle as possible, and one just beneath the auricle in the angle between the jaw and the mastoid process. These points are selected because they are the positions where the circulation of the middle ear is most readily depleted. The leeches should be the largest procurable and the wounds should be encouraged to bleed for a time after their removal. A half-century ago leeches were much more freely used in the treatment of acute aural catarrh than at present. Some writers of this period recommend that as many as ten leeches DISEASES OF THE MIDDLE EAR 397 be applied to the margin of the auditory canal in relays; that is, as fast as one leech filled and dropped off a fresh leech was applied as nearly as possible to the same spot. It is certainly true that in order to relieve the pain of acute catarrh of the middle ear or myringitis the blood-letting should be somewhat free and that little relief will follow the use of less than three leeches. The use of leeches in the hyperemic stage of acute otitis media when the pain is severe will not only relieve the pain but also will often cut short the progress of the inflamma- tion. After the use of leeches hot applications should be made to the ear. This can be done by filling the auditory canal with hot water and afterward applying a hot flaxseed poultice over the auricle, but in most cases the pain is more quickly and com- pletely relieved by the instillation of anodynes into the ear and the application of dry heat. The patient may lie with the affected ear upon a hot-water bag or a bag of hot salt, or i or more drops of a 4 per cent, solution of cocain be placed within the auditory canal from time to time. In some cases, however, a combination of morphin and atropin seems to act better as an ano- dyne than cocain. A hypodermic tablet of atropin and mor- phin may be dissolved in a few drops of warm water and dropped into the ear. It is best to use a certain amount of caution in the use of powerful narcotic poisons within the audi- tory canal, as cases of poisoning havebeen reported. It is a safe rule never to drop into the auditory canal a larger amount of atro- pin or morphin than can safely be administered by the stomach. It should be borne in mind in using anodynes within the ear that when the mucous membrane of the middle ear is exposed watery solutions are more readily absorbed than oily solutions or ointments, but that the contrary is the case when the drum- head is intact and absorption must take place through the sur- face of the skin; also that inflamed surfaces, whether of skin or mucous membrane, absorb anodynes much more slowly than when no inflammation is present. A 3 per cent, solution of cocain painted upon the exposed mucous membrane of the 398 DISEASES OE THE NOSE, THROAT, AND EAR middle ear quickly relieves the pain of tympanic neuralgia, and more slowly that of active inflammation, but where the drum-head is intact a io per cent, ointment of cocain and lan- olin will give greater relief from pain than a watery solution. However, painting the drum head with equal parts of cocain, menthol and phenol is better than either solutions or oint- ments of cocain (Formula n). When fluid is present within the tympanum an attempt should be made to evacuate it by the use of the Politzer air- douche. The nose and nasopharynx should first be cleansed by the spray from an atomizer containing an alkaline solution and a piece of absorbent cotton, saturated with a 4 per cent, solution of cocain, inserted within each nasal chamber. After contraction of the turbinated bodies has been secured, the nasal chambers and the vault of the pharynx should be sprayed with a 4 per cent, solution of antipyrin to maintain the effects of the cocain for several hours and relieve congestion of the pharyn- geal lips of the Eustachian tubes. The Politzer air-bag should now be filled with the vapor of menthol-chloroform and used with no more force than is necessary to free the tube and middle ear from mucus. This treatment should be repeated once or twice a day, omitting the use of the cocain and antipyrin if the nasopharyngeal mucous membrane be not sufficiently swollen to require it. If, notwithstanding antiphlogistic and other measures, there is bulging in the tympanic membrane, with indications that a perforation is likely to occur, it should be punctured by a para- centesis needle at the most prominent point of bulging or in the postero-inferior quadrant. This operation is harmless if antiseptic precautions be observed. The canal should be cleansed by wiping it out with a pledget of cotton wrapped about an Allen probe saturated with hydrogen peroxid. It should then be syringed gently with warm corrosive sublimate solution (1 :2ooo). After being sterilized, a knife (Fig. 189-5) should be thrust through the membrane. If the malleus handle is not invisible as the result of swelling, the operator DISEASES OF THE MIDDLE EAR 399 should make the puncture on a level with the tip of the malleus handle midway between it and the periphery of the drum-head, and cut downward as far as possible while the knife is being withdrawn. If this technic is observed it will tend to avoid puncturing the bulb of the jugular vein, which in some cases lies immediately beneath the mucous membrane of the floor of the tympanum, without an intervening lamina of bone. Should the vein accidentally be punctured the hemorrhage for a moment may be quite free, but is readily controlled by pack- ing the canal with iodoform gauze. Puncturing a normal drum-head after the parts have been cocainized is not a very painful procedure, but when inflamed, paracentesis causes severe pain even after the fundus of the canal has been most carefully cocainized (Formula 11). There- fore, if the operation is performed without a general anesthetic, it should be done with the utmost quickness. The thrusting of the knife through the drum-head is sometimes followed by the escape of air with an audible hiss. At other times there is an escape of fluid which quickly fills the entire canal, but in some cases there is little fluid secreted for some hours after the operation. The canal in either case should be stopped with a loose plug of sterile iodoform gauze, which should be changed as often as it becomes saturated by secretions. The relief from pain occurs in some cases within a few mo- ments after the operation. In other cases an hour or more elapses before the pain begins to subside. There are few cases where no relief from pain is afforded by the operation. Without general anesthesia the simple, straight incision, quickly done, is all that most patients will permit. Under ether the incision may be made to extend around one-third of the posterior periphery, or a large V-shaped flap involving the posterior half of the drum-head may be made. These large incisions afford better drainage, but, as a matter of fact, they close almost as rapidly as smaller incisions. When the attic is inflamed and there are symptoms of commencing mastoiditis, a thrust upward through Shrapnell's membrane posterior to 400 DISEASES OF THE NOSE, THROAT, AND EAR the short process sometimes affords the relief from pain that paracentesis of the membrana tensor failed to secure. As the knife is withdrawn, its point should be kept in contact with the bone of the roof of the canal for about | inch in order to cut periosteum of this region. Otitis Media Catarrhalis Subacuta.-The name is some- times applied to that stage of catarrhal disease intermediate between the acute and chronic forms. However, by subacute catarrh of the middle ear or simple acute otitis media is gener- ally meant an inflammation less severe in type than the acute. Pain is neither severe nor long continued and the patient is deaf only for a short time. The attacks occur at frequent intervals. Upon examination the membrana tympani is found pinkish in color and is decidedly opaque and lacks its usual luster. The cone of light is either smaller than normal or has entirely disappeared. As the drum-head never ruptures, permitting an examination of exudates, the kind of bacteria present if any is a matter of conjecture. It is doubtful if any be present. Etiology.-The disease is commonest in children as the result of disease of the nose andpharynx, hypertrophied pharyn- geal tonsil being an exceedingly common cause of the affection. Bad nutrition, carious teeth, and frequent attacks of coryza are common predisposing causes. The treatment should be directed toward improving the pa- tient's general health and removing any predisposing cause of the affection. If the teeth are carious they should receive the attention of a skilful dentist, while the efforts of the aurist should be carefully directed toward the removal of any morbid condition existing in the nose and nasopharynx, because ex- perience has amply demonstrated that in most cases attacks of subacute aural catarrh cease to recur as soon as a cure is brought about of the concomitant nasopharyngeal disease. The knowledge of this fact, however, is not an excuse for neglect- ing local treatment of the ears while the nose and nasopharynx are receiving attention. Adenoid growths and hypertrophied faucial tonsils should re- DISEASES OF THE MIDDLE EAR 401 ceive appropriate treatment in the manner already described. At each biweekly or triweekly visit of the patient the nose and nasopharynx should be cleansed by means of an atomizer filled with an alkaline solution, after which the ears should be carefully inflated by means of Politzer's air-bag. If the in- flammation of the middle ear is not too active, "massage" should be applied to the drum-head and the ossicles by the aid of Siegle's pneumatic speculum, after which there should be made to the interior of the nose and nasopharynx an applica- tion of an iodin solution (For ula 112) in the case of children, or an astringent solution (Formulas 113, 114) in the case of adults, and the parts covered with albolene by means of the spray from an atomizer. The hygienic surroundings of the patient should receive care- ful attention and tonics and cod-liver oil prescribed in suitable cases. In children catarrhal inflammation is generally of an adenoid character; that is, the lymphatic elements of the mucous membrane bear the brunt of the disease, so that chil- dren and young adults do well upon iodin compounds applied locally and given internally. Syrup of the iodid of iron should be prescribed for internal use, with or without cod-liver oil, as the circumstances of the case require, while hypertrophy of the lymphatic glands underneath the skin of the neck should be treated by inunctions at bedtime of a 10 per cent, ointment of ichthyol in lanolin. The ointment should be rubbed lightly into the skin and the bed-clothing protected by waxed paper and a bandage about the child's neck.. Catarrh in adults is often characterized by inflammation of the mucous glands and interstitial elements of the mucous membrane; and it is in such cases that sedative applications and astringents are most useful. The vapors of various volatile substances are sometimes applied to the middle ear by means of Politzer's air-bag. The most useful of these substances are iodin, menthol, and chloroform. Glass-stoppered bottles, each partly filled with one of these drugs (Formulas 80 to 83), should be at hand in the office, so that the Politzer air-bag 402 DISEASES OF THE NOSE, THROAT, AND EAR can readily be filled with the vapor of the drug which it is desired to use by inserting the nose-piece of the instrument within the neck of the bottle. The vapor can then be made to reach the mucous membrane of the middle ear by Politzer's method or by the employment of a Eustachian catheter. The vapor of iodin, when thrown into the middle ear, acts as an alterative and gentle stimulant, that of menthol as a sedative, while chloroform vapor is probably simply a stimulant. It is generally easier to inflate the middle ear when the air-bag is filled with chloroform vapor than when it contains simply air. Otitis Media Catarrhalis Chronica.-Chronic catarrh of the middle ear is a chronic non-suppurative inflammation of the mucous membrane and submucous tissues of the middle ear, producing deafness, tinnitus, and sometimes vertigo and other symptoms of altered auditory functions. Pathology.-There are two forms of the disease, the adhesive and the interstitial, where lime deposits occur in the vessels and osteomyelitic changes take place in the ossicles and labyrinthine capsule, causing ankylosis and closure of the fenestra. Gradual progressive changes take place in the mucous membrane and submucous tissues of the middle ear, similar in character to those that occur in the mucous mem- branes of other parts of the body. There is first hyperemia and hypertrophy, then hyperplasia, and finally sclerosis. The first stage of the disease is a dilatation and engorgement of the capillaries, with an exudation of serum and round cells, both from the surface of the mucous membrane and also into its substance. The capillaries are engorged, the mucous mem- brane is swollen and edematous; an exudate is constantly moistening its surface. The inflammatory exudate within the substance of the mucous membrane contains round cells, which proliferate and increase in size by a process of elongation, so that they are finally converted into newly formed connective tissue, sometimes causing cords, bands, contractions, and calcifications similar in appearance to cicatricial tissue follow- ing suppuration. DISEASES OF THE MIDDLE EAR 403 During the earlier stages of the disease the thickened mucous membrane is redder and rougher than normal, soft, and easily depressed with the end of a probe. As a result, however, of the gradual increase of connective tissue and the absorption of the more fluid parts of the exudate the mucous membrane, while still much thicker than normal, is pale and quite smooth. This condition represents a stage intermediate between hypertrophy and atrophy of the tympanic mucous membrane. It is hyper- plasia of the mucous membrane. As a mechanical result of the contraction of the newly formed connective tissue the glandular elements of the mucous mem- brane disappear and it finally resembles scar tissue. The mucous membrane becomes smooth, thin, and secretes but little fluid. In some cases atrophy or sclerosis of the mu- cous membrane of the tympanum rapidly oc- curs without any preexisting stages of hyper- trophy. Such cases are often the result of syphilis or they follow purulent inflammation of the mucous membrane with or without per- foration of the drum-head. It should not be supposed that the changes in structure above described progress evenly throughout the entire mucous membrane. Often depressed, scar-like spots of atrophy are seen in the midst of the rough, succulent, and swollen mucous membrane characteristic of the hypertrophic stage of chronic aural catarrh. Not only are the mucous and submucous structures involved in long-continued catarrh of the middle ear, but also the bony structures. The cavity of the tympanum becomes more roomy, and as a result of interference with the nutrition of the parts, chalk deposits take place in the deeper layers of the mucous membrane, in the membrana tympani, the membrane of the round and oval windows, and in the ligaments and cartilages connected with the ossicles. The ossicles frequently become ankylosed, and adhesions form which bind them Fig. 180.-Sche- matic section of a case of attachment of the manubrium to the promon- tory (Politzer). 404 DISEASES OF THE NOSE, THROAT, AND EAR to one another or to the surrounding bony walls of the tym- panum, while bands of newly formed connective tissue may extend across the tympanum or mastoid antrum. The membrana tympani and manubrium occasionally become adherent to the promontory (Fig. 180), sometimes as the result of newly formed adhesions, or from the degeneration of bands of mucous membrane, which normally exist in the embryo and frequently persist during life. Ordinarily, catarrh of the middle ear is but part of a diseased process involving the nose, throat, Eustachian tubes, and mas- toid cells. The stage of the disease and the degree of inflamma- tion may vary in the different parts affected. In most instances the Eustachian tube is the first part of the middle ear affected, as the disease progresses by continuity of structure from the nose and pharynx to the tube. Stenosis of the tube, from swelling of the lining mucous membrane or accumulation of seretions, interferes with the proper ventilation of the tym- panum, thus producing a partial vacuum within the cavity, a constant dry cupping, as it were, of the tympanic mucous membrane, with consequent engorgement of its capillaries. Otosclerosis, rarefying ostitis, spongifi cation or hyper- ostosis of the bony capsule of the labyrinth, is a hyperplasia of the bony capsule resulting in the metaplastic transformation of cartilage into bone and bony outgrowths or hyperostoses. In macerated specimens the newly formed bone is whiter and more porous than that surrounding it. The disease is most noticeable at the fenestra which gradually become narrowed until at the oral window there is complete bony ankylosis of the stapes. The deafness is then great, but the drum-head may be of normal luster and position, a red reflex indicating the con- gestion of the mucous membrane of the capsular or inner wall of the tympanum. Etiology.-It is generally the result of an extension of a simi- lar disease of the nasopharynx through the Eustachian tubes. The chronic condition may become established after repeated attacks of acute catarrhal inflammation of the middle ear. DISEASES OF THE MIDDLE EAR 405 Carious teeth cause chronic catarrh of the middle ear as the result of reflex irritation. The similarity of the pathology of middle-ear catarrh to rheumatism of the joints was pointed out by Toynbee and some of the other aurists of a half cen- tury or more ago. Recently, O'Malley has endeavored to demonstrate that chronic adhesive paracuses in the middle ear is rheumatoid arthritis of the organ of hearing and otosclerosis is osteoarthritis of the stapedial articulation and labyrinth cap- sule. Those constantly exposed to loud noises, as the result of working at certain trades, like boiler-making, are especially prone to lose their hearing. Syphilis, scrofula, and any condi- tion of lowered vitality, inherited or acquired, may be enumer- ated as predisposing causes of the disease. Some observers maintain that otosclerosis is simply the result of a primary in- flammation of the middle ear. However, the majority seem to be of the opinion that the disease of the capsule is primary and that concomitant pathological conditions of the middle ear are secondary or coincident. Heredity is an important factor; but when the tendency to otosclerosis exists, intratympanic inflam- mations greatly accelerate the progress of the disease as in chronic suppuration following scarlet fever, when the slowly increasing deafness is not the result of true otosclerosis. Subjective Symptoms.-There is gradually increasing deaf- ness. The decrease in the power of hearing is, however, by no means uniform. Successive attacks of subacute exacerbations of the catarrhal inflammation produce comparatively great impairment of the hearing power, which, in turn, somewhat improves. In this manner the disease progresses, the hearing being better or worse from week to week, but becoming gradu- ally more impaired from year to year. Patients hear better during clear, dry weather than on rainy or damp days. This is not the result of any change in the acuteness of hearing, but simply due to the fact that dry, cold air is a better conductor of sound than moist air. The acuteness of hearing may not decrease to the same degree for all sounds. Many patients bear a watch tick at almost the normal distance, but hear 406 DISEASES OF THE NOSE, THROAT, AND EAR spoken words very indistinctly. In other cases the impair- ment of hearing is most manifest for musical tones, like those emitted by a tuning-fork. A common remark from some patients is that they hear the sound of the voice distinctly, but are unable to distinguish the words spoken. This slow hearing is probably due to the sluggish action of the tensor tympani and stapedius muscles, whose action changes the tension of the ossicular chain, so that under normal conditions it is instantly tuned to the pitch of each sound. Hence most deaf persons hear words best not when spoken in a loud voice, but when spoken slowly and distinctly. A sense of fulness and discomfort within the ear and certain modifications of the hearing are not uncommon during the course of chronic aural catarrh, the commonest modification of the hearing power being paracusis Willisii, or increased hearing power in the midst of noise, as, for example, when the patient is on a moving railroad train. This phenomenon has been ascribed to great rigidity of the ossicles and contraction of the tensor tympani muscle, and it is of sinister import as to the ultimate effects of treatment. The presence of the condi- tion may be demonstrated by placing a large fork of 32 vibra- tions per second on the forehead. If, while the fork is vibrating a watch is heard more distinctly, paracusis willisii is present. Dysacousma or dysesthesia acoustica is a condition in which loud noises or even those of moderate intensity cause painful sensations. When the patient hears his own voice, somewhat altered in character and pitch, as if it came from a distance or through the tissues of his head, the symptom is called autophony Paracusis duplicata and paracusis diplacusis are names given to the phenomenon in which the patient hears sounds as if repeated twice, the second sound seeming somewhat like an echo of the first. Probably in most cases of chronic catarrhal deafness sounds are not only altered in intensity but also in pitch and character as well. It is difficult, however, to observe any subjective alteration in the character or pitch of musical notes, except in the case of musicians who are deaf only in one DISEASES OF THE MIDDLE EAR 407 ear. In such cases not infrequently the note of a tuning-fork will seem to be of a different character and pitch when sounded before the deaf ear from that emitted by the same fork when sounded before the patient's normal ear. When subjective alteration of the character and pitch of sounds is sufficiently manifest to be a source of discomfort to the patient, the name pseudacousma, or false hearing, is applied. Tinnitus, subjective ringing or hissing sounds heard in the ear, is a symptom of aural catarrh rivalling in importance even progressive hardness of hearing. It is sometimes the only symptom of which the patient complains, the fact being that, although he is somewhat deaf, yet his hearing is still sufficiently acute for the ordinary purposes of his life, and occasions no discomfort. Some such patients are actually surprised when tests of their hearing demonstrate that it is defective. This is especially the case when only one ear is diseased. Tinnitus is usually worse at night and it may not be present at all in some cases during the daytime. It is subject to great variations in degree in some cases of aural catarrh, disappearing for months at a time and then reappearing. Usually tinnitus disappears in the later stages of the disease. Involvement of the labyrinth may increase or decrease tinnitus, according as the nerve-fibers are simply irritated or destroyed. The head noises complained of by patients are almost as nu- merous as the individuals affected, but may be divided into three classes-the pulsating, the continuous, and sounds more or less elaborated, like the ringing of bells, music, and words and sen- tences uttered with more or less distinctness-the latter class only being referred to a point outside the head are the result of disease of the ear acting on an easily excitable brain. Some of the cases are at least on the border-line of insanity, and not only hear voices but see visions. Benefit sometimes results from treating the concomitant aural disease. Inflammation of the external auditory canal, foreign bodies, impacted cerumen, and polypi are capable of producing tinni- 408 DISEASES OE THE NOSE, THROAT, AND EAR tus, and, in rare cases, vertigo, nausea, cough, or even epilepti- form convulsions. Sometimes the result of anemia or, more rarely, of an aneu- rysm, pulsating tinnitus ordinarily indicates arterial congestion of the middle ear or of the labyrinth. The differential diagno- sis between the two conditions can be made with a limited amount of accuracy by pressure upon the carotids or on the vertebral arteries at the point where they cross the atlas, because a branch of the carotid supplies the tympanum and a branch of the vertebral supplies the labyrinth. Vertigo is a symptom of chronic otitis media, usually transi- tory in character. In all cases it is probable that aural vertigo is due to some condition within the semicircular canals of the labyrinth: generally it is an alteration of the normal inter- labyrinthine pressure produced by increased tension exerted through the fenestras or by a contracted tensor tympani through a rigid chain of ankylosed ossicles. Only when structural changts have occurred to the tissues within the laby- rinth should the name "Meniere's disease" be given to a condition which otherwise is simply aural vertigo and one of the symptoms of disease of the middle ear. Although the condition of the membrana is not invariably an index of the condition of the tympanum, yet certain infer- ences may be drawn from its appearance that are the more valuable because it is the only visible part of the tympanum. The luster and color of the drum-head may be nearly normal, both at the commencement of chronic otitis media and also at a stage of the disease when the atrophic changes are far ad- vanced. In the latter condition, however, a red reflex from the promontory indicates inflammation of the inner tympanic wall probably involving the labyrinthine capsule-otosclerosis. During the hypertrophic period of catarrh of the middle ear evidences of involvement of the drum-head are usually not lacking. There may be patches of opacity or the whole drum- head may have lost its translucency and appear white, rough, thick, and opaque. The light spot may not occupy its normal DISEASES OE THE MIDDLE EAR 409 position as the result of an indrawing of the drum-head or it may be smaller than normal because of a roughening of its surface, and from the same cause or from local depressions it may divide into two or more maculae. If the drum-head is greatly depressed a light spot sometimes appears over the short process, which projects outward through the tightly drawn tissues like the knuckle of a finger. The handle of the malleus is, under such circumstances, foreshortened, appears shorter than normal, or it may be drawn so far backward as to lie almost horizontal beneath the posterior fold. Spaces abnor- mally white and opaque may be interspersed upon the same membrane with spots abnormally thin and translucent. Fig. 181. Fig. 182. Figs. 181 and 182.-Residua of middle-ear suppuration. Fig. 181.-Transverse section (schematic), showing adhesions of drum-head to promontory. Fig. 182.- Front view, showing old cicatricial center lesions (Spalding). It is always a matter of considerable importance to deter- mine the resiliency and tension of the membrane. This may be effected by observing the movements of the drum through Siegle's pneumatic speculum (Fig. 23). When the air within the canal is rarefied by means of this instrument a drum-head so far indrawn that it rests upon the promontory may be sucked outward until it appears like a balloon, a groove upon its convex surface indicating the position of the malleus handle. Sometimes isolated areas upon the drum-head will exhibit abnormal mobility. Ordinarily such spots are cicatrices formed by the closure of a perforation. This appearance may be produced, however, by localized atrophy. Deep localized depressions are found at spots where adhe- 410 DISEASES OF THE NOSE, THROAT, AND EAR sioris have occurred between the membrane and promontory (Figs. 181, 182), such spots appearing much darker than the surrounding area. Sharply defined deposits of chalk, more especially in the posterior half of the drum-head, are not uncommonly seen (Fig. 171). The patency of the Etistachian tube is tested by the Politzer method of inflation. During the earlier stages of the disease the tubes are usually somewhat obstructed, but during the later stage they are abnormally patulous. A favorable prognosis may be given the patient if after inflation of the tympanum the hearing is greatly improved. Under such circumstances the impairment of hearing is largely due to obstruction of the Eustachian tubes-a condition amenable to treatment. If, however, the tympanum is easily inflated by the Politzer method and there results considerable outward movement of the membrana tympani without much improvement in the hearing, the prospect of speedily improving acuteness of hear- ing is not encouraging. In hyperemic and hypertrophic stages of catarrhal deaf- ness hearing for the voice is usually proportionately worse than for the watch and tuning-fork; in the atrophic form of the disease, however, the reverse is usually the case. If only one ear be affected a vibrating tuning-fork placed on the vertex, forehead, or teeth (Weber's method) is heard best in the affected ear so long as the functions of the auditory nerve and laby- rinth are unimpaired. Before involvement of the receptive apparatus has occurred a vibrating tuning-fork with its handle upon the mastoid will be heard better than when its vibrating tines are held in front of the ear (Rinn£ negative). Great deafness, patulous Eustachian tube, a red reflex though a normal drum head and "Bezold's triad," viz; raised lower tone limit, lengthened bone conduction and negative Rinne indicate otosclerosis. The prognosis is only favorable in cases in which the disease has not progressed beyond the early hypertrophic stage of the disease. Fluid exudates will be absorbed as the result of DISEASES OF THE MIDDLE EAS 411 treatment and simple inflammation of the mucous membrane of the tympanum will disappear. The prognosis is all the more favorable if the disease is the result of pathologic conditions within the nose or nasopharynx, because in such cases, when the nose and throat are restored to a nearly normal condition, chronic aural catarrh of recent origin usually subsides as the result of appropriate local treatment. The progress of the disease can in most instances be delayed, but when new con- nective tissue has formed, it remains, and atrophied parts cannot be regenerated. The prognosis is generally hopeless, so far as improvement of the hearing is concerned, in cases in which the labyrinth is seriously involved. However, this may be said for the comfort of those to whom an unfavorable prog- nosis is given: Chronic middle-ear catarrh is, to a considerable extent, a self-limited disease that progresses irregularly and with greater or less rapidity to a certain degree of deafness, after which the progress is slow. None become completely deaf. Treatment.-An effort should be made to improve the hygienic surroundings of the patient and to so improve his general health as to render him less liable to contract colds. The nose and throat, if necessary, should receive appropriate treatment. Hypertrophies, ecchondroses, and exostoses of the nasal chambers and adenoid vegetations in the pharyngeal vault should be removed and cicatricial bands broken down; hypertrophied faucial tonsils should be reduced to their normal dimensions. While the immediate effect of any measure to secure free nasal respiration may not be apparent in improved hearing, the freedom from frequent stenosis of the nares from colds and consequent irritation of the middle ear will, after a month or two, scarcely fail to attract the patient's attention. Triweekly or even daily inflation of the Eustachian tubes is of great importance. For this purpose Politzer's method, when possible, should be employed in hypertrophic cases. In atrophic cases, however, the irritation produced by the intro- duction of the Eustachian catheter is somtimes of marked 412 DISEASES OF THE NOSE, THROAT, AND EAR benefit. Either simple air or air saturated with the vapor of chloroform, iodin, menthol, or turpentine may be used for producing the inflation (Formulas 80 to 83). In cases where the labyrinth is involved, Politzer's method of inflation should be used with extreme gentleness if at all. Ordinarily in atrophic cases the Eustachian tubes are widely dilated, and the violent use of Politzer's bag causes a most un- pleasant sensation to the patient and an immediate decrease in the hearing power, which gradually grows worse from repetition of the treatment. In cases of otosclerosis phosphorus in gr. doses three times a day for six months of the year is sometimes beneficial. Politzer advises a course of potassium iodid. Many cases not too far advanced are greatly benefited by a spray of menthol and camphor in fluid albolene (Formula 127), thrown into the middle ear by means of the Eustachian catheter and atomizer. After introducing the catheter and applying the auscultation-tube the patulency of the Eustachian tube is tested by means of Politzer's bag (Fig. 149). The nozzle of an atomizer is then inserted within the proximal extremity of the catheter. In cases where the Eustachian tube is widely dilated the spray from the atomizer will be heard to enter the tympanum; but in most instances it enters the Eustachian tube for but a short distance, except during the act of swallowing by the patient. After a time a certain amount of oil condenses in the catheter and Eustachian tube. This should be blown as far up the tube as possible by means of Politzer's bag. For the same purpose Politzer advises 5 to 8 drops of a solu- tion of sodium bicarbonate (10 gr. to 1 dram of water), to which has been added 8 drops of glycerin; 5 or 6 drops of a 2 per cent, solution of pilocarpin has been employed with advan- tage. Perspiration and salivation occur while the patient is still in the office and the treatment is unadvisable for those with weak hearts. Thiosinamin, 6 to 10 gr., in divided doses per day, or 12 to DISEASES OF THE MIDDLE EAR 413 18 min. of a io per cent, solution three times a week, is said to promote absorption of deposits. Local treatment should not be continued after improvement in the acuteness of hearing ceases. All possible improvement can be secured usually in from three to six weeks by local treatment every other day. However, if symptoms of relapse appear after a time, renewed local treatment will be necessary. Stricture of the Eustachian tube may be dilated by care- fully passing a Eustachian bougie through the stricture, but the use of this instrument requires the utmost care to avoid a disastrous or even fatal result from emphysema as the result of tearing the tubal mucous membrane. The diagnosis of stricture of the tube is made by means of the catheter and auscultation-tube. Air is not heard to enter the tympanum. This may be due to simple swelling of the mucous membrane, transient in character, which can be made to yield by blowing a drop or two of a 4 per cent, cocain solution from the catheter into the tube, followed in a few moments by an oily spray of adrenalin (1 :iooo) through the catheter. If after a few moments air is heard to enter the middle ear through the catheter, the Eustachian tube may be sprayed with menthol-camphor-albolene in the manner previously described. If, however, these measures fail to secure the entrance of air into the middle ear, employment of the Eustachian bougie is a justifiable procedure. As long as no stricture is encountered the bougie can be passed somewhat readily from the catheter along the Eustachian tube. If resistance is felt, it may be due to the normal narrowing of the tube at the isthmus. The bougie should be marked in millimeters in such a manner that it is possible, by referring to these markings, to know the exact position of the distal end of the bougie, and when it has entered the isthmus or junction of the cartilaginous and bony portions of the tube. It is not desirable to push the bougie much be- yond this portion of the tube. If a stricture is encountered a resistance will be felt to the 414 DISEASES OF THE NOSE, THROAT, AND EAR onward passage of the bougie, which usually can be overcome by gentle pressure for a few moments. After the bougie has passed beyond the stricture it should be allowed to remain in position for a few minutes and then withdrawn. When it is impossible to pass a bougie of hard rubber or whalebone, an attempt may be made to destroy the stricture by electrolysis. Duel has devised gold bougies of three sizes for this purpose, one of which is passed through a rubber-covered catheter into the tube until the stricture is encountered. The sponge from the positive pole of the battery is applied to the patient's neck and the negative pole is connected with a bougie. The current is then gently turned on to a strength not exceeding 3 to 5 milliamperes. The bougie is held firmly in contact with the stricture and after a moment is felt to pass through it. The treatment causes no pain and may be repeated at inter- vals of once a week. It is safer not to attempt to inflate the middle ear immediately after the passage of a bougie. The patient, however, may return the next day to have his ears inflated. The bougie may be passed into the Eustachian tube after the passage has been oiled with the spray from an atomizer containing albolene, or a few drops of a 50 per cent, solution of argyrol may be dropped into the catheter before passing a hard- rubber bougie through it into the tube. Massage of the Middle Ear.-Next in importance to inflation of the middle ear is systemic massage by means of Siegle's pneu- matic speculum (Fig. 23) or some other massage instrument by means of which the air within the auditory canal can alternately be condensed and rarefied, and motion be thus imparted to the membrana tympani and ossicles. This pro- cedure is almost invariably followed by an amelioration of tinnitus if this be present, and it probably constitutes the most satisfactory treatment for this annoying symptom, although freezing the tissues over the mastoid process by means of the spray from a tube of ethyl chlorid and exhausting the air within DISEASES OF THE MIDDLE EAR 415 the auditory canal by a plug of oiled absorbent cotton some- times yield good results. Systematic massage of the middle ear by means of the patient's finger-tips is of the greatest value, for while it is some- what dangerous to instruct an individual to inflate his middle ear by Valsalva's method, as its frequent use is liable to be followed by atrophy of the drum-head and increased deafness, automassage with the finger-tips is entirely harmless and may be used for the relief of tinnitus whenever it becomes annoying. The forefinger should be slightly moistened and slipped into the meatus with the nail posterior. With rapid piston-like movements of the finger-tip inward and outward a patient can easily exercise alternations of pressure and rarefaction of the air within the auditory canal, and hence massage the intratympanum almost as thoroughly as if a pneumatic speculum were used. He may be instructed to employ the method several times a day with increasing relief of tinnitus in many instances and, generally, improvement of the acute- ness of hearing. It is seldom that the method fails to afford at least temporary relief from the feeling of fulness or pressure within the ear. Phonomassage, by means of sounds conveyed to the ear through rubber tubes from various musical instruments or similar contrivances, has been employed in the treatment of catarrhal deafness and tinnitus. If the ears of an individual with catarrhal deafness be subjected for a length of time to musical tones of about the same pitch as the tinnitus from which he suffers, the subjective noiseswill either entirely dis- appear or be greatly alleviated, probably as the result of fatigue of the portion of the internal ear adapted to the perception of sounds of that pitch. This method of treat- ment has been largely abandoned in favor of more rational methods. Pneumomassage with electromagnetic and other machines, capable of producing rapid alternate rarefaction and condensa- tion of the air in the auditory canal, is undoubtedly of benefit 416 DISEASES OF THE NOSE, THROAT, AND EAR in a large proportion of chronic middle-ear catarrhs, but is probably in no way superior to massage with the pneumatic speculum or the tip of the forefinger. The same remark also applies to direct massage of the chain of ossicles by means of Lucca's pressure probe, which is a spring probe, the cup-shaped end of which fits over the short process of the malleus to pre- vent slipping; and also to the so-called "internal massage," where short, sharp puffs of compressed air from an air-receiver are, by means of an "automatic cut-off" (Fig. 30) rapidly worked with the tip of the thumb, thrown through a catheter into the Eustachian tube. The wedging of a little ball of absorbent cotton into the space above the short process of the malleus where its weight and pressure serve constantly to push outward the malleus handle and the long process of the incus, thus diminishing pressure on the stapes, in a certain number of cases will afford efficient aid in the treatment of tinnitus and hardness of hearing. The little mass of cotton should be moistened with a suitable anti- septic solution, so that it can be molded to the parts when inserted above the malleus handle, and may be worn for several weeks at a time with benefit in certain cases. It is not readily dislodged from its position by massage either with the pneu- matic speculum or the finger-tip, and sometimes gives imme- diate and ultimately permanent relief from tinnitus. Tension of the transmitting apparatus of the middle ear may also be decreased by operative procedures, such as repeated paracentesis of the drum-head, tenotomy of the tensor tympani and stapedius, or removal of the membrana tympani and one or more of the ossicles. Tinnitus is not always the result of diseases of the ear, but rather is a reflex phenomenon due to the irritation of some correlated region-the nose, teeth, or, more frequently, the digestive tract. Just as acute dyspepsia is ordinarily accom- panied by vertigo, so the more chronic ailments of the digestive tract sometimes occasion a tinnitus the cause of which is little suspected. The manner in which disease of the digestive tract, DISEASES OF THE MIDDLE EAR 417 teeth, or nose produces tinnitus is through the nervous connec- tion, more or less direct, of those organs with the inferior cervical sympathetic ganglion, which supplies the nervi vasorum to the occipital artery and its branch, the internal auricular. Irritation of the inferior cervical sympathetic ganglion would cause tinnitus as the result of dilation of the arterioles of the cochlea, which, at first pulsating, would afterward become constant in character as the result of trophic changes resulting from increased blood-supply. Quinin, the salicylates, and certain other drugs are capable of producing tinnitus, either as the result of aural hyperemia or by their toxic action upon the internal ear. There is also reason to suppose that in lithemia the products of indigestion exert a similar action in the production of tinnitus. It is, therefore, in cases where dyspepsia and lithemia have done their share in the production of tinnitus, that acids, including hydrobromic acid, are especially useful in controlling this annoying symptom. Proper regulation of the diet and regular exercise in the open air and sunlight will, in cases where there is neither disease of the ear, nose, or teeth to account for tinnitus, generally result in a disappearance of the head noises. The faint puslating tinnitus due to anemia is diminished by the patient's lying down, and in many instances can be per- manently cured by hygienic measures and suitable tonics, among which the well-known pil. sumbul comp, is especially useful. Pulsating tinnitus due to congestion, on the other hand, may be alleviated by the bromids, of which, for the reason stated above, dilute hydrobromic acid, in doses of from 15 to 60 drops three times a day, is probably the best. The earlier stage of chronic catarrh of the middle ear is ordi- narily accompanied by tinnitus, generally constant in character. Later on, as deafness becomes profound, tinnitus often dis- appears as the result of diminished sensibility of the internal ear. Tinnitus due to middle-ear catarrh is sometimes alle- viated by large doses of the bromids; but better results can be obtained in a limited number of cases by the patient taking 418 DISEASES OF THE NOSE, THROAT, AND EAR after meals, for a few weeks, a pill containing | gr. of nitrate of silver, | gr. of extract of hyoscyamus, and gr. of strychnin. Otitis Media Suppurativa Acuta.-Acute purulent inflam- mation of the middle ear is an acute purulent inflammation of the mucous membrane of the tympanum, and usually also of that of the Eustachian tube and mastoid cells. Pathology.-The tympanic mucous membrane is of a bright red color, much swollen, and devoid of its epithelium. There is cellular and serous infiltration of its connective-tissue layer and much exudation of mucopus or pus from its surface. Per- foration of the membrana tympani occurs in the majority of cases, the pus being then discharged through the perforation into the auditory meatus; occasionally the discharge is tinged with blood. Etiology.-Generally the disease is the result of a cold or of traumatism, or it may occur as a complication during diph- theria, scarlatina, small-pox, measles, typhoid fever, syphilis, or tuberculosis. Purulent inflammation of the middle ear is very common in children. Carious teeth and nasopharyngeal disease are predisposing causes of the affection. Suppuration presupposes bacterial infection, which probably takes place in most instances by way of the pharynx and Eustachian tube. It is a general rule that the infection at first at least is monobac- terial, but that after the membrane is ruptured, polybacterial infection commonly occurs from the canal. Efforts should, of course, be directed to prevent if possible this mixed infection. The microorganisms most commonly found in otorrheal pus are streptococcus pyogenes, pneumococcus, staphylcoccus aureus and albus, Friedlander's bacillus, typhoid, and tu- bercle bacilli. Of the monobacterial infections, that of the streptococcus is most likely to run a severe course, often ending in severe mastoid complications. Symptoms.-An attack is ushered in by pain in the ear, shooting over the side of the head. Sometimes the pain originates in a diseased tooth and extends to the ear. Chilly sensations and fever are sometimes present, the temperature DISEASES OF THE MIDDLE EAR 419 reaching as high as 1020 or 1030 F. The ear feels full and there are tinnitus and deafness, the pressure of confined pus upon the secondary membrane sometimes interfering with the functions of the labyrinth. When perforation takes place there occurs a rapid alleviation of the pain and tinnitus. The appearance of the drum-head is that of acute myringitis. At the end of a few hours to several days or even weeks from the beginning of the attack a bulging at some point upon the drum-head indicates the position where the pus will burrow its way through the membrana. When, however, the attic and mastoid antrum contain pus which cannot readily drain into the atrium because of swelling of the mucous membrane about the ossicles, this pus will sometimes burrow underneath the skin of the auditory canal and find an exit either at some point within the canal or behind the auricle. Those cases in which no perforation occurs run a tedious course and some permanent impairment of the hearing usually ensues. The duration of the disease from the occurrence of a perforation to its closure is very variable. In cases where the perforation occurs early, it may remain open only for a few days. Three or four weeks are ordinarily required for the closure of a small perforation. If the perforation is large it will probably remain open long after suppuration has ceased, to finally close by cicatricial material destitute of all fibers of the membrana propria, and will bulge inward and outward with the varying intratympanic pressure. Extensive destruction of the structures of the middle ear sometimes occurs during acute otitis media. This is especially apt to take place when the disease appears as a complication of scarlatina, variola, or diphtheria. The whole of the drum- membrane and all of the ossicles may come away within a few days from the onset of the middle-ear disease as an enormous slough. In other cases, ulceration, starting from the perfora- tion, proceeds more slowly, but it accomplishes equally disastrous results. Inflammation of the mastoid is occasion- ally a serious complication of acute otitis media, and the laby- 420 DISEASES OF THE NOSE, THROAT, AND EAR rinth sometimes participates in the purulent inflammation of the tympanic cavity, the ultimate result in such cases being intracranial complications, often fatal, unless the labyrinth is opened and efficient drainage secured. Infants affected by acute suppuration cry constantly, turning their heads restlessly from side to side, placing the hand frequently upon the affected ear. High temperature, reaching 103° or 104° F., is usually present and convulsions sometimes occur. The infant sleeps only when completely exhausted or under the influence of opiates. Upon inspection the drum-head is often found enormously swollen, projecting into the canal like a polypus, for which it has been mistaken. Sleeplessness, high temperature, and restlessness quickly disappear after evacuation of the pus. The prognosis of acute purulent inflammation of the middle ear, when it occurs in an otherwise healthy individual, is usually favorable, but the severity of the attack depends largely on the variety of bacteria causing the infection and their virulence. However, the disease frequently assumes the chronic form, and in tuberculous individuals this is the usual outcome of the affection. Treatment.-In the early stages of the disease, leeches, hot applications, and the other measures already specified as useful for the relief of pain in catarrhal inflammation of the middle ear. Paracentesis of the membrane should be done as soon as bulging occurs. The cut should be 2 or 3 millimeters long and should be made through the point at which the bulging occurs or at the so-called point of election in the posterior quadrant of the membrana tympani, midway between the malleus handle and the periphery (see p. 398). When there is considerable swelling of the upper posterior part of the auditory canal, indicating the presence of pus beneath the skin of this region, the thrust should be through Shrapnell's membrane, and the knife be so with- drawn that its point will cut through the swollen tissues at the upper posterior portion of the canal to the bone, in order to secure free drainage. DISEASES OF THE MIDDLE EAR 421 After incision of the drum-membrane or when rupture has occurred spontaneously the major part of the pus within the auditory canal should daily be removed by means of absorbent cotton wrapped about the end of a probe, and the pus within the tympanum expelled through the opening in the drum-head by the Politzer method of inflation and suction with Siegle's pneumatic speculum. After this has been accomplished the auditory canal should be cleansed thoroughly by means of a cotton-tipped probe wet with a 15-volume solution of hydrogen peroxid, the parts thoroughly dried, and covered with powdered boric acid by means of a powder-blower. Fig. 183.-Blake's polypus snare. If exuberant granulations sufficiently large to obstruct free drainage from the tympanum occur, they should be removed by means of a snare (Fig. 183), by Hartmann's forceps (Fig. 169), or by touching them with chromic acid fused on the end of a probe. Considerable caution is required in the use of chromic acid. The granulations or small polypi should be first dried thoroughly by means of absorbent cotton, in order to prevent the acid dissolving and flowing over adjacent struc- tures. No more of the acid should be applied than is neces- sary to accomplish the desired result, and any excess remaining within the canal should be neutralized by syringing with a warm alkaline solution. Small polypi and exuberant granulations are most apt to occur and obstruct drainage when the pus has found its way through an opening in Shrapnell's membrane at a point on the upper and posterior part of the auditory canal. Much improvement often results from injecting a 5 per cent, solution of argyrol into the tympanum through the perforation every 422 DISEASES OF THE NOSE, THROAT, ANDEAR second or third day. The author has seen the discharge quickly cease in a number of cases as the result of one or more such intratympanic injections. As the solution frequently remains for several hours within the tympanum, its strength should not be over 5 per cent., as more concentrated solutions are capable of increasing the inflammation; nor should the injections be repeated oftener than once in two or three days. Brilliant results have been obtained by vaccine therapy. Otitis Media Suppurativa Chronica.-Etiology.-'Chronic purulent inflammation of the middle ear is generally caused by neglect or improper treatment of acute purulent disease of the middle ear and the failure to secure ade- quate drainage. Adenoids, nasopharyn- geal disease, and malnutrition prevent sometimes a prompt secession of an otor- rhea. The affection may, however, de- velop primarily as the result of syphilis or tuberculosis. Numerous cases are the re- sult of scarlatina. Symptoms.-There is a mucopurulent or purulent discharge, sometimes tinged with blood. The acute- ness of hearing varies according to the amount of destruction of the structures of the middle ear or to the presence of polypi or semi-inspissated secretions blocking the canal or in- terfering with the functions of the ossicles. In some instances the hearing is nearly normal, while in others deafness is nearly absolute. Tinnitus may or may not be present. The presence of a discharge in the auditory canal from the middle ear presupposes the presence of a perforation of the drum-head. The perforation, on the one hand, may be so mi- nute as to escape observation by otoscopy, its presence being only revealed by a "perforation whistle" during inflation of the ear either by Politzer's or Valsalva's method. On the other hand, the destruction of the drum-head may be so exten- sive as to expose the cavity of the tympanum to view and reveal Fig. 184.