JSr.y sk-tv ! '• .:v> ;■•;■-, [., . ---,l-»''ij '. -," ■■<:-. • •;- •. r-,- .,,"..' S-- . : .'.r4-'^v^-;>-;•-.•(•■.•-,',;-'- ;•■ r '■ .» S' ' * ■ 'ii2T*E^"2 ■ V '•''': '.V'.i '.,•—'• •■'■ vi ;-n V- ■„> SJaMi*»i;'lfr'-;,''f'i:'.V;..^ ,1./? • <; .('»* =;..i^22fcKr5v-':rl^ .n> *.,•■■ • ■ • ■•■:.■ i "••-'■• J :vr^«S:i*! J.:;t:';:-;;r';'X:':■ !>-, ^;"&^>i^,'-; .;»'•• ■■■■■ :■; • . p^••r^^^^;^;'i'^i-^•, ■.'.■■■..•:■ L:-:V-^:!»^.-;;r-,;,-;::-;-i-''■■■.'■ 7-!: .■' .. ''■'^^"^^^ ;.J. v;;, !'.;::':■•■. :/"' -?i.^!rt;J •.'."'•-!■■'.' ■'••■'' '';':'':.: v.,/ ■' ■ ^vLJJ/% If V THE ED INBVRGHA NEW DISPENSATORY: CONTAINING, I. The Elements of % History of the different Pharmaceutica l.'I Substances employed in Chemistry. •' 9 Medicine. II. The Materia Medi-'?III. The Pharmacedti- c a ; or, the Natural,Phar- / calPreparations maceutical and Medical } and Compositions; © INCLUDING COMPLETE AND. ACCURATE TRANSLATIONS Octavo Edition of the London Pharmacopoeia, published in 1791 $ Dublin Pharmacopoeia, published in 1794; and of the New Edition of the Edinburgh Pharmaco- poeia, published in 1803. Illustrated and Explained in the Language and accotmng* to^e Principles of Modern" Chemistry WITH MANY NEW and USEFUL TABLES, s£§ Several Copperplates, explaining the New System of CHEM- ICAL CHARACTERS, and reprefenting the moftufe- ful PHARMACEUTICAL APPARATUS. *3&&&c>< By ANDREW DUNCAN, Jun. M. D. ELLOW OF THE R8YAL COLLEGE OF PHY S I C I AHS, AN D ROYAL SOCIET EDINGBUR.CH, AND ASSOCIATE OF THE LINNiEAN SOCIETY IN LONDON FIRST WORCESTER EDITION. fir WORCLSTEH : FROM THE PRESS OF ISAIAH THOMAS, JUN. Said by him ia Worcuter & Springfield. ; also by Thomas & Andrews, Boitorij and by Thomas (3 Whiffle, Newburyport, July—1805. 0 £ * ■ TO ANDREW DUNCAN, M. D. PROFESSOR OF THE INSTITUTIONS OF MEDICINE IN THE UNIVERSITY OF EDINBURGH, THIS WORK. I s MOST DUTIFULLY A N L> AFFECTIONATELY INSCRIBED BY HIS SON, »©«!&» Directions to the Bookbinder* Plate I. to front p. 110. IE in. HI. 112. IV. 113. V. 114. VI. 118. .$>&G), PREFACE. 1~)r. LEWIS publifhed the firft edition of his New Dispensa- tory in 1753. The principal part of the work was a Commentary upqn the London and Edinburgh Pharmacopoeias, of both of which it contained a complete and accurate translation. A concife fyftem of the Theory and PraCtice of Pharmacy was prefixed, as an introduction ; and directions for extemporaneous prefcription, with many elegant examples, and a collection of efficacious bat cheap remedies, for the ufe of the poor, were added as an Appendix. The manner in which the whole was executed, placed Dr. Lewis at the head of the reformers of Chemical Pharmacy ; for he contributed more than any of his predeceflbrs to improve that fcience, both by the judicious Criticifm with which he combated the erroneous opinions prevalent in his time and by the actual and important additions he made to that branch of our knowledge. He was juftly rewarded by the decided approbation of the public. During the Author's lifetime maay editions were published, each fucceeding one being improved as the advancement of the fciences con- nected with Pharmacy fuggefted improvements. After the death of Dr. Lewis ; Dr. Webster, Dr. Duncan, and Dr. Rotheram, fucceffively contributed to maintain the reputation of the work, by taking advantage of the dileoveries made in Natural Hiftory and Chemiftry, and by making thofe alterations which new editions of the Phar- macopoeias, on which it was founded, rendered necelfary. From the place of their publication, and to diftinguifh them from the original work of Dr. Lewis, which was ftill reprinted in London, thefe improved editions were entitled, " The Edinburgh New Dispensatory." When the Edinburgh College fome time ago determined to publifti a new edition of their Pharmacopoeia, the bookfellers who purchaled the copy right of that work being defirous that it fliould be accompanied by a correfponding edition of the Edinburgh New Difpenfatory, applied to the prefent Editor to make the neceflary alterations. This he readilyoinder- took, and the number of the alterations made will ftiew, that if he has «ot fulfilled what was expeCted from him, it has been owing to want of ability, and not to want of exertion. . . The general plan of the work remains the fame. It is divided into three parts. The firft contains Elements of Pharmacy ; the fecond, the Materia Medica ; and the laft, the Preparations and Compoiitions. The firft of thefe is entirely new, nothing being retained but the title. It is divided into two feftions. The firft contains a very concife account of fome of the general doctrines of Chemiftry, and of the properties of all am- ple bodies, and the generic characters of compound bodies. In the fecond part, the Operations of Pharmacy, and the neceflary apparatus, aredefenb- ed ; and an Appendix is added, containing many very ufeful Tables, and the Explanation of the Plates. We now poflefs fo many excellent elementary works on Chemiftry, both tranflations, and original works, fuchas thole of Dr. Thomson, Mr.MuR- ray and Mr Nicholson, that it is perhaps neceflary toexplainwhy we have introduced an epitome of Chemiftry into this work. But its introduction is not only authorifed by the example of former editions, and in attempt- in" to explain in a fcieatific manner the operations 01 Pharmacy, we found ourfelves fo frequently obliged to mention the general principles and faCts of Chemiftry, that, to avoid tedious repetition*; it became neceflary either A VI PREFACE. to refer to fome elementary book already publifhed, or to affix to this ivc;k a fhort abflraCt of Chemical Science. The latter alternative was ptefened, as it would torm a bond of connexion between the detached fubjeCts treat- ed of in the other parts of the work, and as it appeared, that, by meansof a due attention to arrangement, and by rejecting hypothetical reafoninej, a very few pages would be fufficient to contain a valuable collection of the facts afcertained with regard to the fimple bodies, and the generic charac- ters of compound, which would enable us to explain the properties of the fpecies employed in medicine with more facility to ourfelves, and with more advantage to our readers. Long after this part was ready for the prefs, Mr. Davy's Syllabus was publifhed, and we were agreeably flattered to find, tlvat befides the fame general arrangement, we had often taken the fame view of the fame fubjefts. This fimilarity enabled us on feveral occa- sions to profit by Mr. Davy's Syllabus during the printing of the meets. The principal addition to the fecond and third parts of this work is the introduction of a complete tranflation of the excellent Pharmacopoeia of the Dublin College, which has never, we believe, appeared before in the En- glifh language. We therefore truft, that it will be found an important and valuable addition. The fecond fart contains the Materia Medica, arranged in alphabetical order. The alterations in this part are alfo very conliderable. We have adopted the Nomenclature of the Edinburgh College, or rather of Natural Hiftory, in preference to the officinal names hitherto employed. To the fyflematic name of each article, are fubjoined its fynonimes in the different Pharmacopoeias, and the defignations of the parts ufed in medicine ; then the clafs and order of natural bodies to which it belongs, and if a vegetable the exaC't number of its genus and fpecies, according to the excellent edi- tion of Linnjeus's Species Plantarum,novf publifhing at Berlin by profeflbr Willdenow. In other particulars, conliderable additions have been made to the Nat- ural Hiftory of the different articles, to the means of diftinguifhing them from other fubftances with which they are apt to be confounded, and of de- tecting frauds and adulterations. Almoft every thing which regards their Chemiftry is entirely new. As from the principal lift every article has been-excluded which is not contained in the Materia Medica of at leaft one of the Britifh Colleges, we have given in an Appendix a very concife ac- count of fuch other articles as poflefs a place in fome refpeCtable foreign Pharmacopoeias ; but we have to exprefs our regret, that notwithftanding repeated attempts, we have never been able to procure the lali edition of the Pruflian Pharnracopoeia, publifhed at Berlin in 1799. ^e have alfo added lifts of the Medicinal Simples, arranged according to the beft fyftems of Natural Hiftory. The third part contains the Preparations and Compofiticns. In our general arrangement of thefe, we have not followed any of the Colleges exaCtly, although we have not deviated much from that of the Dublin Pharmacopoeia. It is not of very great importance in what order the clafles or chapters be arranged ; but thefe clafles fhould be natural and, if pofliblc, eftablifhed on one general principle. Unfortunately how- ever, in moft Pharmacopoeias, fome of the clafles are founded on Chemical Analogy, and others on the fimilarity of form, or mode of preparation • and what is ftill worfe, fome are entirely anomalous and unnatural. The laft error we have carefully endeavored to avoid, but we have not attempt- ed, and, indeed, it feems fcarcely poflible to form an ufeful arrangement" on a fingle principle. The analogous preparations in the different Phar- macopoeias, arc always placed immediately next each other, which renders it eafy to compare them, and to difcover at once the circumftances C\ which they referable or differ from each other. PREFACE. nj The Commentaries upon this rait, are more or lefs full, as the fubjed feemed to be more or lefs important. Little alteration has been made in the obfervations upon their medical powers, becaufe thefe we-re generally riie refult of more practical experience than v\ e poflefs, and becaufe this Difpcnfatory is to be confidered rather as a pharmaceutical than a pr; Cti- cal expofition of the Brir.fh Pharmacopoeias. At cne time it was alfo in- tended to have inferted example: of extemporaneous prefcription, with ob- fervations ; but it would have extended the work too much beyond its ufual limits; and fortunately the latter deficiency is well fupplied by theThe- faurus Medicaminum, and the former by the practical Synopfisof the Ma- teria Alimentaria et Medica, and by Dr. Cullen's claffical work. During the progrefs of this publication, all the beft Journals and fyftems of Chemiftry, particularly Fourcroy's Syftcme des Connaiffances Cbimi- ques, have been occafionally confulted, for chemical information. But we lie under more immediate obligations to fome of the German writers en Pharmacy, fuch as Hagen', Hermbstaedt, Gottung, Gren and Westrumb. The writings of the French Chemifts, alfo contain detached pharmaceutical faCts ; but it is not a little remarkable, that a nation which has publifhed the beft fyftems of Chemiftry, fhould not have produced afin- gle elementary work on Pharmacy that is not below mediocrity. e THE ancient praCtice of naming medicines from their inventors, or fup- Eofed virtues, has been for fome time exploded from our Pharmacopoeias; ut it has been long cuftomary to defcribe both fimple fubftarces and their preparations or compofitions by what are generaljy termed Officinal Names in contradiftinCtion to the prefent fyftematic names of the fame fubftances. But their officinal names are in fact the old fyftematic names, which vers unaccountably retained for the denomination of medicinal fubftances, after the improvements in Natural Hiftory and Chemiftry rendered the intro- duction of a new nomenclature into thefe fciences neceflary. Attempts have been made, both in this Country and in Germany to in- troduce the language of Chemiftry into Pharmacy ; but thefe attempts, however ufeful, were but feeble and incomplete. The honor of being the firft to compofea Pharmacopoeia in the pure and unmixed language of Scir ence,belongs indifputably to the Royal College of Phyficians of Kdinburgh, in the beginning of the Nineteenth Century. It is extremely probable that to this innovation many objections may be made; but it is probable that they will rather apply to the neceflary imperfections of the firft attempt, than to the principle itfelf, the propriety of which can fcarcely be doi b . !. twhen we confider, that Materia Medica and Pharmacy are but an applica- ion of Natural Hiftory and Chemiftry to a particular purpofe. II the general principle be admitted, it naturally follows, that the names of a!! Subftances employed in Medicine, fhould be the fame with the names of the fame fubftances, according to the moft approved fyftems of Natural Hiftory and Chemiftry, and that the titles of Compound Bodies fhould ex- cprefs as accurately as poflible the nature of their compofition. Confiderable difficulties, however, occur, in attempting to form a no- menclature in ftriCt conformity with thefe principles. The moft apparent of thefe is, that the titles of the more compounded medicines would be- come too verbofe and inconvenient, if they were to exprefs every ingredi- ent, although of little importance. The College, fully aware of this diffi- culty, have therefore contented themfelves with indicating in the t:t!es the principal ingredient only, on which their powers and ufes feem to depend. viii PREFACE. For the fame reafon, they have prefcribed fome well known fimples in very frequent ufe, by their common names, fucli as Opium, Mofchus, Caftoreum, Crocus Anglicus, thinking it fufficient to have pointed out in the catalogue of the Materia Medica the animals and vegetables from which they are ob- tained. , In moft cafes it is proper to mention both the Generic and Specific names of fimples ; but where it is neceflary to point out even the variety employed, it will be in general more convenient to omit the fpecific name, and to re- tain thofe of the genus and variety, as Aloes Socotorina for Aloes perfolia- ta Socotorina, Crocus Anglicus for Crocus fativus Anglicus. Alfo when any fubftance is obtained indifcriminately from feveral fpecies of the fame genus, the fpecific name may be omitted with propriety. Thus, it is fuf- ficient to fay, Rejina pint, Oleum volatile pint, &c. Another difficulty arifes from the Reformers of Chemical Nomenclature not having pointed out the manner of exprefling certain, and thefe very common forms of combination, without employing a periphrafis totally in- compatible with the brevity of a name. Pharmaceutifts have therefore been obliged to ftipply this deficiency from their own ftore. The Edinburgh College have accordingly retained fome titles, fuch as Tintlure and Spirit, which, although not ftrictly chemical, have been long received in Pharmacy, and are fo well underftood and defined that they can lead to no error or ambiguity. The principles, therefore, upon which the Edinburgh College have ef- tabliflied the new Nomenclature which they have introduced into Materia Medica and Pharmacy, appear to be fo rational and fcientific, that it can fcarcely fail to be generally adopted. As fcience advances, its imperfec- tions will be remedied, and its deficiences fupplied ; for, be fides other ad- vantages, it facilitates remarkably the application of difcoveries and im- provements in Natural Hiftory and Chemiftry. to the purpofes of medi- cine. CONTENTS. PART I. Elements gf Pharmacy. 9bjec7 and divifion of Pharmacy, SECTION I. Epitome of Chemistry. Page. Attraction and Refulfion, - ib. Aggregation, - - - - 2 Affinity, ^ ib. Clafjification of Jimple fubftances, - - - 3 Caloric y - - 4 Light, - - - ,. 6 Eleclricity, - - -/ V •-Galvanifm, - - - .^ ■ "/, _ . « 8 9 Magnet if m, - - ^fi • -Salifiable bafest - - /- 7 ib. ib. Oxygen, - | - 14 Nitrogen, -* - 16 Hydrogen, - - - r7 Carbon, - - - iS Metals and metallic oxides, - 22 Acids nuithfimple bafes, - - - ^ . 28 Compound oxides, - y 33 Ternary oxides, (Vegetable fubftances) -. - / jj . 34 Quarternary oxides, (Animal fubftances J 39 Compound acids, - - 42 7£r«ary acids, - - -, 43 Quarternary acids, - 4« X CONTENTS. 5* SECTION II. # Pharmaceutical Operations. Colleclion and prefervation of fimples, - - ' . 47 Mechanical operations of Pharmacy, - 49 Weighing and meafuring, - _ _ -, ib. Mechanical divifion, by pulverization, trituration, levigation and granulation, - Mechanical feparaiion byfifting, elutriation, decantation, filtration, exprefjion and defpumation, - ' _ . . *2 Mechanical mixture by agitation, trituration and kneading, 54 Apparatus, - -. ycjfels, ----".". jt: Lutes, - _ ._ Heat and fuel, - _ _ 5„ Furnaces, - _ . - 60 Chemical operations, - _ _ - 61 changing the form of aggregation, _ _ ib. Fujton, ib. Liquefaclion, - . 62 Vitrification, - - - ib. Vaporization, , - - _ .63" Uftulation, - . ib. Charring,^ ----- 64 Evaporation, - - ib. Concentration, 65 lnfpiffation, - - - ib. Exjiccation, - jb. Condenfation, - - - ib. Diftillation, - 66 Chemical operations. Circulation, g- Retlification, -0 Sublimation, - _ . _ -r Congelation, ... . j^ Coagulation, - _ „ jb" effecling combination, - ■ . jbj Solution, , Extratlion, - Abforption, Csnfolidation, ... effecling decompofition, - jb, Diffolution, - - - ib" Precipitation, , jb" Cryftallization, . . -g Oxygenizement, - . . -g Difoxygenizement, .- . _ 8l fermentation, _ 8 APPENDIX. Tables ofjimple affinity, _ Cafes of mutual decompofition, _ •* C«/W of difpofing affinity, _ " • _ 95 Formula for comparing the fc ales of different thermometers nuith each other, ... ., ' - 10. 72 73 74 APPENDIX. XI Table of the thermometric degrees, at vjhich fome remarkable chem- ical phenomena occur, - - 97 Table of freezing mixtures, - 99 Table of galvanic circles, - - ~ lOQ Weights and meafures, - - - - Ior Table of fpecific gravities, -, - l04 Table of the fallibility of different fubftances in -water, '°6 Table of the folubility of different fubftances in Alcohol, - ib. Table of the vjeight ofgafes abforbed by ivater, . - - 109 Explanation of the plates, - - - Iia PART II. Materia Medica. General obfervations, -* Iai Natural Medical and Pharmaceutical Hiftory of the different Articles contained in the Pharmacopoeias of London, Dublin and Edin- burgh, arranged according to the momenclature of the Edinburgh College, J23 APPENDIX. No. I. Concife account of fome fubftances contained in fome of the beft foreign Pharmacopoeias, but not received into the lifts of any of the Britifh Colleges, - - - - 3:7 No. II. Lift of animals vjhich furnifih articles »J the Materia Medica, < arranged according to Cuviers fyftem, - - 349 No. III. Lift of the genera of medicinal plants, arranged according to Linnaus, - - - * 350 No. IV. Lift of officinal plants, arranged according to their natural orders, by Dr. Murray, - 354 No. V. Lift of officinal fubftances belonging to the mineral kingdom, 358 PART. III. Preparations and Compositions. Chap. I. Sulphur, - 350 II. Acids, ... - 361 III. Alkalies and alkaline falts, - - 375 IV. Earths and earthy falts, - 410 • V. Antimony, - - - - - 422 VI. Silver, - - - - 43 S VII. Copper, - - 441 VIII. Iron, - - 444 IX. £>uickfilver, - 453 X. Lead, - - - 475 XI. Tin, - 477 XII. Zinc, ... - 47g XIII. Alcohol, ether andetherealfpirits, - -- 483 XIV. Drying of flowers and herbs, - - 491 XV. Expreffed juices, - 493 XVI. Infpiffatedjuices, - - - 496 XVII. Fixed oils, - 499 XVIII. Oily preparations, ... $9l xii CONTENTS. CHAP. XIX. Diftilled waters, - 5°3 XX. Volatile oils, - 5*° XXI. Empyreumatic volatile oils, - - 5X5 XXII. Diftilledfpirits, - - - 5*8 XXIII. Infuftons, - - - -522 XXIV. Decoclions, - - - - 527 XXV. Mucilages, - - - - 534 XXVI. 5yrK^j, , - - - - 53^ XXVII. Medicated honeys, - - - 546 XXVIII. Emulfions and mixtures, - - 549 XXIX. Medicated vinegars, -' - - 553 XXX. TincJures, - - - 557 XXXI. TincJures made ivitb etherealfpirits, - 578 XXXII. Ammoniated or volatile tinclures, - 580 XXXIII. Medicated vjines, - - - 584 XXXIV. Ex trails and rejns, - - - 588 XXXV. Powders, - - 599 XXXVI. Conferves, - 607 XXXVII. Elecluaries.and confeilions, - - 610 XXXVIII. Troches, 615 XXXIX. Pills, - - - - 619 XL. Cataplafms, - - - 627 XLI. Liniments, ointments, cerates, andplafters, - 6zl TABLES fhewing the proportion of antimony, opium, ana] mercury con- tained in different compofitions, - 650 Index of names that have been changed in the laft editions of the Lon^ don and Edinburgh Pharmacopeias, - - 654 Englifh index, - 66"j Latin index, ~ - - - - *?4 EDINBURGH NEW DISPENSATORY* PART I. ELEMENTS OF PHARMACY. i. 1 HE objeft of Pharmacy is to provide thofe* fubftances which may be employed for the prevention or cure of difeafes. 2. To obtain this object completely, an acquaintance with the phyfical and chemical properties of bodies is neceffary. This may be termed the Science of Pharmacy. 3. As few fubftances are found in nature in a ftate fit for their exhibition in medicine, they previously undergo various prepara- tions. Thefe conftitute the Art of Pharmacy. 4. Pharmacy is fo intimately connected with chemiftry, that the former can neither be underftood as a fcience, nor practifed with advantage as an art, without a conftant reference to the principles of the latter. For this reafon, it will be proper to premife fuch a view of the general doctrines of chemiftry, and of the moft re- markable properties of chemical agents, as is neceffary for the purpofes of Pharmacy. SECT. I. EPITOME OF CHEMIS Matter is of different fpecies. 6. The phenoma of matter are regulated by attraction arrchre.- pulfion. 7. Attraction comprehends thofe forces which caufe bodies to approach towards each other. B O' & Elements of Pharmacy. [Part. 1. 8. It operates a. at fenfible diftances, as in the attraction of gravity, elec- tricity and fnagnetifm. b. at infenfible diftances : a a. between particles of the fame fpecies, conftituting the attraction of cohefion or aggregation ; b b. between particles of different fpecies, the attraction of compofition or affinity. ij. Repulfion tends to feparate bodies from each other. 10. It alfo operates either a. at fenfible diftances, as in the repulfion of electricity and magnetifm \ or, b. at infenfible diftances, as in the repulfion of the matter of heat or caloric. il. The phenomena refulting from the operation of the fecond clafs of attractions, (8. b.) and feeondFclass of repulfions, (io. b.) conftitute the proper objett of chemiftry. Aggregation". 12. Bodies exift under different forms of aggregation : a. Solid, in which the attraction of cohefion reufts relative motion among the particles, either a a. perfectly, as in hard bodies ; or b b. imperfectly, as in fbft, malleable, ductile and elaftic bodies. b. Fluid, in which it admits relative motion among the par- ticles, either with facility ; or difficulty, as in vifcid flu- ids. ■c. Gafeous, in which the particles repel each other. Affiniiy. 23. Affinity is regulated by the following laws: a. It does not a6t at fenfible diftances. If. It is exerted only between integrant particles of different fpecies. c. It is exerted by different bodies, with different degrees of force. d. Moft bodies combine only in certain proportions. e. It is the inverfe ratio of faturation. f. Ifs aclion is oppofed by the attra6tion of aggregation. g. It is often accompanied by a change of temperature. h. Subftances,- chemically combined, acquire new proper- ties ; i. And cannot be feparated by mechanical means. Sect. I.] Epitome of Chemistry. 3 14. Affinity is a. fimple, when two bodies unite, in cbnfequence of their mutual attraction alone, whether thefe bodies be them- felves fimple or compound, and even although, in the lat- ter cafe, it be attended with decomposition. b. compound, when there is more than one new combination, and when the new arrangement would not have taken place, in confequence of the(attraclions tending to produce either combination fingly. c. difpofing, when bodies, which apparantly have no tenden- cy to unite, combine, in confequence of the addition of another body, which has a ftrong affinity for the compound. When the fcience of chemiftry comes to be better under- ftood, all the cafes at prefent referred to this laft fpecies of affinity, will probably be found to belong to one of the pre- ceding fpecies : For, it is abfurd to fuppofe, that a body can poflefs affinities before it is formed. 15. The attra&ions which tend to preferve the original arrange- ment of bodies prefented to each other, are denominated Quief- cent attractions ; thofe which tend to deftroy the original, and to form a new arrangement, are termed Divellent attractions. 16. It is evident, that no new arrangement can take place, un- lefs the divellertt be more powerful than the quiefcent attractions. Clarification of Simple Substances. \tj. Simple fubftances: a. Without appretiable gravity, Caloric. Light. Eledtricity. Galvanifm. Magnetifm. b. Gravitating fubftances : a a. Capable of fupporting combuftion, Oxygen. b b. Capable of combining with oxygen, Nitrogen. Hydrogen. Carbon.* Sulphur. Phofphorus. Metals. i: c. Having no affinity for oxygen, Earths. Alkalies. In treating of thefe fubftances, we (hall begin with the firft clafs, on account of the very great influence of caloric on all chem- ical attions : But, of the fecond clafs, we (hall firft confider the laft order, becaufe they are tangible objefts, confiderably perma- 9 4 Elements of Pharmacy. [Part I. nent in their properties, and fimple in their action ; and becaufe we fhall.thus become gradually familiarized with chemical lan- guage, before we enter upon the con fideration of fubftances, whofc properties are fcarcely the obje£b of our fenfes, and which are highly alterable in their nature, and complicated in their action. 18. Compound bodies.may be divided into a. primary compounds, confiftingof fimple fubftances com- bined with each other. Thefe may be fubdivided into binary, ternary, quaternary, &c. according to the number of their conftituents. b. fecondary compounds,confiding of compound bodies com- bined with fimple bodies, or with each other. 19. As the chemical nature of bodies is determined1 by their action on each other, and as, in every cafe, we fhould endeavor to advance from what is known to what is not known, the fimple fubftances will firft be defcribed, and then fuch of the primary compounds which they form with fubftances already treated of, as are not more conveniently arranged in feparate claffes. Caloric. 20. Heat, in common language, is a term employed, to exprefs both a certain fenfation, and the caufe producing that fenfation. In philofophical language, it is. now confined to the fenfation, and the term Caloric has been fubftituted to exprefs the caufe. 21. Temperature is that ftate of any body, by which it excites the fenfation of heat or of cold, and produces the other effects which depend on the prefence of caloric. 22. The moft general effect of caloric is expanfion ; the only real exception to this law, being the contraction of water from the 30th to the 40th degree or Fahrenheit's thermometer. This ex- panfion either confifis, a. in a fimple ihcreafe of volume ; or b. it produces a change of form in the fubftance heated. 23 The former fpecies takes place gradually, and at all tem- peratures, as long as the bodies expanded undergo no other change. 24. Bodies differ very much in the degree of expanfion, which equal increments of temperature produce in them. Gafes are more expansible than fluids, fluids than foli:h'. The individuals of each form of aggregation alfo exhibit con fid trable differences, 25. The fecond fpecies occurs ludJcal), and always at certain degrees of temperature. 26. The degree at which any folid is rendered fluid by means of caloric, is denominated its point of fufion ; and that at which either a folid or a fluid is converted into vapor, is its boiling ,point, or point of evaporation. Evaporation is much retarded by Sect. I.3 Epitome of Chemistry. 5 m * increafe of preffure, and facilitated by its diminution, infomuch, that thofe fubftances which, under the ordinary preffure of the atmofphere, feerh to pafs at once from the ftate of folid to that of vapor, may, by the application of fufficient preffure, be made to affume the intermediate ftate of fluidity. 