Lectures of Rush copied by F. Bache [illegible]      D  E  F  G Franklin Bache Bache Vol. 2nd Vol. 2nd  H  1 The Institutes of medicine are only useful in their application, as a help to the practice of Physic; the Institutes are a part of an arch, which cannot be supported, unless the whole arch be perfect. It has been said, that the practice of Physic is not so certain a science as Chemistry, Anatomy or Midwifery. Formerly we did not know the use of some parts of the human body, now perfectly understood; but this does not prove anatomy to be an uncertain, but an imperfect science; neither should you confound the imperfection of the Practice of Physic with its uncertainty. It has also be said that the practice of Physic is stationary; but this is not true, for according to the population, the deaths 21 years ago, were half again more numerous than at present. That branch of medicine, which treats of [cross out] remedies, is called by the school men. Therapeutics I refer you to Dr Barton for an exact account of the doses of medicines; I shall only notice the principal divisions of the Materia Medica; Make till you what tools to work with; I shall have but few medicines from my belief in the unity of disease. I shall give you some rules for the discovery of diseases, 2. We must attend to the season of the year 3. We must never loose sight of the laws of epidemics thus Diseases &c. (in other side A) (2) which will be partly a repetition. 1. The same disease in cold or warm countries may require opposite remedies - 2. And even in the same latitude, the same disease will require different remedies, according to the proximity of seas or rivers. The bilious fever is milder according as we recede from the sea. We are like the British, as to our aliments, dress, and our buildings; and if our imitation stopped here, no harm would be done; but we follow their practice of Physic: you should all vow to be independent of British books and universities; even in our practical illusions, we go to great Britain for Similies; thus we hear persons speaking of music like the nightingale, or skipping like a lump lighter, although they [cross out] have never [cross out] heard the one or seen the other. We must recollect that we are not in the moist climate of great Britain, but in a warmer and a colder climate. We are under the necessity of altering our remedies for the same disease, in conformity to the variation of the climate, thus diseases which will yield to bleeding one year, will not bear the lancet the next. By this mode of practice, you will be blamed for instability, but never yield to prejudice, the world will at last do your justice; that these changes may take place in disease, Webster and Dr Haen vouch for, and Dr 4. Recollect that all diseases take on the appearance of the prevailing epidemic - thus &c. (in other side) A 3(3) Sydenham bore testimony to them in a variety of diseases, 4 this Sydenham remarks [cross out] that air intermittent fever, which put on a comatose appearance, [cross out] was cured by [cross out] [cross out] remedies [cross out] necessary for intermittents 6. natural habits should be studied, as they sometimes influence the forms of diseases; thus the natives of cold climates fall victims to the yellow fever, when going to the West Indies, while the old inhabitants are not affected by it; in Barbadoes the legs generally swell in an intermittent fever; thus also imigrant Irishmen require much more bleeding in an intermittent fever, before the bark will take effect than a native American; this was a remark of the late Dr Reynolds. In attending the sick of armies or navies, compond of a mixture of different nations, it is very useful to know this rule. national habits influence not only the force of diseases, but also the [cross out] operation of remedies; thus the Laplanders drink a large portion of ardent spirits, without detriment, and an Egyptian will require a large Cathartic [cross out] to purge him; it is the same case with the European in Calcutta, according to Dr Hunter; this remark applies also to the Tonic medicines, for it requires twice as much bark than is commonly used to cure an intermittent of the West Indies 7. you should also enquire into the government, 8: The rank in life has great influence 9. The occupation should be attended to - 11. Some persons have certain peculiarities of constitution; these should be attended to; they are called idiosyncrasies - A As Consumption Palsy hemorrhagy, piles &c. B In fact the disease will often appear to yield to any other than the usual mode of cure - (4) government, religion, and employment or profession of your patient, 10 but above all discover the predisposition; they are the following; The arterial, hepatic, nervous, muscular, cephalic phrenetic, alimentary lymphatic, and cutaneous - The bad effects of not attending to the predisposition is illustrated by the fable of the wax and brick; and of the Ass and Mule with their bags of cotton and salt - "What is one man's meat is another man's poison", or in the other words Remedies which will cure some will kill others. You should be acquainted [cross out] with the chronic diseases of your patients, 12 as also, their common habits; thus Rum would do a man accustomed to drink that liquor, more good, in Typhus fever, than wine. 13 You should also inquire into the hereditary diseases of your patients, and look back even beyond the preceding generation; gout and Madness often miss one generation, and appear in the next; we should attend to fetial diseases, A and become acquainted with the habitual remedies of your patients, thus if a man have been often relieved in a certain disease by bleeding, he will require more of it the next attack, to produce a cure; B the age of our patient should be attended to, thus vomits are safer remedies for children than adults from A And they return cephalic diseases with more certainty - B. together they have the disease of pregnancy - (5) from their being no danger of rupture, or breaking a blood vessel; and blisters behind the ears, are less dangerous for children than [cross out] old people; A calomel and bleeding can be borne by children, during dentition, Consumption is often cured under Puberty, as also children will recover, after having the black vomit, of the yellow fever, and of Epilepsy, but an adult, [cross out] rarely The sexes have an influence on diseases; in diseases of women, inquire into the state of the catamenia, whether excessive, deficient or stopped, B in the diseases of men, assertain the following particulars; to whether he makes use of tobacco or Secret drams, more especially of his use of tobacco in chronic diseases; interrogate him also, concerning what he eats; discover whether the disease arise from Love, Envy, or mortified Pride; this information, if it cannot be obtained from his friends, seek it of his enemies. I had a patient from Barbados with Gout; he told me he was very temperate; I asked him what he called temperate? why, said he, one bottle of wine, when at home, and three when abroad; how often abroad? twice a week was his answer; he went back to Barbados and died a martyr to his temperance!! We should never loose night of the remote cause, in our enquiries for it we should look 4 or 5 months back; for "Causa sublata tollitur effectis" not always true - (6) the more violent the remote cause, the more violent the disease; the remote cause has lurked 3 or 4 months in the system, before the exciting cause has [cross out] roused it into disease. Of Diseases said to be incurable Are there any incurable disease? Lord Rames, says, no; in the womb of time, in all probability, there are cures for all diseases; thus Syphilis, before the use of Mercury, was as fatal as Cancer is now; intermittents were formerly uniformly fatal; to say any disease is incurable, is as Lord Bacon says, establishing [cross out] Ignorance by law: you should not decline taking a patient, because you think his disease incurable, although Hippocrates and Celsus advise otherwise Of Diseases, which it is unsafe to cure. Some diseases should not be cured, 1st such as the sores behind the ears of children, without substituting a Diarrhea; 2: Bleeding piles in old people, or in persons having diseases in the head. 3. Gout should be kept in the limbs, when it keeps off melancholy nausea and bowel complaints; intermittent fever should not be cured if it succeed mania and vertigo, headach, Palsy or fear of the recurrence of the original diseases; upon this principle, a Physician of our hospital, Dr Thos Bond, was in the habit The cure of sore legs has produced death in old people a diarrhea should be cautiously restrained when it succeeds cobi, headach, or anamia. The Tupis purlis should not be cured; it is a laboratory pumping of the mucus which naturally collects in their tracheas - (7) of sending some of the maniacs every year to the swamps of Gloscester County, to bring on the intermittent fever; old ones should not be cured in old people; rheumatism should not be cured in Pulmonary consumption or mania, nor Gonnorhea benigna in an intermittent fever; habitual dispose - to sweat should not be restrained, the itch should not be cured in a hypochondriacal predisposition, nor gout or a rheumatic pain in the head when it keeps off Mania. Pains are very often useful; they sometimes keep as alive; Dr Sydenham says, the pain of the gout has keep many persons alive; and I should, suppose in the ear in which a predisposition to Cattarrh was cured by leaving off thick wooling stockins, that the pain prove from the cold feet kept off the catarrh - Of Specific Remedies are these any specific remedies? Dr Sydenham and Dr Boyle say yes; but the unity of disease cuts the sinews of this opinion: it is to be lamented that the idea of specifics did not die with the belief in Morbific matter; to be sure Mercury seems to be a specific in the venereal disease; but here it acts mechanically by mixing with the virus, and only upon one part: but although  (8) I do not believe in specific medicines, yet I believe in specific stimulants, but the kind of [illegible] stimulus, is the same as that in any other part of the body - Of the Operation of Nature, in Diseases - How far can nature cure diseases? this power got the name of the his Medicatrix naturæ; it was called by Stahl, the "anima medica" from its supposed intelligence: Cicaro justly says, "never was there an opinion however absurd, which was not embrassed by some Men," the belief in the no great power of nature, I have held long; the seeds of it were seen as early as 1772, as will be seen in an oration I delivered before the philosophical society; nature I consider is nothing but Physical necessity: what does nature do? 1st in hæmorrhagy she does very little; 2 what does she in a yellow fever or a typhus or a tetanus, she would not cure one in an hundred. 3. but we will complain of nature upon another score, she is sometimes mischievous, or in making too much blood after an amputation. 4. sometimes she is inert as in atomic gout; sometimes she alarms the system with much pain, when there is but little danger as in the Stone in the bladder; in other diseases we have not sufficient pain to warn us of A Scirrhus and aneurism B. Inverts the motion of the stomach and bowels - C and finally destroys life in a violent and general convulsion - (9) our danger, as in consumption A [cross out]; in these ideas, I am supported by many great men who have declared their opinions lately; Dr Willis says, speaking of the Plague, that so far from leaving the diseases to nature, we must fight with her, with the medicines of art: Dr Pringle says, that nature was unable to cure, or if she did, it was but imperfectly, certain diseases of the poor people: Dr Moseley says we must take the disease out of the hands of nature. Thus, if I would not reject nature altogether, I should trust her in very few diseases: besides, admitting that she may sometimes cure diseases, can there be any objections to our helping nature, and rendering the cure more shady Where is the analogy in the good tending of bleeding in Pleurisy, and opium in Dysentary, to the direction of nature, and who does not use these medicines in those diseases; let us inquire what nature does in a bilious fever; she overhelms the whole frame with blood, B she tears the blood vessels, [cross out] dissolves [cross out] the blood, [cross out] deluges the body with unprofitable sweats. C but still I admit that she has some power in slight diseases, but, as weak medicines, if trusted to alone to cure violent diseases, will do no good or harm; nature is much like the moral faculty, she has to be regulated otherwise she will go wrong; thus, when you  (10) are called to a patient with a violent disease, I would advise you to treat nature as a noisy cat or dog, turn her out of doors, and shut the door upon her. This great idea of the power of nature in the cure of diseases, was taken from her operations in the healthy state, which will by no means hold good in disease which is a state in which one part will be prostrated, another overacting, one part cold, another hot, the blood beats upon the brain, convulsions ensue and death closes the scene; such gentlemen are the effects of disordered and debilitated nature He strengthens his ideas by the analogy of moral good and evil - The advantages to be derived from observing the tendency of nature We should take advantage of the tendency of nature to this or that part, in throwing off the disease; sometimes in a fever she will attempt to relieve herself by the bowels; take the hint and cure with purges; if hemorrhagy take place, bleed; Dr Sydenham used purges with success in a fever in London, from observing that nature had a tendency to throw off the disease is that A for aliments and drinks, air and exercise (11) way. In infancy and childhood, nature throws off disease by sores behind the ears; there let us deplete - In youth, to the lungs; let us apply blisters to the breast; in old age the tendency is to the bowels; let us therefore cure old people by purges; nature may be compared to a finger part, which points out the road, but does not move a step herself; but however safe we may be in a weak disease, in choosing the part point in out by nature as our only emunctory; [cross out] let us beware of an equal confidence in more violent diseases, as this would be like opening but one door of a church, in case of fire, for the people to escape at, when it would have been easy to have saved all the people by throwing open all the door. Nature is either too quick or too slow, too anticipating or too procrastinating, too partial or too general; she is too quick in [cross out] Yellow fever, too slow in Typhus; to anticipating in sweating on the first day of a disease, too procrastinating, in the sweat at death - In this discussion, it will be expedient to inquire how far the longings of our patients A are to be gratified; I admit that in some instances this indulgence has been the means of a cure; thus a draught of cold water has produced a sweat which has saved life, when it is probable; that A As oils, acids, diluting and demulcent drinks - (12) if the system had been a little more or less excited it would have produced death; also a piece of beef stake, or ham, has given the system, in some rare instances, in Typhus fever, a tilt in favour of life; cold air has acted in the same way, by some happy chance. The predisposition should be watched narrowly also the disease itself, and lastly the symptoms - Of the Choice of Medicines. 1. Medicines are generally contrary to our tastes and appetites; these quantities have been given them, to prevent us from using them as aliments; they may be considered as so many slow poisons of different strengths, from arsenic and opium down to Nitre and Chamomile tea - 2. Medicines may be agreeable, and have a tendency to dissolve acrimony A 3. Those which are agreeable, but act by raising and stimulating the system, as common aliments and drinks 4. Those which are both agreeable and disagreeable; as cold and cool air; hot, cold, and cool water, and ice, and exercise and labour - Let us have but few Medicines.  (13) 1. Let us have some with energetic qualities, as Mercury, purges, vomits &c - 2. Then a few 3. Then a few bitters, for bitters all act differently He compares the practice of giving few medicines in combination, to the combination of the remain bitters, so as to form any word, whereas, the contrary practice he compares to the Chinese alphabet, which has a [cross out] different character for every word Of the Mixture of Medicines Should we give Medicines alone or in combination? I say, in both ways; the bark, opium, ammonia Rhubarb act very well by themselves, yet it is necessary often to combine them; this Dr cured a cancer by Corrosive Sublimate and Hemlock, [cross out] which had resisted the power of Hemlock alone - Jalap is improved by combination with cream of Tartar; and Senna, when combined with Manna or brown  (14) sugar; Dr Fourdyce tells us squills are improved by combination with gum ammoniac, and sulphatic of Zinc when mixed with Ipecacuanha; alum is rendered a bitter astringent by combination with red Roses; and black pepper and Capsicum never heat the stomach when combined - Of Consultations. They should be required, 1. In all doubtful cases - 2. In all dangerous, but not doubtful cases - 3. In tedious cases - 4. In desperate cases - 5. In cases in which the patient is a friend, his solicitude will derange his judgement. - never have a consultation with a Physician who [cross out] practices [cross out] upon different principles from yourself; it is like yoking an ox and an Ass. together; persons who will consult under such circumstances, are like merchants, labouring for money, and not for the life of the patient - of the preparation of Medicines - 1. The same medicine will agree or disagree, according  (15) to the different forms in which it is prepared; thus bark is a different medicine in Zinc, decoction [cross out] extract [cross out] or substance; some persons can take opium, but not Laudanum - 2. Other medicines cannot be taken, because they formerly disagreed; this arises from association; hence a Lady could not take Calomel when she knew it - 3. We should not prescribe medicines, shocking to delicacy or which are expensive; under the former head we may mention. Cow's dung, called album græcum; cow's Urine, called flower water; as expensive prescriptions we may enumerate, wine and opium baths happily for as the best medicines are the cheapest - In preparing medicines for the sick, we should pay attention to the label, the manner of writing it; to spelling correctly, and making the proper abbreviations of the words - pullar medicina, aliquado, oftima medicina"; hence, sometimes a patient has recovered [cross out] after having been given over by the Physicians - You may persuade your patient to take his medicines by explaining their intended effect. - A There is now and then a recovery after the occurrence of every mortal symptom - B Male nurses are the best, since they do not despair as soon as female - C This takes place when the force of the [cross out] remote cause is such as to depress the system below the point of reaction (16) It is well for Physicians to sit up with their patients in dangerous cases; by this practice they will learn some things; they will discover the seat of pain in sleep; the state of the mouth and eyes may be seen with more advantage in sleep never give a patient over in an acute disease; A we must dispute every inch of ground with the disease: in chronic diseases, we should be very prudent in giving our opinion; we should take patients in our own hands, and in some instances rescue them from their relations and female nurses; by [cross out] attending to this rule, many are matched from the grave B The Grades of Excitements 1. Preternatural excitement, but regular. 2. Debility, from action or abstraction. 3. Depression - 4. Disease 5. Oppression C 6. Prostration; which forbids depletion, stimulants alone, will raise the system - 7. Disorder - 8. Subsequent debility, as the durable consequence A. and stimulants proportional to the excitability; of the debility be more chronic, then stronger stimulants may be used - B. The reins and implores as to attack disease in its forming state - (13) of cured disease or disorder 1. Elevated excitement is known by sprightliness and wakefulness; the remedy is a purge, or the loss of a few oz of Blood, or low diet - 2. Debility from abstraction or action is cured by rest; A obvious debility generally preceeds general diseases B 3. Depression is indicated by sighing, fainting, this is cured by gentle laxatives - 4. For the cure of disease we have either stimulants or Sedatives, the two grand divisions of the Materia Medica. - In all diseases, there is unequable excitement. Here he enumerates to different combinations of excitement and excitability - The following circumstances should be inquired into, in determining the state of the excitement and excitability - 1. The recovery of the disease,; if recent, we may always presume on a good stock of excitability - 2. From experience; similar diseases have generally equal degrees of excitement and excitability; A In the muscles and the observe of both in the bowels - B This has the effect of producing pain in the diseased part - (18) in Tetanus, there is great excitement, but little excitability A 3. The grade and seat of the excitement should be determined by remedies; Dr Sydenham has unfolded, a doubtful chronic disease, by exercise and a few glasses of wine. B 4. There is not much excitability left in tedious diseases; in the camp and Jail fever, wine, bark and Spirit are the only safe remedies; for we may be certain that the excitability is worn down, and consequently may safety begin with stimulants - By stimulants I mean those remedies, which increase life wherever it is wanting, and equalizes the excitement. Those remedies which increase the quantity of life and tone are called Tonics - By sedatives I mean those remedies, which blunt sensation, and diminish motion; they act in 3 ways 1 By the abstraction of stimuli, as cold and darkness, bring the abstraction of the stimuli of heat and light, 2. Such as first appear to be stimulants, but are sedatives in effect; these are [cross out] cathartics Cold air? has been found useful in convulsions and Hysteria, and all diseases consisting in morbid excitement in the muscles and nerves - A as well as from labour, I shall hereafter speak of the efficacy of this remedy and the time at which it is to be used - cathartics, emetics, sialagogues, or errhines; these all produce indirect debility - 3rd Those which act insensibly, as Digitalis, Sugar of Lead &c - There are called direct sedatives - Direct Sedatives. 1. The first direct Sedatives bleeding; we shall speak of it hereafter in fevers - 2. Cold is a direct sedative; Dr Sydenham introduced cold air in the cure of fever, under this head is included cold air, water, and ice - 3. Fear acts as a direct sedative, it equalizes excitement, hence it [cross out] will cure hiccough by debilitating the diaphram - 4. Rest this includes absence from business and study. A - 5. Abstinence as a relative term; it is either a seduction of our usual food in quantity, as it is necessary to do with old people, who cannot have the quality altered, or it is an abstraction of quality, when it is necessary to have a certain quantum of distention. More nourishment is afforded to the body by fluids than A and prevent eating much - B as carrots parsnips and beets - C Reasons for believing Hippocrates' maxim 1. By feeding a diseased body, by increasing the quantum of blood, or risk disorganization and death - 2. In a diseased body there is less occasion for the stimulus of food, as the stimulus of disease is a substitute - C. in the stomach which robs the other parts of the body of their necessary excitement to resist the disease; in order to shew the good effects of dieting in keeping off disease I mention the following case - Dr Gregory &c. (20) an equal quantity of solid food; elements may be arranged in the following order, according to their grades of nourishment 1st Fresh full grown meat; 2nd the fat of such meat 3. Poultry. 4th Salt Meat and salted Fish; this last I consider as low diet, for the stimulus of the salt is but transient!!!!; after salt meat and fish, I place 5 eggs, then 6 scale fish, then 7 shell fish, after that 8 Milk, next the 9 Saccharine vegetables, B then the oily vegetables; and lastly gum Arabic; but there are morbid states of the system in which it will be necessary to abstract aliment altogether - Hippocrates said, "the more you nourish a diseased body, the more you injure it" - C 3. Because By digestion, [cross out] the diseased body has an [cross out] accumulation of excitement; C Dr Gregory and his officers were cured [cross out] of a predisposition to disease when in prison, by having to live on rice and water; upon being released, they found all their brother officers, [cross out] dead, who had lived at Madras A. Pude says that those animals which die of famine have the internal surface of their intestines very clean and white; what would be the effect of fasting in clearing the bowels filled with bile - A. It acts more certainly if attended with taciturnity- (21) All these things prove the necessity of a diminution of aliment in quantity and quality in disease. Indians abstain from food 3 or 4 days before battle, in order to render their wounds less fatal; not only abstinence, but fasting are useful, in all cases in which patients are above far; it has cured Asthma A Wild Beasts are tamed by fasting; [cross out] might we not tame Mad Men in the same way? Adults can bear fasting better than young persons; Sedentary better than labouring persons; in winter it is easier borne than in Summer, according to Celsus; but, says Celsus, if our patients will eat, give them an emetic immediately afterwards; Butchers tell us that meat is less liable to [cross out] putrefy of those animals which are fasted before being killed - 6. Darkness is a sedative - 7. Silence is a Sedative? 8. Reduced air is a sedative; it acts by reducing the stimulus of oxygen upon the lungs - let us now speak of those medicines which lessen action in directly, by first producing a stimulating effect A Nitrous oxide upon the mind - B Diuretics were to act in this way - (22) Of Indirect Sedatives 1. Some Medicines have a specific action; thus Rhubarb affects the bowels, but has no action upon the blood; bark is exactly the reverse; carbonic acid gas is a posion in the lungs but a cordial in the Stomach; Jalap acts upon the bowels, garlic and Assafœtida on the nerves, A and oil of amber on the muscles, while opium and wine act upon all these systems - 2. Certain medicines act on all the systems [cross out] through the Medium of the [cross out] nose, skin, rectum, mouth or stomach, but as the stomach has the greatest range of sympathy, it will be acted upon with the greatest advantage - We may make medicines act on different systems by combination; then Aloes and Assafœtida will act upon the bowels and nerves, and nitre acts upon the Stomach, blood vessels and renal glands. 3. Some remedies act by getting into the blood B 4. Certain Substances go through the body without doing good nor harm as madder !!! - 5. Some remedies act chiefly on the sensibility mustard plasters act upon the sensibilities, and if they produce any effect upon the pulse, it is indirectly, by means of pain - 1. They discharge matters from the stomach; they invest the peristaltic motion; they act on the Kidnies open the pores, relax spasm - (23) others on the irritability; thus Camphor acts, chiefly upon the sensibility; Digitalis certainly chiefly on the excitability, and opium and Bark on both; Tobacco, when applied to the skin does not affect it but produces nausea, Mustard, irritability of the skin but no effect on the stomach - Among the indirect sedatives I place Emetics I Emetics - These Emetics said by some to be unnatural remedies; but this cannot be, does not nuture but the dogs to vomit themselves? Emetics may be either prompt lenient or forcible vomiting may also be brought on by a rotatory motion and Association - 1 Under the head if prompt emetics may be enumerated, irritation of the fauces with a feather; white vitriol, large draughts of water previously made nauseous, rotation and association - 2. Under the head of Lenient emetics may be enumerated Tobacco, Chamomile Squalls, Ipecacuanha, and like warm water. - 3. Under the head of forcible emetics may be I was in the habit during the war of carrying a number of emetics in my pocket and giving them to every solider that complained of headach and sickness of stomach, which symptoms indicated the coming on of the camp fever - (24) enumerated Tartar emetic, glass of antimony, antimonial wine, Turpeth mineral, blue and green vitriol, and water, to act by its quantity. Emetics are required in the following cases 1. The forcible and prompt emetics are required when poison either by accident or design has gotten into the stomach - 2. They are required when the stomach is loaded with bile or mucus, or indigestible substances, here lenient. 3. They are required in the first stage of Dyspepsia, if attended with languor of the stomach; here the lenient [cross out] and forcible must be used - 4. They are indicated in Diarrhœa and in some cases of dysentery, from [cross out] counteracting the peristatic motion of the bowels - 5. The small pox is often prevented in its forming state by lenient or forcible emetics, also they are useful in the last stage of Typhoid fever Dr Huxon tells is they are safer than purges, I believe it, for I [cross out] never saw death produced by emetics, although A after bleeding has been used - B. They are suddenly useful sometimes in asthma, by relaxing the spasm of the trachea upon which it depends. 11. They are useful on opening the pores - (25) many patients have sunk under purging - 6. They are also useful in Catarrhs, pulmonary consumption, Cynanche Trachealis, and asthma; A here they soften the pulse and mitigate the cough B 7. They are good in the diseases of the trachea generally from the sympathy of that part with the stomach - 8 They are given in Hæmorrhagy - 9. They are useful in removing the torpor of the liver or spleen and in dropsies of the abdomen; the lenient or forcible must be used - 10. Dr Hunter tells us, he has resolved a venereal bubo by the action of emetics - 12. The lenient emetics will do good in slight pains in the head when arising from a foul stomach - 13 Emetics are safer remedies with children than grown persons; from their stomach's bony lined with mucus. Rules for the exhibition of emetics - 1. You should give dry vomit in pressing occasions, and in large doses - A or fullness and pain in the head. A In order to prevent spasm to the stomach - (26) 2. when the case is not very pressing, you should divide the dose to prevent danger - 3. In all cases of plethora, indicated by the pulse A and in fever, their use should be premised by bloodletting; it renders then more prompt, useful, and safe - 4. We should not give great quantities of water during the operation of Emetics; this custom is called, working off Emetics, but it weakens the action of the emetic upon the stomach unnecessarily; it arose from Dr Boerhaave's system of diseases, namely, that they arose from acridity - 5. you should always give a vomit in the morning; because nature points out that time as the most proper, especially if a dose of opium has been taken the night before - 6. you should never allow your patients to puke in a recumbent posture, A if the vomiting be too severe, give a few drops of Laudanum, or some chicken water, which last you may use very plentifully untill you have accomplished your end; if we find them safe, they must be repeated every day or two, otherwise they will do no good; hence the sickness produced at Sea is so beneficial - Formerly vomits were given to remove foreign matters Cathartics are to be used 2 when the stomach is filled with bile and when our patient will not take an emetic. 3. They are alike indicated when these matters are in the bowels - (27) matters only from the stomach, and hence only one emetic was [cross out] given in a disease, but now that we know that emetics are useful in many diseases, let us give them much oftener - [cross out] 1 Vomits [cross out] must not be given in congestions of the brain or lungs. [cross out] They [cross out] must not be given in inflammation of the stomach, when there is reason to apprehend the production of Spasm, nor in the advanced stage of Pregnancy, nor to those subject to Ruptures - 9. They [cross out] should not be given in [cross out] any case of low fever, but [cross out] in slow chronic fever, they may be given gr? - II Cathartics - A Cathartics are such medicines which have a tendency to empty the bowels; they act either by translating action- to, or originating [cross out] it in, the bowels; they may be divided into lenient active and drastic. - The lenient Cathartics are castor oil and sweet oil The active, such as aloes Rhubarb - Senna The drastic, such as Calomel Scamony, gamboge, Quicksliver, black Helebore, Bucks thorn, Jalap, and lastly fasting - 4. In the Torpor of the bowels which occurs in Hypochondriasis & colica pictonum the drastic are necessary. A When weakness does not forbid them. b- They are good in diarrhea when the pulse is not too low - B. As well as by discharging matters from the bowels - C. this proves the increased action of the absorbents - D This fact was observed by Dr Sydenham and confirmed by Sir John Pringle - (28) 5. In all febrile diseases in which pulse is above par; and in Dysentery, A the lenient and active purges are indicated - 8. The drastic purges are to be used, when the head is affected, or the pulse active; they are good in St Vitus' dance - 9. They are also indicative in all the diseases of the [cross out] liver and Spleen, and omentum - 10 Male action hemorrhagies, whether from the lungs bowels or Uterus the lenient purges must be used as well as in all cases of tonic or inflammatory dropsy; in this last case they act by increasing the action of the absorbents B x 11 In the stoppage of the hæmorrhoidal vessels, or piles, and in diseases of the skin, the lenient purges must be used - * Persons have been found to weigh more after taking a purge, from the absorption of moisture from the air, C Rules for the exhibition of Cathartics - 1. The drastic purges act better by being mixed with the lenient, D as Calomel and cream of Tartar, Jalap and cream of Tartar, calomel and Rhubarb A Hence they are improper in Typhus fever, where Dr Hamilton used them; I make our exception to this rule, as when we give them for their reclusive action - (29) Jalap and Rhubarb and Senna and Manna. 