-Residua of middle-ear suppura- tion. Nearly total loss of the drum-head. Handle of hammer resting on mucosa of promontory (Spalding). DISEASES OF THE MIDDLE EAR 423 all of the structures of the inner wall (Fig. 184). In some cases the remains of the drum-head may be represented only by a narrow ring; in other cases the ossicles may have also disap- peared, either from ulceration and sloughing of their ligaments or by necrosis of the bones themselves. Necrosis of some por- tions of the tympanic walls may also exist. To a considerable extent the position and size of the perforation will indicate the position and extent of the necrotic process (Fig. 185). The appearance of the tympanic mucous membrane varies somewhat. In one class of cases it is simply red and swollen, while in another class it appears granular and polypi may be present, perhaps covering the orifice of a sinus leading to exposed bone. Fig. 185.-1-5, Simple suppurations of the drum-cavity and the Eustachian tube; 6, 8, caries of the incus; 7, caries of the head of the malleus; 9, attic suppura- tion with possible caries of both malleus and incus; 10, 11, caries of the head of the malleus; 12, caries of the incus and suppuration of the antrum, and, possibly, associated cholesteatoma (Leutert). Usually there is a destruction of the ciliated epithelium and a thickening of the mucous membrane from infiltration of round cells with a dilatation and new formation of blood-ves- sels. Fungiform excrescences cover the thickened mucous membrane, which contains small cysts lined with cylindric epithelium containing epithelial cells, leukocytes, and detritus. The bacteria of the discharges are staphylococci and sapro- phytes. Prognosis.-Untreated, some cases, after discharging for a year or two, finally cease discharging, the perforation in the membrane closes, and the hearing, while not entirely normal, 424 DISEASES OF THE NOSE, THROAT, AND EAR becomes fairly good. This result is most likely to occur in cases with perforations similar to those shown in Fig. 185, 1-3. In other cases, where there is a large destruction of the mem- brane, the discharge ceases for a time only to recur at intervals. In this class of cases there is only occasionally an apparent discharge, which for long intervals never appears externally. A scanty discharge, mixed with dust and other materials, dries at the fundus of the canal until it becomes a source of irritation, when, perhaps partly as the result of a cold, an abundant otor- rhea is set up which sweeps away the old inspissated accumu- lations. Gradually this abundant otorrhea subsides until for another period no discharge appears externally . This is not an infrequent termination in cases where there is a large destruc- tion of the membrane, as in Figs. 184 and 185, 4. In cases of this character occasional careful cleansing of the ear and in the case of a recurrent discharge one or two applications at inter- vals of a day of a 10 per cent, solution of argyrol will maintain the ear in a fairly satisfactory condition. Often the hearing is fairly good. The mucous membrane of the inner wall of the tympanum rarely epidermatizes and becomes entirely dry. Occasionally, where there is as nearly a complete destruction of the drum-head as in Fig. 184, the opening will become closed by a huge thin cicatrice, which, ballooning inward and outward with every change in intratympanic pressure, is rather a hin- drance than an aid to hearing, but serves to exclude cold dust, and other irritants. Cases where there is a small opening in or just below Shrap- nell's membrane leading to carious bone or an accumulation of filth (cholesteatomatous material) discharge indefinitely a scanty, watery fluid which sometimes dries upon the tym- panum, forming an accurate cast of that structure when removed. Such so-called "attic cases" (Fig. 185, 6-12) are always a source of greater danger in the production of mas- toid and intracranial complications than other forms of chronic otorrhea, although many attic cases reach a ripe old age with no more serious discomfort than partial deafness and a scanty DISEASES OF THE MIDDLE EAR 425 discharge. Apparently there are no statistics bearing on the subject. Treatment.-'Conditions preventing the cessation of a chronic discharge from the middle ear are polypi; a pulpy or granular condition of the mucous membrane; insufficient drainage, because of a small perforation or one unsuitably situated; necrosis of one or more of the ossicles or of the tympanic walls; cholesteatoma. In chronic otorrhea, the result of tuberculous infection, it is very difficult to bring about a cure of the suppuration even by the most radical operations. However, such cases usually die from the concomitant phthisis before the tuberculosis of the ear has progressed sufficiently to render a radical mastoid opera- tion justifiable. The treatment of uncomplicated cases consists in daily thor- ough cleansing of the interior of the drum, already described as necessary in the treatment of acute purulent inflammation of the middle ear. If the perforation through the membrana is not sufficiently large to permit of this being readily accom- plished, it should be enlarged or a counteropening made, and the interior of the drum syringed by means of Blake's middle- ear canula (Fig. 28, 2, 3, or 4). When, with large perforation, pus is seen to flow downward from the attic into the tympanum, the nozzle of the curved canula should be introduced into the attic through the perforation so as to thoroughly cleanse this cavity. After the cavity has been thoroughly cleansed it should be dried carefully by means of absorbent cotton wrapped about a probe and the parts covered by powdered boric acid. The suc- cess of the treatment depends upon the thoroughness with which the cleansing is accomplished at each daily visit of the patient. If the tympanic mucous membrane is granular the routine treatment outlined above will not be sufficient to secure a speedy cessation of the discharge until the granulations are destroyed. Alcohol has the power to cause a shrinking of the 426 DISEASES OF THE NOSE, THROAT, AND EAR granulations because of its dehydrating qualities, and absolute alcohol may be applied by means of a cotton-tipped probe at each daily visit of the patient after the ear has been thoroughly cleansed. The application of absolute alcohol causes some pain, and it may augment the discharge for a few days. Al- cohol (95 per cent.) may also be prescribed for the patient's use at home, 20 drops or more being instilled into the ear sev- eral times a day, care being exercised that the patient's head is held in such a position each time that the alcohol dropped into the ear will be sure to reach the cavity of the tympanum. For the first few days it may be necessary to dilute the alcohol somewhat because of pain. However, it should be remembered that the dehydrating properties of 50 per cent, alcohol are practically nothing. A good method of prescribing alcohol is to instruct the patient to mix in a 2-dram vial equal parts of alcohol and water for the first day's use. If this mixture causes only momentary pain, to use the next day 2 parts of alcohol and 1 part water, and so on from day to day until 95 per cent, alcohol can be used without great distress. When the dis- charges are fetid, compound tincture of benzoin should be sub- stituted for alcohol until the fetor has disappeared. Before dropping alcohol into his ear the patient or one of his friends should be instructed to remove all accumulations of pus from the ear in the following manner: The auditory canal is first straightened by drawing the auricle upward, backward, and outward. A cotton-tipped wooden tooth-pick is then in- serted gently to the bottom of the canal, and then withdrawn and discarded. The procedure is repeated until cotton fails to absorb and bring away any discharge. In case of a child, where the patient or nurse cleanses the ear, the child should be placed in front of a window before the canal is straightened, so that the light may be directed into the ear and a view of the fundus of the canal obtained. Cleansing the ear by some method is absolutely necessary before dropping alcohol into it, as otherwise the alcohol will be diluted and the tissues protected by a layer of pus so thick in DISEASES OF THE MIDDLE EAR 427 most instances that the alcohol will never reach the diseased parts. If it is deemed wise to order the patient to cleanse his ears with a syringe, he should be carefully instructed as to the proper method (p. 377), and also how to dry the ear. It is well at the first treatment of the patient with chronic otorrhea to begin by a thorough cleansing of the canal and tym- panum by syringing with sublimate solution. The writer has very serious doubts as to the value of home syringing, either by the patient or his friends. A girl about twelve years of age was brought to the Medico-Chirurgical Ear Dispensary some years ago almost totally deaf and with double facial paralysis as the result of scarlet fever. The odor from the child's ears was indescribably fetid. The mother stated that she had syringed the child's ears every day for the past six months. From the child's left ear there was quickly syringed a fetid mass of pus, the malleus, the incus, and part of the an- nulus tympanicus; from the right ear, fetid pus and the malleus. In six months of daily syringing the parent had evidently failed to remove any of the accumulation at the fundus of the auditory canal, but had simply syringed away some of its superficial portion. The case illustrates the value of home syringing of the ear as ordinarily performed. For the patient's use the syringe made of a single piece of soft rubber (Fig. 27) is probably the safest and most effective instrument. All things considered, a warm saturated solution of boric acid is the most convenient detergent ear-wash for home use. The patient should be instructed to place 1 or 2 tea- spoonfuls of the crystals in a wide-mouthed bottle holding about 4 ounces, fill the bottle with warm water, syringe the ear, and afterward cork the bottle. At each subsequent syringing a sufficient amount of boiling water from the teakettle is added to bring the saturated solution of boric acid up to a temperature suitable for syringing the ear. As the crystals of boric acid are dissolved, more should be added from time to time, in order to 428 DISEASES OF THE NOSE, THROAT, AND EAR maintain a saturated solution of boric acid conveniently ready for use. However, a certain number of chronic otorrheas, especially those with large perforations, do better when syringed with bi- chlorid of mercury (1:5000 or 1:10,000) than with boric acid solution, and there is a very large proportion of such cases that experience little discomfort as long as they syringe their ears once a week or even at longer intervals with the bichlorid solu- tion. In such cases astringents are much less effective than antiseptic solutions. However, most cases of acute and chronic suppuration, under ordinary circumstances of ready access to the aurist's office or the dispensary, do better without home syringing; and when alcohol or other drops are prescribed for home use, they are best dropped into the ear after a dry cleans- ing with absorbent cotton. In a certain proportion of cases of chronic otorrhea the discharge continues because the tympanum is constantly rein- fected from the Eustachian tube. Yankauer has devised a sec of three tubal curettes by means of which the mucous membrane can be stripped from the tube at the isthmus thus securing its complete closure. The tube is anesthetized with cocain and adrenalin and a curette of suitable size to fit somewhat snugly is passed through the tympanum into the tube as far as the isthmus and the mucous membrane stripped from the bone backward toward the atrium. The operation is followed by little reaction and in most instances results in at least dimin- ution of the discharge. Aural Polypi.-In some instances where a large perforation exposes swollen or granular mucous membrane upon the promontory, rapid cessation of a chronic discharge will be brought about by lightly touching the parts once or twice a week with a 25 per cent, solution of trichloracetic acid in conjunction with the treatment already advised for chronic suppuration. When the granulations are isolated they may be scraped away with a sharp curette or be removed with the for- ceps. Large granulations and polypi are best removed with a DISEASES OF THE MIDDLE EAR 429 snare. It should be borne in mind, when removing a polypus with a snare, that, although the polypus is absolutely devoid of sensation, the wall of the auditory canal, as the result of long maceration in pus, is often exquisitely sensitive, and in guiding the wire loop of the snare over the polypus it is advis- able to avoid, as far as possible, touching the auditory canal. If the polypus is large, an effort should be made to locate its pedicle by means of a probe. The wire loop of the snare should then be worked gradually inward over its surface until, if possible, the pedicle of the polypus is encircled. The wire loop should then be tightened to cut through the polypus. If the operator has not succeeded at the first attempt in removing the whole of the polypus, this maneuver may be repeated until the desired result has been accomplished. Bleeding may be checked at any stage of the operation by means of a tampon of absorbent cotton saturated with a i: 1000 solution of adren- alin, and by afterward cauterizing the stump of the polypus with nitrate of silver fused on the end of a probe. Wilde, who was probably the first to design a snare for the removal of polypi, generally used his snare, not to cut through the polypus, but to firmly grasp it and drag it from its attach- ment. The author has frequently used forceps for the same purpose; but it should be remembered that when latent diffuse labyrinthitis is present, any operation in the middle ear may render the latent disease active with resulting septic meningitis and death (p. 524). Pathology.-Aural polypi (Fig. 186) may be divided into four classes. About 50 per cent, of all aural polypi are granu- lation tumors, having the same structure as ordinary granula- tions, but covered by either squamous or columnar epithelium; 90 per cent, of aural polypi, other than granulation tumors, are mucous papillomata. They are extremely vascular and some- times bleed at the slightest touch. Their structure consists of capillary loops surrounded by a stroma of somewhat imper- fectly developed connective tissue containing cuboidal epithe- lial cells. They are covered by a pavement-epithelial layer of 430 DISEASES OF THE NOSE, THROAT, AND EAR varying thickness. Fibroid polypi (fibromata), which are somewhat rare, are usually found as large, dense, pale polypi developed from the periosteal or deeper layer of the tympanic mucous membrane. Fibrous polypi are also covered by several layers of pavement epithelium. Myxomatous polypi are very rarely found in the human ear. Aural polypi are not malignant, the treatment outlined above being sufficient to prevent a recurrence of. the growth. It should be borne in mind, however, that epitheliomata, sarcomata, and gummata sometimes occur in the middle ear and present the appearance of polypi, but such growths are rare in this situation. Symptoms. - Long-continued dis- charge, often streaked with blood, is usually the only subjective symptom. Certain reflex symptoms, the result of peripheral irritation caused by the presence of an aural polypus, have been described as occurring in rare cases. Most aural polypi have their origin at the posterior and upper part of the tympanum. They may, however, arise from any part of the tympanic cavity or even from the dermic layer of the drum-head. Sometimes they originate at the mouth of a sinus extending through the skin of the auditory canal to carious or necrosed bone. Caries and Necrosis.-Caries or necrosis of the temporal bone may occur during the course of long-continued suppura- tion of the middle ear or as the result of syphilis, tuberculosis, trauma, osteomyelitis, and diabetes. The upper and posterior part of the auditory canal, the mastoid, and the tegmen of the tympanum and antrum are the portions most usually first involved. Caries most frequently attacks the cancellous bone; necrosis, the compact bone. Symptoms- Circumscribed caries may exist within the tym- Fig. 186.-Polypi (Steudener). DISEASES OF THE MIDDLE EAR 431 panum during chronic purulent disease of the middle ear and present no symptoms other than that exposed and roughened bone can be detected by means of a probe. Sudden paralysis of the facial nerve may occur as the result of necrosis of the inner wall of the tympanum involving the facial canal; however, a considerable portion of the facial canal may be opened and the nerve be bathed in pus for some time before symptoms of Bell's palsy occur. The labyrinth may be opened, generally through the horizontal semicircular canal, and a circumscribed or even a diffuse labyrinthitis with or without ultimate infection of the intracranial contents result. The tegmen tympani and tegmen mastoideum not infrequently are destroyed as the result of necrosis or caries. Under such circumstances there com- monly occurs a local pachymeningitis, which prevents the spreading of the disease upon the dura mater. Pus may find its way into the nasopharynx or beneath the tissues about the auricle. The necrosed bone in the more chronic cases is usually imbedded in exuberant granulations, through which a probe detects, by the sensation of a rough surface, necrosed bone. If a cotton-tipped probe is used the rough surface catches in the fibers of cotton, producing a characteristic sensation. Treatment.-The mere presence of localized spots of necrosis or caries upon one of the larger ossicles is hardly a sufficient reason for its removal. Perfect cleanliness and good drainage is ordinarily sufficient to bring about a cure of the condition. The rubbing of the parts with a cotton-tipped Allen probe that has been dipped in hydrogen peroxid, and proper daily intra- tympanic syringing will have a stimulating action upon the parts and aid the proliferation of epithelium over the dis- eased area. If these measures fail, the malleus and incus should be excised to permit freer access to the attic and better drain- age, but in cases of suppuration of the antrum (Fig. 187) it is probable that a radical mastoid operation will be required to bring about a cessation of the discharge. If a sequestrum has formed, it should be removed with forceps. Politzer's forceps 432 DISEASES OE THE NOSE, THROAT, AND EAR (Fig. 170) are usually strong enough for this purpose, but Sexton's or Hartmann's (Fig. 169) foreign-body forceps can often be used to better advantage. If it be found impossible to remove the sequestrum through the auditory canal because of the granulations and polypi that obstruct the canal, they should be removed by means of a snare; after a few days, in some instances, the sequestrum will have been pushed outward by the granulations behind it into a position where it can readily be grasped by forceps and removed. In cases of caries or where the necrotic process has not pro- gressed to the formation of a sequestrum, the diseased bone should be scraped away by means of a sharp curet and the parts covered with powdered boric acid. When caries or necrosis affects the promontory, only the most superficial curetting is justifiable; but the parts should be kept scrupulously clean and as dry as possible by means of frequent insufflations of powdered boric acid. Cases where necrosed bone can be felt in a portion of the tympanum inaccessible to the curette are best treated by instillations twice a day of enzymol, a preparation containing pepsin. By this means the middle ear is, as it were, converted into a stomach capable of digesting the dead bone. Pepsin, of course, has no effect on living tissue. The patient should then lie down with the diseased ear uppermost and fill the canal full of enzymol. The excess of fluid is allowed to escape when the patient assumes the erect posture. Several hours are required for the pepsin to produce its effect as a digestant, and the presence of granulations may prevent its coming into con- tact wit dead bone. It is well, therefore, after enzymol has been used for a few days to employ instillations of alcohol for a day or two. However, when the ear is deaf and there is a fistula into the labyrinth, it will be safer to do a radical mastoid operation to prevent the possible infection of the meninges. The prognosis, of course, varies according to the part of the tympanum attacked by necrosis. In individuals otherwise healthy the prospects of a favorable result are encouraging, even when a large portion of the temporal bone is involved by DISEASES OF THE MIDDLE EAR 433 the disease. In tuberculous individuals, however, the disease sometimes progresses toward a fatal termination notwith- standing all efforts to prevent it. The prognosis is doubtful where there are symptoms of intracranial imvolvement, pye- mia, or metastatic abscess. Fatal hemorrhage may occur from the carotid when its bony canal is involved. The rup- ture of the vessel usually occurs at " Hassler's site of predilec- tion," that is, at the knee of the carotid in the bony canal, where it abruptly changes its course from the vertical to the horizontal. Aural cholesteatoma is an accumulation within the auditory canal and tympanum of a mass consisting of epithelial scales, cholesterin crystals, and inspissated pus, derived by desquama- tive inflammation from the lining membrane of the tympanum or mastoid cells. The presence of cholesteatomatous masses usually causes impaired hearing and sometimes tinnitus, nausea, and dizziness. The bony and soft structures become absorbed as the result of the pressure caused by the accumulation, so that choleste- atomatous accumulations sometimes occupy large cavities. Small collections of cholesteatomatous material are common at the upper and posterior portion of the auditory canal in cases in which perforation of Shrapnell's membrane has occurred. The mass often extends into the attic of the tym- panum, sometimes into the mastoid antrum. Cholesteatoma are usually not easily detected at the first glance. Sometimes a small mass projecting into the meatus will be the only evi- dence of the presence of a cholesteatoma of considerable size. If, however, the small mass be removed, other masses will be found, until in some instances a cavity of considerable size will have been emptied of its contents. Etiology.-When the membrana tympani is perforated as the result of disease or operative interference the opening in the drum-head generally promptly closes. If, however, a large portion of the drum-head is destroyed as the result of long- continued suppuration, the epidermis of the canal proliferates 434 DISEASES OE THE NOSE, THROAT, AND EAR over the margins of the perforation and prevents its being filled by granulations; so that the perforation tends to become per- manent. Furthermore, under certain conditions the epidermis of the canal proliferates over the walls of the cavities of the middle ear, and a greater or less extent of surface assumes a skin-like character and appearance. The entire tympanum, aditus, and antrum may become epidermized, but generally the epidermis extends but a short distance into the tympanum. When the attic and antrum become epidermized, their lining membrane exfoliates as the result of chronic inflammation, and Fig. 187.-Vertical sagittal section through a left temporal bone; median surface of the lateral portion. The mastoid antrum, aditus, and attic of the tympanum are filled by a cholesteatoma. The mastoid process is sclerosed and its pneumatic cells are few and small: A, Antrum containing a portion of the cholesteatoma; M, auditory meatus. (From a photograph of a specimen in the author's collection.) Fig. 188.-Lateral surface of the median portion of the same specimen. A part of the auditory meatus has been cut away and the specimen tilted toward the right in order to show the membrana tympani in the photograph, which is on a some- what larger scale than Fig. 187: A, Aditus containing part of the cholesteatoma, which extends into and completely fills the attic; the tegmen of the aditus and antrum is extremely thin and discolored about a small perforation that extends from the antrum into the middle cranial fossa; MH, malleus handle attached to the promontory throughout its entire length in such a manner that the portion of the antium anterior to the malleus is the only part of the middle ear communicat- ing with the Eustachian tube. The membrana tympani is cicatricial and collapsed. There are two large perforations posterior to the malleus handle and one anterior. Fig 187. Fig. 188. epidermic scales accumulate until the entire cavities become filled, as shown in Figs. 187 and 188. Occasionally the presence of a small collection of cholesteato- matous material in the attic will cause a discharge through a fistula over the drum-head, and this scanty discharge, drying almost as it is secreted, forms closely adherent casts of the drum-head that might easily be mistaken for the drum-head DISEASES OF THE MIDDLE EAR 435 itself. The removal of such casts from the drum-head is fol- lowed by considerable improvement in the hearing. When the attic has become epidermized, scales of epidermis will be exfoliated from time to time, until a little ball of chol- esteatomatous material will have collected in the attic and per- haps have extended into the aditus. The disintegration of such masses is a common cause of chronic suppuration and the growth of polypi. In every case of long-continued suppura- tion the presence of cholesteatoma may be suspected. It is rare to fail to remove by intratympanic syringing of the attic cholesteatomatous scales in cases of long-continued middle-ear suppuration in which the discharge originates within this cavity. The removal of such little masses, and also the granulation- tissue or small polypi that their presence commonly causes, will in most instances be all that is necessary to bring about cessation for the time being of a chronic discharge that may havepersisted for years. However, because cholesteatomatous prolongations force their way into the Haversian canals, thus forming centers from which it may grow again, even the com- pleteremoval by curettement of the lining membrane of a chol- esteatomatous cavity does not prevent a recurrence of the accumulation. In most instances where it is necessary to resort to operative procedures for bringing about a cessation of a chronic otorrhea, the mere removal of the remains of the two larger ossicles will not be sufficient, and it is far preferable to resort to a radical mastoid operation which would certainly be necessary to bring about a cure of the chronic otorrhea resulting from a condition similar to that existing in Figs. 187 and 188, for it will be ob- served that the cholesteatomatous mass occupies the mastoid antrum as well as the attic, and it would be absolutely im- possible to remove such a mass except through a comparatively large opening. However, it should be borne in mind that no operative procedure, even the removal of the lining membrane of the cavity by almost thorough curettement and the establish- ing of a large permanent postauricular opening, can be ex- 436 DISEASES OF THE NOSE, THROAT, AND EAR pected to bring about a permanent cure of chronic otorrhea due to the presence of cholesteatoma. This is perhaps due to the fact that cholesteatomatous prolongations force their way into the Haversian canals, thus forming centers from which it grows again. Reinhard states that membranes still continued to exfoliate in the cases that he had operated upon by establishing a large permanent postauricular opening into the antrum, and required removal to prevent the recurrence of suppuration; " in some more frequently, sometimes but once in three years." The same rule applies to all cases of chronic suppuration where the middle ear has become epidermized. Whether an opera- tion has been performed or not, cholesteatomatous masses will form, and their removal from time to time is necessary in order to prevent a recurrence of the suppuration. Relapses after simple mastoid operations in cases of chronic otorrhea were notoriously frequent, and in all such cases the necessity for a secondary operation is the accumulation of cholesteatomatous masses within the middle ear. In some in- stances years may elapse before such masses cause marked aural symptoms, but finally suppuration occurs, and the mastoid antrum has to be reopened to permit the removal of material that fails to find a ready exit through the tympanum and the auditory canal. Therefore it is better in cases of mastoiditis occurring in the course of chronic suppuration to do a rad- ical rather than a simple mastoid operation, except in young children. In some instances nature does a Stacke operation as the re- sult of necrosis of the lateral bony attic wall, or a large perma- nent postauricular opening may occur behind the auricle, lead- ing directly into the antrum. In either case the middle ear becomes completely epidermized; but suppuration tends to recur if epidermal scales are not removed from time to time. The advantage of such large openings, secured either by nature or by the method of Reinhard, is that epidermal scales and other debris can readily be removed, and thus a cessation of the otorrhea brought about for a time. However, it should never DISEASES OF THE MIDDLE EAR 437 be forgotten that a radical mastoid operation in most cases of recurrent otorrhea when only the atrium is involved renders the patient's condition worse rather than better, because the vast ma- jority of such cases go through life with fair hearing and only occasional suppuration, readily controlled by a competent aurist. That is, with very little if any more attention than many individ- uals require after a radical mastoid operation. SYSTEMIC DISEASES CAUSING OTIC INFLAMMATION The systemic diseases most frequently causing otitis are scarlet fever, measles, diphtheria, grip, typhoid fever, pneu- monia, syphilis, tuberculosis, and diabetes. The appearance of otic inflammation in most of these diseases is a very serious complication, and although the subject has been already discussed in sections on the etiology and path- ology of the various forms of otitis, it seems best to state briefly here the peculiarities of the otitis resulting from these systemic diseases and the modification of treatment necessary. Scarlatina.-The middle ear is frequently involved during scarlet fever. In some cases the inflammation seems to be simply catarrhal in character, probably due to closure of the Eustachian tube rather than the actual presence of the micro- organism causing the disease. Such cases run a mild course. There may not be perforation of the membrana. The deafness resulting in those cases where no perforation has occurred is often considerable. When the ear complication occurs during the eruptive stage of scarlet fever it usually assumes a severe purulent type. The membrana and ossicles may come away as a slough in a surpris- ingly short space of time, and finally large sequestra of bone. The purulent inflammation may involve the labyrinth, with resulting total deafness, or the facial nerve, causing facial paralysis. There is one practical point the practitioner should never forget, which is that the contagion sometimes lingers for several 438 DISEASES OF THE NOSE, THROAT, AND EAR months in the discharge from the ear, and that a child with scarlatinal otorrhea may be the source of infection to other children. The treatment of scarlatinal otitis differs in no respect from that of otitis from other causes, providing the condition of the patient will permit of its being carried out. The nose and throat should be cleansed once a day by the medical attendant with an atomizer containing Dobell's solution. The nose, if stenosed, should then be sprayed with adrenalin solution (1:5000) to overcome the stenosis and, finally, the mucous membrane covered with the spray of menthol-camphor-albo- lene and powdered calomel applied. The ears should now be Politzerized and, if discharging, gently syringed with a saturated boric acid solution and a piece of iodoform gauze placed loosely in the meatus. Every other day sublimate solution (1 :2000) may be substituted for the boric acid solution should the gravity of the case seem to require it. In some cases the patient, especially if a child, will be too weak or indocile to permit of so lengthy a treatment, and the practitioner may have to content himself with simply syring- ing with boric acid or sublimate solution. Sequestra of necrosed bone, polypi, mastoid complications, and intracranial involvement, if the condition of the patient permit, should be treated in the manner described in other sections. Measles.-The ear is usually affected in measles, but with less virulence than in scarlatina. The condition is usually that of the catarrhal type, acute or subacute. Rarely does per- foration occur. Treatment is the same as in similar types of otitis from other causes. Diphtheria.-Otitis media purulenta is not very infrequent in diphtheria. When the drum is perforated pseudomembranes may extend from the middle ear on to the excoriated skin of the canal. In those with otorrhea, diphtheritic pseudomen- DISEASES OF THE MIDDLE EAR 439 branous infection may occur in the tympanum if they are brought into contact with diphtheritic patients. Treatment is similar to otitis from other causes. When the membrana has ruptured and a pseudomembrane is visible the condition should be treated as described in the section on Diph- theria of the Meatus. Grip.-Aural complications in epidemics of influenza are very frequent. Minute hemorrhages into the drum-head or beneath the epidermis of the canal are not infrequently encountered and are somewhat characteristic of the disease. The aural complications vary from a subacute catarrh, from which recovery takes place within a short time, to severe otitis media purulenta with intracranial complications. The pos- sible gravity of an aural complication in a case of influenza should not be underestimated, and such a case should receive the most careful attention from its onset. The treatment is similar to otitis from other causes. Typhoid Fever.-The hebetude and apparent deafness of typhoid is due to the effect of the toxins of the disease on the in- ternal ear. Occasionally internal-ear impairment of hearing is encountered years after recovery from the fever. Purulent inflammation of the middle ear is the result of in- vasion of the bacterium coliinto the middle ear. Day andjack- son, of Pittsburg, describe three types of purulent otitis in ty- phoid--the hemorrhagic, the slow, and the fulminating. The disease is usually rapid in its onset and characterized by intense pain. Day and Jackson state that in io cases no otitis was manifest one or two days previous to spontaneous rupture of the membrana. In the Medico-Chirurgical Hospital during the Spanish War, of 268 soldiers sick from typhoid fever 3 had severe otitis media purulenta as a complication of the disease. The ear complications of typhoid occur usually in the third or fourth week. The symptoms vary from those of subacute catarrh to the severe form of middle-ear suppuration. Hemor- rhagic blebs similar to those encountered in aural influenza 440 DISEASES OF THE NOSE, THROAT, AND EAR have been observed by Day and Jackson previous to rupture of the drum-head. The treatment is that of otitis elsewhere when the condition of the patient will permit. The danger of heart failure from sitting up in bed, and nasal hemorrhage as the result of using the spray and Politzer's bag, should be borne in mind. In some cases, for a few days at least, it is best to be content with simply syringing the meatus with boric acid solution twice a day and inserting a little iodoform gauze loosely into the concha. It is better to avoid inserting gauze into the canal, especially if the dressing be entrusted to a nurse, for fear that the gauze will become impacted from some cause, possibly the finger of the patient. The gauze should be changed as often as it be- comes saturated. Pressure-pain with bulging of the drum- head will indicate paracentesis. Tuberculosis of the middle ear is probably always secondary in phthisis. Tuberculous deposits occur in the middle ear, which, after a time, break down, causing more or less rapid destruction of tissue. The most marked symptom is the pain- less character of the otitis media purulenta that results in perfo- ration of the membrana. After a considerable destruction of the drum-head has occurred the parts not infrequently become sensitive, probably as the result of mixed infection. Ordina- rily the disease pursues a chronic course, and otorrhea may even cease for a time and reappear. Sometimes the destruction of tissue is rapid and the disease extends to the mastoid, necessitating operation. Caries of the bone may involve the facial nerve and cause facial paralysis, or the internal ear may be invaded. Pus, in the more severe forms of the disease, is abundant and fetid, but tubercle bacilli are not usually numerous nor easy to find in the discharges. It should be borne in mind in this connection that otitis media purulenta may occur in a tuberculous individual without the disease being due to tuberculosis. Treatment.-The general treatment is of primary inportance and consists of a diet largely of milk and raw eggs, outdoor DISEASES OF THE MIDDLE EAR 441 life, and tonics. Local treatment is usually not very successful in bringing about a cessation of the discharge. The parts, however, in the middle-ear suppuration should be kept clean, either by the dry method or by syringing with boric acid and sublimate solution. It should be borne in mind that the dis- charges are contagious and care should be exercised to destroy all dressings used about the ear. Pneumonia.-As in typhoid, otitis media purulenta generally occurs late in the disease, if at all. The pneumococcus is not infrequently found in the pus of an otorrhea occurring independ- ent of pneumonia. The treatment is the same as in otitis occurring from other causes. Syphilis.-The middle ear is frequently inflamed during the period of secondary skin rashes and sore throat. In a case observed by the author facial paralysis occurred. The middle ear may become the seat of a gumma in the tertiary period of the disease. The symptoms at first are those of pressure within the middle ear, deafness, tinnitus, and sometimes ver- tigo. Sooner or later suppuration with perforation of the mem- brane occurs, and the disease assumes the appearance of chronic otitis media purulenta. The destruction of tissue is often considerable. Treatment.-The local treatment is that of otitis; the con- stitutional treatment being of greater importance. In cases where the diagnosis of gumma is made early, inunctions of mercury with iodid of potassium internally may result in absorption of the gumma before it breaks down. Bright's Disease.-In advanced Bright's disease all opera- tions under a general anesthetic about the nose, throat, and ear are dangerous because of the possibility of fatal coma. Diabetes.-Recurrent furunculosis of the canal may result from glycosuria. Mastoid wounds and large wounds about the upper respiratory tract do not heal as rapidly in well-marked glycosuria as in a normal individual, and otitis media purulenta runs a more severe course with greater destruction of tissue. 442 DISEASES OF THE NOSE, THROAT, AND EAR Debility and excessive fatigue or excitement reduce the acuteness of hearing very noticeably when it is already defective from middle-ear catarrh or as the result of suppuration. The same is true of shock resulting from a serious accident, even when the individual though present was not seriously injured. Under such circumstances the hearing may be seriously impaired for many months before it somewhat gradually becomes as acute as before the accident. OPERATIONS UPON THE MIDDLE EAR Operations are performed upon the middle ear for the improvement of hearing, the relief of tinnitus aurium or vertigo, and to bring about the cure of a persistent discharge from the middle ear. The operations that have been performed from time to time are quite numerous, the following being a partial list: Paracen- tesis, single or multiple; excision, or destruction by caustics of a portion of the membrana tympani for the purpose of estab- lishing a permanent opening; plicotomy or division of the pos- terior fold; section of the anterior ligament of the malleus; tenotomy of the tensor tympani or stapedius muscle, or both; division of adhesions between the membrana and promontory or between the ossicles, etc.; excision of a portion of the mem- brana; disarticulation of the incudostapedial articulation or division of the descending process of the incus and mobilization of the stapes; plastic operations for uniting either the incus or stapes with the membrana tympani; and removal of one or more of the ossicles. Severing the Incudostapedial Articulation and Mobilizing or Extracting the Stapes.-A general anesthetic may be ad- ministered, but it is preferable to operate under cocain anes- thesia in order to secure the co-operation of the patient and to test his hearing from time to time during the different stages of the operation. The field of operation is prepared, upon the preceding day, by carefully cleansing the auditory canal with a OPERATIONS UPON THE MIDDLE EAR 443 solution of hydrogen peroxid and syringing with a 1:2000 solution of corrosive sublimate, after which the auditory canal is stopped with a plug of iodoform gauze. All instruments, the absorbent cotton, and the solutions of cocain are sterilized in the usual manner by heat. Anesthesia is secured by the method of Ballin, which consists in subcutaneous injection into the roof of the canal of a mixture of equal quantities of a 1 per cent, solution of cocain and a 1:1000 solution of adrenalin (Formula 11). Fig. 189.-Pocket case instruments for minor surgery of the auditory canal and tympanum. Technic.-Commencing rather below the middle of the pos- terior periphery of the drum-head, an incision is made and pro- longed upward with the probe-pointed knife (Fig. 189) through the clear portion of the drum-head close to the annulus, beneath the posterior fold, and for a short distance downward along the malleus handle (Fig. 190). Little more than a fraction of a drop of blood ordinarily follows the incision, but the flap should be turned forward, and a pledget of absorbent cotton wrapped about the end of an Allen probe and saturated with a solution of adrenalin should be held in contact with the cut surfaces and 444 DISEASES OF THE NOSE, THROAT, AND EAR the tympanic mucous membrane until all bleeding has ceased. Before proceeding further with the operation it is well to test the patient's hearing with both voice and the watch, in order to ascertain if any improvement in the hearing has resulted from the artificial opening in the drum-head. This is rarely the case. Generally when the flap is turned forward it remains in that position, and a good view of the interior of the drum is obtained. If this is not the case, the incision should be continued down- ward along the posterior border of the malleus handle until the flap does not tend to close the wound and obstruct the view. The region of the round window should be carefully inspected and any abnormality noted and remedied, if possible, at a subsequent stage of the operation. If the incudostapedial articulation is not visible, it is brought into view by inclining the pa- tient's head strongly toward his opposite shoulder, so that it is possible to see up- ward beneath the posterior fold. The incus-hook (Fig. 189) should now be passed around the de- scending process of the incus close to the stapes and an effort made to mobilize the ossicles by gentle traction in anterior, posterior, and lateral directions, and any improvement in the patient's hearing noted. If none occurs, the tendon of the stapedius muscle should next be divided with the point of the sharp-pointed knife (Fig. 189) by a downward stroke close behind the incudostapedial articulation. Sometimes the ten- don gives way with an audible snap and immediate improve- ment in the patient's hearing follows. If, however, the hearing is not improved, the incudostapedial articulation should be severed by means of an angular knife, which is made to cut downward through the joint either from in front of or behind the incus-shank, which it hugs closely while the downward stroke or strokes are being made. If the knife cannot readily be passed beyond the incus-shank, either in front of or behind it, the joint may be severed from below with the point of the knife. Fig. 190.-Dia- gram of the left membrana t y m - pani; B, Incision through the drum- head. OPERATIONS UPON THE MIDDLE EAR 445 After the incudostapedial articulation has been severed the incus-shank is pushed forward and upward in order to diminish the possibility of its tip reuniting with the stapes. After severing the incudostapedial joint, if the patient's hearing still remains unimproved, the point of the sharp-pointed knife may be cautiously carried about the head of the stapes, within the pelvis of the oval window, and an attempt made to mobilize the stapes by means of an Allen probe about the end of which a few fibers of cotton have been wrapped. The head of the stapes should be gently pressed upward, then backward, then forward, care being exercised that sufficient force is not em- ployed to endanger fracturing the crura of the stapes, which, as the result of atrophic changes, are sometimes very fragile. If, in spite of these manipulations, the bonelet remains firmly fixed and the patient's hearing unimproved, an attempt may be made to remove the ossicle by traction with a hook. If bony ankylosis exists between the foot-plate of the stapes, Politzer has shown by experiments on the cadaver that the effort will not succeed, but that the crura will be fractured in the effort to remove the stapes. A portion of the foot-plate may, how- ever, be removed with the fragment of the crura of the stapes and the patient's hearing improved, at least for a time. After the completion of the operation the edges of the wound in the drum-head are brought together and supported by a small amount of boric acid or iodoform insufflated by the powder-blower. Ordinarily the edges of the wound quickly unite, but suppuration has been reported as following the opera- tion in a few instances. Prognosis.-In all intratympanic operations the prognosis is uncertain. The prognosis as regards diminishing tinnitus is much better than that of improving the hearing to a useful degree. The author performed this operation a considerable number of times some years ago. In many cases there was permanent improvement as regards tinnitus and temporary improvement of hearing. (See former editions of this manual for details.) 446 DISEASES OE THE NOSE, THROAT, AND EAR Operations for the relief of deafness and tinnitus resulting from chronic suppuration of the middle ear are division or divulsion of false membranes and adhesions binding the ossicles together or to the tympanic walls in such a manner as to inter- fere with the vibration of the stapes; mobilization or removal of the stapes; removal of the remains of the drum-head and the two larger ossicles. In most instances the first ossicle to become carious or necrosed as the result of chronic intratympanic sup- puration is the incus, because of its imperfect blood-supply as compared with that of the other intratympanic structures. The entire bonelet may disappear as the result of a few weeks of intratympanic suppuration. Ordi- narily the descending process is the first portion of the incus to disappear, thus freeing the stapes. The comparatively good hearing of the patients with large dry perforations of the membrana is due in many instances to the fact that the stapes is thus freed at an early stage of the suppurative process, and does not become involved by subsequent con- tractions and adhesions. In some in- stances, however, this fortunate result does not occur, and the detached stapes may be completely buried in a mass of cicatricial tissue which holds it immov- able in the pelvis of the oval window. When not detached from the incus the movements of the stapes may be inter- fered with by bands of tissue binding the two larger ossicles together or to the tympanic wall. The most common of such bands is one extending from the long process of the incus to the tympanic wall and the malleus handle (Fig. 191). Division or divulsion of such bands is, in some instances. Fig. 191.-A, Band of connective tissue extending from the long process of the incus, C, to the malleus handle, B, which was adher- ent to the promontory. Hearing for the watch in- creased from 2 inches to 2 feet as result of divulsing this band by gentle traction with an Allen probe, the point of which was bent nearly at a right angle and inserted underneath the band. The improvement lasted for nearly three years, when the operation was re- peated with equally satis- factory results. OPERATIONS UPON THE MIDDLE EAR 447 followed by the most astonishing improvement in the hearing power and the complete relief of tinnitus. In suitable cases more permanent results are secured by divulsion or stretching of the bands than by cutting them. In some cases the vibra- tions of the ossicular chain are interfered with by an adhesion of the remains of the drum-head to the promontory in such a manner as to bind down the malleus handle. Under such circumstances division of the adhesion is followed by improved hearing and decreased tinnitus. In most instances divulsion of intratympanic bands and adhesions will have to be repeated from time to time in order to secure permanent results; but as the operations are by no means formidable, when required they may be done during an ordinary office visit. In the divul- sion of bands and adhesions care should be exercised that suffi- cient force is not employed to endanger dislocation of one of the ossicles, more especially the stapes. After division of synechiae and surgical mobilizing of the stapes the hearing power can sometimes be increased by the use of an artificial drum-mem- brane; for this purpose a membrane made of paper, as first employed by Blake, answers an admirable purpose, and is sometimes followed by so much permanent improvement of the hearing that its use can finally be dispensed with. The permanent improvement is doubtless due to 11 automobiliza- tion" of the stapes during hearing as the result of wearing the disk. The removal of the two larger ossicles, or what remains of them, is admissable as a means of improving the hearing or diminishing tinnitus; but cases are hardly conceivable in which all the improvement possible, as regards both tinnitus and hearing, cannot be secured by the division of adhesions, dis- articulation of the incudostapedial joint, or mobilization of the stapes. Operation for the Removal of the Remains of the Drum- head, Malleus, and Incus in Suppurative Cases.-The opera- tion is better done under cocain anesthesia by the transfusion method of Ballin (Formula n) or a general anesthetic may be 448 DISEASES OF THE NOSE, THROAT, AND EAR employed. However, when a large amount of the intratym- panic mucous membrane is exposed as the result of disease, except in nervous patients, simply the application of a io per cent, solution of cocain yields fairly satisfactory anesthesia. If the incudostapedial articulation is intact and visible, it is well to begin the operation by severing the joint, to avoid possible injury to the stapes while removing the incus. If the membrana flaccida is intact, a sharp-pointed knife is thrust through it behind the short process, as close as possible to the margin of the annulus, and the incision continued backward and downward for a sufficient distance to completely sever the posterior attachments of the malleus. Without removing the knife from the wound its edge is turned in the opposite direction, its point is slightly withdrawn so as to ride over the malleus above the short process, and the anterior attachments of the malleus are rapidly severed. The neck of the malleus is seized with foreign-body forceps and an effort made to dis- lodge the head of the malleus from the scute or shelf of bone on which it lies on the lateral portion of the attic, by gentle pres- sure inward and downward with the forceps. Should gentle manipulation not succeed, it is probable that the malleus is held in position by adhesions to the tympanic walls. Any adhesions that can be reached should be severed by means of angular knives (Fig. 189-24 and 25). By means of one of these knives or the incus-hook (Fig. 189-29) traction directly out- ward should be made upon the tip of the malleus handle until the head of the bonelet is dislodged inward. If now the bone- let be seized in the neighborhood of the short process with the foreign-body forceps it will readily be removed by traction- at first inward and downward and then outward. The malleus when withdrawn from the ear should be inspected to determine whether or not the incus is adherent to it. In not a few instance the bonelets will be found firmly bound to- gether by bony ankylosis or strong fibrous bands, so that both bonelets will be removed together. If this does not occur, and the presence of the incus has been determined previous to the OPERATIONS UPON THE MIDDLE EAR 449 operation by the use of an Allen probe, the tip of which has been bent upward andguarded by a few fibers of cotton wrapped about it, a diligent search should be made for the incus by means of incus-hooks. (Fig. 189-10, 14, 15.) The incus will prob- ably be found behind the annulus, dislocated downward and outward as the result of the withdrawal of the malleus. The tip of its long process will probably be found close behind the annulus posteriorly and somewhat below the middle of the tympanum. If the incushook be introduced into the lower part of the tympanum, with its concave surface upward and the tip of the hook behind the annulus, by lifting the hook slightly upward and at the same time rotating it the long process of the incus will probably be pushed anteriorly into view from behind the annulus. In executing this maneuver it is necessary that the tip of the hook be held somewhat closely in contact with the median surface of the annulus. The ota- tion of the hook may have to be repeated several times be- fore the incus-shank is brought into view. The ossicle will probably be found lying somewhat lower down in the tym- panum than would naturally be expected, but if careful mani- pulation of the hook fails to locate it in this region, the ossicle should be searched for higher up, and if necessary the other hook may be inserted with its concavity down- ward and its tip behind the scute, and rotated in such a manner as to dislocate the ossicle downward. This maneuver should be executed with great care and gentleness, as there is danger of pushing the ossicle backward into the antrum. After the incus is brought into view it should be seized with the forceps manipulated in such a manner as to free it from the annulus and withdrawn. It should be borne in mind that the first portion of the ossicle destroyed By caries is the long process, and that it sometimes requires but a short period of suppuration to cause the entire destruction of this ossicle. Too prolonged search for the incus after the removal of the malleus is not advisable, unless it is certain from previous examinations that the incus is certainly present. 