27. From analogy, all bodies are considered as folid, when to- tally deprived of caloric ;• but- they are termed folid, fluid, orga- feous (12.) according to the ftate in which they exift at the ordina- ry temperature of the atmofphere. They are alfo termed fufible, or infusible, volatile or fixed, condenfible, or permanently elaftic, according to the effects of caloric upon them. 28. Another very general effefcl of caloric, is increafe of tem- perature. This effefcl is conftant when bodies retain their form of aggregation, or undergo the firft or gradual fpecies of expan- fion, (22 a.) but while they undergo the fecond or fudden fpe- cies (22. b.) they remain at one determinate temperature, that nec- effary for their fufion or vaporization, until the change be com- pleted throughout the whole. During the time neceffary to effefcl; this, the influx of caloric continues as before, and as it does not increafe the temperature, is is faid to become latent or combined. 29. The caloric neceffary for thefe changes, is beft denomi- nated the caloric of fluidity, and the caloric of vaporization ; and its quantity, is determinate with regard to each fubftance. 30. The abfolute caloric, or total quantity of caloric contained in any body, is perfectly unknown ; but the quantity which in- creafes the temperature of any body a certain number of degrees, is termed its Specific caloric, when its weight is the objefcl of cotn- ^>arifon ; and its Capacity for caloric, when its volume is confider- ed. The fpecific, and therefore the abfolute, caloric of bodies, varies very much. 31. Incandefcence is the leaft general effefcl of caloric, as it is confined to thofe fubftances which are capable of fupporting the very high temperature neceffary for its production, without being converted into vapor or gas. 32. On the living body caloric produces the fenfation of heat, and its general afclion is ftimulant. Vegetation and animal life are intimately connected with temperature, each climate fupport- ing animals and vegetables peculiar to itfelf. 33. Caloric influences affinity, both on account of the operation of its own affinities, and of its facilitating the afclion of bodies, by counterafcting the affinity of aggregation, (12.) For the latter reafon, it alfo promotes folulion, and increafes the power of fol- vents. 34. The particles of caloric repel each other : It is therefore difpofed to fly off in every direfclion from a body in which it is accumulated, or .to pafs off by radiation. 3 6 Elements of Pharmacy. [Part I. 35. Radiated caloric is tranfmitted with the velocity of light \ and, iike it, it is reflefcled and refrafcled. 36. Caloric is attrafcled by all other bodies. It has therefore an irrefiftible tendency fo to diftribate itfelf as to produce an uni- verfal equilibrium of temperature, or to pafs from bodies in which it is accumulated, into bodies in which it is deficient, until the at- traction of each for caloric, and the repulsive force (34.) of the caloric contained in each become equal to each other. 37. Caloric, communicated in this way, is faid to be conducted ; and the condufcling power of different bodies feems to be inverfely as their affinity for caloric. Metals are the beft condufclors ; then, Hones, glafs, dried wood. Spongy bodies, in general, are bad conduaors. Fluids alfo condufcl caloric ; but as they admit of mteftine motion among their particles, they carry it more fre- quently than they condufcl it. 38. The general effea.s of the abftraaion of caloric, are dimi- nu ion of volume, condenfation, diminution of temperature, and fenfation of cold. It alfo influences affinity, and, in general, re- tards folution. The abftraaion of caloric never can be total ;'and the attempts to calculate the thermometrical point at which it would take place have hitherto been fruitlefs. 39. The means employed to increafe temperature are, the rays of the fun, colled by means of a concave mirror, or double con- vex lens, elearicity, fridion, percuffion, collifion, condenfation and combuftion. Caloric is abftrafcled by rarefaaion, evaporation* and liquefafclion. 40. Temperature is estimated relatively by our fenfations and abfolutely by means of various inftruments. The thermometer indicates temperature, by the expanfion which a certain bulk of fluid undergoes from the addition of caloric, and by the condenfa- tion produced by its abftraaion. Mercury, from the uniformity of its expanfion, forms the moft accurate thermometer; but for temperatures in which mercury would freeze, alcohol muft be employed. Air is fometimes ufed to fhew very fmall variations o temperature. The pyrometer of Wedgewood, which is em- ployed for meafuring very high temperatures, depends upon the permanent and uniform contraaion of pure clay at thefe temner atures. ' v Licht. 41. Light emanates in every direflion from vifible bodies. 42. It moves in jlraight lines, with a velocity equal to 200*000 miles in a fecond ' 43. Its gravity is not appretiable. 44. When a ray of light paffes very near a folid body, it is in- flected towards it. J Sect. I.3 Epitome of Chemistry. 7 45. When it paffes at a diftance fomewhat greater, it is de- flefcted from it. 46. When a ray of light falls upon a polifhed furface, it is refleaed from it, and the angle ofreflcaion is equal to the angle of incidence. 47. Bodies which do not allow light to pafs through them are termed Opaque. 48. Bodies which allow it to pafs freely through them are termed Tranfparent. 49. When a ray of light paffes obliquely from one medium in- to another of greater denfity, it is bent towards the perpendicu- lar ; but if the fecond medium be of lefs denfity, it is bent from the perpendicular. The light, in both cafes, is faid to be Re- fraaed. 50. The refraaing power of bodies is proportional to their den- lities, except with regard to inflammable bodies, of which the re- frafcling power is greater than in proportion to their densities. 51. By means of a triangular prifm, light is feparated by re- frafclion into feven rays ; red, orange, yellow, green, blue, indigo, and violet. 52. Thefe rays are permanent, and fuffer no further change by refleaion or refraaion. £3. They differ in flexibility and refrangibility ; the red pof- feffing thefe properties in a lefs degree than the orange, the orange than the yellow, and fo on in the order of their enumeration. ^4. They poflefs different powers of illumination. It is great- eft between the yellow and green, and gradually declines towards both ends of the fpearum. 55. The different colors of bodies depend on their tranfmit- ting or refleaing thofe rays only which conftitute their particular colors. 56. White confiils of the whole prifmatic rays united. 57. Black is the total abfence of light, or complete fuffocation ,©f all the rays. ^8. Light poffeffes the power of heating bodies. ^9. The heating power of the different rays is inverfely as their refrangibility. €0. Bodies are heated by light inverfely as their tranfparency, and direaiy, as the number of rays fuffocated by them. 61. Light poffeffes the chemical property of Separating oxygen from many of its combinations ; and on this property its falutary; effeas on vegetable and animal life depend, 62. The difoxygenizing power of the different rays is in pro- portion to their refrangibility. 63. Light is abforbed by many bodies, cjqd again emitted by them-in the dark. A 8 Elements of Pharmacy. [Part. I, 64. The fources of light are the fan's rays, combuftion, heat, and percuffion. Electricity. 65. The particles of the elearic fluid repel each other, with a force decreafing as the diftances increafe. 6':. They attraa the particles of other bodies, with a force de- creafing as the diftances increafe ; and this attrafchon is mutual. 6y. They are difperfed in the pores of other bodies, and move with various degrees of facility through different kinds of matter. a. Bodies, through which they move without any perceiva- ble obftruaion, are called Nonelefclrics. b. Bodies, through which they move with very great diffi- culty, are called Elefclrics. 68. The phenomena of elearicity arife a. from the aaual motion of the fluid from a body contain- ing more into another body containing lefs of it ; b. from its, attraaion or repulfion, independently of any transference of fluid. 69. By rubbing elearics on each other, the distribution of the elefcmc fluid in them is altered. On feparating them, the one contains more, and the other lefs, than the natural quantity ; or, the one becomes positively, and the other negatively, elefclrified. 70 Elearics may alfo be excited by rubbing them with non- elearics. 71. If a body B be brought into the neighborhood of an elec- trified body A, B becomes elearified by pofition. 72. If a body B be infulated, that is in contaa with elearics only, when brought into the neigborhood of an elefclrified body A, a fpark paffes between them, accompanied by noife. B be- comes permanently elearified, and the elearicity of A is dimin- ifhed. 73. When a body A has imparted elearicity to another body B, they repel each other, unlefs B fhall have afterwards imparted all its elefciricity to other bodies. 74. Bodies repel each other when both are positively or both negatively elefclrified. 75. Bodies attraa each other, when the one is positively and the other negatively elefctrified. 76. 1( either of the bodies be in the natural ftate, they will nei- ther attraa nor repel each other. 77. The fpark [72.) is accompanied by intenfe increafe of tem- poral ure (39.) and will kindle inflammable bodies. 78. It produces very remarkable chemical effeas, depending chiefly on fudden and momentary increafe of temperature, and on the light produced. 79. Ekriricuy a3s on the living fyftem as a flirnulus. Sect. I.3 Epitome of Chemistry, 9 Galvanism. 80. The phenomena of galvanifm feem to depend folely on the .agency of elearicity, excited during certain chemical afclions. 81. The galvanic fluid is excited by arranging at leaft three heterogeneous bodies ; for inftance, two metals and a fluid, in fuch a manner that the two metals be in direfct contaa with each other in one part, and have the fluid interpofed between them in an- other. 82. The pile of Volta, by which it is rendered moft manifeft, is conftruaed, by combining a feries of fimple galvanic arcs (81.) into one continuous circle, in one uniform order of arrangement. 83. The folids capable of exciting galvanifm, are the metals and charcoal; and the moft efficient fluids are certain faline folu- tions. 84. Theeffeas of the fimple galvanic circle (8i.) on the ani- mal body, are the produaion of a fenfation of light when applied to the eye ; of an acid tafte on the tongue ; and the excitement of the mufcles through the medium of the nerves. 85. The pile, when well conftruaed, besides thefe effefcTs, alfo givesa fhock and fpark refembling thofe of elearicity (72.) and proves, that the galvanic aaion is always accompanied by the decompofuion of the fluid, and a combination of one of its con- ftituents with one ot the metals. Magnetism. 86. If an oblong piece of iron be fufpended freely, it will af- fume a determinate pofition with regard to the axis ot the earth. 87. When the fame end always points in the fame direaion, it is faid to poflefs polarity, or to be a magnet. 88. The similar poles of two magnets repel each other ; and the diffimilar poles attraa each other with a force decreasing as the diftances increafe. 89. Any piece of iron, when in the neighborhood of a mag- net, is a magnet ; and its polarity is fo difpofed, that the magnet and iron mutually attraa each other. 90. Magnetifm does not feem to affea fenfibility or irritability, or to influence chemical aaion. Salifiable Bases. 91. The great bulk of this globe confi (Is of earths and ftones. Although thefe vary infinitely in their external charaaer and physical properties, they are found to confift of a very few fub- ftances, mixed together indifferent proportions, and modified Ly external agents. 10 Elements of Pharmacy. [Part I. 92. Thefe elementary fubftances are termed Earths. Their gen- eral charaaers are, total want of inflammability, infufibility, fix- ednefs, a fpecific gravity lefs than five, inalterability, whitenefs, drynefs, brittlenefs, fparing folubility in water, and, in general, infipidity and want of fmell, capability of forming chemical com- pounds with acids, alkalies, fulphur, phofphorus, and oils, and fufibility when mixed with each other, or with alkalies, intocol- orlefs glaffes, enamels, or porcelains. 93. Alkalies are a clafs ot bodies which are commonly defined to be incombuftible, foluble in water, cauftic, and capable of neu- tralizing the acids, of combining with alcohol, oils, earths, fulphur and phofphorus, and of changing vegetable blues and reds to green : But as many of thefe properties are poffeffed in a greater or lefs degree by fubftances ufually claffed with the earths, and as there is a continual gradation from the infipidity, infolubility, and in- fufibility of filica, to the caufticity, folubility, fufibility, and com- parative volatility of potafs, we fhall treat ot them in fucceffion under the name of Salifiable Bafes. 94. Silica, when obtained perfeaiy pure by art, is in the form of a very fine powder, hard, rough and gritty to the touch ; when applied to the tongue, giving a rough and dry fenfation, but with- out tafte or fmeH, having a fpecific gravity of 2.66 ; when com- pletely difaggregated, foluble in 1000 times its weight of water ; foluble in the fixed alkalies and fluoric acid ; fufible with the fix- ed alkalies and other earths ; and combining by fufion with the metallic oxides, and the phofphoric and boracic acids. It has a tendency to cryftallization, and its ultimate particles feem to be tranfparent. It in general imparts to the foffils of which it is a principal conftituent, tranfparency, luftre, a tendency to cryftal- lization, and a degree of hardnefs, enabling them to flrike fire with fteel. Rock cryftal, quartz, agate, flint, calcedony, jafper, fhorl, are examples ot filiceous ftones. 95. Zirconia is obtained in the form of a fine white powder, al- most foft to the touch ; without tafte or fmell ; having, in a ftate of aggregation, a fpecific gravity of 4. 3 ; infoluble in water; in- fufible by heat alone, but, when furrounded by charcoal, its par- ticles become agglutinated, and fo hard as to ftrike fire with fteel ; foluble in all the acids ; fufible with filex and alumina ; infoluble in the alkalies, but foluble in their carbonates. It is only found in the zircon or jargon ot Ceylon, and in different varieties of hyacinth. 96. Alumina is obtained in friable fragments, or in a very fine white powder ; foft and unauous to the touch ; adhering ftrong- ly to the tongue, abforbing its moifture, and producing a flight fivpiic effea upon it ; fpecific gravity, 2 ; infoluble in water, but very diffufible through it; abforbing a certain quantity of it rap- idly, and forming with it a very duaile adhefive pafte, which •Sect. I.3 Epitome of Chemistry. II contraas and hardens remarkably in the fire, but is perfeftly infu- sible. Its ultimate particles feem to be opaque. It combines with moft of the acids, and thefe compounds have a fweetifh ftyp- tic tafte ; it unites with charcoal, the alkalies, baryta, ftrontita, lime, and filica; it ismanufaaured into porcelain and glafs. Fof- fils, containing much alumina, have generally a laminated ftruc- ture; it exifts cryftallized in fapphire ; and it forms thebafisof all clays, boles, mica, trap, bafaltes, flate, and corundum. gj. Yttria (Gadolina) is obtained in the form of a fine white powder, without tafte or fmell ; infoluble in water ; it does not alter vegetable blues ; is infusible ; infoluble in the alkalies, but readily foluble in the carbonate of ammonia. With the acids it jforms falts, which have a fweet and fomewhat auftere tafte. It has been found only in the gadolinite. 98. Glucina \i obtained in white light rnaffes or powder, of a foft feel, infipid, but adhering ftrongly to the tongue ; apyrous and infoluble in water, but forming with it a pafte, (lightly duc- tile andadhefive; it is foluble in potafs, foda, and carbonate of am- monia ; it combines with moft of the acids, forming foluble falts, difficultly cryftallizable, of a fweet and fomewhat astringent tafte, and with fulphuretted hydrogen. It has hitherto been found, very fparingly, only in the beryl and emerald. 99. Magne/ia is obtained in light white friable maffes, or very fine powder ; to the touch it is very fine ; its tafte is not very fen- fible, but peculiar and pleafant; its fpecific gravity is 2. 33. It is infoluble in water, but forms with it a pafte without duaility. It is apyrous ; flightly alters vegetable blues to green ; forms fo- luble compounds with moft acids, and unites with fulphur. The foffils, in which it predominates, are generally foft, and have an unauous feel; the principal are talc, fteatites, afbeftos, &c. 100. Lime is obtained in the form of a grey ftone, or in frag- ments more or lefs pulverulent and white ; warm, acrid, and urinous to the tafte ; reddening the fkin when applied to it for any time ; fpecific gravity 2. 33. It is foluble in 450 times its weight of water, and has a ftrong attraaion for it. If a certain quantity of water be thrown upon frefh burnt lime, itisabforbed rapidly, with the extrication of confiderable heat, and fome phof- phorefcent light ; at the fame time the lime crumbles down into a very fine, white, dry powder, augmented much in bulk, but lefs cauftic than before. Lime, thus flacked, does notrenew thefe phe- nomena, on a further addition of water, but may bediffufedordif- folved in it. It is apyrous ; it changes vegetable blues to green ; it combines withall the acids, fulphur, fulphuretted hydrogen, and phofphorus; it is very abundant in the mineral kingdom, and forms the bafes of animal bones andfhells. The calcareous fpaiv, marble, limestone, chalk, and marl confift chiefly of lime. 12 Elements of Chemistry. [Part I. 101. Slrontia is obtained in final], whitifh grey, and often porous maffes ; its tafleis warm, acrid and urinous; it isflightly cauftic, aaing feebly on animal matters. Taken into the stom- ach, it is not poifonous ; its fpecific gravity is nearly 4 ; it is foluble in 200 times its weight of water at 500, but in little more than fix times its weight of boiling water, which, on cooling, depofites flat rhomboidal cryftals , it is flaked more rapidly than lime, and it is inf ufible ; it changes vegetable blues to green ; it combines with all the acids, fulphur, fulphuretted hydrogen, and phofphorus, alumina, and filex. It is the bafis of fome ot the heavy fpars. 102. Baryta is obtained in fmall, grey, porous maffes, of toler- able folidity ; its tafte is acrid, urinous, and pungent; applied to the fkin, it proves cauftic, and it is deleterious when fwallowed ; its fpecific gravity is 4 ; it is foluble in twenty times its weight ot cold water, and in twice its weight of boiling water; depofiting, on cooling, tranfparent, white, prifmatic cryftals , when flaked, it boils up with violence ; becomes very hot ; increafes in bulk; and is changed into a fpongy, white mafs. It changes vegetable blues to green ; it is fufible; it combines with all the acids, ful- phur, fulphuretted hydrogen, and phofphorous. It is the bafis of fome of the heavy fpars. 103. Soda is got in the form of folid plates, .of a greyifh white color, urinous tafte, and burning caufticity ; aaing with con- siderable violence on animal matter. When a certain quantity of water is thrown upon it, itabforbs and folidifies it, with the dif- engagement of caloric, and alixivial fmell; a larger quantity dif- folves it ; it abforbs from the atmofphere moifture and carbonic acid, becoming lefs cauftic. In the fire it melts like an oily fub. fiance ; boils and is converted into vapor ; hut is incombufti- ble ; it is cryftallizable into tranfparent prifmatic cryftals. It changes vegetable blues to green ; unites with all the acids, oils, fulphur, fulphuretted hydrogen, phofphorus, many metallic ox- ides, and thcearths. It forms the bafis of rock fait and fea wa- ter ; is obtained from the afhes of marine plants, and exifts in fome mineral. 104. Potafs is a folid, white fubftance ; extremely acrid to the tafte; unctuous tothefeel, but highly cauftic ; destroying the fkin, and diffolving all foft animal fubftances. It is deliquefcent and foluble in hall its weight of water at 50° Fahrenheit; it is fufi- ble, and may be vaporized, but is perteaiy incombuftible ; it is capable c\ crystallizing into very long quadrangular, compreffed prifms, terminated by lharp pyramids; it changes vegetable blues to green, and combines with all the acids, oils, fulphur, fulphur- etted hvdro/.'en, and the earths. Jt is obtained from the aflies of •; ;•£<■•.,.";le.s, and ex;i!s in fome minerals. Sect. I.3 Epitome of Chemistry. 13 105. Ammonia is always claffed with the alkalies, from the analogy of its tafte, caufticity, combinations with the acids, and effefcts upon vegetable blues ; but as it differs in many particulars, being extremely volatile, and a compound fubftance, readily de- compofed, and formed in many chemical operations, and its com- position well known, we have ventured to feparate it from the alkalies, and refer it to that place, which, in all probability, it will always retain, and to which the other alkalies will, perhaps be referred, when their compofition (hall be deteaed. Primary Compounds of the Salifiable Bases. A. With each other ; earthen ware ; glafs. B. With fulphur; alkaline and earthy fulphurets. Vide Sul- phur. C. With phofphorus; alkaline and earthly phofphurets. Vide Phofphorus. 106. The fubftances of this clafs exert a considerable aaionon each other. Potafs was long believed to be the- only folvent of filica , and it is now further proved, that the whole of this clafs are capable of combining, when prefented to each other in a ftate of folution ; and on this property, in part, the effea of mortars de- pends. Their afclion on each other, by means of heat, is ot much greater importance, as it includes the theories of the manufac- tures of porcelain and glafs. 107. Porcelain, and all kinds of earthen ware, confift of alumina and filica, mixed in different proportions into a plaftic mafs, fabri- cated into various fliapes, dried and expofed to the heat of a fur- nace, where they undergo a kind of femifufion. They are glaz- ed by being thinly covered with a more fufible compofition, and may be afterwards painted with enamels, which are ftill more fufible than the glazing. 108. Glafs is compofed by melting about equal parts of potafs or foda with filica. It is harder and more durable in proportion to the excefs of the filica. The tranfparency of glafs depends upon its being cooled quickly ; for if cooled very flowly, it affumes a radiated crystalline appearance, and becomes perfeaiy opaque. By melting filica with about three times its weight of foda or potafs, a giafs is obtained, which not only is foluble in water, but even attraas moifture from the atmofphere. This folution has long been known by the name of Liquor Tot Flints. The proper- ty which metallic oxides have of rendering glaffes more fufible, and of imparting to them certain colors, has given rife to the arts of imitating precious Hones, and of enamcih'^. 14 Elements of Pharmacy. [Part. I. Oxygen. iog. Oxygen is the principleonwhichmoftof thechemical qual- ities of atmofpheric air depend Its tendency to combination is fo very ftrong, that it has never been procured in a feparate ftate. Oxygen gas, or the combination of oxygen with caloric, is its moft fimple form. This is permanently elastic, compreffible, tranfpa- rent inodorous and infipid. Its fpecific gravity is 0.00135. It fupports inflammation ; is neceffary for refpiration and vegetation, and is decompofed in all thefe proceffes; it constitutes 0.22 of at- mofpheric air. Oxygen is alfo a principal conftituent in water, in all acids and metallic oxides, and in almoft all animal and veg- etable fubftances. It is feparated from many of its combination^ by light, (61.) OxYGENIZEMENT. up. As thecharaaeriftic diftinaion between the fimple fub- ftances already treated of, and thofe which remain to be examin- ed, confifts in the former poffeffing no affinity whatever for oxygen, and #in the latter having a more or lefs ftrong attrac- tion for it, it will be proper to explain in this place, the general phenomena which attend the combination of oxygen with oxy- genizable bafes. The term Combuftion has been by the French chemifts incorreaiy extended to all thefe combinations ; for. in common language, that word is applied to cafes in which oxygen is not an agent, and always fuppofes the produaion of heat and light, although in numberlefs inftances of oxygenizement thefe phenomena do not appear. 111. Oxygenizement is an example of chemical union, and is fubjefcled to all the laws of affinity, (13.) h requires the prefence and contaa of oxygen, and of another fubftance poffefling affinity for it. 112. Oxygenizable bafes attraa oxygen with very different degrees of toice. This attrafclion is much influenced by temper- ature. Thus charcoal, which at ordinary temperatures feems to poflefs no attrafclion for oxygen, unites with it rapidly, and al- moft infeparably, when heated to ignition. 113. Oxygen combines with moft oxygenizable fubftances in certain definite proportions, perhaps only in one, and the appar- ent variety of proportions may be owing to a fecond or third fimilar combination of the firft compound with another quantity of oxygen, or of the bafe and of the fecond compouud with a third quantity. 114. Theattraaion between oxygen and the oxygenizable bales, is in the mverfe ratio ot faturdtion; or, in other words, the affinity by which th,-y form their pi imary combinations, is ftrong- Sect. 1-3 Epitome of Chemistry. 15 er than that by which they form any fecondary combination, and fo on progreffively. 115. In many inftances, oxygenizement is fo ftrongly oppofed by the affinity of aggregation, that it does not take place unlefs affifted by a degree of heat fufficient to melt or vaporize the oxa- genizable bafe. 116. It is alfo often accompanied by the extrication of caloric and light in a very confpicuous degree. To thefe the term com- buftion fhould be confined ; and only fuch oxygenizable bafes as are capable of exhibiting thefe phenomena are combuftible. Thefe phenomena depend upon the new compound, having a weaker af- finity or lefs capacity than its constituents for light and caloric, which are therefore extricated. 117. If the combuftible body be vaporized, flame is produced, and the procefs is then denominated Inflammation. 118. By its union with oxygenizable fubftances, oxygen un- dergoes very various changes of its properties. In many inftan- ces, the compounds of oxygen are fluid or folid, opaque, colored, incapable of fupporting inflammation, and deleterious to animal or vegetable lite. The changes which the oxygenizable bafes undergo, are no lefs confpicuous. Their form, color, tafte, odor, denfity, permeability to light and elearicity, fpecific caloric, and finally, their affinities, are often totally altered. 119. When, in confequence of oxygenizement, any fubftance acquires a four tafte, and the properties of converting vegetable blues to red, and of faturating or deftroying the charafcleriftic properties of alkalies and earths, it is faid to be acidified, and fuch compounds are termed Acids. 120. When it does not acquire thefe properties, the compounds are termed Oxides. 121. Many oxides are capable of being converted into acids, by combination with an additional quantity of oxygen. 122. Oxygenizable fubftances, combined with each other, are capable of combining as fimple fubftances with oxygen ; and the oxides or acids which refult from fuch combinations, are termed Oxides or Acids with a double or triple bafe. 123. In general, the bafes which are leaft fimple, unite with oxygen in the greateft variety of proportions. Primary Compounds of Oxygen. A. Binary, a a. with nitrogen : 1. Atmofpheric air. 2. Nitrous oxide. 3. Nitric oxide. 4. Nitric acid. 16 Elements of Pharmacy. [Pail L b b. With hydrogen ; water. c c. With carbon : 1. Incombuftible coal, plumbago. 2. Charcoal, (carbonous oxide.) 3. Gafeous oxide of carbon, (carbonic oxide.) 4. Carbonic acid. d d. With fulphur : 1, Oxide of fulphur. 