2. after having been purged for some time, a much less dose will act - 3. Liquid purges are to be preferred; they wash the bowels - 4. In long continued purging the Cathartic should be changed - 5. no solid food should be taken during the operation of a purge - 6. no watery aliment should be taken to work off a purge; you should not be contented until you had induced an artificial diarrhœa, for it is thus nature carries off any offensive matter from the Stomach - 7. Their action is increased by having fasted the day before - 8. They should be repeated every two or three days, but in a bilious fever they should be given every day They are forbidden - 1. When the patient is below par A even great slim is not to be removed, when attended with great debility; it is best removed by tonics -  (30) 2. They are forbidden in most of the diseases of the lungs. 3. They are forbidden in hemorrhagy from the bowels - 4. They are forbidden upon the accession of Colica Pictonum, for a reason to be mentioned hereafter - Horses have more irritable bowels than men. On the use of Clysters - 1. They are to be preferred when the stomach rejects purges; 2 They are to be used in obstructing matters in the rectum - 3 They are proper when a revulsion is wanted from the head, throat - lungs or stomach - 4. The are necessary when the kidnies, uterus, or bladder are pressed [cross out] by the contents of the bowels - 5. When we wish to pulsate costiveness of the lower bowels; the French are very fond of their use Clysters act by their quantity and quality 1. Quality, take from 1/2 pint to 3 gills of water, add a little Molasses or oil, with a little aloes - 2. Quantity; or a portion of simple water; it will often produce a stool - air and the smoke of tobacco have been used when a structure or intussusceptio [cross out] is suspected.  (31) But however severe your clyster may be, it only affects the lower bowels, just like that brush which is used to remove the soot from the liver part of [cross out] a chimney; it is calomel and Jalap alone which can sweep the chimney from top to bottom - III Diaphoretics - That these medicines act by depleting is evident, from our diminished weight after their use, this effect is often seen in Partitions who side in races; Dr Sydenham says that patients will feel stronger after sweating; this arises from pressure being taken off; it is often the same after purges for a similar reason - I. They act upon the skin immediately, as air oil, water, vapour, blankets, salt, sand, and clay. Dr Sydenham excited a sweat by blankets in the plague; they act by containing the heat of the body. 2 In Hats they sweat with hot air in cells; [cross out] they are called Indateria - Salt, sand, and Clay have been used, covering the patient with them except the head; Salt is best; when we wish to sweat the head, we must cover it with blankets, and throw over it the vapour of vinegar - A. It is used in slight indispositions. B. by cold air and cold water, they acting by &c. C. I explain this by the sympathy of continuity between the stomach and [cross out] skin - (32) Pediluvium. A It should be used for a half hour, and the patient put immediately into bed. [cross out] fomentations to be useful, Pringle tells us, should be used for [cross out] one hour - II Sometimes sweating is produced, B by reducing the capillaries to the sweating is point, [cross out] - III They may be obtained by cold suddenly after heat, as is the practice with the Indians - IV They may be obtained by exercise and rest [cross out] 1 [cross out] Some Diaphoretics act by exciting nausea in the stomach, C and whether the skin be above or below the sweating point they produce their effect, but neutral [cross out] Salt produce the effect without exciting nausea, as nitre - 2. Some act upon the blood vessels as well as stomach, as wine, opium, [cross out] vinegar serpentaria, Chamomile, Eupatorium, Centaury - 3. Some act by distinction as [cross out] water - 5. Purges may be enumerated under the head of Diaphoretics; and more especially the popular one of A. Hence the popularity of sweats in the fevers of Britain; which are of this kind - B Flannel should be worse - (33) 10 and 10 in yellow fever: a man in Edenburg was in the habit of curing himself of the venereal by copious sweating; in this case the sweating was so profuse, that the shirts of the person could not be washed without tearing, such was their brittleness Diaphoretics are to be used 1. In acrimony - 2. In mild fevers A - 3. In fevers having a tendency to relieve themselves in this way; also in the centrifugal diseases of gout and Rheumatism - Formerly sweating medicines were given in all diseases; from an idea that they arose from specific morbific matter; and at present they are persisted in, from a belief in Dr Collin's theory of Spasm of the Capillaries - When we wish to sweat ourselves we should go to bed, for we sweat more in 9 hours in bed, than 15 out of it; B the linen should be changed 4 or 5 times a day we must not attempt to sweat when the heat of the body is above 100 degrees, for if it does take place, it is either partial or injurious; in this state of a patient, A which have been impregnated with sweat should be frequently changed - Here I make two remarks - 1 Nature &c (in other side) B That Brutes never rest to them although they use both emetics and purges - A Dr Sydenham used to open the urinary passages in small part in this way - (34) patient, I ordered the use of the sponge; the sweat followed uniformly the track of the sponge. 7. It is supposed necessary to give diluting drinks to sustain the patient; they do no good, unless they blunt acrimony, or act by distention - 8. The linen, including sheets and blankets. A [cross out] otherwise the sweat will putrify in them - 9. Great care should be taken to prevent [cross out] excessive sweating, it is a mortal symtom - in typhus fever - 1 nature seldom brings in sweats, except in violent states of the System, that is, in the forming state of fevers, and at death from all diseases B IV Diuretics Diuretics are medicines which increase the flow of urine - They are 1. External; as cold air, and cold water; A we are all acquainted with the effect of [cross out] cold water, by going into bath early in the spring; the same effect will be produced by placing the hand in cold water in sleep; this is a boarding school trick; warm water will produce the same effect. A Different preparations of iron and the vegetable acids - (35) 2. Going up and down stairs has a diuretic effect 3. Certain noises such a the pouring of a tea pot; Dr Whytt tells us of a certain man, who always had a inclination to make water when he heard the sound of the bag pipe - 4. Fear, I have published a striking instance of of the effects of fear as well as abstinence in dropsy, in my Inquires - 5. Such substances as act directly on the kidnies, as Carrots, water Melons &c Parsley - 6 Such as act indirectly upon the kidnies, as Squills Digitalis, Turpentine, onions opium, fixed alkalies and neutral salts &c &c A Diuretics should be given in some cases, to act only as evacuants; [cross out] The premonitory sign of the plague of Bussora [cross out] was a great discharge of urine; the same thing, in some instances I noticed in the yellow fevers - 1. Diuretics of a mild kind should be given in the forming state of dropsy - 3. They are indicated in obstructions of the Ureters, either from engorgement of the kidnies, or Spasm of the urethra or the neck of the bladder - They are also indicated In pneumonies, catarrhs asthma and pulmonary consumption; thus should be lenient or stimulating, according to the greater or less morbid action of the lungs - A Iron is good to raise the uterus to the emenagogue point; when the system is above this point, I always depend upon depletion and afterwards exercise - (36) 4. They are forbidden in debility either from action or abstraction; hence in atomic dropsy they are forbidden; for here tapping very often kills; in this same way would diuretics be fatal - V Expectorants - Matter is of 3 kinds, Pus, Mucus, and Phlegm, the great use of the lancet has in a great measure obviated the necessity of expectorants - 3. Some expectorants act directly upon the lungs such as volatile alkali, Tartar, oil of amber; the vapour of these substances ascend from the stomach and is taken up by the bronchial vessels; to this class may be referred, to boars tea, barley water, liquorice, the smoke of Tar, and a combination of Tar and wax, thrown upon hot coals - VI Emenagogues - no medicines act specifically upon the Uterus, Madder is said to have such an action; but experience does not sanction this belief, for it has not been remarked in the human female, but in Mares only. As emenagogues, Aloes, Gum Guaiac; Seneka &c &c as also Matrimony, exercise &c &c A may be used - A It acts further on the parts near the glands - B. Even in adult life, nature relieves herself by the emunctory of the mouth. (37) VII Sialagogues - They have been divided into those which act upon particular glands and parts, as tobacco radix Spirethic; and those which act upon the whole system of glands as Mercury and Saccharum Saturm and arsenic. Calomel acts in two ways, by revulsion and depletion, A a Salivation is an unpopular remedy; it is said to be an unnatural remedy, but this is not true, for we see, when children have sore mouths, that nature puts in this mode of action; this sometimes happens in Cynanche Trachealis., B further, Dr Sydenham makes mention of a malignant fever, cured by a spontaneous Salivation, and a spontaneous salivation generally attends those cases of small pox which terminate fatally: a spontaneous salivation has cured Gout and Dysentery, the former case was under my care, the latter, under the late Dr Clarkson; in madness, we see a constant action of the salivary glands; hence Maniacs have been called Spectatores; besides, a sore mouth in fever is universally considered as a favourable sign; [cross out] and why shall we not take this hint, and assist nature? A This I used in '95; it produced universal clamour. B. This I have on the authority of Dr. Chisholm - Cheyene gr? (38) we have to regret, that we cannot always produce a Salivation. It is rendered more certain; 1 By bleeding, if the pulse be tense- 2. By low diet; this acts as bleeding [cross out] they both prevent [cross out] a tendency to gangrene - 3. By Vomits; which act by awaking sensibility and the action of the absorbents of the stomach 4. By opium, this either prevents the mercury passing the bowels, or acts by raising the system to the salivating point, when [cross out] below it - 5 By Cold; this acts by bringing the system within the sphere of action of the Mercury A 6 Dr Porter of St. Croix, informed Dr Cheyme that An increased Salivation by Jalap; I have myself accellerated the action of mercury by combining it, with nitre - 7. By injecting mercurial ointment into the bowels; B 8. By varying the preparation, as to Corrosive Sublimate, or red precipitate, or Turpeth mineral - 9. By withdrawing the medicine for a few days or weeks - The above modes of accelerating a salivation must be used only when the system is above the salivating point; but when the system is below that point, the A And the armpits also; by mercurial locks - B. But lately an ingenious friend of mine explains it by the oxygen which the preparations of mercury contain - (39) system must be prepared by giving bark and other tonics; in these cases, it must always used as a revulsive, and not as a depleting remedy; mercury may be given to Maniacs by spreading it upon bread, and covering it with Butter - All these internal modes are accellerated by rubbing the skin with Mercurial ointment, A and the gums with Calomel; it is not by cutaneous absorption that the two last means have their effect, but by the absorption of the vapour by the lungs, never the reason the arm-pits are preferable from their proximity to those organs B Dr Spalding of Massachusetts has communicated a case in which a salivation took place 6 months after the exhibition of Mercury; we had an instance in our hospital. It is to be regretted we cannot produce a Salivation certainly; it failed 3 times out of 4 in the yellow fever - To obviate the effects of Mercury - 1 Purges are to be used, of which Sulphur is to be preferred - 2. Bleeding, if there be either great pain, a  (40) tense pulse or a tendency to Mortification. 3. Opium. 4. Blisters. 5 Washing the mouth with a solution of Borax [cross out] in a solution of Green Tea - 6. Washing the mouth and fauces internally and externally with cold water; this practice was formerly thought madness - Mercury is useful - 1. In Malignant fevers - 2. In Morbid determinations of the blood to either the brain, trachea, lungs, liver, or joints - 3. In Dysentery and Diarrhœa when obstinate. 4. In Dyspepsia, when it resists other remedies - 5. In obstinate Ulcers - 6. In the venereal disease; there, to do good the salivation must be complete!!!! - 7. In Hydrophobia; but the disease is generally too violent for the Mercury to affect a cure; in some [cross out] diseases it does harm if it salivates, and good, when it touches the mouth only; this is sometimes the case in visceral obstructions, and certain cutaneous affections - 8. and lastly, Mercury is useful in visceral obstructions, and in certain cutaneous diseases. A Happily for us it is not easy to make the mercury take affect here - (41) Mercury is forbidden. 1. During great action in the arteries 2. In the low state of the system, when depletion is improper; A 3. In children under the age of 6 years; for under this age the gums are so tender, as to be liable to take on gangrene - 4. In old persons, above 60 years of age; but there are two exceptions, namely, when all the teeth are sound and firm, and when they are all wanting; but in desperate cases, do not be afraid, for it is better, to run the risque of an uncertain gangrene in the jaws and the loss teeth, than lose our patient - It must be regretted that this remedy is loathsome, and often very painful; when we reflect, we loose our teeth and have a sore tongue, we are reminded of the punishment of those parts which ate the forbidden fruit, and are constantly sinning - VIII Errhines - Errhines are such substances as excite a discharge from the nose; they produce their effect generally by sneezing.  (42) Many diseases go off with a sneezing; under the head of Errhines, we have Tobacco, Turpeth Mineral, muzewort, white Hellebore; they are not to be used when the blood vessels are turgid; they are good remedies in Tooth ach, and ear ach - IX Blisters - At a time when Spanish flies were expensive, I made a more perfect and prompt Blister of equal parts of Cantharides and Mustard - 1. Blisters are indicated in congestions of the lungs, brain, & joints - 2. In diseases of moderate action - 3. In Sudden congestions; here boiling water should be used - They are forbidden. 1 In all fevers, above or below a certain point, called the blistering point; the proper state of the system is attended with the typhoid pulse - 2 They are forbidden in highly irritable people, and persons disposed to be affected by strangury - Rules for the use of Blisters - 1. They should not applied on the diseased part,  (43) but near it. 2. When the disease is deep-seated, it is no matter to what part they are applied, unless [cross out] it be emptied by contiguous or continuous sympathy - 3. They do most good when the disease is loosened 4 In Malignant fevers, when there is a tendency to destroy a virus, make use of blisters even before the system is at the blistering point, for the purpose of actuating morbid action from the virus; this may be considered as a kind of cutaneous Salivation. 5. In fevers in which there is a tendency to gangrene in the extremities, Blisters should applied to the thighs - 6. Blisters should be taken off, after having risen, or after giving unnecessary pains - 7. Blisters to the head never rise, but a serous matter oozes out. - 8. The application of 5 or 6 blisters at the same time is sometimes necessary - 9. They never discharge much, after the 1st or 2nd dressing -  (44) 10 If a blister be applied at the blistering point, Serum will be discharge alone; if above that point, a sore, or pus is produced, if below, an angry dry sore is produced which often turns to gangrene; so that if a blister first discharges Serum and afterwards pus, it is a good sign, since it indicates the system rising; but, on the other hand, should a Sanies follow, it is a bad sign - The importance of the application of blisters at a certain point, is exemplified by their effect in Dropsy; for when applied [cross out] at this point, they do extraordinary good, in evacuating the water; and extraordinary harm, if applied at any other time - X Issues - These are either Setons or perpetual blisters - Let it not be supposed that such inconsiderable discharges cannot cure disease; for a Sea Captain was cured of [cross out] Consumption by a gleet, as I formerly told you. They are indicative. 1. When a gradual discharge of redundant fluid A after the system becomes accustomed to them by habit; beware of suppressing them, without substituting some other drain - (45) is necessary, as in Consumption. - 2. They are indicated in local congestion in the head and other parts - 3. Also In Cutaneous eruptions in exposed parts, such as the hands and arms - Issues keep off Malignant fevers; those who have seen many plagues can tell when a person has that disease by a pain in his issue; there is also an acridity in the breath, of which the patient is unconscious - Perpetual Blisters - Are the best issues; they are less offensive to the prejudices of people; they do most good, when most distant from the part intended to be relieved according to the observations of Dr Willis A Thus we have finished the consideration of Sedatives; They should be applied gradually, whether the system be oppressed or prostrated; but cold water is an exception I cannot dismiss this subject without reminding you of the importance of these remedies in all diseases of action; all Physicians agree that in diseases of action we must I shall here speak of another class of sedatives remedies, which act first as gentle stimulants and exposed the excitability by degrees, - there are gentle exercise and action medicines; gentle exercise includes motion in a carriage and walking slowly - rheumatism and catarrh have been cured in this way among the certain remedies!!!! is opium in small doses in making use of these means of lessening the excitability, beware of ever letting the system descend to depression, oppressive [cross out] prostration (46) deplete, but they do it in different ways; 1 some leave nature to wear herself down; 2 Others stimulate to expend excitability; but then methods can only be proper in an excited healthy body, and not in an irregularly excited morbid body; if we leave nature to herself she will do mischief, and how much more proper would those [cross out] sedatives be, which take down the system without expending the excitability - Stimulating Remedies - There is a natural attraction in the system for aliment, and [cross out] aversion from Medicines; it is this aversion!!! which constitutes!!! the Modus Operandi!!! of Stimulants - Debility is the predisposing cause of disease, [cross out] which is always partial; Stimulants raise the system, but not in a Morbid degree - Stimulants have been divided into Stimulants, properly so called, and Tonics; Stimulants those medicines which raise the morbid body and Tonics, those which remove the Subsequent debility; but there is nothing gained by making this distinction: for the detail I refer you to Dr Barton's Lectures, Murray, and Cullen - Some medicines act upon the nerves; some upon  (47) the muscles; some upon the arteries and veins; others upon all the systems, a bark and wine; it is difficult to say when to begin with stimulants; the stages of the disease and the degree of previous depletion should be attended to, if they produce quickness of pulse, and fullness of the head and breast, they should be discontinued; but if they produce none of these effects, but rather enlarge and render the pulse slower, they are perfectly safe; thus it is easy to know when we have stimulated prematurely - 1. Soporifics are those medicines which are intended to produce long and profound sleep; sleep to do good should be profound, and long, to give time for the accumulation of excitability; in this way a gentleman of Maryland cured himself of a Typhus fever by taking a spoonful of Laudanum, which produced a sleep of 3 days and nights - 2. taking medicines in fevers of high morbid action are very bad, because they increase the fever; The Farriers of England overcome the most obstinate - A For he wished to cure disease by expending the excitability by degrees; but this can only be successful in weak diseases - (48) in horses by depriving them of sleep by mechanical means - Waking medicines are repeated small doses of Laudanum, an erect posture, conversation, strong tea and coffee &c. Rules for the exhibition of direct Stimulants - 1 Deplete before the exhibition of Stimulants, and do it equally, otherwise Stimulants would be in proper, this advice is directly contrary to Dr Brown's; A hence the following Dr Brown often fail in curing nervous diseases, because they deplete the nervous system only, and immediately attempt to Stimulate; nor can we stimulate one system and deplete another, thereby bringing them to an intermediate level, since we have no medicines which act exclusively on one particular system: hence you perceive, it is necessary to plumb (as the Carpenters express it) the blood vessels, which are the monarchs in the action. - Sleep cannot take place in less the systems be plumbed; thus if the nerves and the muscles be at the sleeping point, but the blood vessels above that grade, either from fever or too much exercise, our sleep will be A when we have reason to believe that the excitability is exausted, (49) imperfect; if the muscles be above par, Dr Franklin advised walking one's chamber, to equalize that System; an adodyne often fails of producing sleep, from the dose being too large, thereby raising the system above the sleeping point - 2. In accumulated excitability, ie, in the beginning of fevers; Stimulants should be given in small and frequent doses; by this means you will be able to approximate the quantity necessary to induce the sleeping point - 3. In the protracted state of a disease and in chronic diseases A the reverse is proper; we may give stimulants at once in the close of all most all fevers, and in the jail and Comp fever, at any stage of the disease; Dr Robins of the East Indies is of the same opinion in the practice upon Soldiers; if you were to give small doses the excitability would be gradually wasted without rousing the system, which would be doing harm - "Mella Medicina, aliquand. optimo Medicina;" thus it [cross out] sometimes happens that patients recover from Chronic diseases after having been given over by their Physicians; this arises from the gentle operation of the Stimuli of life  (50) being exactly proportional to the small quantity of remaining excitability, and thus creating healthy excitement - 4. Give single Stimulants at first, for then you have a greater numbers in reserve. 5. In the use of Stimulants, habit blunts the effect, in this case alternate the stimulants and recur to former ones; in this way, a much less dose will have its effect. [cross out] 6. After an internal of 3 months, a man had the same effect produced upon him by [cross out] one grain of opium, which 3 months before would have required 20 Grs: this often happens with bark; it sometimes produces no effect; omit it for some time, and then you may recur to it, often with success; we are sometimes unable to salivate; let us omit the mercury for some time, and then, by recurring to it, we may succeed - 7. It will often be necessary to apply the same stimuli in a different form; then Dr Whytt tells us that the dry opium may do good, when the recent [cross out] would produce no effect; also, heat, applied by sand, made no impression upon it - 8. Sometimes we must reduce the doses by degrees, and not suddenly; when a medicine becomes disagreeable, it is an indication that it is doing good, and therefore we may lessen  (51) it by degrees. 9. Change the part to which the stimulant is applied, for if a man always chew his tobacco on one side, it will produce nausea if chewed upon the other; hence when a the stomach becomes blunted to the power of [cross out] any medicine, twice the dose given by injection will produce the original effect; bark will produce its effect by injection. Tetanus has been cured by heat applied to the back - 10. A Stimulant which will hurt, when applied to one part, will do good to another; this arises from the different degrees of excitability of different parts; thus a cock was revived from a Stupefaction from electricity applied to the head by the same application to the breast; hence, might not opium in the rectum!!! counteract opium in the Stomach!!! 11. Certain Stimuli bear a relation to the thing for which they are intended to excite; this the tail of a leach is excited by electricity but not by the strongest alkohol, also if a nerve be paralized by acids it is restored by an alkali, but not vice versa - From what we have said it is perceived we require all the Stimulants, in order that we may find one which will vibrate with the state of the system; to give an exact A. 14th and lastly; always keep your eye upon the predisposition; without attending to this rule, you will often prescribe at random and some times will do more harm than good - B. wine, and certain authors of the mind - (52) analogy; the widow of the late judge Hopkins could not hear the report of a cannon, but that of a Musket, perfectly; in these apparent anomalous cases the less stimulus produced its effect by its being in exact unison with the tone of the fibres acted upon - 13. Remember the exacerbations of diseases; and take advantage of their weakest state, for the exhibition of your stimuli; for then they will act with more effect, the morning, for the most part, is the best time to give your stimulants, for then we are weakest, and consequently more excitable; it is from want of attention to this rule that we so often fail in curing chronic diseases A The Manner of action of Stimulants - Stimulants act - 1. By reducing suddenly Morbid action in every part of the body and which have been suppose to act as sedatives as opium!!! wine, violent exercise 2. They act by reducing morbid action by expending excitability; these are Digitalis, opium!!! in jar of lead, bark B 3 They act by removing morbid action by abstracting Stimulus from diseased parts - 4 They act by removing morbid action [cross out] by exciting a stronger and less diseased action in the affected A Coma from opium has sometimes cured and often suspended consumption; mania has done the same - (53) affected part, other part less essential to life - Rules to be observed when we use that method of reducing Morbid action namely, by translation - 1. Dr Darwin has found it necessary to produce delirium to relieve Convulsions, that is, he prefers convulsion in the - dias to convulsions in the limbs; I agree with him; in the same way Drunkenness has cured Dysentery and Tetanus A 2. The lungs are certainly slightly vital!!! organ; And [cross out] when we translate a disease to them, we may expect a recovery; I have always encouraged my patient when they have coughed in Yellow fever [cross out] It is sometimes necessary to translate to a more [cross out] vital part, in order to rest the diseased part, for fear it should be worn out, thus we produce Dysentery in Vertigo by a purge - [cross out] 3. When the counteracting [cross out] action becomes weak by habit, it will be necessary to vary the part to which it is applied; 4th here we may take advantage of the sympathies; by continuous sympathy we are enabled to throw the disease outward, and we translate a disease to the skin from the lungs by inverse sympathy - 5. Morbid excitement should be translated to different A The skin and the bowels, should be the place, above all others; to which we should invite disease - B when we wish to attract gout from vital parts - C. Here we should follow the suggestions of nature and give gentle purges, and make use of warm applications - (54) different systems; purges remove many diseases in this way; and in Tetanus the cure is generally attempted by translating the disease, from the muscles to the nerves and blood vessels A 6. Morbid action should be translated as distant as possible from its original seat: thus applications should be made to the feet in diseases of the head - 7. We should discover the weakest parts, or, the ball of the big toe, and the ankle, from walking, as proper for the application of Cataplasms; B but if there should be no weak part, make one by exercise and long friction; if going upstairs cures drunkenness, it can do it in no other way, than by weakening the extremities - 8. Observe the tendency of nature: in Infancy, diseases of the head relieve themselves by sores behind the ears, therefore in diseases of the head in children, take advantage of this indication of nature, and make your applications there - In Youth, the determination is to the lungs, therefore use blisters to the arms sides and breat; in old age, the tendency is to the bowels, and lower extremities - C of Tonics - Those medicines which are fitted to remove debility are called  (55) Tonics; debility is the predisposing cause of all diseases, sometimes it is so great as to produce death without disease; Tonics act as Stimulants, that is, either by sympathy or antipathy - Rules for the exhibition of Tonics - 1. They must be given sparingly, when to overcome debility simply, but when they are intended to remove morbid action, they must be given in greater quantities; hence when we give bark for a fever, we order ℥ii a day, but when for debility simply, ʒss 3 times a day - 2. In debility, we must persist in their exhibition for months, and sometimes [cross out] even years; these remedies were called by the Romans, Annalia - Tonics have been divided into aliments drinks and Medicines - 1. Aliments should be proportional to the state of the system, and according to its strength may be either arrowroot Saloop, Tapioca, Sage, Potatoes, broth, Baked apples, or Rice - 2. aliments should be of the most pleasant kind, for the pleasure acts also - 3 They should be 4 or 5 times a day, and if our patient cannot sleep, twice at night; for the stomach, like a School boy, is certainly at his chief if not employed - 4. Solid food is more proper in chronic diseases, but  (56) liquid in acute; farmers will tell you that those animals which are fed in liquid food will have more fat, but less flesh; it is because solid food yields its nourishment more slowly that it is more proper in Chronic diseases - 5. In chronic diseases, indigestible substances are often necessary to excite the system to a more vigorous action - 6. The less nourishing the food in chronic diseases the better; hence we should prescribe solid vegetables rather than Meat, and Salt meat rather than fresh, in consumption, when the patient is very weak, and we fear hemoptesis, Salt meat is to be preferred, as it will invigorate the system, without filling the blood vessels, Hippocrates tells us, "the more you [cross out] nourish [cross out] a weak body, the more you hurt it - 7. The diet which you prescribe, should be regulated by the national habits of your patient; thus, for removing debility in an Englishman, order cheese, beef stakes and porter - In a Scotchman, oat Meal, [cross out] & Barley broth - In an Irishman, potatoes and sawins Butter milk - In a German, Sour Crout - In a Dutchman, a herring - In a Spaniard, garlic and Onions - In a Frenchman, Soup Maigre -  (57) In a native of North or South Carolina and Georgia, Rice in the form of pilar - In a native of Virginia, Maryland and Delaware, Hog and Hominy - In a native of Jersey, Pennsylvania or New York, Poultry, Eggs and oysters - In a native of New England, Pork, Molasses [cross out] Peas and onions - 8. You must not always forbid eating, because your patient has no appetite - 9. Give a homogenious diet; remember that the british officers, confined by Tippo Saib, were protected from the diseases of India, by living upon two founds of rice every day; Milk has cured Rheumatism and gout, and Carrots, asthma in the father of judge Cooper. - Great advantage arises from eating at a uniform hour in debility; this is an objection to travelling; some persons get sick, if they have to wait for their [cross out] dinner, but a quarter of an hour - Malt liquors and wines are Tonics, they contain aliment; by mixture with Sugar, they are rendered more Tonic; they are Tonic in the following order; [cross out] Malt liquors, as Porter and  (58) ale, then the high wines, as Madeira Cherry &c then the low wines, as Champagne, Burgundy, cyder; I exclude ardent spirits, for although they [cross out] may preserve life for a few years, they invariably make drunkards, and it would be far better to let your patients die of debility, than by such detestable [cross out] brunonian medicines, to preserve life for a few years: the intoxicating power if liquors is increased by sipping - Baths as Tonics - Baths are called warm when between 100 and 110 degrees of heat; cold bath contracts the body; hence rings fall off the fingers; involuntary flow of urine, and prolapsus ani take place - 1. Cold water should not be applied, while the body is sweating, or debilitated - 2. When applied, it should be for a short time - 3. The head should always be wetted; it is to be preferred at 12 O'Clock - 4. The patient while in the bath, should be constantly in motion, and when out, frictions should be used - 5. Baths should be used twice a day in most diseases to do good -  (59) The shower bath is good is diseases of the [cross out] brain The hot bath is necessary only in protracted debility when the system is in a Stricture state, that is, with rigid fibres; the hot bath dissolves the blood, and the warm bath enlarges the body and increases the pulse; it discharges much less perspiration than the hot bath; it does most good at 12 O'Clock, it may be continued from 10 minutes to two hours and an half; if used a long time, we cause debility by the pores; it is an excellent remedy in that form of Madness called Manalgia; the Indians cure fever in this way; Dr Franklin used an air bath to invite sleep; his method was to sit in a chair with only a shirt on; Baths are sometimes used