450 DISEASES OF THE NOSE, THROAT, AND EAR After the withdrawal of the incus, the edge of the annulus and the tympanic vault should be carefully searched by means of a cotton-tipped probe for exposed bone or areas of granula- tions. If such spots be found, they should carefully be curetted by means of a bent curette (Fig. 189). The success of the opera- tion in bringing about a cessation of persistent or recurrent suppuration will often depend upon the thoroughness and care Fig. 192.-Vertical frontal section through the middle of the external meatus: A, Anterior, P, posterior portion of the specimen; 5, scute or external bony wall of attic; C, carotid artery; J, internal jugular vein. The carotid is separated from the anterior median wall of the tympanum by an extremely thin septum of bone, which in numerous instances is entirely lacking, so that the vessel might be wounded by the knife of a heedless operator during an intratympanic operation. The bulb of the jugular vein is separated from the cavity of the tympanum by the mucous membrane and a thin septum of bone that is sometimes lacking. The bulb of the. jugular vein has been wounded during the operation of paracentesis. In the specimen the drum-head, malleus, and incus have disappeared as the result, probably, of chronic suppuration. (Author's specimen.) with which this is done. Any remaining portions of the mem- brana should also be removed with the probe-pointed knife or with a curette. In operating upon the anterior or inferior portion of the tym- panum the position of the carotid artery and the bulb of the jugular vein should be borne in mind (Fig. 192, 210, 217). OPERATIONS UPON THE MIDDLE EAR 451 Ordinarily the jugular vein is covered by bone of sufficient thickness to prevent injury to the vessel, but sometimes this bone is lacking and the vein lies just below the tympanic mucous membrane. Several cases of injury to the jugular vein during intratympanic operations have occurred, but with- out fatal results. Although no cases of injury to the carotid artery during operations upon the middle ear are known, yet Fig. 193.-Adult temporal bone, with the upper and part of the posterior wall of the meatus chiseled away so as to form one large cavity of the meatus, tympa- num,. and antrum: A, Hard ridge of bone surrounding the Fallopian canal. Within the tympanum the oval and round windows are plainly shown. It should be dome in mind that the facial nerve arches backward above the oval window and then descends vertically (Figs. 137, 138, 213, and 214). .The inner end of the ridge of bone between the auditory canal and mastoid near A is, therefore, not far distant from this nerve, and considerable caution should be used in smoothing down this portion of the ridge, the outer portion of which can be removed quickly with rongeur forceps without pain or difficulty. In a complete Kiister operation healing will be facilitated and a better final result obtained by removing not only the ridge, between the canal and the operative cavity in the mastoid but also the overhanging edge of bone about this cavity, both above and behind, to render the operative cavity as flat, smooth, and shallow as possible. The root of the zygo- matic process and the tip of the mastoid contain cells, and in most instances it is desirable to open these cells thoroughly. The ridge between the canal and the operative cavity and overhanging edges have been allowed to remain in order to better show the topography. (Author's specimen.) the artery lies dangerously near anteriorly, and it is well to use a probe-pointed kinfe when operating in this locality. Hemorrhage from this portion of the artery as the result of necrosis has almost invariably terminated fatally, even after ligation of the internal carotid artery. After the removal of the malleus and incus, if it be deemed 452 DISEASES OF THE NOSE, THROAT, AND EAR necessary in order to gain better access to the attic for after- treatment, the lateral wall of the attic may be removed by means of a small chisel or curette (Fig. 208). The after-treatment of the operation consists in daily cleans- ing of the parts with absorbent cotton and the insufflation of powdered boric acid. Fig. 194.-Vertical frontal section through the external auditory canals of a fetus stillborn at the end of the seventh month, anterior portion of the head. The external auditory canal slopes somewhat downward and the membrana tympani are nearly horizontal. The lower wall of each canal is in contact with the upper except for the presence of a small quantity of the same cheesy material {vernix caseosa) that covered the rest of the skin of the fetus. The tympanum is completely filled by the ossicles and its own mucous membrane, which is much thicker than that of the adult. The malleus is in position in the right ear, but has been removed by the saw from the left: B, Brain; M.H, head of the malleus; C, cochlea of the left ear. (Author's specimen.) Mastoiditis. The External and Middle Ear of a Newborn Child.-At birth the external meatus is essentially a closed canal. The drum-head lies nearly in the same plane with the upper wall of the meatus (Fig. 194), and forms such an extremely acute angle with the lower wall that the upper and lower walls are practically in contact except for the vernix caseosa, which, covering the entire body of the child at birth, also extends into the auditory canal, completely blocking it up so that no air can enter. The drum-head is covered by OPERATIONS UPON THE MIDDLE EAR 453 extremely thick epidermis, while the cavity of the tympanum is usually completely filled with its own mucous membrane, which, Fig. 195.-Left half of the skull of a stillborn infant, showing the inferior sur- face of the petrous bone, the annulus tympanicus, the ossicles, the tympanum, and the mastoid process. The ossicles, the tympanum, and the mastoid antrum are nearly as large as those of an adult: M, Mastoid process. The end of the line is at the stylomastoid foramen. Hence, at birth the facial nerve emerges not, as in the adult, on the inferior, but on the lateral, surface of the temporal bone. Therefore it readily may be wounded during a mastoid operation by a careless operator or injured by too tightly packing or bandaging the mastoid wound; S.P, short process of the malleus; P.T, posterior tubercle of the annulus tympanicus. (Author's specimen.) Fig. 196.-Same specimen as Fig. 19s, but with the mastoid antrum exposed, showing its normal position at birth immediately above the posterior tubercle of the annulus, in most instances it has assumed the position of adult life when the child is two years old. enormously hypertrophied at all parts of the tympanum, is thickest upon the inner wall, where it is markedly hyperemic 454 DISEASES OF THE NOSE, THROAT, AND EAR and jelly-like in appearance, in marked contrast to that of adult life, which upon the promontory is thin and nearly bloodless in appearance. Hence, the offspring of the human race, like that of many of the lower animals, is born into the world almost completely deaf. Almost from birth the eyes of the infant follow the movements of individuals about the room, but it is not until the eighth or tenth day after birth that an infant shows any Fig. 197.-The temporal bone of a newborn child separated into its three com- ponent parts: the squamous and petrous portions and the annulus tympanicus or processus auditorius (Gray). evidence of hearing the sound of a tuning-fork held close to its ear. At birth or soon afterward the tympanum becomes a cavity containing air. The thick epidermis of the outer layer of the drum-head is exfoliated and the mucous cushions within the tympanum disappear. The temporal bone ossifies from eight centers. These have coalesced at the end of the fifth month but even at birth, the bone readily separates into three parts, Fig. 197. The osseous ORERATIONS UPON THE MIDDLE EAR 455 canal of the adult is represented in infants by the annulus tympanicus or processus auditorius (Figs. 195, 197), which forms by gradual development the vaginal process of the auditory meatus of the adult. The rest of the canal is composed largely of embryonic tissues covered by skin, and measures from the tragus to the umbo usually about 30 mm., while that of the adult measures from 31 to 35 mm. between the same struc- tures. Because of the nearly horizontal position of the drum- head, Shrapnell's membrane (Fig. 135) lies so near the orifice of the canal that when greatly swollen it almost protrudes, re- sembling a polypus somewhat in appearance; indeed, it has been mistaken for a polypus and removed, together with the malleus and incus. To examine the drum-head of young children it is necessary to draw the lobule downward in order to detach the lower from the upper wall of the meatus. The ossicles, tympanum, and mastoid antrum are nearly as large as those of an adult, but are superficially situated, and in opening a mastoid abscess in an infant, therefore, it is not unusual for the probe to pass through the antrum into the attic for a distance of nearly 1 inch. The mastoid antrum of young infants is situated immediately above the posterior tubercle of the annulus (Fig. 195), and this ele- vation should be searched for as a landmark when operating upon the temporal bone of infants. It should also be borne in mind that the mastoid-squamous suture (Fig. 195) is not ossi- fied at birth, and frequently presents large dehiscences during childhood, so that when making the primary incision for a mastoid operation upon a young child the point of the knife should not be pressed with force against the bone or it may enter one of these dehiscences and penetrate the cranial cavity. The incision should be made with due deliberation until the bone is exposed in the whole length of the incision, and the periosteum pushed forward with great care and gentleness. It should be borne in mind also that at birth the facial nerve emerges not on the inferior surface, but on the external (lateral) surface of the temporal bone, at a point close to the annulus 456 DISEASES OF THE NOSE, THROAT, AND EAR and somewhat above its inferior border (Fig. 195). Unneces- sary curetting within the mastoid antrum and attic should also be avoided, as the petrosquamous suture, where the horizontal plate of the squamous portion of the temporal bone unites with the petrous portion to form the tegmen or roof of the tympanum and antrum, remains open for some time after birth, and a process from the dura not infrequently extends downward to unite with the mucous membrane of the middle ear. The Adult Mastoid Process.-At birth the mastoid process consists of a small flattened tuberosity containing but one cell, Figs. 198 and 199.-Large-Celled pneumatic processes: the tip of the one to the left diploetic. (Author's specimens.) the mastoid antrum. At the age of eight years the child's mastoid generally contains numerous other pneumatic spaces radiating from the antrum. At puberty the mastoid has be- come a distinct prominence, conic in shape, with its apex downward. It may or may not contain pneumatic cells in addition to the antrum. Types oj Mastoid Structure.-There are four distinct types of mastoid structure: 1. The pneumatic, in which the whole mastoid process is composed of pneumatic spaces communicating with each other and with the antrum, and lined with a continuation of the mu- cous membrane of the middle ear. The pneumatic spaces may be large (Figs. 198 and 199) or small (Figs. 200 and 201). OPERATIONS UPON THE MIDDLE EAR 457 If the pneumatic spaces are small, one comparatively large cell is generally found at the mastoid tip. 2. The diploetic, the entire bone containing no air-spaces, but composed of diploetic tissue. 3. The pneumodiploetic, in which pneumatic spaces and diploetic tissue are both found (Figs. 198 and 199). 4. The sclerosed, in which the entire bone is composed of compact bone often as hard as a tooth (Fig. 202). Pathologic Importance of Types.-Pathologically and sur- gically the structure of the mastoid process is of the utmost Figs. 200 and 201.-Frontal section through the spina of a mastoid process consisting almost entirely of small pneumatic cells: Fig. 200, Anterior, Fig. 201, posterior portion of the specimen; A, antrum; C, large cell at the tip of the process; the semicircular canals and the aquaeductus Fallopii have been laid open after the section was made. (Author's specimen.) Fig. 200. Fig. 201. importance. In the pneumatic type of mastoid with large cells, pus from the antrum readily finds its way to the lateral surface, but in the diploetic, and more especially in the sclerosed type, there is greater danger of pus burrowing its way into the cranial cavity. The difficulties of the mastoid operation are also greatly increased by the compactness and hardness of the bone. Where a large cell is present at the mastoid tip with a thin median wall, pus is more likely to find its way into the digastric fossae than to penetrate the thicker external cortex. Long narrow or dolichocephalic skulls have pneumatic processes 458 DISEASES OF THE NOSE, THROAT, AND EAR oftener than brachycephalic or round skulls. In round skulls the external canal is proportionately longer, that is, the ear lies deeper. Often there are no cells, so that the sinus and dura are very close to the external meatus and the middle ear (Fig. 210). Etiology.-Primary inflammation of the mastoid rarely oc- curs except as the result of syphilis, tuberculosis, or traumatism, especially in individuals with chronic suppuration of the tympanum and attic. The symptoms are those of acute peri- ostitis, pain, heat, and swelling behind the ear. Within a few days the perios- titis subsides or the deeper structures become involved. In such cases should caries occur, the abscess-cavity does not usually communicate with the mastoid antrum, but is generally superficially situated beneath the cortex of the bone. However, the disease in almost every instance is the result of an extension, by continuity of structure, of inflammation from the tympanum. Mastoiditis, then, is generally the sequence of acute in- flammation of the tympanum or of chronic suppuration of the middle ear. In rare instances suppurative inflamma- tion of the deeper portion of the audi- tory canal may extend under the periosteum until pus ap- pears upon the external surface of the mastoid beneath the periosteum (Fig. 203); or infection may be transmitted by means of the veins which traverse canals from the meatus into the mastoid cells. Pathology.-Koerner divides the suppurative processes within the mastoid into: 1. empyema; 2. softening and dissolution of the bony substance, and 3. necrosis. Empyema is restricted to suppuration within the cell spaces without in- Fig. 202.-Vertical sagittal section through a sclerosed mastoid proc- ess, the cellular structure of which, with the excep- tion of an exceedingly small antrum, has been entirely replaced bjr dense eburnated bone. (Author's specimen.) OPERATIONS UPON THE MIDDLE EAR 459 volvement of their bony walls. This condition frequently occurs on the third or fourth day of acute otitis and recovery usually results without destruction of bone if there is free drainage through the tympanum. Dissolutions of bony sub- stance is brought about by swelling of the inflamed mucous membrane and periosteum lining the cells which finally com- pletely fills them. A further increase takes place at the ex- pense of the bony septa which soften and disintegrate, and a large amount of pus is usually poured out by granulation-like tissue which escapes through the tympanum. This process may invade the diploea or break through the mastoid cortex. Fig. 203.-Periostitis and necrosis of the petrous portion of the temporal bone after otitis media, in a boy three years of age. The presence of pus beneath the perioteum produces the characteristic appearance of the ear being pushed outward from the side of the head (Friihwald). Necrosis resulting from acute purulent otitis media is more frequent in young children than adults, in whom it is not unusual to find a sequestrum during a mastoid operation. However, necrosis is much rarer than the former condition which is sometimes, even at present, called caries. Necrosis is a slower and usually less painful process than caries. It may follow scarlet fever; hereditary syphilis and tuberculosis are said to be predisposing causes. The symptoms are at first similar to caries but perforation of the cortex occurs earlier when the parts assume the appearance shown in Fig. 460 DISEASES OF THE NOSE, THROAT, AND EAR 2i4 as the result of pus beneath the periostium. In tubercular adults the process often runs a chronic course, months or even years being required for the sequestrum to become separated. If operated upon before this occurs the air cells will be found empty or partly filled with a thin foetid pus, and mucous membrane and bone are pale and bloodless. It is important in operating on such cases to produce a bone wound that bleeds from its entire surface. Otherwise it is probable that it has not extended beyond the necrotic area and that a sequestrum will form and require removal, before the wound will heal. In most chronic cases the mastoid antrum becomes filled with cholesteatomatous masses, thus isolating the mastoid cells from the tympanic cavity. Active mastoid complications during chronic suppuration of the middle ear frequently manifest themselves during an acute exacerbation of the middle-ear disease, with the result of producing an acute inflammation of a limited area of bone in the center of a sclerosed mastoid. Caries or necrosis of the mastoid may extend inward and involve the lateral sinus, producing phlebitis, thrombosis, embolus, and their consequences. The middle fossa of the skull may also be penetrated and an abscess produced beneath the dura mater, a local pachymeningitis preventing further extension of the disease; or meningitis, both at the base and convexity of the brain, or brain-abscess may occur. Symptoms.-In acute cases the first symptom is intense pain, involving the mastoid and often the whole side of the head. The patient's face assumes the expression of abject woe. He eats little and sleeps less. There are tenderness on pressure over the mastoid, fever, and in most cases swelling and congestion of the upper posterior part of the meatus. In the more chronic form of the disease the patient is sometimes remarkably free from pain, almost the first symptom to which the surgeon's attention is called being congestion of Shrapnell's membrane, with swelling at the inner upper posterior part of the meatus, over the mastoid, or of the neck below the ear. Especially in OPERATIONS UPON THE MIDDLE EAR 461 children, the external cortex of the mastoid may be penetrated early in the disease and the pus find its way underneath the periosteum. Under such circumstances the whole auricle, when seen from the rear, appears as if pushed out from the side of the head (Fig. 203). A symptom of considerable diagnostic importance is sudden cessation of discharge from the meatus in the course of an acute otorrhea. It is probably caused by lack of sufficient drainage from the attic and antrum. If the discharge is not re-estab- lished within a few days, mastoid symptoms requiring opera- tive interference generally manifest themselves. Granulations protruding through a perforation should be removed to secure better drainage. If pus exudes through a tit-like mass of swollen tissue on Shrapnell's membrane, the mass should be snared or cruetted away, as very often these procedures are sufficient to secure rapid subsidence of mastoid symptoms. In cases requiring operation the temperature is not a very re- liable guide. In some cases it .may be very little if any above normal. Pain on pressure over the antrum or at the mastoid tip may disappear. However, when in conjunction with ten- derness on pressure over the antrum, which has been present for some days, there is swelling of the posterior wall of the meatus close up to the drum-head, so that a portion of Shrap- nell's membrane is hidden, an operation should not longer be delayed, as such cases rarely or never recover without it. How- ever, when the large cells at the tip of the mastoid are princi- pally involved there will be no bulging of the canal, but never- theless an operation is imperative. In making pressure over the antrum the observer should insert his finger at a level with the superior border of the meatus into the angle made by the junction of the auricle with the mastoid and press upon the bone in a direction backward and inward, being careful to move the auricle as little as possible, so as not to mistake the the pain commonly caused in acute suppuration of the middle ear by movements of the auricle for bone tenderness over the antrum. 462 DISEASES OF THE NOSE, THROAT, AND EAR A small lymphatic gland is found upon the surface of the mastoid about | inch posterior to the meatus. Tenderness of this gland should not be mistaken for the bone tenderness of mastoiditis. Should this gland become infected and break down as the result of furunculosis of the canal or other causes, the pus will be beneath the skin and not beneath the periosteum, and consequently the auricle will not, when seen from the rear, appear pushed out from the side of the head. Such superficial abscesses simply require opening and not a mas- toid operation. Persistent tenderness of the mastoid tip and swelling of the tissues of the neck behind and below the mastoid indicate the presence of pus in the digastric fossae as the result of suppura- tion of the large cell at the tip of the mastoid. Usually the median bony wall of this cell is thinner than the external cortex and breaks down more readily. In such cases the entire tip of the mastoid should be removed at the mastoid operation and the abscess cavity in the tissues of the neck laid freely open. If a bacteriologic examination of the discharge from the meatus shows the presence of streptococcus, Friedlander's bacillus, or the encapsulated streptococcus, it is wise to operate earlier than if staphylococci only were present. A blood- count should be made, but only in a few doubtful cases will an increase in the polynuclear neutrophiles prove a safe guide when suppurative lesions of other parts of the body can be excluded. A negative blood-count should not deter the surgeon from opening the mastoid should the symptoms manifestly require it. Atypical cases are those where the disease progresses with- out well-marked symptoms-the so-called "latent mastoiditis." The onset, corresponding to the invasion of the middle-ear, may be so slight as not to be perceived by the patient, or there may be a tonsilitis of a day or two's duration, followed by dull pains in the ear, and imparied hearing. The pain soon subsides, and the patient forgets that he has had any trouble until after a time, varying from two or three weeks to several OPERATIONS UPON THE MIDDLE EAR 463 months, when he is suddenly seized with severe pain, in the mastoid. Examination at that time will show pronounced mastoid tenderness on pressure, usually at the tip. The subjective pain, however, may radiate over the entire side of the head. The drum-membrane will appear normal in color, or there may be a slight lack of luster, and possibly injection of the malleus handle. In the majority of cases there is impaired hearing; which is only incidentally the case in hysterical mastoiditis, mastoid neuralgia, or in the pain referred to the mastoid in sclerosis, Fig. 202. The appearance of the drum-head is often normal or nearly normal both in latent mastoiditis and mastoidalgia but tenderness on pressure is persistently present either over the antrum or the tip in latent mastoiditis. In some cases comparison of the per- cussion note of each mastoid, transillumination or the x-ray yield valuable information. In doubtful cases there should be no hesitancy in opening the mastoid cells. The drum-head does not break down because of the mild virulence of the bac- teria present in these cases or the possibility that the drum was thick and abnormally resistant. The fact that mastoid abscess with intracranial complications may occur months or even years after a suppurating ear has apparently healed is probably due to some infective focus of pus in the mastoid cells which remains latent. Especially in diabetes, but also in influenza, pnuemonia, typhoid and the exanthemata rapidly extending suppuration and softening of the bone may occur without pain, fever, or other marked symptoms. Such cases are most common in diploic mastoids with a cortex sufficiently thick to prevent great tenderness on pressure over the dis- eased area and the process may extend to a general osteomy- elitis beyond the limits of the temporal bone or meningitis or sinus thrombosis. Treatment.-'When there is congestion of the posterior portion of Shrapnell's membrane and swelling of the neighboring tissues of the meatus, a free incision through Shrapnell's membrane and the swollen tissue will sometimes abort the 464 DISEASES OF THE NOSE, THROAT, AND EAR attack (see p. 420). The mastoid process should be thickly covered with an ointment of 20 per cent, ichthyol in lanolin. The parts should then be covered with waxed paper and bandaged in order to prevent soiling the patient's clothing or bed-linen. Pain is best combated by the application of dry heat by means of a hot-water bag. If absolutely necessary, an anodyne should be administered. Pain often can be relieved entirely for days by the application of cold to the mastoid process, either in the form of an ice-bag or Leiter's coil. However, this method is becoming less popular, as cold does not control the suppurative process, but simply masks its symptoms. The application of heat is the better treatment. With the object of promoting the reaction of inflammation, 1:5000 hot bichlorid irrigations every hour have been made; and for the same purpose, Bier's treatment by constriction of the neck with an Esmarch elastic band applied only sufficient ly tight to produce slight constriction of the neck, but no pain or discomfort, has been used. The bandage is applied four times in twenty-four hours with intervals of two hours between the applications, and the foot of the bed is slightly raised. Painting the mastoid process with iodin or cantharidal col- lodion renders the skin so sore that it is difficult to determine whether tenderness on pressure is the result of the counterirri- tant or inflammation of the bone. Although a favorite method of treatment with the aurists of half a century ago, it is doubtful if counterirritation over the mastoid ever accom- plished an appreciable amount of good. The writer has been called in consultation to see 2 cases of erysipelas apparently resulting from the application of cantharidal collodion over the mastoid. One of these cases, an old man with advanced chronic Bright's disease, proved fatal. If, notwithstanding the application of ichthyol over the mastoid, dry heat, and the systematic treatment of the tym- panic suppuration, the tenderness over the mastoid is not OPERATIONS UPON THE MIDDLE EAR 465 relieved, and pain, sleeplessness, and loss of appetite increase, it is necessary to operate. The prognosis in uncomplicated mastoiditis is favorable. The major portion of cases recover with or without operation. The mastoid tenderness occurring in a large proportion of cases of acute suppuration of the middle ear within a few days of the onset of the disease commonly disappears within a short time as the result of treatment. The more severe forms of the disease occurring later, providing there is no swelling of the tissues at the inner upper portion of the canal, frequently re- cover without operation if properly treated, if the infection is not due to the presence of streptococci or the result of grip. The prognosis in scarlatina, tuberculosis, diphtheria, etc., is, of course, more uncertain with or without operation. However, an early mastoid operation subjects the patient to practically no risk, and when in doubt as to the advisability of operating the patient's interests, both as regards the risk of life and the integrity of the organ of hearing will be conserved by giving the benefit of the doubt in favor of the operation. Even if the surgeon has the mortification at the operation to chisel through absolutely normal bone to an antrum but slightly inflamed, there is usually a rapid cure of the otorrhea, and such procedures may be considered as similar to the explora- tory incisions of the general surgeon. Technic.-The instruments required for the performance of the mastoid operation are scalpels, 6 hemostats, 2 Jansen's dilators (Fig. 207), 3 bone-gnawing foceps (Figs. 205, 206), 3 bone gouges (Fig 209), a mallet, bone curettes (Figs. 204, 208), periosteal elevator, grooved director, and a probe. While opening the mastoid is generally performed for liberating the contents of a septic cavity, it should be done under antiseptic precautions. The instruments should be sterilized by boiling them in a 2 per cent, soda solution and the hands of the operator and those of his assistants disinfected in the usual manner. The patient's hair should be shaved off for a distance of about 2| inches above and behind the ear to 466 DISEASES OF THE NOSE, THROAT, AND EAR be operated upon. The skin covering the field of operation should be disinfected in the usual manner and the auditory Fig. 204.-Whiting's mastoid curette. There are several sizes of this instru- ment manufactured. The medium size is the most useful; but during an operation the largest and smallest sizes should be on the instrument table, as they are oc- tasionally required. canal syringed with warm bichlorid solution. These prepara- tions of the patient for operation are better made previous to Figs. 205 and 206.-Hartmann's curved rongeur forceps. Four or more sizes and kinds of rongeur forceps are convenient for mastoid operations and opening the cranial cavity. A fairly practical outfit consists of Hartmann's curved, half- curved, and angular mastoid rongeur forceps, Jansen's small double curved forceps and Keen's craniotomy forceps. giving the ether. If the patient's hair is long it should be covered by a towel wet in bichlorid solution or a rubber cap If the drum-head has not been perforated during the cours. OPERATIONS UPON THE MIDDLE EAR 467 of the disease, it is best to preface the operation by an incision around the posterior periphery. An incision is made through the skin to the bone from the tip of the mastoid to a point above the helix. The incision should be close to the insertion of the auricle. In children this incision should be made somewhat deliberately, with the edge of the knife rather than its point, so that there will be no danger of thrusting the knife-point deeply into a dehiscence of the bone. In infants the incision should be far enough back to avoid injuring the facial nerve (Figs. 195, 196). In adults the tip of the mastoid should be located with the end of the index- finger of the left hand and the point of the knife thrust at once through skin and periosteum into the bone. Maintaining firm pressure with the knife-point against the bone, the incision is continued upward around the auricle to stop at a point just short of the temporal artery, the exact position of which has previously been located with a finger-tip of the left hand. If the incision is made in this manner it will cut through the peri- osteum the entire length of the cut. After the incision has been made several little spurting arter- ies will require clamping with hemostats by the operator or his assistant, and if the parts are brawny and swollen there will probably be a somewhat profuse venous hemorrhage from all parts of the wound, which will be lessened if the head of the operating table is slightly elevated. It can be controlled by the application of hot water or may be disregarded until the periosteum is separated from the bone, as it will cease after Jansen's dilator has been applied. If the mastoid process is large it may be desirable to secure additional space by making an incision about 1 inch in length at right angles to the original incision from the center of the auditory meatus toward the occipital protuberance. The presence of this second incision not only secures additional space, but has the advantage that the two posterior triangular flaps fall away from the bone and do not require the use of a dilator to hold the wound open. The periosteum should be separated from the bone with 468 DISEASES OF THE NOSE, THROAT, AND EAR every precaution to avoid tearing it. It peals off from the bone very readily except where the bone is rough, at the tips of the mastoid, where the strenocleidomastoid muscle is attached. Here some patience and skill are necessary to avoid tearing; the best instrument for the purpose being the hoe-shaped periosteum elevator of Langenbeck or one of its modifications. As soon as the periosteum has been separated from the bone, Jansen's dilator (Fig. 207) is inserted in the wound. As the instrument is opened by means of the thumb-screw the wound becomes widely dilated and the pressure on the soft parts is sufficient to cause all hemorr- hage to cease. Two of these instru- ments should be used, one at each extre- mity of the wound. The hooks of the in- struments should be kept closely in con- tact with the bone as the blades are opened in order to grasp all of the tissues efficiently. When the surface of the mastoid has been uncovered by the separation of its periosteum, it should be inspected carefully with a probe for the presence of any sinus or soft spot leading to an abscess-cavity. If such a sinus is found it should be explored with a probe passed in the direction of the antrum and Fig. 207.-Jansen's dilator. Fig. 208.-Gleason's double-end bone-curette with curved tip. the softened cortex of the mastoid removed with a curette (Fig. 204) or bone forceps (Figs. 205, 206), used in such a man- ner as not to endanger the lateral sinus (Figs. 210, 211). When the cortex has been sufficiently removed it may be found that the entire mastoid is a cavity filled with pus and pulpy granulations, every trace of cellular structure having OPERATIONS UPON THE MIDDLE EAR 469 disappeared. This condition of affairs is most likely to occur in large-celled pneumatic mastoids. The pulpy granulations Fig. 209.-Alexander's mastoid gouges. These instruments are marked accord- ing to their width in millimeters, 14, 10, 8, 4 are the most useful sizes, similar chisels are made, but are not as useful as the gouges. and debris should be scraped away with the curette until firm normal bone is encountered. However, the curette should be Fig. 210.-Horizontal section through a right temporal bone below the spina, showing an extreme anterior and superficial position of the sigmoid sulcus, thus bringing the lateral sinus within 1.5 mm. of the bony surface at the operating point and rendering the ordinary mastoid operation impossible. At a position some- what above the operating point the sulcus is less than J mm. from the bony sur- face: V, Upper, L, lower portion of the specimen; S.C, sigmoid sulcus; T, tym- panum; At, attic; A, small antrum; S.S.M, spina suprameatum. (Author's specimen.) used with gentleness and judgment in positions where the lat- eral sinus is likely to be encountered, so as not unnecessarily 470 DISEASES OF THE NOSE, THROAT, AND EAR and unexpectedly to expose or wound this important vessel. The position of the mastoid antrum should also be located, and when working toward it with the curette the position of the aqueductus Fallopii (Figs. 137, 138, 193, 213) should be borne in mind, so as to avoid danger of curetting away a part of the facial nerve. Fig. 211.-Right temporal bone, showing: I, Opening the antrum after Schwartze; 2, point where the chisel is first inserted in removing the posterior wall of the meatus after Wolf; in the radical mastoid operation-in this space is the spina supra- meatus; 3, the same after Stacke; 4, portion of mastoid process removed in same operation; 5, exposing the sinus and cerebellum; 6, exposing the cerebrum (temporal lobe); 7, spur; sometimes mistaken for the spina suprameatum; 8, middle meningeal artery; 9, second temporal fissure; 10, first temporal fissure; II, fissure of Sylvius; 12, mastoid foramen. (Bruhl and Politzer.) The floor of the mastoid antrum lies just behind and below the spina suprameatum (Fig. 211), in a direction parallel to the bony meatus. If the operator is in doubt as to the direction of the bony meatus, it is permissible to insert a probe between the bony and membranous meatus so as to be absolutely sure as to the proper direction in which to continue the use of the curette OPERATIONS UPON THE MIDDLE EAR 471 or the chisel. Not infrequently after the abscess-cavity in the mastoid has been cleansed there will be found a small opening into the antrum, if, indeed, any exist large enough to permit the passage of a probe. The bone in this locality is usually soft enough to permit it being readily scraped away with the curette, but if not, a gouge should be used in the following manner: The edge of an 8 mm. gouge with its convexity forward is placed upon the bone about 2 mm. posterior to the superior suprameatus and struck one or more sharp blows with the mallet in such a manner that it penetrates the bone to a considerable distance parallel to the canal. The gouge is then placed just beneath the linea temporalis slightly poste- rior to the meatus and struck with the mallet so that the chisel penetrates the bone in a direction toward the antrum; that is slightly downward, inward and forward. The triangular space of bone thus outlined corresponds with the upper por- tion of Macewen's triangle and is removed layer by layer with the gouge from behind forward until the antrum is opened. The operator can assure himself that it is certainly the antrum that is opened by passing a probe forward and inward through it into the attic. Fluid syringed into the antrum should appear in the meatus unless the aditus or attic is filled with granula- tions or the drum-head is not perforated. Should this be the case, they should be removed by means of a small curette (Fig. 189), being careful not to dislocate the incus during the procedure. However, should it prove impossible to syringe from the attic into the meatus, no especial harm need be apprehended. Formerly, when the main abscess-cavity had been thoroughly cleansed and a free communication established between the mastoid antrum and the external wound, the operation was considered complete. The larger proportion of cases operated on in this manner make an uneventful recovery and the result- ing scar or deformity is inconspicuous. However, there are often a few cellular spaces above the meatus in the root of the zygomatic process, so that in cases where the operation results 472 DISEASES OF THE NOSE, THROAT, AND EAR in the formation of a discharging sinus, the fistula frequently leads to one of the cell-spaces that was not thoroughly opened at the time of the operation. Hence the disposition has been to make the bone wound larger than formerly by chiseling away the overhanging edge of bone above and behind the meatus at the root of the zygoma. Not only are all cell- spaces, if present in this locality, by this method of operating removed, but the mastoid antrum is thoroughly exposed and becomes the bottom of a shallow cup-shaped cavity from which exuberant granulations can readily and thoroughly be scraped away. All cellular structures should be removed by a curette rotated on its long axis until every portion of the bone wound is firm and hard to the touch of a probe which should be fre- quently applied during the curettage to be certain that the cranium has not been opened inadvertently and the dura ex- posed. As the cells overlying and posterior to the compact bone of the sulcus of the sigmoid sinus are removed the convex outer surface appears bulging into the bone cavity. The wall of the bony external meatus should not be interfered with or collapse of the cartilaginous portion will occur when healing is complete. In the tip of most mastoid processes there usually is a large cell even when the bone is of the small-celled diploetic type (Fig. 198, 199, 200, 201). It is best in all cases, therefore, to remove the cortex of the mastoid tip and thoroughly expose this large cell, if present, to inspection. If it be filled with pulpy granulations, these should be scraped away until the normal bone beneath has been thoroughly cleansed and exposed. In a small percentage of cases abscess of the large cell in the tip of the mastoid results in perforation through the median wall and the gravitation of pus into the digastric fossa and beneath the sternocleidomastoid muscle into the deeper tissues of the neck. Under these circumstances it is necessary to removed the entire tip of the mastoid and thoroughly expose the abscess-cavity. The incision through the skin should be lengthened along the anterior border of the OPERATIONS UPON THE MIDDLE EAR 473 sternocleidomastoid muscle, and the attachment of the muscle to the end and median surface of the tip severed with scissors held as close to the bone as possible, after which the tip is very readily removed with the rongeur forceps (Figs. 205, 206). Newmann removes the tip with a bone gouge which is placed vertically on the mastoid at the lower border of the meatus and struck a sharp blow with the mallet. This process is repeated at the posterior border of the tip and its fracture is complete. The tip is then seized with forceps and subluxed outward, the muscle fibers being cut away with scissors. Instances where the median surface of the large cell at the tip of the mastoid is perforated, with the result of the gravitation of pus into the digastric fossa and the deeper tissues of the neck, were first described by Bezold, and are hence frequently referred to as Bezold cases. They are characterized by a brawny swelling below and behind the mastoid, and movements of the neck are extremely painful to the patient. Not only is it necessary to remove the entire tip of the mastoid in such cases, but the abscess-cavity in the tissues of the neck should be thoroughly laid open by a free incision through the skin. The sternocleidomastoid is attached not only to the tip of the mastoid process, but to the base of the skull posteriorly, and severing its attachment to the mastoid does not apparently impair its functions. However, except in Bezold's cases, it is manifestly not absolutely necessary as a mere matter of routine to remove the entire tip of the mastoid and expose the diagas- tric fossa. If no softened spot or sinus is found upon the surface of the mastoid bone after denuding it of its epithelium, it will be necessary to make an opening by means of the mallet and chisel. For this purpose the spina suprameatum or spine of Henle should be carefully located and preserved during the subsequent procedures of the operation to serve as a land- mark. Some portion of the mastoid antrum will be found at a depth of from 12 to 22 mm. in a direction parallel to the meatus, immediately behind the spina suprameatum, in a 474 DISEASES OF THE NOSE, THROAT, AND EAR space called the mastoid fossa, the suprameatal triangle, or triangle of Macewen, which is bounded above by the linea temporalis, in front by the posterior wall of the meatus, and behind by the remains of the squamomastoid fissure of infants (Figs. 195, 197). If the latter landmark is not readily dis- cernible an imaginary line drawn from the parietal notch to the tip of the mastoid will answer the purpose. This line represents the course of the sigmoid sinus and in most temporal bones there is a decided bulging of the mastoid surface over it. If at a depth of 15 mm. or about y inch when chiseling through dense bone the antrum is not opened, the operator should pro- ceed with great caution to avoid injuring the facial canal or entering the cranial cavity, as the antrum may be small Fig. 212.-Stacke's protector. and easily overlooked. In some instances (Fig. 210) the lateral sinus is much further forward than usual, and to avoid injuring it the operator must keep as close to the meatus as possible. Where the drum-head and ossicles are partially destroyed, Stacke's protector (Fig. 212) or a silver probe with its tip bent at a right angle may be carried through the canal into the vault of the tympanum and held in such a position as to serve as a guide. If the chiseling and curetting be continued in the right direction within the triangle of Macewen, that is, from behind forward and from below upward, parallel to the canal and linea temporalis, there is little danger of wound- ing any important structure before the probe is encountered. When chiseling through sclerosed bones (Fig. 202), even though no cell structure or pus, but only softened bone in OPERATIONS UPON THE MIDDLE EAR 475 the region of the antrum is encountered, the relief of all mas- toid symptoms usually follows the operation. After-technic.-After the operation is completed, the wound and auditory meatus should be irrigated with warm sterile water and thoroughly cleaned. The wound may be allowed to fill with blood-clot or may be dressed by the open method. The former has the advantage of securing healing in ten days instead of the six weeks required by the other method, but is only applicable in cases where the operator is certain that he has secured an absolutely clean wound. The bone wound is allowed to fill with blood-clot. The upper and lower angles of the skin wound, including the periosteum, are carefully brought together with one or two sutures. A very small cigarette drain, made by inserting sterile gauze into a piece of catheter rubber which has been slit spirally, is then inserted superficially and held in place by a suture through the skin. Sterile gauze, cotton, and a roller bandage complete the dress- ing, which is not disturbed until the third or fourth day should the temperature remain normal. The cigarette drain is then removed and the dressing reapplied. Should the blood-clot become infected and break down, the sutures are removed, the wound cleansed with sublimate solution, and treated by the open method, which in a considerable proportion of cases is the preferable one from the start. After the mastoid wound and meatus have been cleansed as described above, they are filled with i : 2000 sublimate solu- tion and the wound packed loosely with iodoform gauze, one or two sutures being inserted at each angle of the wound if required and a roller bandage applied over sterilized gauze and cotton. If the temperature remains normal and the patient com- fortable after the operation the dressing should not be removed from the wound until the third day, after which the wound should be dressed every day or every other day. The parts should then be douched with a 1:5000 bichlorid solution, the wound again packed lightly with iodoform gauze, and sterilized 476 DISEASES OF THE NOSE, THROAT, AND EAR gauze, cotton, and roller bandage applied, especially in infants. If the wound be packed too firmly during the first few days following the operation there is danger of injuring the facial nerve, with resulting transient paralysis of some of the facial muscles; later on the wound may with advantage be packed more firmly. In some cases the wound does better if, after thoroughly cleansing, it be dusted with boric acid and packed either with sublimate or sterilized gauze. This is more es- pecially the case if the lips of the wound appear sluggish and the exposed bone does not quickly cover itself with granula- tions. The presence of edema in the superficial tissues about the wound may render advisable the use of a wet sublimate dressing for from twenty-four to forty-eight hours. Some- times exuberant granulations on the superficial edges of the wound will require removal with the curette or scissors, as the wound requires to be kept open until firmly healed from the bottom, a result that usually requires from three to six weeks. Usually recovery from a mastoid operation is uneventful. Pain and sleeplessness on the night following the operation may require the use of a small dose of chloral and bromid of sodium or even an opiate. Usually the temperature is practically normal and the patient entirely comfortable on the morning following the operation. If the evening tempera- ture for the first three or four days reaches ioo° or even ioi° F., it need occasion no anxiety. When the temperature re- mains normal for one or two days the patient may be allowed to sit up and move about in his room. Persistent pain and sleeplessness with high temperature following the operation may be due to a slight attack of local periostitis or to the fact that all the foci of inflammation in the mastoid bone have not been reached by the chisel. The former requires that the dressings be kept moist with a i: 3000 bichlorid solution for three or four days, the latter may necessitate a secondary operation. Accidents Occurring During the Mastoid Operation.-The middle cranial fossa or the posterior cranial fossa may be OPERATIONS UPON THE MIDDLE EAR 477 opened, and the lateral sinus exposed or wounded. One of the semicircular canals may be penetrated. The facial nerve may be wounded or divided. Occasionally the middle cranial fossa extends downward to a level scarcely more than | inch above the meatus. It is better, therefore, not to do any deep chiseling in this locality until the mastoid antrum has been located. After this has been accomplished and the cavity thoroughly exposed, it is easy to locate the exact position of the floor of the middle cranial fossa by means of a probe. After the antrum has been explored with the probe, it is easy, without the slightest danger of entering the middle cranial fossa, to remove the superficial bone, including the spina suprameatum above and behind the meatus, in order to secure a flat wound. Any considerable portion of the bony meatus itself should not be removed, as it is followed by collapse of the cartilaginous meatus after healing. However, if the middle cranial fossa be opened and the dura exposed, it is not a serious accident, as the dura granulates like the other portions of the wound. It is perfectly justifiable when softened bone is found in the vicinity of the tegmen to thoroughly remove the diseased bone even if by so doing the dura is exposed, as by this procedure a small ex- tradural abscess may be opened whose presence otherwise would not be suspected. Should pus be located between the skull and the dura, the opening in the bone should be made sufficiently large to secure ample drainage, but exploration with the probe between the bone and the dura should be under- taken with extreme caution and gentleness, because the dura ordinarily attaches itself about such an abscess-cavity to the skull, thus isolating the suppuration from the rest of the dural surface and preventing a general infection. If the dura is punctured, the opening should be enlarged with scissors to the extent of | inch to afford drainage and diminish the possibility of infection. Opening the Posterior Cranial Fossa and Wounding the Lateral Sinus During the Mastoid Operation.-In diploetic and small 478 DISEASES OF THE NOSE, THROAT, AND EAR compact mastoid bones the lateral sinus often occupies a position more anterior and superficial than is normally the case. In the bone shown in Fig. 210 a careless operator might readily expose and open the lateral sinus with the chisel. In very rare instances the sinus is not covered by bone at all, but lies immediately beneath the skin and might be freely opened by the first stroke of the knife. However, even in extreme cases of anterior position of the lateral sinus, there is usually a sufficient space of comparatively soft bone between the hard bone covering the sinus and that of the meatus for a careful operator to work through safely to the antrum with a curette or gouge. The position of the lateral sinus is often apparent after the cellular tissue has been curetted away, a distinct oval elevation of hard bone gradually shaping itself into view. This elevation is the hard bony wall of the sigmoid fossa in which the lateral sinus lies. Should the bone be carious and soft it should be scraped away with the curette and the sinus exposed, because extradural abscess is common in this locality. When the lateral sinus is torn or cut during a mastoid operation it does not spurt like an artery, but a gush of blood wells out from the wound, pulsating with each heart-beat as it flows. The lightest pressure of the finger upon the bleeding sinus causes the hemorrhage to cease. When the lateral sinus is accidentally wounded during a mastoid operation a small piece of iodoform gauze should be placed on the sinus and held in position by the finger of an assistant and, if possible, the operation completed. The wound should then be firmly packed with iodoform gauze in such a manner as to control the hemorrhage and a firm roller bandage applied. The dressing should not be disturbed unless absolutely necessary before the third or fourth day. At this time, if the packing over the sinus is slowly and gently removed, in all probability the hemorrhage will not reappear. Cases in which the lateral sinus has been accidentally wounded generally do well an make an uneventful recovery. However, it is wise during the first few days to keep such cases under OPERATIONS UPON THE MIDDLE EAR 479 careful observation lest the bandage be displaced and a hemorrhage recur. Opening the Horizontal Semicircular Canal and Wounding the Facial Nerve.