2. Sulphureous acid. 3. Sulphuric acid. ee. With phofphorous : 1. Oxide of phofphorus. 2. Phofphorous acid. 3. Phofphoricacid. B. Ternary, with Carbon and Hydrogen. a a. Oxides. Hydrocarbonates, alcohol, ether, oil, vege- table fubftances. b b. Acids. Vegetable acids. C. Quaternary, with Hydrogen, Carbon and Nitrogen. a a. Oxides. Animal fubftances. b b. Acids. Animal acids. 124. Nitrogen, or azotic, g#j conftitutes o. 78 of the atmofpherej But as it has few attraaions at ordinary temperatures, its princi- pal effea on the chemical properties of the atmofphere feems to be the dilution of the oxygen gas, which in its pure ftate would be more aaive than is confiftent with the economy of nature. It alfo is permanently elastic, compreffible, inodorous and infipid ; it greens very delicate vegetable blues ; its fpecific gravity is 0.0011,5 ; it is unable to fupport refpiration, vegetation, or com- bustion, and is not decompofed in thefe proceffes; it is acidifiable, and is a conftituent of the nitric and nitrous acids, nitrous and nitric oxides, of ammonia, and perhaps ot the other alkalies, and of moft animal fubftances ; it diffolves phofphorus and carbon in fmall quantities, and is not abforbed by water. Primary Compounds of Nitrogen, (Azote.) A. Binary, a a. with oxygen : 1. Atmofpheric air. 2. Nitrous oxide. 3. Nitric oxide. (Nitrous gas.) 4. Nitric acid. b b. With hydrogen. Ammonia. (Nitroguret of Hydro- gen.) c c. With fulphur. Sulphuretted nitrogen gas. d d. With phofphorus. Phofphuretted nitiogen gas. Sect. I.] Epitome of Chemistry. 17 B. Quaternary, with hydrogen, carbon and oxygen. a a. Oxides. Animal fnbftances. b b. Acids. Animal acids. 125. Atmofpheric air, confifts of 22 parts of oxygen gas, and of 78 of azotic gas by bulk, or 25 and 75 by weight ; it is tranfpa- rent, compreffible, and permanently elaftic; its fpecific gravity is 0.00123 ; it is inodorous and infipid, refpirable, and capable of fupporting inflammation ; its component parts feem to he chem- ically combined. The atmofphere, befides the air now defcribed, alfo contains other gafes, water in folution, &c. 126. Nitrous oxide gas is compofed of 37 of oxygen, and 63 of nitrogen. It does not change vegetable colors ; its fpecific grav- ity is 0.00197 ; it fuffers no diminution when mixed with oxy- gen gas. Water abforbs about half its weight of it, at a mean temperature. It does not combine direaiy with alkalies ; it fup- ports combuftion ; and its refpiration, when perfeaiy pure, or mixed with atmofpheric air, produces the higheft excitement the animal frame feems capable of undergoing. 127. Nitric oxide gas (nitrous gas) confifts, according to Davy, of 44 azote and 56 oxygen. It does not change vegetable col- ors. Its fpecific gravity is 0.00I343. When mixed with about twofifths of oxygen gas, they condenfe into red fumes, (nitrous acid) which are entirely abforbed by water. The quantity of oxygen gas that any air contains is fometimes eftimated by the diminution of volume fuftained after a firflicient quantity of ni- trous gas has been mixed with it. Water tbforbs 0.118 of its bulk of this gas. It is not inflammable ; and only in very few inftanc- es fupports combuftion. It is noxious to vegetation, and its ref- piration is fatal to animals. j 28. Nitrogen admits of higher degrees of oxigenizement,form- at ing nitrous and nitric acids. 129. Hydrogengas is often found colleaed in mines and cav- erns, and perhaps conftitutes the upper ftrata of the atmofphere. It is permanently elaftic and compreffible. Its fpecific gravity is 0.000094, being the lighteft body with which we are acquaint- ed. It is highly inflammable, and burns in contaa with oxygen gas or atmofpheric air, and detonates on the application of a burn- ing body when mixed with them. It extinguifhes flame, and is deleterious to animal life. It diffolves fulphur, phofphorus and carbon, forming with them peculiar fetid gafes. Primary Compounds of Hydrogen. A. Binary, a. With oxvgcn ; water. b. With nitrogen ; ammonia. C 18 Elements of Pharmacy. [Part L c. Vv ith fulphur ; fulphuretted hydrogen. d. With phofphorus ; phofphuretted hydrogen. B. Ternary, a. With carbon and oxygen : i. Oxides ; hydrocarbonates, vegetable fubftances. 2. Acids ; vegetable acids. C. Quaternary, With carbon, nitrogen, and oxygen : l. Animal oxides. 2.---------acids. 130. Hydrogen, combined with oxygen in the proportion of 14.42, to 85.^8, forms water. Water is tranfparent, colorlefs, inodorous, «uid infipid. At 320 it exifts in a folid form, and is cryftallized. At 2:2° it expands to 2000 times its buik, and is converted into o very elaftic vapor. It abforbs fmall quantities ot the fimple gafes, efpecially oxygen. It diffolves feveral of the faiifiable bafes, and in fome degree all falinc bodies, and is effen. tial to their chryftallization. It is compoftd and decompofed in many inftances, and its chemical agency is almoft univerfal. It is the only binary combination ot hydrogen with oxygen. 131. Ammonia (hydroguret of nitrogen) confifts of four parts of nitrogen, with one of hydrogen. It exifts in its pureft form combined with caloric as a gas, which is perfeaiy tranfparent and cc■• lorlcfs, elaftic and compreffible ; fpecific gravity 0.000732 ; has, a urinous and acrid odour, irritating thenoftrils and eyes, and ;;n acrid and cauftic tafte; does not diffolve animal fubftances ; is irrefpirJjIe ; extinguifhes flame ; colors vegetable blues green ; fend is decompofed by being tranfmitted through a red hot tube, and by the elearic fpark, into its conftituent gales ; and by oxygen and atmofpheric air at a red heat, and by ox\ muriatic acid, it is converted into water and nitrogen gas. It is abfoibed without change by porous bodies ; it diffolves fulphur and phofphorus ; and combines readily v\ ith water in all its dates. Water is fatu- ratei by one third of its weight of gafeous ammonia, and is there- by increafed in bulk, and acquires the fpecific gravity of 0.90,5. Ammonia combines with all the acids, forming neutral falts. It is formed during the putrefaaive fermentation ; and it is common!}' chffed with the alkalies. 132. Carbon, in a ftate of pcrfe& purity, is well known by the raice of diamond. It poffefies the higheft degree ot luilre, trans- parency, and hardnefs. It is cryftalized, and generally colorlefs. Its fnccilic gravity, is from 3.44 to 3.55. It is infoluble in water, and can neither be melted nor vsporized by caloric. It is not afcted upon by any chemical agent, except oxygen at very high temperatures. When expofed in oxygen gas to the rays of the fun, concentrated by a very powerful lens, its furface becomes Sect. I.] Epiidme of Chemistry. 19 fenfibly blackened ; it is ignited, and at laft confumed. The re- fult ot this combuftion is carbonic acid gas ; 100 parts of which confift of 17.88 of carbon, and 82.12 of oxygen. It combines with iron, forming fteel. It is a conftituent of almoft all animal and veg- etable fubftances; and an oxide of carbon is obtained from them by exposing them to heat in clofed veflels. Primary Compounds of Carbon. A. Binary, a a. With Oxygen : 1. Incombuftible coal ; plumbago ; 2. Charcoal (carbonows oxide) 3. Gafeoiis oxide of carbon (carbonic oxide gas 4. Carbonic acid. b b. With metals ; carburets. B. Ternary, a a. With oxygen and hydrogen : 1. Oxides. a. Hydrocarbonates, gafeous. b. Alcohol, c. Ether, d. Fixed oil and fats, e. Wax, \ . >oxi des. 1 f. Adipocire, g. Volatile oils, A. Refins, i. Camphor, k. Starch, /. Sugar, m. Jelly, n. Tannin. 2. Acids. a. Acetous. *b. Acetic. c. Oxalic. d. Tartareous^ e. Citric. /. Malic. g. Laaic. h. Gallic. i. Mucous. k. Benzoic. /. Succinic. m. Camphoric. n. Suberic. 2 y fluid or fufible with- j outdecompofition. } folid,and infufible without decom- pofition. 20 Elements of Pharmacy. [Part I. o. Laccic. p. Sebacic. C. Quaternary, With nitrogen, hydrogen, and carbon. l. Oxides. a. Gum. b. Gumrefin. c. Extrafcl. d. Lignin. e. Suber. f. Caoutchouc. g. Gelatin. h. Albumen. i. Fibrin. k. Urea. 2. Acids. a. Pruffic. b. Zoonic. c. Uric. J. Amnic. 133. Plumbago and incombuflible coal contain carbon in the firft: degree of oxygenizement. The moft remarkable known proper- ty of this oxide, is the very high temperature neceflary for its combuftion. 134. Common charcoal of wood (carbonous oxide) is carbon in the fecond degree of oxygenizement, confi fling of 63.86 of carbon, and 36.14 of oxygen. It is obtained in the form of folid maffes ot a black color. It has neither fmell nor tafte. It is brittle and never cryftallized. It abforbs light ftrongly, is perfeaiy refrac- tory in the fire, infoluble in water, and a bad conduaor ot caloric, but an excellent one of elearicity. At a red heat, it burns rapid- ly in oxygen gas,-28 of charcoal and 62 of oxygen forming 100 of carbonic acid gas. It alfo burns in atmofpheric air, but lefs viv- idly. 135. Gafeous oxide of carbon (carbonic oxide gas) is carbon in its third degree of oxygenizement. It is invifible and elaftic ; fpe- cific gravity 0.001167. It does not fupport combuftion orrefpir- ation. With oxygen gas it burns with a lambent blue flame, and is converted entirely into carbonic acid without producing any Hioifture. It has no affinity for lime. It confifts ot 25.99 carbon, and 74.11 oxygen ; or 40.41 charcoal, and 59.59 oxygen. 136. Sulphur is a cryftallizable folid ; of a yellow color ; little fenfible tafte; particular fmell ; fpecific gravity 1.9907 ; brit- tle ; elefctric ; fufible at 1850 ; Converted into vapor at 1700 ; burning with a pale blue flame at 3020 ; and with a bright white flame at 5700 ; and capable of combining, with different propor- • Sect. I.] Epitome of Chemistry. 21 tions of oxygen. It is found pure in the neighborhood of volca- noes, and exifts in many minerals, and in animal fubftances. Primary Compounds of Sulphur. a. With oxygen : 1. Oxide of fulphur. 2. Sulphureous acid. 3. Sulphuric acid. b. With nitrogen. Sulphuretted nitrogen gas. c. With hydrogen. Sulphuretted hydrogen. d. With phofphorus. Sulphuretted phofphorus. e. With falifiable bafes. Earthy and alkaline fulphurets. J. With metals. Metallic fulphurets. 137. Oxide of Sulphur is of a reddifh brown color, and an auftere tafte. It is formed on the furtace of melted fulphur. 138. Sulphuretted Nitrogen Gas is only known to have a fetid odour. 139. Sulphuretted Hydrogen Gas confifts of 71 fulphur, and 29 hydrogen ; fpecific gravity 0.000135. It has the odour of rotten eggs; is notrefpirable ; burns with oxygen gas without explod- ing, and fulphur is depofited ; is readily abforbed by water, which is the mode in which fulphur exifts in mineral waters ; reddens vegetable blues; and in its affinities, and the cryftallizability of its compounds, it refembles the acids. 140. Hydroguretted Sulphur is fulphuretted hydrogen combin- ed with an additional dofe of fulphur. It has the appearance of a yellow oil. 141. Sulphurets are folid opaque bodies, of confiderable fpe- cific gravity, decompofible by heat, water, and the acids. a. The alkaline and earthy fulphurets have a red or brown- ifh red color, and *by folution in water are immediately converted into hydroguretted fulphurets. b. The metallic fulphurets have neither tafte nor fmell, are often poffeffed ot metallic brilliancy, and areconduaors of elearicity. 142. Phofphorus is a femi tranfparent folid, flightly brilliant, and of a waxy confidence ; fpecific gravity 2.0382 ; tafte in fome degree acrid and difagreeable ; fmell alliaceous. It is brittle un- der 320 ; its fraaure is vitreous, brilliant, and fometimes lamel- hted ; above 320 it foftens a little, becomes ductile about 900, melts at 1050, becoming tranfparent like a white oil; at 1800 be- gins to be vaporized, and at 5340 boils. It is cryftallizable into prifmatic needles or long ofctohedrons. It exifts in many mine- rals, and is obtained from bones and other animal fubftances. 22 Elements of Pharmacy. [Part 1, Primary Compounds of Phosphorus. a. With oxygen : i Oxide of phofphorus. 2. Phofphorous acid. 3. Phofphoric acid. b. With nitrogen. Phofphuretted nitrogen gas. c. With hydrogen. Phofphuretted hydrogen gas. d. With fulphur. Phofphuret of fulphur. e. With metals. Metallic phofphurets. f. With falifiable bafes. Alkaline and earthy phofphurets. iAO. In its folid ftate, phofphorus is not aaed upon by pure oxygen gas, but when melted, burns in it with a dazzling fplen- dor, abforbing about half its weight of oxygen, and forming phof- phoric acid. In atmofpheric air, below 1200, it undergoes a flow combuftion, emitting light in the dark, but without the produc- tion of fenfible heat; abforbing a poition of oxygen, and forming-. phofphorous acidj above 1200 it burns rapidly, but lefs brilliant- ly than in oxygen gas, forming phofphoric acid. It is therefore always kept immerfed in boiled water ; but even there its furface is oxidized, becoming white and opaque. 144. Hydroguretted phofphorus poffeffes a peculiar odour, and the property of becoming luminous when mixed with oxygen gas. It may be combined witha much larger proportion of phofphorus, acquiring then a fetid alliaceous odour, a cunfiderable increafe of fpecific gravity, and the property of burning by the fimple con- tafcl ot oxygen, or of the atmofphere, with a very brilliant white flame. 145. Sulphuretted phofphorus, and phofphuretted fulphur, are of a yellowifh color, more fufible than either of the components, and exceedingly inflammable. 14^. Nitrogen gas diffolves phofphorus, forming a fetid gas, which inflames at 4 low temperature. 147. Phofphuret of lime is infoluble in water; but when thrown into it, decompofes 1:, and produces phofphuretted h\ droaen gas, whofe bubbles catch fire when they burft on the fui face of the water. Phofphuret of barytes is a brown mafs ; of a metallic ap- pearance ; very fufible ; luminous in the dark ; decompofed by expofure to air ; emitting an alliaceous fmell when moiftencd ; and decompofed by water, furnifhing phofprmretu-ci hydrogen gas. The phofphuret of ftrontites is very fimilar. Metals, and Metallic Oxides. ^ 148. Metals arecrydallizable ; their form depends on the reg- ular tetrahedron or cube ; their furface is fpccular ; thev are per- Sect. I.] Epito?nc of Chemistry. 23 feaiy opaque ; their color is various; their luftre peculiar and fhining, or fplendent ; their hardnefs various, but at lead consid- erable ; many of them are brittle, others poffefs malleability and dufctility in a furprifing degree, and fome are fciffile, flexiie, or elaftic ; their frafclure in general is hackly ; theirtexture compaa, fibrous or toliated; many of them are remarkably fonorous; their fpecific gravity is great ; they poffefs no fmell or tafte, unlefs when heated or rubbed ; they are the beft conduaors of caloric and elearicity ; are powerful agents in producing the galvanic phenomena, and a few of them are the only fubftances which ex- hibit the phenomena of magnetifm. By the aaion of caloric they are melted, but with different degrees of facility, and fome a£ them may be vaporized. Except iron and platinum, they melt fuddenly, without undergoing any intermediate ftate of foftnefs ; and when melted, their furface is convex and globular. They are infoluble in water, but fome of them decompofe it, and are oxid- ized by it. Primary Compounds of the Metals. a. With oxygen : i. Metallic oxides. 2. Acids of arfenic, tungften, molybdenum, chrome, and columbium. b. With hydrogen. Hydrogurets. c. With carbon. Carburets. d. With phofphorus. Phofphurets. e. With fulphur. Sulphurets. f. With each other. Alloys and amalgams. 149. They are oxidized with different degrees of facility, fome by mere expofure to air, and others feem almoft to refill the ac- tion of heat and air. Their oxidizability is always increafed by increafe of temperature. Their oxides are in the form of potv- der, laminae, or friable fragments ; fometimes cryftalline; of va- rious colors, determinate with regard to each metal; poffefs great- er abfolute weight; arerefraaory, or fufible into glafs; infipid, or acrid, and ftyptic ; in general infoluble in water ; and combine either with acids and alkalies, or only with acids. Some of thofe are difoxygenized by light alone, others by_ caloric, and others re- quire hydrogen, carbon, &c. 150. Hydrogen gas is capable of holding arfenic, zinc, and iron in folution. 151. Carbon unites only with iron. 152. The metallic phofphurets a(e fufible, brilliant, brittle, granulated, larr.ellated, fcarcely combuftible, and permanent. 153. The fulphurets are brittle; cryftallizable in large brilliant and metallic laminae, more easily fufible th m the retraaory met- 4 24 Elements of Pliarmacy. [Part. I. als, but lefs eafily than the very fufible metals; decompofable by heat, humidity, and the acids. 154. The mixtures of the metals with each other are termed alloys ; thofe in which mercury is contained are amalgams. They "acquire by mixture new properties, and are in general more tufi- ble than their components. The reguline metals are not foluble in the acids ; but when aaed upon by them, are firft oxidized, and then diffolved. The metallic oxides, by fufion, color glaffes and enamels. Oxidizable Metals. 1^^. Gold is of a brilliant, yellow color, infipid, inodorous ; fpecific gravity between 19.258and 19.300 ; foft and flexible; lit- tle elafticity or fonoroufnefs ; fo dufclile, that its furface may be extended more than 650,000 times ; of very great tenacity ; eafily hammerhardened ; a good conduaor of caloric, elearicity, and galvanifm; fusing at 320 of Wedgewood ; brittle when cooled too quickly ; cryftallizing in oaohedrons ; unalterable in the air ; con- verted by a long and violent heat, into a vitrified, violet oxide; oxidized and djfperfed by elearicity; foluble in alkaline fulphu- rets ; rendered brittle by phofphorus, arfenic, bifmuth, tin, and antimony ; lefs brittle by lead ; foluble in mercury ; hardened by zinc, copper, iron, fteel, and filver ; oxidizable, ot a purple col- or, and flightly loluble, in nitrous acid; very oxidizable, of a fawn or yellow color by the nitro or oxymuriatic acids. Its oxide is eafily reduced by light and heat ; colors glaffes purple or topaze yellow, and forms a fulminating compound with am- A lipoma. 156. Platinum. Of a grey, white color, almoft black when poliihed, Infipid, inodorous ; fpecific gravity 20.850 to 21.061 \ fofter only than iron, and lefs dufclile only than gold ; moft diffi- cult of fufion, aboye 1600 of Wedgewood ; a good condufclor of clefclricity and galvanifm ; unalterable by air and heat; convert- ed into a grey powder, its firft. degree of oxidization, by elearic- ity ; unites with phofphorus ; forms alloys with arfenic, bifmuth, antimony, mercury, zinc, tin, lead, call iron, copper, filver, and gold. It is oxidized and diffolved by the oxymuriatic acid, and more readily by the nitromuriatic. Oxide grev. 157. Stiver. Very l.iiliant, white, infipid, inodorous ; fpecific gravity 10.47410 u.091 ; hardnefs between iron and gold ; elaftic- ity between gold and copper; ftrong acute found ; considerable dufctility and tenacity ; hardening much under the hammer ; a good conductor of electricity, caloric, and galvanifm ; fufible at 28° Wedgewood ; cryftallizable by cooling ; unalterable in the air ; changed into a greemfh oxide by long and violent heat, burning with a greenifh flame, and inftantly bv the elearic fhoch. Its phofpiiuiit is granulated, brittle a..d Lifible ; its fuiphuret grey, Sect. I.] Epitome of Chemistry. 25 black, lamellaled, orftriated and fufible ; it unites but flightly with the acidifiable metals and iron ; i6 hardened by gold, bifmuth, an- timony, tin, lead and copper, and amalgamates with mercury. It is oxidized, and diffolved by the fulphuric, fulphurous, nitric, and oxymuriatic acids. Its oxide, is greenifh ; reducible by light and heat, hydrogen, and the other metals ; colors fome glaffes of an olive green, and is very foluble in ammonia. 158. Copper. Bright red ; difagreeabie tafte and fmell when rubbed or heated ; duaile ; ot great tenacity ; fonorous ; fufible at 270 Wedgewood ; granulated texture, and fubjea to blifters; a good condufctor of caloric, elearicity, and galvanifm ; becomes brown, and at laft green, in the air ; when heated, turns blue, yel- low, violet, deep brown ; when ignited and plunged into water, forms brown, brittle fcales of oxide. Its phofphuret is brilliant, brittle, hard, and fufible ; its fuiphuret brown, fufible, and very phofphoric ; its alloy with arfenic is white, with bifmuth reddifh, with antimony violet, mercury deep red, with zinc formsbrafs, and with tin is orange; it is oxidized and diffolved by the fulphuric, nitric, and muriatic acids ; its oxide is brown, brittle, and foluble in ammonia, producing a beautiful blue. 159. Iron is of a bluifh grey color ; texture either fine grain- ed, fibrous or denfe plates ; fapid and odorous ; fpecific gravi- ty 7.600 ; the hardeft, and moft elaftic and moft tenacious metal; very dufclile ; fusing at 1300 Wedgewood, fufion at firft clammy, afterwards very fluid ; igniting by ftrong percuffion, and inflaming by the collision of flint ; magnetic. It is oxidized flowly in the air, efpecially when moid ; when heated in contaa with air, it is changed to a black oxide, containing 201027 of oxygen ; fufible, hard, brittle, lamellated, ftill attraaed by the magnet; afterwards into a brown, red, fine pulverulent oxide, not attraaed by the magnet, containing 0.40 to 49 of oxygen. It burns with fplendor and deflagration in oxygen gas, and is converted into a fufed, black oxide; it decompofes water flowly, and when ignited, very rapidly. In fome inftances it is diffolved in hydrogen gas. Car- bon united to iron, converts it into fteel. 160, Sleel is of a grey color, brilliant and granular in its fraaure ; fpecific gravity 7.795 ; harder than any of the metals, and more elaftic, dufclile, malleable, and fufible at a lower tem- perature than pure iron. Its charafcteridic property is, that af- ter being heated, if fuddenly plunged into cold water, it becomes harder, more eladic, lefs pliable and brittle ; but by being again heated and cooled flowly, it acquires its former foftnefs, pliability and ductility. Steel contains only fome hundred parts of carbon, and is known chemically, by letting a drop of acid fall upon it, which produces a grey cr black fpot. 26 Elements of Pharmacy. [Part. I. 161. Plumbago confifts of about 0.1 of iron, combined with car-, bon in its firft degree of oxidizement. The phofphuret of iron is white, granulated, brittle, permanent in the air. Its fuiphuret is yellow, hard, brittle, and very fufible, oxidizing flowly in a hu- mid atmofphere. Iron forms alloys with arfenic, cobalt, manga- ( nefe, bifmuth, antimony, zinc and tin. Iron is oxidized and dif- folved by almoft all the acids ; oxides, black, brown, red. It gives glaffes a brown, fmoky, deep green, or black color. 162. Lead is of a grey, blue, livid color, ftreak grey, difagree- able tade and odour ; fpecific gravity 11.352 ; foft; very lami- nable ; hardens little under the hammer ; very flexible ; flightly te- nacoius; fufibleat594° Fahrenheit; volatile atared heat; tarnifhed in the air ; flightly oxidized by air and water ; by heat and air it forms a grey, then a yellow, and, laflly, a red oxide, which is vit- rifiable. its phofphuret and fuiphuret are brittle ; it forms al- loys with arfenic, bifmuth, antimony, mercury, zinc and tin ; it is oxidized by, and combines with, the fulphuric, nitric, mu- riatic, phofphoric, and other acids. Its oxides impart to glafs a uniform denfity, and ftrong retraaing power. 163. Tin is pure, brilliant, white, fapid, and odorous ; fpecif- ic gravity 7.291 to 7.500, foft, flexible, and emitting a crackling noife when bent ; fufing at 4100 Fahrenheit ; oxidizes flowly in- the air ; is converted, when fufed, into a grey oxide ; when red hot it burns vividly. Its fuiphuret and phofphuret are lamellated and brittle; it forms alloys with arfenic, bifmuth, antimony, mercu- ry and zinc ; it is oxidized by many acids, and combines with the muriatic, fluoric, boracic, and carbonic acids. Its oxide is grey or white, unites readily with fulphur, and renders glaffes opaque. 164.Zinc is bluifh white, lamellated, fapid, and odorous; fpecif- ic gravity 7.190; laminable, foft, clogging the file; fufible at 7000; vaporizabie;a powerful agent in the phenomena of galvanifm; oxid- ized by fufion ; at a red heat it catches fire, and emits white films of oxide, which contain about 0.33 oxygen ; it is foluble in hy- drogen ; it combines with phofphorus, fulphur, arfenic, antimony, and mercury ; it eafily decompofes water; it is oxidized and dif- folved by ahnoft all the acids. Oxide, white films. 16^. Mercury. Very bright white ; fpecific gravity 3.563 ; freezing «.t—39 ; boiling at 248* ; partly duaile and malleable ; oxidizable by trituration in the air, and in a farther degree by the afciion of the air and heat; does not decompofe water ; forms amalgams with mnny metals ; it is oxidized and diffolved by the fulphuric, nitric, and oxymuiiatic acids. Oxides, black, yellow, red. 166. Tellurium. Whit.-, lead grey, very bright ; harfh andhrit-" tie; lamellated ; crvflallizable ; fpecific'gravity 6.115 ; ve: y fu- fible and volatile , burns with a blue and greenifh flame, and a Sect. 1.] Epitome of Chemistry. 27 white fmoke, having the odour of radifh ; oxide very fufible into a ftraw colored radiated glafs ; foluble in fulphuric, nitric, and nitromuriatic acids ; unites with fulphur. Oxides, black, white. 167. Antimony. White, very brilliant, lamellated; fpecific grav- ity 6.702 ; moderately hard ; polverizable ;tufible at 8090; vol- atile when highly ignited ; fenfible tafte and fmell ; unalterable in cold air ; oxidizable by air and heat ; oxide fufible into a yel- low brown glafs ; decompofes water when ignited ; oxidized by the fulphuric, nitric, and muriatic acids ; combines with phofpho- rus and fulphur. Oxides, black, brown, orange, yellow, white; and colors glafs yellow or hyacinthine. 168. Bi/muth: White, flightly yellow, in large fpicular plates ; pulverizable ; fpecific gravity 9.822 ; moderately hard ; fenfible odour and tafte ; very fufible and volatile at a high temperature ; oxidizable by heat and air ; oxide verifiable into a greenifh yel- low glafs; oxidizable by boiling fulphuric, nitric, and muriatic acids ; unites with fulphur. Oxides grey, yellow, dirty green, and colors glafs of a greenifh yellow. 160. Manganefe. Small whitifh grey globules ; fpecific gravi- ty 6.850 ; very hard and very brittle ; very difficult of fufion ; very oxidizable by expofure to air ; decompofes water ftrengly ; is oxidized by the fulphuric,nitric,muriatic acids; combines with many metals. Oxides white, red, brown, and black ; color brown, violet, or red ; difcolor glafs colored by iron. 170. Nickel. Yellow or reddifh white, granulated; fpecific gravity nearly 9 ; very difficult ot fufion, and of oxidization in the air ; oxidizable by moft of the acids, which it colors of a brilliant green ; combines with phofphorus, fulphur, and the met- als. Oxide light clear green, coloring glafs brown, orange, red. 171. Cobalt. Reddifh grey, fine grained, pulverizable ; fpecific gravity between 7.700 and 7.800; very difficult of fufion; oxidiz- able before fufion ; unalterable by water ; attacked by all the acids ; combines with phofphorus and fulphur; its alloys are gran- ulated, rigid, and brittle. Oxide deep blue or black, and colors glaffes ot a fine blue. 172. Uranium. An incoherent mafs offmall agglutinated glob- ules, of a deep grey and pale brown ; fpecific gravity 6 440 ; i-ery hard ; very difficult of fufion, even by long continued heat; is attacked by feveral ot the acids ; combines with phofphorus. Oxide foluble in the alkalies, and very foluble in their carbo- nates. Oxide yellow, coloring glafs of a greenifh yellow, em- erald green, or various brown. 173. Titanium. Agglutinated, hard, friable maffes, cryftalliz- ed, internally of a brilliant red; infusible; unalterable by wa- ter ; oxidizable by boiling fulphuric, nitric, and muriatic acids. Oxides, blue, deep red, white. 23 Elements of Pharmacy. [Parti. Acidifiable Metals'. 