of hot water and Salt, or Nitric acid, as also of dry salt or dry sand, dry clay, oil and vapour - Mineral Waters - They have been recommended by all ages and countries; we should always go to their source, if we wish to use then with advantage, for they lose much by transportation; they have been improved by art- They act in 3 days - A. They produce their salutary effect by imparting a stimulus to the whole of the stomach; they are rendered more efficacious when taken warm - it was formerly supposed that they acted by their quantity; but this is a mistake and it is now found that 2/3rds of a pint taken at two draughs before breakfast and 1/3rd before dinner is sufficient - 2 It promotes perspiration (60) 1. By their ingredients - 2. By their temperature - 3. By their quantity - The ingredients which in part tone, are principally, the carbonic acid gas, Iron and the Sulphurous acid gas A They often do harm the first two or three days after being used, but afterwards, good; but if no benefit should arise after being used for a week or 10 days, their use should be discontinued - Mineral waters are very useful in affections of the stomach, bowels, and nerves; I take no notice of the purging Mineral waters. Exercise as a Tonic - Both Exercise and Rest are Tonics, according to the state of the system. Exercise has the following effects; 1. It increases the circulation of the blood - 3. It increases the action of the absorbents - 4. It promotes Sanguification - 5. It increases Strength; - 7 and lastly, it removes visceral obstructions - A The dry hand has discussed tumours when rubbed upon them for several hours - (61) 6. It prevents and often cures obesity, who ever saw a fat Sailor or Soldier, Exercise may be divided into 3 kinds; active, or walking; passive, as in a Carriage, and mixed, as on horseback; frictions are good, it is called in the east Indies, Shampooing; [cross out] frictions the dry hand is best; A it has removed puking: sometimes flour is put upon the hand; the flesh brush, or a rough cloth is good; frictions on the sound arm has cured Palsy upon the opposite side - Rocking in a cradle has prepared the system to be cured by more active [cross out] remedies in Consumption; & sea voyage is also good, it agitates the muscles, and excites the stomach and mind; if you want dry air, send your patient to the middle of the ocean, for there, little!!! evaporatin!!! takes place; swinging is a Tonic, it renders the pulse slower and fuller, I know this from experience, I have cured Consumption by it; a box made to perform a rotatory motion is good in Chronic Madness - I have called [cross out] it a Generator. Riding in a carriage is a popular remedy; it differs very much according to the construction of the carriage - it is possible Balloons may supercede the [cross out] use of carriages in affording that passive exercise for which at present the Carriage can only be used; it would  (62) enable the invalid to travel though air, purer than that which is near the earth - Suspension by the arm, and the lifting of heavy weights are often used in debility; partial exercise will increase the heat of a particular part; thus the hand would communicate considerably more heat to a portion of water if exercised in it, than if it be left without motion; partial exercise sometimes produces general good effects, as in Taylors, weavers, and Shoemakers; riding on horseback is a mixed exercise; talking loud is a mixed exercise; silent women are generally unhealthy. A respectable Physician accounts for the frequency of consumption among the women of the society of friends from their never singing; Watchmen Sea Captains, organists [cross out] and Trumpeters are generally long livid, and never affected with Consumption - The affection of high life, which forbids laughing has destroyed one of our greatest pleasures, it strengthens the lungs; it adds to life as Sterne says; the habit of wispering in high life has increased the number of Consumptions; even Children should be taught to halloo very loud when out of school. A dancing - (63) General excitement is walking, running, shuttlecock and nine pins A &c - together with all labours whether agricultural or mechanical; Celsus says, walking is more exercise when up or down hill; the Indians, when tired by walking, take up a small log, to restore their strength; it acts by [cross out] rousing their excitability; thus also dancing Masters dance in boots, to walk them to dance better with pumps; exercise in the open air is always preferable - I have heard of two cases of Dropsy being cured by falls; the one, by falling from the yard arm of a ship; the other, [cross out] from the tape a worm; what would be the effect of prescribing jumping from a certain bight, in some chronic diseases; the Indians Dr Alex Drummond wished to obtain all the advantages of exercise by using the cold bath; but he did not succeed; in short there is no substitute for exercise - 3. Exercise should never be taken before breakfast, nor after night, for in the morning there is too much and in the evening too little excitability - 4. Attend to the occupation of your patient -  (64) 5. The kind of exercise is in a great measure regulated by the seat of the disease; thus riding on horseback should be recommended when the stomach lungs or bowels are affected, Motion in the arms should be prescribed in pulmonary consumption; digging in a garden if the kidnies are affected; walking when there is weakness in the lower extremities; as well might we tell a patient to take medicine, without suggesting a particular remedy, as to prescribe exercise, without telling what kind - 6. Exercise to do good should be constant; Dr Sydenham mentions this; here we have the reason why the Soldiers of Greece and Rome were so healthy - 7. Fatigue often prevents the good effects of exercise - 8. Sometimes we may remove chronic diseases, by changing the occupation of our patients; I have cured a Hatter by placing him in a iron mongeri stori; I have cured many boys, by removing them from sedentary to active employments; a change of dwelling is often a means of curing of diseases, as also by removing from the city to the country, or even by a change of dress; changes always relieve, A Into its previous state of debility - (65) we relieve ourselves from sitting by standing, and standing again by walking; thus also we relieve one foot by standing on the other, like the chickens [cross out], change of dress is often pleasant on another account than the mere novelty; for it often pleases by associations, the origin of which the mind does not notice, thus to put on a coat which we wore at some agreeable place, gives pleasure, although we do not think of the circumstance at the time; this is a very curious fact; we should be as particular in choosing a situation for health, as for pleasure - Travelling I distinguish from short excursions from home; by travelling I mean, taking along journey; by this means we prevent the system from colapsing, A Dr Sydenham was well aware of the importance, but he adds, to do good it should be constant - Rules for Travelling - The following circumstances should be attended to in travelling - 1. Food and drinks should be carried with our patients, in order to avoid the inconveniency of long stages - 2 The patient should be down between every stage for we are more refreshed by one hour's lying, than  (66) sitting - 3. The patient should attend to the room, examine whether there be a window open, or a piece of glass broken, or whether the chamber be damp - The Invalid should avoid company; watering places are often the passports to the grave to many in debility; in pain the landlord makes noise an item in his bill; some persons are too debilitated to exercise their intellectual faculties, thus Dr Johnson sent word to Burke, that he [cross out] was too weak to see him, that [cross out] his conversation was too much for him, [cross out] it was a stream of mind - Sea air is a wonderful thing; it cannot be imitated by art; hence Venus is said to have sprung from the Sea; Sea air is useful in many diseases but in _ or consumption; a sea voyage acts, from having no one to acquire after our health; many are made worn by such inquiries, a man's asthma was uniformly increased by the inquiries of his friends; a husband cured his wife of a chronic disease, by giving her a dollar a day, if she would not complain - 2. If the disease arise on high, we must direct our patient to low and level countries - (67) Living in the Country increases the size, as also longevity; in this way the Romans kept Health at bay, for a long time by removing to naples, and the Portuguese, by going to South America - Rules for changing the Climate - 1. If it be a disease of heat and moisture, send your patient to a dry cold climate - 3. The stay in a different climate must sometimes be for life, and never for less than two years - 4. We may make a substitute by art for heat, cold or moisture; if you wish heat, let your patient live in a Stove Room; if cold; let the appartments have double windows, with buckets of ice between then, as is done in Russia; if you wish for moisture but a basin upon the stove; and do not let the patient move out of the room; this I have called a hybernating remedy; the patient should not take tonics at this time - The pleasures of the Senses are a great Tonic even tobacco becomes useful, if long used; the use of the pleasures of the senses, I have published with  (67) my introductory lectures - I took notice of the effect of conjugal felicity; sometimes wine and intoxicating remedies may were diseases; smelling a flower garden has in Some instances done more good than [cross out] taking pounds of bark or steel; the smell of spices is excellent in some diseases; the smell of Tar has cured Consumption, and even Music alone has cured debility - The pleasures of the mind are often useful, as the intellectual, moral, social and domestic pleasures. - It is often well to infuse hope; it is the vehicle in which all over our medicines should be given; I saw a patient much invigorated by this Physician saying, that it would puzzle him to die of his disease, if he wished it, but great cures have been affected by a contrary manner; such as by a solemn countenance and even insults; remember the hypochondriacal lady and Cullen - Electricity and Galvanism as Tonics - On this subject I can say nothing from my own experience  (68) experience; they are tedious and expensive remedies - Gases have done some good; oxygen and the nitrous oxide have removed pains in the breast, but their effects are but transient, and they are difficult to be procured - In great debility, rest is a tonic, especially if it be accompanied by silence, and exercise, a sedative; you should, in chronic diseases, require your patients to go to bed early; Dr Sydenham advises this; at 9 O'Clock the system requires sleep; the patient should use a feather bed in winter, a Matrass in Summer; the patient should never sleep upon the back; sleep should be taken in an easy chair when there is too great a tendency of blood to the brain, or a disposition to headach after sleeping horizontally - Medicines as Tonics - I have left the consideration of Tonic medicines purposely to the last; they are derived from the vegetable animal, and mineral kingdoms the vegetables are  (69) Gentian Colombo, Bark, Calamus, Garlic, Tar &c among the animals, we have Musk and Castor; among the minerals we [cross out] have the preparations of loin and head; so that Iron, & lead, instruments of death in the hands of the Soldier, in the hands of the Physician on the preservation of life; Iron is the only substance which creates strength, without subsequent debility; perhaps because it affords the principle of excitability; Mercury is a great medicine in chronic diseases, like change of climate and diet it is a revolutionary remedy; it should affect the mouth: an ancient philosopher said, "why did that man die, while sage was growing in his garden"; and I say why are there deaths from debility while Tar, Garlic and Iron are to be procured, and swallowed; Dr Young, speaking of his chronic debility, says he was kept alive by Tar water in winter and Steel in Summer. - The exciting causes of debility should be avoided, such as costiveness venery, Tobacco, Cold, especially cold feet, tight ligatures &c Some Physicians cure debility with one remedy, some with A. Dr Physick teaches us that the external remedies most proper here are blisters; the internal dark wine and opium. B. The quantity of a tonic clyster should be small; not to exceed 4oz. (70) other, but all, all, all are often necessary and barely sufficient for the cure of some cases - Gentle Stimulants should be used when the excitability is accumulated, as in asphixia, such as cold water and a burnt feather; in frozen limbs cold water should be used - 2. Sometimes the excitability is exausted, and the excitement prostrated, as in the beginning of a Malignant fever, or the close of a Typhus, here very violent stimulants should be used, such as caustic, hot iron &c - 3. In Gangrene, in which there is neither excitability nor excitement in a part, all that can be done is to remove it by stimulating the adjacent parts A 1. Some medicines produce their effects by licking; thus a mug of Strong beer if sipped gradually, will produce intoxication - 2. The Tonic medicines may be administered by Clysters; in this way aliment, bark and opium may be administered, B for the bowels retain there irritability longer than any other part of the body; they even  (71) retain it after death. 3. Some produce their effects though the medicine of the nose, as volatile Salt, Camphor spirit cephalic snuff &c - 4. Some, by the lungs, as the vapour of Tar, the smoke of resin, Ether, and garlic - 5 Others, by the skin; a book was published at Montpelier by Dr Prestiene, who cured diseases by medicinal frictions; he made use of camphor, opium, &c the form of liniments; if they did very good, it was the mere friction - Frictions are of most service upon the stomach - navel, belly, the inside of the thighs, the soles of the feet, the back bone, the arm pits, and near the anus: Tobacco or Stramonium applied to the stomach produces vomitting, sweet oil to the belly, has cured Dropsy - Frictions act in 3 ways - 3. by sympathy; tobacco and Stramonium act in this way - External Stimulants act less well in adults than children; hence the reason why garlic, Turpentine  (72) Ether and Laudanum act is certainly in children, garlic [cross out] in spirits, and applied to the back bone is good in the whooping cough of children - 1 of Medicines which remove Disease by abstracting, redundant and foreign matters from the body, [cross out] which offend by their quantity or quality - We come now to speak of those redundant matters, as bile, fœces, worms, pus, air, water, stones which are removed by purges, anthelmintics, lithontriptics, depletiars, Deobstruents, and lastly Surgical operations 2 Some medicines act by mixing with, and thus destroying matters which offend by their quality - 3 Thus Calculi in the kidnies have been cured by lime water; the sulphuric acid is said to have the same effect; mercury destroys the bubo by mixing with the venereal [cross out] virus - 3. Some medicines cure disease by removing obstruction; [cross out] this latter is generally the effect of disorder, the remedies are bark, iron, mercurial frictions, and fasting so as to render the lymphatics hungry; fear has sometimes 1. according to its causes - A. The remedies under this head are bleeding sweating and purging (73) cured [cross out]; in this way the royal touch has cured Scrofula - 4 Some medicines cure diseases by changing the quality of the fluids; they are called deobstruents; they remove fator from the bowels; they are the different kinds of teas - worms are destroyed by certain poisons - 5. Some medicines cure diseases by changing the texture of the Solids; gain certainly alter the aggregation of the fluids and solids; but they are not so useful as was expected; Dr Beddoes gave them up before his death - of Remedies for the relief of Pains - Pain is the effect of disease; it causes are either mechanical or chemical; pain is sometimes a remedy - These remedies act. 2. According to the seat, whether it be internal or external, or in a more or less important system - 3. According as it is chronic or not - 4. According as it is constant or not - Depletion is necessary in pain; A cholic is a - A and thereby obviated the pain - (74) pain, and is therefore cured by copious bleeding; fasting is a cure for pain; hence a man fasted who was about to be tortured; A 4. Cold air relieves pain; a painful limb has been relieved by being thrust out of bed, 5 cold water is good in hæmorrhoids, arthritic gout, and Rheumatism - 6. Hot or warm water relieves spasm in the stomach and when injected into the bowels it relieves cholic and nephritic complaints 7. Demulcent and oily substances relieve pain; poultices of sweet oil will remove pains in the belly; oil lessens the pulse, as was proved by Dr Jackson of Georgia; hence the Roman had no Rheumatism, for they bathed in oil, and used oily perfumes 8. Gentle frictions of the hand will remove pain - Much water will relieve pain, but a little produces the most intense pain - 9. violent frictions remove pain; it was in this way Capt Cook was cured by Cholic by the natives of the Friendly ilses; Capt Lewis speaks of the native of the western coast of america [cross out] treading on the belly -  (75) belly. Mustard Cayenne pepper, Ginger, a hot iron, have all relieved pain Dr Davidson cured his gout by barely touching [cross out] the affected part with a red hot iron, a dutch Physician got great credit for curing the toothach, by cutting the nerve!!!! - During a surgical operation, you should allow your patient to cry out; a french Marquis expired from being too proud to cry out when cut for the stone - Soldiers often alleviate the pain of whipping by biting a bullet, they also bite the ground in the agonies of death as Homer tells us; horses cure their cholics by biting the Hanger, hallooing relieves hare, a man got two black!!! fellows!!! to cry!!! out which he as suffering some severe pain; water relieves pain, as in the case of Lord Nelson, as also rest in a recumbent posture; unemployment has the same effect in Rosiosco; he cured the pain of his wound by the employment of [cross out] Fever, when in prison in Petersburg - Passions alleviate pain; the sight of a long absent friend has cured the toothach; the Indian are very often unable to feel pain from the anger produced by the A except we concentrate our minds on the misterious process - 2. we know that the natural pains of mankind such as parturition in women are alleviated by coming on at intervals; what would be the effect of making surgical operations at intervals!!! ? B. sorting as to produce Coma, as a slight degree of apoplexy - (76) results of their enemies; animal magnetism has no effect in relieving pain; A On Surgical operations - 1. nature pain comes on gradually, but this is not the case [cross out] in surgical operations; this suggests the propriety of bringing on the pain of Surgical operations gradually, for we all know that the blister produced by hot water is unsupportable, but that by cantharides [cross out] comparitively trifling - [cross out] 3 Women have brought forth Children without pain, when intoxicated, why not then give a strong dose of opium B just before a Surgical operation - 3. Singing has cured Gout; the noise of cannon has prevented the sensation of a wound; what would be the effect of beating a drum during a Surgical operation!!!! - Of the Means of promoting Longevity - Strength is not health, a watch spring can last as long as an anchor, if the force applied to each be proportional to its strength.  (77) Dr Sydenham tells us that to cure acute diseases, does not always prove that the principles, upon which the cure depended, were correct, thus yellow fever has been cured by bark and wine, but this is an unnatural method of cure, thus lso, there are 3 ways to get into a closed room, by the window, and by breaking open the door and by unlocking it; but there is but one natural way, [cross out] that is, the last mentioned; there are two ways of going to Charleston, by hugging the shore, and by means of the compass; but the last method is best, because it is the method of principle; a man threw shingles into the sea to know the way back from the west Indies; [cross out] but gentlemen, the waves of the sea are not rendered more certainly instable by the winds, than the operation of medicines, by a thousand different circumstances - Bonaparte, with all his victories, has not invented a new mode of killing; Dr Johnson said that good writing consisted in proper words in proper places; thus gentlemen, good practice is proper medicines in proper doses, places, quantities and times -  (70) Perish all the imitating horn book Physicians who move in the old beaten track of medicine - A. They bring both units - (79) Practice of Physic - We now come to the last part of our course, in which we have to apply the Physiology, Pathology and Therapeutics which we have just finished, to the Practice of Physic - The question arises; how shall we treat of diseases some say, by classes, as animals and plants; this is called Nosology; Dr Sydenham have first suggested this plan; then it was followed by Sogar Rogel Sauvage & Linnæus and Cullen; fashionable studies have often given rule, unjustly to other sciences; The following are my reason for rejecting nosology - 1- Because it is in compatible with anatomy and Physiology, A for some viscera are [cross out] insensible; and between other parts these exists such an intercommunion of sensation, that the one is never affected without the other; this is the case between the stomach and bowels - 2. nosology is incompatible with the causes of A. 3. It is incompatible with the effects of climate, predisposition and a lessen of years - this the same &c. (80) diseases, because the same cause will bring on different diseases; and the same disease may arise from different causes, as from cold and intemperance - [cross out] A The same disease is different in different persons, from climate; time has the same effect as in the case with Leprosy; the asiatic plague and our yellow fever are the same disease, but how different from climate! 4. nosology is incompatible with the changes in Epidemics, where shall we place Dr Sydenham's variolous disease - 5. nosology is incompatible with the seats of diseases, for we see the same disease, [cross out] attacking every parts of the body in percussion; [cross out] thus rain is rain whether it fall upon the hills or valleys, and a club is a club whether we receive from it a blow upon the head or any other part of the body; why do we not call gout by different names according to the part of the body, which  (81) it attacks, we never say Gouts; we might [cross out] as well have different kinds of death, as different kind of disease: how absurd it would be should I call myself by a different name, when in this or that corner of the room? equally absurd gentlemen is it, that disease should be called by a different name when in this or that corner of the human body - 6. nosology is opposed by the illusive nature of symtoms, and the want of them altogether; thus in the East Indies the liver is absorbed, without giving the least pain; consumption is often in attended by pain; besides We are deceived by Dr Hunter's delusion sympathy; who can tell which is the original affection, when a nausea and headach exist together - 7. nosology takes no notice of the stages of disease; to this circumstance I know of no exception - 8. It is contrary to truth; (here he points out two errors in Cullen) thus Cullen calls apoplexy, Palsy [cross out] and Mania, nervous diseases, where as they A More especially those affecting the viscera The cases in which nosology has done harm - (82) are arterial; Dropsy and Scurvy he calls cahectic diseases; whereas all Dropsies, and all Scurvies but one, are cured by bloodletting!!! - 9 nosology excludes the diseases of children A 10 And the diseases of brutes - 11 nosology has made no provision for new diseases or new forms of old diseases - a Frenchman was about to be executed; his priest told him, he could not find in his book a single prayer which suited him; another Clergiman got up and made an extempore prayer, suited to the occasion; behold a parallel [cross out] to a nosologist and Unitarian; thus Gentlemen, you should be extempore Physicians - [cross out] 1st, nosology has done great harm by preventing us attacking diseases in its germ, and by teaching us to wait untill a disease unfolds itself into its appropriate genera and Species; under this impression, a Physician in berjuice would not prescribe for two days in a fever; believe me Gentlemen, A and a gangrene, a wither from heat or cold is the same disease, and requires the same remedies - B. Whereas, when from the forum it is treated by bleeding, but when from the latter, by vermiferge medicines !! - (83) Gentlemen, you might with the same propriety delay the to extinguish a fire, untill the manner in which it caught was ascertained, as not to prescribe for a disease, untill the cause is known - 2. nosology has done harm by teaching that there are as many different diseases as predisposing causes; thus an inflammation in the lungs, whether from gout or cold is exactly the same A; and dropsy in the brain, whether from contusion or worms, should be treated in the same way, B - 3. nosology has done harm by requiring different remedies for every stage, supposing them to differ specifically - 4 nosology has done harm by supposing disease to be different, because in different parts; thus Mania and Hepatitis depend upon the same morbid action in the pulse, and yet how different they are treated [cross out]; Mania and Rheumatism, are also the same; in short Mania is Rheumatism A. about the cause, the seat used the names of diseases - (84) Rheumatism in the brain, and Rheumatism, madness in the joints!!! - 5. nosology has done harm by multiplying remedies, thus we have brain worts, liver worts, spleen worts, bowel worts, and womb worts - On the other hand the unity of disease gives as a select number of remedies - 6 nosology has done harm, from its having created disputes among Physicians; A 7. nosology has done harm, because it subjects us to the charge of the uncertainty of medicine, whereas the unitarians think it of no importance to discover the seats of diseases - 8. nosology has done harm by [cross out] under valuing the works of Sydenham, which are of as much importance to the Physician as the bibles to priests - 9. nosology has done harm by requiring no thing but memory for acquiring a knowledge of medicine; nosology  (85) nosology may be compared to a cabinet in which there is a great number of small closets, to each of which the nosologist has a different key; but the Unitarian has but one key, with which he opens [cross out] them all; Recollect the involuntary exclamation of the quaker to his horse; "Thou hast a good memory, horse, but a [cross out] very bad judgement"; the same may be said of the nosologists; they have good memories, but [cross out] no occasion for judgement - Every stage of a disease requires great attention, and often appropriate remedies; thus we see, that nosology instead of being useful is hurtful, in as-much as it prescribes the same remedies in every stage of the same disease. In the mixture of Epidemics, from the influence of season, we are often under the necessity of using, not only different but even [cross out] opposite remedies in successive years; further, the quantity and strength of a remedy should be  (86) varied by the importance of the part affected by disease; thus an inflammation of the brain requires more prompt remedies than an inflammation of the joints; as also, an inflammation of the trachea requires more attention, than the same disease in less important parts. But, Gentlemen, I have been accused by my brethren of rendering the practice of medicine, too mechanical, and at the same time, too simple; as to the first charge, I deny it; so far from being mechanical, my opinions are more dependent upon reason, and requires more in turn thought, than perhaps any other system in the knowledge of man; besides it is attended with more solicitude, for we must not only visit our patients frequently, but even in some urgent cases, watch every change in the system, for they will vary the [cross out] exhibition of Medicines. But it has been urged that many great and successful Physicians have been nosologists: this I admit;  (87) but here it must be remembered that their Principles only were nosological; it was thus with Sydenham Boerhaave, Cullen and Huxon; these men were Unitarians in practice. - But why have the nosologists not gone through with the matter, they have divided great diseases without applying the principle to smaller ones; thus the symtoms of a diseased cerebrum, and diseased cerebellum are not only different but quite distinct so also are the symtoms of the diseases either of the trachea, glottis epiglottis, pleura, and the concave and convex part of the liver; but who has ever dared, however infatuated a nosologist he might be; nay who has ever dared to offer such an insult to human reason as to give a Cerebretis, a Cerebelletis, a Trachetis an interno-hepatitis, an externo-hepatitis a Glottitis, an Epiglottitis, and Pleuritis!!!! - where was the mighty reason of Dr Sydenham when he suggested such vague illusive and preposterous ideas; but yet his invaluable treatise upon epidemics turns the scale in his favour - Here Gentlemen I have ended my reasonings against  (88) against the old nosological system, and let me be - reach you to cast back this 3 headed monster, this man destroyer to that dark abode, from which no being but an inveterate for to Mankind could have let loose upon [cross out] the world; there let him gnaw his own chains amongst the piles of musty books, which he has reared to mislead and perplex Mankind, and let no Mortal have Mercy on him - But yet we must conform to custom; we must in some measure bend to the tyranny of prevaling opinions; there are some truths which require strong heads to embrace; such is the belief in the unity of disease - A Lady in London having been bled by an eminent Surgeon, sent for him to examine a blackish appearance around the orifice: the Surgeon gave her no name for it, but told her to its was very common; [cross out] she then sent for another Surgeon, when was in like manner unsatisfactory; but the third gave her case, for he gave her name for it; it is an ecchymosis Madam, the lady took his prescription with confidence, [cross out] with  (89) the highest notions of [cross out] his minute knowledge of his profession; then gentlemen we must ecchymose, or in other words we must give names to diseases if it is our intention to succeed in our practice - Dr Brown's classification of diseases - Dr Brown divides disease into [cross out] sthenic and asthenic; but I reject this division) - 1. Because even the lowest diseases are attended with some inflammatory action - 2. Because he does not give each division its proper proportion; he says the asthenic take place oftenest - 3. Because the same disease is often first weak and then inflammatory, and vice versa - Dr Darwin's division of Diseases - Dr Darwin has divided diseases, into those of sensation motion, association and volition - But this division is founded on the phenomina exhibited under the influence of the healthy sympathies of the body; and it is therefore grossly incorrect, as these sympathies are destroyed in [cross out] A as Hectic fever, the blood vessels - (90) disease and return with health; thus the return of the sympathy between the nose and diaphragm in sneezing is an indication of convalescence - Dr Darwin's theory of disease may, not ineptly, be compared with the famous and brilliant russian bridge of ice, its dazzles from the genius exhibited in the structure, but is dissipated by this influence of the first vernal Sun - I formerly divided disease according to the system they attacked, as for example, into arterial Hepatic nervous, muscular, cephalic, phrenitic, alimentary lympatic and Cutaneous diseases - I was led to this divison- 1. Because some diseases affect some one of these systems nearly exclusively; A such as Dysentery, affecting exclusively the intestines and syphilis, the lymphatics; Tetanus the muscles and Hysteria the nerves. But when I considered that disease sometimes affected two, three and even all the systems at once, and also that morbid excitement often left one and seized another system in the same fit of sickness,  (91) I was forced to abandon this decision and set sail once more on the tide of uncertainty, rather than to be satisfied with having put in at a wrong part, and thus have I been beaten about in the pursuit of truth, with reason as my [cross out] compass, untill my lawdable recherches have been crowned with success. I have at last found the only spot of ground, upon which I can rest with safety, and build a consistent theory of the practice of Physic; it is gentlemen in the belief in the unity of disease - It is a dificult thing to arrange a science; it has been compared by the schoolmen to an Eel and a circle, to the former, as being difficult to seize, to the latter, as having no beginning nor end. - Of the Phenomena of Fever. The Blood vessels, being the Watchmen of the system, and their motion bring essential to life, are the most usual seat of disease, [cross out] and when it happens, it is called Fevers - Before I proceed upon the phenomena of Fever, I  (92) shall beg leave to deliver a few general propositions - I Fevers of all kinds are proceeded by general debility; this debility is natural or accidental; the former is the effect of the sanguineous predisposition and exists at all times in many constitutions: the latter is induced 1 By such preternatural and unusual stimuli, as after first elevating the excitement of the system above its healthy grade, and thereby wasting a parts of its strength, or what Dr Brown calls excitability and Darwin sensorial power, afterwards reduces its down to that state which I shall call debility from action or 2. It is produced by such an abstraction of natural stimuli as to reduce the system below [cross out] its healthy grade of excitements, thereby inducing what Dr Brown calls direct debility, but what I shall call debility from abstraction; where this debility is induced by abstraction, the system becomes more excitable, and more liable to an attack of fever, than when it is induced  (93) induced by action; but to this there is an exception, and that is when the remote causes of fever act with so much force and rapidity, as suddenly to depress the system, without an intermediate elevation of it, and before sufficient time is given to expend any parts of its strength or excitability, or to produce the debility of action. This debility from action is moreover on a footing with the debility from abstraction when it is of a chronic nature. They both alike expend so much of the quality or substance of the excitability as to have the system in a state in which irritants are seldom able to excite the commotions of fever, and when they do it is of a feeble nature, and never we observe persons who have been long exposed to debilitating causes often escape fevers while those who are recently debilitated are affected by them, under the same circumstances of exposure to those causes - That fevers are proceeded by general debility. I infer from their causes all of which act by seducing the excitements of the system - by the abstraction of  (94) stimuli, or by the excessive or unusual application. The causes which operate in the former way are 1. Cold - This is universally acknowledged to be & predisposing cause of fever; and that it debilitates I infer 1st from the languor which is observed by the inhabitants of cold countries, and from the weakness which is felt in labour or exercise in cold weather: 2nd from the effects of experiments, which prove that cold air and cold water lessen the force and frequency of the pulse - 2 The debilitating passions fear grief and despair 3. All excessive evacuations, whether by the bowels, blood vessels, pores or urinary passages - 4. Famine or the abstraction of the usual quantity of food The causes which predispose to [cross out] fever by the excessive or unusual application of Stimuli are 1. Heat. Hence the greater frequency of fever in warm climates and in warm weather - 2. violent emotions and stimulating passions of the  (95) mind - 3. Unusual labour or exercise - 4. Intemperance in eating and drinking - 5. Certain causes which fact by overstretching a part or the whole of the body, such as lifting a heavy weight; also external mechanical violence, or extraneous bodies acting by the gravity, burning and the like. The influence of debility in predisposing to fever is further evident, from their attacking so often in the nights, a time when the system is more weak than at any other in the four and twenty hours - II Debility being thus formed in the system by the causes above enumerated, a Sudden accumulation of excitability takes place, whereby a predisposition to fever is created. It is not always necessary that a fever should follow this state of predisposition. Many people pass [cross out] days and weeks under it without being attacked by a fever by carefully or accidentally avoiding the application of additional Stimuli or irritants to their bodies.  (90) But the space between this state of predisposition when recent and fever is small; for independently of additional Stimuli, the common impressions which support life sometimes become irritants, and readily add another link in the chain of causes which induce fever; and that is III Depression of the whole system, the indirect debility of Dr Brown. It manifests itself in weakness of the limbs, inability to stand or walk without pain, a sense of fatigue, a dry, cool or cold skin, chilliness, a shrinking of the hands and face, and a weak or quick pulse. It is not necessary that a paroxysm of fever should follow this depressed state of the system; many people, by rest or by means of gentle remedies prevent the formation of fever; but when these are neglected, and the action of stimuli whether morbid or natural are continued. IV Reaction is induced, and in this reaction, according to its greater or less force and extent consists the different degrees of fever. But let is not be thought from this that I admit Dr Collin's supposed "vires naturæ medicatrices"; to have the least aging in this reaction of the blood -  (97) vessels. I believe it to be altogether the effect of their elastic and muscular texture, and that it is simply mechanical as the motions from impressions from other kinds of matter - The reaction or morbid excitement of arteries discovers itself in preternatural force [cross out] or frequency in the pulsations. To this remark there are some exceptions - 1. The arteries are sometimes affected by great morbid excitement, while the natural functions of the heart are unimpaired, as occurs in some stages of consumption and hectic fever - 2. The heart and pulmonary are sometimes affected by great morbid excitement, while the pulsations of the arteries at the wrists are perfectly natural - 3. The morbid excitement of the arteries is sometimes greater on one side of the body than on the other, proved by the strokes of the arteries not being synchronous, and the different appearance of the blood drawn from both arms at the same time  (98) 4. The arteries of the head lungs and abdominal viscera are sometimes excited in a high degree which the arteries in the extremimies exhibit Marks of a feeble action; this occurs most frequently in malignant fevers - While morbid excitement thus pervades the sanguiferous system, a debility in the stomach, bowels, and muscles is induced by their excitement being abstracted and translated to the blood vessels - this principle is illustrated by what takes place in Tetanus, where it appears that every particle of excitement is concentrated in that one system alone - I shall now endeavour to illustrate the propositions which have been delivered, by taking notice of the manner in which fevers are produced by some of the most obvious and common causes -  (99) Has there been a sudden abstraction of heat in the autumn by the shifting of the wind, or a cold night succeeding a warm day, and are these not the sources every year of fevers? - Again has the body been suddenly debilitated by labour or exercise? here the excitement is diminished but the excitability increased, in such a manner that a full meal or an intemperate glass of wine, if taken immediately may excite fever; hence the frequency of fever in persons upon their return from hunting, surveying, long rides, or from a camp life. But how shall we account for the production of fever from the Measles or Small Pox, which attack without predisposing debility; but I answer that the contagions of those diseases, seldom act so as to produce fever, untill the system be first depressed; this is obvious from their always being proceeded by languor, and all the other  (100) symtoms formerly mentioned - thus it is frequently with the plague and yellow fever - even wounds and other local irritants seldom induce fever, before they first produced the symtoms of depression formerly mentioned Let us now proceed to consider how facts accord with the phenomena of fever. I shall divide the phenomena into two kinds I Such as are transients and more or less common to all fevers; then I shall call symtoms of fever - II Such as, being more permanent and fixed, have given rise to certain specific names. These I shall call states of fever, and I Inflammation; it is produced by an effusion of red particles of blood into the serous vessels - This is what Dr Boerhaave called error loci; inflammation is an unit, and [cross out] varied only by its seats and grades; we have analogies in combustion, thus the combustion of punk is like the inflammation of a carbuncle while that of pine wood resembles erysipelas - 2. Secretions, or an effusion from ruptured vessels, X Under this head I include Hydatids, which have been even found in the heart - (101) of the serum of the blood, constituting Dropsies X 3. Secretion of lymph and fibrin, forming a membrane, which adheres to certain surfaces of the body 4. Secretion of pus, sloughs, and of a black matter, which, when in the stomach is called black vomit 5 An effusion by rupture, or a congestion of all tho component parts of the blood 6. Gangrene from the death of the blood vessels 7. Rupture of blood vessels producing hæmorrhage 8 Redness Phlegmon, Pustules Petichiæ on the skin, and tubercles in the lungs, on the liver and bowels 9. Air. How far this product of diseased action in the blood vessels may extend to every part of the body, I am not prepared to say 10. Scirrhus, Cartilage and bone 11. Calcareous and other earthy matters 12. Death - The two extremes of Morbid excitement seem to meet in a point, for low typhus fever sometimes produces death without any mark of disease also - (102) All these effects of fever are different, according to its grade, Dr Blane says fevers are rarely inflamatory in the west indies, that is, they pass rapidly from simple morbid excitement to congestion, hæmorrhage gangrene and death. This remark is confirmed by Dr Dalzelle, who says, the Pneumony in the negroes of the french west indies, rarely appears in any other form but that of notha, from the arteries in the lungs being too much stimulated to produce common inflamation; but such is the force of Morbid excitement in hot climates, that it sometimes suddenly leaks over all its intermediate effects and discovers itself only in death; this appears to have taken place in the cases at vera Crux, mentioned by Baron Humboldt To the first class of the states of fever belongs 1 The Malignant - It constitutes the highest and [cross out] worse grade of morbid diathesis; it is known by attacking frequently without a chilly fit by coma, a depressed slow and intermitting  (103) pulse, and sometimes by the absence of pain, and with a natural temperature or coldness of the skin; It occurs in the plague yellow fever gout, Small Pox Measles, in the hydrophobia, and after taking opium, and other stimulating substances 2. Gangrenous State of fever - this includes the intestinal state of fever 3. Synochus fortis - this state of fever is know by a full quick and round pulse, without tention; it occurs in the autumnal fever, colic and gout 4, Synocha; it is known by a quick frequent and tense pulse; it constitutes the common inflammatory fever. 5. Synochula; known by a small - but tense and quick pulse; it occurs in chronic Rheumatism and pulmonary Consumption 6. Synochoid; here the pulse inclines to the state of syncocha - 7 Synochus mitis, or the mild bilious, or intermitting  (104) intermitting state of fever 8. The Typhus state of fever; known by a weak and frequent pulse; it occurs generally in the form of jail or hospital fever. 9. The Typhoid, Hectic or Puerperal state of fever 10 The Hectic state of fever differs from all other states of fever, by the want of regularity in its paroxysms. It occurs in pulmonary consumption, some cases of Lues, of Scrofula and of Gout. The force of the pulse is occasionally Synochoid, Typhoid and Typhus - 11. The next state of fever is the remitting and intermitting, which is common to all other states of fever 12. Febricula; it is that state of fever in which the morbid actions is so feeble as [cross out] scarcely to be perceptible; it is known in america by the name of "Inward Fever" X He considers fever in its forming state as a sacred thing, not to be attacked by remedies - (105) The states of fever already mentioned, must only be considered as simply, primary; but these again by combining their grades, produce an endless variety of subordinate forms - Of the Remedies for preventing the formation of Fever - We now proceed to the remedies for removing the predisposing causes of [cross out] fever - and here we beg that the nosologist will stand back; he takes no cognizance of a disease in its forming state; X he only prescribes for the disease, when at its acmé ; but we must try to visit our patients out of bed - Premonitory Signs of Fever - These are 1. Elevated excitement 2. Debility from action or abstraction 3. Depression  (106) 1. Elevated excitement generally takes place in the diseases of Children; it shews itself in the hair standing on end; it is known by a frequent full but not morbid pulse, by wakefulness or else only partial sleep, natural dreams, by red or yellow eyes, by a burning sensation in the mouth after taking pepper or wine by a smell like hepar Sulphuris upon rubbing the hands together by colours like the rainbow, constantly passing before the eyes, by the breaking out or drying up, of old sores, by a hot breath, by a cessation of customary pain, by our taking less of our usual food, or less of stimulants, as of Coffee or Tobacco; I know a gentleman who could tell when he was in this predisposed state by his Tobacco not imparting its wonted agreeable stimulus; it is also indicated by an unusual discharge of urine, as well as by great activity of body and vivacity of mind: more or less of these symtoms  (107) preceed diseases of great morbid excitement chiefly, as the yellow fever and plague - The remedies for removing this kind of predisposition [cross out] to fever are Rut, Purges, Abstinence, and sometimes the loss of a few oz of blood; hence it is common to bleed Soldiers by regiments, when they arrive in the west indies; it was removed in this way in Virginia in 1741 according to Dr Mitchel; much blood must not be taken: discharges from issues and blisters have removed this predisposing elevated excitements. 2. The second premonitory sign of fever is debility - it is indicated, by fatigue from the least motion or it exercise, great desire for rest; Children shew it by requesting to be taken into their mother's laps - The remedies for removing this predisposition to fever, are rest, a little warm Tea, pediluvium little X [cross out] In short, the only way to conquer!!! a fever in its forming state, is to submit to its - (100) little study, gentle purgatives, cheerful society X and sometimes the loss of a few oz of blood - 3. The third premonitory sign of fever is depression; it is indicated by weakness of the limbs, inability to stand or walk without pain or a sense of fatigue, by a dry, cool, or cold skin, by lassitude yawning and some pain; by chilliness and a shrinking of the hands and face, and by a weak and quick pulse - The remedies for removing this predisposition, are a cessation from exercises study and labour; I have seen the yellow fever prevented by this means; thus by going to bed with out cloths on, and by taking the precaution not to move, we may prevent the tending, of this predisposition [cross out] to end [cross out] in fever; but should you attempt to remove your cloaths or stir, the fever would be immediately induced; * other remedies are fasting or abstinence, gentle stimulants, X wine whey, 10 drops of Laudanum with a few drops of Hawthorn - I have said gentle stimuli, since they are alone suited to depression, which is always attended with accumulated excitability - * But the business must be of such a kind as only to stimulate the mind gently - (109) stimulants, such as the pediluvium, the warm bath, or a warm bed *, also diluting drinks, such as chamomile and Sage teas X when you make use of these preventives, it may be necessary to give a salt herring to produce thirst - Then predisposing causes of fever are obviated by business and employment; Dr Cullen says prevented * Dr Lind prevented this predisposing depression, by putting persons so predisposed on board of ship, and sending then some distance from the shore; here the gentle stimulus of the sea air removed their predisposition; removal to the country has had the same effect; as also gentle evacuations used near the accession of the fever, as lenient purges and gentle vomits; Dr William Brown speaks in high terms of a remedy something of this kind, in which [cross out] were combined the cathartic, emetic, and Sudorific powers; it was used by a naval X There should be excited by diluting drinks which do not stimulate much - X The jail Fever in this way - (110) Surgeon, who called it his Thunderbolt, other remedies are bleeding, and sweats X Sir John Pringle has prevented it in this way, inducing [cross out] a perspiration by wine whey and the spirit of harts horn; also cold air and water, of this I can speak with confidence, as I know it from the experiment upon myself, and lastly Blisters to the head, on the authority of Dr Lind; he says he has prevented X Thus I have mentioned the symtoms and manner of obviating the three promonitory signs of fever, but it must be remembered that they may be blended; we cannot expect order in the action of debilitated nature; besides, sometimes, a little morbid action is present; different systems will have different degrees of excitements; thus the head may be excited the muscles may be weak, and the blood vessels prostrated. But before I leave the consideration of X Dr Hillary was of this opinion; A It must be recollected that every paroxysm of an intermittent fever, is a complete fever of itself. B Here are the [cross out] exceptions to this rule (111) the remedies to prevent the forming state of fever, let me press upon you a sense of its immense importance, so much so, as in a great measure to destroy the mortality of the plague Of the Means for extinguishing Fever It has been a question, whether we can be said to cure a fever, or only to conduct the system safe through its course; Dr Cleghorne rejected the idea of curing a fever of warm climates X a thing which he conceived impossible; thus the intermitting fever is not cured by bark, it only prevents its return by removing predisposing debility; A the opinion is further favoured by the analogies of Small Pox Measles and whooping cough; but there are some exceptions, as 1 B - Fevers have been cured by great hamorrhages from the nose as well as from the after bleeding; Dr Moseley says the same happens, X This practice I was induced to adopt from observing that the yellow fevers, for one year, fell upon the stomach and bowels curing itself by puking and purging; this was irritating the tendency of nature - (112) in the west indies, where patients with fever have been known to wake up perfectly free from disease in a [cross out] bath of their own blood - yellow fever has been cured after 4 or 5 days by bringing on an artificial Colera [cross out] Morbus X 2. Fevers have been cured by sweats, but Pringle denies this; at least it is not so safe as curing by profuse bleeding, or inducing an artificial Colera Morbus - 3. They have been cured by copious blood lettings - 4. They have been cured by a strong dose of opium, as happened in two instances in this city - during the yellow fever, the one in which the opium was given by mistake, and the other in which the Physician had mistaken the disease; in both cases the patient slept profoundly for 36 hours, and awoke perfectly cured - 5 - Large doses of bark have cured fevers, but this remedy acts by oppressing and prostrating A And perhaps contributed to the fatal issue of the disease - (113) the system, and is pernicious, as it invariably causes dreadfull congestions of viscera - 6 Fevers have been cured by large draughs of wine - 7. The pediluvium has cured them, but of this I have no experience, but on the contrary have seen it increase fever and delirium A 8 Affusion of cold water, in this way Dr Currie has cured yellow fever but not after the 5th day - 9 Banguios, an indian remedy, consisting in first sweating the body profusely with vapour, and then dashing into very cold water; the Russians use a similar remedy for their health - 10 Overstretching after the manner of the Indians, as by hanging by the arm from a tree - 11 - By Frictions; thus Capt. Cook [cross out] was cured of a Rheumatism - in one of the Friendly Islands, in one hour. 12 Violent exercise or labour; thus a Scotch Physician cured his patients by tying them to his plow X or it was produced & in an Indian constitutions or one equally robust - (114) 13th and lastly Fevers have been cured by sudden emotions, as anger, joy, grief, terror, instances have [cross out] been known of persons being cured of malignant fevers by the terror created by a storm [cross out] or battle - It is very certain that innumerable persons have recovered from fever, but not until these fevers had run their course, we may think we have strangled a fever in one day, but here we are not certain [cross out] that it [cross out] was not a fever of one paroxysm; but even though the fever be not ephemeral; or one which would have terminated in two or three days, yet it must (if strangled) be either very feeble or of a centrifugal action X for we see the Indians never survive their remedy for fever, after being inervated by their intercourse with civilized nations; it is always best, as I said before, to lift up the latch than to burst open the door of a disease, except in very urgent cases - A and again when the storm subsides, he gradually expands his sails to be moderately stimulated by the gentle stimulus of mild breezes - The first division of Sedatives into A Evacuants 1. By the sudden suppression of the natural evacuations; them by producing plethora - (115) But there is an erroneous opinion prevalent in England, that fevers will cure themselves, or be removed by the assistance of Jame's powders and pediluvium - but our fevers are a direct evidence of the fallacy of this opinion; we must in our fevers unload the system, or if I may be allowed the expression; we must throw part of the cargo overboard, as a skillful mariner would do in a storm A Of the Remedies for fevers - Then remedies are of two kinds, sedative and stimulating - Sedatives are indicated in the malignant, synochus fortis, synocha, synochula and synochoid state of fever; the most important sedative is the evacuant, I bloodletting - [cross out] It is indicated 2. In habits subject to fever - 3 By the first symtoms of fevers, [cross out] [cross out] such as sleepiness with a weak pulse, or delirium X This conjecture is string thread by the spleen being found much less, upon direction than formerly, since bloodletting has been used more freely in all diseases: this is a remark of Dr Wistar - It prevents hemorrhagies, induces sleep; prevents acute diseases terminating in incurable chronic diseases; it is less terrible than other remedies; it prepares for the use of bark and wine - (116) delirium with a throbbing one - 5 By a tendency to rupture in the blood vessels, when the spleen is full and very small; the lancet here perform the vicarious office of the spleen X 8. It is indicated in most instances from its immense advantages; it is a stimulant when it removes prostration. 2. it often strengthens when it removes depression. 3. it lessens pain 4. it checks costiveness nausea and vomitting - 5 - it renders the system susceptible of a salivation, it removes blackness of the tongue, as well as chilliness; it disposes to sweats, before which, if diluent drinks had been given it would only have added to the plethora; it checks diarrhœa; it cures a fever before it takes on the gangrenous grade, hence the cause of the different opinions given by Dr Sydenham and Dr Morton, both practitioners in London of the same fever, as Dr Morton X Therple those of old people arises from their taking little exercise, therefore sweating little, from their costiveness, from their eating very much - (117) from his aversion to bloodletting, allowed the fever to put on the gangrenous form; lastly bloodletting prepares the system for taking bark - Bloodletting has been thought highly improper when resorted to in warm weather, or for the diseases of those born in hot climates; to remove this error I need only say that Galen bled in the plague in a hot climate, and Sydenham, Cleghorne and Moseley, have all done the same. Bloodletting has been objected to in great apparent weakness; but here bloodletting will make us stronger - Infancy and childhood has been thought an objection to bloodletting; so far from it, they require more bleeding than adults in the same disease, from their natural plethora; X then blood is very sizey Old age has been thought an [cross out] objection; but on the contrary they require more X If other [cross out] symptoms call for it, such as the pulse - X Neither are abscesses nor sore breasts objections; The length of the fever has been supposed an objection; but this is not the case; neither are tremours to forbid it; the patient getting worse after the bleeding, is no objection but an indication that you have not bled enough!!!! - (118) bleeding in the same disease. The time of menstruation was supposed to forbid it, but it really calls for more bleeding; it is also supposed improper in pregnancy, but this opinion is entirely erroneous, for so far from being forbidden, you must, in order to produce the same effects, as [cross out] when the system [cross out] is not in that state, take double the quantity of blood - Fainting after bleeding was supposed to forbid a repetition; but the fact is, this will go off after two or three bleedings; neither do cold feet forbid it, as was formerly supposed; nor sweat X nor dissolved blood, but on the other hand, proves its utmost necessity; neither [cross out] is, a great proportion of serum, great length of a fever; nor petechiæ, any objection to bloodletting X you may bleed after the 5th day in a Pleurisy - II Emetics - The second evacuant Sedative are Emetics; A We cannot regulate their effect; they will either vomit too much or too little Senna may be given ℥ss - in half a pint of boiling water, brown Sugar may be added, and a little orange peel - (119) but these are not efficacious in fevers unless repeated 3 or 4 times; A they are not to be used in Pregnancy, but are extremely safe for Children; the preparations of antimony are to be preferred, except in Dysentery; they are best in the the begining of fevers especially if they [cross out] arise from hoino miasmata - II Purges The next evacuant are purges; they are indicated in fevers of high morbid action; they prevent the stimulus of fæces and their pressure on the descending aorta; they remove acrid bile; they discharge chyle, and lastly they render [cross out] the bowels weak, thereby inviting the disease to pass out [cross out] through them - Purges are either lenient, [cross out] active or drastic; some purges act as diluents, as such, the Sul.te of Soda and cream of Tartar are excellent; Sulphur acts chiefly on the lower bowels, but Calomel and Jalap, like chimney sweeps,  (120) clean them from top to bottom; In fevers with paroxysms, purges should be given in the internal, or near the end of the paroxysm, because then the system is generally weak, and the excitability of the bowels accumulated, and therefore will be acted upon by a much less purge, Dr Sydenham forbids purges at the crisis of a fever, but this advice arose from his belief in morbific matter: our patients often ask when we [cross out] prescribe bloodletting, why not substitute a purge; the reason is this, a purge cannot be given at all times, but bloodletting is safe whether performed in a paroxysm or an intermissions - In Bilious fevers, it will be very necessary to inquire into the state of our patient's stools, with respect to their colour and smell; our patients often tell us they have  (121) been well purged; that they have had so many stools, but if you inquire into their colour and smell, the answer is generally "quite natural"; let me assure you gentlemen that in such a case you have done no good; you have only emptied the lower [cross out] bowels - hence you must continue your purges until you probluce purges of a greenish or blackish tinge, and, then only are you certain you have cleared the upper bowels - IV Clysters - These are the next evacuant sedative that may be used in fevers; they are good to evacuate the hardened fœces in the rectum, which sometimes exists there, although the patient may have liquid stools; they remove sickness and vomiting, and relieve the aorta, kidnies liver bladder, and upon the whole are less offensive to patients than purges - Dr Sydenham records a fever in which Clysters were useful, but purges afforded no A But it will as by cure the forming state of the plague - (122) relief; the reason of this was, that a purge act, generally 4 or 5 times, whereas as clyster produces but one evacuation, and further, there is no occasion in giving a clyster for the patient to rise from bed They may act by stimulating, and cure fever by translating excitement to the rectum, we know that piles sometimes have that effect, if Clysters disagree, suppositories may be resorted to - V Suppositories The most usual are Salt, soap, wax, and Salt and water; this last is particularly useful for Children, in their fevers - VI Sweating Medicines - These are either external or internal - the external are 1 - Blankets, used after the manner of Dr Sydenham, 2 - a warming fan, moved slowly up and down the patient, 3. Dr Darwin advises putting the head under the cloaths, thereby preventing the warm air to escape, 4 - Hot oil, supposed at one time to be an antidote to the plague. A of all these different methods, the 1st the 2nd, the 6th and the 8th are only to be used - (123) 5 - Warm bath, 6 - The application of flannel dipped in hot water, 7 - The vapour bath, 8 - Bricks, and bottles filled with warm water, and wrapped in flannel; applied to the feet; but these external sweating applications should be used only in fevers of great morbid action - The internal sweating medicines are 1 Nausious, such as small doses of of Tartar Emetic, antimonial wine, and Ipecacuanha; this class of medicines was [cross out] introduced by Dr Cullen; they act by the inverse sympathy between the skin and Stomach - 2 Diluent drinks; this remedy is good in the forming, but not the formed state of fever; in the latter state, they should only be taken to allay thirst; 3 - There are a certain set of medicines called sweating medicines, as Dover's powders, Virginia snake soot, valerian &c - 1 I object [cross out] to sweating medicines as a means of curing fever, because [cross out] sweaths cannot be excited  (124) at pleasure, and never when this body is above 100 deg. of heat [illegible] Because we cannot always [cross out] proportion the degree of sweating to that which would be useful to the patient - 3. Because we cannot always stop them, when we know them to be excessive, now this objection does not apply to bloodletting - 4. Because they are disagreeable - But notwithstanding they are undoubtedly sometimes highly proper - as when, 1. we are see nature endeavouring to relieve herself in that way. 2. when experience has proved them to be useful to our patient, thus I saw a case of gout in the stomach and [cross out] bowels relieved only by sweating. VII Siallagogues - Then remedies are useful in fevers of high morbid action; in fevers which run their course in 4 or 5 days, they are entirely forbidden, or the Mercury has not time to reach the [cross out] month; Dr Jackson says, he never salivated with a dry or torpid skin; when the mercury is applied by friction They must also be used even before the pulse has descended to the blistering point when there is great determination to the brain. (125) it is hurtful as the friction increases the fever; when it is necessary, it is best to apply the mercury to the arm pits - VIII Blisters - Blisters are only proper when the pulse has descended to the typhoid grade of action, which I have called the blistering point; before that point they stimulate too much, and below it, will produce no effects; yet when the action of a fever is very high, and you fear black vomiting, you must use them, even though they should produce mortification of the wrists; when the effect of a blister is to lessen the frequency of the pulse, and also when they produce Strangury, it is always a good sign - B. Remedies abstracting the Stimulus of Heat - This is the second grand decision of  (126) Sedatives, used in the care of fever, these are cold in the forms of air, water and ice - Air should never be applied at a less temperature than 22 deg. and at the same time equally Dr Sydenham made her patients sit up in bed to guard against unequal depression; Dr Wallace mentions a man who was drunk when he lay down, and yet sober when sitting; so it is with headach, we very often do not feel it untill we lie down, and we often wake with headach from the same cause, which is the tendency of blood to the brain in these cases; this tendency exists in a great degree in fevers, but cannot be relieved [cross out] by posture, [cross out] and then as a substitute it is necessary to apply cold water to the head; water has several advantages over cold air, besides its being more readily procured; Mahomet, who died of a Color  (127) Mordius, called out to his wife to throw water on him; Bruce the celebrated traveller in Africa mentioned that a nation cured inflammatory fevers, by constantly keeping the patient's matrass wet. There are three ways of using cold water; by affusion, infusion, and ablution - I affusion - This acts, first, by stimulating from the manner of application, which is generally by buckets of water being dashed over the patient - and - 2 - By its indirect effect in producing a healthy action. It is extremely prejudicial to the system in yellow fever, if it be not previously prepared for it by copious depletion; when used without these precautions, its effects fall upon the bowels, and in many cases bring on death - I object to this method of using cold X with more safety and certainty (128) water 1. Because it supposes the cause of fever to be a spasm in the capillary vessels which terminate in the skin - 2. Because it requires such nice discernment to discover the proper time for, and the quantity of the remedy, for there is a point to indicate water as well as sleep; to do this, would require the constant attendance of a Physician - 3 - Because it is disagreeable, and attended with danger in the winter - 4 - Because the visceral congestions and inflammations which take place generally in the autumnal fevers forbid it - 5 - Because all the advantages are to be obtained by depletion * even the greatest advocates for water as a remedy in fever allow that it does not shorten, but only lessens the force of the paroxysms of fever; why make a patient in a fever get out of bed to be drenched to lessen the paroxysms, rather than effect the  (129) same end by the safe and easy operation of bloodletting, or cold air; but hereafter I shall mention its use in a contrary state of the system - II Infusion The 2nd mode of using cold water is by infusion; it is, inserting the whole body into water at the same time, and thereby obtaining Sedative effects; we have an account if a man in London, curing himself of the plague by dashing into, and swimming over the Thames; in Dr McLane mentions a similar instance of a cure from a malignant fever by jumping into the sea from a ship - The same objections may be made to this method of using cold water, as was made to affusion; there are few patients that would submit