-The position of the horizontal semicircular canal and the facial nerve is shown in Figs. 137, 138, 213, and 216. The aural portion of the facial nerve may be divided into a horizontal and vertical portion (Figs. 137, 138). The hori- zontal portion is embedded in a ridge of bone just above the oval window. The horizontal semicircular canal lies just above posteriorly. Both of these structures are embedded in ridges of extremely hard bone. These ridges can frequently be seen in the radical mastoid operation as soon as the attic is well exposed, and hence the exact position of the nerve located. The simple mastoid operation, even when it is suffi- ciently complete to convert the antrum into a shallow cup in the bottom of the bone wound, does not expose the bony ridges containing the horizontal semicircular canal and the horizontal portion of the facial nerve. However, these struc- tures lie so high up and so far forward that there is little danger of injuring them, except by a careless operator. Ordi- narily the ridges of bone containing the horizontal semicircular canal and the horizontal portion of the facial nerve are suffi- ciently hard and thick to offer great resistance to an instru- ment, but occasionally the bone is very thin over the horizontal part of the facial nerve or may in part be lacking, so that the nerve lies just beneath the mucous membrane. Hence, if at the close of a simple mastoid operation the aditus and attic are found to be full of exuberant granulations and the small curette (Fig. 189) is used to remove them, it should be em- ployed with great gentleness when scraping the inner median wall of the aditus. However, it is the vertical portion of the nerve that is most liable to injury during a mastoid operation. Because of the oblique position of the membrana tympani the annulus approaches in some instances as close to the nerve as | mm. at a position opposite the malleus tip. The operator should 480 DISEASES OF THE NOSE, THROAT, AND EAR observe considerable caution in removing much bone in this locality. When the bone forming the facial canal is necrosed it is difficult to avoid injuring the nerve during its removal, and hence, if the nerve is partially paralyzed before an operation, it is well to caution the patient that the operation may fail to relieve this condition or even make it worse. A simple bruising of the nerve during a mastoid operation is followed by transient paralysis of the muscles of one side of the face. The paralysis is usually worse in the muscles of the lower portion of the face because that part of the face is supplied by the more superficial fibers of the nerve. Cases of this kind and paralysis resulting from too tight packing of the mastoid wound end in complete recovery. If is stated that the nerve may be completely severed without causing permanent facial paralysis. The nerve also may be wounded at its exit from the stylomastoid canal which is at the anterior extremity of the digastric groove, posterior to the root of the styloid process, and immediately beneath the inner posterior wall of the ex- ternal meatus. If these facts are borne in mind, the position of the nerve at its exit from the skull is readily located with the finger after the removal of the mastoid tip. Radical Mastoid Operation, Exenteration of the Middle Ear.-So termed in contradistinction to the simple and complete mastoid operation also tympano-mastoid in con- tradistinction to the meato-mastoid or Heath operation. The object of the procedure is to convert the middle ear into a skin- lined cavity, all parts of which are visible and easily accessible for the removal of accumulations. After opening the antrum as in the simple mastoid operation the cartilaginous canal and as much of the periosteum as possible are separated from the bony canal by means of a small elevator. An incision is made through the loosened tissues as close to the drum-head as possible, and by traction forward upon the auricle the funnel-shaped mass is pulled out of the bony canal, exposing the tympanic structures OPERATIONS UPON THE MIDDLE EAR 481 clearly to view. A narrow strip of gauze is now passed through the cartilaginous canal from without inward and the ends tied together and handed to an assistant. The strip of gauze forms an efficient retractor for holding the canal and auricle forward out of the operator's way. The bone inter- vening between the meatus and the artificial opening is now chiseled away down to the annulus tympanicus. It should be borne in mind that the facial nerve approaches the annulus somewhat closely posteriorly on a level with the tip of the malleus handle, and the annulus should not be chiseled away below the level of the external semicircular canal. There yet remains the bony outer wall of the attic and aditus. This is weakened by chiseling with a narrow gouge the upper wall of the meatus until finally it is easily removed with a curette, the author's curette (Fig. 208) being convenient for this purpose. Its curved tip is introduced into the tympanum beneath the overhanging bone, which is rapidly cut away, not by drawing the instrument outward, but by rotating it in such a manner that the bone is cut alternately by the sharp anterior and posterior edges of the cup, the curved tip of the curette in the meanwhile preventing the instrument from becoming displaced. In order to afford a rirm grasp upon the instrument while executing this maneuver, the handle of the instrument between the cups is made very broad and rough- ened. The tendon of the stapedius muscle and the incudo- stapedial articulation are now severed and the malleus and incus removed. The curetting of the outer wall of the antrum and attic is continued until there is no overhanging wall of bone to prevent a clear view of the tegmen. It is important that no ridges of bone remain between the floor of the meatus and the mastoid wound. Such a ridge is conveniently chiseled away from behind forward with a gouge held at right angles to the axis of the canal; but the region of the facial nerve should not be incroached upon. The " hypotympanic space," or that portion of the tympanum below the level of the external bony meatus, is obliterated by cutting down the floor of the meatus 482 DISEASES OF THE NOSE, THROAT, AND EAR with a 4 mm .gouge. The tip of Stacke's protector .(Fig. 212) is f rst inserted into the hypotympanic space and held by an assistant. The operator then chisels away the bone toward the instrument being careful not to encroach on the posterior wall of the meatus and injure the facial nerve. The mucous membrane at the mouth of the Eustachian tube is also carefully rasped, or curetted away to secure obliteration of the tube mouth, which is accomplished by the growth of granulations during healing. However no amount of curetting which would be safe in the Eustachian tube will obliterate the tubal cells which are frequently present leading off into the bone. The position of the carotid canal should be borne in mind, as the use of cutting instruments at the tympanic tube mouth in a backward and downward direction is dangerous. The bony wound is flushed with cold bichlorid solution and firmly packed with iodoform gauze during the preparation of skin-flaps to check all oozing and permit of a thorough inspection of the tegmen and inner wall of the tympanum is search for necrosed bone or a fistulous opening leading into the cranial cavity or the labyrinth. Having exenterated the middle ear, a method is adopted for lining as much as possible of the large bone cavity with skin- flaps cut from the meatus and concha, to secure rapid epi- dermization and an enlarged meatus, to permit the free en- trance of air, and facilitate the drying and removal of debris after healing. It should be remembered that these flaps must consist only of skin, and, before cutting them, tissue and cartilage must be dissected from the posterior and upper part of the meatus down to the skin. An assistant inserts a hemostat into the cartilaginous meatus, which, when opened, stretches the meatus. The flesh and cartilage is then some- what easily removed with forceps and curved scissors. The skin of the meatus is now slit, by Pause's method, along its posterior surface to the concha, whence two right-angled in- cisions are made, one upward and the other downward, thus forming two quadrilateral flaps which are stitched to the OPERATIONS UPON THE MIDDLE EAR 483 periosteum and subcutaneous tissues with catgut in such a manner as to form a partial dermic lining for the middle-ear cavity and enlarge the meatus. Passow's modification of the Panse flaps is to make the incision >- shaped, so as to secure a short anterior flap which is bent sharply back and stretched into place after the meatus has been dilated by the operator's little finger. The uncovered space between these flaps may be allowed to heal by granulations or may be grafted at the time of the operation or ten days afterward by Thiersch's method. The wound behind the auricle is brought together by sutures through the periosteum and skin. A small cigarette drain is then placed loosely in the enlarged meatus and the parts protected by a dressing of gauze, absorbent cotton, and a roller bandage, in the same manner as after a simple mastoid opera- tion. If the temperature remain normal, the wound is not dressed for three or four days, after which daily dressings per- haps will be required. At each dressing the meatus is either syringed lightly with a x: 5000 bichlorid solution or simply mopped dry and a fresh cigarette drain inserted. Should the skin-flaps fail to grow or the wound becomes infected, exuber- ant granulations may require removal with scissors or snare and the instillation of alcohol. Epidermation is greatly hastened by applications of a 10 per cent, ointment of scarlet red. Kbrner's flap is made by two incisions, one at the postero- superior and the other at the postero-inferior border of the meatus, from its median aspect out to the concha; the resulting large quadrilateral flap is then reflected backward into the bone-cavity, partially lining it. Ballance's flaps are made by means of an incision which ex- tends from the median aspect of the meatus to the concha and then around the concha in the form of a shepherd's crook. The upper and lower flaps are secured by means of anchor sutures, two for the upper and one for the lower. Causes of Failure after the Radical Operation.-Failure may be due to the anomalous structure of the temporal bone where 484 DISEASES OF THE NOSE, THROAT, AND EAR the cellular structure leads to depths from which it is impru- dent to remove it; in some instances into the sphenoid and occipital. 2. Incomplete operation: generally failure to re- move the outer wall of the attic and antrum and completely open all cells. Epidermis grows with difficulty if at all over sharp edges of bone or into small cells with overhanging edges. 3. Failure to completely close the Eustachian tube: so that with each cold-muco-pressure is either blown or flows into the middle ear. 4. Retained secretions occasionally form choles- teatomatous masses which if long retained set up infection. 5. Neglect to watch the process of granulation and epider- mization; so that strictures of the canal result from thin walls of epidermis or pockets result from the bridging over of spaces by epidermis. 6. Insufficient space to permit free access to the mastoid cavity from the canal as the result of a faulty management of the skin flaps. The last word has probably not been said as regards the value of complete exenteration of the middle ear as a treat- ment of chronic otorrhea and the prevention of intracranial complications. It is urged that such complications do not occur except in a very small percentage of cases, and that chronic otorrhea not infrequently exists from early childhood during the entire life of the individual without greatly impair- ing his hearing or requiring more attention than somewhat frequent cleaning. That, on the other hand, besides the risk of complete exenteration, the patient's hearing, if good before the operation, will almost certainly be impaired to the extent of inability to hear the whispered voice at a greater distance than 1 meter, and may be practically entirely lost, and in a majority of cases, if epithelium and other debris are not removed every few months, there will be recurrent otorrhea. Therefore, it would seem wise, where there is a large perfora- tion of the drum-head and only the atrium affected, not to advise a radical operation, and in attic cases not until cleansing treatment faithfully carried out has failed to bring about a cure of the otorrhea. The operation is rarely justifiable in young 485 OPERATIONS UPON THE MIDDLE EAR Fig. 213.-Vertical frontal section through the skull, anterior portion of the specimen seen from behind. The saw has passed through the spina on the right side and laid open the aquaeductus Fallopii through its entire vertical portion, showing the facial nerve, under which a pin has been passed. It should be ob- served that the nerve lies nearly vertical in this part of its course, while above and external to it is an opening into the most external portion of the horizontal semi- circular canal. The anterior part of the antrum, A, has been opened, and also the vestibule, V, and the superior semicircular canal. On the left side the saw has passed through the posterior portion of the external and internal meatus, removing the posterior edge of the drum-head and the incus. . The stapes still retains its position in the oval window._ Below the tympanum is the bulb of the jugular vein. In comparing Fig. 213 with Fig. 214, note that the saw has passed slightly more anteriorly through the left ear of the specimen. (Author's specimen.) 486 DISEASES OF THE NOSE, THROAT, AND EAR children or on the ear of an adult upon which he mainly depends for hearing. Fig. 214.-Vertical section through the skull, posterior portion of the same specimen as Fig. 213. On the left side the saw has passed just anterior to the aquaeductus Fallopii, and.a pin has been passed under the facial nerve, N, at its exit from the stylomastoid foramen. Above is seen an opening made into the commencement of the vertical portion of the facial canal. Still higher up is a portion of the horizontal semicircular canal (H) laid open and occupying a posi- tion somewhat lateral to the facial nerve and median to the aditus (A). On the right side the section has passed through the anterior part of the antrum and is posterior to the facial canal, and has opened the horizontal semicircular canal at its most external part. (Author's specimen.) In order to overcome the disadvantages of exenteration, Heath has advised a semiradical operation similar to the ordinary operation, including the employment of skin-flaps OPERATIONS URON THE MIDDLE EAR 487 from the meatus and concha, which does not disturb the tympanic contents; on the thory that in most instances the Eustachian tube is able to drain the discharges of the attic and tympanum, but not also those from the mastoid cells. At the time of the operation the attic is thoroughly cleansed through the aditus by means of syringing and currents of air from the syringe, so that cholesteatomatous scales of epithelium Fig. 2is.-Vertical sagittal section through the tympanum; median aspect of the lateral portion of the specimen. The lower part of the membrana tympani is cut away by the saw and above the drum-head inclines outward at an angle of 140 degrees with the upper wall of the meatus. The malleus handle and the malleo-incudal articulation, as well as the descending process of the incus, are visible. The section passes through the canal for the tensor tympani muscle, so that the trochlea and tendon are shown. Above the tympanum portions of each of the semicircular canals are visible, (Author's specimen.) and even small pedunculated polypi are blown from the attic and appear in the canal, whence they are easily removed. Ultimately the aditus is closed posteriorly by cicatricial tissue after cessation of the otorrhea, without the impairment of hearing so common after a complete exenteration. In some cases regeneration of the drum-head occurs either wholly or partly. s When chiseling away the posterosuperior wall of the meatus and opening the attic, the topographic relation of the posterior wall of the meatus to the descending portion of the facial nerve 488 DISEASES OF THE NOSE, THROAT, AND EAR should be borne in mind. The student should study the topographic relation of the structures involved in operations upon the middle ear by preparing a large number of frontal, sagittal, and horizontal sections of the ear. Such sections should be made, not through a separated temporal bone, but while the bone is still in position in the skull. Injected heads, sawn in half through the sagittal structure and mummi- fied by exposure upon the roof of a house for a few months, Fig. 2 i6.-Posterior surface of the portion of the ear removed by the two ver- tical frontal saw-cuts seen in Fig. 215. The external bony meatus has been laid open only at its most external position. Above, the saw has passed through the aditus and posterior to the facial canal: A, Aditus, with its bony tocf partly re- moved; H, horizontal semicircular canal; M, meatus; N, facial nerve. are very suitable for making such sections. After the sections are made the parts should be freed from fat by repeated soak- ings in gasoline or benzine. By careful attention to this detail the specimens may be rendered almost devoid of smell, as the foul odor originates principally in the fat of the tissues. The specimens may be further cleansed and bleached by placing them in the sun and spraying them frcm time to time with an atomizer containing hydrogen peroxid rendered slightly alkaline by the addition of liquor potassae. After OPERATIONS UPON THE MIDDLE EAR 489 subsequent drying the soft parts should be preserved by ap- plying to them several coats of bleached shellac varnish, which may be made to assume any color required to render the structure more natural in appearance by the addition of one of the aniline dyes. Each coat of varnish is allowed to soak well into the soft tissues in order to preserve them. However, Fig. 217.-Horizontal section through the roof of the external meatus: I, Infe- rior portion; S, superior portion of the specimen; M, external auditory meatus: T, tympanum; M. A. mastoid antrum; A, carotid artery; L.S, lateral sinus; B, bulb of the jugular vein; N, facial nerve. In the lower half of the specimen is the handle and short process of the malleus, the saw having passed through the neck of the bonelet. The membrane slopes obliquely forward at an angle of 55 degrees with the axis of the meatus, and outward at an angle of 140 degrees with the roof of the meatus. The section passes through the oval window, so that the cavity of the vestibule (V), as well as the cochlea (C), is shown in the upper half of the specimen. _ Here also is to be seen the malleus head, the incus, the attic, and the mastoid antrum. The stapes has been removed by the saw. The bulb (B) of the jugular vein extends further upward than in most specimens. (Author's specimen.) specimens of a large section of the head prepared in this manner are rather too realistic to show indiscriminately to office patients, as by the skilful use of the aniline dyes they are made to look as if still bleeding and freshly severed from the body. Therefore, if it is found convenient to have a few specimens like Fig. 71, for example, to aid in the explanation to patients 490 DISEASES OE THE NOSE, THROAT, AND EAR a proposed operation, it is better to coat such specimens with aluminum or bronze paint. The most useful sections for purposes of study are a vertical, frontal section through the spina suprameatum (Fig. 216), a vertical sagittal section through the floor of the tympanum (Fig. 215), a horizontal section through the roof of the meatus (Fig. 217), and a section parallel to the inner wall of the tympanum (Figs. 136, 137, 138). Besides making the sections through the middle ear, the student would do well to operate many times upon the cadaver before attempting any serious operation upon the ear of a patient. INTRACRANIAL COMPLICATIONS OF OTIC DISEASE Intracranial complications of otic disease from acute sup- puration frequently are rapid and virulent. The infection may advance along the lymph-sheaths of vessels or nerves, in the blood-current, or from one of four points. The labyrinth, by way of the internal meatus, duct, or aqueduct, probably the most common route in septic leptomeningitis, or by infection through the thinnest layers of bone about the middle ear. These are the tegmen of the attic and antrum, the wall of the cells overlying the lateral sinus, and the floor of the tympanum. Extradural abscess, abscess of the temporal lobe, and men- ingitis originate by way of the tegmen. Extradural abscess, cerebellar abscess, sinus phlebitis, and meningitis by way of the cells about the lateral sinus; and infection of the jugular bulb through the tympanic floor. Intracranial complications occur in the following order of frequency: extradural abscess, sinus thrombosis, brain abscess, septic meningitis. Three- fourths of the infections occur in the posterior fossa and only one-fourth in the middle fossa. Theoretically the existence of an uncomplicated intracranial disease produces well-defined symptoms, but practically it is rare to have one portion of the intracranial contents infected without complicating others and rendering exact diagnosis as to the principal lesion often OPERATIONS UPON THE MIDDLE EAR 491 impossible. No single symptom is characteristic. Optic neuritis frequently occurs early in leptomeningitis and later in sinus thrombosis but may occur in purulent middle ear disease without obvious signs of an intracranial complication, and in this condition, vascular changes are so frequent as to amount to at least 25 per cent. There may be convulsions or exaggerated reflexes, as shown by Babinski's sign, which consists in extension of the great toe on touching the sole of the foot. Kernig's sign is probably the most constant, and stiffening of the muscles of the neck occurs in all inflamma- tions of the contents of the posterior fossa. Sensory symp- toms, photophobia, and hyperesthesia; sympathetic vaso- motor disturbances, the tache cerebrale, and finally symp- toms due to the death of nerve-cells, paralysis, anesthesia, and coma, may all be present in meningitis. The degree of purulence and the kind of bacteria in the cerebrospinal fluid obtained by lumbar puncture furnishes valuable informa- tion as to the extent and virulency of meningitis. When clear and sterile, only circumscribed inflammation is probable. Great purulency and streptococci or a mixed infection indicate a virulent diffuse meningitis, where operation would probably be useless, but slight turbidity and few bacteria do not indicate a hopeless condition. Lumbar puncture is performed as follows: The patient either sits up or lies upon the side, with the back arched and the knees flexed against the abdomen. The spine of the fourth lumbar vertebra should be located (a line drawn from one posterosuperior spine of the ilium to the other passes across it) and the puncture made | inch to one side, at the level of its lower end. The needle should be inclined at an angle of about 45 degrees to the surface of the skin, and should be thrust in a distance of from 2| to 3 inches. The most scrupulous asepsis must be observed. The spinal fluid flows readily, either in a stream when the pressure is high, or drop by drop if it is normal. In purulent meningitis it is cloudy and contains pus-cells; in tuberculous meningitis it is usually clear; in cerebral hemor- 492 DISEASES OF THE NOSE, THROAT, AND EAR rhage it may be bloody, but as admixed blood may be due to the injury of a vessel by a needle, the diagnosis should be made with caution. The quantity obtained varies from 2 to 3 to 80 or 90 ccm.-i. e., from a few drops to 3 fluidounces. Pressure symptoms, of which the most common is pain located in the frontal or occipital region, do not indicate the seat of the lesion. Vomiting in the initial stage is from septic absorption, but in the later stages results from pressure and is most common in cerebellar abscess. Restlessness, drowsiness, apathy, or moroseness, and in children intolerance of light are common. Pressure produces a slow pulse, and hence both in meningitis and abscess the pulse is rapid only in the initial stages. Localized symptoms, such as impairment of speech, muscular atony, and cerebellar ataxia occur when certain areas are involved and may be the result of pressure, inflammation, or actual destruction of the part. Kemig's Sign.-In 1884 Kernig announced the impossibility of producing complete extension of the leg on the thigh, with the patient sitting and the thigh flexed at right angles to the trunk, when there is irritation of the meninges of the lower portion of the cord. In bedfast patients the thigh should be flexed on the abdomen, and if meningitis be present, complete extension of the leg will be prevented by contraction of the flexor muscles. Kernig's sign may be present in any form of meningitis, but its absence does not exclude localized meningitis. Examination of the blood in intracranial complications of mastoiditis may render valuable assistance. The blood is composed of fluid and corpuscular portions. The fluid portion is called the liquor sanguinis or plasma and yields on evaporation about 10 per cent, of solid matter, consisting of fibrinogen, serum, albumin, serum albumin, serum globin, and salts, mostly sodium chlorid. The corpuscular elements con- sists of red cells or erythrocytes, white cells or leukocytes, blood-plaques, and hemoconia or blood dust. The chief function of the red corpuscles is to carry oxygen OPERATIONS UPON THE MIDDLE EAR 493 from the lungs to the tissues. In health their number varies from 4,500,000 to 5,000,000 to the cubic millimeter, and the percentage of their chief component, hemoglobin, from 85 to 95 per cent. A decided diminution in the number of red cells or in the percentage of hemoglobin in sepsis is propor- tionate to the virulence and duration of the infection. In simple anemia, where the proportion of hemoglobin is below 50 per cent., it is better to delay operations when possible until systemic treatment has corrected the deficiency. The normal coagulation time of blood, as tested by the glass slide or Wright's coagulatometer, is from two to five minutes. In patients suffering from jaundice, hemophilia, or purpura, if coagulation does not occur in ten or fifteen minutes, it is best to avoid operations when possible until systemic treat- ment has brought about the normal coagulability of the blood in order to avoid troublesome hemorrhage. This can be accomplished in most instances by the administration of 5 gr. of calcium chlorid (Formula 47) every three hours for one or two days, or the injection of horse serum. Blood-plaques are small spheric bodies whose function is but imperfectly understood, but they are supposed to play an important part in the formation of a clot. In health they number from 108,000 to 500,000 to the cubic millimeter. Hemoconise are small highly refractive bodies constantly present, about whose origin and function nothing definite is known. Bacteriemia, or the presence of specific bacteria in the blood, is conclusive evidence of the nature of an infection, and it is possible to secure sometimes a nearly pure culture of the offending organism. According to some authorities the pres- ence in the blood of the staphylococcus pyogenes albus does not affect the prognosis, but the prognosis is grave when any other pyogenic bacteria are present. Positive results from blood culture tests are said to be only found in otic cases when complicated by meningitis or sinus thrombosis, and the method is especially valuable when there is doubt as to the 494 DISEASES OF THE NOSE, THROAT, AND EAR existence of a sinus thrombosis after a mastoid operation when the temperature remains high. Leukocytes are of three groups depending upon the stain- ing qualities of the granules within the cystoplasm: eosinophiles stain best with acid aniline dyes; basophiles with basic dyes and neutrophiles with neutral dyes. There are two varieties of leukocytes: I. Lymphocytes large and small with- out granules in the cell and without ameboid movements; II. leukocytes with granular cytoplasm and ameboid move- ments. There are mononuclear leukocytes, a transition form between lymphocytes and polymorphonuclear leukocytes, polymorphonuclear leukocytes and eosinophiles. Leukocytes, by their bactericidal or phagocytic action, pro- tect the system from infection and assist the elimination of the products of inflammation, irritation, and tissue metamorphosis. In health their number varies from 5000 to 10,000 to the cubic millimeter. DaCosta states the proportion of the different leukocytes as follows: Variety Per Cent. Number per Cubic Millimeter Small lymphocytes 20-30 1000-3000 Large lymphocytes and transitional forms 4-8 200- 800 Polynuclear neutrophiles 60-75 3000-7500 Eosinop hiles o.5-5 25- 500 Basophiles 0.5 25 85-118 4250-11800 Leukocytosis is an increase in the proportion of white cells, generally as the result of an increase in the number of poly- nuclear neutrophiles. Pus may be suspected when the per- centage is over 75 per cent., but a lower percentage does not contraindicate a mastoid operation when clinical symptoms are present because the percentage indicates only the amount of toxins being absorbed. Sometimes all the varieties of leukocytes are increased in number. In health various causes may produce a temporary leukocytosis up to 10,000. Leu- kocytosis is said to be mild when the number of leukocytes is OPERATIONS UPON THE MIDDLE EAR 495 not above 16,000, and well marked when their number reaches 20,000 or 25,000. The grade of leukocytosis indicates the vigor of resistance to infection. Generally a mild infection with good resistance results in moderate leukocytosis and a virulent infection in well-marked leukocytosis; but if the infection is so severe as to overwhelm the patient's powers of resistance, there will be a decrease (leukopenial) in the percentage of white cells. These facts have an important bearing on the prognosis in the intracranial complications of mastoiditis, because if there is a decided leukocytosis present, it indicates that the resist- ance of the patient to the bacteria causing the infection is active, while a decided leukopenia indicates feeble resistance and an unfavorable operative prognosis. However, it should be borne in mind that bacterial infection does not produce leukocytosis unless the toxins resulting enter the blood in sufficient amount to exert a chemotactic action on the leu- kocytes, and the blood-count is usually negative in chronic pus cavities. Hence, in uncomplicated tuberculosis of the ear or upper respiratory tract, there usually is no leukocytosis present. For the same reason, in malignant disease there may be no leukocytosis, or it may be present to the extent of 30,000 or even 40,000, but in septicemia from any cause the leukocytosis is not usually above 20,000. In leptomeningitis and sinus thrombosis there is usually either high leukocytosis or leukopenia. Serous leptomeningitis begins as a general hyperemia of the pia and arachnoid, followed by a serous exudation. The dura and ventricles become distended by the exudate with resulting pressure symptoms. Slight cerebral irritation, especially in children, probably meningitis, frequently accompanies acute inflammation of the middle ear. The symptoms are localized headache referred to the temporal or occipital region, which may be tender on palpation. Morning and evening fever is sometimes present and, in infants, convulsions. These symptoms may disappear 496 DISEASES OF THE NOSE, THROAT, AND EAR within a short time as the result of purgation with calomel, the use of bromid of potash, and an ice-cap, or the pulse may become rapid, the temperature rise, the pupils cease to react to light, and hebetude with loss of consciousness occur. Under such circumstances immediate relief frequently follows lumbar puncture. An ounce or more of cerebrospinal fluid some- times quickly flows from the cannula and pressure symptoms subside. Especially in children grave intracranial symptoms sometimes disappear within a few hours after the evacuation of pus from the mastoid antrum. Lumbar puncture may be repeated as often as necessary to afford relief, and the cerebro- spinal fluid can, if clear and apparently normal, be carefully examined for the presence of bacteria. Sometimes a latent tubercular meningitis is fanned into fierce activity by the irritation of a simple acute otitis media. Subdural or Extradural Abscess.-It is an inflammation of the dura mater, also called external meningitis and perimen- ingitis. Generally it is the result of infection from caries. Fortunately, under such circumstances the dura generally forms adhesions around the carious area of bone and thus prevents the spread of the infection. The disease then becomes a subdural abscess. The infection may remain quiescent or the dura may be penetrated with resulting lepto- meningitis or inflammation of the pia and arachnoid. Here again adhesions may prevent the spread of the infection with a resulting localized meningitis, involving also perhaps a super- ficial portion of the brain, or sooner or later the white matter of the brain, and the formation of one or more abscesses. The usual sites of subdural abscess following aural suppura- tion are the groove for the lateral sinus and the superior surface of the petrous bone. Such collections of pus can sometimes be located and evacuated by surgical intervention. Cases of spontaneous evacuation through the middle ear have been reported. It is not very unusual during a mastoid operation to open such an abscess when removing carious bone with a curette. OPERATIONS UPON THE MIDDLE EAR 497 When the dura is thus exposed a probe should be used with great gentleness in order not to break up any adhesions that have formed between the dura and bone about the abscess- cavity. At the same time the amount of bone removed should be sufficient to permit ample drainage from the infected dural surface, which is usually covered by granulations and Fig. 218.-Left temporal bone, showing dura mater of cerebrum and cere- bellum, the lateral sinus, the tympanic membrane, and the interior of the mastoid antrum. The anterior wall of the auditory meatus has been removed: I, Dura mater; 2, middle meningeal artery; 3, lateral sinus; 4, mastoid emissary. (Bruhl and Politzer.) See Fig. 211. which should not be disturbed, as they prevent the spreading infection. Abscesses of the cerebrum or cerebellum following otitis are probably invariably located on the affected side. They may be single or multiple, frequently small and connected by tiny canals. It is the white substance that is generally involved 498 DISEASES OF THE NOSE, THROAT, AND EAR and there can be a considerable thickness of sound tissue between the abscess and the cortex. The bacteria found in the pus are various, generally those found in the discharges of the ear that has been the cause of the infection. The disease is generally the result of chronic purulent otitis. The entire brain may be inflamed (diffuse encephalitis) or the inflammation may be localized about the abscess (localized en- cephalitis). A labile pupil and paralysis of the third nerve on the same side as the abscess, is of diagnostic importance. Symptoms.-'Cerebral abscess may present no symptoms for many months, but at any moment acute meningitis may occur or increased intracranial pressure result in coma and death. If the abscess is acute, absorption is sufficient to produce a high polynuclear count, but if long standing and encapsulated there may be no leukocytosis and the symptoms so ill defined that the abscess is only found accidentally during a mastoid operation as the result of a telltale fistulous opening. The dura when exposed should be examined for discolora- tions and lack of pulsation, which, however, may not be present if the abscess is small and deep seated. When symp- toms of abscess are not marked it is customary to await the result of a mastoid operation before exploring the brain. When the abscess is large, pressure symptoms appear, with, possibly, optic neuritis and papillary phenomena. There is headache, mental depression and loss of weight and vomiting as a late symptom. When the left temporal lobe is involved, either by the pressure or inflammation, there may be disturbances of speech; when motor areas are affected, muscular symptoms; and when the abscess is located in the cerebellum, cerebellar ataxia with weakness of the hand grasp and rigidity of the muscles of the neck. In chronic cases there may suddenly occur a chill followed by a septic temperature, high leukocyto- sis, and polymorphonuclear percentage and a cerebrospinal fluid free from pus. The pulse becomes slow, there is cachexia and increasing mental dulness, ending in coma and death. OPERATIONS UPON THE MIDDLE EAR 499 The symptoms of cerebellar abscess are more obscure even than in cerebral abscess and the diagnosis extremely difficult. Subjects of cerebellar abscess may present absolutely no symptoms, and yet suddenly die as the result of the rupture of the abscess into the fourth ventricle. Nystagmus is present in cerebellar abscess and suppuration of the labyrinth (p. 520). It becomes more apparent as the disease progresses in cerebellar abscess; weaker in progressive suppuration of the labyrinth. Treatment.-Surgical intervention in all cases of intracranial suppuration is the only adequate remedy. As a general rule the cranial cavity should only be entered after removing diseased structures from the middle ear. After the antrum and attic have been cleansed, the original skin-wound is enlarged to a sufficient degree by an incision directly backward toward the occipital protuberance if the posterior fossa is to be ex- plored, or directly upward from the anterior point of the mas- toid wound if the middle fossa of the skull is to be opened. If the symptoms indicate the posterior fossa as the probable seat of the lesion, the groove for the lateral sinus is then opened and the sinus examined carefully for thrombus. If it is normal in appearance or covered by healthy granulations, more dura is exposed medianly by the removal of the mastoid bone from "Troutman's triangle," which is a space with its anterior angle at the prominence containing the labyrinth, bounded behind by the lateral sinus and above by the linea temporalis. At the upper posterior angle of this triangle, when the bone is removed, the superior petrosal sinus (Fig. 217) will be encountered and should be examined carefully for thrombus, which sometimes occludes this vessel without extending into the lateral sinus. While proceeding with the operation it is possible that an extradural abscess may be opened. Under such circumstances free drainage should be secured and the wound dressed. If no such collection of pus is discovered while enlarging the cranial opening, a flexible grooved director should be passed in different directions 500 DISEASES OF THE NOSE, THROAT, AND EAR between the dura and the skull in search of pus, and finally the tegmen of the antrum and attic removed, as an extradural abscess is not infrequently located upon this thin plate of bone. If an abscess of considerable size be present near the dura, it will bulge without pulsation into the wound. The dura should be incised for a distance of about i inch, and a brain explorer forceps with separable arms inserted carefully into the brain. Should pus escape or the instrument yield a fetid odor when withdrawn, the wound should be carefully enlarged sufficiently to allow the pus to escape and the abscess-cav- ity gently washed out with a sterilized saturated boric acid solution. A strip of gauze is then inserted and the wound dressed. It is probably safer to wash out the abscess-cavity each day with boric acid solution. Whiting has devised an instrument which he calls an encephaloscope, through which the interior of the abscess-cavity can be inspected, irrigated, and a drain inserted without bruising the normal brain tissue. If no pus follow the insertion of the brain explorer into the brain, it may be inserted at another place or in another direc- tion, with due regard for the anatomy of the parts. When searching for an abscess in the temporal lobe the explorer cannot be inserted for a distance over 4 cm. (r-| inches) without endangering the lateral ventricles. While most operators find the mallet and chisel and heavy forceps like those of Keen sufficient for removal of bone for the exploration of the anterior and posterior fossa, yet a tre- phine can sometimes be used to advantage. One of at least f inch should be employed. For epidural abscess the center pin of the trephine should be placed upon the skull 1 inch above the center of the meatus. The resulting opening in the skull, if sufficiently enlarged with the rongeur forceps, will enable the operator to explore the surface of the tegmen of the atrium and tympanum. The posterior cranial cavity may be explored by a trephine opening if the center pin of the instru- ment be placed i| inches behind the center of the meatus and | inch below Reid's base line. Both the middle and the OPERATIONS UPON THE MIDDLE EAR 501 posterior cranial cavities can be explored by means of a trephine opening if the center pin of the instrument be placed ij inches behind the center of the meatus and i| inches above Reid's base line. As the skull in this position is compara- tively thin, it is easy from such a trephine opening with the rongeur forceps to tear away the skull either downward into the posterior fossa or forward into the middle fossa. Purulent Leptomeningitis.-In purulent meningitis the exudate becomes cloudy and mucopurulent in appearance from the presence of leukocytes. The bacteria present vary and are usually those found in the otorrhea that has caused the condition. Pathology.-The vessels of the pia and arachnoid are in- fected and the membranes become cloudy. A serofibrinous or purulent exudate distends the dura or may exist only in patches. The cerebral membranes may be involved either as a whole or in part. In severe cases those of the spine are affected as well. The brain or cord may be softened in places or, as Anders states, no gross lesions, either of meninges, brain, or cord, even microscopic, are found postmortem in many cases presenting the clinical picture of meningitis. Symptoms.-The temperature is usually from ioi° to 1050 F., and exhibits but slight variation during the day and night. There are severe headache, photophobia, vomiting, and localized or general convulsions. Delirium is common in young subjects, but in adults the patient is at first wakeful, but slowly passes into a condition of fatal coma. Paralysis of the pupil, strabismus, and ptosis are the most frequent forms of paralysis present. There is often retraction and fixation of the head. Reflexes are at first increased and later diminished or absent. There is hyperesthesia of the skin. The pulse, at first full and rapid, later in the disease is slow, but becomes again rapid in the last stage. Koenig's and Babinski's signs are usually both present, and a finger drawn across the skin produces a red mark which persists for a time ("tache cerebrate"). The pupils finally 502 DISEASES OF THE NOSE, THROAT, AND EAR become dilated. There is general paralysis and death, occur- ring as early as two or three days or postponed for some weeks. Diagnosis.-True leptomeningitis differs from serous menin- gitis with symptoms of "meningeal irritation" or meningismus in that it generally starts with great suddenness a considerable time after the onset of the aural suppuration that produced it, and may exist without symptoms of mastoiditis and runs its course with increasing rapidity of symptoms, and is somewhat rare in infants among whom meningeal irritation and serous meningitis is far more common. Treatment.-Where the symptoms are simply those of cere- bral irritation, perfect rest in bed, large doses of the bromids, purgation with small, frequently repeated doses of calomel, and salines are sometimes sufficient to check the attack. An ice-bag should be applied to the head. In some cases urotropin (Formula 93) undoubtedly does good and may be administered in five-grain doses every two to three hours by the mouth; with colonic irrigation by the Murphy method with warm normal salt solution. Where lumbar puncture gives relief, it should be repeated as often as necessary. The procedure is of value not only as a method of treatment, but as a matter of diagnosis. The amount of fluid flowing freely through the needle indicates the degree of pressure, and the microscope will disclose the presence of pus and the bacteria causing the infection. Great cloudi- ness from pus and numerous virulent bacteria indicate an almost inevitable fatal termination by any known treatment. For this reason surgical measures, to be of value, must be instituted before general infection of the meninges has occurred. A mastoid operation should be done before or at least as soon as intracranial symptoms appear. This may be sufficient, especially in children, to cause a speedy subsidence of menin- geal symptoms. Should this not occur, the cranial cavity should be opened in search of abscess or sinus phlebitis, and if neither are present, the dura should be incised in one or more OPERATIONS UPON THE MIDDLE EAR 503 places to permit leakage of cerebrospinal fluid. Opening of the cisterna magna through a trephine opening at the base of skull allows of continuous drainage of cerebrospinal fluid and relief of pressure symptoms. In addition, 30 to 60 gr. of urotropin a day may be given or the injection of antistrep- tococcus serum tried. Sinus Thrombosis.-The lateral sinus may be infected by way of the superior petrosal sinus as the result of attic suppura- tion or, especially in children, the bulb of the jugular vein may be infected through the floor of the tympanum. Usually, however, the infection proceeds from the mastoid cells by the numerous small veins that reach the sinus through the bone. An early stage of the process is the occlusion of the sinus by a firm fibrinous clot which may extend backward as far as the torcular Herophili or downward into the internal jugular vein. The development of septic bacteria within the clot leads to general septic infection; and if the patient survives long enough, secondary abscesses appear in various organs of the body, septic pneumonia being the most common complication; but it should not be forgotten that sinus thrombosis may produce secondary sinus thrombosis and brain abscess on the opposite side. Occasionally sinus phlebitis occurs as the result of the contact of necrosed bone, so that the sinus is easily torn during the mastoid operation, with resulting severe hemorrhage. The process begins as a phlebitis with swelling of the sinus walls sufficient to cause slowing of the blood current and the formation of an adherent clot which, however, never extends further than the inflammation of the vessel walls. At any part of the thickened and inflamed sinus the swelling may be so great as to completely obliterate its lumen, and if at an operation the walls of the jugular are found collapsed a clot may exist lower down toward the heart, but if the vessel walls are healthy no such clot can exist and it is useless to look for it. Ballenger states that, at the beginning the thrombus is not infected. It is only after the wall of the membranous sinus has undergone marked deterioration that the infective micro- 504 DISEASES OF THE NOSE, THROAT, AND EAR organisms penetrate it and lodge in the thrombus. That is, if the condition were diagnosticated before infection, it would be prevented by the removal of the diseased bone without opening the sinus. Symptoms.-In typic cases the temperature abruptly rises to 1040 or even 1060 F., and as quickly falls to normal or even subnormal. There may be only one rise in temperature during twenty-four hours, or several, depending upon the rapidity and quantity of toxin entering the system. In about 50 per cent, of cases the sudden rise in temperature is preceded by profuse sweating. The pulse corresponds with the tempera- ture and may reach 150; but where the phlebitis is complicated by meningitis, usually it is much slower. During the period of high temperature the respirations may reach 40 or 50 a minute, especially in children. Nausea and vomiting are usually present at some stage of the disease. Patients are frequently drowsy, but when aroused answer questions rationally, and usually there are no symptoms of impaired cerebration in the earlier stages of the disease. The face is anxious, the skin is dry, and in the later stages of a yellowish hue, denoting sepsis. There is loss of appetite,afoul tongue, and fetid breath. There may be edema of the mastoid in the region of its vein and marked stiffness of the muscles of the neck, the face being drawn toward the affected side. In the later stages the inflamed jugular may sometimes be felt as a cord-like swelling at the anterior border of the sternocleido- mastoid muscle. Optic neuritis occurs in less than one-third of the cases and is not followed by atrophy. Atypic cases are those following a mastoid operation when the patient does well only for a few days. The tongue becomes coated and there is a gradual rise in the temperature to 1030 or even 1050 F., remaining so for several days without sudden elevations and depressions. There is intense headache and inability to sleep, and if surgical measures are not adopted, pyemic symptoms develop. On inspection, the mastoid wound will be found granulating OPERATIONS UPON THE MIDDLE EAR 505 normally except at a point over the sinus, where the bone will appear darker than when exposed during the operation. If the sinus was uncovered at the operation, it will be seen devoid of granulations, gray, and easily compressible. When the bulb of the jugular vein is primarily affected from the tympanic cavity in the early stages of acute purulent otitis, the symptoms are those of that disease in an aggravated form. There is, however, sudden rise in temperature to 1040 F. or above, and sudden remissions to 990 or ioo° F. In doubtful Posterior belly of digas- tric muscle Spinal accessory nerve Occipital artery Stylohyoid muscle Facial vein Hypoglossal nerve Descendens hypoglossi nerve Lingual vein Sternocleidomastoid mus- cle Superior thyroid vein Anterior belly of omo- hyoid muscle Communicantes hypo- glossi nerves Sternothyroid muscle Common carotid artery Phrenic nerve Sternohyoid muscle Middle thyroid vein Fig. 219.-Exposure of the internal jugular vein, etc.; the vein is about ready for removal (Allport). cases a blood-culture, showing the presence of streptococci, and a high or low leukocytosis and high polymorphonuclear per- centage, renders the diagnosis more than probable. During the temperature remissions the patients, who are usually young children, feel remarkably well and ask to sit up and play with their toys, so that the uninitiated may be led to think that there is a decided improvement in the patient's condition until another sudden rise in temperature dipels any doubt as to the nature of the infection. 506 DISEASES OF THE NOSE, THROAT, AND EAR Prognosis.-A certain number of cases of primary thrombosis recover spontaneously, although it is impossible to state how many die subsequently of secondary cerebral abscess and other sequelae of the disease. Without operation sinus phlebitis is usually fatal. The diagnosis is usually easy in a typic case. When during the mastoid operation the sinus is uncovered as the result of the removal of carious bone, there is usually an epidural collection of pus. When this is removed the sinus wall may appear thicker than normal and darker in color. It may be lusterless and of a dirty white or covered with an exudate or granulations. The sinus may be flatter than normal and when pressed upon does not quickly refill as soon as the pressure is released. However, without the characteristic temperature chart, these appearances are not sufficient to warrant opening the sinus. In io cases of thrombosis in the Mt. Sinai Hospital, New York, cultures of blood from the median vein were positive in 7 cases; in 5 cases streptococcus pyogenes, one case strepto- coccus mucosa, one case Bacillus proteus. A differential blood- count showing a polynuclear percentage of over 80 indicates an nfective process that almost certainly demands surgical in- tervention. The amount of leukocytosis indicates the pati- ent's resistance to the disease. Treatment.