174. Chromum. Agglutinated maffes of a whitifh grey color ; very hard, very brittle, and very infufible ; appears to be difficult to oxidize and eafy to difoxidize ; does not appear to decompofe water ; not attacked by the fulphuric or muriatic acids ; changed into a green oxide, and afterwards into a red acid, by the nitric acid diftilled from it. Oxide of a beautiful emerald green ; acid a red or orange yellow powder. 175. Molybdenum. In black powder, or agglutinated, blackifh, friable maffes, having little metallic brilliance ; fpecific gravity 6 ; by a ftrong heat changes into a white brilliant oxide in nee- dles, and very acidifiable ; oxidizable by boiling fulphuric acid, and acidifiable by the nitric acid. It forms a fuiphuret ; and its alloys are granulated and triable ; acid white, pulverulent, ftyp- tic, fpecific gravity 8.400. 176. Tungjlen. Small flightly adherent globules of a flate- grey ; fpecific gravity 17.5 , very infufible ; oxidizable in the air by heat, and afterwards acidifiable. Oxide yellow, pulverulent, coloring glafs of a blue or brown color ; acid a white harfh pow- der ; fpecific gravity 3.600. 177. Arfenic. Grey plates ot a lively brightnefs ; friable; fpe- cific gravity between 8.310 and 5.763 ; vaporizable at540° ; emit- ting a fmell like garlic ; cryftallizable ; oxidizable in the cold air ; inflammable at a red heat, and fublimed in the form of the white oxide or acid ; farther oxidizable by the nitric and nitrous acids ; combines with phofphorus, fulphur, and many of the met- als ; foluble in hydrogen gas. Arfenious acid, white, cauftic, fublimable in white tetrahedrons, tranfparent, vitreous; fpecific gravity between 4 and 5. Arfenic acid, white, tranfparent, cauf- tic ; fpecific gravity 3.391 ; fufible ; not cryftallizable. 178. Columbiumhas hitherto been examined only in the ftate of eolumbic acid, which is a white powder infoluble in water. Acids with Simple Eases, and their Compounds. 179. The fimple fubftances, in their extreme ftates of oxygenize- ment, conftitute a ftrongly marked clafs of bodies termed Acids, which are diftinguifhed by the following properties : a. Their tafte is four ; b. They change vegetable blues to red ; c. They combine with water in almoft any proportion, without fuffering any charge in their properties, except what depend or; dilution. Sect. I.] Epitome of Chemistry. 29 d. They unite with alkalies, earths, metallic oxides ; forming compounds with them, poffeffed of new properties, and c/>m- monly known by the names of Neutral and Metallic Salts. 180. Befides fome of the metals, hydrogen is the only fimple fubftance which does not feem to be capable of acidification ; and, on the other hand, there are three acids, the muriatic, boracic,and fluoric, with whofe compofition we are ftill unacquainted. 181. Carbonic acid gas is tranfparent, colorlefs, without fmell, irrefpirable, and incapable of fupporting inflammation ; its fpe- cific gravity is 0,0018. Water abforbs an equal bulk of it at 410, acquiring a fpecific gravity of 1.0015, and an agreeable acidity and fparkling appearance, efpecially it heated to 88°. It is fepa- rated from water by freezing or boiling. It is alfo abforbed by alcohol, oil of turpentine, and olive oil. It contains 17.88 carbon, and 82.12 oxygen, or 28 charcoal and 72 oxygen. Its compounds are denominated Carbonates. 182. The carbonates always preferve their alkaline properties in fome flight degree. They are decompofed by all the acids, forming a brifk effervefcence, which is colorlefs. The carbonates of the metals very muchrefemble their oxides. 183. Nitrous acid is of a brown or red color, exceedingly vola- tile and emitting an intolerable and fuffocating odor. By the addi- tion of water, its color is fucceffively changed to blue, green, and yellow. In the ftate of vapor, it is abforbed by water, oil, and fulphuric acid. It confifts of fomewhat lefs than three parts of oxygen, and one of nitrogen, or rather of nitric acid and nitric ox- ide. It forms Nitrites. 184. The nitrites are charaaerized by their emitting the nitrous acid in orange fumes, on the addition of fulphuric acid. 185. Nitric acid confifts of nitrogen combined with oxygen. It is liquid, colorlefs, and twanfparent. It is very corrosive, and tinges the fkin of a yellow color. It has a ftrong affinity for wa- ter, and abforbs it from the atmofphere. When moil concentrat- ed, its fpecific gravity is 1-5543. It produces heat w» en mixed with water. It is decompofed by many fubftances. Light con- verts it in part into nitrous acid. When entjrely deprived of wa- ter, it fets fire to oils, to fulphuretted hydrogen gas, to iron filings, when perfeaiy dry ; and to zinc, bifmuth and tin, when poured on them in a ftate of fufion. it oxygenizes all the metals, except gold, platinum, and titanium. It confifts of four parts, by weight, of oxygen, and one of nitrogen. 186. The nitrates, by the aaion of fire, fumini impure oxygen gas, mixed with nitrogen, and are reduced to their bafes. By the aaion of concentrated fulphuric acid, they emit a white vapor, and they are capable of fupporting combuftion. 187. Sulphurous acid gas is colorlefs, incapable of maintaining combuftion, and deleterious when refpired. It has a ftrong fuflo- 30 Elements of Pharmacy. [Part. I. eating odour ; its fpecific gravity is 0.0046, or o 00251. Water at 540 rapidly abforbs one fourth of its weight of this gas, and when faturated, acquires the fpecific gravity of 1.040. It is again expelled from it by heat, but not by freezing. It is alfo abforbed by oils and ether. When water is prefent, it is converted by oxygen gas into fulphuric acid. It is decompofed by hydrogen, carbon, and fulphuretted hydrogen gas, when affifted by heat. It oxidizes iron, zinc, and manganefe. It confifts of 85 fulphur,and 15 oxygen. 188. Thefulphites, by the aaion of heat, furnifh fulphur, and become fulphates. They are alfo converted into fulphates, with eflervefcence, and exhalation of fulphurous vapors, by the ful- phuric, nitric, muriatic, and other acids, and gradually, by expof- ure to the atmofphere when dry, and very quickly when diffolv- ed. 189. Sulphuric acid is compofed of fulphurous acid and oxygen. It may be obtained in a cryftallized or glacial form, but generally exifts as a denfe liquid ; fpecific gravity 1.85 ; flightly vifcid ; tranfparent and colorlefs; without fmell ; of a ftrong acid tafte. In a fufficient degree of cold it freezes ; it boils at 5720. It has a ftrong attraaion for water, abforbing it rapidly from the atmof- phere, and producing confiderable heat when mixed with it. It is decompofed by moft inflammable fubftances. It does not oxid- ize gold, platinum, tungften, or titanium. It decompofes the alkaline and earthy fulphurets, and reduces all organic fubftances to charcoal. In medicine it is a powerful refrigerent and antifep- tic. It contains gd fulphur, and 44 oxygen. 190. The fulphates form fulphurets, when heated to rednefs with charcoah and furnifh copious precipitates with folutions of barytes. 191. Phofphorous acid is a white fluid of an oily appearance. It has a fetid odour, and difagreeable tafte ; and gives out a thick white fmoke arjd vivid flame when ftrongly heated. It is decom- pofed by ignited charcoal. The proportions of phofphorus and oxygen have not been afcertained. 192. Thephofphites are fufible, and when heated in clofe veffels furnifh a little phofphorus, and become phofphates. When heat- ed in the open air, they emit a phofphorefcent light, and often flafh- es of flame, accompanied by a ftrong fmell of garlic, and a thick white vapor, and are converted into phofphates. 193. Phofphoric acid is compofed of phofphorous acid and oxy- gen. It is cryftallizable, fufible and vitrefcent. Its fpecific grav- ity is 2.687. 1*/eadily attracts moifture from the atmofphere, and then its fpecific gravity becomes 1.417. Its mixture with water produces little increafe of temperature. It is decompofed at a high temperature by hydrogen and carbon, and by feveral ot the metals. It confifLs of 100 phofphorus and 154 oxygen. Sect. I.] Epitome of Chemistry. 31 194. The phofphates are cryftallizable, fixed, fufible, verifiable, and phofphorefccnt. They are not decompofed by charcoal. They are foluble in nitric acid without effervefcence, and precipitable from that folution by lime water. 195. Arfenious acidis ot a white color ; has a fharp acrid tafte, and an alliaceous fmell ; fpecific gravity 3.706 ; is foluble in eigh- ty parts of water at 6o°, and in fifteen at 2120. At 2830 it fub- iirncs ; if heated in clofe veffels is vitrified, and its fprcific grav- ity becomes 5.000. It confifts of 93 of arfenic, and 7 of oxy- gen, and is a mod virulent poifon. 196. The arfemtes are fcarcely known ; but their acid is driven off by heat, and is precipitated by all the acids. 197. Arfenic acid confifts of arfenious acid and oxygen. It is not cryftallizable ; has an acid cauftic tafte,and is not volatile, but very fixed and vitrifiablc. Its fpecific gravity is 3.391. It at- tracts moifture from the atmofphere, and is foluble in two thirds ot its weight of water. By a red heat it lofes part of its oxygen, and becomes arfeneous acid. It confids of 8 parts of arfenious acid, and 1 of oxygen, or of 91 arfenic, and 9 oxygen. 198. The arfeniales are decompofed by charcoal at a high tem- perature. 199. Tungflic acidis a white powder of a rough, metallic, and feebly acid tafte. Its fpecific gravity is 3.600. It is foluble in twenty parts of boiling water. Expofed to heat it becomes yel- low, brown, and laftly black ; emits no fmoke, and is not fufed ; but lofes its folubility in water. The fulphuric acid changes its color to blue, and the nitric and muriatic acids to a fine yellow. 200. The tungfates are little known. 201. Molybdic acid is a white powder of an acid but metallic tafte. Its fpecific gravity is 3.400. It is not altered in the air. It is melted, and is fixed in a covered crucible ; but when the cov- er is removed, it fublimes in a white fmoke, which condenfes in brilliant yellow fcales. It diffolves in 500 parts of hot water. By heat it forms a blue folution in fulphuric acid. It is alfo foluble in the muriatic, but not in the nitric acid. 202. The molybdates are fcarcely known. 203. Chromic acid is a red or yellow orange powder, of a partic- ular, rough, metallic tafte. It is foluble in water, and may be obtained in ruby colored cryftals. It is decompofable by he,:: and light, paffing to the ftate of green oxide. It is reduced by heat and charcoal. It oxygenizes the muriatic acid. 204. The chromates are of a yellow or orange color. 205. Columbic acid is a white powder, which reddens litmns paper, although it feems infoluble in water. It is foluble in boil- ing fulphuric and muriatic acids, but not in the nitric. It is pre- cipitated from its folutions by water, potafs, and fo..! mix with the juice. The oil itfelf may be obtained feparately, by expreffion with the fingers againft a plate of glafs. 52. For unauous feeds iron plates are ufed ; and it is cuftomary not only to heat the plates, but to warm the bruifed,feeds in a kettle over the fire, after they have been fprinkled with fome wa- ter, as by thefe means the produa is increafed, and the oil obtain- ed is more limpid. But as their difpdfition to rancidity is increaf- Sect. II.] Pharmaceutical Operations. 55 ed by it, if poffible this praaice fhould be laid afide, or confined to expofing the bruifed feeds, inclofed in a bag, to the fleam ot hot water. 53. Defpumation is generally praaifed on thick and clammy liquors, which contain much flimy and other impurities, not eafily feparable by filtration. The fcara arifes either by fimply heating the liquor, or by clarifying it, which is done by mixing with the liquor, when cold, the white of egg well beaten, with a little wa- ter, which on being heated coagulates, and entangling the impu- rities of the liquor, rifes with them to the furface, and may be eafily removed by a perforated ladle. Or the liquor may now be filtered with eafe. Spirituous liquors are clarified by means ot ifinglafs diffolved in water, or any albuminous fluid, fuch as milk, which coagulates by the a£lion of the alcohol without the affift- ance of heat. 54. Fluids can only be feparated from each other, when they have no tendency to combine, and when they differ in fpecific gravity. The feparation may be effbaed, by flamming off the lighter fluid with a fllver or glafs fpoon ; or by drawing it off by a fyringe or fyphon ; or by means of a glafs ieparatory, which is an inftrument having a projeaing tube, terminating in a very flender point, through which the heavier fluid alone is permitted to run ; or by means of the capillary attraaion of a fpongy wool- len thread ; for no fluid will enter a fubftance whofe pores are fill- ed by another, for which it has no attraaion ; and, laftly, upon the fame principle by means of a filter of unfized paper, previouf- ly foaked in one of the fluids, which in this way readily paffes through it while the other remains behind. gg. Mechanical mixture is performed by agitation, trituration, or kneading ; but thefe will be beft confidered in treating of the forms in which medicines are exhibited. Apparatus. g5. Before entering on the chemical operations, it will be ne- ceffary to make a few remarks on the inftruments employed in performing them. They may be divided into, a. The veffels in which the eflfeas are performed. b. The means of producing heat; or fuel; and, c. The means of applying and regulating the heat; or lamps and furnaces. Vessels. 57. The veffels, according to the purpofes for which they are intended, vary, a. In form, and, b. In materials. 4 4 56 Elements of Pharmacy. [Part I. 58. The different forms will be beft defcribed when treating of the particular operations. •• 59. No fubftance poffeffes properties which would render it proper to be employed as a material in every inftance. We are therefore obliged to felea thofe fubftances which poffefs the prop- erties more efpecially required in the particular operations for which they are intended. 60. The properties moft generally required, are a. The pow«r of refilling chemical agents. b. Tranfparency. c. Compaanefs. d. Strength. e. Fixity and infufibility. f. And the power of bearing fudden variations of tempera- ture without breaking. 61. The metals in general poflefs the four laft properties in eonfiderable perfeaion, but they are all opaque. Iron and cop- per are apt to be corroded by chemical agents, and the ufe of the latter is often attended by dangerous confequences. Thefe defeas are in fome meafure, but not entirely, remedied by tinning them. Tin and lead are too fufible. Platinum, gold and filver refift moft of the chemical agents, but their expenfe is an infurmounta- ble objeaion to their general ufe. 62. Good earthen ware refills the greateft intensity of heat, but is deficient in all the other properties. The bafis of all kinds of earthen ware is clay, which poffeffes the valuable quality of be- ing very plaftic when wrought with water, and of becoming ex- tremely hard when burnt with an intenfe heat. But it contra£ts fo much by heat, that it is extremely apt to crack and fplit on be- ing expofed to fudden changes of temperature ; it is therefore ne- ceffary to add fome fubdance which may counteraft this property. Siliceous fand, clay reduced to powder, and then burnt with a very intenfe heat, and plumbago, are occasionally ufed. Thefe additions, however, are attended with other inconveniences ; plum- bago efpecially is liable to combuftion, and fand diminifhcs the compatlnefs ; fo that when not glazed, they are porous, and when glazed they are aaed upon by chemical agents. The chemical veffels, manufaaured by Meffrs.Wedgewood, are the beft of this defcription, except porcelain, which is too expenfive. 63. Glafs poffeffes the three firft qualities in an eminent de» gree, and may be heated red hot without melting. Its greateft in- convenience is its difpofition to crack or break in pieces when fud- denly heated or cooled. As this is occafioned by its unequal ex- panfion or contraaion, it is beft remedied by forming the veffels very thin, and giving them in general a rounded form. Glafs yelfels fhould alfo be well annealed, that is, cooled very flowly, Sect. II.] Pharmaceutical Operations. 57 after being blown, by placing them immediately in an oven while they are yet in a foft ftate. When ill annealed, or cooled fudden- ly, glafs is apt to fly in pieces on the flighted change of tempera- ture, or touch of a fharp point. We may fometimes take advan- tage of this imperfeaion; for by means of a red hot wire, glafs vef- fels may be cut into any fliape. When there is not a crack already in the glafs, the point of the wire is applied near the edge, a crack is formed, which is afterwards eafily led in any direction we wifh. 64. Reaumeur's porcelain, on the contrary, is glafs, which by furrounding it with hot fand, is made to cool fo flowly, that it af- fumes a cryftalline texture, which deftroys its trafparensy, but imparts to it every other quality wifhed for in chemical veffels. The coarfer kinds of glafs are commonly ufed in making it ; but as there is no manufacture of this valuable fubftance, its employ- ment is ftill very limited. Lutes. 6g. Lutes alfo form a neceffary part of chemical apparatus. They are compositions of various fubftances intended a. To clofe the joinings of veffels. b. To coat glafs veffels. c. To line furnaces. 66. Lutes of the firft defcription are commonly employed te confine elaftic vapors. They fhould therefore poffefs the follow- ing properties : a. Compaanefs. b. The power of refilling acrid vapors. C. The power of refilling a certain intenfity of heat. d. Facility of removal after the operation. 67. Vifcid fubftances, as flour, ftarch, and gum, poffefs the firft and laft properties in a fufficient degree ; they are therefore em- ployed when the heat is moderate, and the vapor not corrosive. They are mixed with water, and fpread upon flips of paper or lin- en, which are wrapped round the joinings of the veffels, and, if neceffary, fecured with thread. Slips ot bladder macerated in wa- ter, and applied with the infide next the veffels, are employed ia the fame circumftances ; but from their great contraaionon dry- ing, they are apt to break weak veffels. A pafte formed of almond or linfeed meal, and water, or mucilage, forms a very clofe and plaftic lute, which is eafily removed. 68. Quicklime well incorporated with a fixth part of muriate of foda, or with white of egg diluted with water, applied on flips of finen, dries eafily,and becomes very hard. It is ufed for thediftil- 58 Elements of Pharmacy. [Part I. lation of the concentrated acids; but for this purpofe burnt gyp- fum and water is preferable. Both thefe lutes muft be ufed as foon as they are prepared, as they harden very quickly. 69. Chalk and oil, or glaziers putty, is a very compaa lute. As it becomes fo hard as not to be eafily removed, it is principally ufed for luting tubes into veffels for pneumatic purpofes. 70. A pafte of powdered clay and drying oil, or what is ftill better, amber varnifh, is very clofe, adhefive and plaftic, and is eafily removed ; but as it foftens with heat, it muft be fecured by flips of linen and thread, and will not adhere to the veffels unlefs they be perfeaiy dry. 71. Clay and fand, in the proportion of one to four, form an ex- cellent lute, capable of refilling very high temperatures, and the greateft number of corrofive fubftances. 72. Eight parts of yellow wax melted with one of oil of tur- pentine, with or without the addition of fome refinous fubftances, according to the degree of pliability and confiftence required, form a very clofeand compaa lute, through which the moft fubtile corrofive vauors will not efcape. But it is foftened and liquefied by heat, therefore cannot be ufed for purpofes where high tern* peratures are required. y^. The lute employed for the coating of glafs veffels, with the intention of making them ftronger and capable of rcfifting vio- lent heats, without foftening, confifts of four parts of fand and one of clay, made into a very thin mafs, and applied in fucceffive lay- ers, taking care that each coat be perfeaiy dry before another be laid on. 74. The lutes for lining furnaces will be defcribed when treat- ing of furnaces. 75. The junaure of veffels which are to be luted to each other, muft previoufly be accurately and firmly fitted, by introducing between them, when neceffary, fhort bits of wood or cork, or, if the difproportion be very great, by means of a cork fitted to the one veffel, having a circular hole bored through it, through which the neck of the other veffel or tube paffes. y6. After being thus fitted, the lute isrolled and worked between the fingers till it be foftened, and is then formed into fmall cylin- ders, which are fucceffively applied to the junaures, taking care that each piece be made to adhere firmly and perfectly clofe in every part before another is put on. Laftly, the whole is fecured by the flips of linen or bladder. jj. In many cafes to permit the efcape of elaftic vapors, a fmall hole is made through the lute with a pin, or the lute is per- forated by a fmall quill, fitted with a ftopper. Sect. II.] Pharmaceutical Operations. Heat and Fuel. 78. As caloric is an agent of the moll extensive utility in the chemical operations of pharmacy, it is neceffary that we fhould be acquainted with the means of employing it in the moft economic- al and efficient manner. 79. The rays of the fun are ufed in the drying of many vegetable fubftances, and the only attentions neceffary are to expofe as large a furface as poffibJe, and to turn them frequently, that every part may be dried alike. They are alfo fometimes ufed for promoting fpontaneous evaporations. 80. The combuftion of different fubftances is a much more powerful and certain fource of heat. Alcohol, oil, tallow, wood, turf, coal, charcoal and coke, are all occafionally employed. 81. Alcohol, oil, and melted tallow, are burnt in lamps of va- rious conftruaions. Thefe afford a very uniform, though not very high temperature. Alcohol has the great advantage of burning without fmoke. But oil burnt upon a cylindrical wick, fo contriv- ed that the air has free accefs both to the outfide and to the infide of the cylinder, as in Arg2^d's lamp, may be made to produce a confiderable temperature of great uniformity, and without the in- convenience of fmoke. 82. Wood, turf, coal, charcoal, and coke, are burnt in grates and furnaces. Wood has the advantage of kindling readily, but affords a very unfteady temperature, is inconvenient from us flame fmoke, and foot, and requires much attention. The heavy and denfe woods give the greateft heat, burn longeft, and leave a denle 83 Dry turf gives a permanent heat, and does not require fo much attention as wood ; but its fmoke is copious and penetrating, and the empyreumatic fmell which it imparts to every thing it comes in contaa with, adheres to them with great obftinacy. The heavy turf of marfhes is preferable to the light fuperhcial 84 Coal is the fuel moft commonly ufed in this country. Its heat is confiderable and fufficiently permanent, but it produces much flame and fmoke. 85 Charcoal, efpecially of the denfe woods, is a very conven- ient and excellent fuel. 'It burns without flame or fmoke, and gives a ftrong uniform, and permanent heat which may be eali.y regulated, efpecially when it is not in too large pieces, and is a little damp. _ „ ., . , 86. Coke, or charred coal, poffeffes fimilar properties to char- coal. It is lefs eafily kindled, but is capable of producing a .nguer temperature. 60 Elements of Pharmacy. [Part I, 87. When an open grate is ufed for chemical purpofes, it fliould be provided with cranes to fupport the veffels operated in, that they may not be overturned by the burning away of the fuel. Furnaces. 88. In all furnaces the principal objefts are, to produce a fuf- ficient degree of heat, with little confumption of fuel, and to be able to regulate the degree of heat. 89. An unneceffary expenditure of fuel is prevented by form. ing the fides of the furnace of very imperfea conduaors of calo- ric, and by conftruaing it fo that the fubjeft operated on may be expofed to the full aaion of the fire. 90. The degree of heat is regulated by the quantity of air which comes in contaa with the burning fuel. The quantity of air is in the compound ratio of the fize of the aperture through which it enters and its velocity. The velocity itfelf is increafed by mechanical means, as by bellows, or by increafing the height and width of the chimney. 9iyThe fize and form of furnaces, and the materials of which they are conftruaed, are various, according to the purpofes for which they are intended. 92. The effential parts of a furnace are, a. A body for the fuel to burn in. b. A grate for it to burn upon. c. An afh pit to admit air and receive the afhes. d. A chimney for carrying off the fmoke and vapors. 93. The afh pit fhould be perfeaiy clofe, and furniflied with a door and regifter plate, to regulate the quantity of air admit- ted. 94. The bars of the grate fhould be triangular, and placed with an angle pointed downwards, and not above half an inch diftatvt. The grate fhould be fixed on the outfide of the body. 95. The body may be cylindrical or elliptical, and it muft have apertures for introducing the fuel and the fubjeas of the opera- tion, and for conveying away the fmoke and vapors. 96. When the combuftion is fupported by the current of air naturally excited bv the burning of the fuel, it is called a wind- furnace ; when it is accelerated by increafing the velocity of the current by bellows, it forms a blaft furnace ; and when the body of the furnace is covered with a dome, which terminates in the chimney, it conftitutes a revcrberatory furnace. 97. Furnaces are either fixed, and built of fire brick, or porta- ble, ar»d fabricated of plate iron. When of iron, they muft, be lin- Sect. II.] Pharmaceutical Operations. 61 eel with fome badly conduaing and'refraaory fubftance, both to prevent the dissipation of heat, and to defend the iron againft the aaion of the fire. A mixture of fcales of iron and powdered titles Worked up with blood, hair, and clay, is much recdmmended ; and Profeffor Hagen fays, thas it is lefs apt to fplit and crack when ex- pofed at once to a violent heat, than when dried gradually, accord- ing to the common direaions. Dr. Black employed two different coatings. Next to the. iron he applied a compofition of three parts by weight of charcoal, and one of fine clay. Thefe are firft mixed in the ftate of fine powder, and then worked up with as much wa- ter as will permit the mafs to be formed into balls, which are ap- plied to the fides of the furnace, and beat very firm and compaa with the face of a broad hammer, to the thicknefs of about one inch and a half in general,but fo as to give an elliptical form to the cavity. Over this, another lute, compofed of fix or feven parts of fand, and one of clay, is to be applied in the fame manner, to the thicknefs of about half an inch. Thefe lutes muft be allowed to become perfeaiy dry before the furnace is heated, which fhould at firft be done gradually. 98. Heat may be applied to veffels employed in chemical ope- raions, a. Direflly, as in the open fire and reverberatory furnace. b. Or through the medium of fand ; the fand bath. c. Of water ; the water bath. d. Of fleam ; the vapor bath. e. Of air, as in the muffle. Chemical Operations. 99. In all chemical operations, combination takes place, and there are very few of them in which decompofition does not alfo occur. For the fake of method, we fhall confider them as princi- pally intended to produce, a. A change in the form of aggregation. b. Combination. c. Decompofition. 100. The form of aggregation may be altered by, a. Fufion. b. Vaporization. c. Condenfation. d. Congelation. e. Coagulation. 101. Fufion is the conversion of a folid into a liquid by the fole agency of caloric. Subftances differ very much in the degrees $6 Element* of Pharmacy. [Part I. 130. The former inftance is almoft fuppofititious ; for we are notable, by any dimunition of temperature, to reduce the per- manently elaftic fluids, to a fluid or folid ftate. 