to it; it may be beneficial if used as Dr _ directs; that is, by placing your patient up to his neck in water and compelling him to make every exertion with his limbs,  (130) and thus wear down his excitability, but why this parade; why not take down the system at once by bleeding - III. Ablution This is nothing but rubbing the body with wet cloths, every two hours or oftener; it lessens the frequency of the pulse diminishes the heat of the skin often produces sweat, [cross out] relieves pain, and often induces sleep; it is safe in as much as it does not require the patient rise out of bed, nor does it require many attendants, ablutions of the feet and hands often produce the same effect and a bladder partially filled with water and applied to the head is often very useful in fevers, when there is an obvious determination of blood to that part; you must sometimes use ice especially in your applications to the head, it being a very insensible part; I know that ablutions are good from my own experience in 1793 in the yellow fever, when I cured In favour of this method of abstracting heat from the body. I may sensation that it is not incompatible with the delicacy of Females, nor have our male patients to discharge the female nurses. (131) the forming stage of that disease by ablutions, 1st of the hands, then of the feet, and so on gradually; I conceive the skin, the blood vessels and the nerves to be an emit and when anything is applied to one of these systems it is felt by the other two; here I may mention, that the hands and face are exceptions, for their sympathy with the rest of the body is dissevered by habits. X Dr Currie thinks that all cold when applied partially is hurtful, but I disagree with him; he says it is forbidden in partial or general sweats but I have not found it so; on account of the universal sympathy between the skin and lungs, cold is always hurtful in complaints of that organ - Cold when applied by ablution is good in bilious fevers; it lessens heat, and instead of its effects falling in the viscera as [cross out] those of affusion are apt to do it creates a pleasant centrifugal tendency. Dr Cummings says, spirits when applied to the skin is productive of considerable advantages it produces X This was observed by Dr Fuller - (132) considerable cold by its rapid evaporation, but this remedy, generally speaking, is too expensive. [cross out] Abstinence - This is another sedative precaution used in fevers; in them, all kinds of stimulating food should be forbidden, such as butter milk, meat broths, malt liquors and ardent spirits; and weak tea and Coffee, Sago, oatmeal or corn gruel, rice, tapioca; arrowroot gruel, Jalap made pleasant by lime juice and Sugar, potatoe tea, or asparagus broth, roasted apples, broth of the water of wheat bread, or potatoe broth, may be taken; in inflammatory fevers light and Company should be excluded, for the pulse even in health is lessened as strokes in a minute by the abstraction of light X The Abstraction of Invigorating Passions - This is a very important consideration in fever; our patients should not suffer under the effects of any stimulating passion; we should even call in the aid of the Sedative fear, to counteract them -  (133) The stimulus of motion should be abstracted by rest; though Dr Jackson advises gestation, but he alludes to the synochus mitis and Typhus fevers; The stimulus of thirst must be removed, and acrimony, generated by heat and abstinence should be washed out: the proper basis of all diluents is water; these diluents may be the following, an apple dried, green, or roasted to a pint of water with some sugar to make it palatable; tamarinds, Currant Jelly, balm tea, Lemonade, toast tea, toast water, blackberry jelly, grape jelly, or dried cherries; I have mentioned a number of diluents, since they should be varied, to prevent the patient getting tired of them; they should always be made as pleasant as possible; I shall hereafter mention many more diluents adapted to other states of fever. It has been a question at what temperature then drinks should be taken; some say, in a cold state; [cross out] but [cross out] they should not be either cold or hot, Dr Currie says, that when water is proper for X Of its sedative effects - (134) the skin, it cannot do harm in the stomach, but I differ from him, for we know that sudden death is often produced by taking cold water into the stomach; but Dr Currie accounts for it by saying that the stomach is debilitated in all such cases; so far from this being the case, those who generally suffer from cold water, are persons who are highly excited by labour - I shall account for it by shewing that different parts of the body are more or less susceptible of the impression of cold water in the following order, the stomach most susceptible X and next different parts of the skin; of the skin, the hands!!! and feet!!!, arm pits and back are most sensible, then comes the bowels, and lastly the head, which is least sensible, hence the necessity of using ice to that part; Dr Currie further says, that cold water always acts as a stimulant, and yet he says it produces sudden death by acting on the debility the stomach; now one would suppose that water in such a [cross out] case, so far from producing death, would by its Stimulant quality, renovate a person - X That is between 86 to 96 degrees (135) Having rejected both hot and cold, I prefer tepid diluents * at this temperature they allay most certainly, the thirst; disputes have arisen as to the quality of diluents. The spanish Physicians, Dr Cleghorne tells us, invariably prohibit drink in the forming state of fever; this is true, but it might be added, "in the last stage also"; if our patient be not satisfied by a pint of water, then it will be necessary to make use of such substances as will allay thirst, without increasing the fluids of the body; this may be done by chewing an apple, [cross out] sucking an orange or washing the mouth with flaxseed tea or a solution of Gum Arabic; I think it probable, salt would have the same effect, we know it allays the thirst of many domestic animals, probably it acts by inviting Saliva to the mouth, and producing an excitement transcending the stimulus of thirst; in the intense heat of 130 deg. in 1804, those Soldiers, of Sir David Baird's army in Africa, who only washed  (136) their mouths were least affected by the heat - C Translating Sedatives The third grand division of Sedatives to be used in fever are such as divert local morbid excitement, congestion, inflammation and Serous effusion from part, which are essential to life in the first degree, to such as are less essential to it. These are all such as were mentioned under the head of evacuants, together with the following - 1 Neutral Salts - There are nitre, which acts by inviting action from the blood vessels to the stomach; but it is seldom retained by it in gouty or bilious fevers. 2. The Sulphates of Soda, potassa and magnesia 3. The tartrate of potassa which is good in bilious fevers, and lastly the acetate of ammonia; useful in nausea - 2. Certain preparations of Antimony; these are very useful in fever; of all of these I prefer the Tartrate of potassa - and - antimony; it is very safe; and although it is not always of the same strength, Dr Rush used to call it his antimonial powder with calomel (137) yet it is less objectionable than any other preparation of antimony; it translates the disease to the skin, 1/8 of a grain of the tartrate of potassa antimony, to 10 or 12 grains of the nitrate of potassa with the addition of 1/2 a grain of the promuriate of Mercury, when the disease has a bilious tendency (and taken every two hours), constitutes the antimonial powder - 3. Seneka snake root has a centrifugal effects, and is good in the synochus state of fever; but particularly in Pneumonia, Rheumatism, and cynanche Trachealis - 4. Sugar of Lead is recommended in fevers to lessen the frequency of the pulse, but it produced Colic so often, I had to give it up - 5. Digitalis has been given to lessen the pregnancy of the pulse in the hydropic and pulmonic states of fever, but with its I have had little success; it is said only to be useful, when the pulse is full and tense, but in this case prefer bloodletting A By increasing the action of the blood vessels and giving a centripetal tendency to the blood. B It has [cross out] produced ecchymosis all over the skin - C But it must not be continued too long otherwise it will become exquisitely painful and distressing - There being all the fevers above the par of action (138) 6 Other Remedies - Sweet oil has done good in fevers of great Morbid action when applied with a feather, for if applied [cross out] by friction, it increases the fever, A but it is hurtful in the delicate state of the skin in gangrenous and petechial fevers. B nitre and vinegar, when applied to the body in fever is good, as also tight ligatures to prevent the return of the blood to the viscera. Dr Stohl of Vienna says wakefulness weakens high fevers, by preventing delirium, for, says he, sleep is a tendency to delirium; C but I shall say hereafter that sleep removes the delirium of fevers of weak morbid action - The remedies already mentioned are those only which are proper in synochus fortis, synochus Mitis, and all the intermediate grades - D The Typhoid State of fever - In this state of fever, there is generally a Synochus or a synocha action, and occasionally a Typhus; it takes place in the puerparal fever, and the Scarlitina Anginosa; it often takes on the pulse In this fever the pulse is quick has almost lost its jerking; the skin is generally dry and cool but sometimes partially moist and hot; the urine is pale; the hearing dull; the body is affected with tremours; the tongue falters in speaking; the intellect is dull - (139) of other forms of fever not mentioned; its symtoms are wakefulness or not much sleep, natural dreams, no chills; the pulse differs from a natural one, in having a jerk; the patients have also dull perceptions, and the tongue is either very moist or very dry, this state of fever is called by Dr Butler the slow state of nervous fever - The Typhus State of Fever Towards the close of this fever, there takes place an involuntary discharge of faces, and urine unaltering and a [cross out] [cross out] delirium, called by Dr Cullen, delirium mite to distinguish it from the ferox; Dr Butler calls this the low state of nervous fever; then distinctions are very proper - Vulgar Errors - I shall mention a few vulgar errors with respect to these fevers - 1- They are suppose to be nervous; but this is not so; their action is seated primarily in the  (140) blood vessels, while the nerves are only affected secondarily; in fact they affect the brain and muscles more than they do the nerves; and if we agree to call them by any other name than fevers of the blood vessels, let us adopt the term cephalic or muscular 2 - They have been supposed to be the effect of immoderate depletion; but nothing could be further from the truth; for they are sometimes epidemic, and in some countries, endemic - 3 It has been supposed that the Typhus fever proceeded from miasmata; but do we not know that the yellow fever sometimes degenerates into this form of fever; I had a case of it in Mr Bell, whose yellow fever, after some continuance, took on this grade, and she died of the black vomit at last; [cross out] Dr Pintard says this was the case with a yellow fever in the west Indies; and further, the bilious, which runs its course now, in 3 - 5 or 7 days, in 1775 ran on to 20 days - 4. It was supposed that the Typhoid and A [cross out] but here I have used vomits in the forming state; I was in the habit in the Revolution of carrying vomits in my pocket and giving them to every soldier who was somewhat unwell - (141) Typhus fevers were always chronic; but I have seen them prove fatal in 3, 5 and 7 days - 5th and lastly, it was supposed that Stimulants should be used in every case; A but I object to stimulants in every case for the following reasons; we have already mentioned that there are two irregularities in the blood vessels, one owing to, their muscular coats, and the other, to the wrong direction if the blood - the latter irregularity exists in the typhoid state of fever, and hence the reason why stimulants may be hurtful, by increasing this wrong direction of the blood; in some cases it will be necessary to draw a few oz of blood but in low habits, and such as have been debilitated by labour it will be improper; should there be any tendency to the head, cupping may be useful; in this fever officers will [cross out] very of often bear the loss of a few oz of blood, but common Soldiers, never; here we have another argument against Nosology,  (142) that the same exciting cause produces two such different effects; then let us exclaim in the language of the Roman Senators; when speaking of Carthage; delenda, delenda est Nosologia Remedies for the Typhoid [cross out] Fever vomits are sometimes used, but, to be useful, they should be repeated frequently; Dr Hamilton recommends purges in the low but not the slow state of nervous fever, but, to be useful, they must be taken every day or every other day; nitre or the antimonial powders are good when the fever is not a form of [cross out] the bilious - Blisters are good they, act by a centrifugal tendency and prevent congestion, by translating excitement from the bowels to the part to which the blister is applied; ablution and perhaps affusion, may be useful; the [cross out] former is best when we wish to reduce the Typhoid to a typhus!!! fever; a salivation has sometimes succeeded, when every other remedy has failed, but it is often very difficult to excite it. Dr Jackson's A By which means you will probably be able to remove it, without breaking down the sides of the Mill race - (143) remedy of gestation might come in here, but it must be used, until the typhoid pulse is nearly subdued - Suppose a Mill race, filled up with dirt and stones; now if we open the gate suddenly, the water would tear away the sides of the race, from its impetus upon the obstruction; therefore we must let the water upon the obstruction by degrees; A to make the application; [cross out] exhibition of gentle stimulants should be used first; and here if the pulse becomes slower and fuller, it will indicate them to be doing good, but if, on the other hand, they should have a contrary effect, you must lay them aside; so, you must watch the pulse narrowly - Remedies for the Typhus Fever here now come to the remedies for the low state of fever, or what Dr Cullen calls the Typhus mitior; here the same remedies are necessary as in the gangrenous state of fever, since the two extremes meet - The prostrate and gangrenous [cross out] fever I included under the typhus state of fever - (144) The term putrid is improper, since no putrifaction can take place in the blood vessels as Dr Seybert proved; in this disease the blood is dissolved, in one case from the excessive in the other, to the defective action of the blood vessels [cross out] upon the blood -  (145) Of Stimulants used in Fever Having finished the consideration of the Sedatives used, in fever, we come next to the Stimulants - Then naturally divide themselves into Internal and External - 1 The Internal Stimuli subdivide themselves into Aliments and medicines; aliments, such as meats and vegetables; Medicines, such as all fermented and distilled - liquors, Volatile alkali, - empyreumatic and aromatic oils, also certain fetid animal and vegetable substances, opium Ether, Bark and Bitters of all kinds, Mercury, Pure air, Oxygen gas, invigorating passions and emotions, and lastly stimulating injections into the bowels - 2. External stimuli are warm water by ablution, and cold water by affusion, Blisters, Cataplasms to the feet and fomentations to the lower limbs, certain applications, calculated to inflame and irritate the skin, Caustics and  (146) scarifications, boiling water, Frictions, light, sound. We shall now say a few words on each of the internal medicine stimuli just mentioned - 1 - Wine - This is a very agreeable stimulant, it contains nourishment, as well as being diluent. Wines are divided into such as are white, as the Madeira, Sherry; Teneriffe, and Sicily wines; such as are red as Port and Claret &c &c. - less of the white wines must be taken; they may be diluted, though they are not very likely to intoxicate when given in the low state of the system; for there is no excitability for [cross out] them to act upon; you may give them in the shape of wine whey; I lost a student in a typhus fever, for want of this remedy; the young man's parents were afraid of his passing into eternity in a fit of intoxication !!! - 2. Malt Liquors - The bitters quality of these makes them stay upon the stomach; from one to three bottle should be taken in a day, of all  (147) kinds of malt liquors, porter is to be preferred; it is even better than wine, wine it affords more nutriment - 3. Ardent Spirits - These should be given to habitual drunkards, or those accustomed to them; but even though your patient be not addicted to them, you may pour down a quantity indicated by his fever, without any fear of begetting a habit of intoxication; so low sometimes are our patients, that they may take a quart of brandy and wine every day with advantage; this was the case with a Lady with the spotted fever in Connecticut; brandy allays thirst - 4 - Volatile Alkali - This remedy is good in doses of about 5 to 10 grains, in the form of a bolus, or with a solution of gum arabic; the fixed alkalies have been very strenuous by recommended by a gentleman of new york, for the purpose of removing the septic acid, which he supposed Mask is generally used in those fevers which are attended with muscular action; but the smell of it is disagreeable and it is a very expensive remedy - (148) supposed to be the cause of the disease; this idea is not new, Silvius supposed a similar acid, [cross out] in a fever at Leyden; but I have no belief in the doctrine - 5- Empyreumatic oils, - Of them I know little; oil of amber is good in curing hickups in doses of from 3 to 10 drops every two hours; but sometimes a hickup will yield to nothing but bleeding - 6 - Aromatic oils - These are the oils of cloves, aniss cinnamon mint &c - Their principal use is to make medicines lie upon the stomach - 7 - Certain fœtid animal and vegetable substances these are Musk Castor, oil of amber, and assafœtida; all of which act upon the nerves; Musk is not so good as either of the others, as it is disagreeable to most patients - 8 Opium - This is an ipse agmen, a host of itself; it acts upon the lymphatics, nerves glands, I am aware that Dr Cullen considered it as a sedative - (149) muscles, brain, mind, stomach, bowels, and skin; hence it may be justly called an universal stimulant; in thus acting upon all the systems, it differs from every other stimulant; thus Bark acts upon the blood vessels, ardent Spirits upon the brain, oil of amber on the muscles, bitters upon the stomach, mercury upon the lymphatic glands, volatile alkali upon the nerves, but opium acts upon the whole of the systems of the body at the same time - Opium may be compared to the Sun, diffusing strength, through our whole system, while other stimulants resemble a lighted candle, whose influence extends no farther than throughout a chamber; its effects upon the arterial system are not so great as those of ardent spirits, but the reason is obvious for while the force of the spirits is concentrated in that one system, the opium is diffused throughout the whole body - A As it disposes blood too powerfully to the brain these producing effusion and afterwards !!! - (150) I was first made acquainted with the efficacy of opium in fevers [cross out] by an accident which happened to a Physician in Maryland, and have been since very much pleased to find that the same remedy, at the same time was made use of, in the same disease, by two eminent Physicians, once resisting in the East, the other in the west Indies - Rules for the exhibition of Opium 1 - Small doses of opium should be given for fear of our overshooting the mark, and stimulating beyond the sleeping point; there are two ways of inducing sleep; one, by raising the system to the sleeping point, and the other, by stimulating to such a degree as to [cross out] depress the system to that point, but this last method is always unsafe A 2. The doses should be increased with the progress of debility; from two to 10 grains The common injection of this kind is a teaspoonful of Laudanum in a gill of water (151) during the day, and 8 at bed time; in Connecticut 1 1/2 grains has been given every hour in the Spotted fever; the failure of this medicine often arises from being administered with too sparing a hand 3. The dose should be increased during the night; the pulse should be watched; if it flag, you must wake your patient to take a dose; otherwise the patient may die in his sleep - 4. Lay it aside when it begins to have no effect from habit, and try other Stimulants; but after an interval resume it. 5. If it should induce headach, or disagree with the Stomach, you must double the dose and give its by injection 6. We should lessen the dose in proportion as our patient recovers; when Opium looses its effect. Ether may be substituted in doses of, from 30 to 60 drops every hour, but it is very volatile; Bark has many advantages, such as durability and diffusibility of Stimulus a julep of Bark - ʒi Mint water ozj Hux Tinc. ʒjss water - ℥VI Laudanum Gutts LX has a better effect than to take the bark in substance, from the prejudices of most patient for they will suppose their Physician has mistaken their disease by giving Bark, which they think, only prefer in Intermittents; the dose of bark may sometimes be increased to ʒVI, but in some cases small doses do better. When the Bark looses its effect, Bitters, willow bark, and a mixture of Coffee X For it acts as a stimulant; at the every time I was using this noble medicine in this disease with great success it was used by two great Physicians, are in the east, the other in the west Indies - A To have the effect of purifying the air - (152) and bark in a pint of boiling water, are good substitutes, it was in this last way, Assalini used it; the success of these medicines is owing to the variableness of the ratio between the excitement and excitability 11. Mercury - It is an excellent stimulant in fever, it acts by inducing a Salivation; its efficacy was discovered by accident, but it is of use even if it do not Salivate; X Salivation is necessary in yellow fever, when bleeding is forbidden by the pulse; when the smell of the Mercury is offensive its use is forbidden. Ammonia Ardent Spirits and Ether act upon the nose; bark Laudanum, large quantities of water and Sp. of Turpentine act upon the bowels - 12. Pure Air - In this state of fever cold air is prejudicial, which cool air is beneficial - Dr Lind has prevented the formation of fever by sending his predisposed patients on ship board, some distance from the shore; here the sea air removed the predisposition; but when pure air cannot be obtained by change of situation, it should be done artificially, as by a large fire, in a large room, A by placing the patients on ground floor, or in Mud houses, for it is well known that mud will neither retain nor propagate A at least we have this on the authority of Count Saxe - A All died who laid in beds near walls, all recovered whose beds were out into the middle of the room - (153) propagate contagion; A thus during the yellow fevers it was observed that men employed in digging cellars, and the Scavengers were less liable to take the disease; and it is well known that Dogs when bitten, bury the wounded part. those people who lived in smoky huts were exempt from [cross out] a disease which raged in - The air of a room may be kept purely by a ventilator in the ceiling and floor, 3rd. By the deflagrating nitre or - pouring Sulphuric acid upon nitre or common Salt, when either nitrous gas or muriatic acid is given off - 4th by removing the beds to the middle of the room, and never allowing them to have curtains: Dr Baird sly prevented the spreading of a dysentery by putting the bunks in the middle of the room. A 5th visitors friends or nurses should never sits on the bed side, for the lungs in fever, are often very sensible, and require every possible portion of oxygen; I knew a man, whose lungs were so sensible, as to enable him to tell, with his curtains drawn, whether there were two persons in [cross out] his room. 6th. The excrement should be evacuated into a pot half filled with water and removed immediately; in this way the fœtid odour of the stools is suffocated - for this important A Sir john Pringle has remarked that british Soldiers who were sick in the upper stories of hospitals had a greater chance of recovering - The same has been remarked in St Kitts - Conversation upon one subject has often prevented delirium - (154) important advise, we are indebted to Dr Clarke of New Castle 7. the sheets and body linen should be changed every day and the body of the patient, as well as the floor of his chamber should be washed - sometimes vinegar is used; but this vegetable acid is very liable to putrify; ardent Spirits should be preferred. A These matters are very useful, as it prevents nurses and attendants from catching the disease. The importance of Cleanliness may be drawn from the following fact communicated by Dr Bond: [cross out] 12 persons with Typhus were taken out of a ship which arrived here; they [cross out] were all attended in clean beds and rooms, not crowded; these men all recovered; 14 other men in the same disease, were taken out of the same ship, at the same time; but in consequence of the want of attention to cleanliness they all died. 9th 13. Oxygen gas - This gas has been said to be very useful in fevers, but I can say nothing from my own experience; it is too expensive for common purposes, - 14. Invigorating passions and Emotions. Terrour has sometimes cured a typhus fever, of this, we have many instances in the attempt of the americans to avoid the British  (155) army; Love has had the same effect in a young Lady, [cross out] whom a typhus fever was created from an attachment to a young gentleman to marry whom, her father refused permission; the family thought she was dying, when her only request was to see the gentleman, the effect was instantaneous, far from that moment she recovered; the appearance of long absent relations, public or private news has sometimes had the same effect; but these remedies should only be employed in the crisis of fevers; but there is one passion that can never do harm; it is hope; we should console our patients by telling them we have known recoveries from a much lower state; at this time all gloomy visitors should be interdicted, we should also prevent their knowledge of disagreeable or distressing news, and, even upon their inquiries, give them evasive answers Other Stimulants proper in fevers are aliments; these are Sage, Panada, Arrow Root, Saloop - Bread and Milk, Musk, Tapioca, Rice, 3 Potatoes and one Onion made into a broth -  (156) According to their nutritious qualities, aliments may be arranged in the following order, 1st oisters, fish, soft-boiled eggs, cheeze, wild fowl, Poultry, [cross out] beefstakes, Ham, many prejudices exist against aliments in fever, but they do good in three ways, 1 from the gratification of taste; [cross out] for a desire for food generally springs up about the 14 or 15 day of this state of fever; 2. By the new stimulus which it affords the whole system through the medium of the stomach, 3. Because it generates blood; for about the 14 or 15th day, the blood vessels become very empty - Rules for giving aliment in Fever - 1. The quality should not be regulated by the appetite, it sometimes craving more, and at other times [cross out] less, than is beneficial to the system. - 2. The times of taking aliment should be frequent and in some instances, it should be [cross out] taken in small quantities, every hour during the day and night; but in all cases the food should be varied - Of External Stimulants Proper in Fever 1 Heat - This may be applied in the dry form, as by bottles filled with warm water, hot salt, oats, or sand, their application is the more necessary when the heat of body A For the system is below the par of their action - (157) is below par - 2. applications suited to inflame the skin; These are the flesh brush, and frictions with the dry hand, as also pinching the skin and flesh; in this way a Student of our hospital kept himself from dying a whole night; also a strong solution of Salt [cross out], a decoction of bitter and aromatic herbs, with vinegar and water [cross out] hot spirit, soap liniment [cross out] or Sp. of Turpentine applied by friction - These applications should be made to the temples, arm-pits, stomach, and especially about the navel and lower extremities; volatile applications may be retained by flannels - cures have been made by liquid bark and brandy - 3rd. Blisters, Cataplasms &c. These are important; though Blisters are apt to produce mortification on the extremities, A yet they are excellent remedies to remove delirium; cataplasms may be arranged in the following order, according to their strength 1st flour and vinegar, next salt and vinegar, mixed with flour, and afterwards Onions, then garlic bruised, and applied to the feet stitched up in a bag, next mustard and wheat or [cross out] rye flour, and lastly mustard by itself - Sir John Pringle says applications to the feet do no good unless applied for [cross out]  (158) an hour, 4th. Caustics and Scarifications. These are good in Typhus fever; a gentleman was so much indebted for his life to a caustic issue on his neck that he intended to call his next ship caustic. 5th Boiling water; This is excellent stimulant should be applied near the heart or head to prevent mortification. 6th. gradual depletion of blood drop by drop is often found beneficial; I am disposed to [cross out] think highly this remedy, as well as the application of Caustic from the effects of Spontaneous hæmorrhage [cross out], and sores upon, the gums about the 5th day in yellow fever - 7th. Light is a very powerful stimulant - 8th found is sometimes very useful; Soldiers are able to walk farther and longer by this Stimulus of martial music; it is the same with horses in a team; but we have facts as well as analogies; Dr Dalzel says, a person in Cayenne was recovered by the firing of Cannon, and Dr Physick had a patient resuscitated by the screams of a frantic relation; the Malays of the East Indies keep their relations alive by constantly druming at these doors. 