-Early operation if the diagnosis is certain. The only therapeutic measures of value are those which combat the asthenia. Nutritious food, two or three grains of quinin every three hours with one or two ounces of whiskey and colonic irrigation with normal salt solution by the drop method. More than one-half pint of whiskey or ten or twelve grains of quinin per day usually causes so much gastric irritation that larger doses are unadvisable. When the mastoid antrum has been previously opened, the original opening should be enlarged backward and down- ward, and the sinus exposed from a point above its downward bend or "knee" to a point as near the jugular bulb as possible, OPERATIONS UPON THE MIDDLE EAR 507 but too much bone should not be removed so as to uncover a large dural area over the cerebellum, as hernias are more liable to occur at this point than in other regions of the brain. The partial notch is over the knee of the sinus which at this point receives the blood from the superior petrosal sinus (Figs. 218-220) at the most posterior lateral corner of the floor of the middle fossa of the skull. A line from the parietal notch to the tip of the mastoid will indicate the course of the sigmoid portion of the sinus from the knee to the jugular bulb, and a line from the notch to the occipital protuberance, the course of the sinus toward the torcular Herophili. After the sinus has been uncovered, a small piece of iodoform gauze should be rolled up and inserted between the sinus and the bone at the upper angle of the wound, in such a manner as to cut off the circulation in the vessel should it be present. A similar piece of gauze should also be inserted at the lower angle of the wound between the bone and sinus. The head of the operating table should be lowered, the wound filled with sterile water and the sinus between the pledgets of gauze laid freely open and the contents of the vessel evacuated. If, after re- moving the upper piece of gauze, blood does not freely flow from the distal end of the sinus, the vessel should be further exposed toward the torcular by the removal of the overlying bone and laid open to the torcular unless a free hemorrhage is encountered before that point has been reached, as it is important that the septic clot should be removed from this region to prevent a further spread of the infection. When the pledget of iodoform gauze is removed from the lower portion of the wound, a free hemorrhage through the sinus from the bulb is sometimes encountered. It is impos- sible to determine whether this comes from the internal jugu- lar or from the inferior petrosal; but it is customary under such circumstances, if the clot removed from the sinus was firm, to desist from further operative procedures, pack the sinus with gauze, and await developments. However, if instead of a firm clot the sinus contents consist of disintegrated 508 DISEASES OF THE NOSE, THROAT, AND EAR Fig. 220.-Base of skull; left labyrinth exposed on the right side; the grooves in the base of the skull are shown; the sinuses of the dura mater are marked in black (two-thirds life size): I, Crista frontalis (on the left, beginning of the supe- rior longitudinal sinus); 2, foramen cecum (emissarium Santorini); 3, crista galli; 4, lamina cribrosa (olfactory nerve); 5, lesser wing of sphenoid; 6, optic foramen (optic nerve, ophthalmic artery); 7, anterior clinoid process; 8, sella turcica, flanked by the median clinoid process; 9, dorsum ephippii, with posterior clinoid process; 10, foramen rotundum (second division of fifth nerve); 11, foramen ovale (third division of fifth nerve); 12, foramen spinosum (middle meningeal artery and. recurrent branch of fifth nerve); 13, carotid canal and foramen lace- rum anterius (great and lesser superficial petrosal nerves, Eustachian tube, and tensor tympani muscles); 14, anterosuperior surface of pyramid; 15, cochlea; 16, semicircular canals; 17, tegmen tympani and roof of antrum laid open; 18, anterior. condyloid foramen (twelfth nerve); 19, posterior condyloid foramen (emissarium_ Santorini); 20, foramen magnum; 21, superior petrosal sinus; 22, transverse sinus (descending portion); 23, transverse sinus (horizontal portion); 24, superior longitudinal sinus and torcular Herophili (confluence of the sinuses); 25, occipital sinus; 26, occipital sinus; 27, vein of aqueduct us vestibuli (emerging at the external aperture of aquasductus vestibuli); 28, internal auditory vein emerging in the internal auditory meatus); 29, vein of aquaeductus cochleae (emerging at the external aperture of aquaeductus cochleae); 30, inferior petrosal sinus emptying into the cavernous sinus; 31, circular sinus (Ridley); 32, groove traversing anterior fossa of skull; 33, sinus of lesser wing of sphenoid; 34, groove for meningeal artery; 35, transverse groove through middle fossa of the skull; 36, longitudinal groove through petrous portion of temporal bone (tegmen tym- pani); 37, groove through apex of pyramid; 38, transverse fissure (between pos- terior condyloid foramen and foramen magnum); 39, longitudinal groove through posterior fossa of skull; 40, impressio carotica (corresponding to the bend in the internal carotid artery); 41, juga cerebralia and impressiones digitatae (Bruhl and Politzer), OPERATIONS UPON THE MIDDLE EAR 509 clot and pus, further manipulation should be suspended until the internal jugular has been ligated as low down in the neck as possible. The line of the internal jugular vein is from the tip of the mastoid to the intraclavicular notch. The patient is placed in the tracheotomy position with a sand-pillow under the shoulders and the face turned toward the opposite side. An incision is made along the anterior border of the sterno- cleidomastoid muscle and the vein exposed by dry dissection. The wound should not be held open as in Fig. 219, because this procedure interferes greatly with easily finding the vein, which lies immediately beneath the anterior border of the muscle to the outer side of the carotid with the pneumogastric nerve behind both vessels. A double ligature is applied to the vein as low down as possible and the vein severed between the ligatures. The vein should then be resected upward to its exit from the skull. All diseased lymphatics encountered during this procedure should be removed, and tributary branches ligated as far away from the vein as possible. These consist of the middle and superior thyroid, the lingual and facial veins and all enter the jugular at its median border. After this has been done the contents of the sinus above should be evacuated. Under these circumstances there will be a free hemorrhage through the bulb from the inferior petrosal sinus. Should this not occur, as fortunately is rarely the case, it indicates that the inferior petrosal sinus is obstructed, and should the patient's condition permit, this sinus and the superior, if necessary, should be exposed and emptied of their contents. The wound in the neck may be treated by the open method, the skin subsequently being drawn together by adhesive strips, or a cigarette drain may be inserted and the skin sutured. Facial paralysis, or Bell's palsy, is a paralysis or paresis of some or all of the muscles supplied by the facial nerve. In the graver form of the disease there is complete immobility of the muscles of expression of the affected side of the face, slight deafness from involvement of the stapedius muscle, unilateral 510 DISEASES OF THE NOSE, THROAT, AND EAR paralysis of the uvula and the palate, and unilateral impair- ment of the sense of taste at the anterior two-thirds of the tongue, through involvement of the chorda tympani nerve. Etiology.-The disease may be central, as the result of basilar meningitis, tumors or exostoses at the base of the brain, syphilitic lesions in this situation, or aneurysm of the vessels at the base of the brain. Not a few cases are apparently rheu- matic and result from exposing one side of the face to a draft, sitting in a damp room, or suddenly chilling the body when overheated. This disease is of interest to the aurist chiefly from the fact that it may occur as a complication in a large variety of middle-ear affections, or as a result of the nerve being bruised or wounded during the course of an operation upon the middle ear, or from packing the wound too tightly after the operation. It should be borne in mind that the facial canal arches backward over the oval window and then descends almost perpendicularly through the temporal bone. As the result of the oblique position of the drum-head the facial canal approaches in some skulls to within i millimeter of the annulus, at a position about midway between the floor and the roof of the canal. The pressure of a polypus or an accumulation of epithelium or cerumen on the nerve through the thin bone of this region is sufficient in some cases to produce paralysis of the facial nerve, usually remediable by the removal of the offending body. Generally, however, the facial nerve in its passage through the middle ear is defended by compara- tively thick and hard bone. In some instances, however, the bone covering the nerve above the oval window is as thin as tissue-paper, and congenital dehiscence of the bone of this region are by no means uncommon, so that the nerve in such cases lies almost immediately under the mucous membrane. Such a congenital lack of bone in this position explains the occasional occurrence of facial paralysis as the result of simple non-suppurative catarrh of the middle ear. Suppuration of the middle ear is a common cause of facial paralysis, some- times so slight that the lack of mobility of the affected side of OPERATIONS UPON THE MIDDLE EAR 511 the face can be detected only by the closest scrutiny; at other times the paralysis is complete and involves all the muscles supplied by the facial nerve on the affected side of the face. Such cases are doubtless the result of pressure on the nerve caused by spreading of the inflammation from the mucous membrane to the bony wall of the facial canal and the sheath of the nerve, and are the more favorable instances of the disease; for after the subsidence of the inflammation and the absorption of the exudation the facial paralysis disappears spontaneously. F acial paralysis occurs during caries and necrosis of the temporal bone if the inflammation and destruc- tion extend to the nerve; but caries of the facial canal is not always accompanied by paralysis, for the nerve has been exposed and bathed in pus for months without the occurrence of facial paralysis. Facial paralysis in more than one instance has followed the simple removal of the drum-head and larger ossicles, and is not uncommon as the result of the mastoid operation. Most of these cases ultimately completely recover, sometimes even when there was reason to suppose that the nerve had been completely severed. When working in the neighborhood of the facial nerve some operators direct their assistant to watch for slight twitching of the muscles of the face, and desist immediately should this occur. Symptoms.-Double facial paralysis is somewhat rare. When it does occur and is complete, the face is absolutely ex- pressionless and as immobile as that of a graven image. Facial paralysis sometimes appears quite suddenly, but in many instances there are premonitory symptoms of pain in the side of the head and twitching of the muscles of the side of the face. A patient suffering from complete facial paralysis is unable to wrinkle the brow or close the eyes, although the upper eyelid often descends somewhat during the effort. On account of the paralysis of the orbicularis the punctum lacri- malia drop away from the globe and the eye is constantly suffused with tears, and, being no longer protected from dust and cold by the motionless lips, soon becomes inflamed. 512 DISEASES OF THE NOSE, THROAT, AND EAR The ala nasi on the affected side cannot be distended during inspiration, and hence nasal respiration and the sense of smell are impaired on the affected side. The angle of the mouth drops a little and is drawn somewhat toward the unaffected side. While drinking, some of the fluid dribbles from the cor- ner of the mouth, and the food collects between the cheek and the teeth, so that it is necessary while eating to remove it from time to time with the finger. If the cheeks are distended air escapes at the corner of the mouth, and because of the paralysis of the palate-muscles it is usually necessary to employ the Eustachian catheter if the ears require inflation. The hearing is usually somewhat impaired as the result of paralysis of the stapedius muscle, but sometimes becomes still worse, if care is not exercised, from Eustachian salpingitis resulting from the paralysis of the tubopalatine muscles. When an attempt is made to smile the entire lower part of the patient's face seems to move toward the unaffected side. If recovery does not occur the affected muscles sometimes undergo atrophy, so that the affected side of the face looks smaller than the other. Contractures and spasms of the affected muscles in some cases finally occur, the spasms being clonic in character and not painful. As the result of contracture the angle of the mouth is sometimes drawn upward and the nasolabial fold deepened until at the first glance it would appear as if the unaffected side of the face were the paralyzed one. In many instances the paralysis of the facial muscles is not complete, the muscles of the lower portion of the face being the ones most affected. However, the muscles of the lower portion of the face and those of the forehead as well may be almost completely paralyzed, while the eye can still be com- pletely shut, although with considerable effort. As this form of paralysis is the most ommon after middle-ear operations, it would appear that the fibers of the nerve supplying the muscles of the lower part of the face and the forehead occupied a more superficial position within the facial canal than those supplied to the orbicularis palpebrarum. OPERATIONS UPON THE MIDDLE EAR 513 Diagnosis.-In the variety of the disease due to a central lesion the paralysis usually occurs after an apoplectic seizure, and other muscles are generally affected besides those of the face. Generally in such cases the muscles of the forehead and the orbicularis palpebrarum are affected to a considerable less degree than those of the other parts of the face, and the electric contractility of the affected muscles is not affected in the slightest degree, no matter how profound the paralysis may be. In a certain proportion of cases the unilateral paralysis of the palate, impairment of the fuction of taste at the anterior two-thirds of the tongue, and the presence of a disease of the middle ear that is capable of causing a lesion of the seventh nerve are points that will help to clear up the diagnosis. In peripheral facial paralysis it is sometimes possible to determine with a certain amount of accuracy the portion of the seventh nerve in which the lesion has occurred. If the lesion is above the geniculate ganglion there will be paralysis of all the facial muscles and those of the palate and uvula, with disturbance of hearing, but the sense of taste will be unimpaired because the chorda tympani nerve enters the facial at the geniculate ganglion. If the lesion is between the geniculate ganglion and the point at which the nerve to the stapedius muscle is given off there will be paralysis of the facial muscles, disturb- ance of hearing, and impairment of the sense of taste, but the movements of the soft palate will remain unimpaired because its motor fibers are supplied from the geniculate ganglion. If the lesion is situated between the point where the stapedius nerve is given off and the point where the chorda tympani leaves the nerve, the former symptoms will be present, with the exception that there will be no disturbance of hearing; and if the lesion is below the point where the chorda leaves the facial nerve there will simply be paralysis of the muscles of one side of the face. In order that the above should be practical for purposes of diagnosis it is necessary that the lesion should be sufficiently great to involve all the fibers of the nerve, which, of course, is not always the case. 514 DISEASES OF THE NOSE, THROAT, ANp EAR The prognosis depends upon the nature of the lesion produc- ing the facial paralysis. When a portion of the nerve has sloughed away as the result of caries of the temporal bone re- covery from facial paralysis is not to be expected, and where the nerve has been completely divided during a middle-ear operation complete recovery rarely occurs. Cases of paresis of the facial nerve and cases where only a part of the muscles of the face are involved usually result in complete recovery. The development of contractures and spasms is a most unfortunate event, as no cases where this occurs recover from the facial paralysis; and considerable deformity of the face is usually the result of the contractures and spasms. When the electric excitability of the nerve and muscles remains unchanged spontaneous recovery in from three to eight weeks may be expected, providing the middle-ear disease that pro- duced the lesion of the nerve ceases to be an active factor in the case. In many cases the excitability of the nerve and muscles to the Faradaic and galvanic currents begins to diminish within a few days of the onset of the paralysis, and is entirely lost at the end of a week or ten days; and this extinction of electric excitability continues until the patient begins to recover. Usually, in such cases, the patient is able to produce voluntary movements of the paralyzed muscles before the nerve begins to react to electric stimuli. The case should not be regarded as hopeless when electric excitability of the affected muscles is entirely lost for a short period; but such cases recover slowly, from six to nine months usually elapsing before a cure of the paralysis occurs. Treatment.-If diseased, the middle ear should, of course, receive appropriate local treatment. In rheumatic cases and those resulting from disease of the middle ear it is well to place the patient upon full doses of iodid of potassium and an ointment composed of equal parts of mercurial, iodin, and bella- donna ointments should be rubbed into the skin over the mas- toid and below the ear sufficiently often to keep the parts slightly sore to the touch. After from one to three weeks have OPERATIONS UPON THE MIDDLE EAR 515 elapsed and reaction has set in, it is well to begin the use of electricity, preferably the Faradaic current to the affected muscles, but in some cases better results are obtained from the employment of the galvanic current. A weak galvanic current may be sent along the affected nerve-trunk by placing a medium- sized electrode over each ear (the negative on the affected side), and passing a current between them. The Faradaic current may be applied to the affected muscles by placing a small electrode over them in turn; or the electrode may be passed along a line in front of the auricle in order to reach the fibers of the pes anserinus where they cross the side of the face. The current should be of sufficient strength to produce contrac- tions of the affected muscles, and the sittings should last not longer than ten minutes every day or every other day. Dur- ing an operation if the nerve is cut, the ends should be approx- imated in the hope that whey will unite. If it is impossible to suture, some fine fibers of catgut should be passed along side the nerve and the part protected from the dressing by a strip of rubber tissue. In cases where a considerable section of the facial nerve has been removed during a mastoid operation and in some other cases successful neuroplastic operations have been reported. The facial nerve is located at the posterior border of the parotid gland and dissected back to the stylomastoid foramen, where it is cut off as high up as possible. The cut end of the nerve is then implanted into the trunk of the spinal accessory, glossopharyngeal, or, preferably, the hypoglossal. DISEASES OF THE PERCEPTIVE APPARATUS Diagnosis Between Middle-ear Deafness and that Result- ing from Disease of the Internal Ear.-The diagnosis is made from the history of the case and by means of tuning-forks. It must not be supposed that tests with the tuning-fork are infallible, for example, in cases in which the capsular ligament around the stapediovestibular joint has become stiff as the result of disease, it is easy to understand how the stapes can 516 DISEASES OF THE NOSE, THROAT, AND EAR become fixed in the oval window as the result of a blow on the side of the head or the concussion produced by the unex- pected discharge of firearms. Under such circumstances suspension of the function of hearing will result from increased intralabyrinthine pressure. The symptoms under such cir- cumstances would all point toward disease of the labyrinth, and yet the hearing may become nearly normal as the result of vigorous inflation of the middle ear by Politzer's method. It is evident that in a case of this kind there was no actual disease of the labyrinth. Anemia of the labyrinth may be part of a general anemia or due to some local cause affecting the blood-supply, such as tumors of the brain, endocarditis, osteosclerosis, or embolism of the auditory artery. Symptoms.-After profuse hemorrhage from any cause there is tinnitus, vertigo, and nausea as the result of anemia of the labyrinth. These symptoms are made worse by sitting or standing and are ameliorated by lying down. The same is true of anemia of the labyrinth from other causes than hemor- rhage. In anemia of the labyrinth the acuteness of hearing is impaired, both for aerial and bone-conduction. Hyperemia of the labyrinth may result from most of the acute infectious diseases, middle-ear inflammation, some intra- cranial diseases, valvular disease of the heart, the menopause, plethora, gout, alcoholism, quinin, amyl nitrite, salicylic acid compounds, calcium chlorid, the irritation resulting from long use of the telephone receiver, loud noises, vasomotor disturb- ances, etc. The symptoms are similar to those of anemia, except that they are intensified by the horizontal position. The auricle, auditory canal, and drum-head may visibly participate in the hyperemia. Occasionally individuals are encountered in whom a few grains of quinin or salicylate of sodium will produce visible hyperemia of the auricle, canal, and drum-head; also tinnitus, presumably from hyperemia of the labyrinth. The treatment is systemic. The symptoms are made worse OPERATIONS UPON THE MIDDLE EAR 517 by inflation and massage. Relief of tinnitus may be obtained from hydrobromic acid or the bromids, but comparatively large doses (20 to 30 gr. three times a day) are required. Significance of a Discharge of Blood from the Internal Ear.-Occurring after traumatism a discharge of blood from the internal ear through the tympanum and external auditory canal may indicate fracture of the base of the skull. Cerebro- spinal fluid may escape from the ear either as the result of frac- ture of the base of the skull or injury of the structures of the oval or round windows or the aquaeductus Fallopii. Concussion of the Labyrinth.-The symptoms are sudden deafness following concussion or a blow, without visible local injury. Tinnitus is usually present. The prognosis is unfavorable, but to | gr. of pilocarpin should be injected subcutaneously each day until symptoms of weakness of the patient occur or it is manifest that the treatment is unavailing. Hysteric deafness is a somewhat rare symptom occurring in hysteric women. The deafness may be complete, lasting for several hours or days. Treatment is the same as for other hysteric conditions. Syphilis of the Internal Ear.-Plastic exudations may occur within the labyrinth similar to those occurring in plastic iritis. The disease is ushered in by loud subjective noises, deafness soon following. There is usually a noticeable disturbance of the patient's gait and he complains of constant dizziness. The prognosis is not altogether unfavorable if vigorous antisyphilitic treatment is begun early. In congenital cases, ear symptoms usually occur between the ages of ten and fourteen years; in many instances following interstitial keratitis. A course of pilocarpin sometimes quickly, but often only transiently, benefits such cases and should not be allowed to interfere with antisyphilitic treatment. However, salvarsan should be used with caution as it is sometimes followed by Meniereform polyneuritis appearing some weeks after an injection at a time when the Wassermann reaction has become negative and there is every reason to attribute the disaster to the remedy. 518 DISEASES OF THE NOSE, THROAT, AND EAR Metastasis may occur in parotitis or mumps to the laby- rinth, with an exudation of a plastic material, the symptoms being deafness, tinnitus, and vertigo. If the affection is treated early, before the organization of the plastic material, with hypodermic injections of pilocarpin, the prognosis is not altogether unfavorable. "Meniere's disease" is a name given to a group of symp- toms which may be caused by various affections of the laby- rinth, the acoustic nerve, or the central nervous system, usually apoplectiform in character. There are sudden loss of hearing, tinnitus, and vertigo often to such a degree that the patient is unable to maintain his balance and falls to the ground (see p. 408). Hemorrhage into the labyrinth may occur as the result of degeneration of the blood-vessels, traumatism, hyperemia, con- cussion from explosions, etc. The symptoms are sudden deafness, nausea, syncope, vertigo, with a tendency to fall toward the affected side and patho- logical nystagmus spontaneous or induced by the turning, caloric or galvanic tests, by which it is possible often to differentiate at least approximately the portion of labyrinth in solved. Prognosis.-If the hemorrhage is small it may be completely absorbed, with a restoration of the normal functions of the ear, but should the extravasation undergo fibrous degeneration the partial deafness will be permanent. Tinnitus, vertigo, and nausea, however, will disappear. Treatment consists in free catharsis and abolute rest in bed. Pilocarpin hydrochlorate may be given in ro-gr. doses once or even twice a day with the usual precautions for five or six days or longer if it produces a decided improvement in the aural symptoms. lodid of potassium should be given in conjunction with or after the use of pilocarpin, in 10- or 15-gr. doses three times a day, or, if there is a history of syphilis, the dose should be further increased. After the lapse of some months quinin may be given slightly above the tonic dose to increase the OPERATIONS UPON THE MIDDLE EAR 519 supply of blood to the labyrinth and promote absorption if deafness and tinnitus still persist. Diseases of the Static Labyrinth or Vestibular Appara- tus.-The faculty of equilibrium depends upon three sets of sensations, derived respectively from the eyes, labyrinths, and muscles. If one set of functions is completely destroyed, vertigo does not result because the remaining two are sufficient to maintain equilibrium. Hence the destruction of both vestibules with their semicircular canals does not cause dizzi- ness because sight and muscular sense are still sufficient to maintain equilibrium; but if, in addition to paralysis of the labyrinths, either sight or muscular sensations are destroyed, vertigo results. Infants gradually learn to maintain equilibrium by the correlation of these three sets of sensations; but if a child is born with a labyrinthine lesion, he becomes accustomed to the false impressions derived through it and has no vertigo. If an adult, accustomed all his life to normal sensations from his organs of equilibrium, acquires a labyrinthine disease, he will be subjected to conflicting sensations with resulting vertigo, which persists until he becomes accustomed to these conflict- ing sensations. If the labyrinthine disease is progressive, he may never become accustomed to the resulting conflicting sensations, and hence never entirely recover from his vertigo. For example, in Meniere's disease, when the entire vestibular apparatus of one ear is paralyzed or destroyed as the result of hemorrhage, the consequent vertigo remains until the patient becomes accustomed to the loss of sensations from the de- stroyed vestibule. In cases where there is a succession of small hemorrhages, the patient must become accustomed to sensations varying with each new lesion, and consequently has recurrent vertigo. Even when free from vertigo, such patients should be cautioned about ascending ladders or going on scaf- folding, etc.; but when there is complete destruction of the semicircular canals after recovery from the transient vertigo it has caused, this precaution is not necessary. 520 DISEASES OF THE NOSE, THROAT, AND EAR Hbgge's Law.-•Cortical nuclei of each side enervate the adductor muscles of the corresponding eye and the abductors of the other eye. When such a center is stimulated, there is a slow movement of the eyes away from the nucleus fol- lowed by a quick toward it (Fig. 221). Ewald's Law.-Ewald, as the result of experiments upon the semicircular canals of pigeons, demonstrated that nystag- Fig. 221.-Diagram illustrating the action of Hogge's law. Stimulation of the lelt nuclues produces contraction of the adductor muscles of the left eye and abductor muscles of the right eye, and hence a slow movement to the right followed by a quick movement to the left. mus resulting from endolymph currents in a semicircular canal is in a direction parallel with the plane of that canal and opposite to the current. Vestibular nystagmus may be horizontal, vertical, oblique, or rotary. It results from stimulation of the vestibular apparatus and cortical nuclei. The former produces a slow movement and the latter a quick movement. Because the quick movement is more readily observed it is the one generally referred to as "nystagmus." Hence, "horizontal nystagmus to the right " means the quick movement of the eyes to the right. However, this quick movement ordinarily disappears under general anesthesia, while the slow movement does not. Nystagmus of vestibular origin consists of (i) a quick move- ment of the eyes (cortex) and a slow return movement in the OPERATIONS UPON THE MIDDLE EAR 521 opposite direction (vestibule). (2) It increases in length of excursions and rapidity when the eyes are turned voluntarily towardt he direction of the quick movement, and (3) it weakens or disappears when the eyes are turned in the direction of the slow movement. Neither nystagmus resulting from ocular lesions nor nystag- mus of cerebellar origin has these characteristics. Cerebellar nystagmus gets worse as the disease progresses; vestibular nystagmus decreases with time, whether the vestibular disease gets well or progresses to complete destruction of the labyrinth. Fig. 222.-Semcircle resulting from joining the indifferent ends of (a) horizontal and (&) vertical semicircular canals, brought into the horizontal plane by bending the head forward at a right angle. The arrows represent the endolymph current at the end of the turning to the right; the + and - signs, the direction of the consequent motor impulses._ In the horizontal canals the motor impulse derived from the am- pulla whose hair cells are bent towai d the utricle is about twice as strong as that derived from the other ampulla. In the vertical canals the motor impulse is twice as great from the ampulla whose hair cells are bent away from the utricle. Spontaneous vestibular nystagmus may be apparent even when the eyes are directed forward, or only seen when the eyes are turned in the direction of the nystagmus. In some cases of vestibular disease, nystagmus only occurs as the result of the application of turning, caloric, or galvanic tests, which also develop nystagmus in normal individuals. For purposes of study the semicircular canals can be divided into an ampulla end, containing the sensitive hair-cells, and an indifferent end. If, for example, the indifferent ends of the horizontal semicircular canals could be joined together, a 522 DISEASES OF THE NOSE, THROAT, AND EAR semicircle would result with an ampulla at each end, and these ampullae according to Ewald's law, work together, increasing nystagmus. If the arrows (Fig. 222 a, lower figure) repre- sent the direction of the endolymph current, the resulting nystagmus (quick movement, upper figure) is in the opposite direction as the result of impulses derived from each am- pulla. However, in the horizontal canals the stimulation derived from the ampulla whose hair cells are bent toward the utricle is twice that of the other ampulla. Hence the con- venient but not strictly correct formula "Turning to the right determines the condition of the left vestibular apparatus; turning to the left that of the right vestibular apparatus." Functional Tests.-Turning. To produce nystagmus by turning, the semicircular canal to be tested must be in the same plane as the turning. To ex- amine the condition of the horizontal semicircular canals the patient is seated in a chair that is revolved somewhat rapidly ten times. Because of the inertia of the endolymph, at the beginning of the turning, if it be to the right, the cilia in the right ampulla are bent toward the utricle and away in the left ampulla; but at the end of the turning, because of this same inertia, the current of endolymph continues to flow in the direction of the turning, and, according to Ewald's law, there will be horizontal nystagmus toward the left (Fig. 222). In normal individuals after-turning nystagmus lasts about 24 seconds if the eyes look straight ahead. The length of time after-turning nystagmus lasts is increased if one or both laby- rinths are inflamed. If one labyrinth is destroyed, the after- turning nystagmus will result only from impulses from the remaining normal labyrinth. Its duration will be diminished to a different extent according as the turning is to the right or left. For example if the right labyrinth is destroyed, after- turning nystagmus to the right is reduced to 24" -16 " - 8"-this 8 seconds of nystagmus representing the reaction from the left or well ear. After-turning nystagmus to the left on the other hand is 24" - 8" = 16". This 16 seconds of nys- OPERATIONS UPON THE MIDDLE EAR 523 tagmus also representing the reaction from the left or well ear; because as already stated, the stimulation from an ampulla whose hair cells are bent toward the utricle is twice as great as when the cells are bent in the opposite direction. Caloric tests, the significance and technic of which were established by Barany of Vienna, depend upon the fact that if a normal ear is irrigated with water io° below the body tem- perature there will be produced rotary nystagmus toward the other ear. There is also produced vertigo and marked ataxia. If hot water is used, there is nystagmus toward the irrigated ear. In either instance the nystagmus is increased by the patients looking in the direction of the nystagmus. If the vestibular nerves are irritated, for example by a small circum- scribed abscess, there will be spontaneous nystagmus toward the affected side and syringing will produce a positive reaction. If the nerve endings are rapidly destroyed as for example by diffuse suppuration, there will be spontaneous nystagmus for a few days or weeks toward the sound side; its origin being the sound ear and syringing the diseased ear will yield no response. When such a case is of sufficiently long standing for the nystagmus to have disappeared, there will be neither spontaneous nystagmus nor response to functional tests. Finger test is made after syringing. After cold syringing, the patient falls toward the syringed ear, if standing with his eyes closed and misses the finger held a short distance from his face when asked to touch it. The examiner and patient stand facing each other. The patient then closes his eyes or is blindfolded. He extends the arm to be tested straight in front of him with his index-finger, palmar surface up, pointed toward the examiner who places his own forefinger firmly on it. The patient is then instructed to drop his arm into a hanging or vertical position and then slowly raise it so that his forefinger will again touch that of the examiner. The normal individual does this without difficulty. Cere- bellar abscess on the same side as the arm examined will cause a deviation of the arm away from the body when the arm is 524 DISEASES OF THE NOSE, THROAT, AND EAR lowered and again when it is raised so that the patient misses the examiner's finger by a considerable distance. In other words, the finger when lowered and elevated describes a V away from the body. When the cerebellar disease is unilateral the pointing or finger test is normal on the unaffected side. If as the result of the pointing test a cerebellar abscess, for example, is suspected on the right side, the suspicion is corroborated by syringing the left ear with cold water. This produces a transient rotary nystagmus to the right and a tendency to fall toward the left. If during this period the Fig. 223.-Semi-schematic representation of two labyrinths showing relative positions of semicircular canals to each other (modified after Mackenzie). pointing test is applied, in normal individuals both hands will deviate toward the left, but when a right cerebellar abscess is present the right forefinger will still deviate toward the right when the pointing test is applied. Electric tests apply only to the auditory nerves and have no bearing on the labyrinth. If a patient shows no reaction to either the turning or caloric tests, but a normal reaction to electric tests, a normal vestibular nerve and a destroyed laby- rinth is probable. If there is no reaction to the three tests, OPERATIONS UPON THE MIDDLE EAR 525 disease of the nerve trunk or even the vestibular nucleus is present. The galvanic test is usually made by the patient holding one sponge in his hand while the other is applied to the ear to be tested. In a normal ear, nystagmus and ver- tigo result from the passage of 4 or 5 Kathode or anodal milliamperes. Fistula Test.-When a fistula leads into the external semi- circular canals if the labyrinthine contents are compressed by quickly squeezing a politzer bag whose nozzle is fitted tightly into the meatus, vertigo and rotory nystagmus toward the diseased ear is produced. Suction by'means of the bag causes vertigo and rotary nystagmus toward the sound ear. The nystagmus is in the opposite direction when the fistula is at the oval window. Labyrinthitis may be circumscribed or diffuse. The cir- cumscribed is either paralabyrinthitis, inflammation of the bony capsules; or perilabyrinthitis, inflammation of the peri- lymph; or a combination of the two. Endolabyrinthitis, or inflammation of the endolymph spaces never occurs independ- ently. Therefore the diffuse form is either a combined peri- and endolabyrinthitis, that is empyema; or panlabyrinthitis which is a combination of para-, peri- and endolabyrinthitis. Both the circumscribed and the diffuse forms may be either acute or chronic, exudative, plastic or necrotic, and the exuda- tion, serous or purulent. Pathology.-No undoubted case of primary labyrinthitis has been reported. The disease is either meningeal, tympanic or metastatic in origin. The tympanic form is by far the most common and may result for scarlatina, cholesleatoma, tuber- culosis, trauma, etc. The most common location of circum- scribed labyrinthitis is a semicircular canal, usually the hori- zontal. Circumscribed inflammation of the cochlear usually involves the first half of the basal whorl. Infection through the oval window may result in a localized inflammation of the cisterna perilymphatica; which may spread to other peri- lymphatic spaces without involving those of the endolymph. 526 DISEASES OF THE NOSE, THROAT, AND EAR Diffuse labyrinthitis may be such from the beginning or a circumscribed inflammation may break down its barriers and become diffuse. In some cases a circumscribed abscess at the fundus of the internal auditory canal in the subarachnoid space is walled off by the attachment of the arachnoid sheath of the nerve to the dural lining of the canal which is an anatomical peculiarity of this region. Purulent inflammation in the middle ear may induce serous inflammation in the labyrinth or purulent inflammation in part of the labyrinth, may induce serous inflammation of another portion. Laby- rinthitis ends either in recovery with restoration of function; healing with permanent changes or extension to the intra- cranial cavity; the route of infection being the internal auditory canal, the aqueductus cochlea, theaqueductus vestbuli or along vessels of the fossa subarcuata. Symptoms.-Stimulation of the cochlea nerve causes tinnitus; destruction, deafness. Stimulation of the static labyrinth causes vertigo, disturbances of equilibrium, nausea, vomiting and a nystagmus toward the stimulated labyrinth (stimulated disharmony). Similar symptoms follow destruc- tion of the labyrinth but the nystagmus is directed to the sound side. (Destruction disharmony.) The vomiting differs from that caused by intracranial lesions; because it is never of the projectile type and is always accompanied by nausea. Even in diffuse suppuration the temperature is usually normal; therefor fever is usually indicative of commencing meningitis. At least 80 per cent, of necrotic cases are com- plicated by facial paralysis. The tendency to fall is in the direction of the slow component of the nystagmus. If a nystagmus to the right exists, the body will tend to fall to the left. If the face is turned to the right shoulder the body will tend to fall forward; toward the left shoulder, backward. This is not the case when the disturbances of equilibrium are not of vestibular origin. Circumscribed Labyrinthitis causes symptoms of stimulated disharmony of sudden onset and often transient duration, OPERATIONS UPON THE MIDDLE EAR 527 brought on by stooping, straining or moving the head rapidly. There may be spontaneous nystagmus. Rotation shows both labyrinths functionating normal and the caloric and fistula tests are positive. Diffuse Serous Labyrinthitis may occur after a radical mastoid operation, removal of polypi or even spontaneously as the result of circumscribed disease. After operation it occurs in from one to three days. Destructive disharmony resulting from mechanical injury of the labyrinth occurs at once. There is great diminution in hearing and a disposition to lie on the sound side so that the eyes may be directed toward the slow component of the nystagmus when these Symptoms last for one or two weeks as they sometimes do; there usually results some permanent loss of function. However even at the height of the attack there is usually reaction to either the turning, caloric or fistula test or perhaps to all of these tests, and so long as some function remains, infection of the intra- cranial contents rarely or never occurs. Moreover in cases that go on to suppuration; when all function has been destroyed there is an interval of some hours or days before the infection extends to the meninges as it usually does. Diffuse Suppurative Labyrinthitis is either manifest or latent. In contradistinction to diffuse serous labyrinthitis the symptoms are most violent. There is sudden complete deafness; per- sistent nausea and vomiting; rotatory nystagmus to the sound side and disturbances of equilibrium to the extent that the patient is unable to walk without assistance and lies in bed upon the side of his sound ear. The difuse latent form is as dangerous as it is insidious. There is frequently neither his- tory or symptoms except there is complete deafness and the caloric and fistula tests are negative. If the disease has lasted so long that the intralabyrinthine spaces are filled with a new bone formation, the after-turning nystagmus of the sound side equals that of the diseased side but both are shorter than normal. The same anomalous reaction occurs after sequestration in necrosis. Except in these cases, when latent 528 DISEASES OF THE NOSE, THROAT, AND EAR suppurative labyrinthitis exists, polyp extraction or even a radical mastoid must be looked upon as an incomplete operation and exceedingly dangerous; because of the frequency of intra- cranial extension of the labyrinthine infection. Differential Diagnosis.-Labyrinthine inflammation must be differentiated from hysteria, affections of the auditory nerve, meningitis and abscess or tumor of the cerebellum. In hysteria the middle ear may show no pathological changes. If nystagmus is present it is not of the vestibular type; nor are the disturbances of equilibrium of that type, that is the body will have a tendency to fall backward or forward or to the side according to no definite rule and not always toward the direction of the slow component of the nystagmus. Deafness may be simulated but the static labyrinth will react to the functional tests. The diagnosis between affections of the auditory nerve and labyrinth are made by the caloric and galvanic tests. The caloric test determines the comparative susceptibility of the two labyrinths; the galvanic of the two auditory nerves. If nystagmus toward the side of the de- stroyed labyrinth develops after a labyrinthine operation, it indicates either disease of the other labyrinth, meningitis or cerebellar abscess. If functional tests exclude disease of the unoperated labyrinth, in the presence of intracranial symp- toms, exploration of the posterior fossa and perhaps cerebellum is justifiable. When a labyrinth has been destroyed by disease and not operated on, the diagnosis from meningitis or cere- bellar abscess is never easy. However there is temperature, and pressure symptoms and turbid cerebrospinal fluid obtained by lumbar puncture. In cerebellar abscess, tumor or localized meningitis there is spontaneous nystagmus toward the diseased side. Therefore if there be spontaneous nystag- mus for a time toward the well side succeeded by nystagmus toward the diseased side, cerebellar abscess is probable. Nystagmus in a normal ear suggests cerebellar tumor; with suppuration of the middle ear, deafness and no response to the caloric test, cerebellar abscess is probable. The disturb- OPERATIONS UPON THE MIDDLE EAR 529 ance of balance do not diminish in cerebellar abscess as in labyrinthitis. Treatment.-Most cases of labyrinthitis recover without operative treatment; some with complete or partial restorative of function. The fatal cases are usually of the diffuse purulent type; but even such cases heal spontaneously. This is especially true of cases complicating scarlet fever. More frequent than spontaneous healing is a subsidence into a latent chronic stage which may last for years and finally produce serious intracranial complications, especially if a middle- ear operation be done. No case of circumscribed labyrinthitis should be operated on unless a complete operation be done because the breaking down of the barriers that nature has erected to the spread of the disease is extremely dangerous without the adequate drainage of a complete operation. A radical mastoid should not be done where diffuse, purulent labyrinthitis is present, but many chronic and subacute cases admit of an interval of some days between the radical mastoid operation and exenteration of the labyrinth. Alexander believes that no extensive operation should be done on the labyrinth without exposing the dura and exploring the region of the sacculus endolymphaticus as extradural abscess is common in this locality, when circumscribed labyrinthitis occurs in chronic suppuration, cholesteatoma is usually present and a radical mastoid is therefore necessary. If during the operation the fistula, usually at the eminence of the external semicircular canal is discovered, it should neither be probed nor curetted, but the patient should be carefully watched for the occurrence of either diffuse serous or purulent labyrinthitis which usually occurs if at all, on the second or third day after the operation. If there is complete loss of hearing and negative functional tests with some elevation of of temperature, the labyrinth should be exenterated in the hope of preventing the spread of the infection to the cranial cavity. On the other hand cases of diffuse serous labyrinthitis usually subsides in a week or two and it is not necessary to operate. 530 DISEASES OF THE NOSE, THROAT, AND EAR The occurrence of facial paralysis in chronic suppuration when the functional tests are negative is positive proof of a latent labyrinthitis. Non-operative treatment of labyrinthitis consists simply of rest in bed, the patient determining for himself the position best suited for diminishing vertigo and nystagmus. He should remain in bed as long as vertigo exists; from a few days to several weeks. Bromides, io grains three or four times a day, lessen the nervous irritation and galvanism sometimes relieves the vertigo. An electrode is placed in front of each ear, the anode on the side toward which the nystagmus is directed. Labyrinthine operations consist of labyrinthotomy or open- ing the labyrinthine spaces, and labyrinthectomy or removal of the labyrinth as far as practical. In the first group belong the operations of Hinsberg, Richards and Bouquets; to the second those of Jansen and Neumann. The simple enlarge- ment of a fistula is of no value for draining an infected laby- rinth and a wide opening of the vestibule and basal whorl of the cochlea is necessary. When there is involvement of the bony capsule a labyrinthectomy should be done. In sequestration of a portion of the labyrinth, the sequestrium is removed and the rest of the labyrinth left intact in order not to destroy protective granulations. Hinsberg's Operations.-The oval window is enlarged at the expense of its lower margin after removal of the stapes if present; the chisel being directed toward the round window so that the bridge of bone between the oval and round windows is removed. He sometimes also removes the promontory exposing the basal whorl of the cochlea. Neumann's operation is done after a complete radical mas- toid. The inner table over the lateral sinus is removed with a large gouge and also the intervening bone over the dura forward to the labyrinthine capsule either with chisel or ron- geur. The dura is now carefully separated from the posterior surface of the pyramid which is somewhat difficult because of OPERATIONS UPON THE MIDDLE EAR 531 the depressions into which processes of dura extend. The posterior surface of the pyramid is removed layer by layer with a gouge. A derivation of the chiseling upward endangers the superior petrosal sinus; downward, the jugular bulb and outward the facial nerve. The chiseling is continued forward until the pyramid of bone containing the semicircular canals is removed and the 7th and 8th nerves are exposed in the internal auditory canal. As the chiseling proceeds there appears at the level of the round window the convexity of the posterior semicircular canal. There next appears the lower limb of the posterior semicircular canal on a level with the round window and the common limb of the posterior and superior canals on a level' with the lower margin of the oval window. A third opening soon appears between the other two, the posterior limb of the external canal. A probe passed either through the common limb or the external canal enters the vestibule readily. The external canal is uncapped by the chisel until the vestibule is opened. Jansen advises that the operation cease at this stage but Newmann continues the chiseling of the posterior surface of the petrous pyramid until the posterior wall of the internal meatus is removed. If the dura is acci- dentally torn the opening is enlarged to | inch as only small tears are dangerous. Starting at the oval window and directing the stroke of the chisel downward and forward, the lower half of the basal whirl of the cochlea is opened and when the cochlea is a mass of sequestra pus and granulations, it is scraped out with a curette. After-treatment is the same as after a radical mastoid opera- tion. The bone cavity fills with granulations and becomes covered by epidermis. FORMULAS AQUEOUS DETERGENTS, SPRAYS, AND WASHES USED TO CLEANSE MUCOUS MEMBRANES Dobell's Solution i. 1$. Sodii bicarbonatis, Sodii biboratis, aa 3 j; Acidi carbolici, gr. xlviij; Glycerini, 3iii|; Aquas, Oij.-M. The above is stated to be Dr. Horace Dobell's original formula. Diluted with an equal amount of water. It may be used either as a spray to cleanse the mucous membrane of the nose, throat, and larynx, or may be pre- scribed as a wash for the patient's use at home. The temperature of a spray is not materially altered by that of the fluid in the atomizer-bottle, but when used as a nose-wash with a syringe or douche or by "sniffing up the nose," the solution should be warmed to about no° to 1300 F. Higher temperatures are sometimes of advantage in acute inflammation. 2. I|. Sodii bicarbonatis, Sodii biboratis, aa 3j; Sodii salicylatis, gr. iij; Menthol, Thymol, aa gr. j; Glycerini, f§j; Aquae torridi, . f§iv.-M. Sig.-Add enough water to make 1 quart and use with an atomizer or as a nose-wash. This formula yields a wash nearly as unirritating as Dobell's solution, and it has not the objectionable odor of carbolic acid. The concentrated wash is sufficiently antiseptic to preserve small anatomic specimens indefinitely, and the diluted wash will preserve them for a considerable time. The solid ingredients of the wash may be compressed into a tablet of such size that one added to 4 tablespoonfuls of water will make a wash of the requisite concentration. Under such circumstances borax should be substituted for the glycerin of the formula in sufficient quantity to yield a wash of a specific gravity of 1020, because a wash of greater or less specific gravity than 1020 is irritating to the nasal mucous membrane. Both Dobell's solution and the formula above, should be compounded at least three or four days before being used. During this time carbonic acid gas escapes, and glyceroles and other compounds are formed that render the solutions much more bland and unirritating to the nasal mucous mem- brane. Of the two, Dobell's solution, probably because of the sedative 533 534 DISEASES OF THE NOSE, THROAT, AND EAR qualities of dilute solutions of carbolic acid, is less irritating, but has the disadvantage of the smell and taste of carbolic acid, which is very objec- tionable to some patients, especially ladies. The following is a good deter- gent wash: 3. I). Liquor antiseptici alkalinis (N. F.), f§iv. Sig.-Dilute with 7 parts of water and use as a spray for cleansing the nose. 4. 1$. Liquor antiseptici, fgiv. Sig.-Dilute with 7 parts of water and use with an atomizer or nasal syringe. This preparation has an acid reaction and is somewhat irritating to nasal mucous membranes, but for this very reason is sometimes prescribed in atrophic rhinitis. 5. I). Potassii chloridi, 0.2 gm. or gr. iij; Sidii bicarbonatis, 0.2 gm. or gr. iij; Sodii chloridi, 9 gm. or gr. cxl; Aquae, q. s. ad. liter j or f§xxxiii|.-M. (Ringer.) Sig.-Normal salt solution for intravenous injection, hypodermoclysis, etc. Normal salt solution is used as a detergent wash. For this purpose it is probably less effectual than Dobell's solution and other bland alkaline washes. In surgery it is sometimes used for irrigation, instead of sterile water. In threatened collapse from hemorrhage or other causes 1 or 2 pints may be injected into the median cephalic vein, or fluid may be added to the general circulation by rectal injection (enteroclysis), or by subcu- taneous injection into the cellular tissue of the thigh, abdomen, or buttocks (hypodermoclysis). 6. I). Sodii bicarbonatis, § ss; Aquae destillatae, f Biij.-M. Sig.