131. The latter inftance is always preceded by vaporization, and comprehends thofe operations in which the fubftances vapor- ized are condenfed in proper veffels. When the produa is a fluid, it is termed diftillation ; when folid, fublimation. 132. Diflillation is faid to be performed, a. Fid humidd, when fluids are the fubjeas of the opera- tion. b. Via ficcd, when folios are fubjeaed to the operation, and the fluid produa arifes from decompofition, and a new ar- rangement of the conftituent principles. 133. The objeas of diftillation are, a. To feparate more volatile fluids from lefs volatile fluids or folids. b. To promote the union of different fubftances. c. To generate new produas by the aaion of fire. 134. In all diftillations, the heat applied fljould not be greatel than what is neceffary for the formation of the vapor, and even to this degree it fhould be gradually raifed. The veffels alfo in which the diftillation is performed, fhould never be filled above - one half, and fometimes not above one fourth, left the fubftance contained in them fhould boil over. 135. As diftillation is a combination of evaporation and con- denfation, the apparatus confifts of two principal parts : a. The veffels in which the vapors are formed. b. The veffels in which they are condenfed. 136. The veffels employed for both purpofes are very various in their fhapesr according to the manner in which the operation is conduaed. The firft difference depends on the direaion of the Vapor after its formation. It either, a. Defcends ; diftillation per defcenfum. b. Afcends ; diftillation per afcenfum. c. Or paffes off by the fide ; diflillation per latus. 137. In the diftillation per defcenfum, a perforated plate of tin- ned iron, or other materials, is fixed within any convenient veffel, fo as to leave a fpace beneath it. On this the fubjea of the ope- ration is laid, and over it is placed another plate, accurately clofing the mouth of the veffel, and fufficiently ftrong to fupport the fuel. Thus the heat is applied from above, and the vapor is forced to defcend into the inferior cavity, where it is condenfed. In this way the oil of cloves is prepared, tar is manufaaured, and mercury and zinc feparated from their opes. Sect. II.] Pharmaceutical Operations. 67 138. In the diftillation per afcenfum, the vapor is allowed to arife to fome height, and'then is conveyed away to be condenfed. The veffel moft commonly employed for this purpofe is the com- mon copper ftill, which confifts of a body for containing the ma- terials, and a head into which the vapor afcends. From the middle of the head a tube rifes for a fhort way; and is then re- fleaed downwards, through which the fleam paffes to be condenf- ed. Another kind of head, rising to a great height before it is refleaed, is fometimes ufed for feparating fluids, which differ lit- tle in volatility, as it was fuppofed that the lefs volatile vapors Would be condenfed and fall back into the dill, while only the more volatile vapors would arife to the top, fo as to pafs to the refrigeratory. The fame objea may be more conveniently at- tained by managing the fire with caution and addrefs. The greater the furface expofed, and the lefs the height the vapors have to afcend, the more rapidly does the diftillation proceed ; and fo well are thefe principles underftood by the Scotch diftillers, that they do not lake more than three minutes to difcharge a ftill containing 50 gallons of wafh. 139. The condenfing apparatus ufed with the common ftill is very fimple. The tube in which the head terminates, is inferted into the upper end of a pipe, which is kept cool by paffing through a vaffel filled with water, called the refrigeratory. This pipe is commonly made of a ferpentine f orm; but as this renders it difficult to be cleaned, Dr. Black recommends a figmoid pipe. The refrig- eratory may be furnifhed with a ftopcock, that when the water it contains becomes too hot, and does not condenfe all the vapor produced, it may be changed for cold water. From the lower end of the pipe, the produa of the diftillation drops into the vef- fel deftined to receive it ; and we may obferve, that when any vapor iffues along with it, we fhould either diminifh the powerof the fire, or change the water in the refrigeratory. 140. Circulation was a procefs formerly in ufe. It confided in arranging the apparatus, fo that the vapors were no fooner con- denfed into a fluid form, than this fluid returned back into thedif- tilling veffels to be again vaporized ; and was effeaed by diflil- ling in a glafs veffel, with fo long a neck that the vapors were condenfed before they efcaped at the upper extremity, or by in- verting one matrafs within another. 141. When corrofive fubdances are diftilled in this way, the cucurbit and alembic are ufed ; but thefe fubftances are more con- veniently diftilled per latus. 142. The diftillation per latus is performed in a retort or pear- fliaped veffel, having the neck bent to one fide. The body of a good retort is well rounded, uniform in its appearance, and of an equal thicknefs, and the neck is fufficienily bent to allow the vapors, when condenfed, to run freely away, but not fo much as 2 1 G3 Elements of Pharmacy. [Part I. 1 to render the application of the receiver inconvenient, or to bring it too near the furnace. The paffage from the body into the neck mud be perfeaiy free and fufficiently wide, otherwise the vapors produced in the retort only circulate in its body, without paffinsr over into the receiver. For introducing liquors into the retort°without foiling its neck, which would injure the produft^ a bent funnel is neceffary. It mud be fufficiently long to intro- duce the liquor direaiy into the body of the retort ; and in with- drawing it, we muft carefully keep it applied to the upper part of the retort, that the drop hanging from it may not touch the in- fide of the neck. In fome cafes, where a mixture ot different fub- ftances is to be diftilled, it is convenient and neceffary to have the whole apparatus properly adjufted before the mixture ii made, and we muft therefore employ a tubulated retort, or a re- tort furnifhed with an aperture, accurately clofed with a ground ftopper. 143. Thetubulature fhould be placed on the upper convex part of the retort before it bends to form the neck, fo that a fluid poured through it may fall direaiy into the body without foiling the neck. 141. Retorts are made of various materials. Flintglafs is com- monly ufed when the heat is not fo great as to melt it. For dif- tillations which require exceffive degrees of heat, retorts of earthern ware, or coated (73. Sea. 2.) glafs retorts are employed. Quick- filver is diftilled in iron retorts. 145. The fimpleft condensing apparatus ufed with the retort, is the common glafs receiver ; which is a veffel of a conical or glob-* ular form, havingia neck fufficiently wide to 'admit of the neck of the retort being introduced within it. To prevent the lofs and diflipation of the vapors to be condenfed, the retort and receiver may be accurately ground to each other, or fecured by fome proper lute. To prevent the receiver from being heated by the caloric evolved during the condenfation of vapors in it, we muft employ fome means to keep it cool. It is either immerfed in cold water, or covered with fnow, or pounded ice, or a conftant evaporation is lupported from its furtace, by covering it with a cloth, which is kept moift by means of the defcent of water, from a veffel placed above it, though minute fyphojns or fpongy worft- fcd threads. But as, during the procefs of diftillation, permanent- ly elaftic fluids are oiten produced, which would*endanger the breaking of the veffels, thefe are permitted to efcape either through a tubulature, or hole in the fide of the receiver, or rather through a hole made in :he luting (fj. Sect. 2.) Receivers having a fpout iffuing from their fide, are ufed when we with to keep fep- arate the produ£is obtained at different periods of any diftilla- tion. For condenfing very volatile vapors, a ferieg of receivers, communicating with each other, termed Adopters, were formerly Sect. II.] Pharmaceutical Operations- 69 ufed ; but thefe are now entirely fuperfeded by Woulfe's appara. tus. 146. This apparatus confifts of a tubulated retort, adapted to a tubulated receiver. With the tubulature of the receiver, a three necked bottle is conneaed by means of a bent tube, the further extremity of which is immerfed, one or more irfehes, in fome fluid contained in the bottle. A feries of two or three similar bottles are conneaed with this firft bottle in the fame way. In the middle tubulature ot each bottle, a glafs tube is fixed, having its lower extremity immerfed about a quarter of an inch in the fluid. The height of the tube above the furface of the fluid muft be greater than the fum of the columns of fluid ftanding over the further extremities of the conneaing tubes, in all the bottles or veffels more remote from the retort. Tubes foadjuited are term- ed Tubes of Safety, for they prevent that reflux of fluid from the more remote into the nearer bottles, and into the receiver itfelf, which would otherwife inevitably happen, on any condenfation of vapor taking place in the retort, receiver, or nearer bottles.— Different contrivances for the fame purpofe have been defcribed by Meffrs. Welter and Burkitt; and a very ingenious mode of con- neaing the veffels without lute, has been invented by'Citizen Gi- rard, but they would not be eafily underftood without plates. T'he further tubulature of the laft bottle is commonly conneaed with a pneumatic apparatus, by means of a bent tube. When the whole is properly adjufted, air blown into the retort fhould pafs through the receiver, rife in bubbles-through the fluids contained in each of the bottles, and at laft efcape by the bent tube. In the re- ceiver, thofe produas of diftillation are collefted, which are con- denfable by cold alone. The firft bottle is commonly filled with water, and the others with alkaline folutions, or other active fluids; and as the permanently elaftic fluids produced, are fuccef- fively fubjeaed to the aaion of all of thefe, only thofe gafes will efcape by the bent tube which are not abforbable by any of them. Pneumatic Apparatus. 147. The great importance of the elaftic fluids in modern chem- iftry, has rendered an acquaintance with the means of colleaing and preferving.them indifpenfable. 148. When a gas is produced by any means, it may be received either, a. Into veffels abfolutely empty ; or, b. Into inverted veffels, filled with fome fluid, on which it ex- erts no aaion. 149. The firft mode (148. a.) of colleaing gafes, may be fulfilled by means of a bladder, moiftened fufficiently to make it perfeaiy . 3 70 Elements of Pharmacy. [Part I. pliable, and then compreffed fo as to prefs out every particle of air from its cavity. In this ftate it may be eafily filled with any gas. An oiled filk bag will anfwer the fame purpofe, and is more con- venient in fome refpeas, as it may be made of any fize or form. 150. Glafs or metallic veffels, fuch as balloons, may alfo be emptied for the purpofe ot receiving gafes, by fitting them with a ftopcock, and exhaufting the air from them by means of an air pump. 151. But the fecond mode of colleaing gafes is the moft conven- ient and common. It confifts in condutling the ftream of gas into an inverted glafs jar, or any other veffel filled with water or mercury. The gas afcends to the upper part of the veffel, and difplaces the fluid. In this way gas may be kept a very long time, provided a fmall quantity of the fluid be left in the veffels, which preveftts both the efcape of the gas, and the admiffion of atmofpheric air. 152. The veffels may be of various fhapes ; but the moft com- monly employed are cylindrical. They may either be open only at one extremity, or furnifhed at the other with a ftopcock. 153. The manner of filling thefe veffels with fluid, is to im- merfe them completely in it, with the open extremity direaed a little upwards, fo that the whole air may efcape from them, and then inverting them with their mouths downwards. 154. For filling them with convenience, a trough or ciftern is commonly ufed. This either fhould be hollowtd out of a folid block of wood or marble ; or, if it be conftruaed of wood fimply, it muft be lined with lead or tinned copper. Its fize may vary very much ; but it muft contain a fufficient depth of fluid to cover the largeft tranfverfe diameter of the veffels to be filled in it. Atone end or fide, there fhould be a fhelf for holding the veffels after they are filled. This fhelf fhould be placed about an inch and a half below the furface ot the fluid, and fhould be perforated with feveral holes, forming the apices of correfponding conical excava, tions on the lower fide, through which, as through inverted fun- nels, gafeous fluids may be more eafily introduced into the veffels placed over them. «q# *55- In general, the veffels ufed with a mercurical apparatus fhould be ftronger and fmaller than thofe for a water ciftern, and we muft have a variety of glafs and elaftic tubes for conveying the gafes from the veffels in which they are formed to the funnels under the fhelf. +56. Retlif cation is the repeated diftillation of any fluid When it renders the fluid ftronger, or abftra#s water from it, it'is term- ed Dephlegmation. When a fluid is diftilled off from any fub- ftance, it is called Abftraaion ; and if the produa be rediftilled from the fameTubftar.ce or a frefh quantity of the fame fubftance, ft is denominated Cohobation. V Sect. II.] Pharmaceutical Operations. 71 157. Sublimation differs from diftillation only in the form of the produa. When it is compaa, it is termed a Sublimate; when loofe and fpongy, it formerly had the improper appellation of Flowers. Sublimation is fometimes performed in a crucible, and the vapors are condenfed in a paper cone, or in another crucible inverted over it, fometimes in the lower part of a.,glafs flafk, cu- curbit or phial, and the condenfation is effeaed in the upper part or capital, and fometimes in a retort with a very fhort and wide neck, to which a conical receiver is fitted. The heat is moft com-^ monly applied through the medium of a fand bath; and the degree of heat, and the depth to which the veffel is inferted in it, are re- gulated by the nature of the fublimation. 158. Congelation is the reduaion of a fluid to a folid form, in confequence of the abftraaion ot caloric. The means employed for abltraaing the caloric, are the evaporation of volatile fluids, the folution of folids, and the contaa of cold bodies. 1«59< Coagulation is the converfion of a fluid into a folid of great- er or lefs confidence, merely in confequence of a new arrangement of its particles, as during the procefs there is no feparation of ca- loric or any other fubftance. The means of producing coagula- tion, are increafe ot temperature, and the addition of certain fub- ftances, as acids and runnets. Combination. 160. Chemical combination is the intimate union of the par- ticles of at leaft two heterogeneous bodies. It is the effea refulting from the exertion of the attraaion of affinity, and is therefore fub- jeaed to all the laws of affinity (13.) 161. To produce the chemical union of any bodies, it is necef- fary, 1. That they poffefs affinity for each other. 2. That their particles come into aa«al contaa. 3. That the ftrength of the affinity be greater than any coun- teraaing caufes which may be prefent. 162. The principal counteraaing caufes are, 1. The attraaion of aggregation. 2. Affinities for other fubftances. 163. The means to be employed for overcoming the aaion of •ther affinities (15.) will be treated of under Decompofition. 164. The attrafclion of aggregation is overcome by means of, 1. Mechanical divifion (28. Sect. 2.) 2. The aaion of caloric (22.) 4 72 Elements of Pharmacy. [Part I. 165. Combination is facilitated by increafing the points of aaual contaa, 1. By mechanical agitation. 2. By condenfation ; compreffion. 166. The proceffes employed for producing combination, may be confidered, '*' 1. With regard to the nature of the fubftances combined j and 2. To the nature of the compound produced. Gafes. 1. Combine with gafes; 2. And diffolve fluids or folids ; 3. Or are abforbed by them. Fluids, 1. Are diffolved in gafes ; 2. Or abforb them. 3. Combine with fluids, 4. And diffolve folids ; 5. Or are rendered? folid by them. {Solids, 1. Are diffolved in fluids and in gafes ; or 2. Abforb gafes, 3. And folidify fluids. 167. The combination of gafes with each other, in fome in- ftances, takes place when fimply'mixed together : Thus nitrous and oxygen gafes combine as foon as they come into contaft ; in other inftances, it is neceffary to elevate their temperature to a degree fufficient for their inflammation, either by means of the elearic fpark, or the contaa of an ignited bocsy, as'in the combi- nation of oxygen gas with hydrogen or nitrogen gas. 168. When gafes combine with each other, there is always a confiderable dimunitiop of bulk, and not unfrequently they are condenfed into a liquid or folid form. Hydrogen and oxygen * gafes form water; muriatic acid and ammonia gafes form folid muriate of ammonia. But when the combination is effeaed by ignition, a violent expanfion, which endangers the burfting" of the veffels, previoufly takes place, in confequence of the increafe of temperature. 169. Solution is the dimunition of aggregation in any folid or fluid fubftance, in confequence of its entering into chemical com- bination. The fubftance, whether folid or fluid, whofe aggrega- tion is leffened, is termed the Solvend; and the fubftance, by whofe agency the folution is effeaed, is.often called the Menftru- um or Solvent. *u . 170. Solution is faid to be performed via humidd, when the na- tural form of the folvent is fluid ; but when the agency of heat is Sect. II.] Pharmaceutical Operations. T3 neceffary to give the folvent its fluid form, the folution is faid to be performed via feed. 171. The diffolving power of each menftruum is limited, and is determinate with regard to each folvend. The folubility of bodies is alfo limited and determiaate with regard to each men- ftruunu 172. When any menftruum has diffolved the greateft poffibte quantity of any folvend, it is faid to be faturated with it. But, in fome cafes, although faturated with one fubftance, it is ftill ca- pable of diffolving others : Thus a faturated folution of muriate of foda will diffolve a certain quantity of nitrate of potafs, and af- ter that a portion of muriate of ammonia. 173. The diffolving power ot folvents, and consequently the folubility of folvends, are generally increafed by increafe of tem- perature ; and converfely this power is diminifhed by diminution of temperature ; fo that, from a faturated folution, a feparation of a portion of the folvend generally takes place on any reduaion of temperature. This property becomes extremely ufeful in ma- ny chemical operations, efpecially in cryftallization. 174. Particular terras have been applied to particular cafes of folution. 175. The folution of a fluid in the atmofphere is termed fpon- ianeous evaporation. It is promoted by expofing a large furface, by frequently renewing the'air in contaa with the furface, and by increafe of temperature. 176. Some folids have fo ftrong an affinity for water, that they attraa it from the atmofphere in fufficient quantity to diffolve them. Thefe are f$id to deliquefce. Others, on the contrary, re- tain their water of cryftallization with fo weak a force, that the atmofphere attraas it from them, fo that they crumble into pow- der. Thefe are faid to efflorefce. Both operations are promoted by expofing large furfaces, and by a current of air; but the lat- ter is facilitated by a warm dry air, and the former by a cold hu- mid atmofphere. 177. Solution is alfo employed to feparate fubftances, (for ex- ample, faline bodies) which are foluble in the menftruum, from others which are not. When our objea is to obtain the foluble fubftance in a ftate of purity, the operation is termed lixiviation, and as fmall a quantity of the menftruum as is'poflible is ufed. When, however, it is employed to free an infoluble fubftance from foluble impurities, it is termed edulcoration, which is beft performed by ufing a very large quantity of the menftruum. 178. Organic produas'jieing generally compofed of heteroge- neous fubftances, are only partially foluble in the different men- ftrua. To the folution of any of thefe fubftances, while the others •remain undiffolved, the term extra&ion is applied ; and when, by evaporation, the fubftance extraaed is reduced to a folid form, it 74 Elements of Pharmacy. [Part I. is termed an Extraa, which is hard or foft, watery or fpirituous, according to the degree of confiftency it acquires, and the nature of the menftruum employed. 179- Infuflon 1S employed1 to extraa the virtues of aromatic and volatile fubftances, which would be diffipated by decoaion, and deftroy ed by maceration, and to feperate fubftances of eafy folution from others which are lefs foluble. The procefs confifts in pouring upon the fubftance to be infufed, placed in a proper veffel, the menftruum, either hot or cold, according to the direc- tion, covering it up, agitating it frequently, and after a due time {training or decanting off the liquor, which is now termed the In- fufion. 180. Maceration differs from infufion, in being continued for a longer time, and can only be employed for fubftances which do not eafily ferment or fpoil. 181. Digeflion, on the other hand, differs from maceration only in the aaivity of the menftruum being promoted by a gentle de- gree of heat. It is commonly performed in a glafs matrafs, which fhould only be filled one third, and covered with a piece of wet bladder, pierced with one or more fmall holes, fo that the evapo- ration of the menftruum may be prevented as much as poffible, without rifk of burfting the veffel. The veffel may be heated, either by means of the fun's rays, of a common fire, or of the fand bath ; and when the laft is employed, the veffel fhould not be funk deeper in the fand than the portion that is filled. Some- times when the menftruum employed is valuable, a diftilling ap- paratus is ufed to prevent any wafte ot it. At other times, a blind capital is luted on the matrafs, or a fmaller matrafs is inverted within a larger one ; and as the vapor which arifes is condenfed in it, and runs back into the larger, the procefs in this form has got the name of Circulation. 182. Decotlion is performed by fubjeaing the fubftances oper- ated on to a degree of heat which is fufficient to convert themen- - ftruum into vapor, and can only be employed with advantage for extraaing principles which are not volatile, and from fubftances whofe texture is fo denfe and compaa as to refill the lefs aaive methods of folution. When the menftruum is valuable, that por- tion of it which is converted into vapor, is generally faved by condenfing it in a diftilling apparatus (136. Sect. 2.) 183. Solutions in alcohol are termed Tinaures, and in vinegar or wine, Medicated vinegars or,wines. The folution of metals in mercury is termed Amalgamation. The combinations of other metals with each other form Alloys. 184- Abforption is the condenfation of a gas into a fluid or fol- id form, in confequence of its combination with a fluid or folid. It is facilitated by increafe of furface and agitation ; and the powerof abforption in fluids is much increafed by compreffion. Sect. II.] Pharmaceutical Operations. 75 and diminution of temperature, although in every inftance it b« limited and determinate. Dr. Nooth invented an ingenious ap- paratus for combining gafes with fluids, and Meffrs. Schweppe, Paul and Cuthbertfon have very advantageoufly employed com- preffion. 185. Fluids often become folid by entering into combination with folids, and this change is always accompanied by confiderable increafe of temperature, as in the flaking of lime. Decomposition. 186. Decompofition is the feparation of bodies which were chem- ically combined. 187. It can only be affeaed by the agency of fubftances pof- fefling a ftronger affinity for one or more of the constituents of the compound, than thefe poffefs for each other (16.) 188. Decompofition has acquired various appellations accord- ing to the phenomena which accompany it. 189. Diffolution differs from folution in being accompanied by the decompofition, or a change in the nature ot the fubftance dif- folved. Thus we correaiy fay, a folution of lime in muriatic acid, and diffolution of chalk in muriatic acid. 190. Sometimes a gas is feparated during the a.aion of bodies on each other. When this efcapes with confiderable violence and agitation of the fluid, it is termed effervefcence. The gas is very frequently allowed to efcape into the atmofphere, but at other times is either colleaed in a pneumatic apparatus, or made to en- ter into fome new combination. The veffels in which an effer- vefcing mixture is made, fhould be high and fufficiently large, to prevent any lofs of the materials from their running over, and in fome cafes the mixture mud be made flowly and gradually. 191. Precipitation is the reverie ot folution. It comprehends all thofe proceffes in whieli a folid is obtained by the decompofi- tion of a folution. The fubflance feparated is termed a Precipi- tate, if it fink to the bottom of the fluid; or a Cream, if it fwim above it. Precipitation, like folution, is performed either via humidd, or via feed (170. Sect. 2.) 192. Precipitation is effeaed, 1. By leffening the quantity of the folvent \gy evaporation. 2. By diminifhing its powers, as by rcduaion of tempera- ture, or dilution. 3. Or by the addition of fome chemical agent, which from its more powerful affinities, a. Either combines with the folvent, and precipitates the , folvend ; b. Or forms itfelf an infoluble compound with fome con- ftituent of the folution. 193. The objeas of precipitation are, 76 Elements of Pharmacy. [Part I. l. The feparation of fubftances from folutions in which they are contained. 2. The purification of folutions from precipitable impurities. 3. The formation of new combinations. 194. The two firft means of precipitation have been already noticed (118, and 173, Sect. 2.) 195. In performing it in the laft manner, we may obferve#the following rules : _ '■> 1. The folution and precipitant muft poffefs the requifite de- gree of purity. 2. The folution fhould be perfeaiy faturated, to avoid un- neceffary expenditure of the folvent or precipitant. 3. The one is to be added flowly and gradually to the other. 4. After each addition, they are to be thoroughly mixed by agitation. $. We muft allow the mixture to fettle, after we think that enough of the precipitant has been added, and try a little of the clear folution, by adding to it fome of the precipi- tant ; if any precipitation takes place, we have not added enough of the precipitant. This is neceffary, not only to avoid lofs, but in many inftances, the precipitant, if added in excefs, rediffolves or combines with the precipitate. 196. After the precipitation is completed, the precipitate is to be feparated from the fupernatant fluid by fome ot the means al- ready noticed (44, 45 Sect. 2.) 197. When the precipitate is the chief objea of our procefs", and when it is not foluble in water, it is often advifable to dilute, to a confiderable degree, both the folution and precipitant, before performing the operation. When it is only difficultly foluble, we muft content ourfelves with wafhing the precipitate, after it is feparated by filtration. In fome cafes the feparation of the pre- cipitate is much affifted by a gentle heat. 198. Cryfallization is a fpecies of precipitation, in which the particles ot the folvend, on feparating from the folution, affume certain determinate forms. 199. The conditions neceffary for cryftallization are, 1. That the integrant particles have a tendency to arrange themfelves in a determinate manner, when aaed on by the attraaion of aggregation. s. That they be di{"aggregated, at leaft fo far as to poffefs fufficient mobility to affume their peculiar arrangement. 3. That the caufes difaggregating them be flowly and grad- ually removed. °' sqo. Notwithftanding the immenfe variety in the forms of cryf- Sect. II.] Pharmaceutical Operations. 