9th. Affusion. of this remedy I can say nothing from my own experience, but only upon the authority of Dr Currie and Dr Jackson:  (159) it insures reaction if it fall from any night, but ablution as being a sedative, would rather destroy life; it is therefore only useful in Typhoid. In favour of Affusion Dr Jackson says that Soldiers march with less fatigue when stimulated by rain than when marching in dry weather; he also recommends, preparing the body for the water; by rubbing it with Sp. of Turpentine or Brandy; tepid water is to be preferred for affusion in the low state of fever; but there is one objection to it, which is the difficulty of applying it, for how will we get our patient out of bed in that state; he must have a number of male attendants. When applied the skin should be wiped quite dry with great care, otherwise it would have a Sedative effect - Cautious to be observed in the Treatment of Fever 1. Beware of forming sweats; Sir John Pringle says very properly, a moist skin is favourable; sweats for the most part, usher in death; Morgani mentions a disease in Italy which killed all by propose sweats, while the Physicians were encouraging the Relations  (160) 2. Beware of purges - One stool a day and that affected by a Clyster is all that is necessary; but on the other hand where the weakness is extreme, it will be well to have a stool only every 2 or 3 days; in fact it would be desirable, since the stimulus of the fœces will help to surport life - 3. Attend to the urinary passages: the urine may be retained without the patient having notice of it from pain; therefore it should be drawn off by a Catheter - 4. Never allow your patients to sit up on either to change their sheets, to make water or emit their fœces; in every case the bed path and male pessary should be used, Mr Pack, a physician of Liverpool has invented one for females - fainting and even death has been produced by going to a close stool - 5. Beware of the warm bath to the whole body, as it cannot be done without removal from bed, which I have just forbidden. I have heard of a contrivance, consisting in envelloping the patient in an oil cloth bag and then filling it with water; this may do; our  (161) patients should be washed with soap and water every two days - 6. Beware of cold drinks; recollect the differences between the sensibility of the skin and Stomach; I know it has cured it but I hope Solitary facts are not to destroy general principles - Great thirst should be considered an alarming symtom; it arises from the last retreat of morbid excitement to the fauces and stomach 7. Beware of allowing your patient to sleep more than two or three hours; when it happens we must wake our patient to take aliment and medicines; this should not be done when the sleep was brought on by a large dose of Laudanum; for here, by the stimulus of the opium, the system is kept alive; our patients often sleep 8 hours from opium and awake refreshed - 8. You will be surprised at my P the caution; that you must beware of the remedies and cautions I have suggested to you, and this for the following [cross out] reasons - Because the Typhus Mitior takes on the appearance  (162) appearance of Typhoid, while the Typhus assumes the Synocha and Sychocala action so as to require bleeding at 17 or 18 days; at other times they are mixed from beginning to end. - To distinguish these mixed states of fever will be attended with a degree of Solicitude, which the mechanical nosologist knows not; our practice may be compared to that of a skilful mariner who reaps or spreads his sails as the force or direction of the wind indicates; remember the 3 imperative rules of Hippocrates, Abstine, Sustine, Siste; and I am sure, If the blood vessels could speak, they might say, in the evening stimulate me, in the morning deplete, and at noon Doctor do nothing. Fevers are the evident outlet to life, and consequently decrease particular attention to their phenomena - 9. My 9th caution is against the fatal effects of that debility succeeding fevers which terminate suddenly -  (163) Of the Treatment proper during the Convalescence from Fever - In the restoration of the ratio between the excitement and excitability, or in other words, in the recovering from the debility following fever, depends the chief skill of a Physician; a larger proportion of people die in this state of debility than in the fever itself; it is now cordial aliment should be given; in the intermissions which happen at night [cross out] hundreds have been lost, who might have been solved by a little wine whey, Laudanum or a pupil to watch all night; this state, of which nosology takes no notice, is called convalescence; it is a compound of debility excitability, and a certain small portion of disease; in this state, the system is subject to relapses or chronic diseases; we should prevent relapses by forbidding ardent spirits, wine or animal food; the caution applies to animal food,  (164) for our patients never have an inclination for ardent Spirits or wine - It will be necessary also to restrict our patients, in the gratification of their venereal appetite, in riding, walking, and in business, as also to enforce our restrictions by letting our patients, how much more dangerous relapses are; this was proved especially, [cross out] in our military hospitals. Beware also of exposing your patients to a current of air. I have said a small portion of disease accompanies convalescence; I now say it is sometimes attended with a chill, a fever, and sometimes night sweats; in this case always bleed whether the pulse be full or not; dropsy and Consumption may arise from want of attention to this rule, and I add with confidence that in giving it I do not anticipate your reproaches from its unsuccessfulness, so sure am I of the correctness of [cross out] a practice supported both by reason and experience; if congestion of the liver  (165) or spleen [cross out] be the consequence of the fever, then a few grains of Calomel, and frictions and blisters to the part are the proper remedies: in convalescence the pulse should not ever be naturally frequent at once; if our patient cannot sleep, give him Laudanum; madness has been the consequence of this distressing relief of a Typhus fever; if there be no appetite, give the elixir of vitriol; if swellings of the legs attend, remove them by rubbing upwards; the deafness of ten following fever is to be cure by the usual remedies; Costiveness should be removed by Rheubarb and other gentle purges; the falling off of the hair which sometimes takes place is cured by time; we must also leave to time the recovery of the memory, or a deranged moral faculty or understanding; the venereal appetite is often excited at the crisis of a fever; hence we have the reason why the great Howard married his maid in a convalescent state from fever; the same thing  (166) I know of two Clergymen, whose piety would not pursuit them to gratify their lusts in an unlawful way; 12 !!! men, who were recovered at Bush kill from fever married before they left the hospital - The stimulating quality of the food of our patients, should be gradually increased with their recovery, and in the following order, 1st Bread and milk, then the pulp of a roasted apple or peach, then tea Coffee and Chocolate, then oisters raw or half roasted, next scale fish, chicken water or a boiled Chicken, now wild fowl, and lastly beef stakes and ham; but in every case let the food be taken in small quantities but very often during the day - Wine, in convalescence is not so much liked as porter, but either may be taken in water; when the wine begins to afford a burning sensation to the mouth, it is a good sign, as it indicates a return of sensibility - 2. It will be well in convalescence to remove our patient to another room to prevent disagreeable associations -  (167) 3 Changing the clothes, shaving the beard, and even pamdering the hair may have a good effect; recollect the hypochondriac who cured him - self of low spirits by changing his clothes - 4 The 4th way of removing debility is by riding in a carriage; but beware of the night and morning air as well as fatigue - 5. To accellerate other methods of cure, give Huxorn's mixture, but not for any length of time for fear of be getting an attachment to ardent Spirits - Violent fevers often drive away chronic complaints - 1 As the Plague has been known to drive away gout. 2. Persons often come down from their rooms, after [cross out] fevers, both stronger and fatter, and often with more symmetry and comeliness - 3 The plague has removed barrenness; Dr. Hodges remarked this - 4. Fevers have elongated persons, especially those A That is the third the fifth or the seventh B of the 13 remaining cases, 11 terminated on non critical days and in death; nothing is said of the other two cases - C He says it arises from the morbific matter being assimilated to the fluids of the body; but this cannot be the case, since the discharges, when they do come on are not acrid or [cross out] morbid - (168) approaching to manhood - Of Critical Days. Fevers have critical days, especially in the mild and invariable climate of Greece, where Hippocrates took notice of them under the names of dies judicii - Every fever comes on as a tertine, but from stimulation, it does not always appear as such; hence they generally terminate on the third, 5th, 7th, 9th, or 11th day; at other times they are quartan, terminating on the 14th. 17th or 20th day - The yellow fever almost invariably terminates on a tertian day, A though it rarely terminates [cross out] on an even day; out of 60 patients, 47 ended upon critical days and favourably; B Hippocrates says, two-thirds of all fevers terminate or critical days - Sometimes decreases terminate without any discharge; Dr Sydenham explains this by the humour of pathology; C this is called tapering off, but when they terminate suddenly diseases are said to snap off A By a knowledge of the critical days you have the following indications - (169) 1 A On critical days, the system will require more bloodletting - 2. You may give purges with more safety, by an attention to the critical days - 3. If the paroxysm has a tendency to return on an odd day, it requires to be attended more particularly, than if you are threatened with one on an even day - 4. When you are in doubt about the use of bark, give it on a so non-critical day, for if it does no good, it will do less harm, than if given on a critical day - 5. By attending to the days which are critical, we often tell when our patient will get well, if the fever takes place in August, it will probably terminate in 3 days, if in Sepr. [cross out] in from 3 to 5 days, if in Oct. in from 5 to 7 days. Of the Influence of the Moon upon Fevers Dr Balfour contends that fevers are affected by the Moon; Dr Moseley says any difference in fevers then, must be ascribed to the increased A Dr Balfour remarked that the fever was worse on the full and change of the Moon - 1- It lessens the effects of pain, by being able to tell our patient, that he will get well - 5. and lastly, a Physician often gets more credit for making a correct prognosis than for curing the most difficult diseases - (170) moisture of the air at that time; but the same influence is observed at a distance from the sea; Dr. Maurbrook remarked it in the plague an hundred years ago, Dr Peirtard remarked the same at Surinam, Dr Moseley said sores were worse at the lunar period in [cross out] the West Indies - These things teach us to give stimulants on the lunar days, A and after recovery to give preventives on the non-lunar days, as Tonics will act better here, as they meet the system in debility. Of the Prognosis of Fever - To make these anticipations is useful - 2. Because it prevents the wasting of property - 3. By preventing sharks to relatives, should the death not be expected - 4. By giving opportunities to the patient to settle his affairs, and prepare for a future state - To make these anticipations is very difficult, since the same disease varies in different seasons and countries ; the signs vary in the difficult A Thus a hoarseness was a favourable system one year, and a bad one the next in yellow fever. 2. There is a differences in the issue of the same signs in diseases of the same class but not of the same grade; thus deafness &c B The appearance of black vomit has sent many to the grave from the fear which it instill in the patient. (171) difficult grades of the same disease; A thus deafness is favourable in such bili. fever but unfavourable in yellow fever; in Typhus fever sensibility to a blister is good, in yellow fever, bad 3 The diseases of Children are different; [cross out] thus they recover from the black vomit; but this is owing 1st to their greater tenacity for lifes and 2nd for the absence of fear for futurity, or for the tendency of symtoms - B 4 further, symtoms, not mortal to middle life, would be certainly so to old age, lastly many things vary the mortality of symtoms, such as being either robust or weak, the sexes, whether of long or short livid ancestors or whether drunken or sober - or whether a freeman or a slave - Symtoms favourable or unfavourable 1. The violence and danger of a disease maybe in part predicated on the violence or danger of the exciting cause - 2 Diseases, which come on without premonitory symtoms are dangerous - as for instance an apoplexy - 7- The fever suddenly to subside is a bad sign, unless it be produced by suddenly affections - (172) 3. If the accession of the disease be very gradual will render it more protracted and dangerous - 4. If the disease comes on without a chilly fit, it proves the disease to be confined to the blood vessels; if after bleeding, a chill should come on, it is favourable, since it proves the disease to be let loose among the other systems - 5. The danger of fever is greater, in proportion as the connection with other systems is destroyed; hence it is that Hectic fever, in which all the systems except the sanguiferous, are either passive or healthy, is so fatal - 6 Paroxysm which come on [cross out] on an even day are [cross out] more dangerous than if thus come on, on an odd day. 8. To hear a person say, he feels too well is a bad sign !!! - 9. Chills at the close of a chronic fever are always favourable - 10. Procrastinating [cross out] fits are favourable, anticipating infavourable. Lastly Violent fevers are dangerous in Pregnancy, A Thus also a bilious Pleurisy is more dangerous [cross out] than a simple Pleurisy - (173) as the system has to contend against two diseases A Signs taken from the Body I of those divided from the Blood vessels - 1. If the pulse be preternaturally slow, it is alarming in children - 2. The intermitting pulse is alarming; it is worse when it takes place every two strokes; if the intervals be still shorter, it is less alarming; Dr Heberden mentions a man whose pulse was always intermittent in health, but natural in disease - 3. A pulse in fever above 120 strokes, is called a rapid pulse; I always fear, with this pulse, but yet I have had a recovery after a pulse beating 180 - 4. Fevers with a natural pulse must be respected - 5. You should respect a pulse which is frequent in convalescence; Dr Stohl says, the pulse does not indicate disease in the lungs - 6. Hæmorrhagy in the beginning of fever is good, at the end bad- If from the stomach liver eyes skin or old sores it is bad; but from the B Long protracted chilliness, and universal coldness unfavourable - A upon the mouth and tip of the tongue C For it indicates a common synocha D It may to arise from a deficiency of oxygen (174) [cross out] Uterus, hæmorrhoidal vessels or nose it is good - II Signs taken from visible parts 1 Partial heat or cold is always a bad sign; as the feet being cold and the breast warm; to have the hands warm and wrists cold is always fatal B 2. Both the Color Mordeus and a natural heat are unfavourable 3. It is unfavourable, should no heat attend Convalescence - 4. Sores A are favourable, if they take place after the 3rd 5th or 7th day; but sores in the pharinix larinx, œsophagus or [cross out] root of tongue are always unfavourable - an old sore to dry up is unfavourable. III Signs taken from the Tongue If the tongue be white, it is not unfavourable, because we expect it, C if yellow, it indicates bile in the stomach, and is not unfavourable; when it is red and smooth, it is very unfavourable, as well as when black; but distinguish it, from the black produced by liquorice, tobacco, claret, or black jellies D when the tongue is green it is bad. I have seen but one instance, which was fatal - A dry tongue is unfavourable, A I knew a lady in a bilious fever whose tongue was only dry when she [cross out] laid on her right side - B a livid colour of the nails or fingers is unfavorable C also a placid countenance, is unfavourable, but a red countenance becoming pulse is favourable - (175) unfavourable, but you must not be deceived by the dryness, produced by breathing with the mouth open; Dr Bordul says a matter like the white of an egg upon the tongue is favourable; A if the tongue appear natural it [cross out] is very unfavourable, since it proves the disease to be concentrated in more vital parts; Moisture, when it takes place suddenly after dryness is unfavourable, if slowly favourable; when preternaturally hot, unfavourable, unusually cold, mostly fatal B IV. Signs taken from the Countenance - 1 Frowning or a likeness to ancestors is unfavourable; as [cross out] it proves great emanation, causing the projection of the bones, which parts are mostly like ancestors C 2. The Hippocratic countenance is bad; it is as follows - V Signs taken from the Muscles The fallen jaw on inability to protrude the tongue, a slipping down in bed, and an inability to raise the arm are all unfavourable indications - Convulsions in the beginning of fever, are unfavourable; should A A Priapism is sometimes a sign of returning health, and sometimes of death - hickup is always unfavourable B decending pains are favourable, ascending unfavourable; moving pains more than fixed - (176) you find your patient on his side after having laid several days upon his back, it is favourable - A VI Signs taken from the nerves and Senses - When they are incurable to heat or cold, it is bad, return of sensibility to a blister is favourable, except in yellow fever; pains in the back are favourable, since it proves the disease to have a centrifugal tendency; B pain after bleeding is always favourable, a burning sensation in the stomach or bowels is bad, an itching on the head or tongue is favourable; the return of old habits or chronic diseases is favourable, as when a chronic costiveness or headach comes on; great acuteness of smell is unfavourable. A contracted or enlarged pupil, an intolerance of light, perpetual motion, and winking are unfavourable, the half closed eye (except in Dysentery), one eye larger than the other, a glassy appearance, a defect of tears, pulse and double vision, involuntary tears, blindness, squinting, a sudden appearance of animation in the eyes, matter lodged in the inner ear this a film A The pupil of the eye becoming of a lighter colour are all unfavourable - (177) on the Cornea, A and according to Dir Mourbrick, seeing a rainbow, are all unfavourable - Acute hearing is unfavourable; some of the patients in the yellow fever, could hear across the Street; turning when the door opens, is favourable. VII Signs taken from Respiration &c - 1 An alternately frequent and slow breathing with an expansion of the alæ nasi is unfavourable - 2. A Cold breath or the rattles, is unfavourable - 3. A quick, stuttering or drawling voice, if not natural is unfavourable - 4. A wispering or loss of voice is unfavourable; lymphatic swellings are favourable in mild, but dangerous in violent fevers; great spitting is favourable; great or little stench, unfavourable; an appetite for particular fluids, or aliments is bad - an appetite for particular aliments is bad, but Dr Sydenham had one exception in a chronic fever. VIII Signs taken from [cross out] Secretions & Excretions 1- Sweats are unfavourable, but a Mador good - A Coffee coloured or bloody urine, as well as high coloured urine are unfavourable A continual nausea [cross out] well as vomiting at the close of a fever is unfavourable (178) 2. Partial or cold sweats are bad - 3. Saline or acid sweats are good, according to Dr Huxon; but when they have a putrid [cross out] taste or smell, it is bad - hence Dogs, from perceiving the smell, often howl about a hour, in which there is a person about to expire - Suppression of urine, its excess or defect in quantity, its paleness, and its being discharged involuntarily are all unfavourable indications; the last sign is less alarming in women than in men, as the same effect is produced in them by coughing and laughing; a sediment in the urine is favourable; it is distinguished from gravel affections by swiming; gulping [cross out] in discharging great quantities of air from the stomach is bad; the [cross out] contents of the stomach to stream out of the mouth; [cross out] also to vomit up fluids as cold as when taken is unfavourable; obstinate costiveness is bad; involuntary stool, and evacuating air without noise is bad; natural stools and crepitus, after the contrary, is favourable; an habitual hour for going to stools is favourable - Discharging worms with fœces A Slowness of answering questions is always unfavourable, as also the patient having a presentiment that his disease will prove fatal; it is a good sign when the patient inquires concerning the health of this physician's family - (179) and slime, in the beginning is favourable, but in the last stage of a fever without feces or slime, unfavourable - Signs taken from the Mind - Indifference to life is a bad sign; great laughter or great crossness at a crisis is favourable, asking the hour of the night is favourable - a desire to be removed is unfavourable; desire of life is favourable; it acts as a stimulus and [cross out] cooperates with you - a want of affection for relations is bad; the return of mental habits, as of wit, of crossness, or an apology for want of order in the sick room, are favourable - Thus I have mentioned all the Prognosis of fever; I have divided them into grades by the epithets of unfavourable, bad, dangerous, fatal - but yet persons die with every favourable, and live with [cross out] every unfavourable symtoms, except indeed, [cross out] the cold wrists, with warm hands, and the half closed eyes in adult (except in Dysentery), from which symtoms I have never seen a recovery - We must beware or giving direct answers to the friends of patients [cross out] about the termination of their diseases since all the signs deceive use sometimes, hence you may say that you have seen persons recover who appeared much worse and others dies who appeared much better - (180) Before I enter upon the 6 forms of bilious fever, I shall deliver some new views upon the Hectic fever - Hectic fever This fever arises - 1- From Consumption, but oftener from sores in the joints - 2. From scirrhi and scrofula without sores, as in the breast, stomach, and Uterus - 3. It arises from obstructions in the viscera - particularly the liver - 4. From Gall-stones and stones in the Kidnies - 5. From Pins or sharp substances - 6. From Leucorrhœa and Menorrhagia - 7. From Slow passions - 8. From high excitability of previous disease, acted upon by great stimuli - 9. Exhalations from Metals - 10- Dr Hamilton mentions an instance from home Sickness -  (181) 11- From Pregnancy; I have known two instances, which terminated fatally in Abortion of dead children - To understand this fever, it must be recollected that local inflammation is produced by local injury naturally; but should a part not inflame which is injured, then the whole system which is injured wishes to produce the cure - thus it is when inflammation does not follow the wound of a tendon, the whole of that system is sure to take up the dispute!!! and produce Tetanus- now in the same manner I believe [cross out] when local injury takes place in other parts more intimately connected with the blood vessels, and is not attended with local inflammation, that then that [cross out] system takes upon the quarrel!!! and produces Hectic fever - Hectic fever may be distinguished [cross out] in the following ways from Intermittent fever 8. In Hectic fever, the urine is turbid A when it arises from a mineral atmosphere or any other irritant, the patient must be removed out of their reach - B I have generally found the [cross out] blood 1787 - (182) in the fit and clear in the interval, in intermittent it is vice versa - 9. The hectic is attended with swelling - 10. The hectic fever comes on gradually - 11. In hectic, there is a deep colour in one or both cheeks, which is distinguished from health by being without intermediate shades at its edge - 12. There is [cross out] less headach in Hectic - Lastly in Hectic, the appetite and bowels are in good order; it generally occurs about the age of 45; the pulse is sometimes synocha and synochus mostly Typhoid, but rarely Typhus - Method of Cure - All things which are in the reach of Surgery should be removed as ulcers, pins, stones in the bladder - A It is difficult to cure, since it is insulated, like Tetanus, Cancer, Tic douleureux It is the same with solitary vices - 1- The first remedy is bloodletting, if the pulse be [cross out] synocha or synochoid B A Perhaps it has been given with too little attention to the pulse; I am sure it would do good in the typhus state - B But there are persons who cannot purchase this remedy, and the season [cross out] may not be favourable; what are we to do here? I say substitute labour or a Salivation - (183) 2. nitre to take down the pulse when the pulse will not bear bleeding - 3. A Milk diet; would it not be better to give rice or whey, and weigh the patient's food? 4. Hops are good, or the powder of Malt - 5. Arsenic promises most, when it arises from the obstruction without inflammation; Bark has often done harm, as well as bitters; A Digitalis has been tried; this disease, like the shirt of Hercules, cannot be cut or turn off, but it has shaken off by riding on horse back; B a Salivation and labour are revolutionary and cheap remedies - Some Questions - I have supposed Hectic fever to be owing to the Blood vessels taking on a vicarious office, if this theory be well founded, I would ask what would be the effect of irritants to the injured part, to bring back the action there; and should you not be able to reach the injured  (184) part, why not translate the disease; a phlegmon has cured a hectic fever - and cold has suspended an asthma - 2nd Question - I have said the disease is insulated in the blood vessels, and have also taught that it is for this reason more dangerous; now what would be the effect of tearing the disease from the blood vessels by large purges or vomits, or by irritating the skin by cayenne pepper or Cantharides; the sweats in Hectic suggest this best remedy - Six forms of Autumnal Bilious Fever these are 1 The yellow fever 4 The intermitting fever 2 The inflammatory bilious fever 5 The Ch. Bilious fever 3 The mild remitting fever 6 The Febricula. Before I treat of them individually I shall make a few General Remarks 1- You must not expect one form of the same fever, you will do harm if you do - Dr - A This is a treacherous remission as Dr Moseley justly calls it; for the patient is in great danger - B 2. It appears with a depressed pulse, and prostration - 3. It appears in great depression - 4. It appears as a synocha - 5. It occurs in colics - 6. It occurs in the form of dysentery Diarrhœa - (185) did great harm by describing but one yellow fever, and by saying it only termitated on the 5th or 7th day. A Physician lost a patient in the yellow fever on the 14 day, but contended, it was not yellow fever, because it did not terminate on the 5th; believe me gentlemen Diseases are not to be modelled by nosological chisels - 1 Yellow Fever - In this fever about the 4th day, the patient sometimes appears better, his skin is cool, his appetite returns A but Dr Leinin has done great harm by saying, that now the fever was going off; but the mild symtoms arose from the system being depressed below the point of reaction; now this is proved by Stimulants killing - This fever appears 7- With Blotches buboes carbuncles - 8. In the form of a tertian intermittent, and A Milk of the Coconut - X Made into a tea - (186) that of the most obstinate kind - 10. It appears as Febricula - 12- [cross out] In the form of universal yellowness - 14- Burning of the skin - 15- Disposition to faint - 16- Coldness on the skin - 17- In petechial spots Means of preventing vomiting in Yellow Fever It may be removed - 1- By bloodletting - 2. By washing the stomach by frequent draughs of hot water - 3. By weak Chamomile or mint tea - virginia make root; milk, A lime-water and milk sweet oil, sweet oil [cross out] molasses and milk, opium when the pulse is reduced; a clyster of warm or cold water, Oats roasted X 10 drops every two hours of the Sp. of Turpurtine, not given too early; this has been used by Dr Physick as an injection; abstinence [cross out] from drinks and meats; blisters to the stomach, cold water A Putting the hands in cold water - For Diarrhœa - A Plentiful purges afterwards by bark and blisters; and if these fail you must resort to it a salivation - But the state of the pulse must regulate this remedy; in some cases it is unnecessary (187) to the belly or hands; A yeast carbonic acid; For the bl. vomiting opium; Cayenne pepper, acting by paralyzing the stomach; cretaceous jalaps; cold water to the head, or alternate heat and cold to that part - this is recommended by Dr. Peritard; hot or cold water to relieve the bowels by injections - Suppression of urine is relieved by the Catheter, Coma by Cups and blisters to the neck - II Inflammatory bilious Fever This grade of fever is between the yellow fever and the mild bilious; it is cured by bloodletting. A purges. bark, and a Salivation - III Mild bilious Fever - The best authors on this subject are Cleghorne Hilary, Clarke, Moseley &c Jackson and Dr John Hunter The remedies are 1- Bloodletting - This evacuation mitigates the violence of the fever, and prevents the bad consequences which [cross out] would otherwise follow -  (188) 2- Purges - I formerly tried to cure this fever through the pores by the use of antimonials- purges Salts, cream of Tartar, senna, Calomel, may be used; I relieved by purges in the break bone fever; its name imports the viscera to have been safe. 3. Vomits are proper in the presence of nausea, or when there is great inclination to discharge bile; cold water is more proper here, than in yellow fever - 4. Blisters often act like a charm, about the 4th day, when bark will not stay on the stomach, take bitters - a Salivation is seldom necessary - IV Intermittent fever - This is a very common fever in our climate; it is called the dumb ague, when without a fit, They are quotidian, tertian, or quartan; it often continues a long time, Bruce the celebrated african Traveller had it 13 years; but it is never incurable  (189) when taken in time; it rises and falls with the action of miasmata; it has been induced by a Salivation, and gout sometimes puts on this form - The state of autumnal fever has different forms as - 1 The malignant form, 2- The highly inflammatory, and 3- mild form; all of which requires different remedies, even the mild form requires different remedies, as its beginning and end, or when it occurs at the beginning or the end of the Season - The remedies divide themselves into such as prevent it, such as are necessary in the interval, 3rd Such as are necessary in the fit Intermittents are known - 1- By intermittents being epidemic at the time - 2. By the length of the fits - 3. From the presence of bile in the stomach - 4. From the time at which the fits occur, as quotidian in the morning, tertian at noon, and quartan in the evening - 5. From their generally prevailing in climates  (190) not very hot nor very cold - 6- From the urine being clear in the fit, but full of sediment in the intermission The Method of Cure The remedies just before and during the paroxysm of the inflammatory intermittent are bloodletting and after 3 or 4 fits the use of the bark; just before the fit, to give 30 or 40 drops of Laudanum often prevents it - Many other remedies have been made use of, such as wine and ardent Spirits, pepper, a teaspoonful of Sulphur and ardent Spirits; Stramonium, and Tobacco applied to the wrists, terror, a copious sweat before a fire; riding and dancing has been supposed to cure the bite of the Tarantula, where - as it cures intermittents - Cayenne pepper pills; but most of these remedies prevent the recurrence of the fit, but do not cure; it is bark, which is to remove the predisposing debility - It may be asked why Dr Horne recommends  (191) [cross out] in the Intermittents of the west Indies, bloodletting, and in the yellow fever of the same country, a contrary practice? the answer is that in the one case there is inflammation, in the other, exhaustion. - It has been the practice in intermittents, to wait two or three fits for the system to wear itself out; but it is much better to take down the system by bloodletting, for thus we often convert an intermittent [cross out] into a continued fever, which is changing a sturborn [cross out] for a tractable disease; Bark should never be given, unless the pulse be in a Typhus state; if excitement be above fear dropsical the consequence of giving bark; here effusion is often, [cross out] bleeding and blistering - must be used In the intermissions bitters are good, such as Calomel, Gentian, Bitters, Wormwood, centaury, Chamomile, Tansy. 