-Saturated solution of sodium bicarbonate. Use clear fluid above the undissolved bicarbonate as a detergent. 7. 1$. Acidi borici (crystals), gij-iv; Aquae fervidi, fgiv.-M. Sig.-Place the boric acid in a wide-mouthed bottle and add the warm water. Syringe the ear with this saturated solution and add hot water as required from time to time to secure a saturated solution of suitable tem- perature for syringing the ear. As the boric acid crystals dissolve, add more, so that a portion always remains undissolved. Useful in the "cleansing treatment" of chronic otorrhea. However, in most cases with extensive destruction of the drum-head, better results are secured by home syringing with corrosive sublimate (1:5000 to 1:10,000). 8. I|. Hydrargyri bichloridi, gr. viiss; Aquae destillatae, Oj.-M. Sig.-Bichlorid of mercury solution (1:1000). FORMULAS 535 Bichlorid of mercury solutions should rarely, if ever, be used in the nose, or accessory cavities as they are extremely irritating even when very dilute. Because under ether an unknown quantity may pass through the Eus- tachian tube and be swallowed, it is better to irrigate mastoid wounds with sterile water or normal salt solution. When the operation is completed, only enough bichlorid solution to blanch the tissues and prevent capillary oozing may be used with safety. Periostitis and inflammation of the cel- lular tissue, after mastoid and other operations, is probably best treated by saturating the dressings with bichlorid solution. For this purpose i: 3000 or 1: 5000 solutions are strong enough, as some skins are so sensitive as to blister if a more concentrated solution is used. If deemed necessary the attic may be syringed with an intratympanic syringe with 1:1000 bichlorid without any decided reaction occurring, but for the patient's home syringing, in the so-called " cleansing treatment" of chronic otorrhea, stronger solutions than 1:5000 or 1:10,000 should not be. employed. According to McClintock mercuric iodid and bicarbonate of sodium yield a solution of greater germicidal power, and at the same time less irritating to the tissues than bichlorid of mercury. The author has used the following 1:5000 solution for syringing the attic: 9. I}. Hydrargyri biniodidi, gr. viiss; Sodii bicarbonatis, 5 vss; Aquas, q. s. ad. Oj.-M. Sig.-Diluted with 5 to 10 parts of water for syringing the attic. 10. Hydrogen dioxidi. Commercial hydrogen peroxid is sold usually as a 3 per cent., equal to a 15 volume, solution of the gas. Its strength can readily be increased by evaporating the solution in a shallow vessel at a temperature considerably below the boiling-point, as under such circumstances the evaporation is much more rapid than the decomposition of the solution, and a strength of 100 volumes or even more is readily obtained. The stronger solutions are caustics, quickly destroying living tissue. The ordinary 15-volume solu- tion is very irritating to the mucous membrane of the nose and pharynx and, therefore, it should not be prescribed indiscriminately in catarrhal affections. Its chief use in rhinology and otology is for the removal of pseudomem- branes, the cleansing of pus-cavities, and as a hemostatic, but when used for any of these purposes its irritating qualities should be borne in mind. When brought into contact with organic substances hydrogen peroxid is decomposed with the liberation of nascent oxygen, which unites with the organic substance, often greatly increasing its bulk. When applied to a pseudomembrane in the pharynx the membrane is not only softened and decomposed, but its increase in bulk greatly facilitates its removal. For the removal of pseudomembranes the peroxid is best applied by means of a swab, made by wrapping cotton about the end of an applicator. In this manner the peroxid may be not only rubbed into the pseudomembrane, but the rubbing assists in detaching it from the mucous membrane. Of course the "rubbing" should be done with judgment and gentleness, and it is rarely necessary to use a solution stronger than 3 per cent. The action of the swab may be assisted, if necessary, by spraying the membrane, if desirable, by means of an atomizer. For cleansing the middle ear, the antra of Highmore, or other cavities of pus, 3 per cent, peroxid, diluted with 1 or 2 parts of water, is generally 536 DISEASES OF THE NOSE, THROAT, AND EAR sufficiently strong. Care should be used in injecting peroxid into a cavity that there is an opening sufficiently large to permit the easy escape of the gases generated by the decomposition of the peroxid. Should this not be the case, the pressure generated may be sufficient to cause great pain and, in the case of the middle ear, syncope and vertigo. In fact, it is injudicious to inject peroxid through a small opening in the drum-head or a narrow sinus leading upward into the attic and mastoid antrum. It is stated that in the attic peroxid is capable of doing more harm than good by carrying pus into localities previously unaffected during its ebullition and thus spreading the infection. In the antra of Highmore peroxid is valuable for loosening and disintegrating masses of adherent mucopus, and it is judicious to use at least one syringeful of diluted peroxid when cleansing that cavity. As a hemostatic peroxid acts by causing an immediate clotting of the blood with which it is brought into contact, and the clot formed under such circumstances.is very bulky and firm. When pledgets of cotton soaked in peroxid are inserted into a bleeding nostril the blood coming into contact with the peroxid is immediately clotted, and until the peroxid is exhausted the more bleeding the more clotting, and consequently the more pressure upon the bleeding vessel. Remedies like adrenalin, that cause contraction of the blood-vessels, are generally of little use for controlling nasal hemor- rhage, because the flow of blood prevents them from coming into contact with the nasal mucous membrane and producing any effects. LOCAL ANESTHETICS ii. Cocain. When it is desired to produce local anesthesia of any portion of the inte- rior of the nose for the purpose of operation, a cotton pledget saturated with a i: 2000 adrenalin solution should be applied to the parts for ten minutes, and then, by means of a cotton-tipped applicator, a saturated solution of cocain should be well rubbed into the mucous membrane with especial reference to the line of incision. Anesthesia of the larynx is produced by covering with a fine spray of a 10 per cent, cocain solution the laryngeal mucous membrane, and repeating the procedure after an interval of two or three minutes. The sensibility of the larynx should then be tested with a cotton-tipped appli- cator dipped in a 10 per cent, solution of cocain from time to time, until the applicator can be moved about freely in the larynx without producing a reflex spasm, as there is little use in beginning an operation on the larynx when every touch of an instrument is followed by spasm or retching and gagging. Anesthesia of the larynx, produced by the application of a solution of cocain, appears quickly after the application and lasts only a short time. Apparently cocain can be used more freely in the larynx than in either the nose or ear without danger of poisonous effects. Watery solutions are not absorbed with sufficient facility by the skin to render their use inside the auditory canal at all satisfactory for producing local anesthesia. Diminished sensibility of the drum-head and of the wall of the canal may, however, be secured by a 10 per cent, ointment of cocain in lanolin, and this ointment is probably better than preparations of mor- phin, atropin, etc., for the relief of the pain of otalgia. When prescribed for this purpose it is simply inserted within the meatus, due care being FORMULAS 537 exercised when the drum-head is absent not to use a sufficient quantity to produce a poisonous effect. When the drum-head is present the ointment will remain for days in contact with it and be slowly absorbed. Its seda- tive effects are, under such circumstances, followed by no reaction. For the production of local anesthesia for the removal of aural polypi a pledget of cotton saturated with a 4 per cent, solution may be allowed to remain for five minutes in contact with the parts. This method, however, is not adequate for the production of local anesthesia in removal of the ossicles or, in fact, any of the more painful and tedious intratympanic op- erations, which ordinarily necessitate the almost complete local anesthesia resulting from the subcutaneous injection of equal amounts of a 1 per cent, solution of cocain and a 1:1000 solution of adrenalin in several places be- neath the skin of the canal at the junction of the bony and cartilaginous portions. An ordinary hypodermic syringe with a small needle connected by a bayonet-shaped metal tube 3 inches long is convenient for these injec- tions as well as injecting the tonsils, 10 or even 20 minims may be required to produce complete anesthesia of the middle ear. For local anesthesia of the tonsils the same syringe answers every pur- pose. Moss, quoted by Ballenger, recommends a 4 per cent, solution of cocain diluted with an equal amount of a 1:2000 solution of adrenalin, 1 drop should be injected into the anterior and posterior pillars in the middle, above and below and into the supratonsillar space, with perhaps a drop or so in the tonsil itself; practically 10 drops for each tonsil. After the removal of one tonsil, inject the second in the same manner as the first. This equals about | gr. of cocain for both tonsils. Yankauer advocates injecting a few drops of a 1 per cent, solution of cocain into the neighborhood of the accessory palatine foramina, by which means the entire region supplied by the middle and posterior palatine nerves, including the tonsil, is anesthetized. The point of the needle is inserted obliquely through the mucous membrane to the bone at a point 1 cm. above and 1 mm. posterior to the posterior edge of the gum of the third molar, or should this tooth be absent, 1 cm. obliquely upward and forward from the tip of the hamular process. For the relief of earache and the production of sufficient local anesthesia for a paracentesis or the removal of an aural polypus Ballance advocates instilling into the ear a drop of the fluid resulting from the mixture of equal parts of carbolic acid, menthol, and cocain crystals. The resulting fluid is not caustic, as might be inferred from its composition, but the degree and duration of the anesthesia resulting from its instillation into the ear is inferior to that produced by Ballin's subcutaneous injections of cocain and adrenalin, and for the cocain in the formula may be substituted camphor with apparently equally good results as far as aleviating otalgia is con- cerned. Smilie states that corypfin is superior to the menthol-phenol- cocain formula for the relief of pain. Eucain, alypin, stovain, and several other substances have been offered as substitutes for cocain, the claim being that they possess anesthetic qualities similar to those of cocian and are less liable to produce toxic effects. In cases that are known to be sensitive to the toxic effects of cocain it would be well to employ one of these substances. The fact that neither alypin or stovain contract the tissues render them valuable anesthetics in operations upon posterior nasal hypertrophies. Hypodermic tablets can be obtained from manufactures containing suitable amounts of synthetical cocain and adrenalin to make solutions 538 DISEASES OF THE NOSE, THROAT, AND EAR for either surface applications or hypodermic injections. These syn- thetical products are said to be less toxic than cocain and adrenalin and equally satisfactory for producing local anesthesia. The symptoms of cocain poisoning are rapid and shallow respiration, feeble or absent pulse, mental anxiety, restlessness and finally unconscious- ness. Death may occur from asphyxia after feeble respirations of the Cheyne-Stokes type. According to Engstad the inhalation of ether by the drop method up to mild anesthesia is the most prompt and effective antidote. Ether at first stimulates the vasomotor system, is a tonic to the heart muscle and increases the pulmonary circulation. ASTRINGENTS Astringent sprays for the nose, pharynx, and larynx of zinc and copper sulphate, alum and zinc sulphocarbonate may be used of a strength of 5 to 10 gr. perchlorid of iron, nitrate of silver, and tannin in the strength of 3 to 5 gr. per ounce to decrease congestion and lessen secretions. Usually zinc sulphate yields the best results. Alum has been a favorite for a long time, but its use as an astringent spray for the larynx has been superseded to a considerable extent by alumnol, which is less irritating and can be used in strengths of 10 to 20 gr. to the ounce. Astringent sprays are not fre- quently employed in the nose and should be used after cleansing the nasal mucous membrane with a detergent. The astringent is best dissolved in oil or, better still, used as an ointment by the patient, who should throw his head well back and retain it in that position until by gentle sniffing the ointment melts its way through the nasal passages and is hawked into the mouth and expectorated. If preferred, the astringent may be incorporated with cocoa-butter and employed as a nasal suppository. 12. I|. Zinci sulphatis, gr. x-xx; Glycerini, f 3 ij; Aquae, q. s. ad. f 3 j.-M. Useful as an application by means of a brush or a dossil of absorbent cotton to the pharynx and larynx in subacute and chronic laryngitis, and to the nasopharynx in subacute nasopharyngeal catarrh. 13. I|. Tincturae ferri chloridi, Glycerini, aa fgss.-M. Useful as an application to erosions over varicose vessels in chronic nose- bleed. 14. 1$. Acidi gallici, gr. v-x; Petrolati, 3j.-M. Sig.-For patient's use in recurrent nasal hemorrhage and in the chronic rhinitis of children. A piece the size of a pea should be inserted in each nostril night and morning. 15. I). Pil. atropiae sulphatis, gr. Sig.-One every three or four hours. Useful in controlling excessive nasal secretion in coryza, hay-fever, and nasal hydrorrhea. FORMULAS 539 i6. Alcohol, 95 per cent. Useful as an application to the tympanic mucous membrane when it is covered by granulations and small polypi. For the patient's use at home, to cause shrinking of granulations and polypi, alcohol, diluted with an equal amount of water, may be prescribed, to be dropped into the auditory canal several times a day. Should this cause only momentary smarting, the patient should on the next occasion use alcohol 2 parts diluted with water 1 part, and so on until undiluted 95 per cent, alcohol is dropped into the ear four or five times a day. Practically the ear will then contain alcohol all the time. It acts as a dehydrating agent on polypi and exuber- ant granulations, destroying their vitality and promoting cicatrization. Its value as an antiseptic also plays its part in bringing about a good result. Boric acid dissolved in the alcohol is sometimes prescribed for the patient's use, but, as under such circumstances when the alcohol evaporates the boric acid is deposited as sharp-pointed crystals on the mucous membrane, it is probable that the boric acid is a source of irritation. The same may be said to a less degree of the addition to the alcohol of other dehydrating agents like glycerin and sulphuric ether. In order to secure the best results from instillations of alcohol the patient should lie down with the affected ear uppermost and then straighten the canal by pulling the auricle upward, outward, and backward. The canal should then be filled with alcohol, which should be forced into the tympanum by manipulating the tragus. This procedure also serves to float outward particles of pus and other materials. Polypi of considerable size may be destroyed by this method, but it is somewhat tedious if the polypi are large, and hence such growths should be removed by snare or forceps. Alcohol is also a valuable antiseptic and astringent in the treatment of inflammation of the accessory sinuses, pharynx and larynx. In the accessory sinuses it is used in the same manner and with the same precautions as in the middle ear. 17. Liq. argenti nitratis, 2 to 20 per cent. Silver nitrate (10 per cent.) is useful as an application to the pharynx or tonsils in acute pharyngitis or tonsillitis. When applied sufficiently early it will often abort the disease if used two or three times a day. When painted upon the lateral walls of the pharynx it produces at once a feeling of relief and comfort which persists for some time; when painted upon the posterior wall of the pharynx, a sensation of dryness and great discomfort. Hence it should not be used in this portion of the pharynx except for touch- ing small areas of granulation tissue, etc. However, 2 per cent, solutions are permissible. Solutions of silver nitrate (20 per cent.) also may be used as an astringent application to small polypi and exuberant granulation tissue in the tym- panum. However, for this purpose it is far inferior to strong alcohol. Even the solid stick of silver nitrate when applied to granulations in the ear produces only a superficial destruction of tissue, and in this respect is far inferior to chromic or trichloracetic acids. 18. Protargol. 19. Argyrol. The above are two of the best of the organic compounds of silver. Of the two, argyrol is probalby the more valuable in controlling inflammations of mucous membranes. Protargol may be used as a spray to the pharynx 540 DISEASES OF THE NOSE, THROAT, AND EAR or larynx in 10 per cent, solutions and argyrol in 20 per cent, solutions. Neither stain the skin, but each produce ugly stains of linen, that of argyrol being easily removed by soaking in bichlorid solution. They stop up atomizer tubes somewhat quickly, and hence are not well adapted for patients' use at home. Protargol and argyrol, when applied to mucous membranes, are somewhat astringent antiseptics, are nearly devoid of the irritating effects of silver nitrate, and penetrate the tissues more deeply. Argyrol in 5 per cent, solution is especially serviceable in the recurrent attacks of otorrhea where the drum-head has been destroyed. If applied at an early stage of the. attack a single application by means of a cotton- tipped probe will sometimes abort the disease. If more than one applica- tion is. required, it should be repeated every day. It is valuable as a non- irritating antiseptic injection by means of Blake's cannula into the attic of the tympanum in attic otorrhea, often bringing about a cessatiomof the discharge. 20. Tr. benzoini comp. Formerly, the compound tincture of benzoin was somewhat popular as an application to the nasal mucous membranes, either full strength or diluted with an equal amount of glycerin as a mild antiseptic astringent and deodorizer. Gauze moistened with the tincture will remain for sev- eral days within the nose without becoming fetid. The odor of a foul- smelling otorrhea can be corrected by mopping the canal and middle ear dry and applying compound tincture of benzoin every two or three days. ALTERATIVES 21. I). Hydrargyri bichloridi, gr. j; Potassii iodidi, 3 ij; Aquas, fgiij.-M. Sig.-i to 3 teaspoonfuls after meals. This formula, sometimes called " i, .2, 3 mixture," may be ordered when it is desired to employ the mixed treatment in syphilis. "lodid of potassium and sodium are very diffusible and are rapidly ex- creted, setting free nascent oxygen and iodin at the points of elimination. They are remotely irritant to the mucous membrane. They induce great waste and rapid elimination of waste products, causing anemia, emacia- tion, and depression. Mercury salts in small doses are blood tonics, improving the. general condition, increasing the number of red corpuscles and body weight. They soon, however, begin to promote waste by stimulating the lymphatic system." (Wilson.) 22. 3. Tablet triturat. hydrarg. protiodidi, gr. Sig.-1 tablet may be taken three or four times a day or even oftener, with a sufficient quantity of opium, if necessary, to prevent diarrhea. Useful in the treatment of primary and secondary syphilis. 23. Salvarsan is a name given by its discoverer Ehrlich to an arsenical compound, probably the most active and speedy antisyphilitic known. In some primary cases a single injection has apparently brought about a cure. During the secondary and tertiary periods relapses are the rule and injections should be repeated as required. In some tertiary cases the FORMULAS 541 results are inferior to those obtained by mercury and iodid of potassium; but in most instances a single injection has aproximately the same result as four or five months treatment by other methods. As salvarsan is highly poisonous the technique should be thoroughly mastered before attempting to use it. 24. 1$. Bichlorid of mercury, gr. viij; Phenol (carbolic acid), Tfiviij; Physiologic salt solution, §j.-M. The above is the original formula of Dr. E. C. Hay, who states that the average dose is 15 to 30 minims (1 to 2 cc.) every other day. Heidingsfeld injects deep into the gluteal muscles 2 to 3HI of equal parts by weight of metallic mercury and pure hydrated wool-fat. The ingredients should be thoroughly rubbed together, but not sterilized by heat. 25. I|. Syrupus acidi hydriodici (N. F.). Containing 1 per cent. HI by weight. Prepared from diluted hydriodic acid, it is of definite strength and does not readily decompose if properly protected against the atmosphere and the light. Sig.-4 cc. or 1 fl. dr. in a wineglassful of water after meals. Alterative, substitute for the alkaline iodids. 26. I). Hydrargyri cum cretae, Sig.-1 to 4 gr. three times a day. Gray powder is sometimes useful in the treatment of infantile syphilis. In a small proportion of cases mercury or iodid of potassium produce a violent reaction, the syphilitic lesions, for the time at least, being rendered worse instead of better by the exhibition of these drugs. Other cases, because of the disturbance of the gastro-intestinal tract, cannot tolerate either the iodids or mercury. Such cases generally do well on the follow- ing prescription: 27. Dionin. Dionin has been used by Randall and others to stimulate the circulation in middle ear catarrh and thus aid the absorption of scar tissue, cicatricial bands, adhesions, etc. One or two minums of a 2 to 4 per cent, solution should be blown through a Eustachian catheter by means of a Politzer bag. The fluid enters the Eustachian tube as a coarse spray, some of which when the tube is dilated in the advanced stages of middle ear catarrh, reaches the tympanum. Congestion of the drum head indicates that the remedy has reached its goal. Improvement as regards hearing and tinnitus appear after several applications which are repeated at intervals of three or four days. As the sedative dose of dionin by the mouth is about 7 grains, it is a comparatively safe drug to use in the manner described. It sometimes causes trancient vertigo as any watery solution would do if blown into the middle ear through a catheter. In Randall's practice twenty appli- cations complete the course; which after an interval may be repeated. 28. I). Thiosinamin. Favorable results are reported from this remedy as a resolvent in chronic catarrh of the middle ear in doses of gr. | to two or three times a day. 542 DISEASES OF THE NOSE, THROAT, AND EAR It is said to promote the absorption of newly formed fibrous tissue and hence relieve tinnitus and improve the hearing. It is given in capsules or tablet triturates; or hypodermically, 1 or 2 gr. every third day. With the exception of the galvanocautery the caustics most employed in rhinology and otology are chromic and trichloracetic acids. As the de- struction of tissue produced by applications of even the solid stick of nitrate of silver is very superficial, it scarcely can be considered a caustic. Battey's solution is sometimes used as a mild caustic to destroy hyper- trophied follicles in follicular pharyngitis. The formula is as follows: 29. 1$. lodin resublim., gr. clx; Phenol, gr. ccxl; Gly cerini, f 5 vj.-M. Owing to the anesthetic effects of the carbolic acid, simply touching four or five hypertrophied follicles gives little pain or subsequent uneasi- ness. The remedy may also be used to contract hypertrophied tonsils by wrapping a few fibers of cotton about the end of an applicator and after dipping in the solution passing the applicator to the bottom of a crypt or one or two drops injected into the crypt with a suitable syringe. Three or more crypts in each tonsil should be treated at intervals of a week or ten days. 30. 1$. Zinci chloridi, 5j; Aquae des til., 3j.-M. Useful in cauterizing the ulcers of malignant growths to secure healing or at least diminish pain and fetor. The application should be preceded by cocainization. Carbolic acid is sometimes used as a mild caustic to destroy granula- tions in the middle ear. Either the crystals, to which a sufficient amount of glycerin has been added to render them fluid, or one of Calvert's solu- tions may be applied by means of a cotton-tipped probe to the exuberant granulations. Care should be exercised not to apply any of the carbolic acid to the skin of the canal. After a few moments alcohol should be dropped into the ear to check further action of the acid and the parts mopped dry and boric acid insufflated. Various methods of employing trichloracetic acid and chromic acid as caustics have already been described in the text. CAUSTICS COUGH MIXTURES Although remedies designed to affect the respiratory tract are best administered by means of an atomizer or nebulizer, and when that is im- possible or inconvenient, in the form of a lozenge, yet the cough mixture still retains at least a measure of its former popularity. The following formulas are effective and sometimes convenient to prescribe: 31. 1$. 'Syrupi ipecacuanhas, f$ss; Syrupi scillae, f 3 vj; Liq. potass, citratis, . fgj; Mucil. acaciae, q. s. ad. f 3iij.-M. Sig.-A teaspoonful in water every three hours. FORMULAS 543 Useful for controlling the coughs of children. 32. T$. Ammonia bromidi, 3ss; Potassii cyanidi, gr. iss; Ext. pruni virginiani fl., f 3 ss; Ext. grindelia robusta fl., f3iij; Elixir adjuvantis, q. s. f§iv.-M. Sig.-A teaspoonful in water four times a day. Useful in the so-called "useless or dry cough" of nervous individuals due to pharyngeal irritation. 33. 1$. Morphina sulphatis, gr. ss-ij; Potassii cyanidi, gr. iij; Acidi sulphurici aromatici, f5j-ij; Syrupi pruni virginiana, q. s. ad. f§iij.-M. Sig.-A teaspoonful every two or three hours if required to prevent coughing. Useful as an anodyne, but somewhat stimulating cough mixture. 34. I}. Tinctura gelseminii, Tinctura lobelia, aa 5j; Potassii bromidi, 5 ss.-M. Sig.-20 drops in water every three hours. (Burnett.) The above is said to be almost a specific as regards relief in asthma. 35. 3. Elixir terpini hydratis cum codeina, N. F. 4 cc., or 1 fl. dr., representing 0.06 gm. (1 gr.) terpin hydrate, and 0.008 gm. (i gr.) codein. Sig.-A teaspoonful every three hours if required to prevent coughing. 36. 1^. Elixir terpini hydratic cum heroina, N. F. 4 cc. or 1 fl. dr., representing 0.06 gm. (1 gr.) terpin hydrate, and 0.0040 gm. (^ gr.) heroin. Sig.-A teaspoonful every three hours if required to prevent coughing. 37. I). Ext. grindelia robusta fl., f 3 j; Tinct. lobelia, Tinct. belladonna, aa f 3ij; Potassii iodidi, 3 iss; Syrupi, fgj; Aqua, q. s. ad. f§iv.-M. (Edwards.) Sig.-One teaspoonful four times a day in the treatment of bronchial asthma. CLIMATOLOGY All catarrhal diseases are favorably influenced by an atmosphere free from dust. This is especially true of atrophic rhinitis, where proximity to large bodies of water and consequent moist atmosphere exerts a favor- able influence. In chronic hypertrophic catarrh and bronchitis generally a dry atmosphere such as the sandy districts remote from large bodies of DISEASES OF THE NOSE, THROAT. AND EAR 544 water is beneficial. Usually such localities are covered by evergreen and not deciduous trees, so that the atmosphere is saturated with piney odors. It is probable that temperature, provided there are few sudden changes, does not exert a very decided influence, although excessive and long- continued heat is debilitating and very excessive cold discourages the remaining out of doors for long periods of persons not in robust health. The altitude of a locality and the consequent rarification or condensation of its atmosphere exerts a considerable influence. Tuberculous individ- uals are generally benefited by residence in places where the altitude is considerable, but where there are extensive lung lesions it is important that the change from ordinary to high altitudes should be made very gradually because of the danger of pulmonary hemorrhage and for other reasons. Dr. Guy Hinsdale gives the following list of popular resorts as favorable for the treatment of diseases of the upper respiratory tract: Chronic Catarrh of the Pharynx, Larynx, and Nose.-Summer: The Long Island and Massachusetts coast; the interior resorts of Maine, Moosehead Lake, Rangeley Lakes, Poland Springs; the White Moutains of New Hampshire; the Adirondacks, N. Y.; Pocono Mountains, Eagles Mere, Kane, Pa.; the Virginia Springs, the mountains of West Virginia and North Carolina; the southern coast of California, San Diego, Coronado, Santa Barbara; Castle Hot Springs, Arizona; Honolulu, Nassau. Hay-fever.-The highlands of Ontario, comprising the Muskoka Lakes, the Lake of Bays, the Magnetawang district, Penetag, Midland, Honey Harbor, Georgian Bay, and Kawartha Lakes; Port Arthur and the neigh- borhood of Thunder Bay, Lake Superior; Yarmouth, Nova Scotia; Cape Breton; Charlottetown, Prince Edward Island; St. Andrews, Digby, Dal- housie, Campobello, New Brunwick, Eastport, Vinal Haven, Isle au Haut, Katahdin Iron Works, Moosehead Lake and Rangeley Lakes, Maine; Bethlehem, Maplewood, Profile, Twin Moutain, Mount Pleasant, Fabyans, Crawford, Jefferson, Dixville Notch, N. H.; the Isles of Shoales, N. H.; Baker Island, Rock Island, Nantucket, Mass.; the higher Adiron- dack resorts, e.g., Undercliff, Ruisseaumont and Whiteface, Lake Placid; Ampersand, Saranac Lake; Paul Smith's, Blue Mountain Lake, Raquette Lake, and Loon Lake; Beach Haven, N. J.; Put-in-Bay, Ohio; Marquette, Sault Ste. Marie, Mackinac, Mich.; Coronado Beach, Catalina Island, Cal. Asthma, the Neurotic or Spasmodic Form.-Elevated sunny regions, e.g., Colorado Springs, Manitou, Glenwood Springs, Colo.; Castle Hot Springs, Ariz.; Hot Springs, Va.; Lake Placid, N. Y.; the White Mountains, N. H.; Kane, Pa. The higher elevations are counterindicated in aged persons. Tubercular Laryngitis.-Florida and Southern California. Chronic Fibroid Phthisis.-The interior Florida resorts in winter; the sand belt of Georgia, South Carolina, and North Carolina. The coast resorts of the southern Atlantic seaboard, including Atlantic City, are suit- able for selected cases. Pidmonary Tubercidosis.-Gravenhurst, Ontario; Lahl Ghur, Ste. Agathe, Quebec; Long Lake, Gabriels, Ray Brook, Saranac Lake, Paul Smith's, N. Y.; Liberty, N. Y.; Rutland, Mass.; Sharon, Mass.; East Bridgewater, Mass.; New Canaan, Conn.; South Scituate, R. I.; Lake- wood, Hammonton, Vineland, N. J.; Kane, Glen Summit, Pocono, Mont Alto, White Haven, Penna.; Ashville, N. C.; Southern Pines, N. C.; Aiken, Camden, S. C.; Thomasville and Summerville, Ga.; Palatka, Enterprise, Fla.; San Antonio, El Paso, and Western Texas; Santa Fe, FORMULAS 545 Las Cruces, Las Vegas, Hot Springs, Fort Bayard, Fort Stanton, Silver City, and Albuquerque, New Mexico; Colorado Springs, Denver, Estes Park Cannon City, Boulder, Colo.; Phoenix, Tucson, Tempe, and Prescott, Ariz.; the interior resorts, such as Redlands, Riverside and Idyllwild, near San Jacinto Mt., Monrovia, Pasadena, Mentone, Esparanza, Altadena, Santa Barbara, San Diego, Southern California; in summer the Rocky Mountains of Idaho, Montana, and British Columbia. In cases compli- cated with kidney disease, and in any advanced stage, high altitudes should be avoided, but hemorrhage is not a counterindication. GARGLES Gargles are of little value unless employed with more than usual care. Pope, by means of experiments with methylene-blue and other substances, demonstrated that as ordinarily performed gargling does not bring a medicament in contact with the fauces further back than the anterior pillars. When necessary to prescribe a. gargle the patient should be instructed to close the nose tightly, throw the head far back, and gargle. By this method the probability of the fluid reaching the posterior wall of the pharynx is increased. Children cannot use a gargle, and rarely is it practical to teach a patient to gargle properly during an office visit. Gargles as ordinarily employed rarely reach the posterior wall of the pharynx and never the larynx. However, the following are cheap as- tringent gargles, and they may at some time be convenient to prescribe. The small amount of the gargle swallowed is, of course, effective. 38. R. Glycerol tannici, 3j. Sig.-A teaspoonful in a half-tumbler of water. Use as a gargle. 39. R. Alcoholis, 95 per cent. Sig.-Use as a gargle. 40. R. Acidi tannici, Acidi gallici, aa gr. xx.-M. Sig.-Add to a tumblerful of iced water. Gargle and swallow a portion every few moments until the hemorrhage ceases. As a styptic after tonsillotomy to control oozing of blood. 41. 1$. Hydrogen dioxid, 15 volumes (3 per cent.). Sig.--Use as a gargle to control oozing of blood after tonsillotomy. HEMOSTATICS 42. Adrenalin. Adrenalin is the active blood-pressure-raising principle obtained from the suprarenal capsule of beeves or sheep. Epinine is a synthetic compound having similar properties to adnephin and its solutions can be sterilized by boiling. These substances are usually sold in i :ioo solution, containing an antiseptic to prevent decomposition. For this reason adrenalin is prepared by some manufacturers in tablets, one or which dissolved in 15 minims of water yields a 1 :iooo solution. The solutions prepared by dis- solving one of the tablets contains no antiseptic to irritate the nose, and 546 DISEASES OE THE NOSE, THROAT, AND EAR for this reason is somewhat better in the treatment of hay-fever and other conditions where the nasal mucous membrane is irritable. In the same class of cases the drug dissolved in albolene yields better results than a watery solution. To produce local ischemia in mucous membranes preparatory to a surgical operation a i: rooo solution is generally employed. The best results are obtained by applying pledgets of cotton within the nose saturated with 1:1000 solution. After ten minutes a saturated solution of cocain is gently rubbed into the parts by means of a cotton- tipped applicator that has first been dipped into a cocain solution, and then, after pressing out the drip, into a bottle of coarsely powdered cocain crystals. When used in this manner nasal operations can be done without the loss of a drop of blood unless a vessel of considerable size be encountered. However, secondary hemorrhage occurring one or two hours after a nasal operation is more common when adrenalin has been employed, because the ischemia of mucous membranes so produced is followed by congestion when the effects of the drug have passed off. The fact that applications of adrenalin to the nasal mucous mem- brane are followed by congestion as soon as the effects of the drug have passed, prevents the remedy being entirely satisfactory in the treatment of hay-fever. The best results are obtained by somewhat frequent applica- tions, say once in two or three hours, of a solution not stronger than i: 5000 or 1:10,000 or one of the oily preparations of adrenalin. However, in spite of every precaution, after a few days the condition of a hay-fever patient using local applications of adrenalin is in nowise improved, and is usually worse, At best it gives only temporary relief. In some cases where even weak solutions of adrenalin are employed to prolong the effects of cocain, symptoms resembling atropin-poisoning occur. The nose is greatly congested and occluded. There are frequent attacks of sneezing and both nose and throat are hot and dry. To pro- long the ischemic effects of cocain, antipyrin is safer than adrenalin. The effects of adrenalin on the heart are similar to those of digitalis, with the difference that it acts with great rapidity, its effects are not as prolonged, and the blood-pressure-raising effect is more apparent. It slows the pulse and strengthens the cardiac systole while it shortens and renders diastole less perfect. It is a valuable cardiac stimulant and may be used hypodermically in heart failure during chloroform anesthesia. Adrenalin is usually classed among the alkaloids because it is a nitrogenous compound forming salts with acids. It probably exists in the suprarenal capsules in combination with some organic acid. It is decom- posed by prolonged contact with alkalis and, therefore, should not be prescribed in conjunction with an alkaline nose-w'ash. It is a reducing agent and, therefore, should not be used in conjunction with hydrogen dioxid, permanganate, etc. It attacks many metals, tarnishing them and producing a black precipitate, therefore adrenalin solutions should not be allowed to remain of any great length of time in atomizers with metal tubes. 43. 3- Acidi tannici, Acidi gallici, aa gr. xx.-M. Sig.-Add to a tumblerful of water and slowly sip the mixture, or gargle and swallow a portion every few moments until the bleeding stops. Useful in controlling oozing of blood from the wound after tonsillectomy. FORMULAS 547 44. I|. Ergotin. (aq. ext.), 5j; Ext. hyoscy. ale., gr. iij.-M. Ft. cap. No. xx. Sig.-One every three hours in hemoptysis. 45. I). Acidi gallici, 5iss-iij; Vini rectif., gss; Glycerini, giiiss.-M. Sig.-A teaspoonful every two hours in hemoptysis. 46. 1$. 01. terebinth., gj; Muc. acaciae, 5iij; 01. gaultheriae, Tffij.-M. Sig.-A teaspoonful every hour with water in hemoptysis. 47. 1$. Calcii chloridi, gr. xl. Ft. cap. No. viii. Sig.-One every hour until the bleeding is controlled. The effects of calcium chlorid is to increase the coagulability of the blood, but if too large a quantity of the drug is given the opposite result is caused, namely, diminished coagulability. On this theory 2 or even 3 capsules (10 to 15 gr.) may be given at intervals of an hour in severe cases, but the amount of 80 gr. should not be exceeded in as many hours. Even in cases where the hemorrhage has not been completely controlled, if 80 gr. have been given within eighty hours, it is best to wait several hours before again resorting to the drug. However, in nasal hemorrhage resulting from diminished coagulability of the blood, better results follow the injection of 10 to 30 cc. of horse serum. 48. 1$. Trional, gr. x-xxx. 49. ij. Sulphonal, gr. x-xxx. 50. 1$. Paraldehyd, . fgss; Olei gaultheria;, Tffx; Pulveris acacia;, o ij J Elixir simplicis, q. s. ad. f§iv.-M. Sig.-J to 1 tablespoonful in water every hour or two in the restlessness and insomnia following mastoid operations. 51. 1$. Chloral hydratis, gr. x; Codein sulphatis, gr. Strychninse sulphatis, gr. -M. Ft. chartae No. i. Sig.-To relieve restlessness and insomnia after mastoid operations. Dissolve in half-tumberful of water and repeat dose in three hours if necessary. After many severe operations on the nose, throat, or ear the patient for the first night or two will complain of pain, restlessness, and inability to sleep. This is especially true in neglected mastoid cases that have been operated on only after weeks of needless suffering and consequent demor- alization and debility. In some such instances a hypodermic of | gr. of morphin will be required in order to soothe the patient's sufferings. In other cases a reliable hypnotic produces the desired results. Under such HYPNOTICS 548 DISEASES OF THE NOSE, THROAT, AND EAR circumstances the choice of a hypnotic in the patient's debilitated condition is by no means a matter of indifference, as all hypnotics are to a greater or less degree depressants. Sodium bro mid (10 gr.) combined with chloral (5 gr.) repeated every hour, if necessary, yielded good results in the prac- tice of the writer for several years. More recently, however, he has relied either on Formula 50 or 51. It should be observed that any possible depressant effect of chloral on the heart is guarded by the addition of a small proportion of strychnin in Formula 51. HAY-FEVER 52. 3. Pulv. salis Vichyani fact, efferv. (N. F.), 3iv. Sig.-Take a teaspoonful in a glass of water four times a day. Or, if the action of lithium is desired, the pulvis salis Vichyani factiti effervescens cum lithio (N. F.) may be prescribed. 53. 3- Hyoscin® hydrobromatis, gr. T^; Camphor® monobromat®, gr. ij; Sacchari lactis, q. s.-M. Misce et tritura bene. Divide in tabulas vel capsulas No. xx. Sig.-1 tablet or capsule at intervals of from ten to ninety minutes until the sneezing and running of the nose are controlled, after which 1 tablet may be taken every second, third, or fourth hour, as may be necessary to maintain the effect. The following may be given in the same way: 54. I). Atropin® sulphatis, gr. ^4; Camphor® monobromat®, gr. v; Balsami peruviani, q. s.-M. Misce. fac. capsul® No. xx. Dr. H. H. Curtis, recommends the following tablet: 55. T^. Strychnin® arsenatis, gr. f; Atropin® sulphatis, gr. Camphor®, gr. xxv; Ipecacuanh®, gr. v.-M. Fiat massa in pilul® No. c dividenda. Sig.-One pill from three to six times a day. 56. 1$. Heroin, gr. j; Atropin® sulph. gr. tj'j; Caffein cit., gr. xv; Salophen, gr. Ixxv.-M. Ft. caps. No. xv. Sig.-One every two hours until 3 or 4 are taken and the nasal symptoms are alleviated, then 1 every three or four hours. 57. 3. Menthol, gr. j; Cocain® hydrochlor., gr. j; Orthoform, gr. v; Petrolati albi, 5j--M. Sig.-Apply to the nasal mucous membrane every two or three hours in acute rhinitis or hay-fever. FORMULAS 549 58. 1$. Acidi nitromuriatici (concentrated, freshly prepared), fg j Sig.-5 to io drops in a tumberful of water one hour after meals and at bedtime. In a proportion of cases of hay-fever the above formula will eliminate all symptoms of the disease within forty-eight hours. If after two or three days' use of the remedy there is no improvement in the symptoms, it is probable that nitromuriatic acid will prove useless, no matter how long continued. Mineral acids in the treatment of hay-fever are said to owe their effi- ciency to the fact that they diminish the alkalinity of the blood to an extent that it is no longer capable of holding in solution uric acid, and hence the mucous membranes are not irritated by the secretion of this substance. However, nitromuriatic acid has been employed for several generations as an alterative and tonic in gastro-intestinal diseases and in diseases of the liver, where it is said to increase the biliary secretions. It is probable, therefore, that when exhibited in the treatment if hay-fever that it not only frees the blood from uric acid but also, by improving metabolism, limits the formation of uric acid and perhaps other products of defective metabolism. Mineral acids were formerly used more frequently than at present in the treatment of diseases of the upper respiratory tract, io drops of dilute nitric acid every two hours in water beng an old but usually effective remedy in the treatment of the aphonia of singers and orators. The use of nitromuriatic acid may be commenced at any time before or during the hay-fever season. It is important that the acid be freshly pre- pared. At first a colorless liquid, it becomes within a few days yellow. The yellow color deepens almost to brown, but finally again becomes lighter, until at length the mixture is colorless. During this period of change in color fumes are given off a:nd the remedy is then thought to be most active in its effects upon the gastro-intestinal tract. When io drops are diluted with a tumblerful of water the water is only slightly sour to the taste, but is is well enough as a precaution against possible injury to the teeth to rinse out the mouth either with pure water or water to which a pinch or two of baking soda has been added. If the use of nitromuriatic acid is successful in eliminating the symptoms of hay-fever, it is probable that they will cease to recur as long as the patient continues to take the remedy regularly. However, should he neglect to take a single dose, more especially the evening dose, it is prob- able that some symptoms of the disease will be quickly manifested. For example, if the evening dose be omitted, it is probable that the patient will wake up the next morning with his nose occluded and irritable and very likely will have several attacks of sneezing. Prolonged use of nitromuriatic acid is apparently harmless. Some of the writer's earlier cases have used the acid for months at a time year after year during the hay-fever season, and occasionally some of them during the winter season as well, without noticing any deleterious effects. In cases where the remedy is effective it is curative to the extent that it almost completely controls the symptoms during the hay-fever season, and there seems a tendency for the attacks to become less and less severe from year to year. In neurotics suffering from hay-fever much benefit sometimes results from: 550 DISEASES OF THE NOSE, THROAT, AND EAR 59. I). Acidi hydrobromici diluti, f 5 ij. Sig.-15 to 30 drops in a tumblerful of water one hour after meals. Hydrobromic acid also yields in a majority of cases somewhat better results in the treatment of tinnitus than bromid of sodium or the mixed bromids. FORMULAS FOR THE BOTTLE INHALER, CROUP KETTLE, ETC. The steam from a kettle containing unslaked lime has been used for many years in the treatment of croup and diphtheria. A croup kettle consists of a vessel usually with a long spout, to which a rubber hose is attached, by means of which steam is conveyed to the vicinity of a patient or under a croup tent erected over a bed. As the quantity of unskaled lime that will dissolve in water is not great, a piece of lime the size of a walnut is more than sufficient for several quarts of boiling water. The following formula may be used with the bottle inhaler or added to the water in a teapot containing boiling water. 60. 3. Tr. benzoin comp. Sig.-Add | teaspoonful to a bottle inhaler half-full of hot water. Use the inhaler four or five times a day. Useful in most forms of laryngeal inflammation. To the above formula, when requisite, an expectorant-ammonia muriat., fluidextract of senega, or ipecac-may be added. When it is desired to diminish expectoration and at the same time produce a sedative effect upon the laryngeal mucous membrane, fluidextract of belladonna or hyoscyamus in combination with the compound tincture of benzoin will yield satisfactory results. 61. I). Creosoti, Alcoholis, aa fgj.-M. Sig.-6 or 8 drops on the sponge of a perforated zinc inhaler every hour or two. Where there is much irritating cough, 30 per cent, of chloroform may be added to the formula. The zinc inhaler should be worn upon the face as much as possible both day and night. LOZENGES Lozenges, when well made, are superior to cough syrups or gargles for the treatment of throat affections. They should be so made as to dissolve slowly and evenly in the mouth, thereby giving a more prolonged local FORMULAS 551 effect than is possible with gargles or a spray, and a quicker and more pronounced result than can be obtained by a greater quantity of the medicant introduced into the stomach. The favorite excipients seem to be black-currant paste and gelatin. Because of the length of time required for the drying of lozenges, druggists cannot quickly make them from the prescription of a physician, and it is, therefore, better to rely on the manufactured product of lozenge-makers, some of whom have national or international reputations. A business man can carry a bottle of lozenges in his vest pocket and take one as required from time to time, when he would be embarassed by the use of an atomizer. However, it should be remembered that lozenges produce both a local and a constitutional effect and are only especially useful when this effect is desired. Lozenges have in common with cough mixtures a notorious reputation or disordering the stomach. Most of the following formulas have been selected from the stock lozenges of manufacturers. "In cases of deep tonsillitis there is, fortunately, a remedy which if ad- ministered at the outset of the attack, will almost always cut short the crescent inflammation. This is guaiacum. I prescribe it as a lozenge. Taken in this way it seems to have a local as well as a constitutional effect." -Morell Mackenzie. 62. 1$. Troch. guaiac. The lozenges are stimulant and alterative, and are capable of arresting recent inflammation of the tonsils. These lozenges should contain 2 gr. of the resin of guaiacum and made in accoordance with Mackenzie's formula, so as to be entirely soluble in the mouth. They are useful in the treatment of acute and subacute inflam- mation of the pharynx and acute follicular disease of the tonsils. 63. Troch. guaiac, comp. 3. Resin guaiac., gr. i j; Potassii iodidi, gr. j.-M. (Wm. Pepper.) Stimulant and alterative; is especially useful when in acute inflamma- tions of the tonsils there is a sensation of dryness, as the iodid increases secretion. A lozenge may be used every one or two hours. 64. Troch. guaiac, et acidi tannici. T|. Resin guaiac., gr. iss; Acidi tannici, gr. |.-M. Sig.-A lozenge to be dissolved slowly on the tongue every one or two hours. Stimulant and astringent, probably the most useful of the guaiacum GUAIACUM AND ITS COMBINATIONS 552 DISEASES OF THE NOSE, THROAT, AND EAR lozenges in acute and subacute inflammation of the tonsils, pharynx, and larynx. Useful in the so-called "relaxed throats" of public speakers. The astringent action of the tannic acid is assisted by the alterative effect of the guaiacum. 65. Troch. guaiac, and benzoic acid. I). Resin guaiac., gr. ij; Acidi benzoici, gr. j.-M. (J. F. Martenet.) Stimulant in nervomuscular weakness of the throat. It is somewhat useful in the treatment and the loss of control of the laryngeal muscles experienced by nervous actors, singers, and orators. In addition to the lozenge, fa gr. of strychnin or 1 dram of fluidextract of cocoa in 1 ounce of sherry wine may be prescribed, to be taken a few moments before going upon the stage or platform. CAMPHOMENTHOL AND ITS COMBINATIONS 66. 1$. Troch. camphomenthol, gr. fa. Sig.-A lozenge to be dissolved on the tongue every one or two hours, as required. These lozenges check excessive discharges, and liquefy tenacious mucus. They are sedative, an antiseptic tonic to catarrhal conditions of the mem- brane, and a voice stimulant. 67. Troch. camphomenthol et eucalypti. 1$. Eucalyptus rostrate (red gum), gr. j; Camphomenthol, gr. fa.-M. Sig.-A lozenge to be dissolved on the tongue every one or two hours, as required. A pleasant antiseptic astringent and sedative. When greater anodyne effect is desired, in acute or chronic bronchitis, and in grip cough, the following is an efficient and reliable sedative: 68. Troch. codein comp. Codeinae, gr. Camphomenthol, gr. fa.-M. Sig.-A lozenge to be dissolved slowly on the tongue every one or two hours. 69. Troch. heroin. I). Heroin, gr. Camphomenthol, gr. /j.-M. Sig.-A lozenge every two hours if required to relieve cough. 70. Troch. orthofdrm comp. I|. Orthoform, gr. j; Camphomenthol, gr. fa.-M. Sig.--One ten minutes before meals or as required, as a safe analgesic after throat operations and other painful conditions of the pharynx and larynx. (McConachie.) FORMULAS 553 Instead of the orthoform lozenge, either of the two following may be employed in the dysphagia of tuberculous laryngitis, where greater anal- gesia is required: 71. Troch. cocain comp. I). Cocain hydroch., gr. Extract, hyoscyami, gr. fa Extract, opii, gr. Tincturas aconiti, Hiss.--M. Sig.-A lozenge a few moments before eating and every two or three hours. J. J- Chisholm.) This combination is of considerable value as an anesthetic and anodyne in the laryngeal lesions of phthisis and to control the paroxysms of asthma. COCAIN AND ITS COMBINATIONS AMMONIUM SALTS AND THEIR COMBINATIONS Ammonium salts have long been used in the treatment of pharyngitis and bronchitis. They may be given in the form of a lozenge for the local effect on the pharynx, but the lozenge should be so made that the ammo- nium salts do not dissolve more rapidly than the other ingredients of the lozenge. 72. Troch. glycyrrhiza comp. Sig.-A lozenge every two or three hours. Brown mixture lozenges should be so made that each lozenge corre- sponds to a teaspoonful of the well-known "brown mixture." 73. Troch. ammonias iodidi comp. I|. Ammonias iodidi, gr. j; Ammoniae chloridi, gr. ij; Codeinae, gr. f; Morphinae acetatis, gr. Ext. prunis virginianae, q. s.-M. Sig.-One every three hours as an alterative, sedative, expectorant. (Hayes.) MISCELLANEOUS LOZENGES Some of the prescriptions under this heading are old favorites and have been popular with many physicians for years. The next three lozenges may be given to children and adults who strenu- ously refuse any remedy having an unpleasant taste, as they are a pleas- ant confection: 74. Troch. mucilag. ulmi (mucilage of slippery elm). 3. Mucilag. ulmi, q. s. facio troch. No. i. 75. 1$. Ipecacuanha. These are large gum-arabic pastils of the same strength as the lozenges of the British Pharmacopoeia. They are readily taken by children and 554 DISEASES OF THE NOSE, THROAT, AND EAR exert the expectorant effects of ipecacuanha with the demulcent character- istics of the lozenge. 76. Troch. acidi borici composite. I|. Acidi benzoici, gr. ss; Acidi borici, gr. j; Ext. erythrox. cocas, gr. iss.-M. Fiat troch. No. i. (Faulkner). This lozenge is sedative, demulcent, and of a pleasant taste. It is a valuable voice lozenge in cases of orators and singers of the neurotic tem- perament, who dread that their voice will fail them in the presence of an audience because of nervous muscular weakness. One should be slowly dissolved in the mouth every four hours. When used as a "voice lozenge" one should be taken one-quarter of an hour before using the voice and fluids should be avoided. 77. Troch. acidi carbolici. I). Acidi carbolici, gr. j. Fiat troch. No. i. (Morell Mackenzie.) This formula has long been a favorite as an analgesic, antiseptic lozenge. MISCELLANEOUS 78. Contractile collodion. Contractile collodion is sometimes applied to a cicatricial or atrophic drum-head to hold it in a more favorable position for hearing. For this purpose, after inflation by Politzer's method, only a small amount of the collodion should be painted upon the drum-head at one time, as there is some danger of producing myringitis if too large an amount of the remedy is painted on the drum-head at one sitting. 