77 tals, M. Hauy has rendered it probable, that there are only three forms of the integrant particles : l. The parallelopiped. 2. The triangular prifm. 3. The tetrahedron. 201. But as thefe particles may unite in different ways, either by their faces or edges, they will compofe cryftals of various forms. 202. The primitive forms have been reduced to fix : 1. The parallelopiped. 2. The regular tetrahedron. 3. The oaahedron with triangular faces. 4. The fix fided prifm. 5. The dodecahedron terminated by rhombs. 6. The dodecahedron with ifofceles triangular face*. 203. Almoft all fubftances, on cryftallizing, retain a portion of water combined with them, which is effential to their exiftence as cryftals, and is therefore denominated Water of cryftallization. Its quantity varies very much in different cryftallized fubftances. 204. The means by which the particles of bodies are difaggre- gated,fo as to admit of cryftallization, are folution (169, Sect. 2.) fufion (101, Sect.2.) vaporization (113,Sect. 2.) or mechanical di- vifion and fufpenfion in a fluid medium. 205. The means by which the difaggregating caufes are remov- ed, are evaporation, reduaion of temperature, and reft. 206. When bodies are merely fufpended in a ftate of extreme mechanicaldivifion, nothing but reft is neceffary for their cryftal- lization. 207. When they are difaggregated by fufion or vaporization, the regularity of their cryftals depends oh the flownefs with which their temperature is reduced ; for if cooled too quickly, their par- ticles have not time to arrange themfelves, and are converted at once into a confufed or unvaried folid mafs. Thus glafs, which when cooled quickly, is fo perfeaiy uniform in its appearance, when cooled flowly has a cryftalline texture. But in order to ob- tain cryftals by means of fufion, it is often neceffary, after the fubftance has begun to cryftallize, to remove the part which re- mains fluid, for otherwife it would fill up the interdices among the cryftals firft formed, and give the whole the appearance of one folid mafs. Thus, after a cruft has formed on the top of melt- ed fulphur, by pouring off the dill fluid part, we obtain regular cryftals. «.' 208. The means by which bodies, which have been difaggre- gated by folution, are made to cryftallize mo ft regularly, vary ac- cording to the habitudes cf the bodies with their folvents and ca- loric. 78 Elements of Pharmacy. [Part I. 209. Some faline fubftances are much more foluble in hot than in cold water. Therefore a boiling faturated folution of any of thefe will depofite, on cooling, the excefs of fait, which it is unable to diffolve when cold. Thefe falts commonly contain much wa- ter of cryftallization. 210. Other falts are fcarcely, if at all, more foluble in hot than in cold water; and, therefore, their folutions muft be evaporated either by heat or fpontaneoufly. Thefe falts commonly contain little water of cryftallization. 211. The beauty and fize of the cryftals depend upon the pu- rity of the folution, its quantity, and the mode of conduaing the evaporation, and cooling. 212. When the fait is not more foluble in hot than in cold wa- ter, by means of gentle evaporation a fucceffion of pellicles are formed on the top of the folution, which either are removed or permitted to fink to the bottom by their own weight ; and the evaporation is continued until the cryftallization be completed. 213. But when the fait is capable of cryftallizing on cooling, the evaporation is only continued until a drop of the folution, placed upon fome cold body, fhews a difpofition to cryftallize, or at farthest; only until the firft appearance of a pellicle. The folution is then covered up, and fet aside to cool, and the more flowly it cools, the more regular'are the cryftals. The mother water or folution, which remains after the cryftals are formed, may be re- peatedly treated in the fame way as long as it is capable of fur- nifhing any more fait. 214. When very large and beautiful cryftals are wanted, they may be obtained by laying well formed cryftals in a faturated fo- lution of the fame fait, and turning them every day. In this way ' their fize may be confiderably increafed, though not without limi- tation, for after a certain time they grow fmaller inftead of larger. 215. Crydallization is employed, 1. To obtain cryftallizable'fubftancesina ftate of purity. 2. To feparate them from each other, by taking advantage of their different folubility at different temperatures. Oxygenizement. 216. The combination of oxygen is the objea of many chem- ical and pharmaceutical proceffes. 217. With regard to the manner of combination, the oxygenize- ment may take place, either, a. Without theproduaion of heat and light, to exprefs which there is no other than the gerieric term oxygenizement.; or b. With the produaion of heat and light, combuftion. 1. In fubftances which remain fixed at the temperature neceffary for their combuftion, there is no other mori fpecific term. Sect. II.] Pharmaceutical Operations. 79 2. In fubftances which exift as gafes, or are previoufly re- duced to the ftate of vapor by the temperature neceffa- ry, it is termed inflammation ; and it it proceed with very great violence and rapidly, defagration. 218. Combuftion and inflammation have been already (116.) defcribed. *^ 2 19. Deflagration from its violence muft always be performed with caution. The common mode of conduaing this procefs, is to introduce the fubftances to be deflagrated together into any convenient veffel, commonly an iron pot, or crucible heated to rednefs. But to obviate any inconvenience, and to enfure the fuccefs of the procefs they are previoufly made perfeaiy dry, re- duced to powder, and thoroughly mixed together, and they are deflagrated gradually, for example by fpoonfuls ; but we muft take care always to examine the fpoon, left a fpark fhould adhere to it, which might fet fire to the whole mafs. During the procefs, the portion introduced fhould be frequently ftirred. 220. The oxygen neceffary for thefe proceffes,may be derived from the decompofition, a. Of oxygen gas or atmofpheric air. b. Of oxides, particularly water. - c. Of acids and their combinations, efpecially the oxygenized muriatic and nitric acids. 221. The different modes of oxygenizement are intended ei- ther, a. To produce heat and light (78, Sect. 2.) b. To obtain an oxygenized produa : 1. An oxide, when the procefs may be termed Oxidize- ment. 2. An acid, Acidification. t. To remove an oxygenizable fubftance. 222. Hydrogen, carbon and nitrogen, are never, unlefs for ex- periment, oxygenized as fimple fubftances. 223. Sulphur is converted into fulphuric acid by burning it in leaden chambers, or by deflagrating it with nitrate of potafs ; and phofphorus is acidified by inflammation in the atmofphere. 224. Of all the fimple oxygenizable fubftances, the metals are moft frequently combined with oxygen ; and as, in confequence of this combination, they Iofe their metallic appearance, they were formerly faid to be calcined or corroded. 225. Metals differ very much in the facility with which they are oxygenized by the contaa of oxygen gas. For fame, as iron and manganefe, the ordinary, temperature of the atmofphere is fufficient; others, as gold and platinum, fcarcely undergo any change in the moft violent heat. The operation is performed by 80 Elements of Pharmacy. [Part I, heating them to the requifite temperature, and expofing them to the aaion of the air ; and on the fufible metals it is promoted by ftirring them when melted. 226. Metals alfo differ in the mode of their aaion upon water. They are either capable of decomposing water, a. At ordinary temperatures, as iron, zinc, mangahefe, &c. b. At elevated temperatures, as antimony and tin ; or, c. When aaed upon at the fame time by an acid ©r an alkali, as copper, lead, bifmuth ; or, laftly, d. They'are incapable ot decompofing it, as gold, filver, mer- cury, platinum. 227. The oxygenizement of metals by water is promoted by the aaion of air. Iron for example, is more quickly rufted by being merely moiftened with water, than when totally immerfed in water. 228. But the acids are the moft powerful agents in oxygenizing metals. They do it in two ways, either 1. By enabling them todecompofe water (226, Sect. 2.) 2. By being decompofed themfelves. 229. Sulphuric acid is decompofed by very few metals, unlefs affifted by confiderable increafe of temperature ; but it powerfully promotes the decompofition of water. 230. Nitric acid is decompofed by many of them with very great violence, proceeding in fome inftances even to inflammation. It alfo oxygenizes them to the higheft degree of which they are fufceptible. It feldom produces the decomposition of water. 231. Muriatic acid is never decompofed, and only aas on thofe metals capable of decompofing water. 232. Oxygenized muriatic acid refembles the nitric, both in the violence of its aaion, and in the extent to which it carries the oxy- genizement of the metals. 233. The metals are fufceptible of different degrees ot oxygen* izement, fome ot them even of acidification, and, in general, they are more oxygenized according to the rapidity of the procefs. When proceeding too flowly, it may be accelerated by heat; when too violent, it muft be checked by diminution of temperature, as by plunging the veffel in which the operation is performing into cold water. 234. When the degree of oxygenizement is not very great, the oxide formed, generally enters into combination with the acid em- ployed, and formsa metallic fait ; but when carried to its higheft degree, the oxide is often infoluble. Sect. II.] Pharmaceutical Operations. 81 DlSOXYGENIZEMENT of METALLIC OxiDES and AdDS. 235' This procefs was formerly termed reduclion, from its re- ftoringthem to their metallic fplendor ; and is performed by cauf- ing fome body to aa upon them, which has a greater affinity for oxygen than they have. The different metals themfelves vary very much in the degree of this affinity, fo that they are reduced with very different degrees of facility. Gold, filver, platinum, and mercury, are reduced by merely expofing them to a fufficient degree of heat in clofe veffels. The oxygen at this temperature has a greater affinity for caloric than for the metals, and is there- fore driven off in the form of very pure oyxgen gas. 236. The other metallic oxides which refift the fimple aaion of heat, may be reduced by melting them in contaa with char- coal,or fubftances which may be charred (117.Sect.2.) fuch as oil, fat, refin, pitch, &c. Besides the charcoal, different faline mat- ters, fuch as alkalies, muriate of foda, fubborate of foda, &c. are alfo added to facilitate the fufion of the oxide. Soap is there- fore often ufed, and the black flux confifts of a mixture of potafs and charcoal, obtained by deflagrating two parts of tartar and one of nitrate of potafs. 237. The oxide to be reduced is mixed with a fufficient quan- tity of any of thefe fubftances, and placed in the bottom of a cru- cible, which is afterwards filled up with charcoal powder, to pre- vent entirely the accefs of the air, and expofed for a length of time to a fufficiently high temperature, when a button of the, me- tal will commonly be found in the bottom of the crucible. Upon the volatile metals, fuch as arfenic and zinc, this operation muft be performed in a diftilling or fubliming apparatus. Some metal- lic oxides, fuch as thofe of platinum, columbium, &c. cannot be reduced, from our being unable to produce a degree of heat fuffi- cient to melt them. 238. Metals may be alfo obtained from the metallic falts, by inferting in a folution of thefe a plate of another metal, poffefling a ftronger affinity for oxygen and for the acid. Thus copper is precipitated by iron, and arfenic by zinc. We muft only take care that the two metals have no remarkable affinity tor each other, as in that cafe an alloy is commouly produced. For example, when mercury is placed in a foJaiion of filver, a cryf- tallized amalgam of filver is obtained, formerly called the Arbor Dianae. 239. The compound oxides may be further oxygenized, by treating them with nitric acid. In this way various acids are formed, according to the nature of the oxide operated on, the quantity of the acid, and the mode of condua'mg the procefs. G 82 Elements of Pharmacy. [Part L.... 240. They alfo undergo changes by gradually combining with the oxygen of the atmofphere. In fome cafes, this combination is attended with remarkable phenomena, which have been chaffed under the term fermentation. 241. There are feveral fpecies of fermentation, which have been named from the produfcls they afford. 1. The faccharine, which produces fugar. 2. The vinous, which produces wine, beer, and fimilar fluids. 3. The panary, which produces bread. 4. The acetous, which produces vinegar. 5. The putrefattive, which produces ammonia. 242. The fame fubftances are fometimes capable of undergoing the firft, fecond, fourth, and fifth ; or third, fourth, and filth, fuc- ceffively, but never in a retrograde order. 243. The conditions neceffary for all of them, are, 1. The prefence of a fufficient quantity of fermentable mat- ter. 2. The prefence of a certain proportion of water. 3. The contaa of atmofpheric air ; and, 4. A certain temperature. 244. The faccharine fermentation.—The feeds of barley, when moiftened with a certain quantity of water, and expofed to the contaa of the atmofpheric air, at a temperature of not lefs than 500, fwell, and fhew marks of incipient vegetation, by pufhing forth the radicle. If at this period the fermentation be checked, by expofing them to a confiderable degree of heat, and drying them thoroughly, the infipid amylaceous matter, of which the feeds principally confifted, will be found to be changed in part in- to a fweet faccharine fubftance. The oxygen of the air, in con- taa with the feeds, is at the fame time converted into carbonic acid gas, by combining with part of the carbon of the feeds; and there is a confiderable increafe of temperature in the fermenting mafs, even to fuch a degree as fometimes to fet it on fire. Simi- lar phenomena occur in the maturation of fruits, in the cookery of fome roots and fruits, and during the heating of hay, when put up too wet. 245. The vinous fermentation.—Theconditions neceffary for the vinous fermentation, are the prefence of proper proportions of fugar, acid, extraa, and water, and a temperature of about 70°. When thefe circumftancesexift.an intedine motion commences in the fluid; it becomes thick and muddy ; its temperature increafes, and carbonic acid gas is evolved. After a time the fermentation , ceafes ; the feces rife to the top, or fubfide to the bottom ; the liquor becomes clear ; it has loft its faccharine tafte, and affumed a new one, and its fpecific gravity is diminlfhed. If the fermen- Sect. II.] Pharmaceutical Operaiions. 83 tation has been complete, the fugar is entirely decompofed, and the fermented liquor confifts of a large proportion of water, of alcohol, of malic acid, of extraa, of effential oil, and coloring matter. The fubftances moft commonly fubjeaed to this fermen- tation, are, Mutt, which is the expreffed juice of the grape, and which produces the beft wines; the juice ot the currant and goofe- berry, which, with the addition of fugar, form our homemade wines; the juices of the apple and pear, which give cyder and perry ; and an infufion of malt, which, when fermented withyeaft, forms beer. The brifknefs and fparkling of fome of thefe liquors, depends on their being put into clofe veffejs before the fermen- tation is completed, by which means a portion of carbonic acid gas is retained. 246. The acetous fermentation.—All vinous liquors are fufcep- tible of the acetous fermentation, provided they be expofed to t.he aaion of the atmofphere, in'a temperature not lefs than 700. An inteftine motion and hiding noife fenfibly take place in the fluid ; it becomes turbid, with filaments floating in it, and its tempera- ture increafes; it exhales a pungent acid fmell, without any dif- engagement of carbonic acid gas. Gradually thefe phenomena ceafe; the temperature decreafes ; the motion fubfides, and the liq- uor becomes clear, having depofited a fediment and red glairy matter, which adheres to the fides ot the veffel. During this pro- cefs, the alcohol and malic acid difappear entirely, oxygen is ab- forbed, and acetous acid formed. 247. Thepanary or coloring fermentation—is lefs underftood than thofe already defcribed. A pafte of wheat flour and water expof- ed at a temperature of 650, fwells, emits a fmall quantity of gas, and acquires new properties. The gluten difappears, and it acquires a four difagreeable tafte. If a juft proportion of this fermented pafte or leaven, or, what is ftill better, if fome barm be formed into a pafte with wheat flour and water, the fame fermen- tation is excited, without the difagreeable tafte being produced ; the gas evolved is prevented from efcaping by the vifcidity of the pafte, which therefore fwells, and, if baked, forms light, fpon- gy bread. 248. The putrcfa&ive fermentation.—Although vegetable fub- ftances, when they are deftroyed by fpontaneous decompofition, are faid to putrify, we fhall confider this fermentation as belong. ing exclufively to animal fubftances, or thofe which contain nitro- gen as an elementary principle. The effential conditions ot pu- trefaaion are humidity, and a temperature between 450 and 1 io°. The prefence of air, the diminution of preffure, and the addition of ferments, are not effential, but accelerate its progtefs. The fmell is at firft infipid and difagreeable, but afterwards infupport- ably fetid, although the fetor tor a time is fomewhat diminifhed by the mixture of an ammoniacal odour. Liquids become turbid 2 84 Elements of Pharmacy. [Part I. and flocculent. Soft fubftances melt down into a gelatinous mafs; in which there is a kind of gentle motion and fwelling up, from the flow and fcanty formation of elaftic fluids. Solids, befides the general foftening,exude a ferofity of various colors, and by degrees the whole mafs diffolves, the fwelling ceafes, the matter fettles, and its color deepens; at laft its odour becomes fomewhat aromat- ic, its elements are finally diffipated, and there remains only a kind of fat, vifcid, and ftill fetid mould. The produas of putre- faaion are carburetted, fulphuretted, and phofphuretted hydro- gen gafes, water, ammonia, and carbonic acid. Thefe are all diffipated in the form of gas or vapor. Zoonic acid, a fatty mat- ter, a foap compofed of this fat and ammonia, and often the nitric acid, fixed by a falifiable bafe, are alfo produced ; and the ulti- mate remains, befides falts, compofed of acid and earths, contain1 for a long time a portion of fat charry matter* [85] APPENDIX. TABLES OF SIMPLE AFFINITY. Oxygen. Carbon, Charcoal, ; Manganefe, 'Zinc, jiron, Tin, [Antimony, i Hydrogen, Phofphorus, Sulphur, Arfenic, Nitrogen, ' Nickel, Cobalt, Copper, Bifmuth, Caloric, Mercury, Silver, fnic, Oxide of arfe- Nitric oxide, Gold, Platinum, Carbonic oxide, j Muriatic acid, | White oxide of Manganefe, I White oxide of Lead. Oxygen.a. Titanium, Manganefe, Zinc, Iron, Tin, Uranium, Molybdenum, Tungften, Cobalt, Antimony, Nickel, Arfenic, Chromum, Bifmuth, Lead, Copper, Tellurium, Platinum, Mercury, Silver, Gold. Carbon. Oxygen, Iron, Hydrogen. TT ITROGEN. Oxygen, Sulphur, Phofphorus, Hydrogen. a. Vauquelin's Table of the affinity of the metals for oxygen, according to the difficulty with which their oxides are c^pcom- pofed by heat. 86 Elements ofPfiarmacy. [Part I, # Tables of Simple Affinity continued. ,--,----------- Sulphur. Potass, SoDA.and Hydrogen. Phosphorus, Ammonia. Oxygen, Potafs, Acids. Sulphuric, Sulphur, Soda, ----Nitric, Carbon, Iron, ----Muriatic, Phofphorus, Copper, ----Phofphoric, Nitrogen. Tin, ----Fluoric, Lead, ----Oxalic, Silver, ----Tartarous, Bifmuth, ----Arfenic, Antimony, ----Succinic, Mercury, ----Citric, Arfenic, ----Laaic,v Molybdenum. ----Benzoic, ----Sulphurous, ----Acetous, ----Mucous, ----Boracic, ----Nitrous, ----Carbonic, Pruffic, Oil, Water, 1 Sulphur. Appen.] Affinities. 87 Tables of Simple Affinity continued. Baryta. Strontia. Lime. Acids. Sulphuric, ----Oxalic, ----Succinic, ----Fluoric, Acids. Sulphuric, ----Phofphoric, ----Oxalic, ----Tartarous, ----Fluoric, ----Nitric, ---■— Muriatic, ----Succinic, —— Acetous, ---— Arfenic, ----Boracic, ----Carbonic, Water. » Acids. Oxalic, ----Sulphuric, ----Tartarous, ----Succinic, | ----Mucous, ----Mucous, ----Nitric, ----Muriatic, ----Suberic, ----Fluoric, ----Arfenic, ----Laaic, ----Citric, ----Malic, ----Benzoic, ----AcetoUs, ----Boracic, ----Sulphurous, j ----Nitrous, j ----Muriatic, ----Arfenic, ----Laaic, ----Acetous, ----Boracic, ----Sulphurous, ----Pruffic, Sulphur, Phofphorus, Water, Fixed oil. ...... Pruffir S Sulphur, Phofphorus, Water, Fixed oil. j 4 88 Elements of Pharmacy. [Part I. Tables of Simple Affinity continued. Magnesia. Alumina. Silica. Acids. Oxalic, Acids. Sulphuric, Fluoric a»id, ----Phofphoric, ----Nitric, Potafs. ----Sulphuric, —-— Muriatic, ----Fluoric, ----Oxalic, ! ----Arfenic, ----Arfenic, ----Mucous, ----Fluoric, ----Succinic, ----Tartarous, ----Nitric, ----Succinic, ----Muriatic, ----Mucous, ----Tartarous, ----Citric, -----Phofphoric, ■ ----Malic, ---Laaic, ---Laaic, -----Benzoic, ----Benzoic, ----Acetous, ----Acetous, ----Boracic, ----Boracic, ----Sulphurous, ——. Sulphurous, ----Nitrous, ----Nitrous, ■ Carbonic, ----Carbonic, ----Pruffic. ...... Pruffic [Sulphur. -~......' Appen.] Affinities, fffi Tables of Simple Affinity continued. Oxide of Platinum. ------Gold a. Ether. Gallic acid, Muriatic, •Nitric, Sulphuric, Arfenic, Fluoric, Tartarous, Phofphoric, Oxalic, Citric, Acetous, Succinic, Pruffic, Carbonic. Ammonia. Oxide of Silver. Gallic acid, Muriatic, Oxalic, Sulphuric, Mucous, Phofphoric, Sulphurous, Nitric, Arfenic, Fluoric, Tatarous, Citric, Laaic, Succinic, Acetous, Pruffic, Carbonic. Ammonia. Oxide or Mercury. v' Gallic acid, Muriatic, Oxalic, Succinic, Arfenic, Phofphoric, Sulphuric, Mucous, Tatarous, Citric, Malic, Sulphurous, Nitric, Fluoric, Acetous, Benzoic, Boracic, Pruffic, I Carbonic. a. Omitting the oxalic, citric, fuccinic, and carbonic, and add- ing fulphuretted hydrogen after ammonia. 90 Elements of Pharmacy. [Part I, Tables of Simple Affinity continued. Oxide of Lead. Oxide of Copper. Oxide of Arsenic. Gallic, Gallic, Gallic, Sulphuric, Oxalic, Muriatic, Mucous, Tartarous, Oxalic, Oxalic, Muriatic, Sulphuric, Arfenic, Sulphuric, Nitric, Tartarous, Mucous, Tartarous, Phofphoric, Nitric, Phofphoric, Muriatic, Arfenic, Fluoric, Sulphurous, Phofphoric, Succinic, Suberic, Succinic, Citric, Nitric, Fluoric, Acetous, Fluoric, Citric, Pruffic, Citric, Laaic, Malic, Succinic, Acetous, Boracic, Fixed alkaiies, " Laaic, Pruffic, Ammonia, Acetous, Benzoic, Boracic, PrHffic, Carbonic, Carbonic, Fixed oils, Fixed alkalies, Water. Ammonia, Fixed oils, Fixed oils. Ammonia. Appen.] Affinities. 91 Tables of Simple Affinity continued. Oxide of Iron. Oxide of Tin a. Oxide of Zinc. IOx.qf Antimony-I Ether. Gallic, Oxalic, Tartarous, Camphoric, Sulphuric, Mucous, Muriatic, Nitric, Phofphoric, Arfenic, Fluoric, Succinic, Citric, Laaic, Acetous, Boracic, Pruffic, Carbonic. i Gallic, m 1 Muriatic, Sulphuric, Oxalic, Tartarous, Arfenic, Phofphoric, Nitric, Succinic, Fluoric, Mucous, Citric, Laaic, Acetous, Boracic, Pruffic, Gallic, Oxalic, Sulphuric, Muriatic, Mucous, Nitric, Tatarous, Phofphoric, Citric, Succinic, Fluoric, Arfenic, Laaic, Acetous, Boracic, Pruffic, Carbonic, Gallic, j Muriatic, | Benzoic, j Oxallic, 1 Sulphuric, Nitric, Tartarous, Mucous, Phofphoric, Citric, Succinic, Fluoric, Arfenic, Laaic, Acetous, Boracic, Pruffic, Ammonia. Fixed alkalies, Ammonia. Fixed alkalies, lAmmonia. $ Cases of Mutual Decomposition. i. From Simple Affi Sulphate of Potafs, with Soda, — Ammonia, — Magnefia, — Superfulphate of Alumina, — Nitrate of Potafs, — Ammonia, —■ Muriate of Baryta, — Soda, — Lime, — Ammonia, — Phofphate of Soda, — Subborate of Soda, — Nitrate of Silver, — Acetite of Lead, — Sulphate of Mercury, — Soap of Potafs, — Soap of Soda, — nity (14. a.) Muriate of Baryta. Nitrate of Potafs. Muriate of Soda. Carbonate of Potafs. Muriate of Lime. Baryta. Phofphate of Soda. All the Sulphates and Ni- trates Carbonate of Potafs. Subborate of Soda. Carbonate of Potafs. Muriate of Ammonia. Carbonate of Potafs. Muriate of Soda. Citrate of Potafs. Muriate of Soda. Muriate of Soda. Sulphate of Lime. 2. From Com Sulphate of Baryta, Sulphate of Baryta, Potafs, Soda, Muriate of Baryta, Muriate of Lime, Phofphate of Soda, Acetite of Lead, Acetite of Lead, pound Affinity (14. b.) with Carbonate of Potafs. — Soda. — Muriate of Lime. ->— Muriate of Lime. — Phofphate of Soda. Subborate of Soda. — Carbonate of Potafs. — Soda. — Ammonia. — Carbonate of Ammonia. — Lime. — Sulphate of Zinc. — Nitrate ot Mercury. 96 Elements of PhaYmacy. [PartL Cases of Disposing Affinity (14. c.) The formation of water by the aaion of the fulphuric acid on tfie compound oxides. The oxidization of metals by water, in confequence of the pre- fence of an acid. Thermometers. Fahrenheit's therrhometer is univerfally ufed in this kingdom. In it -the range between the freezing and boiling points of water is divided into 180 degrees ; and as the greateft poffible degree of cold was fuppofed to be that produced by mixing fnow and muriate of foda, it was made the zero, and the freezing point be- came 320, and the boiling point 2120. The Centigrade thermometer of Revolutionized France, places the zero at the freezing point, and divides the range between it and the boiling point into 1000. This has long been ufed in Sweden under the title of Celfius's thermometer. Reaumeur's thermometer, which was formerly ufed in France, divides the fpace between the freezing and boiling of water into 8o°, and places the zero at the freezing point. Wedgewood's pyrometer is only intended to meafure very high temperatures. Its zero correfponds with 10770 of Fahrenheit's and each degree of Wedgewood is equal to 130 of Fahrenheit. Therefore 1800 F. =: 10o° C. — 8o° R. =150° D. = -LL W. Or to reduce centrigrade degrees to thofe of Fahrenheit, mul. tiply by 9 and divide by 5, and to the quotient add 00 that is, To reduce Reaumeur's to Fahrenheit's we have the following formula, f^-f 32 ™F. To reduce Wedgewood's degrees to thofe of Fahrenheit, \v- have 130 W. + 1077 ~ F- °r inverfely, 5 f — 3 2___r> 4,~"3*=R. 9 T.-._i o 7 j____-ry 130 Appen.] Thermometers. 97 Table of the Degrees of different Thermometers, omitting Frac- tions, at which fome remarkable Chemical Phenomena occur. Reau. Fahr. Cent. —35 -46 —43 —34 — 45 —42 —3a — 39 —39 —24 — 22 —30 —14 0 —18 0 32 0 5 43 6 6 45 7 22 82 28 27 92 33 28 95 35 29 98 36 3° 99 37 33 „io6 41 40 122 50 42 127 53 44 13° 54 50 *45 63 59 165 74 61 170 77 64 176 80 68 185 85 71 192 89 80 212 100 80 212 + 100 83 219 104 96 248 120 H2 283 140 120 3°3 150. I50 37° 188 164 400 205 168 410 210 190 460 238 226 54° 282 226 54°+ 282 228 546 285 2G Ether freezes. Ammonia exifts in a liquid form. Mercury freezes. Acetous acid freezes. Cold, produced by mixing equal parts of fnow and muriate of foda. Ice melts. Phofphorus burns flowly. Wax melts. The adipocere of mufcle melt*. Fat begins to melt. Spermaceti melts. Ether boils. Phofphorus melts. Refin of bile melts. Phofphorus burns vividly. Fat is perfeaiy fluid. Ammonia is feparated from water. Camphor fublimes. Albumen coagulates. Sulphur evaporates (Kirwan.) Alcohol boils. Sulphur melts (Kirwan.) Adipocere of biliary calculi melts. Water and volatile oils boil. Sulphur melts (Fourcroy.) Phofphorus evaparates. Nitric acid boils. White oxide of arfenic fublimes. Sulphur burns flowly, and camphor melu. Charcoal burns. Arfenic melts. Tin melts. Bifmuth melts. Lead melts (Newton ;) arfenic fublimes. Tellurium melts. Sulphuric acid boils (5400 Bergman.) 98 Elements of Pharmacy. [PartL Table of Degrees of Thermometers continued. Reau. i Fahr. Cent. VVedc. 