2 astringents, as Galls, black oak bark - 3 a mixture of the tonic and astringent quality, as willow bark, logwood, poplar bark  (192) 4. Minerals - such as white vitriol and Sugar of lead - 5- Spicy substances; cloves nutmegs, black and red pepper - also glue, turnips, to the thighs, a spider's well marked in bread, intoxication, salt and the white of an egg, stramonium or Tobacco to the wrists and arsenic - 6- Tourniquet upon the thigh renders the pulse softer and fuller, laying in bed and fasting has a good effect - But these remedies are generally superceded by the Peruvian bark; vomits have been given to prepare the system - The best time to give bark is just before the fit; it may be given in powder, or infusion, either cold or hot, extract or tincture; but this last preparation should not be used, for fear of begetting a relish for spiritual liquors - Bark is prevented from acting by the following  (193) following circumstances 1 From the existence of the inflammatory diathesis, - this must be removed by bleeding - 2. From visceral obstruction, here also you must bleed - 3. It may be [cross out] from giving too small doses, here then increase them - 4 Or from too large ones, here diminish them - 5- From [cross out] long use; here then it must be laid aside, or mixed with make root or Iron - 6. From its either producing costiveness or looseness, both of which must be obviated - 7- Or lastly, From the bark not being good; here get better - But for the removal of almost all the causes of the want of effect of bark, the Lancet should be resorted to, and in every case you will have sizy blood- I cannot leave the subject of bark without remarking the exalted station it has held in the Materia Medica, for so long a time; to its use millions  (194) owe their lives; it was discovered by an Indian introduced by a Priest, [cross out] vyed down by the regular Physicians, and revived by a quack - This fever has disguised forms - It appears in Sciatica; when natural!!! headach!!! arises from decayed teeth - as also in the form of Puerparal fever; and sometimes in Madness - It also appears in the form of tenesmus and vomiting; as also in a periodical fever in a part of the body only, as in the right arm; Dr Moseley mentions this - This fever terminates - 1. In Pulmonary Consumption, cough, or fever - 2. In Obstructions of the Omentum liver and spleen 3. In swelled legs and Jaundice - 6. In Hectic fever; a Salivation promises much here - Dr Clarke mentions some circumstances, which would make it likely its ware contagious - Probably those obstinate intermittents which Dr Bond cured by Salivation were of the hectic kind -  (195) V The Chronic Bilious Fever It appears on Synocha, synocula, typhoid and Typhus - 1 In this fever it is necessary to open the bowels more by purges than in other chronic fever, because it is necessary to remove the bile - 2. you must use the lancet even to the close of this fever, should the pulse be full, or the patient in pain; in some instances even [cross out] the 30th day - VI Febricula - This is the last state of autumnal bilious fever; it occurs in intermittent!!! countries, its symptoms, a frequent pulse, little headach, slight heat, high-coloured urine - The Remedies are vomits, gentle purges, Blisters Bark, and lastly bloodletting if the pulse be corded - Remarks on the Plague - 2. This fever, like the autumnal bilious fever can nix forms 3. It can be taken any number of times - 4. It attacks strangers more than natives -  (195) 5- The young and Robust are more subject to it, than the old and feeble - 6. It is worn during moisture - 8. It is not contagious; this is proved by Sir Welham Wilson and Assalini; the supposition of its non - contagiousness is an old opinion; to prove it, two dissertations were printed in 1721 and 1722 - 9. Cold and wet weather remove it - 1. It is hot climates attended by less reaction - 2. It affects the lymphatic glands more than the yellow fever; buboes and carbuncles are less common in yellow fever - 3. In the plague of a cold climate, is, in yellow fever there is a centre!!! petal tendency; hence a bubo with us indicates the disorganization of the bowels- It is singular that a bubo in the right grain indicates the disease to be at; its hight, whereas [cross out] its decline is shewn by its being in both!!! -  (196) 4. It has appeared in a sweating form, called the sweating sickness - In Hartford, Con. the Dysentery was more [cross out] fatal than even the yellow fever was, the year before; and yet [cross out] the inhabitants contend for the domestic origin of the former and not of the latter!! Nosology like a Polypus, meets me in every part of my course - believe me, it is as absurd to suppose that morbid excitement can be cut up according to the part affected, [cross out] just as the belief of the suitor that old!!! Moon!!! are cut up into Stars!!! - Hence I believe that the Asiatic and African plague are the same disease as our yellow fever, differently modified by climate - Of the Remedies - 1. Sweats have been used with advantage by Dr. Sydenham in curing the London plague - 2. Vomits and Purges - 3. A Salivation, if it could be induced in 24 hours would be good in chronic yellow fever; Sir Robert  (197) Wilson says that opium and Mercury wine the most successful medicines in curing the Egyptian plague during the stay of the British army there - 4. A new method was used in curing this fever, that of wrapping the body in numberless folds of linen, for the purpose of producing profuse sweats; we know that Swiming over the Thames cured the Plague in London, and a shower of rain has had the same effect, they both act probably by reducing morbid excitement - Typhus fever The Opium Fever This fever takes place when this substance is taken in a large quantity either by mistake or to destroy life - It is attended with inflammation, depression [cross out] or prostration - It is cured 1 By rejecting the Laudanum by Emetics; a feather may be useful thrust down the throat; an half gallon of water may be given; it acts by distending the stomach,  (198) and diluting the Laudanum; but if vomiting be excited without relief - 2. Then bloodletting may be used if the pulse be active - 3. Affusion of Cold water to the head, Dr Griffits cured this fever by cups to the temples, also flagelation; remember the dog and the nux vomica, formerly acids and sweet oil were used to blunt the opium; and other remedies to defend the system; after the depleting, [cross out] the stimulating plan must be resorted to, such as clysters, Cataplasms, sinapisms - The Mercury Fever. This noble medicine, although so valuable in many, is yet the cause of some, diseases - It has induced a Tertian and Quartan fever, the Synocha and Malignant fever, Hemorrhagies, Diarrhœa, Dysentery, Angina Pectoris and Rheumatism - But it is said that the hydrophobia affects the nerves more than the blood vessels, therefore it is not a fever, but some malignant fevers affects the nerves more than the blood vessels - It cannot be communicated by biting in the human species!!! or in horse cattle!!!; it cannot be communicated by kissing or coition- (199) The Hydrophobic State of Fever For a minute detail of this fever I refer you to my Inquiries - I believe it to be a fever of a highly malignant kind; but Dr Currie says it is not inflammatory because their exists no febrile heat - but this is no reason, because the fever may be so violent as to transcend the inflammatory type; it is known as well by the dread of air as of water; but neither of these syntoms is invariable It arises spontaneously in Dogs Cats Foxes and Wolves only; it cannot be communicated by eating the flesh of sheep or hogs dying of hydrophobia; nor by the milk of Cows similarly affected; The cause in Dogs is heat or want of water and aliment - The disease affects the blood vessels and nerves generally, but especially the larinx and glottis; hence from the constriction of those parts the mad Dog is [cross out] unable to bark; hence we need not fear a dog that barks - It has been communicated by rabid lap [cross out] dogs in 6 instances!!! through the medium of the lips - 1- The first preventive is excision - there is one instance in which it is said to have failed; it will succeed at any time after the accident if the symtoms!!! of the disease have not taken place!!! - often the excision, the part should be kept open for several weeks - (200) The subject divides itself into 1- Those remedies which are proper as preventives and 2nd check as are necessary when the disease is formed - 1. The 1st preventive is the excision of the part - Dr Physick has thus prevented the disease 15 days after the bite was received; there is no danger if no blood be drawn - but yet it does not always produce the disease when it is drawn; it is same with the variolous matter; either from idiosyncrasy or being washed out by the blood drawn - Dr Hunter proved that the variolous disease could not be taken, if the wounded part was excised on or before the 6th day - 2. The 2nd preventive is Caustics; there are the nitrate of Silver, the Caustic alkali, Lime, hot vinegar, and Sulphuric acid - 3. Affusion from a tea pot on the part, to wash out the poison; but I don't recommend this - 4. Suction; This was practised successfully by Lenora, upon, her Husband Edward of England; [cross out] Even at this time the wound should be opened afresh - it has different grades; synochus fortis, synocha, and typhus gravior; there is a constriction of the glottis and the patient has at first a hoarse cough; a salivation may be used; after the patient gets below far then Stimulants - (201) and we have an instance of it which took place in Ireland; Recollect the impressive case recorded by Dr. Forthergill, in which two persons were bitten at [cross out] the same time, one of whose died, but [cross out] the other being a washer woman, and having the bitten part (her hand) constantly in the wash tub escaped the disease - Some have tried to discover something, to throw the [cross out] poison out of the system; but this attempt is fertile, and attended with the loss of your patient, the disease generally takes place in a month or six weeks, but in an instance in Dover (Del) it did not appear untill 10!!! years- I refer you to Dr Hillary - Remedies proper after the Fever is formed. It has been said to have been cured by sweats, purges and a Salivation, also bloodletting as well as other remedies such as plunging the patient repeatedly in water, it acts by creating a fear of drowning - What would be the effect of pouring water on the A and as the nerves are very much affected we might use Castor and Musk - I mention Mercury as in stimulant because it is essentially so when it does not affect the salivary glands - (202) patient from a great night? what would be the effect of excititing a great action on the skin by the Sp. of Turpentine or Cartharides? Spallanzani is said to have cured a Dog of Hydrophobia, by letting him be but by a rattle make; what would be the effect of this counteracting stimulus upon the human subject? What would be the effect of Ether Laudanum &c, but in 4 times greater than common doses? what would be the effect of translating the action from the larinx to the throat by external application? and lastly what would be the effect of violent and repeated emetics to weaken the larinx which is the head quarters of the disease; for Dr Physick affirms, that death is generally produced, if not always, by strangulation; nor is this disease alone in this respect; since Cantharides acts on the neck of the bladder, Mercury on the Salivary glands, and the Eupas on the lower jaw producing lock-jaw - thus Dr. Physick A But when we perform this operation we only [cross out] obviate the effects of a symptom; we have to contend still with the disease - Sulphur [cross out] has been recommended to to prevent the effect of arsenic, but I doubt whether an orpiment can be formed in the stomach when the poisons gets into the blood Fever is the consequence, and here use remedies, such as are necessary for other fevers; we need not seek & any thing to discharge the poison from the blood - I have heard that the natives of S. America cure the bite of a Snake by exciting counteraction in the stomach by cayenne pepper - (203) has with great boldness and ingenuity suggested the propriety of making an artificial opening into the larinx, communicating externally, which would effectually obviate the production of Strangulation, so far as it would depend upon constriction of the Glottis - A The Fever produced by Poisons - When taken into the stomach their effects are obviated in 3 ways - 1 By removing the substance from the stomach, 2. By neutralizing it by some other substance and 3. By producing a new and greater action in some other parts; thus, to destroy the Muriate of Mercury make in of the alkaline salts; it may be necessary to blunt the effect of the extraneous body by Diluents such as milk or oil. [cross out] Diluents act by diffusing the poison. If the patient cannot swallow, then produce a tendency to the skin by counter-excitants. For make bites, use excision, inflaming applications, Of those states of fever which affect the whole arterial system, but appear with greater morbid excitement in some parts than other These are * I The sweating State of Fever - A when poisons produces the maniacal hysterical dysenteric or eruptive state of fever, in the remedies necessary these states; Some poisons affect the skin only, and the blood vessels only by sympathy, or the bite of the mosquito the effluvia from the Rhus Radicans - (304) A applications, suction and ablution - burying the part in the ground - I The Sweating State of Fever - It arises from too great or too little morbid excitement in the blood vessels - when from too great excitement the sweating is generally in the day when from too little, at night; they might be called Tonic and Atonic sweats - It appears in the Plague Pleurisy Intermittent fever, Pneumony and Hectic fever; when caused by great morbid action bloodletting according to Dr Sydenham, and sitting up in bed. have been used with advantage. In cases of weak action, Sulphuric and and other Tonics should be employed; but yet even in the typhoid state of the system, a small bleeding may be sometimes necessary; it is depleting by a smaller and safer outlet - II The Fainting State of Fever - This appears in all malignant fevers, arises from Prostration, and is removed by small bleedings, in A To prove that animal heat was not altogether connected with the form of the insulation - B afterwards frictions, and warm fomentations to the legs. (205) the Rheiverian manner - I have known fainting to attend a first and 2nd bleeding, [cross out] and yet not the third - III The Burning State of Fever - This is symtom of malignant fever and is either general or partial; it gives a person touching the skin, a slight pain, and is hence called Color Mordeus; I have heard a patient cry out with the heat!!! of the blood trickling down his arm when bleeding him; I once saw this Color in great excess, when the pulse was absent, this I mentioned in my theory of animal heat - A The remedies are two or three bleeding and cold water - IV The Chilly State of Fever This is distinguished from intermittent fever by the long continuance of the fit; it is cured by bloodletting!!!; I remember to have bled a Lady untill I warmed her feet B But let me conjure you not to view these forms of fevers A It has lately attracted the attention of Physicians of Europe; Dr Duncan has described it; it is attended with no [cross out] febrile heat or frequency of pulse - In the acute form there is only an increased peristaltic motion of the bowels, but no stricture - (206) under nosological Spectacles, for they are so mixed as to put on the fainty hot and cold stages in succession; But they almost all yield to bl. letting!!! - V The Petechial State of Fever - A This is a malignant fever concentrated on the skin; its remedies are bark, wine &c. it is the same to a malignant fever, as the _ is to the mild bilious - VI The Intestinal States of Fever These are Diarrhœa, Dysentery, Colera Morbus and Bilious Cholic - and first of Diarrhœa - 1 Diarrhœa - acute form This is excited - 1- By a cold evening following a warm day - 2. By exposure to night air - 3. By the suppression of a profuse sweat - 4. By the sudden evaporation of a sweat - A Thick as oranges Lemons [cross out] or pomegranate A Also diluting drinks as chamomile tea; if this fails, then inject Laudanum in the bowels - It has been produced by drastic purges. (207) 5. By a current of air, acting upon the whole or a part of the body - Of those causes which produce Diarrhœa, by acting directly upon the bowels, we have - 1- Fresh meat after long abstinence, also tainted Meat - 2. Bad fruit or too much good fruit; skin-fruits A are not so likely to produce it; these are oranges pomegranates &c 3. Too much cold water - Dr Duir mentions this - 4- By taking too much bitters to prevent it; Dr Duir notices this also It may be cured by purges, or an emetic and Laudanum at night; A I shall hereafter treat of the chronic form of this disease - 2. Dysentery - This is a higher grade of the last disease, and is produced by the same causes, together with human and marsh miasmata; bad wheat produced it in Minorca according to Dr Cleghorne, when seated in the lower bowels, it is attended with I have said that Diarrhœa was only an increased peristaltic motion, now Dysentery, added to this is attended [cross out] [cross out] with Stricture, convulsions and sometimes spasm - (208) great pain, which sometimes kills; but when seated in the upper bowels, it is not so painful, and is attended by anxiety about the precordia: sometimes, both upper and lower bowels are affected - We have a hospital camp and jail Dysentery as certainly, as a hospital camp and jail fever; that Dysentery is an introverted yellow fever!!!, I infer from the liver being in both diseases paralysed; sometimes there is no pain at all; thus patients will walk about the room with it, till a short time before their death; this is called a walking Dysentery; when the disease affects the rectum it is called Tenesmus - This is produced by 1- acrid matter in the rectum 2. From the diseases state of the contiguous bladder or Uterus - 3. From the presence of hardened fœces - 4. From the existence of an ulcer in the rectum - a tenemus from an ulcer is mentioned by Morgagni The pulse is seldom excited in dysentery, neither does pain [cross out] of the [cross out] head or delirium attend; I shall apply this hereafter; [cross out] it sometimes terminates in a few days - A That is, a disease with dysentenic pains without any discharge from the bowels - (209) The stools in this disease put on the following appearances, and in the following order - 1st Blood and Mucus - 2- Blood and a quantity of fœces; blood from dilated, but not ruptured vessels - 3. Mucus alone; coming from the great intestine 4. Fœces with mucus, but without blood - 5. Little balls - 6. Fatty balls; they may be coagulated chyle - 7. Serum or a matter as limpid as water this comes from the liver - 8. A Membrane, supposed to be the inner Membrane of the bowels - but this is an error - 9. Blood alone; such dysenteries are generally fatal 10. and lastly worms, especially the round worm - Dr Sydenham has a suffocated or dry Dysentery; A thus also we have a dry Opthalmia, a dry asthma a dry Gonnorrhœa - The patient sometimes feels as if he had no bowels, but more frequently suffers acute pain, generally seated in the Colon and rectum; sometimes the  (210) pains are in the mesentery; oppression shews the disease to be in the upper bowels, pain, the lower; recollect some purges are fitted for the upper and some for the lower bowels - In this form of intestinal fever the pulse is very various. - When acute, it destroys in in 3 or 4 days; when it last, two or three weeks it is called chronic Dysentery, or more proper by Dysentericula; this Chronic Dysentery often attends a Diarrhœa in it first and last stages - The appearances after disection - 1- no marks of disease at all - 3. A membrane formed by the lymph of the blood - 4. Pustules like the small pox - 5. Tubercles - 6. Abrasion; so as to expose the muscular coat of the intestine - 7- Gangrene; but distinguish it from ecchymosis - A 10. Sir G. Pringle found the Spleen enlarged - I have never known a Dysentery epidemic in this city - (211) 8. Contraction of the diameter, and thickening of the coats, of the intestines - 9- A diseased Liver; this is the case in India according to Dr. Tho' Clarke; but in Germany the liver was sound in every case according to [cross out] Sir. G. Pringle A It appears in the malignant inflammatory Typhoid and intermittent forms - 1 It occurs generally in high situations, where the cold would have a tendency to suppress perspiration - 2. It occurs in the Countries in which there is a great difference between the heat of the day and night - 3- It is sometimes proceeded by Catarrh, as in the Philadelphia Frigate - 4. It occurs oftener in the country [cross out] than in the city, from the city - stomachs being fortified by more cordial aliment A A In Paris in this disease; the same was the case in Vienna - (212) 5. It alternates in successive years with the yellow fever; Dr Dalzelle speaks of a putrid Dysentery in Portugal - it alternates with the bilious fever, a patient may have the bilious fever, 5 days after having a Dysentery; or even a complication of the two disease; [cross out] here bark [cross out] must be used. 6- It appears with different symtoms and is cured by different remedies; in one year, it is cured by purging, the next year by bleeding A 7- It affects the Blacks more than whites = Dr Clarke saw it go off in a salivation; it is most fatal to children and old men - 8. Sometimes it is so violent, that all ages sexes and conditions fall victims to it - 9- At Quito in S. america, a disease is described to have been epidemic; it was attended with great pain, and mortification, in the rectum; which nothing would relieve but a cut lemon A Diarrhea, transient pains in the lower bowels, sickness at stomach - A These were probably malignant dysentenies The first remedy in Dysentery is bloodletting A That this [cross out] may be the case, I need only to mention that I have seen [cross out] Dysentery to [cross out] terminate in black vomiting - (213) thrust up the rectum; this certainly was a suffocated dysentery - Premonitory Signs - These are Costiveness and small mucous & broken stools A - &c - here a purge will prevent its accession - Remedies for Dysentery - In the low state of Dysentery purges should not be given; nor vomits they have even produced death; cordials drinks and injections were the only remedies which would succeed in Chester; the drink may be made of burnt brandy and loaf sugar; it was the same at Burden town - in 1793 - A In this city the Dysentery has always been inflammatory since 1750; hence I have bled from one to 22 times in Dysentery; when we think it introverted yellow fever, remedies of the same force must be used as for yellow fever - A Dr Cleghorne always bled in this disease when preceeded by a chill; Dr Frank of Straasburg said nothing would do but bleeding A There must be [cross out] persisted in until you get fœtid green or black stools or cyballa - liquid purges are best - (214) in their dysentery; and Dr Duic, nothing but leaches to the belly - 2 In this disease lenient purges are good, such as Castor, and sweet oil, fresh melted butter, milk, vinegar and molasses, equal parts, 3 times a day; sulphur may be given for the lower bowels, but senna Rheubarb, Calomel, for the upper - In the west Indies Salt and Lime juice [cross out] are used; but both classes of purges should be helped by [cross out] laxative and demulcent [cross out] clysters; A Dr Senac recommends weak broth taken in small and frequent draughs; he says he has cured [cross out] it by large draughs of warm water alone - 3. Vomits seem to be forbidden, except in nausea; they give a centrifugal motion to the fluids of the whole body 4 Moseley recommends sweating; it should not be used; except there appear a determination of nature to the skin, or where from the climate [cross out] being uniformly warm, we suspect there is a centrifugal tendency of the system - Flax seed mullen, and mallows, tea, arrow root, a solution of gum arabic, rice boiled with water, little sugar and cinnamon Bees wax ℥ss put in Milk which has had two spoonsful of starch boiled in it - (215) Dr Sydenham recommends the following - Boil mutton Suet ℥IV in a pint of milk, while boiling add gradually some starch, with half an oz of Loaf Sugar; Pringle used the chalk Julap - it is the following - Chalk oz I to II - Gum arabic ʒii Salt Soda ʒi Mint water ℥i water oz VI - Laudanum Gts LX to C a sheet of paper boiled until dissolved in a pint of milk has been used. Blisters were first used by me, from a belief that the dysentery was nothing but a retroverted antimonal fever - The itch, or rather the consequent scratching has cured this disease; This is explained when we recollect that the skin and the bowels are antagonist muscles- Dr. Darwin tells us that two men cured themselves of this disease by fighting why not cure some of our diseases by shampooing - Opium increases or lessens the pain, Frictions upon the belly with hartshorn and laudanum, or sweet oil and laudanum to the navel; a bandage of flannel round the belly - A Dr Duic has found the distilled and fermented liquors useful, carried to such an extent as to produce slight giddyness; when these cannot be obtained; smoking tobacco is a good substitute - A In a Dropsy, in lock jaw, in Tympanitis (216) according to the propriety with which it is given - Lying on the belly and smoking tobacco has been used 3. When it is attended with a Typhoid - or Typhus pulse, you must not bleed, but gentle purges and vomits, opium and blisters must be used A - the bark seldom does good, although so proper in Typhus 4. The Intermittent Dysentery should be treated with bark, exactly as if a simple intermittent - Recollect that the remedies should be varied not only by every new occurrence of the disease, but sometimes in every individual case - Dysentery terminates in the following ways; in Rheumatism; in Opthalmia; in a Salivation; A in Dropsy; Tenesmus in chronic Diarrhœa; in chronic Dysentery; and lastly in health and death - Chronic Dysentery - This is cured by bark, by a mixture of tar wax and soap; by opium; ligatures, riding on horse back - Restlessness without pain, a streaking voice, and a sore throat - This disease is generally fatal when left to nature; and if we had nothing else to recommend Physicians than their dominion [cross out] over this disease, they would be entitled to the gratitude of Mankind - (217) when the bowels are inert; wax is good within in pills or a course powder, these pills are not dissolved, which proves they act by their indigestible quality - Signs favourable or unfavourable - If the stools, are green fœtid, or cream-coloured it is favourable, if otherwise bad; when streaked with blood it is bad; hamorrhægies generally prove fatal, streaked stools are alarming - Delirium, Hickup lying on the back, change of voice cadaverous [cross out] smell, and a sunken countenance are all bad - Dr Rush believes Dysentery to be both contagious and not according to circumstances; but I contend !!!! - that it never is read by contagion in any age or country - 3. Colera Morbus - This disease is attended with discharges both upwards and downwards, or either alone!!!; it is generally excited by cool air in the evening; Dr Sydenham speaks of the dry colera, or the discharge A But in the mild colera laudanum may be used - B This serves to distinguish it from nervous Colic - (218) of great quantities of air both up and down - I have said formerly that Diarrhœa was and increased peristaltic motion of the bowels; I now say that Dysentery is the same with spasm; and that Colera is distinguished from both, by discharges up and down - The remedies should be accommodated to the air; and the reigning epidemic; since the year 1793, bleeding has been used with advantage; opium, in the inflammatory Colera does harm A 4. Bilious Colic - 1 It is known, by its taking place, when Bilious fevers are prevalent - 2. By its being proceeded by a chilly fit - B 3. By the discharge of bile upwards and downwards - 4. By the febrile pulse; it is produced by all the exciting causes of intestinal fever - It sometimes produces intussusceptis A It often unlocked the disease, by salivation - They all relate to each other as point of danger - thus The Dysentery accords with y. fever Bil - Colic - with infla. bil. fever Colera Morbus - with the Mild vomit The Diarrhea - with inter. fever - (219) It is often epidemic through a whole country, and in Kent County Del. The remedies are bleeding purging, vomits, warm bath, and Calomel; A this last medicine, Dr Balfour give [cross out] 10 grs at bed time, and two or three times the next day - We have thus finished the 14 forms of autumnal fever - I will enumerate them - 1. The yellow fever 2 The inflam. bil. fever 3 The mild remitting fever 4. The intermitting fever 5. The chronic bil. fever 6 The Febricula 7 Diarrhœa 8. Dysentery 9 Colera Morbus 10 Bilious Colic. VII The Pulmonary States of fever - These are Pneumonia vera, notha, and biliosa; Influenza, Catarrh from the sensible qualities of the air, and Pulmonary Consumption - A The absence of cough - hence then in the progress of the disease, should cough arise it is favourable - A [cross out] the inflammation often extends through all the membrane, by the sympathy of continuity - X a sense of general weakness, slight cough - (220) 1- Pneumonia Vera - This is again divided into Pleuritis and Pneumony, but I would ask, cui bono; it is impossible to tell whether the lungs or pleura are inflamed; neither is there any necessity to know [cross out] the remedies being the same in both [cross out] cases - An Inflammation of the pleura [cross out] or lungs is known to exist by a tense or depressed pulse, pain in the side and shoulder or back, or a dull pain in the breast, increased by inspiration - A [cross out] a [cross out] - One!!! bleeding, a purge, the soap liniment or a blister will always!!! cure it - Its direct causes are transitions from heat to cold, contusions and gases; in - A direct causes, gout small pox. measles Rheumatism, yellow fever, suppression of the menses or hemorrhoids, suppressed Diarrhœa, or Dysentery and inflammation of the liver and spleen - The premonitory signs are stitch in the side; a sight chill * here 20 drops of Laudanum, or the Persons who have been thrown into water after being died, [cross out] will have the stomach full of water, and not much mucus in the Trachea, but if death takes place from drowning the trachea will be found full of mucus - (221) loss of 8 or 10 oz of blood if the pulse be active, will remove the [cross out] predisposition - The appearances after direction are - 1- A Sound, inflamed or red pleura or thickened 2- A membrane, either dense, firm, strong soft, or reticular, [cross out] and covering all or a part of the pleura - 3. The pleura connected to the lungs by a Membrane, which, when removed, discovers the pleura sound - 4. An Inflammation of the mediastinum, and intercostal muscles septum transversale pericardium and even the periosteum of the ribs themselves - The lungs sometimes exhibit no one sign of disease; and at other times, the lungs and pleura, not only appear inflamed, but sometimes the pericardium, and heart itself - this [cross out] is proved by the heart containing dissolved blood or tubercles - Remedies from all its causes - 1. Bloodletting until the pain be removed and the pulse reduced; this remedy is not regulated by stages; it is sometimes necessary in A I have in some instances bled not before the 2nd or 3rd day - B The bleeding should take place in the affected side; I recommend [cross out] this, because blood has been sizey only on one side of the body - A It has been said that a small bleeding will even do harm; this I can believe because as the pulse is depressed, the only effect of the small bleeding is to let the disease [cross out] loose upon the system - (222) all the stages; A it has been objected to because it was supposed to interrupt nature in her work of concoction, a foolish doctrine, held when medicine was in the cradle - but this is not the only instance in which we have to lament an absurb restrictions, adhered to, while the Careful doctrine which produced it, has been long exploded - B It is not so dangerous when from a wound!!! in the lungs - the first bleeding should be large to do good - A pregnant women require more bleeding; 2 lenient purges are often proper, such as Castor oil, senna, salts, and opening clysters; if there should be pain in the side, let a large blister be applied to the part, when we believe the mediastinum to be inflamed, apply it to the breast; otherwise to the back between the shoulders - Badley recommends  (223) recommends their application to the thighs 4. After depletion, diluent drinks may be taken with advantage, especially in those cases which have a centrifugal tendency; This effect may be had by adding Seneka make root to the drinks, or by giving the antimonial powders; if attended with cough dimulcents are requisite, such as barley water, and the liquorice mixture; if sufficient bleeding cannot be used to remove obstructions, which is the case at the close of a disease, then Expectorants, such as the volatile alkali, horse radish, oxymel of squills, and squills and Calomel, and vapour should be used - if the Calomel touch the mouth, so much the better; cupping between the shoulders is a good expectorant; but expectorants are never necessary, which the lancet is used properly - Emetics are excellent at the end of the disease; I have seen patients matched A Dr Sydenham has very sensibly remarked that the matters which requires expectorants, are best abstracted by [cross out] veins - 2 It ends in Hydrothorax; those having this disease once, are more subject [cross out] to it afterwards - I have attended one man 22 times in this disease - (224) from the grave by an emetic - A It ends in life with the resolution of the-[cross out] inflammation - It ends in death, from the blood vessels being surcharged with blood, from suffocation; 1 It ends in Vomica; the signs of this are partial sweats on the neck and chest - when it is near suppuration!!!, it will be well to give emetics to break it; I have never tried it, but I have known many instances of recovery; the breaking of a swing has broken one at Pittsburg, which ended in a recovery; Hippocrates recommends shaking by [cross out] by the shoulders, to produce the same effect - Symtoms favourable or unfavourable - Delirium on the 5th day is always alarming - a Diarrhœa, is unfavourable, a pain in the left side is a [cross out] worse symtom; than when on the right it is more dangerous in young children than in adults, more dangerous in pregnant women; dangerous in old people, dissolved  (225) blood is dangerous; it is favourable when the pain retreats to the arm after bleeding - 2 Pneumonia Notha - In this disease the blood vessels are so engorged with blood, as to disable them from putting on an inflammatory action; respiration is performed with difficulty; no cough attend; it is a violent and dangerous disease; it often comes on suddenly and soon proves fatal - I have called it an apoplexy of the lungs; it ends in intra-and extravasation of blood; it sometimes occurs 3 or 4 times during life; Mr Jonas Philips died of a 4th attack of it in a few hours - It seldom comes on with premonitory signs - when it does, they are drowsiness, heaviness &c- In its forming state, a few oz of blood drawn very often will prevent its formation -  (226) In this disease the following circumstances should be attended to - 1- It generally attacks those who are debilitated by autumnal diseases or labour, by hard drinking or a scantiness of food; it attacks the slaves in the west Indies; In the Southern states, it often comes on in the winter, after an attack of the autumnal bilious fever, the proceeding fall - Those who escape the bilious fever in the west Indies, are attacked by Pneumonia notha in the fall - Dr Dalzelle informs us that the Pneumonia vera is a very rare disease in the west Indies among the slaves; the gout is very very often translated to the lungs in the spring or in moist [cross out] and open winters, in which case it is generally notha, though sometimes vera - yellow fever and Influenza have both been thrown upon the lungs, when formed the remedies are, A The blisters should be applied to the sides shoulders arms and wrists at the same time - but as this is a Soap bubble disease, no sooner have we depleted than we must pour in stimulants B It is attended with sickness at stomach and vomiting of bile - (227) 1 Bleeding, even though the pulse does not indicate it; for it will rise by its use; but sometimes our patient's habit of body will forbid bloodletting; but you often change the disease to a vera by this remedy - 2. Blisters, vol. alkali Ether, Laudanum, and Mustard to the feet - A 3. The vapour of hot water, as well as the smoke of resin have done good after bleeding; I think I saved the life of a Lady by it - 3. Pneumonia Biliosa In this disease we have two morbid actions going on at the same time; B it is generally attended by a dark tongue, and takes place late in the autumn, winter or spring; when a person escapes the bilious fever in the autumn, he generally is seized by this disease in the winter; it appears It is very fatal in countries subject to the plagues; this is mentioned by Dr Webster; yellow eyes [cross out] often attend - (228) under two forms, 1st with the synochus or synocha pulse, and 2nd with the Typhus pulse - The first form is cured by bloodletting, from 3 to 4 oz; in this manner Dr Cleghorn cured this disease; but he says, the same treacherous intermissions exist that he mentioned with respect to yellow fever; these remissions I call paroxysms. The bilious Pleurisy is common in all countries subject to the plagues - 2. Purges repeated daily as in bilious fever; they should be aided by emolient clysters - 3. vomits after bloodletting, when the stomach is affected by nausea - [cross out] use demulcent drinks and opiates - Typhus form; This form, [cross out] which Dr Sydenham describes as a bilious Pleurisy forbidding bloodletting, [cross out] is known by a quick breathing, disposition to faint; the pulse will sometimes have a soap bubble tenseness - The following are the remedies A It was attended with a chill; I have occasionaly seen it so A It affects Savages, and persons who live in the coldest climates; it is a very ancient disease - (229) 1 vomits - 2 purges with clysters - now Seneka make root, opiates and bark - I have not always been equally successful in curing this disease; I have been puzzled being under the necessity sometimes of giving cordials with sizy blood - This form is sometimes chronic and sometimes acute - Bastard Pleurisy This is an inflammation of the periosteum of the ribs; and the muscles of the side bleeding is seldom necessary here; but frictions and cupping must be used - Dr Hillary mentions a kind of bastard Pleurisy in which the pain is confined to the sternum; and back A a little bleeding will cure it and local remedies - 4 Influenza - Influenza proceeds from the insensible, Catarrah from the sensible qualities of the atmosphere, they are [cross out] very much alike, both affecting the same part - This disease sometimes affects brutes; a it traversed Europe in 1801, and appear in 3 different forms in It rages in all seasons; it is not at all affected by the sensible qualities of the atmosphere, as we might have supposed from the known influence of their causes upon all other diseases - (230) France - 1 in a Slight form, so as not to prevent [illegible] 2nd just severe enough to confine the patient to his house; 3rd In a malignant form; it is often the precursor of yellow fever, and sometimes the signal of its departure; It is sometimes bilious - notha - vera - and at other times in the form of a typhus fever - It sometimes runs through jails and armies; it excited ague in those persons having it the year before according to Pringle; I have seen it local, not contagious - The remedies divides themselves into 1. Preventives and 2nd.,, Cures 1 The Preventives, are pediluvium, diluent drinks in large quantities, abstinence, bodily exertion; preaching cured it in Dr,, Whitney; he used to call it a pulpit sweat; a gentleman from New York cured his whole family by the warm bath; he called it parboiling - Dr Physick has prevented it by Laudanum in a dose of 25 drops at night - 2. When formed, bloodletting, Emetics, Blisters, gentle purges, diluents &c should be used - Sometimes the pulse * Also the feet should be protected 231 has a typhus action; here then you must use cordials - It is fatal to very old people; 12 persons above the age of 80 died of the Influenza in 1807; it is a bad affection, frequently producing Consumption - Flannels next the skin should be used to prevent catarrhs, the neck should be kept warm X a man of 96 years of age, died a few years ago, who overcome a predisposion to Consumption by putting his feet in cold water every morning; I have lately heard of a similar instance in new york - 5 Catarrh - This affection often ends in Consumption; 1st it is generally produced when the mercury suddenly falls in the Thermometer; [cross out] from 90" to 80", or from 80 to 70", more usually produces it than from 60" to 50" - hence we have the reason why Catarrhs are so uncommon in Canada and Russia, where the weather is uniformly cold, and so common in the United states and England where the climate is so variable -  (232) 1. A Catarrh is produced when air is applied to the whole body - 2. By a stream of cold air on the skin, by its sympathy with the lungs. 