79. Phosphorated oil. Formerly many ointments and solutions were applied to the membrana tympani for the relief of tinnitus and deafness caused by catarrh of the middle ear. Although this form of medication has largely been aban- doned, phosphorus dissolved in olive oil, if applied to the drum-head, will sometimes bring about improvement of the hearing in deafness due to senility. 80. Chloroform. 81. 3- lodin. 82. 1$. Tincturae iodini, f5j; Chloroformi, fgj.-M. 83. Menthol. The vapor of these substances is sometimes used as an application to the mucous membrane of the middle ear. They should be preserved ready for use in wide-mouthed, glass-stoppered bottles, so that the Politzer air-bag can be filled with their vapor by placing the nozzle of the bag within the neck of the bottle while the bag is expanding. Ether and FORMULAS 555 chloroform vapor will sometimes penetrate into the middle ear through the Eustachian tube when it is impossible to inflate the middle ear with simple air by Politzer's method or the use of the catheter. 84. 1$. Ac. carbol., gr. xxx; Ammon, carb., §j; Pul. carbo, lig., 5j; 01. lavend., Tfixx; Tr. benzoin co., gss; Gum camphor, 5ij.-M. Sig.-Smelling salts for acute nasal catarrh. 85. I). Paraffin, giv; Albolene, gv.-M. Melt together in container surrounded by boiling water. Sig.-For use as a subcutaneous injection for the correction of nasal deformities, etc. For subcutaneous injections sterile paraffin, with a melting-point of 1120 F., is usually employed. When the melting-point is much higher than this, it is not readily forced through a long needle and does not as readily penetrate the spaces of the cellular tissue. When the melting-point is much lower than 112° F., paraffin behaves more like ordinary oil, per- meates the tissues more readily, and may enter a vessel and cause embolus. Ordinary commercial paraffin, whose melting-point is usually 128° F., may be reduced to a melting-point of 1120 F. by adding 5 parts of albolene to 4 parts of paraffin, the mixture sterilized by boiling it and its container in water, and preserved for future use. Thus prepared the melted paraffin should be drawn into a suitable syringe (Fig. 69), the nozzle of which is then closed with its screw cap. The syringe with the paraffin it contains and the necessary needle are then sterilized by boiling in water. The syringe and paraffin contained in it are then cooled in sterile water, the screw cap removed, the needle screwed in its place, and the instrument is then ready for use. 86. 3- Ext- cimicifugee racemosae, f^ij. Sig.-15 to 20 drops after meals and at bedtime. The above is sometimes useful in tinnitus. When effective its beneficial results are manifested within a few days. However, a rather large pro- portion of cases of tinnitus from chronic middle-ear catarrh are not benefited in the least by the use of cimicifuga. 87. I|. Atropinae sulphatis, gr. |; Acidi sulphurici aromatici, f 3 ij; Aquae rosae, q. s. ad. f 3 j.-M. Sig.-20 to 30 drops at bedtime, repeated if necessary. Useful in the night-sweats of phthisis. 88. B- Acidi carbolici, gr. iij; Pulveris camphorae, Resorcini, aa gr. xx; Acidi borici, gr. xxx; Unguenti zinci oxidi, 5 j.-M. Fiat unguentum. Sig.-Use twice a day as an external application in acne rosacea of the nose. 556 DISEASES OF THE NOSE, THROAT, AND EAR 8g. I). Pilocarpine hydrochloras, gr. Pilocarpin may be given hypodermically once a day in conjunction with potassium iodid three times a day by the mouth in effusion or hemorrhage into the labyrinth, tertiary syphilis, and traumatism involving the internal ear. The average dose of pilocarpin is about gr. hypodermically, but much larger amounts have been used with impunity. When administered for its action on the internal ear a sufficient amount should be taken to pro- duce profuse sweating or salivation. The remedy should be continued a sufficient number of days to produce the desired result, unless the patient becomes greatly prostrated by its continued use or it is manifestly unavail- ing. When no improvement is manifest after a week's use of the drug it should be abandoned. It rarely is of use except in acute cases. Pilocarpin is a drug whose action should be carefully watched, because serious and even fatal consequences have resulted from the injection of medicinal doses. Shoemaker cites a case where the patient suddenly expired after an injection of pilocarpin. In another case the same author states that the employment of | gr. was followed by profuse diaphoresis, salivation, lacrimation, a discharge from the nose, sickness of the stomach, difficulty in breathing, and a sense of cardiac oppression. Internal and external stimulation caused the symptoms to disappear. Atropin is a physiologic antidote to pilocarpin. Pilocarpin may be given by the mouth instead of hypodermically, but its effects are longer in manifesting themselves (fifteen to twenty minutes) and more uncertain. Politzer advises the injection of 6 to 8 drops of warm 2 per cent, solution through the Eustachian catheter into the Eustachian tube in sclerosis of the middle ear. Mendosa, in 3 cases, relieved urgent dyspnea from edema of the larynx by hypodermic injections of pilocarpin. 90. I). Tincture aconiti, TTlxxxvj; Aquas destil., fgiss.-M. Sig.-A teaspoonful in water every half-hour until three doses are taken; then every hour. Useful in tonsillitis when the fever is high. Should be used after thor- oughly evacuating the bowels with a saline. 91. I). Sodii salicylatis, Potassii citratis, aa gr. xx; Elix, adjuvantis, N. F., f^iij.-M. Sig.-Teaspoonful every two hours for a child of four years with tonsillitis. 92. 1$. Menthol, gr. xi| (0.75 gm.); Cocain, gr. iii| (0.25 gm.); Chloral, gr. ii| (0.15 gm.); Petrolatum, gr. lxv(5 gm.).-M. Ft. unguentum. Sig.-Ointment for neuralgia. Apply to the painful part and cover with a gauze bandage if the neuralgia is periorbital or hemicranial. 93. 1$. Hexamethelamin (Urotropin), 5iv.-M. In Capsule No. xxiv dividenda. Sig.-One capsule three or four times a day is a prophylactic in threat- ened septic meningitis. FORMULAS 557 According to John Hopkins Hospital reports after therapeutic doses a sufficient amount of urotropin appears in the cerebrospinal fluid to exer- cise a decided inhibitory effect on the growth of microorganisms; 30 to 60 gr. a day may be given in otic cases at the onset of meningeal symptoms. It is excreted also by the nasal and aural mucous membranes and may be given with advantage in commencing infections of these cavities. 94. The growth of epithelium over granulations is greatly facilitated by the application of Scarlet Red either as a powder or ointment, of from 5 to 10 per cent. The use of a 5 per cent, ointment very greatly hastens the healing after the radical mastoid operations when skin grafts are not employed. 95. I}. Tinctura Gelsemii, M. xv.-xx. Morse states that 15 to 20 drops of the tincture of Gelsemium taken internally will usually abort an acute coryza at once. The dose should not be repeated. 96. 1$ chromii sulphatis, 3ii M. In capsulae No. xxx dividends. Sig.-One after meals and at bed time. According to Echelberger and other chromium sulphate is a specific in simple hypertrophy of the thyroid gland. (Goiter.) OPHTHALMO-CUTANEOUS DIAGNOSTIC REACTIONS IN TUBERCULOSIS Technic and Course of the Cutaneous Reaction.-The skin is cleansed with green soap and alcohol. A space, the size of a dime, is then scarified as in ordinary vaccination and a 25 per cent, solution of Koch's old tuber- culin rubbed in. Control vaccinations of 5 per cent, glycerin and | per cent, carbolic acid (the strength of these substances in tuberculin) are also made, because in certain individuals irritation follows slight traumat- ism of the skin. The positive reaction is manifested within a few hours and reaches its greatest intensity within twenty-four hours, as either a simple erythema or a more intense inflammation with the formation of papules. The reaction disappears, according to its intensity, in forty- eight hours or persists for weeks. Technic and Course of the Conjunctival Reaction.-'One or more drops of Koch's old tuberculin diluted with 5 parts normal salt solution is placed in the conjunctival sac. In from six to twenty-four hours the conjunctiva begins to redden and in milder reactions nothing more is noticed. How- ever, there may be all the symptoms of a severe conjunctivitis. The test is contra-indicated in individuals who have had disease of the ocular uveal tract, and the cutaneous test is generally preferable in children, as the con- junctival test sometimes sets up a phlyctenular conjunctivitis. Failure to react in persons manifestly tuberculous indicates that the system lacks the power to combat the poisons of tuberculosis with its pro- tective forces and, therefore, indicates an unfavorable prognosis. A large number of advanced progressive cases show no reaction to the tuberculin test. In order to be successfully nebulized a fluid must have sufficient vis- cidity. Glycerin nebulizes fairly well, but its nebulizing qualities are FORMULAS FOR USE WITH NEBULIZERS 558 DISEASES OF THE NOSE, THROAT, AND EAR greatly improved by the addition of a small proportion of tincture of ben- zoin. The benzoin should be added drop by drop with constant shaking of the bottle which contains the glycerin in order to evenly diffuse the benzoin through the glycerin, which becomes white and opaque from minute particles of benzoin suspended in the liquid. The mixture is com- paratively stable and the benzoin contained in about i dram of the tinc- ture can thus be suspended in 4 ounces of glycerin. Ordinary bleached petrolatum oil or albolene, with or without the pro- portion of benzoin it can be made to dissolve, nebulizes fairly well. Alcohol made viscid by the solution of one of the balsams, preferably benzoin, nebulizes fairly well. However, alcohol is somewhat irritating to the bronchial mucous membranes, and in use the product of a nebulizer containing an alcoholic solution is best diluted by the product of one con- taining a bland oily solution. The alcohol evaporates somewhat rapidly during the process of nebu- lization, so that the fluid in the nebulizer becomes more and more concen- trated, until, finally, the dissolved balsams are deposited within the nebulizer tubes and clog them up to an extent to prevent the instrument working unless more alcohol is added from time to time to replenish that which has evaporated. Any substance can be nebulized successfully if reduced to a fluid state by solution in one of the above three liquids. Essential oils and cam- phors are best dissolved in albolene for nebulization; substances insoluble in oil, either in the glycerin mixture or in alcohol. The following formulas may prove useful when used with a nebulizer. They should not be used with an atomizer, because the amount of fluid deposited on mucous membranes by an atomizer is many times greater than that derived from a nebulizer, and some of the following solutions are sufficiently concentrated to produce deleterious results if applied to the nose or pharynx by means of an atomizer. The fact that only a minute amount of nebulized fluid is deposited on the mucous membrane of the upper respiratory tract during the. short time available for the treatment of a patient during an ordinary office visit, probably accounts for the lack of enthusiasm manifested by most specialists for this method of treatment. The atomizer will probably always be the favorite instru- ment for applying remedies to the nose, pharynx, and larynx of office patients. 97. I). Fl. ext. ipecacuanha, f^ss; Glycerini, f 3 j; Tinctures benzoini, Tfixv.-M. Stimulating expectorant of considerable value in the early stages of bronchitis with scanty secretions and a sense of tightness across the chest; also in the early stages of coryza to increase secretions and render them more fluid. It relieves sensations of dryness in the nose and fauces from whatever cause. Asthmatic seizures are alleviated by nebulizing this formula with the addition of antispasmodics. Two fluidrams of the tincture of hyoscyamus, lobelia, and gelsemium, with 1 or 2 drops of chloro- form forms a suitable addition for this purpose. While being used alcohol will have to be added from time to time to prevent the fluid becoming too thick for nebulization. 98. Acidi tannici, oj; Glycerini, f5j--M. FORMULAS 559 Simple astringent useful in relaxed conditions of the mucous membrane of the upper respiratory tract. 99. I|. Camphorse, gr. x; Olei eucalypti, fpij; Petrolati albi liquidi (albolene), q. s. ad. fgj; Tincturse benzoini, TTlx.-M. Sedative and lubricant. Useful as a diluent of other sprays, especially those containing alcohol. 100. 3- cinnamomi, TTlxx; Olei eucalypti, Flxx; Menthol, gr. xl; Camphor, gr. Ixxx; Petrolati albi fluidi, fgviij.-M. (Porch.) Antiseptic, emollient. 101. 3- Mentholis, Camp horse, aa gr. x; Eucalyptalis, TQ.v; Liq. albolines, f 3 j; 01. rosae comp., TTlv.-M. Sig.-As an emollient to inflamed mucous membranes. (Byrne.) For acute and subacute coryza, catarrh in the head passages, dry catarrh, ozena, and rhinitis. May be used regularly by public speakers, singers, actors, etc. A pleasant stimulant and protective. 102. 1$. Chloretone, gm. 1; Camphoris, gm. 2.5; Mentholis, gm. 2.5; 01. cinnamomi, gm. 0.5; Petrolati albi liquidi (albolene), gm. 93.5.-M. (McClintock.) Anodyne, antiseptic, emollient. Useful in acute and subacute catarrh and bronchitis. 103. 3. Menthol, gr. xxx; Camphorse, gr. xxx; Cocainse muriatis, gr. xv; Tincturse benzoini, q. s. f§iv.-M. Use with nebulizer for acute bronchitis, pneumonia, and all acute inflammatory affections of the air-passages. Alcohol should be added occasionally, as the fluid becomes too thick from evaporation. 109. 3- dei caryophylli (cloves), Flxxx; Creosotse (beechwood), 5j; Olei picis liquidse, 5j; lodini, _ gr. xxx; Tincturse benzoinse, q. s f§iv.-M. 560 DISEASES OF THE NOSE, THROAT, AND EAR Use with nebulizer for pulmonary and laryngeal tuberculosis, and in any condition requiring an active antiseptic. Alcohol should be added occasionally, as the fluid becomes too thick from evaporation. 105. 3. Olei cassiae, Blxxx; Camphor-menthol, 3 ij; Cocainae, gr. viij; Tincturae benzoini, q. s. f§iv.-M. Use with nebulizer for acute colds, sore throat, and in all cases of acute inflammation or congestion of the upper air-passages and middle ear. io6. I|. Ichthyol, Sijj Adeps lanse, Petrolati, aa 3j.-M. 107. I|. Unguenti hydrargyri, Unguenti iodini, Unguenti belladonna, aa 3j--M. Both of the above ointments are effective applications in commencing mastoiditis and adenitis, etc. They should be smeared thickly over the parts and covered with waxed paper and a bandage. However, in spite of these precautions the ointments are liable to stain clothing, bed linen, etc. Therefore, an iodine ointment (Menley & James) which does not have these disadvantages is sometimes preferable. 109. I}. Hydrargyri oxidi flavi, gr. vj; Olei petrolati, q. s.; Petrolati, 3j.-M. Useful as an application in eczema of the auricle after all scabs and crusts have been removed by means of hydrogen peroxid. This ointment should be well rubbed into the inflamed tissues, and a few applications is some- times sufficient to bring about a cure if care be exercised that purulent dis- charges from the tympanum are not allowed to come into contact with the skin of the auricle. In eczema of the canal the following is sometimes more effective: 109. I). Acidi salicylici, gr. xxx; Zinci oxidi, Pulver is amyli, Sa $vi; Petrol, molis, gii.-M. no. 1$. Cocainae hydrochloridi, gr. xij; Adeps lanae, 3ij--M. Useful in relieving the pain of subacute catarrh of the middle ear, furunculosis, etc. An ointment penetrates the skin of the canal more readily than a watery solution. For the relief of the pain of aural neu- ralgia or acute catarrh the ointment is simply placed as deeply within the canal as possible. For the relief of the pain of furunculosis the ointment is smeared upon a cone of cotton, which is wedged into the meatus with as much pressure as the patient conveniently can bear. The pressure, at first painful, ultimately relieves congestion and discomfort. OINTMENTS FORMULAS 561 nr. 3. Phenol, Camphorae, Cocain hydroch, aa 5 ss.-M. When these three solids are mixed a liquid results. One drop placed in contact with the drum-head is more quickly effective in easing the pain of acute otitis than cocain ointment. PIGMENTS 112. I|. lodini, gr. v-xv; Potassii iodidi, gr. xv-xlv; Glycerini, fgij.-M. 113. I|. Boroglycerid, 50 per cent. 114. 1$. Acidi tannici, gr. xl; Glycerini, f 5 j.-M. Formula 114 is an excellent application to the nasopharynx in the post- nasal catarrh of adults. In children Formula 112 generally yields better results. Formulas 112-114 may be used in the treatment of chronic hypertrophic rhinitis. The effects of the application vary with the amount of the solu- tion used. No more of the iodin solution should be applied at one time than will produce a momentary sensation of discomfot. Applied inside the crypts of the tonsils by means of a cotton-tipped probe bent at a right angle it often brings about a rapid absorption of the hypertrophied glands. However, Battey's solution (see Caustics) usually yields better results. DUSTING -POWDERS There is a well-founded prejudice against the use of dusting-powders in the larynx; same authors stating that they never should be used, because when thrown from the powder-blower they strike a blow upon the inflamed mucous membrane and remain as a foreign body until dissolved or expec- torated. However, as a matter of fact, the application of a powder to the laryngeal mucous membrane when gently and skilfully done is generally less disagreeable to the patient than the application of a fluid by means of a swab, and because of the prolonged action of the powder, as it slowly dissolves, sometimes produces better results. It should be borne in mind that a large amount of any powder thrown violently into the larynx fre- quently produces alarming spasm of the glottis. 115. I). Menthol, gr. j; Sodii bicarbonatis, gr. ij; Magnesii carb, (levis), gr. iij; Cocainae hydrochloridi, gr. iv; Sacchari lactis, 3iss--M. Sig.-Use as snuff every two or three hours. The most marked relief follows the use of this powder, and a few appli- cations will do much to abort acute rhinitis. Its effects are immediate, highly agreeable to the patient, and continue for a number of hours. The preparation should be dispensed in a tightly corked vial to prevent evapo- 562 DISEASES OF THE NOSE, THROAT, AND EAR ration of the menthol, and a pinch should be sniffed up into each nostril every two or three hours or sufficiently often to maintain the nose in a patulous condition and limit the secretions. As the result of the use of the snuff the patient remains practically free from all nasal symptoms during the attack, and there is no danger of contracting the cocain-habit where the laws, as in Pennsylvania, forbid the refilling of a prescription containing cocain without the consent of the physician. 116. 1$. Argenti nitratis, gr. xxx; Zinci stearatis, 3j-M. The above is useful in the treatment of atrophic rhinitis. It should be applied either as a snuff or with the powder-blower to the nasal mucous membrane; its use is followed by a moderate amount of smarting and increased nasal discharge. 117. I|. Zinci sulphatis 3j-iv; Sacchari lactis, §j; Acaciae, gr. x.-M. 118. I|. Alumnol, 3j; Sacchari lactis 3ij.-M. Useful as applications to the laryngeal mucous membrane in acute and chronic laryngitis. In cases in which bronchitis as well as laryngitis is present the powder should be applied during deep inspiration, in order that it may reach the trachea and bronchi. 119. 1$. lodoformis, ' gr. xxx; Acidi tannici, gr. xx; Bismuthi subnitratis, 3j.-M. Useful as an application in syphilitic and tubercular laryngitis 120. I). Bismuth, subnitratis, 5ij; Acacias, gr. x; lodoformis, 5 ss; Morphiae sulphatis, gr. xx; Acidi tannici. gr. xxx.-M. Useful as an application to the laryngeal mucous membrane in tuber- cular and syphilitic laryngitis, in the earlier stages of acute laryngitis, or in any laryngeal affection characterized by irritability and pain. 121. Orthoform. This nearly insoluble substance has the property of producing analgesia when applied to exposed nerve-endings. It is, therefore, especially valu- able as an application to irritable ulcers after they have been cleansed with Dobell's solution or hydrogen peroxid. Its anesthetic effects are increased by a previous application of a solution of cocain and persist for four or five hours. When insufflated into a tubercular larynx the powder produces a momentary smarting, followed by analgesia more or less complete, which persists as long as the powder adheres, to an abraded surface or an ulcer. The powder possesses decided antiseptic qualities and promotes the healing of tubercular ulcerations. It has little effect FORMULAS 563 upon the unbroken mucous membrane and its prolonged application to the skin in the neighborhood of ulcerations sometimes causes eczema. A nurse or one of the patient's friends can be taught to insufflate ortho- form into a tubercular larynx ten minutes before each meal, and in many instances thus secure complete relief from dysphagia. Orthoform is said to be non-toxic, and hence may be used locally in liberal quantities. In a certain proportion of cases anesthesin gives better results than otho- form in securing relief from pain. When ulcers exist, healing is best secured by insufflations of omorol: an'insoluble albuminate of silver. 122. 3. Pulvis acidi borici. It is absolutely necessary that the powdered boric acid, insufflated within the tympanum as an application in the treatment of purulent inflammation, should be impalpable and free from all grit, as the sharp- pointed crystals of this substance are extremely irritating. A good plan is to test the powdered boric acid by rubbing a small quantity upon the lip with the tip of a finger, rejecting as unfit for use inside the ear those specimens that are "gritty." It is important also that too large a quantity of boric acid should not be thrown into the ear at one time or it may form a hard mass and thus pre- vent the escape of discharges. 123. I). Acetanilid, 3 j; Acidi borici, gj.-M. Sig.-Use as a dusting-powder to infected or foul-smelling wounds after mastoid operations. Acetanilid, a derivative of anilin, is a white powder but slightly soluble in water and possessing decided antiseptic properties. It is, either alone or diluted with boric acid powder, a somewhat popular hospital dressing for superficial wounds "that are not doing well." It is especially useful in wounds after a mastoid operation where the discharges are foul smelling and the chiseled bone remains long uncovered by granulations. The powder, under such circumstances, should be thickly dusted into the wound. lodin is liberated when the substance is brought into contact with organic matter and acts as an antiseptic. 124. Xeroform. Bismuth oxid, 49 per cent.; Tribromphenol, 50 per cent.-M. Xeroform or bismuth tribromphenol is an oderless synthetic product of the manufacturing chemists, and presumably has the sedative and as- tringent properties of bismuth combined with the marked antiseptic qualities of bromin and carbolic acid. As it has been given internally (5 to 7 gm. daily) by Hueppe, during the cholera epidemic at Hamburg, in 1893, with excellent results, it may be assumed that its local application to wounds and mucous membranes is absolutely devoid of danger of toxic effects. . Upon wounded or inflamed mucous membranes it is an astringent, analgesic, and an antiseptic. 125. Novargan. 564 DISEASES OF THE NOSE, THROAT, AND EAR May be used as an application to the nasal and tympanic mucous mem- brane in 2 to 15 per cent, solutions. It is proteinate of silver and soluble in water up to 50 per cent. 126. T$. Aspirin (acetyl-salicylic acid). Sig.-Apply with a powder-blower to the tonsils three times a day after gargling with an alkaline solution. Dr. C. F. Kieffer, after investigation of the records of the army hospital at Fort Russell, Wyo., during ten years, states that 21.3 per cent, of the cases of acute articular rheumatism had a previous attack of tonsillitis, the time between the attacks averaging twenty-four days. He, therefore, treated a number of cases of acute tonsillitis by alkaline gargles and liberal applications of aspirin three times a day with the result of great local comfort and an average duration of the disease of three days. However, the duration of the disease was not lessened by the internal administra- tion of aspirin or salicylates. PROTECTIVES A useful formula as a protective to the nasal mucous membrane and for injection through a catheter into the middle ear is the following: 127. 1$. Menthol, gr. v; Camphor, gr. xx; Petrolati albi liquidi, fgij.-M. Sig.-Use with an antomizer. To the above 1 or 2 drops of oil of eucalyptus, oil of pine-needles, or oil of cinnamon may be added. SEDATIVES 128. Strontii bromidi, 5j; Sodii bromidi, Potassii bromidi, aa 5ij; Essentia pepsini, fgiv.-M. Sig.-i or 2 teaspoonfuls in a tumbler one-half full of water after meals and at bedtime. Useful in the useless cough of hysteric individuals. 129. 3. Acidi hydrobromici diluti, f §ij. Sig.-15 to 30 drops in a tumbler of water one hour after meals. Hydrobromic acid also yields in the majority of cases somewhat better results in the treatment of tinnitus than bromid of sodium or the mixed bromids. 130. 1$. Sumbul, gr. ij; Camphor, gr. j; Valeriani, gr. j; Ext. hyoscyam., gr. ss.-M. Pil. No. i. Ft. pit No. xxx. Sig.-One every two hours. Useful in cases where bromids are not advisable. FORMULAS 565 LOCAL SEDATIVES i31. Antipyrin, A solution of antipyrin of 2 to 4 per cent, strength, when sprayed upon the mucous membrane of the nose or pharynx, has the power of con- tracting the capillaries and of producing an artificial anemia, which effect is maintained for from three to five hours. Solutions of antipyrin may be used with the atomizer in all acute inflammations of the mucous membrane of the upper respiratory tract. When used after the application of cocain to the interior of the nose a 4 per cent, solution will maintain the contractile effect of cocain upon the erectile tissue for several hours. When sprayed upon the nasal mucous membrane without the previous application of cocain a 4 per cent, solution gives rise to a smarting sensation, which, how- ever, quickly subsides. Antipyrin solutions of the proper concentration applied to mucous membranes produce analgesia, but not local anesthesia. From 25 to 50 per cent, solution is extremely useful as a daily application to the larynx in all forms of laryngeal inflammation. A brush or a dossil of absorbent cotton wrapped about a bent probe should be saturated with the solution and applied to the glottis. The application of antipyrin solutions of the strength of 50 per cent, and upward produces a burning sensation, quickly followed by a sensation of relief and comfort. Applied in this manner to the larynx antipyrin is not an anesthetic, but an analgesic, whose effects persist for several hours. In the strength of 5 to 10 per cent, solutions antipyrin is superior as an antiseptic to Van Swieten's liquid. In thera- peutic doses antipyrin acts as an antispasmodic, diminishing the reflex excitomotor power of the spinal cord, and also as an analgesic, relieving the pain of neuralgia and migraine, whether due to reflex nasal irritation or to some other cause. Applications of strong solutions of antipyrin to the larynx should be supplemented by the patient inhaling five or six times a day the spray from an atomizer containing a 4 per cent, solution. The effects of antipyrin upon the heart should, of course, be borne in mind and the patient, if weak, should be cautioned not to swallow any portion of the spray deposited in the mouth, and not to use too large a quantity of the solution at one time, although in a 4 per cent, solution there is in 1 ounce only about 20 gr. of antipyrin, and much more than this amount in twenty-four hours probably could be used with impunity by most patients. 132. I|. lodoformi, gr. lx; Ether, gij.-M. Sig.-Use as a spray for the larynx. 133. 3. Resorcinol, gr. v; Adrenalin chlor., gr. ss; Acidi borici, gr. xv; Aquae camphorae (ferv.), §ss; Glycerini, $ss; Aquae dest. q. s. ad. gij.-M. Sig.-Use as a spray in nose four or five times daily as a local sedative. (Ingals.) 566 DISEASES OF THE NOSE, THROAT, AND EAR 134. 1$. Menthol, gr. j; Olei gaultheriae, Tfliij; Camphorae, gr. xv; Eucalyptol, TH.v; Adrenalin (1:1000), TH.xxiv; Petrolati albi, Adipis lanae, aa § ss.-M. Sig.-Apply to the inside of the nose every two hours as a sedative in acute rhinitis. (Byrne.) TONICS 135. 3- Hydrarg. bichlor., gr. Acidi arseniesi, gr. J; Ferri pyrophos., gr. vj; ■ Quinise sulph., gr. xv.-M. Ft. pil. No. xxiv. Sig.-One after meals. (Seiler.) Useful as a tonic pill in catarrh of the nose and throat, with a debilitated condition of the system. 136. I|' Ext. bellad. fol. ale., gr. iv; Quin, sulph., gr. xxij; Ferri sulph, exsic., gr. vij; Strych. sulph., gr. Acidi arsenosi, gr. Oleoresinae piperis, TTlviiss.-M. Ft. pil. No. xv. Sig.-A pill three times a day. In the treatment of the neuralgia of the ear, which is often a sign of defective nutrition and associated with anemia, the above combination is sometimes useful. 137. Elixir ferri quininae et strychninae phosphatum. 4 cc., or 1 fl. dr., representing about 0.06 gm. (1 gr.) ferric phosphate, 0.03 gm. (j gr.) quinin, and 0.001 gm. (^ gr.) strychnin. Hematinic and nervine. 138. Elixir glycerophosphatum, N. F. 4 cc., or 1 fl. dr., representing 0.06 gm. (1 gr.) absolute sodiumglycero- phosphate and 0.03 gm. (J gr.) calcium glycerophosphate. Nerve tonic, reconstructive. 139. 3. Hydrarg. chlor, corrosiv., gr. Arsen, triox., gr. J; Acidi hydrochloridi dil., fgiss; Tincturse ferri chlor., f 3iv; Elixir, calisaya, q. s. ad. f^iij.-M. Sig.-Teaspoonful in water after meals. INDEX Abductor paralysis of larynx, 293 spasmodic, 293 Abscess, extradural, from otic disease, 496 in mastoid, perforation of, 472 of cerebellum from otic disease, 497 of cerebrum from otic disease, 497 of membrana tympani, 384 of nasal septum, 144 peritonsillar, 211 treatment of, 212 retropharyngeal, 241 treatment of, 242 subdural, from otic disease, 496 Accessory sinuses of nose, dis- eases, 150 differentiation, 155 inflation, by Valsalva's method, 163 operations on, accidents and dangers of, 191 Acetanilid, 563 Acetyl-salicylic acid, 564 Acid, acetyl-salicylic, 564 boric, 534 powdered, 563 carbolic, 542 chromic, 542 in otitis media suppurativa acuta, 421 in treatment of anterior nasal hypertrophies, 81 hydrobromic, 564 in hay-fever, 108 nitric, in aphonia, 549 nitromuriatic, in hay-fever, 108, 549 trichloracetic, 542 in treatment of anterior nasal hypertrophies, 81 Acoustics, 330 Actinomycosis of pharynx, 240 of pharynx, treatment, 241 Adam's apple, 250 Adams' septum forceps, 146 Adductor muscles, spasm of, 288 paralysis of larynx, 291 Adenoid curettes, 202 forceps, Juracz's, 201 Adenoids complicating otitis media catarrhalis sub- acuta, 400 of pharyngeal tonsil, 199 Aditus ad antrum, 320 Adrenalin, 545 effect of, on heart, 546 in hay-fever, no, 546 in nasal hemorrhage, 117 secondary hemorrhage after, .546 Aerial vibrations, 330 Agger nasi, 59 Air-bag, Politzer's, 343 in otitis media catarrhalis acuta, 398 Air-compressors for atomizers, 45 Air-pump, water, 45 Alse of nose, 56 Albolene as nebulizer, 558 Albuminuria in diphtheria, 301 Alcohol, 539 as nebulizer, 558 Alexander's mastoid gouges, 469 Allen's nasal applicator, 40 with Gottstein's cotton Plug, 93 probe, 41 as applicator in Eustachian tube, 349 for removing cerumen, 374 speculum, 32 Alligator forceps, 179 Alteratives, 540 Alypin as local anesthetic, 537 Ammonium salts, lozenges, 553 567 568 INDEX Anemia of labyrinth, 516 of larynx, 260 Anesthesia, local, for removal of aural polypi, 537 of ear, 537 of tonsils, 537 of larynx, 286, 536 of nasal mucous membrane, 106 of pharynx, 243 Anesthetic in tracheotomy, 308 Anesthetics, local, 536 Aneurysm of aorta, laryngeal paralysis from, 258 Angina, Ludwig's, 233 treatment of, 233 Vincent's, 234 treatment of, 235 Angioma of larynx, 280 of nose, 121 Angle, hypertrophied, of nasal septum, 126 Annulus tympanicus, 320, 455 Anosmia, 106, 158 Antipyrin, 565 Antitoxin for hay-fever, 111 Antrum, mastoid, 325 of Highmore, illumination, 161 inflammation, 158 Caldwell-Luc, operation, 167 Cowper's treatment, 164 Denker's operation, 169 diagnosis, 160 etiology, 158 Janson's operation, 167 pathology, 159 prognosis, 163 radical operations, 166 symptoms, 160 treatment, 163 soft spot, 161 Anvil bone of ear, 321, 322 Aorta, aneurysm of, laryngeal paralysis from, 258 Aphonia, nitric acid in, 549 Aponeurosis, pharyngeal, 193 Argyrol, 539 Arteries of auricle of ear, 315 of Eustachian tube, 325 of larynx, 257 of nasal fossae, 61 of nose, 58 of pharynx, 194 Arteries of tympanum, 323 Aryepiglottic fold, 27 Arytenoid cartilages, 27, 252 Arytenoideus muscle, 254 Arytenoids, pyriform, 275 Aspirin, 564 Asthma, climate for, 544 hay-, 107 miller's, 107 Astringents, 538 Atomizer, 41 air-compressors for, 45 DeVilbiss, 42 for home use, 41, 44 sterilization of, 52 Atrium of tympanum, 318 Atrophic pharyngitis, 229 treatment, 229 rhinitis, 91. See also Rhinitis, atrophic. Attic of tympanum, 318 Auditory canal, external, 315. See also External audi- tory canal. nerve, 329 Aural auscultation-tube, 341 cholesteatoma, 433 polypi, 428 removal of, anesthesia for, 537 stethoscope, 341 Auricle of ear, 314 arteries of, 315 burns of, 356 cleft lobule, 354 congenital defects, 350 cutaneous diseases, 354 cyst of, 356 dermatitis of, 355 eczema of, 361 erysipelas of, 359 phlegmonous, 360 frost-bite of, 355 gangrene of, 360 hematoma of, 352 herpes of, 357 hyperemia of, 355 impetigo contagiosa of, 357 keloid of, 354 lupus vulgaris of, 357 muscles of, 315 nerves of, 315 new growths on, 362 othematoma of, 352 INDEX 569 Auricle of ear, perichondritis of, 352 chronic, 353 skin diseases, 354 syphilis of, 358 veins of, 315 vessels of, 315 wounds of, 353 Auscultation of ear, 346 Auscultation-tube, aural, 341 Toynbee's, 342 Autolaryngoscopy, 25 Autophony, 406 Autumnal catarrh, 107 Axial ligament of malleus, 321 Babinski's sign in intracranial complications of dis- eases of ear, 491 Bacteria in blood, 493 Bacteriemia, 493 Ballance's method of skin-graft- ing, 483 Ballenger's double elevator, 139 ethmoid knife, 183 modification of Gleason's opera- tion for deviated sep- tum, 136 operation for ethmoiditis, 183 septum knife, 138 swivel knife, 141 Basophiles, 494 Battey's solution, 542 Beckmann's scissors, 85 Bellocq's cannula in nasal hemor- rhage, 120 Bell's palsy from otic disease, 509 Benzoin, compound tincture of, 48, 540 Bernay's sponge, 115 Bichlorid of mercury, 534 Bifid uvula, 247 Bing's test for hearing, 337 Biniodid of mercury, 535 Bismuth tribromphenol, 563 Blake's cannula, 44 polypus snare, 421 Blood, bacteria in, 493 coagulation time of, 493 discharge of, from labyrinth, significance, 517 examination of, in intracranial complications of mas- toiditis, 492 Blood-plaques, 493 Blood-supply of tonsils, 197 Boekel's automatic cut-off, 46 Bone drills, 89 electric-motor, 90 for exostoses of septum, 89 Boric acid, 534 powder, 563 Bosworth's operation for devi- ated septum, 130 saw, 88 tongue-depressor, 25 Bottle-inhaler, 48 Boucheron's specula, 37 Bougies, Eustachian, 349 Breathing, mouth-, 77 Bridge of nose, flattening, 146 Bright's disease, otitis media from, 441 Bronchitis in diphtheria, 301 Bronchopneumonia in diphtheria, 301 Bronchoscopy, direct, 29 Brown and Price's modification of Gleason's operation for deviated septum, 136 Bucklin's saw, 88 Buried tonsil, 214 Burns of auricle, 356 Bursitis, chronic, 206 Cabinet, Pynchon's, 47 Calcium chlorid, 547 Caldwell-Luc operation for in- flammation of antrum of Highmore, 167 Callus, provisional, of nasal sep- tum, 126 Caloric tests for nystagmus, 523 Camphomenthol lozenges, 552 Canalis reuniens, 325, 328 Cannula, Bellocq's, in nasal hemorrhage, 120 Blake's, 44 Hartmann's frontal sinus, 174 Carbolic acid, 542 Carcinoma of larynx, 282- treatment, 284 of nose, 121, 125 treatment, 125 Caries in mastoiditis, 459, 460 of temporal bone, 430 Carter's nasal splint, 146 570 INDEX Cartilage, columnar, dislocation of, 143 cricoid, 251 sesamoid, 56 supravomerine, 57 thyroid, 250 triangular, of nose, 57 vomerine, 57 Cartilages, arytenoid, 27, 252 of larynx, 250 of Santorini, 2 53 of Wrisberg, 27, 253 pitcher-shaped, 252 Santorini's, 27 Catarrh, acute, 65 autumnal, 107 chronic, 65 of larynx, climate for, 544 of nose, climate for, 544 of pharynx, climate for, 544 of frontal sinus, 170 of middle ear, 392. See Otitis media. postnasal, 199 Catching cold,. 63 Catheter, Eustachian, 343 Hartmann's, 344 inflation of middle ear through, 347 introduction of, into Eusta- chian tube, 344 medication through, 348 spraying through, 347 test of patency of Eustachian tubes, 343 Catheterization of Eustachian tubes, 343 introduction of catheter, 344 obstacles to, 345 Caustic, hydrogen peroxid as, 535 Caustics, 542 Cautery knives, 82 Cells, ethmoid, diseases of, 181 hyperplasia of, 181 inflammation of, 181 Ballenger's operation, 183 Hajek's operation, 184 suppuration of, 181 hearing, 328 sphenoidal, empyema of, 186 Hajek's operation, 188 Skillern's modifica- tion, 189 Cells, sphenoidal, empyema of, treatment, 187 Cerebellar nystagmus, 521 Cerebellum, abscess of, from otic disease, 497 Cerebrospinal rhinorrhea, 113 Cerebrum, abscess of, from otic disease, 497 Cerumen, impacted, 375 removal of, 376 Chalk deposits on membrana tympani, 386 Chemic rhinitis, 63 Chink of glottis, 27, 256 Chisel, Killian's frontal sinus, 168 Chloroform, 554 Choanae, 30 Cholesteatoma, aural, 433 Chorda tympani nerve, 323 Chorea, laryngeal, 287 Chromic acid, 542 in otitis media suppurativa acuta, 421 in treatment of anterior nasal hypertrophies, 81 Chromium sulphate, 557 Cleft lobule of auricle, 354 Clergyman's sore throat, 227 Climate for asthma, 544 for chronic fibroid phthisis, 544 for hay-fever, 544 for pulmonary tuberculosis, 544 for tubercular laryngitis, 544 Climatology, 543 Coagulation time of blood, 493 Coagulose in hemophilia, 120 Cocain, 536 in hay-fever, 109, no in lanolin, 536 lozenges, 553 poisoning, 538 Cochlea, function of, 329 Cold, catching, 63 cow, 107 horse, 107 x in head, 64, 68 peach, 107 rose, 107 snow, 107 Collodion, contractile, 554 Columnar cartilage, dislocation, 143 Comedones, 58 Concussion of labyrinth, 517 INDEX 571 Conjunctival reaction in tuber- culosis, 557 Contractile collodion, 554 Corti's organ, 328 rods, 328 Coryza, 64 vasomotoria periodica, 107 Cotton applicator, 40 Cough, laryngeal, spasmodic, 287 mixtures, 542 useless, 228 Cow cold, 107 Cowper's treatment of inflamma- tion of antrum of High- more, 164 Crest, vomerine, 58 Crico-arytenoideus lateralis mus- cle, 254 posticus muscle, 255 Cricoid cartilage, 251 Cricothyroid muscle, 254 Crisis, laryngeal, 293 Croup, false, 288 kettle, 550 formulas for use with, 550 Croupous inflammation of Schneiderian mem- brane, 65 tonsillitis, 206 Crypts of tonsils, 196 Curet, adenoid, 202 Fetterolf's, 202 Gleason's, 468 Gottstein's, 202 Whiting's, 466 Curvature of membrana tym- pani, changes in, 379 Cutaneous diseases of auricle, 354 reactions in tuberculosis, 557 Cyst of auricle, 356 of larynx, 280 of nose, 121, 123 of tonsil, 214 Cystocele of frontal sinus, 181 Davidson's powder-blower, 49 Deafness from otitis media sup- purativa chronica, oper- ation for, 446 hysteric, 517 in otitis media catarrhalis chronica, 405 middle-ear and internal-ear, differentiation, 515 Debility, otitis media from, 442 Delstanche's masseur, 40 Denker's operation for inflamma- tion of antrum of High- more, 169 Dermatitis of auricle, 355 Destruction disharmony, 526 Detergents, aqueous, 533 De Vilbiss atomizer, 42 Diabetes, otitis media from, 441 Dilator, Jansen's, 468 Dionin, 541 Diphtheria, 296 albuminuria in, 301 bronchitis in, 301 bronchopneumonia in, 301 classification, 297 complications, 300 diagnosis, 301 endocarditis in, 301 epistaxis in, 300 etiology, 296 extubation in, 307 faucial, 297 intubation in, 304 accidents following, 306 feeding in, 308 inability to breathe after, 3°7 treatment of patient, 307 laryngeal, 297, 299 malignant, 297 mild, 297 nasal, 297, 299 otitis media from, 438 otorrhea in, 301 paralysis in, 299' pathology, 296 pericarditis in, 301 pleurisy in, 301 prophylaxis, 302 serum treatment, 303 severe, 297 symptoms, 297 systemic infection, 300 toxemia in, 300 tracheotomy in, 308. See also Tracheotomy. treatment, 301, 302 local, 302 operative, 304 prophylactic, 302 serum, 303 well-marked, 297 INDEX 572 Diphtheritic inflammation of Schneiderian membrane, 66 paralysis, 299 Diploetic mastoid, 457 Disharmony, destruction, 526 stimulated, 526 Dislocation of columnar cartilage, _ 143 of nasal septum, 145 Dobell's solution, 533 Dog nose, 99 Drill, bone, 89 electric-motor, 90 for exostoses of septum, 89 Gleason's, 90 Drum-head, 316. See also Mem- brana tympani. Ductus cochlearis, 325, 327, 328 Dusting-powders, 561 Dysacousma, 406 Dysesthesia acoustica, 406 Ear, 314 anatomy of, 314 anesthesia of, 537 auscultation of, 346 anvil bone of, 321, 322 auricle of, 314. See also A uricle of ear. cholesteatoma of, 433 diseases of, intracranial com- plications, 490 pathologic conditions of nose causing, 339 of pharynx causing, 339 examination of, 54 external, 314. See also Exter- nal ear. forceps, Politzer's, 385 hammer bone of, 321 internal, 314, 325. See also Labyrinth. lobule of, 315 middle, 314, 316. See also Middle ear. polypi in, 428 removal of, anesthesia for, 537 specula, 36 stirrup bone of, 321, 322 syringe, soft-rubber, 43 Ear-spout, metal, 378 Ecchondroma of nose, 121 Ecchondroses of septum, 85 treatment, 86-90 Eczema of auricle, 361 Edema, infraglottic, 270 of glottis, 270 of larynx, acute, 270 Electric tests for nystagmus, 524 Electrolysis in stricture of Eusta- chian tube, 350, 414 Elevator, Ballenger's double, 139 Freer's, 140 Elongation of uvula, 248 Empyema of labyrinth, 525 of sphenoidal cells, 186 Hajek's operation, 188 Skillern's modifica- tion, 189 treatment, 187 Encephalitis, diffuse, 498 localized, 498 Encephaloscope, Whiting's, 500 Endelmann-Galton whistle, 332 Endocarditis in diphtheria, 301 Endolabyrinthitis, 525 Endolymph, 326 Entotic use of speaking-trumpet in testing hearing, 338 Eosinophiles, 494 Epiglottis, 250, 253 muscles of, 256 turban-shaped, 275 Epilepsy, laryngeal, 290 Epinine, 545 Epistaxis, 113. See also Nasal hemorrhage. Epithelial plug in auditory canal, 378 Equinia of pharynx, 239 Erectile tissue of nose, 60 Ermold's tonsillotome, 216 Erysipelas of auricle, 359 phlegmonous, 360 of pharynx, 231 treatment, 232 Ethmoid cells, 152 diseases of, 181 hyperplasia of, 181 inflammation of, 181 Ballenger's operation, 183 Hajek's operation, 184 suppuration of, 181 hook, Hajek's, 184 knife, Ballenger's, 183 Ethmoiditis, 181 INDEX 573 Eucain as local anesthetic, 537 Eustachian bougies, 349 catheter, 343 Hartmann's, 344 inflation of middle ear through, 347 introduction of, into Eusta- chian tube, 344 medication through, 348 spraying through, 347 tube, 324 Allen's probe as applicator in, 349 arteries of, 325 catheterization of, 343 introduction of catheter, 344 obstacles to, 345 examination, 55 introduction of catheter into, 344 muscles of, 324 nerves of, 325 patency of, 341 catheter test, 343 in chronic otitis media, 410 Politzer's test, 341 Valsalva's test, 341 pharyngeal mouths of, 341 stricture of, 413 diagnosis, 413 electrolysis in, 350, 414 inflation in, 414 massage in, 414 phonomassage in, 415 pneumomassage in, 415 tinnitus in, 416 treatment, 414 Ewald's law, 520 Examination of patients, 53 Exostoses of external auditory meatus, 370 of nose, 121 of septum, 85 treatment, 86-90 External auditory canal, 315 circumscribed inflamma- tion of acute, 362 diseases of, 362 epithelial plug in, 378 exostosis of, 370 foreign bodies in, 371 removal, 373 furunculosis of, 362 External auditory canal, hyperos- tosis of, 370 inflammation of, 362. See also Otitis. insects in, 371 mycosis of, 368 osteoma of, 370 washing out of, 377 ear, 314 congenital defects, 350 diseases, 350 fistula about, 350 of newborn, 452 Extradural abscess from otic disease, 496 Extubation in diphtheria, 307 Eye syringe, soft-rubber, 43 Face, frog, 123 Facial nerve in newborn, 455 wounding of, in mastoid operation, 479 paralysis from otic disease, 509 diagnosis, 513 prognosis, 514 symptoms, 511 treatment, 514 False croup, 288 vocal cords, 256 Falsetto voice, 259 Farcy of pharynx, 239 Fatigue, excessive, otitis media from, 442 Faucial diphtheria, 297 tonsils, 195 Fenestra ovalis, 320 rotunda, 320 Fetterolf's curet, 202 files, 137 Fibroma, nasopharyngeal, 123 of larynx, 280 of nose, 121, 123 Files, Fetterolf's, 137 Finger test for nystagmus, 523 Fissure, Glaserian, 320 Fistula about external ear, 350 test for nystagmus, 525 Flattening of bridge of nose, 146 Follicular pharyngitis, 226 chronic, 227 tonsillitis, acute, 206 treatment of, 209 chronic, 210 treatment of, 210 574 INDEX Foramen of Rivini, 379, 389 Forceps, Adams' septum, 146 alligator, 179 Hartmann's, 466 foreign body and polyp, 385 Juracz's adenoid, 201 Politzer's ear, 385 Struycken's, 84 Foreign bodies in external audi- tory canal, 371 removal, 373 in larynx, 284 treatment, 285 in nose, 104 in pharynx, 245 treatment, 246 Formulas, 533 alteratives, 540 anesthetics, local, 536 aqueous detergents, 533 astringents, 538 caustics, 542 cough mixtures, 542 dusting-powders, 561 for croup kettle, 550 for hay-fever, 548 for inhaler, 550 for nebulizers, 557 gargles, 545 hemostatics, 545 hypnotics, 547 local sedatives, 565 lozenges, 550 miscellaneous, 554 ointments, 560 pigments, 561 protectives, 564 sedatives, 564 sprays, 533 tonics, 566 washes, 533 Fossa mastoid, 474 supratonsillaris, 195 Fossae of nose, arteries, 61 nerves, 61 Foster's speculum, 140 Fox's head-band, 18 Frambesia, 99 Freer's elevators, 140 septum knife, 138 Frog face, 123 Frontal sinus, catarrh of, 170 cystocele of, 181 diseases, 169 Frontal sinus, inflammation of, 169 treatment, 171 mucocele of, 181 purulent disease of, chronic, J 74 Killian's operation for, 177 Frontonasal canal, 171 Frost-bite of auricle, 355 Furunculosis of external auditory canal, 362 Galton-Edelmann whistle, 332 Galvanocautery for removal of anterior nasal hyper- trophies, 78 handle, 81 in chronic follicular pharyn- gitis, 229 Galvanopuncture for hypertro- phied tonsils, 215 Gangrene of auricle, 360 Gangrenous inflammation of neck, 233 Gargles, 545 Gelle's test for hearing, 337 Genital spots, nasal, 107 Glanders of pharynx, 239 Glaserian fissure, 320 Glass instruments, sterilization, 5i Gleason's antrum rasp, 166 curette, 468 electric-motor drill, 90 head-band, 19 nasal tubes, 135 operation for deviated septum, 130 Ballenger's modifica- tion, 136 modifications, 136 Price and Brown'S modi- fication, 136 speculum, 32 Globus hysterias, 244 Glosso-epiglottic fold, 27 fossae, 27 Glottis, 27, 256 chink of, 27, 256 edema of, 270 Glycerin as nebulizer, 557 Goiter, lingual, 225 Gottstein's curet, 202 INDEX 575 Gottstein's curet, treatment of atrophic rhinitis, 93 Gouges, Alexander's, 469 Goundou, 99 Granular spots on membrana tympani, 384 Gruber's method of catheteriza- tion of Eustachian tubes, 345 Guaiacum lozenges, 551 Habitus lymphaticus, 203, 222 Hajek's ethmoid hook, 184 operation for empyema of sphenoidal cells, 188 Skillern's modifica- tion, 189 operation for ethmoiditis, 184 Hall's saws, 88 Hammer bone of ear, 321 Hard tonsil, 214 Hard-rubber nozzles, steriliza- tion, 51 Harmony, 333 Hartmann's Eustachian catheter, 344 forceps, 466 foreign body and polyp forceps, 385 frontal sinus cannula, 174 Haseltine's operation for septal perforations, 145 Hassler's site of predilection, 433 Hay-asthma, 107 Hay-fever, 107 adrenalin in, no, 546 antitoxin for, in climate for, 544 cocain in, 109, no etiology, 107 hydrobromic acid in, 108 hypersensitiveness, 109 mineral acids in, 108, 549 nitromuriatic acid in, 108, 549 pollantin in, in prognosis, in remedies for, 548 symptoms, 108 treatment, 108 Head, cold in, 64 noises in otitis media catar- rhalis chronica, 407 Head-band, Fox's, 18 Gleason's, 19 Hearing cells, 328 in mastoiditis, 463 in otitis media catarrhalis chronica, 405 tests for, 54, 330, 332 Bing's, 337 entoticuse of trumpetfor, 338 Gelle's, 337 pressions centripetes, 337 Rinne's, 335 Schwabach's, 337 voice, 339 watch, 338 Weber's, 334 Heart, effect of adrenalin on, 546 Heath's radical mastoid opera- tion, 486 Hematoma of auricle, 352 of nasal septum, 143 treatment, 144 Hemoconias, 493 Hemophilia, 113 treatment, 120 Hemophysis, remedies for, 547 Hemorrhage into labyrinth, 518 nasal, 113. See also Nasal hemorrhage. secondary, from adrenalin, 546 Hemostatic, hydrogen peroxid as, 536 Hemostatics, 545 Henpue, 99 Herpes of auricle, 357 Heryng's laryngeal lancets, knives, and curettes, 271 Hexamethelamin, 556 Hiatus semilunaris, 171 Highmore, antrum of, inflamma- tion, 158. See also Antrum of Highmore, inflammation. Hinsberg's operation for laby- rinthitis, 530 Hogge's law, 520 Holmes' nasopharyngoscope, 36 Horse cold, 107 serum in nasal hemorrhage, 547 Hot-air apparatus, 49 Hydrargyrum, 540, 541 Hydrobromic acid, 564 in hay-fever, 108 Hydrogen dioxid, 535 peroxid, 535, 536 576 INDEX Hydrorrhea, nasal, m treatment of, 112 Hyperemia of auricle, 355 of labyrinth, 516 of larynx, 260, 286 Hyperesthesia of nasal mucous membrane, 106 of pharynx, 244 Hyperkeratosis of pharynx, 230 treatment, 231 Hyperosmia, 106 Hyperostosis of external auditory canal, 370 Hyperplasia of ethmoid cells, 181 Hyperplastic rhinitis, 75 Hypertrophic rhinitis, 75 Hypertrophied angle of nasal septum, 126 Hypertrophies, anterior nasal, removal of, 78 chromic acid for, 81 galvanocautery for, 78 trichloracetic acid for, 81 posterior nasal, removal of, 82 Hypertrophy of lingual tonsil, 224 of pharyngeal tonsil, 199 of tonsils, 214 chronic, 214 galvanopuncture in, 215 soft, 214 tonsillectomy in, 217 tonsillotomy with tonsillo- tome in, 215 treatment, 215 Hypnotics, 547 Hypotympanic space, 481 Hysteric deafness, 517 Hurd's separator and pillar re- tractor, 211 Illumination of antrum of Highmore, 161 Immunity, functions of tonsils and, 198 Impached cerumen, 375 removal, 376 Impetigo contagiosa of auricle, 357 . Incudostapedial articulation sev- ering of, 442 Incus, 321, 322 malleus, and membrana tym- pani, removal of, in suppurative cases, 447 Infiltration, submucous, of nasal septum, 145 Inflammation, acute circum- scribed, of external audi- tory canal, 362 gangrenous, of neck, 233 of antrum of Highmore, 158. See also Antrum of Highmore, inflammation. of ethmoid cells, 181 Ballenger's operation, 183 Hajek's operation, 184 of frontal sinus, 169 treatment, 171 of mucous membrane of nose, 65. See also Schneider- ian membrane, inflam- mation of. of submucous tissue of larynx, 270 of uvula, 246 treatment, 247 Influenza, otitis media from, 439 Infraglottic edema, 270 laryngoscopy, 26 Infundibulum, 171 Inhaler, formulas for, 550 Inhalers, 48 bottle-, 48 Insects in external auditory canal, 371 Instruments for examination, sterilization, 50 for tracheotomy, 309 for treatment, sterilization, glass, sterilization of, 51 sterilization of, 50 Internal ear, 314, 325. See also Labyrinth. Intracranial complications of otic disease, 490 Intubation in diphtheria, 304 in diphtheria, accidents follow- ing, 306 feeding in, 308 inability to breathe after, 307 treatment of patient, 307 lodid of potassium, 540 of sodium, 540 lodin, 554 Iter chordae anterius, 320 posterius, 320 Jacobson's nerve, 323 INDEX 577 Jansen's dilator, 468 operation for inflammation of antrum of Highmore, 167 Jarvis' snare, 78 Joint, malleo-incudal, 322 Juracz's adenoid forceps, 201 Kahler tracheobronchoscope, 27 Keloid of auricle, 354 Keratosis obturans, 378 Kernig's sign in intracranial com- plications of diseases of ear, 491, 492 Killian's apparatus for suspen- sion laryngoscopy, 28 frontal sinus chisel, 168 operation for chronic purulent disease of frontal sinus, 177 speculum, 31 O'Reilly's modification, 31 Knife, Ballenger's ethmoid, 183 Ballenger's septum, 138 swivel, 141 cautery, 82 Freer's septum, 138 Myles' tonsil, 211 Korner's method of skin-grafting, , 483 Krause s nasal and laryngeal snares and curette for- ceps, 283 Kyle's operation for deviated septum, 137 Labyrinth, 314, 325 and middle-ear deafness, differ- entiation, 515 anemia of, 516 bloody discharge from, sig- nificance, 517 concussion of, 517 empyema of, 52.5 hemorrhage into, 518 hyperemia of, 516 inflammation of, 525. See also Labyrinthitis. osseous boundaries of, 325 contents of, 325 saccule of, 325 static, diseases of, 519 syphilis of, 517 utricle of, 325 Labyrinth, vestibule of, 325 Labyrinthitis, 525 circumscribed, 525, 526 differential diagnosis, 528 diffuse, 525 serous, 527 suppurative, 527 Hinsberg's operation for, 530 Neumann's operation for, 530 treatment, 529 La grippe, otitis media from, 439 Lamina papyracise, 179 reticularis, 328 spiralis ossea, 326 Laryngeal chorea, 287 cough, spasmodic, 287 crisis, 293 diphtheria, 297, 299 epilepsy, 290 image, 26 bringing into view, 23 normal, 26 mirror, 17 introduction, 22 temperature, 22 nerve, recurrent, 258 superior, 258 paralysis from aneurysm of aorta, 258 sound, 40 vertigo, 290 treatment, 291 Laryngismus stridulus, 288 treatment, 289 Laryngitis, acute, 261 treatment of, 262 chronic, 266 treatment of, 267 sicca, 268 treatment, 269 subacute, 263 treatment of, 265 syphilitica, 271 tubercular, 273 climate for, 544 differential diagnosis, 275 treatment of, 277 Laryngology, 21 Laryngopharynx, 194 Laryngoscope, 17 Killian's, 28 laryngeal mirror of, 17 reflector of, 17, 18 method of wearing, 19 578 INDEX Laryngoscopy, 21 direct, 27 advantages of, 30 infraglottic, 26 Killian's apparatus for, 28 laryngeal mirror of introduc- tion, 22 temperature, 22 light for, 19 obstacles to, 23 source of light in, 20 suspension, 27-29 tongue in, controlling, 23 Laryngotomy, 310 Laryngotracheotomy, 310 Larynx, 250 anatomy of, 250 anemia of, 260 anesthesia of, 286, 536 angioma of, 280 arteries of, 257 carcinoma of, 282 treatment, 284 cartilages of, 250 catarrh of, chronic, climate for 544 cyst of, 280 diseases of, 260 edema of, acute, 270 fibroma of, 280 foreign bodies in, 284 treatment, 285 hyperemia of, 260 hyperesthesia of, 286 leprosy of, 279 treatment, 280 ligaments of, 254 mucous membrane of, 257 muscles of, 254 myxoma of, 280 nerves of, 258 neuroses of, 286 motor, 287 sensory, 286 papilloma of, 280 paralysis of, 291. See also Paralysis of larynx. paresthesia of, 286 size of, 258 spasm of, 287 submucous tissue, inflamma- tion of, 270 syphilis of, 271 tumors of, 280 Larynx, tumors of, treatment, 281 veins of, 257 ventricles of, 257 ventricular bands, 256 Law, Ewald's, 520 Hogge's 520 Semon's, 293 Leeches in otitis media catar- rhalis acuta, 396 Leprosy of larynx, 279 treatment, 280 of nose, 102 Leprous pharyngitis, 237 Leptomeningitis, purulent, from otic disease, 501 serous, from otic disease, 495 Leukocytes, 494 Leukocytosis in intracranial com- plications of diseases of ear, 494 Levator palati muscle, 324 Ligaments of larynx, 254 Ligamentum obturatorium stape- dius, 322 Light for laryngoscopy, 19 Line, Zuckerkandl's, 187 Linea temporalis, 474 Lingual goiter, 225 tonsils, 195 diseases, 224 hypertrophy of, 224 Liquor antiseptici, 534 alkalinis, 534 argenti nitratis, 539 Little wonder pump, 45 Lobule of auricle, cleft, 354 of ear, 315 Lowenburg's method of catheteri- zation of Eustachian tubes, 345 Lozenges, 550 ammonium salts, 553 camphomenthol, 552' cocain, 553 guaiacum, 551 miscellaneous, 553 voice, 554 . Ludwig's angina, 233 treatment, 233 Lumbar puncture in intracranial complications of dis- eases of ear, 491 Lupus, 101 congestiva, 101 INDEX 579 Lupus erythematosa, 101 sebaceous, 101 superficialis, 101 vulgaris, 101 of auricle, 357 of pharynx, 238 treatment, 239 treatment, 102 Lymphatics of nose, 61 of pharynx, 195 Lymphocytes, 494 Macewen's triangle, 474 Maggots in nose, 103 Malignant growths of tonsils, best way of removing, . 