232 554 290 a99 57o 239 2,50 594 312 252 600 3*5 z97 70O 37* 34» 800 427 * 345 809 432 5^4 1300+ 7°5 *-7 M5i 3297 1814 H 2024 45^7 253° 27 2082 47i7 2602 28 23*3 5237 2992 32 7975 17977 9969 130 913»,2°577 1*4*4 150 9602 21637 t2o01 158 1 970821877 12136 160 I1028623177 ^ 12858 170-f Phofphorus boils. Sulphur burns vividly. Lead melts (Morveau.) Mercury boils, linfeed oil boils. Sulphur fublimes (Davy.) Zinc melts. Hydrogen gas burns. Antimony melts. Azotic gas burns. Diamond burns (Sir G. Macken- zie.) Copper melts. Silver melts. Gold melts. „ Cobalt melts. Nickel melts. Iron melts. Manganefe melts. Platinum, tungften, molybdenum/ uranium, and titanium melt< / / Appen.] Freezing Mixtures. 99 Table of Freezing.Mixtures^ During the folution of many faline bodies, a very confidera- ble reduaion of temperature takes place. We fhall extraa from Mr. Walker's paper a few ot the moft convenient mixtures em- ployed for this parpofe. A mixture of~\ [reduces the tern-perature. Muriate of ammonia, Nitric of potafs, Water, 5 Parti 5 16 ■' ► from 5b0 to io°. Sulphate of foda, Muriatic acid, 8 5 > from 500 to o°. Snow, Muriate of foda, Snow, Muriate of foda, } l l 2 1 1 5 5 1 1 J > from 320 to o°. > from o° to—50. Snow, Muriate of foda, Muriate of ammonia, and Nitrate ot potafs, > from—50 to—180. Snow, Muriate of foda, Nitrate of ammonia, 12 5 5 ► frbm—i8°to—250. Snow, Diluted fulphuric acid, i l >• from 200 to—6o°. Snow, Muriate of lime, 2 3 1 ► from 320 to—50°. Snow, Muriate of lime, i 3 1 1 > from—40°to—730. Snow, Diluted fulphuric acid, 8 io » from—68° to—910. The falts ought to be recently cryftallized, and reduced to a Very fine powder, and the mixture fhould be made as quickly as poffible. To produce a very great degree of cold, the materials muft be previoufly cooled down by means of other mixtures. 2 100 Elements of Pharmacy. [ParfcL Table of fome Galvanic Circles, compofed of two Per- fea Conduaors, and one Imperfea Conduaor (Davy.) with gold, charcoal, filver, copper, tin, iron, mer cury. ----gold, charcoal, filver, copper, tin. ---- gold, filver, charcoal. ----gold, filver. gold, filver. gold. 1 3 B Solutions of nitric acid in water, of muriatic acid, ful phuric acid, &c. Water, holding in folution oxygen, at- mofpheric air. SJ >T) Solution of nitrate, -n of filver, and mer. cury. Nitric acid, acetous acid. Nitric acid. Table of fome Galvanic Circles, compofed of two Im-* perfea Conduaors, and one Perfea Conduaor. ° Charcoal, Co /-» a Copper, c Silver, rS 'Lead, cS|Tin- & :Iron, lii7' « Z,mc. P-* o cd 3 a retted alkaline ful-! 1: acid, oxygenizedmu- ^j phurets, capable ofjrj viatic acid, &c. ca- # aaing on the firftj ^ jpable of acling on all Ji three metals, but notjviJ 'tb.* metals. ^on the-la ft three. 6 Solutions of hydrogu-|_n iSolutio»« of nitrous Appen.] Weights and Measures, \0) Weights and Measures. ** To employ, as the fundamental unity of all meafures, a type taken from nature itfelf, a type as unchangeable as the globe on which we dwell—to propofe a metrical fyftem, of which all the parts are intimately conneaed together, and of which the mul- tiples and fubdivifions follow a natural progreffion, which is fim- ple, eafy to comprehend :—This is moft affuredly a beautiful, great, and fublime idea, worthy of the enlightened age in which we live." Such were the ideas which influenced the French National In- ftitute, when they chofe as the bafe of the whole metrical fyf- tem, the fourth part of the terreftrial meridian between the equa- tor and the north pole. They adopted the ten millionth part of this arc for the unity of meafure, which they denominated metre, and applied it equally to fuperficial and folid meafures, taking for the unity of the former the fquare of the decuple, and for that of the latter the cube of the tenth part of the metre. They chofe for the unity of weight, the quantity of diftilled water which the fame cube contains when reduced to a conftant ftate prefented by nature itfelf; and, laftly, they decided, that the multiples and fubmultiples of each kind of meafure, whether of weight, capac- ity, furtace, or length, fhould be always taken in the decimal pro- greffion, as being the moft fimple, the moft natural, and the moft eafy for calculation, according to the fyftem of numeration whw-h all Europe has employed for centuries. By a careful meafurement of the arc between Dunkirk and Mountjouy, they found the length of the metre to be equal to 443.296 lines,of the toife of Peru. The cubic decimetre of diftilled water, taken at its maximum of denfity and weight in vacuo, that is the unity of weight, was found to be 18827.15 grains of the pile of Charlemagne. By aEtual comparifon, the metre was found to be equal to 39.371 Englifh inches at 620, the temperature univcr- fally employed in the comparifon of Englifh ftandards; and upon thefe data the following tables have been conftruaed. Elements of Pharmacy. [Part h Tables of Weights and Measures, Ounces. 12 I Drachms : 96 : 8 Troy Weight. Scruples. = 288 = = 24 = = 3 - 1 = Grains. 5760 4»0 60 20 I Grammes. 372.96 7I.08 1.205 0.0647$ Ounces. 16 1 Avoirdupois Weight. Drachms. Grains. 256 n_ 7OOO 16 —- 437-5 I == 27.97S Grammes. 453-25 28.32 1.81 Measures. Pints. Ounces. 8 = 128 = 1 = 16 = Drachms. 1024 = 128 = 8 = Cub. Inch. 231 = 28.875 = I.8047 = 0.2250 = Litres. 3-78515 O.47398 0.02957 O.OO369. Appen.] Measures. 103 Meafures of Length ; the Metre being at 320, and thg hoot at 620 Millimetre Centimetre Decimetre Metre Decametre Hecatometre Chiliometre Myriornetre Englilh Inches. •°3937 •3937I 3-937io 39.37100 393.71000 : 393710000 : 39371.00000 : 393710.00000 r Mil. Fur. Yds. Feet. Inch. 0 O 10 2 9-7 0 0 I09 I I. O 4 213 t 10.2 0 1 156 0 6 Meafures of Capacity. «,.,,.,. Cubic Inches. Milhlitre =r .06103 Centilitre rr: .61028 Pecilitre rr 6.10280 Litre — 61.02800 Decalitre = 610.28000 Hecatolitre = 6102.80000 Chiliolitre = 61028.00000 Myriolitre = 610280.00000 Englifh. Tons. Hogf. Wine Gall = 0 0 O =r 0 0 2 — 0 0 26.419 — 1 0 I2.IQ = 10 I 58.9 Pints. 2-1133 5.1352 Milligramme Centigramme Decigramme Gramme Decagramme Hecatogramme Chiliogramme Myriogramme Meafures of Weight. Englilh Grains. .OI54 .1544 I.5444 154440 154.4402 : 1544-4023 : 15444.0234 : 154440.2344 : Avoirdupois. Poun. Oun. Drams. o o 5.65 o 3 8.5 2 3 5 22 j 2 4 % 104 Elements of Pharmacy. [Part I. Table of Specific Gravities, at a Medium Temperature. Diftilled water, Gases. Oxygen, Hydrogen, Sulphuretted hydrogen, Carburetted hydrogen, Light do. Nitrogen, Atmofpheric air, Nitrous oxide, Nitric oxide, Carbonic oxide, » acid, Sulphurous acid, ■ ^ Muriatic acid, Ammonia, i.o 0.0013562 0.00133929 0.0001 0.000099/11 0.000094671 0.00135 0.000804 0.000787 0.00063 0.000554 0.0012 0.00119048 0.001189 0.0012308 0.00123609 0.00197 0.001343 0.00130179 0.0014631 0.001167 0.00186161 • 0.0018454 0.00253929 0.0018856 0.00213482 0.00065357 0.00073539 L. B. K. B. L. K. C. C. c. c. K. B. L. L. B. D. D. B. .K. C. B, L. B. K. B. B. K. Oxygenized muriatic acid gas, and fluoric acid gas, unknown. L. Lavoifier. B. Briffon. K. Kirwan. C. Cruikfhank. D. Davy. Appen.] Specific Gravities. 105 Solids. Diamond - 3-52i2 1 Native fulphur, 2.0332 Melted do. - i-99°7 | Phofphorus, - 17140 Platinum tufed, 19.5000 Gold do. - 19.2581 Mercury, - 13.5681 Lead, ' - - n-3523 Silver, - - 10.4743 Bifmuth, - 9.8227 Cobalt, - - 7.8227 Copper, - 7.7880 Nickel, - - 7.3806 Tin, - - 7.2914 Caft iron, - 7.2070 Zinc, - - 7.1908 Manganefe, - 6.8500 Antimony, - 6.7021 Tungften, - 6.6785 Tellurium, - 6.1150 Molybdenum, 6. nearly. Arfenic, - 5. 7633 Uuranium, titanium, chrome, and columbium, unknown. Potafs, - 46215 Baryta, - 4. Magnefia, - 2.3298 Lime, - a.3908 Alumina, - 2. Zirconia, - 4.3 Silica, - 2.66 Soda, flrontia, gadolina, gluci- na unknown. Tallow, - 0.9419 Hogs lard, Yellow wax, White do. Spermaceti, Refin, Sandarac, Maftich, Copal, Elemi, Labdanum, Refin of Guaiac, Refin of jalap, Dragons Blood, Tacamahaca., Benzoin, Storax, Gum ammoniac, Gamboge, Olibanum, Myrrh, Scammony, Galbanum, Affdfcetida, Hepatic aloes, Socotorine aloes, Opium, Gum arabic, ----tragacanth, Exfraft of liquorice, -----,---catechu, Camphor, Caoutchouc, Cork, Fluids. Water, - 1.0000 Sulphuric acid, 2.1250 Nitric acid, ~ 1.5800 Muriatic acid, i-*94° Acetous do. - 1-0135 Acetic do. - 1.0626 Water faturated with am- monia, ©.8970 Alcohol, , - Sulphuric ether, Oil of turpentine, ------ olives, ------ almonds, Lin feed oil, Whale oil, 0.9478 0.9648 0.9686 o-9433 0.0727 1.0920 1.0742 1.0452 1.C682 1.1862 1.2289 1.2185 1.2045 1.0463 1.0924 1.1098 1.2071 1.2216 1.1732 1.3600 12354 1.2120 2-3275 1.3586 1-3795 1.3366 1*4523 1.3161 1.7228 M573 0.9887 0-9335 0.2400 0.8293 0-7394 0.8097 °-9»53 0.9170 0.9403 0.9233 106 Elements of Pharmacy. [Parti. (very foluble, proportion ( not determined. J' 15° *33 50 8-3 0.84 11.04 0.69 1.04 0.208 Strontia, cryftalized, Lime, Salts. Sulphate of Potafs, Superfulphate of potafs, Sulphate of foda, -----------ammonia, Sulphate of Magnefia, ----------- alumina, very foluble, pro- portion unknown. 5 57 0.006 1.9 0.2 6.25 5° 37-4 5° 100 unlimited. do. do. do. Table of the Solubility of Saline and other Subflances in 109 parts of Water, at the Temperature of 6o° and 2120. Acids. Sulphuric, - - unlimited. Nitric, - - do. Acetous, - - do. Pruffic, - do. Phofphoric, ~\ Acetic, Tartarous, Malic, Laftic, Laccic, Arfenic, Citric, Oxalic, Gallic, Boracic, Mucous, Succinic, Suberic, Camphoric, Benzoic, Molybdic, - - Chromic, unknown. Tungftic, infoluble. Salifiable Bafes. SodaS' fvery Soluble, proportion not known. Baryta, cryftalized, 200 100 66 2 1.25 50 8-3 4.17 o.i So any quantity. 5 3 Nitric oxide. 1 Nitrous. 2 3 Nitric. Carbon. Incombuf-tible coal. Char-coal. Carbonic oxide. Carbo-nic. Hydrogen. Water. J7-18. To. 21. Sulphur. Oxide of fulphur. Red. Sulphu-rous. Sulphu-ric. 4 Mercury. Bhck ox-ide. Yellow. Iron. Green ox-ide. Red. Arfenic. White. Arfenic. Muriatic, radical. ... . . 1 Muriat-ic. Oxyge-nized muriatic Hyperox-ygenized muriatic. Piute W. PublirtiM by Isaiah Thomas JunSIgoS C HEMICAIL S KGTN" S. Pdge 118. N° Generic Signs c ) .mi 10 11 o 12 13 a £ Oxides Adds 1^2?~3*'lfF^ 14 / 15 c 16 17 o G 18 ® 19 20 fc) 21 isr 7 X *© OS ✓ < Kg) 33 P 34 EK £ J ^ J© B 43 44 ^* M Er L z N° 22 24 Solid 23 / v-/ 23 26 27 28 29 <& 0. 1 3o 31 EL /> ^ 00 _© 32 p©" FJuid Gas i_ J r u r A 4 ^_ J) -? > 7 u V 4 1§~ 9 j$ plr yp Secondary Compounds &±J~ A /. 53 54 igj0~ 60 61 J& ^) M 0 S o 35 5 36 I 37 ^r\ 45 :>J IgLd 62 46 ^-d 47 V3& 56 57 JSU Ab 63 _@^> 64 J^) 33 s"\J a .6 48 39 49 4o 41 42 52 jfc£ 58 ^m 59 Appen.] Chemical Signs. H9 Combinations of Caloric. 22. Oxygen. 23. Nitrogen. 24. Sulphur. 25. Potafs. a6-^ce- tic acid. 27. Ice. 28. Ammonia. 29. Sulphuric acid. 30. Mer- cury. 31. White oxide of arfenic. 32. Acetite of ammonia. 1 he three columns reprefent the mode of characterizing the three Hates of aggregation of each of thefe fubftances. Primary Compounds. q*. Ammonia. 34. Carburet of iron. 35. Light hydrocarbo- nate; 36. Heavy hydrocarbonate. 37. Sulphuretted phofphorus. 38. Phofphuretted fulphur. 39. Amalgam of gold. 40. Alloy of filver and copper. 41. Glafs. 42. Liquor fihcum. Secondary Compounds. 40. Sulphite of potafs. 44. Sulphate of potafs. 45. Sulperful- phate of potafs. 46. Sulphate of alumina. 47. Superfulphate ot alumina and potafs, alum. 48. Nitrate of potafs. 49. Muriate ot ammonia. 50. Hyperoxygenized muriate of potafs. 51. Tar- trite of foda and potafs. 52. Subborate of foda. 53. Muriate ot mercury lefs oxidized, calomel. 54. Muriate of mercury more ox- idized, corrofive fublimate. 55. Green fulphate of iron. 56. Brown fulphate of iron. 57. Tartrite of antimony and potafs. 58. Subacetite of copper. 59. Acetite of copper. 60. Soap of foda. 61. Soap of ammonia. 62. Hydroguretted fuiphuret of potafs, 63. Litharge plafter. 64. Fulminating gold. 4 *l PART II. MATERIA MEDICA. THE Materia Medica comprehends emery substance, whether natural or artificial, which is employed in medi- cine. Put in most Pharmacopoeias the materia medica is confined to simples, and to those preparations which are not supposed to be prepared by the apothecary himself but to be purchased by him as articles of commerce from drug- gists and others. Much pains has been bestowed by the writers on the materia medica in attempting to form useful arrangements I of these articles. Some have arranged them according to their natural affinities ; others according to their active constituent parts ; and others according to their real and supposed virtues. Each of these arrangements have their particular advantages. The first wilVprobably be prefer- red by the natural historian, the second by the chemist, and the last by the physiologist. But no arrangement has yet been proposed which is not liable to numerous objections. Accordingly, in the Pharmacopoeias published by the Col- leges of Physicians of London, Dublin and Edinburgh, the articles of the materia medica are arranged in alpha- betical order ; and the same plan is now also adopted in almost every Pharmacopoeia of much estimation lately pub- lished on the Continent of Europe. We shall tlierefore follow the same plan, subjoining to i/ie name of each arti- 122 Materia Medica. [Part II. cle a short view of its natural, medical, and pharmaceuti- cal history. Informing our dictionary of materia medica, we shall adopt the nomenclature of the Edinburgh College, and shall include in it every article which is admitted by any one of the British Colleges. In an Appendix, we shall give a very concise account of such otlier substances, as, from their possessing a place in some respectable foreign Pharmacopoeias, or from their active properties, seem of sufficient importance to be ac- quainted with. But to conjoin the advantages of other methods, to the history of the materia medica given in al- phabetical order, we shall add some of those arrangements which seem to us to be the most useful. Part II.] Materia Medica. 123 XTlBROTANUM. (Lond.) See Artemisia. ABSYNTHIUM MAR1TIMUM. {Lond. Dub.) See Arte- misia. ------------VULGARE. {Lond. Dub.) See Artemi- sia. ACETOSA. {Dub.) ACETOSA PR.VTENSIS. {Lond.) See Oxalis. ACETUM VINI {Dub.) SeeAciDUM Acetosum. AC1DUM ACETOSUM IMPURUM. {Ed.) Syn. Acetum Vini. {Dub.) Vinegar. Impure acetous acid. Vinegar, as obtained by the fermentation of vinous liquors, befides the pure acetous acid (281) diluted with much water, con- tains tartarous acid, tartrite of potafs, mucilaginous matters, and fometimes phofphoric acid. The leaft impure is that prepared/ from white wine. It fhould be of a pale yellow color, perfeftly tranfparent, of a pleafant, fomewhat pungent, acid tafte, but with- out any acrimony. From the mucilaginous impurities which all vinegars contain, they are apt, on expofure to the air, to become turbid and ropy, and at laft vapid. This inconvenience is beft obviated by keeping it in bottles completely filled and well cork- ed. It is faid to keep better if it be boiled a few minutes before it is corked. Vinegar is fometimes adulterated with fulphuric acid. Its pref- ence is detected, if, on the addition of a folution of nitrate of ba- ryta to the fufpe&ed vinegar, a white precipitate is formed, which is infoluble in nitric acid, after having been burnt in the fire. With the fame intention of making the vinegar appear ftronger, different acrid vegetables are occafionally infufed in it. This fraud is difficult of dete£Hon ; but when tailed with atten- tion, the pungency of fuch vinegar will be found to depend rath- er on acrimony than acidity. Vinegar poffeffes ftrong antifeptic powers on dead animal and vegetable matters. Hence its employment in pickling. The fine green color fo much admired in fome vegetable pickles is of- ten improperly given them by means of copper. This poifon- ous addition is eafily detected, on dropping fome carbonate of 124 Materia Medica. [Part II, ammonia into the fufpecled vinegar, by the fine blue color, pro- duced. . Its aclion on the living body is gently ftimulant and aftringent. It promotes tranfpiration and the difcharge by urine ; and ufed moderately as a condiment, it facilitates digeflion. Vinegar is employed as a ufeful addition to drink in inflam- matory fevers. As a medicine, it is ufed in putrid difeafes, in fcurvy, and to counteract, the effects of narcotic poifons and me- phitic vapors. In the form of glyfter, it is ufed in the fame difeafes, and in obflinate conflipation. Externally, it is applied in fomentations and baths, as a ftimulant and difcutient ; and its vapor is inhaled in putrid fore throat, and diffufed through the chambers of the fick to correct, the putrefcency of the atmof- phere. ACIDUM SULPHUR1CUM {Ed.) Syn. Acidum Vitriolicum, (Lond. Dub.J Sulphuric acid, Oleum Vitrioli. The London and Edinburgh Colleges dircft, that in the fhops, its fpecifjc gravity fhould be to that of water as 18,50 to 1000; the Dublin College as 1845 to 1000. The phyfical and chemical properties of this acid have been al- ready (189.) enumerated. As it is prepared by the trading chemift, it is inferted among the materia medica. It is obtained in two ways ; by diftilling off the acid from fulphate of iron.previoufly de- prived of its water of cryftallization by heat, or by burning ful- phur in large leaden chambers, with an eighth part of nitrate of potafs to fupply the neceffary oxygen ; and in the firft way the flrongeft acid is obtained, but it is apt to contain iron or copper. By the fecond procefs it generally contains lead, which is eafily detected by mixing a portion ot the acid with three parts of diftil- led water, and If the acid be impure, a depofition will be formed. It may be rendered perfectly pure by diftillation, filling a retort half full of the common acid, and diftilling in a fand bath, gradu- ally heated as long as any acid comes over. The receiver fhould not be luted on. As its ftrength is apt to vary, the London Col- lege have directed, that in the apothecary's fhop, its fpecific grav- ity fhould be 1.850 ; the Irifh College 1.845. This want ot unU formity is to be regretted. : Sulphuric acid powerfully decompofes dead animal matter. It becomes diluted with water formed by the union of the hydrogen and oxygen ; another portion of the hydrogen combines with the azote to torm ammonia, and the carbon is feparated in the ftate of black oxide. The affinities which regulate this aftion are fo powerful,that it produces the fame effefts on the living folid, and therefore it acts upon them as a corrofive. But to its employment with this view, its fluidity is an objection, as it cannot be eafily managed. Part II,] Materia Mexico. US When fufficiently diluted, if. is an excellent tonic, checking fer- mentation, exciting appetite, promoting digeftion, and quenching thirft, and it is therefore uled wuh fuccefs in morbid acidity;wc^k- nefs, and relaxation of the ftornach. As an aftringent, it is ufed in haemorrhagies; and from its refrigerent and antifeptic properties, it is a valuable medicine in many frebrile difeafes, efpecially thofe called putrid. If taken in any confiderable quantity, or for fome time, it feems to pafs off undecompofed by the kidneys or fkin ; and it is perhaps by its ftimulant afclion on the latter, that it is ad- vantage®ufly employed internally, in pfora, and other cutaneous affections. The beft mode of prefcribing it, is to order the quan- tity of acid to be ufed, and to direct it to be mixed with as much water as will render it palatable, to which fome fyrup or mucilage may be added. To prevent it from attacking the teeth, it may be conveniently fucked through a quill, and the mouth fhould be carefully wafhed after each dofe. Externally it is ufed as a gargle, particularly in putrid fore throats, and in aphthous mouths, and as a wafh in cutaneous erup- tions, and ill conditioned ulcers. The combinations ot this acid with alcohol, aromatics, &c. and the procefles in which it is employed, will be afterwards ex- plained. ACCIPENSER STURIO, the Sturgeon. ----------------STELLATUS, the Serruga. ----------------HUSO, the lfinglafs Fifh, the Beluga, {Lond.) _______________^RUTHENUS, the Sterlet, Lond. Fifhes of the order Branchiojlegi of Cuvier. The flefh and roe, dried and falted (caviare) are alimentary. The found prepared, (ifinglafs, ichthyocolla) is officinal. {Lond. Dub.) The preparation of ifinglas is almoft peculiar to Ruffia. It is made in all places where the large fpecies of fturgeon are caught, as on the Dnieper.the Don, and efpecially on the Cafpian Sea, alfo on the Volga, the Ural, the Oby, and the Irtyfh. .That prepared from the fturgeon is reckoned the beft, and next to it that from the beluga. It alfo varies according to the mode of preparation. On the Volga and Ural, the founds are watered while frefh, and dried to a certain degree. The outer fkin is next taken off, and the inner gloffy white membrane is twitted into proper fhapes, and then completely dried. The beft is ufually rolled into the form of a fnake or heart; the fecond folded in leaves, like 3 book ; and the worft is dried without any care. In other places, as at Gu- rief, fifh glue is extracted from the founds by boiling. This is cut into flabs or plates, is perfectly tranfparent, and has the color ot am- ber. On the Okka, where the fterlet only is to be had, the founds are beat juft as they are extracted from the fifh, and dried ::;toglue. 126 Materia Medica. [Part IL Good ifinglas is white, in fome degree tranfparent, dry com- pofed of membrane not too thick, and without any fmell. The properties of ifinglas depend entirely on the gelatine, of which it principally confifts. A nutritious jelly may be prepar- ed from it. A watry folution of it is ufed as a teft of the prefence of tannin, and for the clarification of fpiritous liquors ; and it is faid to be employed for the preparation of Englifh court plaifter. See Emplafl. ichthyocol. ACONlTUxM NEOMONTANUM. Radix. Large blue Wolfsbane, Monk's hood, Aconite. The root. Linnai Species Plantarum, edit. Willdenozu,genus io6z,fpeciej 9. Polyandria Trigynia.—Nat. ord. Multifdiqucc. This is a perennial plant, found in the Alpine forefls of Carin- thia, Carniolia, and other mountainous countries in Germany, and cultivated in our gardens. Synonimes.—A. napellus of Stoerk ; Lond, Edin. Dub.and other pharmacopoeias; A. cammarum. Haller, Moench, &c. ; A. tauricum, Koelle. The characters which diftinguifh the different fpecies of aconite, are fo obfcure as to have occasioned confiderable confufion. Sto- erk, who firft employed aconite rationally as a medicine, ufed the A. neomontanum, and miftook it for the A. napellus ; other phy- ficians, who faw his error, committed a fimilar one, bv fuppofing the aconite ufed in medicine to be the A. cammarum. The real A. cammarum, when it was fometimes given, was alfo miftaken tor the A. tauricum. Thefe errors were however of little confequence as they regarded the names only, and not the article employed. The frefh plant and root are very violent poifons, producing remarkable debility, paralyfis of the limbs, convulfive motions of the face, bilious vomiting, and catharfis, vertigo, delirium, af- phyxia, death. The frefh leaves have very little fmell, but when chewed have an acrid tafte, and excite lancinating pains, and fwel- ling of the tongue. By drying, its acrimony is almoft entirely deftroyed. For medical ufe the plant muft be gathered before the ftem fhoots. When properly adminiftered, it acts as a penetrating ftimulus, and generally excites fweat, and fometimes an increafed difcharge of urine. On many occafions, it has been found a very effectual remedy in glandular fwellings, venereal nodes, anchylofis, fpina ventofa, itch, amaurofis, gouty and rheumatic pains, intermittent fevers, and convulfive dilbrders. It is commonly ufed in the form of an infpiffated juice. As foon as the plant is gathered, the juice is expreffed, and evapo* rated without any previous clarification, to the confiftence of an Part II.] Materia Medica. 121 extract. It is an unfortunate circumftance, that the powers of this medicine vary very much, according to its age. and the heat employed in its preparation. When recently prepared, its action is often too violent, and when kept more than an year it becomes totally inept. It may therefore be laid down as a univerfal rule, in the employment of this and of many other fimilar active medi- cines, to begin with very fmall dofes, and to increafe them grad- ually to the neceffary degree ; and whenever we have occafion to begin a new parcel of the medicine, we fhould again commence with the fmalleft dofe, and proceed with the fame caution as at firft. We may begin by giving half a grain of this extraft, either formed into a powder with ten grains of white fugar, or made up with any convenient addition into a pill, twice or thrice a day, and gradually increafe the dofe : Or a tincfure of aconite may be prepared by digefting one part of the dried leaves in fix parts of fpirit of wine ; the dofe of which will be at firft five or ten drops, and may be gradually increafed to forty. ACORUS CALAMUS.—{Edin.) Radix. Calamusaromaticus. {Lond. Dub.) Sweet flag. The root. Willd.g. 66o).fp. l.—HexandriaMonogynia.—'Nzt. ord.Piperita:. This plant is perennial, and grows plentifully in rivulets and marfhy places about Norwich and other parts of England, in the canals of Holland, in Switzerland, and in other countries of Eu- rope. The fhops have been ufually fupplied from the Levant with dried roots, which do not appear to be fuperior to thofe of our own growth. The root of acorus is full of joints, crooked, fomewhat flatted on the fides, internally of a white color, and loofe fpongy tex- ture ; its fmell is ftrong ; the tafte warm, acrid, bitterifh, and aro- matic ; both the fmell and tafte are improved by exficcation. This root is generally looked upon as a carminative and ftom- achic medicine, and as fuch is fometimes made ufe of in praftice. It is faid by fome to be fuperior in aromatic flavor to any other vegetable that is produced in thefe northern climes ; but this af- fertion is by no means ftriaiy true. It is, neverthelels. a fuffi-' ciently elegant aromatic. The frefh root, candied atter the man- ner directed for candying eryngo root, is faid to be employed at Conftantinople as a preservative af^ainft epidemicdifcafes. The leaves of this plant have a fweet flagrant fmell, more agreeable. though weaker than that of the roots. ADEPS ANSER1NUS. {Dub.) See Anas. ADEPS SU1LLUS. (Dub.) See Svs. 128 Materia Medica. [Part II. jERUGO. (Dub.) SeeSuBACETis Cupri. yESCULUS HIPPOCASTANUM. (Ed.) Semen Cortex. Horfe chefnut. The fruit and bark. Willd. g.717' fp> 1.HeptandriaMonogynia.—Nat.ord.Trihilatct. This is a very common and well known tree. The fruit, which probably contains much amylaceous matter, has been ufed as food for domeftic animals, and even for men in times of fear- city. But its introduction into the Edinburgh Pharmacopoeia, was probably owing to its having been ufed and recommended as a fternutatory in fome cafes of ophthalmia and headache. With this view it was drawn up the noftrils in the form of an infufion or deco£lion. The bark promifes to become a much more valuable and im- portant remedy, as an indigenous fubfHtute for the very expenfive and often adulterated Peruvian bark. Many fuccefsful experiments of its effects, when given internally in intermittent and typhus fever, and alfo when applied externally in gangrene, fufficiently warrant future trials. In powder it may be given to the extent of a fcruple and a half, or a drachm for a dofe. Buchholz prefers a folution of a drachm of the extract in an ounce of cinnamon water, ot which fixty drops are to be given every three hours. ALCOHOL. (Ed.) Spiritus vinofus reclificatus, (Lond.) Spiritus vini reclificatus (Dub.) Alcohol. Rectified fpirit of *vine. The fpirit diftilled from wine or other fermented liquors, perfectly free from any unpleafant fmell, and of which the fpe- cific gravity is to that of water as 835 to 1000, fuch as may be eafily procured. (Ed.) The London College order a fpirit of the fame fpecific gravity, and add, that it contain 95 parts of pure al- cohol, and 5 of water. The Dublin College Older it of the fpe- cific gravity 840. Alcohol forms the true charafleriftic of vinous liquors, and arifes from the decompofition of fugar, being always in propor- tion to its quantity. It is found in greateft quantity in the wines of warm countries, and in wines prepared from thoroughly ripen- ed fruit. In the fouth of France, fome wines yield a third of brandy. It is the proportion of alcohol which renders wines more or lefs generous, and prevents them from becoming four. The richer a wine is in alcohol, the lefs malic acid it contains, and, therefore, the beft wines give the beft brandv, becaufe they are free from the difagreeable tafte which the malic acid imparts to them. Old wines give better brandy than new wines, but lefs of it. Alcohol is procured from wine by diftillation ; in conducing which the follow ing rules are to be obferved : Part II.] Materia Medica. 