3. From the abstraction of a customary part of dress 4. [cross out] when applied in the shape of vapour or water, damp sheets or a damp room - In these cases, it is nothing but obstructed perspiration, thrown upon the lungs; this is generally the case in winter, but in summer it is thrown upon the bowels - but if the Obstructed perspiration be thrown upon the lungs in Summer, it shews the cause to have acted very violently, to have diverted it from its common course; hence summer, are worse than Winter colds - Circumstances which [cross out] dispose the exposure to Cold to end in Catarrh - 1- Going into the cold after sweating - 2. When we [cross out] remain in our Study a long time in cold weather. 3. By having taken a full meal, [cross out] having feasted - 4. When we are debilitated by previous labour - or evacuations - 5. A catarrh is sometimes produced by fear distress or vexation - one-fourth of all the [cross out] persons who die in some countries, are carried off by Pulmonary consumption - (233) 5. By being exposed to heat and cold at the same time, as by sitting before a fire - by going into a cold Chamber - 6 By being combined with moisture; but this does not always obtain, for in countries uniformly moist, as Holland, there are few instances of Catarrhs - Catarrhs are also produced by other causes - 1- By the miasmata of a jail - 2. By the dust arising upon the exhalation upon the removal of old books 3. By a mixture of sea and land air - 4. By the breath of persons living on luxurious food; thus Scotchmen, when they go to the little islands near them, [cross out] produce Catarrhs among the Inhabitants 6 Pulmonary Consumption - This disease is nothing but a protracted Pneumony - Its causes are either primary Secondary or sympathetic upon the lungs - The Primary causes are an half cured Preumony, badly treated Catarrh or Influenza Asthma wounds, contusions A Thrown upon the lungs; in this way the venereal poison has produced pulmonary consumption - 1st Because wounds producing abscesses, in the lungs never produce consumption for this reason that the system generally is not brought into debility - (234) and mal-conformation, irritating matters taken into the lungs The Secondary Causes are gout Rheumatism and repressed humours; A all kind of fevers - The Sympathetic causes - when the lungs are affected sympathetically with the uterus, stomach, [cross out] [cross out] 1- It is always proceeded by general debility - this proposition is proved 2nd by the sedentary lives of consumtive patients, who are either Taylors, Printers, Shoemakers &c - which neither house or ship carpenters, masons, nor Sailors or watermen (whose employments subject them to getting wet) are troubled by this disease; [cross out] 3. By the debilitating nature of the proceeding cough & 4. By its alternating with general diseases, such as Mania and Rheumatism and gout which we know to be proceeded by general debility - 4. Pus from the lungs as in Catarrh being discharged from the surface of the lungs - 5. Abscesses and Tubercles, the former on the pulmonary vessels, the latter on the bronchial vessels - no more happens here than in the diseases of the liver, spleen and head!!!; Thus it is perceived that it is absurd to consider those circumstances or causes of disease in pulmonary consumption, which are admitted to be effect of disease everywhere else!!! - (235) and why should we suppose an abscess in the liver to be the effect of Hepatitis, and consider its as the cause of a diseased lungs - Sometimes the disease comes on without premonitory symptoms - 6 In some cases Hydatids are formed, but oftener Calculi have been discharged but the same matters are produced by disease else where - But why should excitement be thrown upon that part in preference to any other? the answer is because it is a flaccid viscus, being constantly exposed to predisposing debility, from exposure to all weathers - sometimes the super abundant excitement is thrown upon the Trachea; which constitutes what I would call a Tracheal Consumption; this is not fatal, although it has existed [cross out] for 60 years; the reason patients survive is because the disease is insulated. 3 Sometimes it assumes an intermediate [cross out] state, between Pneumonia and Pneumonicula and kills in 6 weeks; this called a Galloping Consumption 4. It generally takes place under 36, sometimes above A It is said to follow the predisposition of the father rather than the mother - (236) 45, but rarely above 60; between 19 and 21, when we cease growing, consumptions will come on - 1st an account of a redundancy of blood; 2nd From the absorption of the Thymous gland, and 3rd. From a narrow chest - There are but few cases of this disease in childhood, yet it has been induced by whooping cough, but the Thymous gland generally protects this tender age - 5. It generally occurs in persons with black eyes or red hair; it is often hereditary; A but yet there are many instances in which it is a filial disease; The same is the case with Epilepsy Sore Cys and Deafness - 7- Moist and variable climates, when near the seashore are apt to produce consumption; when the place is not situated near the sea, variableness, and not moisture, predispose to this disease; that moisture does not produce it I infer, from its being unknown in Holland and some parts of Ireland - cold and hot climates have few consumptions, but they are not favourable to them A Dr Blaine believes that countries between the 30th and 40th degree of latitude are most frequently to consumptive patients - I agree with him - (237) when formed A 8th- One half or at least 1/4 of all who die in England die of this disease - In Salem Mass. 1/3 the deaths are consumption, now Salem is near the sea there 9. Consumption has been divided into stages, but they should be called states; they are the inflammatory hectic and Typhus - But they dont succeed in this order; I have had anomalous cases -2 I have seen two instances without fever or night sweats -3 I have seen an instance without a cough fever or night sweats - 10 Consumption is said to be contagious; it may be Communicated by the contagion of excretions [cross out] or by the breath from ulcers in the lungs; it is true that the idea of contagiousness is so fixed in Spain, as to induce them to burn the bed cloaths of consumptive patients; but the same is done in yellow fever upon the same high medical authority, without proving [cross out] the latter to be contagious; it will not be said that its being a filial disease proves it to be contagious because it proves A The discharges from the bowels and Uterus go on regularly; the sexual appetite remains unimpaired - A Both of which grades of fever produce dryness of the tongue; that this is the explanation I infer from Mania being attended with a moist tongue - (238) too much, it would prove that deafness, sore Legs and Epilepsy were contagious - This disease is difficult to cure, owing to its being insulated, for you will find your patient well every where but in the lungs; the Uterus is not affected, the muscles!!!, very little, there is no headach; often a good appetite; A I say the strength is but little affected; because the blood vessels rob the muscles of some of their excitement - The tongue is generally moist - this arises either from 1. the preternatural vapour from an abscess, or 2. It may depend upon that intermediate grade of fever, between Synocha and Typhus; A it is the same with Mania; and this reason is made likely from the tongue becoming dry in consumption and Mania when the system takes on the Typhus grade - The colour of the tongue arises from the species of exhalation from the stomach, it is either yellow, black or green; these appearances are all derived from bile; thus I reject A These tubercles are often suddenly formed (239) the opinion, [cross out] that it is a morbid secretion within the mouth, as Dr Darwin supposed from the gums and teeth sometimes putting on the same appearance - The following are the Appearances after death - 1. no appearance of disease at all - 2 Sympathetic!!! swellings, such as polype!!! and membranes - 3. Tubercles; 4/5 the of the fatal cases of consumption arise from Tubercles; A they are sometimes in a scirrhus state - They are not the cause, (as is believed in England) but the effect of Consumption - 4. One or more abscess - either open or confined - 5. One or more superficial ulcers, thought to be cancerous; sometimes they exist on the Trachea - 6. Water in the substance of the lungs, also Hydatids - 7. Pus secreted by the Pleura - 8. Chalky silicious and gravelly substances - 9 Ossification of the pleura and lungs - In one instance I have from the [cross out] right lung entirely removed by disease; it was a case of anomalous pnuemony which came on which the patient was under treatment in hospital for a mortification of both feet from coagulation, the affection of the chest came on with vast difficulty of breathing, which was soon followed by a purplish - red flush of the face and neck; seeming to indicate an imperfect oxygenation or decarbonation of the blood; the pulse was very soft, but not small, and tolerably slow; but the action of the heart, as ascertained by placing the panel upon the chest, was hurried and violent beyond measure; the case soon puzzling which induced me to consult my mates; (240) 10 Matters which have been inhaled, such as flour, flannel or flax &c - 11- Preternatural size or weight - 12. Preternatural lightness - 13. Of the hardness of smoked meat - 14. One lobe entirely gone - The left lung is more liable to be morbidly affected - All these appearances are the effect of a primary disease in the blood vessels - I believe this disease would not be so fatal were it not for the hectic fever, which so invariably accompanies it; if there be no fever, there is not much danger, for the lungs are a hardy viscus - even cancers are not dangerous until they produce fever, unless they corrode some important vein; so it would seem that the blood vessels are not only the outposts, but also the citadel of the system - they are the last retreat of vitality - Sometimes death is produced without Hectic fever - The [cross out] remedies of consumption are divided into two I suggested the propriety of trying bloodletting to very considerable extent as the only chance of saving the life of the patient; they did not approve of the preposition, and I dropped the remedy; [cross out] they were opposed to it on account of the apparent dying condition of the patient from the circumstance of his mortified feet and his being a notorious drunkard, there were strong objections and they staggered on- Upon direction as I have said the right lung was formed wanting, [7- The cold or warm bath] - and the cavity of the thorax on that side was 1/3rd filled with pus - this showed that the violent action of heart arise, from the occurrence of pneumonic inflammation under circumstances of the pulmonary system, so very unfavourable for the transmission of blood; there being (241) kinds, 1. such as are proper in the forming states - 2. Such - as are proper in the formed state of the disease - 1 Remedies for the forming State Here the symtoms are flushing, sense of fatigue, hot hands and feet, a tense pulse - The remedies are 1- Bloodletting if the pulse be pale or tense 2. Cold bath and Tonics, as tar; bark of aliments, Salt meat, salt fish and eggs with beer or a little Porter and water 3. Exercise on horse back or in a carriage - 4, Change of air - 5- Rest- if produced by fatigue or labour - 6- Removing the exciting cause - It is thus I have strangled many consumptions in their forming state. Some pretend there is no Consumption where there is no pus - but this is an error, [cross out] have cured as well as lost many patients in consumptions not attended with pus - in the same manner it was insisted upon that there but one lung hence the same quantity of blood which in what was comparatively speaking health at with difficulty transmitted, became overwelming when altered and accellerated by disease and inflammation - A we never act so in curing moral diseases, we punish folly to prevent vice and punish vice to prevent crime This Soldier died in 12 or 15 hours [cross out] after the accession of the chest affection, how he was enabled to enjoy tolerable health, and perform his duty 1 in the ranks before his attack I am at a loss to explain; but surely the lung which was found absent must have been destroyed by very slow degrees in order to allow it time to the system to accommodate itself to so great a derangement - T.K. (242) could be no yellow fever without a black vomits - Of all diseases, beware of applying nosological signs to this; for what can be so ridiculous as to let a terrible disease gain a strong hold of the system, in order to give it time to devellop itself into its genesis and species instead of resting on it at once, with all the power of medicine A - But we have other premonitory symtoms, such as tightness of breast; this symptom has existed 18 months without confining the person - Consumptions are either synocha Hectic or Typhus; but they do not always occur in the order here laid down - The Synocha State of Consumption 1 Here small and frequent bleedings are indicated; leriah Tracey, formerly a member of congress, was cured by 96 bleedings; and Dr Griffiths effected a cure in a young lady of this city by 130 bleedings in 18 months - 2. nitre in doses of 10 to 20 grains 3 times a day. A But by not [cross out] telling us the exact time it which they are indicated; his advice has done much harm; they are most proper when the disease arises from catarrh or when the pulse is a little above par - Blisters are good they should be applied between the shoulders if from the common causes; but if it arises from gout or Rheumatism the blisters should be applied to the joints - (243) 3 Vomits; Dr Reid recommends them A - 4. Purges; This hint I took from nature, who sometimes brings on a Diarrhœa, but generally too late; as she brings on hæmorrhagy in yellow fever. let us therefore not follow nature but go before her by inducing an artificial diarrhœa; the purges should be sulphur Salts castor oil - The next remedy is a vegetable diet with Salt meat, but not more than a pint of fluid should be taken in a day, for although it might not strengthen, it would fill the blood vessels - Milk has been used, but it is not proper in the synocha state of consumption, except to blunt the humours from abscess - but if the patient be bent upon having milk, prescribe Buttermilk or whey both of which are less nourishing than milk recollect my expeditions mode of making Rennet whey - Salivations act by revulsion, and remove obstructions; this is a radical remedy; of 36 persons, who died of consumption, one half had enlarged spleens; from this we infer A We often see nature in the latter stages of the disease try to relieve himself by dropsical swellings; may not the efficacy of arsenic when given early depend upon its anticipating this effort by of nature, by producing dropsy? - (244) that spitting of blood does not forbid this remedy; I shall tell you hereafter that spitting of blood depends upon an enlarged spleen!!! - but recollect that even where Mercury - comes, it cannot remove the predisposing debility, for which are Tonics to be mentioned directly - The Hectic State of Consumption Within the last year I have begun to use Arsenic here, to produce a centrifugal effect, for as we see nature sweating herself, let us anticipate her, and bring on sweating some A - Small and frequent bleedings will be of service - The Typhus State of Consumption - Here you must use stimulants; the efficacy of opium was discovered by accident; it acts probably by throwing the disease upon the head, and thereby giving a respite to the lungs; in most cases we are too tender with the brain, [cross out] be assured it can bear a great deal; this is proved by the circumstance that Drunkards retain their intellects frequently after habitual excess is for a member Tar 10 grs 3 times a day - or tar water A By combining the effect of all these stimulating remedies - (245) of years - Tobacco has been of service when the saliva is swallowed, but I would not recommend it; 3 eggs with their skills dissolved in a pint of vinegar a wine glass 3 times a day has hour of service - Bark has been used, but it never does good but in the shape of Huxom's Tincture; and here the Spirits may do all the good; garlic and Tar are good; the disagreeable taste if Garlic may be removed by honey; Tar does most good when taken in substance now cordial food, and milk, if liked, should be given as also fresh Malaga [cross out] grapes, roasted apples; ardent spirits in the shape of grog and Toddy; milk punch, porter &c - I have been, within these few years, successful in 5 instances in the hospital; A [cross out] mercury [cross out] given here just to touch the mouth, but in Typhus we can seldom excite a Salivation, and if we do we mostly do harm; we sometimes hear of patients recovering after having been deserted by their Physicians, this arises from their returning to their healthy nourishing diet - Frictions are good in this state, from the inverse sympathy between The frictions should be made to all parts of the body, but especially to the arms and legs. The hardships of a camp naval or agricultural life have often cured a consumption - (246) the lungs and skin; shampooing perhaps might act in this way; volatile liniment will render the frictions more efficacious; exercise may be used in the Typhus state, it either of the passive or active kind; but in the inflammatory stage, only the passive is required; but in either case to do good it must be constant and not that kind [cross out] the patient has been accustomed to Do not allow your patients to go to the sea-shore unless in the Typhus stage - Labour is often very good; Shuttle cock, swinging by the hands, rowing, jumping the rope, and all exercises, which employ the arms and legs are very good - Change of climate to one which is neither hot nor cold is good such as Barbadoes or Portugal; this effect may be obtained by flying from the winters of the [cross out] northern states, and from the Summers of the Southern; this mode has the advantage of combining travelling with your being in a temperate climate. Dr Harison remarked that no Consumptions took A And also those who came there already with the disease are generally cured, should they be seized with a bilious fever - 1- A milk diet - transfusion has been attempted from lambs &c the same mild state of the blood is produced by milk - (247) place in the marshy ferns of Linconshire A nor in Holland since last year I have gotten two letters [cross out] of persons, cured of Consumption by going to Ostend Marsh Miasmata not only cures but prevents the disease - But if neither travelling nor migration are practicable, then by hybernate your patients in a stove room; but in this case you must not allow them to have the room the whole winter; it is said that an attack of the bilious fever will cure the disease sometimes; we know that hemoptisis has been cured by fever; I have known more than once an intermittent to be destroyed by a bilious fever Other Remedies 2 Sweet food has cured this disease; I think I cured Consumption by Malaga grapes - [cross out] 3 It has been cured by eating sweet apples, or also by eating bread and butter with Sugar - 4 It has been cured by large draughs of the juice of In a disease, from which death is in turn if left to itself, it is not only proper to give uncertain remedies, but it is criminal not to employ them; Consumption has been cured more than once from a Pneumony supervening (248) the maple - 5 Issues have been recommended; I have known a cure in one instance - Dr _ says they should be made under the arm pits, because some consumptions have terminated in that way; but I think a blister is a good substitute (on the left arm, being less used) because it is less contrary to the prejudices of [cross out] our patients - 7. Digitalis has been used, but I have no opinion of it; it lessens the force of the pulse, it is certain; but we know opium lessens the pulse!!!, but who would give this in Consumption!!! 6 Fumigations of resin, tar and brandy, heated and inhaled; a cow-stable - The camp or agricultural life - also Diuretic remedies, as the nitrous powders and squills; but when you give these remedies you should recollect whether the cause be primary or sympathetic; if it be sympathetic, try to bring on the original A Salivation has been used with success if disorganization has not already taken place in the lungs; we need not be alarmed should a spitting of blood be the consequence for this is often an attendant upon a diseased spleen, which disease often takes place in Consumption; thus Mr Praust found our half of the spleen of a number of patients he examined after death from consumption to be greatly enlarged - (249) disease 10. your patient should not be suffered to indulge in venery- if you advise a married man to travel, forbid his wife to accompanying him; the same restriction is applicable to women - There is an amazing sympathy between the lungs and the venereal appetite; I knew a gentleman, who declared to me that he always spat blood after a venereal connection with his wife; and Gay-Lussac declares that those cows that die from being deprived of intercourse [cross out] with the male, always have diseased!!! lungs - The venereal appetite continues in females in this disease, hence their Catamenia continues, and thus it is that bearing numerous children will often keep Consumption at bay by its greater counteracting Stimulus - Two remedies have been used lately, the Lichen Icelandicus, and the Alcornoque; they are mucilaginous and A The remedies are 1st Arsenic in pills or Solution (250) somewhat bitter - As well might we attempt to demollish the rock of Gibraltar by a Musket Shot, as to cure this formadable disease by such paltry remedies - Paliatives And 1st For the cough; this is either at night or during the day, or both night and day - To allay it gives anodynes about six O'Clock in the evening, this undoubtedly is the best time, however you will explain it, it may be necessary to give an anodyne early in the morning, according to Dr Sydenham - 2. To mitigate [cross out] sweats which arise from debility and which happen at night from the centrifugal action, which takes place at that time, A you must require sleeping on a Matrass and wearing flannel, brine, a pint of Lime water taken in a day - watter [cross out] mellons, and lastly a shirt dipped in a decoction of bark and dryed; and worn bloodletting when the pulse is excited never fails to check it; a Diarrhœa often takes place near the close The remedies Laudanum chalk [cross out] gum Kino - 1 Profuse sweats Diarrhea and faulted legs - this is the common termination - (251) of this disease; and then the moist sweats and cough cease; but it comes too late to do good; let us therefore anticipate nature, and bring on a Diarrhœa in a more early [cross out] stage of the disease: 3. General pain may be relieved by bloodletting Death is produced in the following ways- 2 By the sudden bursting of an abscess - 3. By a rupture of a blood vessel - 4 By suffocation from water - 5. By the translation of the disease to the head producing madness - 6. By a sore throat 7. By Pneumonia synocha or congesta Lastly a Diarrhœa and lasting night sweats - Some Remarks 1. Consumption when arising from Ancestors is very unfavourable - 2. When from Gout, it is unfavourable - a Spitting of blood after the cough has ceased is unfavourable - (252) 3. When there are Calcui, I never knew a recovery - But this year heard of one - 4. When the cough suddenly ceases, unless Diarrhœa or Madness supervene, it is a bad sign - 6 When the expectoration is water, the patient seldom recovers 7 When the eyes change their colour, it is very unfavourable, and the teeth becoming white 8. Lice and Depilation is very unfavourable - 9. I never knew a recovery after a swelled face 10 When from repelled eruptions, it is generally fatal 11- When from old ulcers, it is unfavourable - Spitting of blood is favourable in the beginning but unfavourable towards the close of the disease, a Constant vomiting is a bad sign. Do inference can be drawn by examining the expectoration; Thousands have been cured with It is a symptoms of consumption or a local disease - A Too light bed-cloaths at night - (253) pus, and thousands have died without it - It will be well to meet the disease in its forming state by cordial aliment and drinks; bleeding and bark, as also frequent bleedings more especially where Congestions are indicated; in this way you may often keep the disease at bay - As for the Preventives, long journies, change of climate and removal from the vicinity of the Seashore, should be resorted to - Cough I shall now give you some remedies for Cough, contradistinguished from Catarrh, by being unattended by fever; it is either pulmonic or Tracheal Its causes are direct indirect and sympathetic; its direct causes are a current of air, A excess in eating or drinking loud speaking &c. it is often produced by fear and is known by a short cough - sweet oil - Lime juice or vinegar, honey or molasses, each equal parts; and if the pulse will bear it spirits may be added - A Stem them together for an hour or two (254) The remedies should be regulated by the state of pulse and system; if the patient be plethoric, bleeding or requisite, and abstinence; when the pulse is not active, bathing the feet every [cross out] morning in cold water will be found of service; it has been cured by long journies, frequent draughs of cold water - standing against a wall has stopped a paroxysm of cough; opium has done good, [cross out] the Liquorice mixture [cross out]; the horse radish sirup is only proper for hoarseness, it is recommended by Dr Cullen - In a Languid state of the system, use a mixture of Elecampane Hyssop and Hoar hound, each a handful in a gallon of water; boil it down to half a gallon, and add one pound of stoned raisins, A then add 2 drams of liquorice, and 2 pounds of Loaf Sugar; now boil it down to a sirup -  (255)  (256) A Page Arteries; cases in which they do not sympathize - 97 Affusion, as a remedy for fever - 127 Ablution as a remedy for fever - 130 Abstinence as a remedy for fever - 132 Alkali, volatile, as a remedy for fever - 147 Air pure, as a remedy for fever - 152 Aliment in fever, rules for giving - 156 Autumnal fever; its 10 forms - 219 B Blisters or Evacuants - 42 Blisters, rules for the use of - 42 Blisters perpetual, the best issues - 45 Baths as Tonics - 58  (257) Bloodletting, as a remedy for fever - 115 Blisters, as a remedy for fever - 125 Body; signs taken from it in Fever - 173 Bilious fever, autumnal, 6 forms of - 184 Bilious fever, inflamatory - 187 Bilious fever, mild - 187 Bilious fever, chronic - 195 Burning State of fever - 205 Bilious Cholic - 218 C Choice of medicines - 12 Consultations - 14 Cathartics, as an evacuant in fever - 27 Cathartics, Rules for their exhibition - 28 Changing Climate, Rules for - 67 Clysters as an evacuant in fever - 30  (258) Classification of Diseases Brown's, rejected - 89 Clysters as a remedy for fever - 121 Convalescence from fever; Treatment proper during - 163 Critical days - 168 Countenance, signs taken from - 175 Chilly State of fever - 205 Colera Morbus - 217 Catarrh - 231 Cough - 253 D Diseases, which are incurable - 6 Diseases, which it is unsafe to cure - 6 Diaphoretics - 31 Diaphoretics when indicated - 33 Diuretics - 34 Division of diseases, Darwin's rejected - 89  (259) Division of diseases, Rushis - 90 Depression, how caused - 96 Diluents, such as are proper in fever - 133 Diarrhœa, the acute form - 206 Dysentary - 207 Dysentary; premonitory signs and remedies of - 213 Dysentary, chronic - 216 Dysentary, signs favourable, or unfavourable in - 217 E Excitement, grades of - 16 Excitement, how to ascertain the state of - 17 Emetics - 23 Emetics, Rules for the exhibition of - 25 Expectorants - 36  (260) Emmenagogues - 36 Errhines - 42 Exercise as a Tonic - 60 Electricity as a Tonic - 67 Excitability, how accumulated - 95 Extinguishing fever, means of - 111 Emetics, as a remedy for fever - 118 Errors bulgar, respecting fever - 139 Emotions, invigorating, as a remedy for fever - 154 Excretions Signs taken from - 177 F Fevers, always proceeded by general debility - 92 Fever, causes which dispose to - 94 Fevers, in what they end - 100  (261) Fever, different states of - 102 Formation of fever; remedies for its prevention - 105 Fever - premonitory signs of -105 Fevers, remedies for - 115 Fevers, treatment of, cautions to be observed in the - 159 Febricula - 195 Fainting State of fever - 204 G Gavalnism as a Tonic - 67 H Heat, Stimulus of, remedies abstracting the - 125 Hectic fever, Theory of the formation of - 180 Hectic fever, the remedies for - 182 Hectic fever; Some questions on its cure - 183 Hydrophobic State of Fever - 199  (262) I Issues - 44 Issues, when indicated - 44 Inflamation; what it depends upon - 100 Infusion; as a remedy for fever - 129 Intermittent fever - 206 Influenza - 229 L Longevity; means of promoting - 76 M Mixture of Medicines - 13 Mercury, means of obviating the effects of - 39 Mercury, when useful - 40  (263) Mercury, when forbidden - 41 Mineral waters - 59 Mind, pleasures of, as a Tonic - 67 Medicines as Tonics - 68 Medicines, which act by removing redundant matters - 72 Medicines, which act by mixing with the offending matter - 72 Medicines, sweating, as a remedy for fever - 122 Malt Liquors, as remedies for fevers - 146 Mercury, as a remedy for fever - 152 Moon; its influence upon fevers - 169 Muscles, signs taken from the - 175 Mind, signs taken from the - 179 Mercury fever - 198 N Nature, operations of, in curing fevers - 8 Nosology rejected - 79  (264) Nerves signs taken from the - 176 O Oils, empyreumatic, as remedies for fever - 148 Oils, aromatic, as remedies for fever - 148 Opium, as a remedy for fever - 148 Opium; rules for its exhibition - 150 Oxygen gas, as a remedy for fever - 154 Opium fever - 197 P Preparing medicines, some rules for [cross out] - 15 Pain, remedies for the relief of - 73 Practice of Physic - 79 Phenomena of fever - 91  (265) Purges as a remedy for fever - 119 Passions, invigorating, the abstraction of the; as a remedy for fever - 132 Passions, invigorating, as a remedy for fever - 154 Prognosis of fever - 170 Plague, remarks on the - 195 Poisons, fevers produced by-205 Petechial state of fever - 206 Pulmonary states of fever - 219 Pneumonia vera, described - 220 Pneumonia bera, the remedies for - 221 Pneumonia notha, - 225 Pneumonia Biliosa - 227 Pleurisy Bastard - 229 Pulmonary Consumption - 233 Pulmonary Consumption; appearances after death from - 239 Pulmonary Consumption, remedies for the forming state of - 241  (266) Pulmonary Consumption, remedies for the synocha state of - 242 Pulmonary Consumption, remedies for the hectic state of - 244 Pulmonary Consumption, remedies for the Typhus state of - 244 Pulmonary Consumption, Paliatives to be used in - 250 Pulmonary Consumption; how is death produced in 251 Pulmonary Consumption, general remarks on - 251 R Reaction, how caused - 96 Respiration, signs taken from the - 177 Remarks, general, on fever - 184 S Specific remedies - 7 Sedatives, the manner of acting of - 18  (267) Sedatives direct - 19 Sedatives, indirect - 22 Sillagogues - 37 Salivation, what renders it more certain - 38 Stimulating remedies - 46 Stimulating remedies, rules for the exhibition of - 48 Stimulants, their Modus operandi - 52 Senses, pleasures of, as a Tonic - 67 Surgical operations - 76 Signs, premonitory, of fever - 105 Suppositories, as a remedy for fever - 122 Sillagogues as a remedy for fever - 124 Sedatives, translating - 136 Stimulants, such as are proper for fever - 145 Spirits, as a remedy for fever - 147 Substances, fœtid, as a remedy for fever - 148 Stimulants, external, as a remedy for fever - 156 Senses, signs taken from the Senses - 176  (268) Secretions signs taken from - 177 Sweating state of fever - 204 T Therapeutics - 1 Tendency of nature, advantage of observing the - 10 Translation, as a means of lessening Morbid excitement - 53 Tonics Rules for the exhibition of - 55 Travelling, rules for - 65 Tonics, how they act - 70 Typhoid state of fever - 138 Typhus state of fever - 139 Typhoid fever, remedies for the - 142 Typhus fever, remedies for the - 143 Tongue, signs taken from the - 174 Tenesmus - 208 V Visible parts, signs taken from - 174 Vomiting, means of preventing - 186  (269) W Wine, as a remedy for fever - 146 Y Yellow fever described - 185  270  271  272  273  274 End of Vol 2nd 275  276