197 Malleo-incudal joint, 322 Malleus, 321 axial ligament of, 321 ligaments of, 321 membrana tympani, and incus, removal of, in suppura- tive cases, 447 Martin's tonsil snare, 218 Massage of middle ear in stric- ture of Eustachian tube, 414 Masseur of Delstanche, 40 Mastoid antrum, 325 curette, Whiting's, 466 fossa, 474 gouges, Alexander's, 469 operation, 465 accidents during, 476 after-technic, 475 incision for, 467 instruments for, 465 opening horizontal semicir- cular canal in, 479 posterior cranial fossa in, 477. preparation of patient, 465, 466 radical, 480 causes of failure after, 483 skin-grafting after, 482 Ballance's method, 483 Korner's method, 483 Panse's method, 482 Passow's modifica- tion, 483 Thiersch's method, 483 Mastoid operation, radical, sinus thrombosis after skin- grafting, 504 technic, 465 wounding facial nerve in, 479 wounding lateral sinus in, 477 process, abscess in, perforation °f, 472 diploetic, 457 in adults, 456 of temporal bone, 325 pathologic importance of types, 457 pneumatic, 456 pneumodiploetic, 457 sclerosed, 457 tip of, removal, 472 Mastoiditis, 452 atypical cases, 462 caries in, 459, 460 complications, 460 etiology, 458 hearing in, 463 latent, 462 necrosis in, 459, 460 operation for, 465. See also Mastoid operation. operative cases, 461 otorrhea in, sudden cessation, 461 pathology, 458 prognosis, 465 sudden cessation of discharge in, 461 symptoms, 460 tenderness in, 462 treatment, 463 Measles, otitis media from, 438 Meati of nose, 59, 60 Membrana basilaris, 326 flaccida, 316 propria, 317 sectoria, 328 tensor, 317 tympani, 316 abscess of, 384 artificial contrivance for in- troducing, 392 Toynbee's, 392 chalk deposits on, 386 curvature of, changes in, 379 discharge from, 384 diseases of, 379 granular spots on, 384 580 INDEX Membrana basilaris, tympani in otitis media catarrhalis chronica, 408 inflammation of, 381 chronic, 383 malleus, and incus, removal of, in suppurative cases, 447 nerves of, 318 of children, examination, 455 perforation of, 388 treatment, 390 polypi on, 384 puncture of, in otitis media catarrhalis acuta, 398 rupture of, 386 treatment, 388 secundaria, 320 vessels of, 318 vibrans, 317 Membranous rhinitis, 72 semicircular canals, 328 Meniere's disease, 408, 518 Meningitis, external, from otic disease, 496 Menthol, 554 Mercury, 540, 541 bichlorid of, 534 biniodid of, 535 Metastasis, ear conditions from, 518 Middle ear, 314, 316 catarrh of. See Otitis media. cleansing of, hydrogen per- oxid for, 535 deafness and internal ear deafness, differentia- tion, 515 diseases of, 379 exenteration of, 480 inflation of, by Eusta- chian catheter, 347 massage of, in stricture of Eustachian tube, 414 of newborn, 452 operations upon, 442 Miller's asthma, 107 Mineral acids in hay-fever, 108, 549 Mirror, laryngeal, 17 introduction of, 22 temperature of, 22 Mixture, "l, 2, 3," 540 Mixtures, cough, 542 Motor neuroses of larynx, 287 of nose, 105 Mouth-breather, 76 Mucocele of frontal sinus, 181 Mucous membrane of larynx, 257 of nose, 60. See also Schneiderian membrane. of pharynx, 194 remedies for cleansing, 533 Music, 330 Musical notes, 258 loudness of, 259 qualities of, 259 Muscles of auricle of ear, 315 of epiglottis, 256 of Eustachian tube, 324 of larynx, 254 of nose, 58 of pharynx, 194 of tympanum, 322 Mycosis of external auditory canal, 368 of pharynx, 230 Myiasis, nasal, 103 treatment of, 104 Myles' tonsil knife, 211 punches, 215 Myringitis, 381 chronic, 383 treatment of, 383 Myxoma of larynx, 280 Nares, 30 congenital occlusion, 141 treatment, 142 Nasal cavities, 58 diphtheria, 297, 299 genital spots, 107 hemorrhage, 113 adrenalin in, 117 Bellocq's cannula in, 120 etiology, 113 horse serum in, 547 in diphtheria, 300 pathology, 115 pressure-cone for, 118 prognosis, 115 recurrent, 116 remedies for, 547 treatment, 115 hydrorrhea, in tieatment, 112 myiasis, 103 treatment, 104 INDEX 581 Nasal saws, 88 Bosworth's, 88 Bucklin's, 88 Hall's, 88 Sajous', 88 septum, 56, 57 abscess of, 144 deviation of, 125 Bosworth's operation for, .130 etiology, 125 Gleason's operation for, 130 Ballenger's modifica- tion, 136 modifications, 136 Price and Brown's operation, for, 136 Kyle's operation for, 137 operations for, 130 factors interfering with, 129 pathology, 127 submucous resection for, 138 symptoms, 127 diseases of, 125 dislocation, 145 ecchondroses of, 85 treatment, 86-90 exostoses of, 85 treatment, 86-90 hematoma of, 143 treatment, 144 hypertrophied angle of, 126 perforation of 144 treatment, 145 provisional callus of, 126 redundancy of, 129 resiliency of, 130 submucous infiltration, 145 space, posterior, 194 speculum, 31 splint, Carter's, 146 tubes, Gleason's, 135 Nasopharyngeal fibroma, 121, 123 Nasopharyngoscope, Holmes', 36 Nasopharynx, 30, 194 diseases of, 199 Nebulizer, 47 Nebulizers, formulas for, 557 Neck, gangrenous inflammation, Necrosis in mastoiditis, 459, 460 of temporal bone, 430 Nerves of auricle of ear, 315 of Eustachian tube, 325 of larynx, 258 of membrana tympani, 318 of nasal fossae, 61 of nose, 58 of pharynx, 194 of tympanum, 323 Neumann's operation for laby- rinthitis, 530 Neuroses of larynx, 286 motor, 287 sensory, 286 of nose, 105 motor, 105 reflex, 106 sensory, 106 of pharynx, 243 Neutrophiles, 494 Newborn, external ear of, 452 facial nerve in, 455 middle ear of, 452 osseous canal in, 455 Shrapnell's membrane in, 455 temporal bone of, 454 Nitric acid in aphonia, 549 Nitromuriatic acid in hay-fever, 108, 549 Noises, 330 Nose, 56 accessory sinuses, diseases of, 150 differentiation, 155 inflation, by Valsalva's method, 163 operations on, accidents and dangers of, 191 alse of, 56 anatomy of, 56 angioma of, 121 arteries of, 58 bony arch, 56 framework, injuries and de- formities, 145 bridge of, flattening, 146 bulbous enlargement of end, Rodman's operation for, 150 Roe's operation for, 150 carcinoma of, 121, 125 treatment, 125 cartilaginous arch, 56 582 INDEX Nose, catarrh of, chronic, cli- mate for, 544 cavities of, 58 cyst of, 121, 123 deformities of, congenital, 149 diseases of, 66 causing disease of ear, 339 effect on other parts of body, 66 dog, 99 ecchondroma of, 121 erectile tissue, 60 examination of, 53 exostosis of, 121 external, 56 fibroma of, 121, 123 foreign bodies in, 104 fossae of arteries, 61 nerves, 61 leprosy of, 102 lymphatics of, 61 maggots in, 103 meati of, 59, 60 mucous membrane, 60. See also Schneiderian mem- brane. muscles of, 58 nerves of, 58 neuroses of, 105. See also Neuroses of nose. olfactory region, 60 osteoma of, 85, 121 packing of, after operation, 90 papilloma of, 121, 124 polypus of, 121 treatment, 122 pug, 58 respiratory region, 60 saddle-back, 146 sarcoma of, 121, 124 skin covering, 58 sterilization of, 52 triangular cartilage, 57 tumors of, 121 turbinated bones of, 59 twitching of, 105 vestibular region, 60 wings of, 56 Nosebleed, 113. See also Nasal hemorrhage. Novargan, 563 Nozzles, hard-rubber, steriliza- tion of, 51 Nystagmus, 520 cerebellar, 521 vestibular, 520 caloric tests for, 523 electric tests for, 524 finger test for, 523 fistula test for, 525 functional tests for, 522 horizontal, 520 oblique, 520 production of, by turning, 522 rotary, 520 spontaneous, 521 vertical, 520 Octave, definition, 333 O'Dwyer's intubation set, 304 Oil, phosphorated, 554 Ointments, 560 Operator, preparation of, 52 Ophthalmocutaneous diagnostic reactions in tuberculo- sis, 557 O'Reilly's modification of Killian's speculum, 31 Organ of Corti, 328 Oropharynx, 194 diseases of, 206 Orthoform, 562 Osseous canal in newborn, 455 Ossicles, 320 Osteoma of external auditory canal, 370 of nose, 85, 121 Ostium frontale, 171 Othematoma of auricle, 352 Otitis externa crouposa, 369 diffusa acuta, 365 chronica, 366 diphtheritica, 368 hasmorrhagica, 366 media catarrhalis acuta, 392 bacteriology, 395 dry heat in, 397 etiology, 393 leeches in, 396 pathology, 394 Politzer's air-bag in, 398 prognosis, 395 puncture of drum-head in, 398 symptoms, 396 treatment, 396 chronica, 402 INDEX 583 Otitis media catarrhalis chronica, deafness in, 405 etiology, 404 head noises in, 407 hearing in, 405 membrana tympani in, 408 otosclerosis in, 404, 408 patency of Eustachian tube in, 410 pathology, 402 prognosis, 410 symptoms, subjective, 405 tinnitus in, 407 treatment, 411 vertigo in, 408 subacuta, 400 adenoids complicating, 400 inflammation of mucous glands in, 401 from Bright's disease, 441 from debility, 442 from diabetes, 441 from diphtheria, 438 from excessive fatigue, 442 from influenza, 439 from la grippe, 439 from measles, 438 from pneumonia, 441 from scarlatina, 437 from syphilis, 441 from tuberculosis, 440 from typhoid fever, 439 suppurativa acuta, 418 treatment, 420 chronica, 422 cleansing ear in, 426 deafness in operation for, 446 otorrhea in, 425 tinnitus from, operation for, 446 treatment, 425 systemic diseases causing, 437 Otoliths, 328 Otomycosis, 368 Otorrhea in diphtheria, 301 in otitis media suppurativa chronica, 425 sudden cessation, in mastoidi- tis, 461 Otosclerosis, 404, 408 treatment, 412 Otoscopic reflector, 36 Otoscopy, 36 obstacles to, 38 reflector in, 36 relative positions of patient and observer in, 37 specula for, 36 method of introducing, 37 Oval window of tympanum, 320 Ozena, 92 Packing nose after operation, 90 Palate, hard, 60 Panlabyrinthitis, 525 Pause's method of skin-grafting, 482 Passow's modification, 483 Papilloma of larynx, 280 of nose, 121, 124 Paracusis diplacusis, 406 duplicata, 406 Willisii, 406 Paraffin, 555 prothesis, 147 syringe for, 147 subcutaneous injection, 555 syringe, Smith's, 147 Paralabyrinthitis, 525 Paraldehyd, 547 Paralysis, Bell's, from otic dis- ease, 509 diphtheritic, 299 facial, from otic disease, 509. See also Facial paralysis. of larynx, 291 abductor, 291, 293 spasmodic, 293 from aneurysm of aorta, 258 treatment, 295 of pharynx, 245 of tensors of vocal cords, 287, 294 Paresthesia of larynx, 286 of nasal mucous membrane, 106 of pharynx, 244 Parosmia, 106, 158 Passow's modification of Panse's method of skin-grafting, 483 584 INDEX Patency of Eustachian tube, 341. See also Eustachian tube, patency of. of Eustachian tube in chronic otitis media, 410 Patients, examination of, 53 Peach cold, 107 Pendulum vibration, 331 Perceptive apparatus, diseases of, .515 Perforation of abscess in mastoid, 472 of membrana tympani, 388 treatment, 390 of nasal septum, 144 treatment, 145 whistle, 388, 422 Pericarditis in diphtheria, 301 Perichondritis of auricle, 352 chronic, 353 Perilabyrinthitis, 525 Perilymph, 326 Perimeningitis from otic disease, 496 Peritonsillar abscess, 211 treatment, 212 Petrolatum as nebulizer, 558 Petrosal artery, 323 Pharyngeal aponeurosis, 193 mouths of Eustachian tubes, 34i tonsil, 195 adenoid vegetations of, 199 hypertrophy of, 199 Pharyngitis, acute, 225 treatment of, 225 atrophic, 229 treatment of, 230 chronic, 226 treatment of, 226 follicular, 226 chronic, 227 leprous, 237 phlegmonous, 232 treatment of, 232 syphilitic, 236 treatment of, 237 tubercular, 238 Pharynx, 193 actinomycosis of, 240 treatment, 241 anatomy of, 193 anesthesia of, 243 arteries of, 194 Pharynx, attachments of, 194 catarrh of, chronic, climate for, 544 diseases of, causing disease of ear, 339 divisions of, 194 equinia of, 239 erysipelas of, 231 treatment, 232 farcy of, 239 foreign bodies in, 245 treatment, 246 glanders of, 239 hyperesthesia of, 244 hyperkeratosis of, 230 treatment, 231 leprosy of, 237 lupus vulgaris of, 238 treatment, 239 lymphatics of, 195 mucous membrane of, 194 muscles of, 194 mycosis of, 230 nerves of, 194 . neuroses of, 243 paralysis of, 245 paresthesia of, 244 relations of, 193 syphilis of, 236 tuberculosis of, 238 tumors of, 243 ulcer of simple, 235 simple, treatment of, 236 Phlegmonous erysipelas of au- ricle, 360 pharyngitis, 232 treatment, 232 tonsillitis, 213 Phonomassage in stricture of Eustachian tube, 415 Phosphorated oil, 554 Phthisis, chronic fibroid, climate for, 544 Pigments, 561 Pilocarpin, 556 Pinna, 314. See also A uricle. Piston-syringe, 40 Pitch, 259, 332 Pitcher-shaped cartilages, 252 Pituitary membrane, 60 Pleurisy in diphtheria, 301 Plexus, tympanic, 323 Pneumatic mastoid, 456 Pneumodiploetic mastoid, 457 INDEX 585 Pneumomassage in stricture of Eustachian tube, 415 Pneumonia, otitis media from, 451 Poisoning, cocain, 538 Politzer's air-bag, 343 in otitis media catarrhalis acuta, 398 ear forceps, 385 test of patency of Eustachian tubes, 342 Pollantin in hay-fever, 111 Polypus, aural, 428 removal of, anesthesia for, 537 nasal, 121 treatment of, 122 on membrana tympani, 384 snare, Blake's, 421 Postnasal catarrh, 199 space, 30 diseases of, 199 Potassium iodid, 540 Powder-blower, 49 Davidson's, 49 Pressions centripetes, 337 Pressure symptoms in intra- cranial complications of diseases of ear, 492 Pressure-cone for nasal hemor- rhage, 118 Price and Brown's modification of Gleason's operation for deviated septum, 136 Probe, Allen's, 41 as applicator in Eustachian tube, 349 for removing cerumen, 374 Skillern's sinus, 173 Processus auditorius, 455 cochleariformis, 320 Protargol, 539 Protectives, 564 Protector, Stacke's, 474 Prothesis, paraffin, 147 syringe for, 147 Provisional callus of nasal sep- tum, 126 Prussak's space, 317 Pseudacousma, 407 Pseudomembranous uvulitis, 246 Pug nose, 58 Pulmonary tuberculosis, climate for, 544 Pump, Little Wonder, 45 Punches, Myles' tonsil, 215 Puncture, lumbar, in intracranial complications of dis- eases of ear, 491 of drum-head in otitis media catarrhalis acuta, 398 Purpura, 113 treatment, 120 Purulent leptomeningitis from otic disease, 501 rhinitis, 71 Pynchon's cabinet, 47 Pyriform arytenoids, 275 Ragged tonsil, 214 Recessus epitympanicus, 318 Recurrent laryngeal nerve, 258 Reflector of laryngoscope, 17, 18 method of wearing, 19 otoscopic, 36 Reflex nasal neuroses, 106 Reissner's membrane, 327 Resection, submucous, for devi- ated septum, 138 Retropharyngeal abscess, 241 treatment, 242 Rhinitis, acute, 67 atrophic, 91 etiology of, 91 Gottstein's treatment, 93 pathology of, 92 prognosis of, 96 symptoms of, 93 treatment of, 93 chemic, 63 chronic, simple, 69 hyperplastic, 75 hypertrophic, 75 membranous, 72 purulent, 71 syphilitic, 96 treatment of, 97 tubercular, 100 treatment of, 101 turgescent, 69 Rhinoliths, 104 treatment of, 105 Rhinorrhea, cerebral, 113 Rhinoscleroma, 102 Rhinoscopy, 30 anterior, 30, 32 posterior, 30, 33 image in, 35 586 INDEX Rhinoscopy, posterior, obstacles .to, 34 technic of, 30 Rima glottidis, 27, 256 Rinne's test for hearing, 335 Rivini's foramen, 379, 389 Rodman's operation for bulbous enlargement of end of nose, 150 Rods of Corti, 328 Roe's operation for bulbous en- largement of end of nose, 150 Rose cold, 107 Round window of tympanum, 320 Rupture of membrana tympani, 386 treatment, 388 Saccule of labyrinth, 325 Sacculus laryngis, 257 Saddle-back nose, 146 Sajous' saw, 88 Salt solution, normal, 534 Salvarsan, 540 Santorini, cartilages of, 253 cartilages, 27 Sarcoma of nose, 121, 124 Saws, nasal, 88 nasal, Bosworth's, 88 Bucklin's, 88 Hall's, 88 Sajous', 88 Scala media, 327, 328 tympani, 327 vestibuli, 326, 327 Scarlatina, otitis media from, 437 Scarlet Red, 557 ointment in atrophic rhinitis, 95 Schneiderian membrane, 60 anesthesia of, 106 hyperesthesia of, 106 inflammation of, 65 catarrhal, acute, 65 chronic, 65 croupous, 65 diphtheritic, 66 paresthesia of, 106 pathology, 62 physiology, 62 Schwabach's test for hearing, 337 Scirrhous tonsil, 214 Scissors, Beckmann's, 85 Sclerosed mastoid, 457 Scute of tympanum, 318 Sedatives, 564 local, 565 Seiler's septum knife, 133 Semicircular canals, function of, 329 membranous, 328 Semon's law, 293 Sensory neuroses of larynx, 286 of nose, 106 Septum knife, Ballenger's, 138 Freer's, 138 Seiler's, 133 nasal, 56, 57. See Nasal sep- tum. Serum, horse, in nasal hemor- rhage, 547 treatment of diphtheria, 303 of hemophilia, 120 Sesamoid cartilage, 56 Sessile exostoses of external audi- tory canal, 370 Sharpnell's membrane, 316 in newborn, 455 Siegle's pneumatic speculum, 39 Sign, Babinski's, in intracranial complications of dis- eases of ear, 491 Kernig's, in intracranial com- plications of diseases of ear, 491, 492 Silver nitrate, 539 in atrophic rhinitis, 95 Simpson's intranasal tampon, 116 Singing voice, 260 Sinks, 47 Sinus probe, Skillern's 173 thrombosis after mastoid opera- tion, 504 from otic disease, 503 Skillern-Hajek sphenoid punch, 189 Skillern's evulsor, 190 modification of Hajek's opera- tion for empyema of sphenoidal cells, 189 sinus probe, 173 Skin covering nose, 58 diseases of auricle, 354 tests for tuberculosis, 557 INDEX 587 Skin-grafting after radical mas- toid operation, 482 Ballance's method, 483 Korner's method, 483 Pause's method, 482 Passow's modifica- tion, 483 Thiersch's method, 483 Smell, loss of sense of, 106 Smith's paraffin syringe, 147 Snare, Blake's polypus, 421 Jarvis', 78 Martin's tonsil, 218 Sneezing, definition of, 67 Snow cold, 107 Sodium iodid, 540 Soft spot of antrum of Highmore, 161 Soft-rubber tubes, sterilization, 51 ulcer syringe, 43 Sore throat, clergyman's, 227 Sound, 330 laryngeal, 40 sources of, 330 Spasm of adductor muscles, 288 of larynx, 287 Spasmodic abductor paralysis, 293 laryngeal cough, 287 Speculum, Allen's, 32 Boucheron's, 37 ear, 36 for otoscopy, 36 method of introducing, 37 Foster's, 140 Gleason's, 32 Killian's, 31 O'Reilly's modification, 31 nasal, 31 Siegle's pneumatic, 39 Sphenoid punch, Skillern-Hajek, 189 Sphenoidal cells, empyema of, 186 Hajek's operation, 188 Skillern's modifica- tion, 189 treatment, 187 Spittoon, swinging, 47 Splint, Carter's nasal, 146 Spoke shave, 83 Spot, soft, of antrum of High- more, 161 Spots, granular, on membrana tympani, 384 Sprays, 533 Stacke's protector, 474 Stapedius muscle, 323 Stapes, 321, 322 extraction of, 442 mobilizing of, 442 Static labyrinth, diseases of, 519 Sterilization of atomizers, 52 of glass instruments, 51 of hard-rubber nozzles, 51 of instruments, 50 of nose, 52 of soft-rubber tubes, 51 of syringes, 51 Stethoscope, aural, 341 Stimulated disharmony, 526 Stirrup bone of ear, 321, 322 Stovain as local anesthetic, 537 Stricture of Eustachian tube, 413. See also Eustachian tube, stricture of. Struycken's forceps, 84 Stylomastoid artery, 323 Subacute laryngitis, 263 treatment, 265 Subdural abscess from otic dis- ease, 496 Submerged tonsil, 214 Submucous infiltration of nasal septum, 145 resection for deviated septum, I38 tissue of larynx, inflammation, 270 Sullivan's frontal sinus rasps, 173 Sulphonal, 547 Suppuration of ethmoid cells, 181 Suprameatal triangle, 474 Supravomerine cartilage, 57 Suspension laryngoscopy, 27-29 Swinging spittoon, 47 Syphilis of auricle, 358 of labyrinth, 517 of larynx, 271 otitis media from, 441 Syphilitic laryngitis, 271 pharyngitis, 236 treatment, 237 rhinitis, 96 treatment, 97 Syringe, ear, soft-rubber, 43 eye, soft-rubber, 43 588 INDEX Syringe, piston-, 40 Smith's paraffin, 147 sterilization of, 51 ulcer, soft-rubber, 43 with interchangeable nozzles, „ 44 Systemic diseases causing otic inflammation, 437 Tache ceffibrale, 501 Tampon, Simpson's intranasal, 116 Tegmen tympani, 319 Temporal bone, caries of, 430 mastoid process of, 325 necrosis of, 430 of newborn, 454 Tensor palati, 324 tympani, 322 Tensors of vocal cords, paralysis of, 287, 294 Tests, caloric, for nystagmus, 523 conjunctival in tuberculosis, . 557 electric, for nystagmus, 524 finger, for nystagmus, 523 fistula, for nystagmus, 524 for hearing, 54, 330. See also Hearing, tests for. functional, for nystagmus, 522 skin, for tuberculosis, 557 Thiersch's method of skin-graft- ing, 483 Thiosinamin, 541 Thornwaldt's disease, 206 Throat, clergyman's sore, 227 Thrombosis, sinus, after mastoid operation, 504 from otic disease, 503 Thyro-arytenoideus muscle, 255 Thyroid cartilage, 250 Thyrotomy, 285 Timbre, 259, 331 Tinnitus from otitis media sup- purativa chronica, oper- ation for, 446 in otitis media catarrhalis chronica, 407 in stricture of Eustachian tube, 416 Tone, 331 intensity of, 331 pitch of, 332 quality of, 331 Tongue, control of, in laryngo- scopy, 23 examination of, 53 Tongue-depressor, Bosworth's, 25 Tonics, 566 Tonsillar gland, 196 Tonsillectomy for hypertrophied tonsils, 217 Tonsillitis, acute, 206 croupous, 206 follicular, acute, 2 06 treatment of, 209 chronic, 210 treatment of, 210 phlegmonous, 213 Tonsillotome, Ermold's, 216 tonsillotomy with, for hyper- trophied tonsils, 215 Tonsillotomy with tonsillotome for hypertrophied ton- sils, 215 Tonsils, 195 blood-supply of, 197 buried, 214 crypts of, 196 cyst of, 214 faucial, 195 functions of, 197 immunity and, 198 hard, 214 hypertrophy of, 214 chronic, 214 galvanopuncture in, 215 soft, 214 tonsillectomy in, 217 tonsillotomy with tonsillo- tome in, 215 treatment, 215 knife, Myles', 211 lingual, 195 diseases of, 224 hypertrophy of, 224 local anesthesia of, 537 malignant growths, best way of removing, 197 pharyngeal, 195 adenoid vegetations of, 199 hypertrophy of, 199 punches, Myles', 215 ragged, 214 scirrhous, 214 snare, Martin's, 218 submerged, 214 tubal, 195 INDEX 589 Toynbee's artificial drum-head 392 auscultation-tube, 342 Tracheobronchoscope, Kahler, 27 Tracheoscopy, direct, 29 Tracheotomy, 308 anesthetic in, 308 high operation, 308, 310 instruments for, 309 low operation, 308, 310 preparation of patient, 309 Tracheotomy-tube, 312 Triangle, Macewen's, 474 suprameatal, 474 Troutman's, 499 Triangular cartilage of nose, 57 Trichloracetic acid, 542 in treatment of anterior nasal hypertrophies, 81 Trional, 547 Troutman's triangle, 499 Tubal tonsils, 195 Tubercular laryngitis, 273 climate for, 544 differential diagnosis, 275 treatment, 277 pharyngitis, 238 rhinitis, 100 treatment, 101 Tuberculosis, conjunctival reac- tion in, 557 cutaneous reaction in, 557 of pharynx, 238 otitis media from, 440 pulmonary, climate for, 544 skin tests in, 557 Tumors of larynx,' 280 treatment, 281 of nose, 121 of pharynx, 243 Tuning-forks, 332, 333 Turban-shaped epiglottis, 275 Turbinated bones, 59 Turbinectomy, 83, 84 Turbinotomy, 83 Turgescent rhinitis, 69 Twitching of nose, 105 Tympanic plexus, 323 Tympanum, arteries of, 323 atrium of, 318 attic of, 318 cavity of, 318 diseases of, 392 floor of, 319 Tympanum, inner wall of, 320 muscles of, 322 nerves of, 323 outer wall of, 319 oval window of, 320 plexus of, 323 roof of, 319 round window of, 320 scute of, 318 Typhoid fever, otitis media from, 439 Ulcer of pharynx, simple, 235 treatment of, 236 syringe, soft-rubber, 43 Ulceration of uvula, 247 Urotropin, 556 Useless cough, 228- Utricle of labyrinth, 325 Uvula, bifid, 247 deformities of, 247 diseases of, 246 elongation of, 248 inflammation of, treatment, 247 ulceration of, 247 Uvulitis, 246 pseudomembranous, 246 Valsalva's method of inflating accessory sinuses, 163 test of patency of Eustachian tubes, 341 Vegetations, adenoid, of pharyn- geal tonsil, 199 Veins of auricle of ear, 315 of larynx, 257 Ventricles of larynx, 257 Ventricular bands of larynx, 256 Vernix caseosa, 452 Vertigo in otitis media catarrhalis chronica, 408 laryngeal, 290 treatment of, 291 Vestibular apparatus, diseases of, 5i9 function of, 329 nystagmus, 520. See also Nys- tagmus, vestibular. Vestibule of labyrinth, 325 Vibration, pendulum, 331 Vibrations, aerial, 330 Vincent's angina, 234 treatment, 235 590 INDEX Vocal cords, 256 false, 256 tensors of, paralysis, 287, 294 true, 256 Voice, 258, 259 falsetto, 259 in testing hearing, 339 lozenges, 554 production, 258 qualities of, 259 range of, 259 singing, 260 timbre of, 259 Vomerine cartilage, 57 crest, 58 Washes, 533 . Watch in testing hearing, 338 Water-pump for compressed air, , 45 Weber s test for hearing, 334 Whistle, Edelmann-Galton, 332 perforation, 388, 422 Whiting's encephaloscope, 500 mastoid curette, 466 Wounds of auricle of ear, 353 Wrisberg's cartilages, 27, 253 Xeroform, 563 Ya ws, 99 Zinc chlorid, 542 Zuckerkandl's line, 187 SAUNDERS' BOOKS on GYNECOLOGY and OBSTETRICS W. B. SAUNDERS COMPANY West Washington Square Philadelphia 9, Henrietta Street Covent Garden, London Our Handsome Complete Catalogue will be Sent on Request Norris' Gonorrhea in Women Gonorrhea in Women. By Charles C. Norris, M. D., Instructor in'Gynecology, University of Pennsylvania. With an Introduction by John G. Clark, M. D., Professor of Gynecology, University of Pennsylvania. Large octavo of 520 pages, illus- trated. Cloth, $6.00 net; Half Morocco, $7.50 net. FOR PHYSICIAN, SURGEON, SPECIALIST, AND SOCIOLOGIST Dr. Norris has neglected no phase of his subject. First you get an in- tensely interesting Historic Narrative ; then the Bacteriology and Pathogenesis, giving you the best cultural and staining methods. The civic side is very fully considered, giving you the various methods employed by the govern- ments of Europe and the Orient for the limitation and suppression of the social evil, and the situation as it is to-day in the United States. So down to the minute is the book that the work of the Chicago Vice Commission and the even more recent municipal instigations of New York and Philadelphia are included. Both operative and medicinal treatments are taken up, including a noteworthy discussion of serum and vaccine therapies. A special chapter is devoted to the drugs used in treating gonorrhea, giving formulas, solutions, etc. DISEASES OF WOMEN DeLee's New Obstetrics Text=Book of Obstetrics. By Joseph B. DeLee, M. D., Professor of Obstetrics at Northwestern University Medical School, Chicago. Large octavo of 1060 pages, with 913 illus- trations, 150 in colors. Cloth, $8.00 net; Half Morocco, $9.50 net. FOUR PRINTINGS You will pronounce this new book the most elaborate, the most superbly illustrated work on Obstetrics you have ever seen. Especially will you value the 913 illustrations, all, with but few exceptions, original, and the best work of leading medical artists. Some 150 of these illustrations.are in color. Such a magnificent collection of obstetric pictures-and with really practical vatue-has never before appeared in one book. You will find the text extremely practical throughout. Diagnosis is fea- tured, and the relations of obstetric conditions and accidents to general medi- cine, surgery, and the specialties are brought into prominence. Regarding Treatment: You get here the very latest advances in this field, and you can rest assured every method of treatment, every step in operative technic, is just right. Dr. DeLee's twenty-one years' experience as a teacher and obstetrician guarantees this. Worthy of your particular attention are the descriptive legends under the illustrations. These are unusually full, and by studying the pictures serially with their detailed legends you are better able to follow the operations than by referring to the pictures from a distant text-the usual method. Prof. W. Stoeckel, Kiel, Germany " Dr. DeLee's Obstetrics deserves the greatest recognition. The whole work is of such sterling character through and through that it must be ranked with the best works of our literature." 2 OBSTETRICS Davis' Manual of Obstetrics Manual of Obstetrics. By Edward P. Davis, M. D., Professor of Obstetrics in Jefferson Medical College, izmoof 463 pages, with 171 original illustrations. Cloth, $2.25 net. JUST ISSUED Dr. Davis' manual is a concise text-book of exceptional value. Dr. Davis, himself a teacher of many years' experience, knows the requirements of such a work and has here supplied them. You get anatomy of the normal and ab- normal bony pelvis, physiology of impregnation, anatomy of the birth canal in pregnancy, growth and development of the embryo. You get a full and clear discussion of pregnancy-its diagnosis, physiology, hygiene, pathology. You get the causes and treatment of labor, the physiology, conduct, pathology; the puerperal period-care of the mother and child ; obstetric surgery, fetal pathology, mixed feeding, and medicolegal aspects of obstetric practice. Davis' Operative Obstetrics Operative Obstetrics. By Edward P. Davis, M. D., Pro- fessor of Obstetrics at Jefferson Medical College, Philadelphia. Octavo of 483 pages, with 264 illustrations. Cloth, $5.50 net; Half Morocco, $7.00 net. INCLUDING SURGERY OF NEWBORN Dr. Davis' new work on Operative Obstetrics is a most practical one, and no expense has been spared to make it the handsomest work on the subject as well. Every step in every operation is described minutely, and the technic shown by beautiful new illustrations. The section given over to surgery of the newborn you will find unusually valuable. It gives you much informa- tion you want to know-facts you can use in your work every day. There is an excellent chapter on anesthesia in obstetrics. The Lancet, London " The best and most interesting part of the book is the summary of results given at the end of the chapters and compiled from the author's own experience and from the literature." 3 4 SAUNDERS' BOOKS ON Ashton's Practice of Gynecology The Practice of Gynecology. By W. Easterly Ashton, M.D., LL.D., Professor of Gynecology in the Medico-Chirurgi- cal College, Philadelphia. Handsome octavo volume of noo pages, containing 1058 original line drawings. Cloth, $6.50 net; Half Morocco, $8.00 net. THE NEW (5th) EDITION Among the important new matter may be mentioned the De Keating-Hart fulguration treatment, Coley's mixed toxins for sarcoma of the genito-urinary organs, the cutireaction of von Pirquet in the diagnosis of tuberculosis, " 606 " for syphilis, the hormone theory, the Fowler-Murphy treatment of suppurative peritonitis, tincture of iodin in sterilization, and Baldy's new round ligament operation for retrodisplacement. Nothing is left to be taken for granted, the author not only telling his readers in every instance what should be done, but also precisely how to do it. A distinctly original feature of the book is the illustrations, numbering 1058 line drawings made especially under the author's personal supervision. From its first appearance Dr. Ashton's book set a standard in practical medical books ; that he has produced a work of unusual value to the medical practitioner is shown by the demand for new editions. Howard A. Kelly, M. D., Professor of Gynecologic Surgery, Johns Hopkins University * " It is different from anything that has as yet appeared. The illustrations are particu- larly clear and satisfactory. One specially good feature Js the pains with which you describe so many details so often left to the imagination. Charles B. Penrose, M. D., Formerly Professor of Gynecology, University of Pennsylvania. " I know of no book that goes so thoroughly and satisfactorily into all the details of everything connected with the subject. In this respect your book differs from the others." George M. Edebohls, M.D. Professor of Diseases of Women, New York Post-Graduate Medical School. « I have looked it through and must congratulate you upon having produced a text- book most admirably adapted to teach gynecology to those who must get their knowledge, even to the minutest and most elementary details, from books." GYNECOLOGY. Bandler's Medical Gynecology Medical Gynecology. By S. Wyllis Bandler, M. D., Adjunct Professor of Diseases of Women, New York Post- Graduate Medical School and Hospital. Octavo of 790 pages, with 150 original illustrations. Cloth, $5.00 net; Half Morocco, $6.50 net. NEW (3d) EDITION-60 PAGES ON INTERNAL SECRETIONS This new work by Dr. Bandler is just the book that the physician en- gaged in general practice has long needed. It is truly the practitioner1 s gyne- cology-planned for him, written for him, and illustrated for him. There are many gynecologic conditions that do not call for operative treatment; yet, because of lack of that special knowledge required for their diagnosis and treatment, the general practitioner has been unable to treat them intelligently. This work gives just the information the practitioner needs. American Journal of Obstetrics " He has shown good judgment in the selection of his data. He has placed most emphasis on diagnostic and-therapeutic aspects. He has presented his facts in a manner to be readily grasped by the general practitioner." Bandler's Vaginal Celiotomy Vaginal Celiotomy. By S. Wyllis Bandler, M. D. Octavo of 450 pages, with 148 illustrations. Cloth, $5-°° net- SUPERB ILLUSTRATIONS The vaginal route, because of its simplicity, ease of execution, absence of shock, more certain results, and the opportunity for conservative measures, constitutes a field which should appeal to all surgeons, gynecologists, and obstetricians. Posterior vaginal celiotomy is of great importance in the re- moval of small tubal and ovarian tumors and cysts, and is an important step in the performance of vaginal myomectomy, hysterectomy, and hystero- myomectomy. Anterior vaginal celiotomy with thorough separation of the bladder is the only certain method of correcting cystocele. The Lancet, London " Dr. Bandler has done good service in writing this book, which gives a very clear description of all the operations which may be undertaken through the vagina. He makes out a strong case for these operations." 5 6 SAUNDERS' BOOKS ON Hirst's Obstetrics The New (7th) Edition A Text-Book of Obstetrics. By Barton Cooke Hirst, M. D., Professor of Obstetrics in the University of Pennsylvania. Handsome octavo, 1025 pages, with 900 illustrations, 46 in colors. Cloth, $5.00 net; Half Morocco, $6.50 net. INCLUDING RELATED GYNECOLOGIC OPERATIONS Immediately on its publication this work took its place as the leading text- book on the subject. Both in this country and abroad it is recognized as the most satisfactorily written and clearly illustrated work on obstetrics in the language. The illustrations form one of the features of the book. They are numerous and the most of them are original. In this edition the book has been thoroughly revised. Recognizing the inseparable relation between ob- stetrics and certain gynecologic conditions, the author has included all the gynecologic operations for complications and consequences of childbirth, together with a brief account of the diagnosis and treatment of all the path- ologic phenomena peculiar to women. British Medical Journal " The illustrations in Dr. Hirst's volume are far more numerous and far better exe. cuted, and therefore more instructive, than those commonly found in the works of writers on obstetrics in our own country." Hirst's Diseases of Women A Text-Book of Diseases of Women. By Barton Cooke Hirst, M. D. Octavo of 745 pages, 701 illustrations, many in colors. Cloth, $5.00 net; Half Morocco, $6.50 net. SECOND EDITION As diagnosis and treatment are of the greatest importance in considering diseases of women, particular attention has been devoted to these divisions. The palliative treatment, as well as the radical operation, is fully described, enabling the general practitioner to treat many of his own patients without referring them to a specialist. Medical Record, New York "Its merits can be appreciated only by a careful perusal. . . Nearly one hundred passes are devoted to technic, this chapter being in some respects superior to the descrip- tions in other text-books." GYNECOLOGY. Kelly and Noble's Gynecology and Abdominal Surgery Gynecology and Abdominal Surgery. Edited by Howard A. Kelly, M. D., Professor of Gynecology in Johns Hopkins University; and Charles P. Noble, M.D., formerly Clinical Professor of Gynecology in the Woman's Medical College, Phila- delphia. Two imperial octavo volumes of 950 pages each, con- taining 880 illustrations, mostly original. Per volume : Cloth, $8.00 net; Half Morocco, $9.5° net. BOTH VOLUMES NOW READY WITH 880 ORIGINAL ILLUSTRATIONS BY HERMANN BECKER AND MAX BRODEL In view of the intimate association of gynecology with abdominal surgery the editors have combined these two important subjects in one work. For this reason the work will be doubly valuable, for not only the gynecologist and general practitioner will find it an exhaustive treatise, but the surgeon also will find here the latest technic of the various abdominal operations. It possesses a number of valuable features not to be found in any other publication cover- ing the same fields. It contains a chapter upon the bacteriology and one upon the pathology of gynecology, dealing fully with the scientific basis of gyne- cology. In no other work can this information, prepared by specialists, be found as separate chapters. There is a large chapter devoted entirely to .medical gynecology, written especially for the physician engaged in general practice. Heretofore the general practitioner was compelled to search through an entire work in order to obtain the information desired. Abdominal sur- gery proper, as distinct from gynecology, is fully treated, embracing operations upon the stomach, upon the intestines, upon the liver and bile-ducts, upon the pancreas and spleen, upon the kidney, ureter, bladder, and the peritoneum. Special attention has been given to modern technic. The illustrations are the work of Mr. Hermann Becker and Mr. Max Brbdel. American Journal of the Medical Sciences " It is needless to say that the work has been thoroughly done : the names of the authors and editors would guarantee this ; but much may be said in praise of the method of presen- tation. and attention mav be called to the inclusion of matter not to be found elsewhere." 7 SAUNDERS' BOOKS ON GET the new the best nmencan standard Illustrated Dictionary The New (7th) Edition, Reset The American Illustrated Medical Dictionary. A new and complete dictionary of the terms used in Medicine, Surgery, Dentistry, Pharmacy, Chemistry, Veterinary Science, Nursing, and all kindred branches; with over 100 new and elaborate tables and many handsome illustrations. By W. A. Newman Dorland, M.D., Editor of " The American Pocket Medical Dictionary." Large octavo, 1105 pages, bound in full flexible leather. Price, $4.50 net; with thumb index, $5.00 net. A KEY TO MEDICAL LITERATURE Gives a Maximum Amount of Matter in a Minimum Space ENTIRELY RESET-5000 NEW WORDS This edition is not a makeshift revision. The editor and a corps of expert assistants have been working on it for two years. Result-a thoroughly down- to-the-minute dictionary, unequalled for completeness and usefulness by any other medical lexicon published. It meets your wants. It gives you all the new words, and in dictionary service new words are what you want. Then, it has two-score other features that make it really a Medical Encyclopedia. PERSONAL OPINIONS Howard A. Kelly, M. D., Professor of Gynecologic Surgery, Johns Hopkins University, Baltimore. " Dr. Dorland's dictionary is admirable. It is so well gotten up and of such conve- nient size. No errors have been found in my use of it." J. Collins Warren, M.D., LL.D., F.R.C.S. (Hon.) Professor of Surgery, Harvard Medical School. ''I regard it as a valuable aid to my medical literary work. It is very complete and of convenient size to handle comfortably. I use it in preference to any other." 8 DISEASES OF WOMEN. Webster's Diseases cf Women Diseases of Women. By J. Clarence Webster, M. D. (Edin.), F. R. C. P. E., Professor of Gynecology and Obstetrics in Rnsh Medical College. Octavo of 712 pages, with 372 illus- trations. Cloth, $7.00 net; Half Morocco, $8.50 net. FOR THE PRACTITIONER Dr. Webster has written this work especially for the general practitioner, discussing the clinical features of the subject in their widest relations to general practice rather than from the standpoint of specialism. The magni- ficent illustrations, three hundred and seventy-two in number, are nearly all original. Drawn by expert anatomic artists under Dr. Webster's direct super- vision, they portray the anatomy of the parts and the steps in the operations with rare clearness and exactness. Howard A. Kelly, M.D., Professor of Gynecologic Su rgery, Johns Hopkins University. " It is undoubtedly one of the best works which has been put on the market within recent years, showing from start to finish Dr. Webster's well-known thoroughness. The illustrations are also of the highest order." Webster's Obstetrics A Text=Book of Obstetrics. By J. Clarence Webster, M. D. (Edin.), Professor of Obstetrics and Gynecology in Rush Medical College. Octavo of 767 pages, illustrated. Cloth, $5.00 net; Half Morocco, $6.50 net. Medical Record, New York The author s remarks on asepsis and antisepsis are admirable, the chapter on eclamp- sia is full of good material, and ... the book can be cordially recommended as a safe guide." 9 SAUNDERS' BOOKS ON Kelly arid Cullen's Myomata of the Uterus Myomata of the Uterus. By Howard A. Kelly, M. D., Professor of Gynecologic Surgery at Johns Hopkins University; and Thomas S. Cullen, M. B., Associate in Gynecology at Johns Hopkins University. Large octavo of about 700 pages, with 388 original illustrations by August Horn and Hermann Becker. Cloth, $7.50 net; Half Morocco, $9.00 net. A MASTER WORK ILLUSTRATED BY AUGUST HORN AND HERMANN BECKER This monumental work, the fruit of over ten years of untiring labors, will remain for many years the last word upon the subject. Written by those men who have brought, step by step, the operative treatment of uterine myoma to such perfection that the mortality is now less than one per cent., it stands out as the record of greatest achievement of recent times. The illustrations have been made with wonderful accuracy in detail by Mr. August Horn and Mr. Hermann Becker, whose superb work is so well known that comment is unnecessary. For painstaking accuracy, for attention to every detail, and as an example of the practical results accruing from the associa- tion of the operating amphitheater with the pathologic laboratory, this work will stand as an enduring testimonial. Surgery, Gynecology, and Obstetrics " It must be considered as the most comprehensive work of the kind yet published. It will always be a mine of wealth to future students." New York Medical Journal " Within the covers of this monograph every form, size, variety, and complication of uterine fibroids is discussed. It is a splendid example of the rapid progress of American professional thought." Bulletin Medical and Chirurgical Faculty of Maryland " Few medical works in recent years have come to our notice so complete in detail, so well illustrated, so practical, and so far reaching in their teaching to general practitioner, specialist, and student alike." 10 G YNECOL OGY AND OBSTETRICS. Penrose's Diseases of Women Sixth Revised Edition A Text=Book of Diseases of Women. By Charles B. Penrose, M. D., Ph. D., formerly Professor of Gynecology in the University of Pennsylvania; Surgeon to the Gynecean Hos- pital, Philadelphia. Octavo volume of 550 pages, with 225 fine original illustrations. Cloth $3.75 net. ACCURATE Regularly every year a new edition of this excellent text-book is called for, and it appears to be in as great favor with physicians as with students. Indeed, this book has taken its place as the ideal work for the general prac- titioner. The author presents the best teaching of modern gynecology, un- trammeled by antiquated ideas and methods. In every case the most modern and progressive technique is adopted, and the main points are made clear by excellent illustrations. Howard A. Kelly, M.D., Projessor oj Gynecologic Surgery, Johns Hopkins University, Baltimore. " I shall value very highly the copy of Penrose's ' Diseases of Women ' received. I have already recommended it to my class as the best book." Cullen's Uterine Adenomyoma Uterine Adenomyoma. By Thomas S. Cullen, M. D., Asso- ciate Professor of Gynecology, Johns Hopkins University. Octavo of 275 pages, with original illustrations by Hermann Becker and August Horn. Cloth, $5.00 net. Cullen's Cancer of Uterus Cancer of the Uterus. By Thomas S. Cullen, M. B., Asso- ciate Professor of Gynecology, Johns Hopkins University. Large octavo of 693 pages, with over 300 colored and half-tone text-cuts and eleven lithographs. Cloth, $7.50 net; Half Morocco, $8.50 net. 11 SAUNDERS' BOOKS ON Dorland's Modern Obstetrics Modern Obstetrics : General and Operative. By W. A. Newman Dorland, A. M., M. D., Professor of Obstetrics at Loyola University, Chicago. Handsome octavo volume of 797 pages, with 201 illustrations. Cloth, $4.00 net. Second Edition, Revised and Greatly Enlarged In this edition the book has been entirely rewritten and very greatly enlarged. Among the new subjects introduced are the surgical treatment of puerperal sepsis, infant mortality, placental transmission of diseases, serum^ therapy of puerperal sepsis, etc. Journal of the American Medical Association " This work deserves commendation, and that it has received what it deserves at the hands of the profession is attested by the fact that a second edition is called for within such a short time. Especially deserving of praise is the chapter on puerperal sepsis." Davis' Obstetric and Gynecologic Nursing Obstetric and Gynecologic Nursing. By Edward P. Davis, A. M., M. D., Professor of Obstetrics in the Jefferson Medical College and Philadelphia Polyclinic; Obstetrician and Gynecologist, Philadelphia Hospital. i2mo of 480 pages, illus- trated. Buckram, $1.75 net. NEW (4th) EDITION This volume gives a very clear and accurate idea of the manner to meet the conditions arising during obstetric and gynecologic nursing. The third edition has been thoroughly revised. The Lancet, London " Not only nurses but even newly qualified medical men, would learn a great deal by a perusal of this book. It is written in a clear and pleasant style, and is a work we can recommend.* 12 GYNECOLOGY AND OBSTETRICS Garrigues* Diseases of Women Third Edition A Text-Book of Diseases of Women. By Henry J. Garrigues, A. M., M. D., Gynecologist to St. Mark's Hospital and to the German Dispensary, New York City. Handsome octavo, 756 pages, with 367 engravings and colored plates. Cloth, $4.50 net; Half Morocco, $6.00 net. Thad. A. Reamy, M. D., Professor of Gynecology, Medical College of Ohio. " One of the best text-books for students and practitioners which has been published in the English language; it is condensed, clear, and comprehensive. The profound learning and great clinical experience of the distinguished author find expression in this book." Macfarlane's Gynecology for Nurses (2d) Edition A Reference Hand-Book of Gynecology for Nurses. By Cath- arine Macfarlane, M. D., Gynecologist to the Woman's Hospital of Philadelphia. l6mo of 156 pages, with 70 illustrations. Flexible leather, $1.25 net. A. M. Seabrook, M. D., Woman's Medical College of Philadelphia. " It is a most admirable little book, covering in a concise but attractive way the sub- ject from the nurse's standpoint." American Text-Book of Gynecology Edition American Text-Book of Gynecology. Edited by J. M. Baldy, M. D. Imperial octavo of 718 pages, with 341 text-illustrations and 38 plates. Cloth, $6.00 net. American Text-Book of Obstetrics second Edition The American Text-Book of Obstetrics. In two volumes. Edited by Richard C. Norris, M. D. ; Art Editor, Robert L. Dick- inson, M. D. Two octavos of about 600 pages each ; nearly 900 illus- trations, including 49 colored and half-tone plates. Per volume : Cloth, $3.50 net. Matthew D. Mann, M. D., Professor of Obstetrics and Gynecology, University of Buffalo. " I like it exceedingly and have recommended the first volume as a text-book. It is certainly a most excellent work. I know of none better." 13 SA UNDE Ji S' BOOKS ON Schaffer and Webster's Operative Gynecology Atlas and Epitome of Operative Gynecology. By Dr. O. Schaffer, of Heidelberg. Edited, with additions, by J. Clarence Webster, M. D. (Edin.), F. R. C. P. E., Professor of Obstetrics and Gynecology in Rush Medical College, in affili- ation with the University of Chicago. 42 colored lithographic plates, many text-cuts, a number in colors, and 138 pages of text. In Saunders' Hand-Atlas Series. Cloth, $3.00 net. Much patient endeavor has been expended by the author, the artist, and the lithographer in the preparation of the plates for this Atlas. They are based on hundreds of photographs taken from nature, and illustrate most faithfully the various surgical situations. Dr. Schaffer has made a specialty of demon- strating by illustrations. Medical Record, New York "The volume should prove most helpful to students and others in grasping details usually to be acquired only in the amphitheater itself." De Lee's Obstetrics for Nurses Obstetrics for Nurses. By Joseph B. De Lee, M. D., Professor of Obstetrics in the Northwestern University Medical School, Chicago; Lecturer in the Nurses' Training Schools of Mercy, Wesley, Provident, Cook County, and Chicago Lying-In Hospitals. i2mo of 508 pages, fully illustrated. Cloth, $2.50 net. NEW (4th) EDITION While Dr. DeLee has written his work especially for nurses, the practi- tioner will also find it useful and instructive, since the duties of a nurse often devolve upon him in the early years of his practice. The illustrations are nearly all original and represent photographs taken from actual scenes. The text is the result of the author's many years' experience in lecturing to the nurses of five different training schools. J. Clifton Edgar, M. D<, Professor of Obstetrics and Clinical Midwifery, Cornell University, New York. " It is far and away the best that has come to my notice, a,nd I shall take great pleasure in recommending it to my nurses, and students as well." 14 GYNECOLOGY AND OBSTETRICS. Schaffer arid Edgar'y Labor and Operative Obstetrics Atlas and Epitome of Labor and Operative Obstetrics. By Dr. 0. Schaffer, of Heidelberg. From the Fifth Revised and Enlarged German Edition. Edited, with additions, by J. Clifton Edgar, M. D., Professor of Obstetrics and Clinical Mid- wifery, Cornell University Medical School, New York. With 14 lithographic plates in colors, 139 other illustrations, and in pages of text. Cloth, $2.00 net. In Saunders' Hand-Atlas Series. This book presents the act of parturition and the various obstetric opera- tions in a series of easily understood illustrations, accompanied by a text treating the subject from a practical standpoint. American Medicine " The method of presenting- obstetric operations is admirable. The drawings, repre- senting original work, have the commendable merit of illustrating instead of confusing." Schaffer Edgar'y* Obstetric Diagnosis and Treatment Atlas and Epitome of Obstetric Diagnosis and Treat= ment. By Dr. O. Schaffer, of Heidelberg. From the Second Revised German Edition. Edited, with additions, by J. Clif- ton Edgar, M. D., Professor of Obstetrics and Clinical Mid- wifery, Cornell University Medical School, N.Y. With 122 colored figures on 56 plates, 38 text-cuts, and 315 pages of text. Cloth, $3.00 net. In Saunders' Hand-Atlas Series. This book treats particularly of obstetric operations, and, besides the wealth of beautiful lithographic illustrations, contains an extensive text of great value. This text deals with the practical, clinical side of the subject. New York Medical Journal " The illustrations are admirably executed, as they are in all of these atlases, and the text can safely be commended, not only as elucidatory of the plates, but as expounding the scientific midwifery of to-day." 15 SAUNDERS' BOOKS ON GYNECOLOGY AND OBSTETRICS. American Pocket Dictionary „ ,Oi.. __ New (8th) Edition The American Pocket Medical Dictionary. Edited by W. A. Newman Dorland, A. M., M.D. With 677 pages. Full leather, limp, with gold edges, $1.00 net; with patent thumb index, $1.25 net. James W. Holland, M. D., Professor of Chemistry and Toxicology, at the Jefferson Medical College, Philadelphia. " I am struck at once with admiration at the compact size and attractive exterior, I can recommend it to our students without reserve." Cragin's Gynecology seventh Edition Essentials of Gynecology. By Edwin B. Cragin, M. D., Pro- fessor of Obstetrics, College of Physicians and Surgeons, New York. Crown octavo, 240 pages, 62 illustrations. Cloth, $1.00 net. In Saunders' Question-Compend Series. Galbraith's Four Epochs of Woman's Life Edition The Four Epochs of Woman's Life: A Study in Hygiene. Maidenhood, Marriage, Maternity, Menopause. By Anna M. Gal- braith, M. D. With an Introductory Note by John H. Musser, M. D., University of Pennsylvania. I2mo of 247 pages. Cloth, $1.50 net. Schaffer and Norris' Gynecology Saunders' Atlases Atlas and Epitome of Gynecology. By Dr. O. Schaffer, of Heidelberg. Edited, with additions, by Richard C. Norris, A. M., M. D., Assistant Professor of Obstetrics, University of Pennsylvania. 207 colored illustrations on 90 plates, 65 text-cuts, and 272 pages of text. Cloth, $3.50 net. Ashton's Obstetrics Seventh Edition Essentials of Obstetrics. By W. Easterly Ashton, M. D., Pro- fessor of Gynecology in the Medico-Chirurgical College, Philadelphia. Crown octavo, 252 pages, 109 illustrations. Cloth, $1.00 net. In Saunders' Question-Compend Series. Southern Practitioner "An excellent little volume, containing correct and practical knowledge. An admir- able compend, and the best condensation we have seen." Barton and Wells' Medical Thesaurus A Thesaurus of Medical Words and Phrases. By V ilfred M. Barton, M. D., Assistant to Professor of Materia Medica and Thera- peutics, Georgetown University, Washington, D. C. ; and Walter A. Wells, M. D., Demonstrator of Laryngology, Georgetown University, Washington, D. C. I2mo of 534 pages. Flexible leather, $2.50 net; with thumb index, $3.00 net. 16