129 i. To heat the whole mafs of fluid at once, and equally. 2. To remove all obftacles to the afcent of the vapor. 3. To condenfe the vapor as quickly as poffible. The diftillation is continued until the liquor which comes ovc; is not inflammable. Diflillers judge of the ftrength of their fpirits by the fize and durability ot the bubbles it forms, when poured from one veffel into another, or on agitating it in a veffel partly filled. Another proof is, by the combuftion of gun powder : Some of which is put in a fpoon ; it is then covered with the fpirit to be tried, which is fet on fire ; if it kindle the gun powder, it is fuppofed to be ftrong, and vice vtrfd. But a fmall quantity of fpirits will always kindle gun powder, and a large quantity never. Another proof is, by the carbonate of potafs, which attracts the water, and diffolves in it, while the alcohol fwims above. But all thefe are uncertain ; and dependence can only be put in the proof by hydrometers, or fome fuch contrivance, for afcertaining the weight of a given quantity at a given temperature. In this country, alcohol is procured from an infufion of malt, and before its rectification is termed Whifkey. In the Eaft Indies, „ arrack is diftilled from rice ; in the Weft Indies, rum from the fugar cane ; and in France and Spain, brandy from wine. Of all thefe the French brandy is the fineft fpirit ; for the others are more or lefs impregnated with effential oils, of which it is almoft impoffible to free them entirely. When any ardent fpirit is re- idiftilled to procure alcohol, the water bath is commonly ufed, which gives a more equal and temperate heat, and improves the product. Gren fays, that the addition of four pounds of well burnt charcoal, and three or four ounces of fulphuric acid, previ- ous to this rectification,* deftroys entirely the peculiar tafte ot malt fpirit ; and that a fecond rectification with one pound of charcoal, and two ounces of fulphuric acid, affords an alcohol of very great purity. But the affinity of alcohol for water is fo very ftrong, that it cannot be obtained entirely free from it by fimple diftilla- tion. We muft, therefore, abftraft the water by means of fome fubftance which has a ftronger affinity for it than alcohol has. Carbonate of potafs was formerly employed ; but muriate of lime is preferable, becaufe its affinity for water is not only very great, but by being foluble in alcohol, it comes in contact with every particle of tbe fluid. For this purpofe, one part of muriate of lime, rendered perfeftly dry by having been expofed to a red heat, and powdered after it becomes cold, is put into the ftill. Over this three parts of highly rectified fpirits are to be poured, and the mix- ture well agitated. By diflillation with a very gentle heat, about two thirds of the fpirit will be obtained in the ftate of perl'ec^y pure alcohol. r K 130 Materia Medica. [Part II. The chemical properties of alcohol have been already mention- ed, (226—230.) ti- In pharmacy it is much employed as a menftruum. Its appli- cation for this purpofe will be mentioned in the proper place. On the living body aicohol acts as a moft violent ftimulus. It coagulates all the albuminous and gelatinous fluids, and corru- gates all the folids. Applied externally, it ftrengthens the veffels, and thus may reftrain paffrve haemorrhagies. It inftarrtly contracts the extremities of the nerves it touches, and deprives them of fenfe and motion ; by this means eafing them ot pain, but at the fame time deftroying their ufe. Hence employing lpirituous li- quors in fomentations, notwithftanding the fpecious titles ot vivi- fying, heating, reftoring mobility, refolving, diffipating, and the like, ufually attributed to them, may fometimes be attended with unhappy confequences. Thefe liquors received undiluted into the ftomach, produce the fame effects, contracting all the folid parts which they touch, and deftroying, at leaft for a time, their ufe and office : If the quantity be confiderable, a palfy or apo- plexy follows, which ends in death. Taken in fmall quantity, and duly diluted, they brace up the fibres, raife the fpirits, and promote agility : If farther continued, the fenfes are difordered, voluntary motion deftroyed, and at length the fame inconvenien- ces brought on as before. Vinous fpirits, therefore, in fmall dof- es, and properly diluted may be applied to ufeful purpofes in the cure of difeafes ; whilft in larger ones they produce thre moft de- leterious effects. ALCOHOL D1LUTUM. (Ed.) Spiritus vinofus tenuior. (Lond.) Spiritus vini tenuior. (Dub.) Diluted alcohol. Spirit of wine. Proof fpirit. Alcohol mixed with an equal quantity of water, being fome- what weaker than proof fpirit ; its fpecific gravity is to that of diftilled water, 88935 to icoo. (Ed.) The London and Dublin Colleges order it of the fpecific gravity of 930, which according to the former, contains 55 parts of pure alcohol, and 45 of water. Although it be defirable that diluted alcohol fhould always be prepared, by mixing rectified fpirit with water, inftead of em- ploying an impure fpirit ot the requifite ftrength, it is hardly to be expected that apothecaries will either be at the trouble or ex- penfe. The diluted alcohol of the Edinburgh College is fome- what weaker than that of'the other two Colleges ; but befides that it is more convenient for their mode ot preparing it, this will b« attended with no difadvantage, as it is ftill fufficiently ftrong for any purpofe to which it may be applied. Part II.] Materia Medica. 131 Table of the Specific Gravities of mixtures of Alcohol and Water at 6o° Fahrenheit, according to Gilpin. Water, AlcOhol. Specific Gravities, O IOO O.835 5 95 O.83887 10 9° O.85244 *5 Is O.86414 20 80 O.87606 *5 75 O.88762 3° 70 O.89883 3.5 6,5 O9094I 40 60 0 91981 45 55 O.92961 50 5<5 O.93882 ' 55 45 O.94726 60 4© °95493 6.5 35 0.96158 7° 3° 0.96736 75 25 o-97 2 39 80 20 0.97723 85 »5 0.98213 9° 10 0.98737 95 5 o-99327 100 0 1.00000 ALLIUM. Willd. g. 626.—Hexandria Monogynia.—Nat. ord. Liliacea. Sp. 14. Allium Sativum. Radix. (Ed.) Allium. Radix. (Lond. Dub.) Garlic. The root. The garlic is a perennial bulbous rooted plant, which grows wild in Sicily, and is cultivated in our gardens. The root confifts of five or fix fmall bulbs, called cloves, inclofed/ in one common membranous coat, but eafily leparable from each other. AH the parts ot this plant, but more efpecially the roots, have a ftrong offenfive, very penetrating and diffufive fmell, and an acrimoni- ous, almoft cauftic tafte. The root is full of a limpid juice, of which it furnifhes almoft a fourth part of its weight by expreffion. The root lofes about half its weight by drying, but fcarcely any of its fmell or taile. By decoction its virtues are entirely deftroy - ed ; and by diftillation it furnifhes a fmall quantity of a yellowilh effential oil, heavier than water, which poffeffes the fenfible qual- ities of the garlic in an eminent degree. Its peculiar virtues are alfo in fome degree extracted by alcohol and acetous acid. 2 132 Materia Medica. [Part II. Applied externally, it a£ts fucceffively as a ftimulant, rubefa- cient and blifter. Internally, from its very powerful and diffufi- ble ftimulus, it is often ufeful in difeafes of languid circulation and interrupted fecretion. Hence, in cold leucophlcgmatic habits, it proves a powerful expectorant, diuretic, and, if the patient be kept warm, fud^orific ; it has alfo been by fome fuppofed to be emmenagogue. For the fame reafon in cafes in which a phlogi- ftic diathefis, or other irritability prevails, large dofes of it may be very hurtful. It is fometimes ufed by the lower claffes as a condiment, and alfo enters as an ingredient into many ot the epicure's moft fa- vorite fauces. Taken in moderation, it promotes digeftion ; but in excefs, it is ppt to produce headach, flatulence, thirft, febrile heat and inflammatory difeafes, and fometimes occafions a dif- charge of blood from the hcemorrhoidal veffels. In fevers ot the typhoid type, and even in the plague itfelf, its virtues have be,en much celebrated. Garlic is with fome alfo a favorite remedy in the cure of inter- mittents ; and it has been faid to have fometimes fucceeded in ob- it inate quartanr., after the Peruvian bark had failed. In catarrh- ous diforders of the breaft ; afthma, both pituitousand fpafmo- dic ; flatulent colics ; hy Clerical, and other difeafes proceeding from laxity of the folids, it has generally good effects ; it has like- wife been found ferviceable in fome hydropic cafes. Sydenham relates, that he has known the dropfy cured by the ufe of garlic alone ; he recommends it chiefly as a warm ftrengthening medi- cine in the beginning of the difeafe. It is much recommended by fome as an anthelmintic, and has been frequently applied with fuccefs externally as a ftimulant to indolent tumors, in cafes of deafnefs proceeding from atony or rheumatifm, and in retention of urine, arifing from debility of the bladder. Garlic may be either exhibited in fubftance, and in this way feveral cloves may be taken at a time without inconvenience, or the cloves cut into flices may be {wallowed without chewing. This is the common mode of exhibiting it for the cure of inter- mittents. The expreffed juice, when given internally, muft be rendered as palatable as poffible, by the addition ot fugar and lemon juice. In deafnefs, cotton moiftened with the juice is introduced within the ear, and the application renewed five or fix times in one day. Infufions in fpirit, wine, vinegar and water, although contain- ing the whole ot its virtues, are fo acrimonious, as to be unfit for general ufe ; and yet an infufion of an ounce of bruifed garlic in a pound of milk, was the mode in which Rozenftein exhibited it to children afflicted with worms. Part II.] Materia Medica. 133 But by far the moft commodious form for adminiftering gar- lic, is that ot a pill or bolus conjoined with fome powder, corref- ponding with the intention of giving the garlic. In dropfy, ca^ lomel forms a moft ufeful addition. It may alfo fometimes be exhibited with advantage in the form of a clyfter. Garlic made into an ointment with oils, &c. and applied ex- ternally, is faid to refolve and difcufs indolent tumors, and has by fome been greatly efteemed in cutaneous difeafes. It has like- wife fometimes been employed as a repellient. When applied under the form of a poultice to the pubis, it has fometimes prov- ed effectual in producing a difcharge of urine, when retention has arifen from a want of due action of the bladder. Sydenham aT- fures us, that among all the fubftances which occafion a derivation or revulfi©n from the head, none operates more powerfully than garlic applied to the foles of the feet ; he was led to make ufe of it in the confluent fmall pox : About the eight day, alter the face began to fwell, the root cut in pieces, and tied in a linen cloth, was applied to the foles, and renewed once a day till all danger was over. Sp. 43. Allium Cepa. Cepa. Radix. (Dub.) Onion. The root. This is alfo a perennial bulbous rooted plant. The root is a fimple bulb, formed of concentric circles. It poffeffes in general the fame properties as the garlic, but in a much weaker degree. OnioUs are, therefore, confidered rather as articles of food than of medicine ; they are fuppofed to afford little or no nourifh- ment, and when eaten liberally produce flatulencies, occafion thirft, headachs, and turbulent dreams : In cold phlegmatic hab- its, where vifcid mucus abounds, they doubtlefs have their ufe ; as by their ftimulating quality they tend to excite appetite^ and promote the fecretions : By fome they are ftrongly recommend- ed in fuppreflions of urine and in dropfies'. The chief medicinal ufe of onions in the prefent practice is in external applications, as a cataplafm for fuppurating tumors, &c. ALOE PERFOL1ATA. Gummi Refina. (Ed.) a. Aloe Barbadenfis. (Lond. Dub.) A. hepaticd. (Ed.) b. Aloe Socotorina. (Lond. Dub. Ed.) Barbadoes, or hepatic, and focotorine aloes. A gum refin. , Willd.g. 659. fp. 3. Hexandria Monogynia. Nat. ord. Liliaceae. A perennial plant, of which there are many varieties which grow in the fouth of Europe, Afia, Africa and America. But Thunberg fays, that the fiaeft aloes are prepared from the Aloe fpicata, the fecond fpecies of Willdenow, which grows at the Cape of Good Hope. 3 134 Materia Medica. [Part II. 1. Socotorine Aloes. This article is brought, wrapt in flcins, from the ifland ot So- cotora in the Indian Ocean. This fort is the pureft of the three in ufe ; it is of a gloffy furface, clear, and in fome degree pellu- cid : In the lump, of a yellowifli red color, with a purple caft ; when reduced to powder, of a bright golden color. It is hard and friable in the winter, fomewhat pliable in fummer, and grows foft between the fingers. Its tafte is bitter, accompanied with an aromatic flavor, but infufficient to prevent its being difagreeable; the fmell is not very unpleafant, and fomewhat refembles that of myrrh. It is prepared by pulling of the leaves in July, from which the juice is expreffed, and afterwards boiled and fkimmed. It is then preferved in fkins, and dried in Auguft in the fun. According to others, the leaves are cut off clofe to the ftem and hung up. The juice which drops from them without any expreffion, is af- terwards dried in the fun. 2. Barbadoes, or Hepatic Aloes. Hepatic aloes is not fo clear and bright as the foregoing fort; it is alfo of a darker color, more compact texture, and for the moft part drier. Its fmell is much ftronger and more difagreeble ; the tafte intenfely bitter and naufeous, with little or nothing of the fine aromatic flavor of the focotorine. The beft hepatic aloes comes from Barbadoes in large gourd fhells, and an inferior fort of it, which is generally foft and clammy, is brought over in cafks. Jn Barbadoe* the plant is pulled up by the roots, and carefully cleaned from the earth and other impurities. It is then fltced and cut in pieces into fmall hand bafkets and nets. Thefe nets or bafkets are put into large iron boilers or cauldrons with water, and boiled for ten minutes, when they are taken out, and frefh parcels fupplied till the liquor is ftrong and black. At this period the- liquor is thrown through a ftrainer into a deep vat, narrow at bottom, where it is left to cool and to depofit its feculent parts. Next day the clear liquor is drawn off by a cock, and again committed to a large iron veffel. At firft it is boiled brifkly, but towards the end the evaporation is flow, and requires conftant ftirring to prevent burning. When it becomes of the confiftence of honey, it is poured into gourds or calubafhes for fale, and hardens by age. 3. Fetid, Caballine or Horse Aloes. This fort is eafily diftinguifhed from both the foregoing by its ftrong rank fmell; although, in other refpeas, it agreespretty much with the hepatic, and is not unfrequently fold in its ftead. Sometimes the caballine aloes is prepared fo pure and bright, as not to be diftinguifhable by the eye even from the focotorine ; Fart II.] Materia Medica. Ioj but its offenfive fmell, of which it cannot be diverted, readily be- trays it. It has not now a place in the lift of almoft any modern pharmacopoeia, and is employed chiefly by farriers. The component parts of aloes are refin and extractive. They therefore diffolve in alcohol, proof fpirit, and proot fpirit diluted with half its weight of water ; the impurities only being left. They diffolve alfo by the affiftanceof heat in water alone ; but as the liquor cools, the refinous part fuhfides, the extractive remain- ing united with the water. The hepatic aloes is found to contain more refin and lefs extractive than the focotorine, and this lefs than the caballine. The refins of all the forts, purified by fpirit of wine, have little fmell ; that obtained from the focotorine has fcarce any perceptible tafte ; that ot the hepatic, a flight bitterifh relifh ; and the refin of the caballine, a little more of the aloetic flavor. The extractive obtained feparately from any of the kinds, is lefs difagreeable than the crude aloes : The extractive of focotorine aloes has very little fmell, and is in tafte not unpleaf- ant ; that of the hepatic has a fomewhat ftronger fmell, but is rather more agreeable in tafte than the extract of the focotorine ; the extractive of the caballine retains a confiderable fhare of the peculiar rank fmell of this fort of aloes, but its tafte is not much more unpleafant than that of the extractive obtained from the two other forts. Aloes is a bitter ftimulating purgative. Its purgative effects feems chiefly to depend on its proving a ftimulus to the rectum. in fmall dofes it empties the large inteftines, without making the ftools thin ; and likewife warms the habit, quickens the circula- tion, and promotes the uterine and hemorrhoidal fluxes. If given in fo large a dofe as to purge effectually, it often occafioas an ir- ritation about the anus, and fometimes a difcharge of bloods Aloes is much lefs frequently ufed to operate as a purgative than merely to obviate coftivenefs ; and indeed its purgative effect is not increafed in proportion to the quantity that is taken. It is frequently employed in cafes of fuppreffion of the menfes, or of the hasmorrhoidal difcharge ; .but it is particularly fervice- able in habitual coftivenefs, to perfons of a phlegmatic tempera- ment and fedentary life, and where the ftomach is op preffed and weakened. Perhaps the chief objection to aloes, in cafes of habit- ual coftivenefs, is the tendency which it has to induce and aug- ment hemorrhoidal affections : And with thofe, liable to fuch complaints, it can feldom be employed. In dry bilious habits aloes proves injurious, immoderately heating the body, and inflam- ing the bowels. $ome are ot opinion, that the purgative virtue of aloes refides en/tirely in its refin ; but experience has fhewn, that the pure refin hajs little or no purgative quality, and that the extractive part fep- I 4 136 Materia Medica. [Part. IL arated from the refinous, acts more powerfully than the crude aloes. If the aloes indeed be made to undergo long coction in the preparation of the gummy extract, its cathartic power will be con- fiderably leffened, not from the feparation of the refin, but from an alteration made in the extractive itfelf by the action of the heat and air. The ftrongeft vegetable cathartics become mild by a like treatment, without any remarkable feparation of their parts. Socotorine aloes, as already obferved, contains more extractive than the hepatic ; and hence is likewife found to purge more, and with greater irritation. The firft fort, therefore, is moft proper where a ftimulus is required, as for promoting or exciting the men. flrual flux ; whilft the latter is better calculated to act as a com- mon purge. Aloes are adminiftered either a. Simply, or b. In compofition ; 1. With purgatives. Soap, fcammony, colocynth, rhubarb. 2. With aromatics. Canella. 3, With bitters. Gentian. 4. With emmenagogues. Iron, myrrh. They are exhibited in the form of a. Powder ; too naufeous for general ufe. b. Pill ; the moft convenient form. c. Solution in wine or diluted alcohol. ALTHAEA OFFICINALIS. Radix, Folia. (Ed.) Althaa. Radix, Folium. (Lond.) Marfh mallow. The root and leaves. Willd. g. 1289. fp. 1.—Monadelphia Polyandria.—Nat. ord. Columnacea. The marfh mallow is a perennial, indigenous plant, which is found commonly on the banks of rivers, and in fait marfhes. The whole plant, but efpecially the root, abounds with a pure mucilage, free from fmell or tafte. The roots are about the thick- nefs of a finger, long and fibrous. They arc peeled and dried, and then are perfectly white. It is ufed as an emollient and demulcent, in difeafes attended with irritation and pain, as in various pulmonary complaintsi and in affeftions of the alimentary canal, and urinary organs ; andut is applied externally in emollient fomentations, gaygles and clyfBers. ALUMEN. (Lond. Dub.) See Super Sulphas AlujM- INiEet Potassje. AMMONIACUM. Gummi Refina. (Lond. Dub. Ed.) Ammoniacum. A gum refin. Part II.] Materia Medicd. 137 Ammoniacum is a concrete, gummy refinous juice, brought from the Eaft Indies, ufually in large maffes, .compofed of little lumps or tears, of a milky color, but foon changing, upon being expofed to the air, to a yellowifh hue. We have no certain ac- count of the plant which affords this juice ; the feeds ufually found among the tears refemble thofe of the umbelliferous clafs. It has been alfo alledged, and not without fome degree ot probability, that it is an exudation from a fpecies of the ferula, another fpecies of which produces the affafcetida. The plant producing it, is faid, to grow in Nubia, Abyffinia, and the interior parts of Egypt. Such tears as are large, dry, free from little (tones, feeds, or other impurities, fhould be picked out and preferred for internal ufe ; the coarfer kind is purified by folution, colature, and careful in- fpiffation ; but unlefs this be artfully managed, the gum will lofe a confiderable deal of its more volatile parts. There is often vended in the fhops, under the name of (trained gum ammonia- cum, a compofition of ingredients much inferior in virtue. Ammoniacum has a naufeous fweet tafte, followed by a bitter one ; and a peculiar fmell, fomewhat like that of galbanum, but more grateful ; it foftens in the mouth, and grows of a white col- or upon being chewed. It is not fufible ; but when thrown upon live coals, it burns away in flame ; it is in fome degree foluble in water and in vinegar, with which it affumes the appearance of milk ; but the refinous part, amounting to about one half, fubfides on ftanding. About one half of pure ammoniac is foluble in alcohol, and the folution is tranfparent ; but on the addition of water becomes milky. Water diftilled from gum ammoniac is ftronglv impreg- nated with its flavor. It therefore feems to be gummy refin, combined with an effential oil. The general action of gum ammoniac is ftimulant. On many occafions it proves a valuable antifpafmodic, deobftruent, or ex- pectorant. In large dofes it purges gently, excites perfpiration, and increafes the flow of urine. It is ufed with advantage to promote expectoration in fome pul- monary difeafes ; in dropfical affections, to augment the flow of urine, and to fupport the falivation in fmall pox. It is alfo an ufeful deobftruent ; and is frequently prefcribed for opening ob- ftructions of the abdominal vifccra, and in hyfterical disorders oc- cafioned by a deficiency of the menflrual evacuations. In long and obftinate colics, proceeding from vifcid matter lodged in the inteftines, this gummy refin has produced happy effe£ts, after pur- ges and the common carminatives had been ufed in vain. Exter- nally, it is fuppofed to foften and ripen hard tumors. A folutior? ot it in vinegar has been recommended by fome for refolving even fcirrhous fwellings. 138 Materia Medica. [Part II. It is exhibited internally, a. In folution, combined with vinegar, vinegar ol fquills.af. fafcetida, &c. b. In pills, with bitter extracts, myrrh, affafcetida. c. And externally, combined with vinegar, turpentine, com- mon plaifter, &c. AMOMUM. Willd. g. 4.—Monandria Monogynia.—Nat. ord. Scitaminca, Sp. 1. Am o m u m Zingiber. Radixficcata, et radix condi- ta ex India allata. (Ed.) Zingiber. Radix. (Lond.) Radix, Radix cendita. (Dub.) Ginger. The root, and the candied root brought from India. Ginger is a perennial plant, indigenous in the Eaft Indies, but now cultivated in the Weft India Iflands. It is cultivated^ there very much in the fame manner as potatoes are here, and is fit for digging once a year, unlefs for preferving in fyrup, when it fhould be dug at the end of three or four months, at which time it is tender and full of fap. Ginger is diftinguifhed into two forts, the black and the white. The former is rendered fit for prefervation by means of boiling water, the latter by infolation ; and as it is neceffary to felect the faireft and roundeft forts for expofure to the fun, white ginger is commonly one third dearer than black. Black ginger confifts of thick and knotty roots, internally of an orange or brownifh color, externally of a yellow grey. White ginger is lefs thick and knotty, internally of a reddifh yellow, and externally of a whitifh grey or yellow. It is firm and refinous, and more pungent than the black. Pieces which are worm eaten, light, friable, or foft, and very fibrous, are to be reje£t«d. Candied ginger fhould be prepared in India from the young and fucculent roots. When genuine, it is almoft tranfparent. That manufactured in Europe is opaque and fibrous. Ginger has a fragrant fmell, and a hot, biting, aromatic tafte. Rectified fpirit extracts its virtues by infufion, in much greater perteftion than aqueous liquors ; the latter elevate its whole fla- vor in diftillation, the former little or nothing. Ginger is a very ufeful fpice in cold flatulent colics, and in laxity and debility of the inteitines ; it does not heat fo much as thofe of the pepper kind, but its effefls are more durable. It may alfo be applied externally as a rubefacient. Sp. 3. Amomum Zedoaria. Radix. (Dub.) Long Zedoary. The root. The Zedoary is perennial, and grows in Ceylon and Malabar. The roots come to us in pieces, fome inches in length, and about a finger thick. Externally they are wrinkled, and of an afh grey Part II.] Materia Medica. 139 color, but internally are brownifh red. The beft kind comes from Ceylon, and fhould be firm, heavy, of a dark color within, and neither worm eaten hor very fibrous. It has an agreeably fragrant fmell, and a warm, bitterifh, aromatic tafte. In diftillation with water, it yields an effential oil, poffeffing the fmell and flavor of the zedoary in an eminent degree ; the remain- ing decoction is almoft fimply bitter. Spirit likewife brings over fome fmall fhare of its flavor ; neverthelefs the fpirituous extiact is confiderably more grateful than the zedoary itfelf. Sp. 7. Amomum Cardamoml'm. Sp. 10.--------Rep ens. Semen. (Ed.) Cardamomum minus. Semina. (Dub. Lond.) Leffer Cardamom feeds. The London and Edinburgh Colleges, on the authority of Son- nerat, have fuppofed thefe feeds to be the product of the latter fpecies, while the Dublin College, with Murray, Willdenow, and all the foreign, pharmaceutical writers, afcribe them to the form- er. Both fpecies are native of India. Cardamom feeds are a very warm, grateful, pungent aromatic, and frequently employed as fuch in practice : They are faid to have this advantage, that notwithftanding their pungency, they do not, like thofe of the pepper kind, immoderately heat or in- flame the bowels. Both water and rectified fpirit extract their virtues by infufion, and elevate them in diftillation ; with this dif- ference, that the tin£ture and diftilled fpirit are confiderably more grateful than the infufion and diftilled water : The watery infufion appears turbid and mucilaginous ; the tincture made in fpirit, lim- pid and tranfparent. The hufks of the feeds, which have very little fmell or tafte, may be commodioufly feparated, by commit- ting the whole to the mortar, when the feeds will readily pulver- ize, fo as to be freed from the fhell by the fieve : This fhould not be done till juft before ufing them ; for if kept without the hufks, they foon lofe confiderably ot their flavor.—The officinal prepa- tions of thefe feeds are fpirituous tinftures, fimple and com- pound : They are employed alfo as an aromatic in feveral of the ^fficiridl compofitions. AMYGDALUS COMMUNIS. Nucleus. (Ed.) a. Amygdalus dulcis. (Ed.) Amygdala dulces. (Lond. Dub.) b.---■-----amaroz. (Lond.) The almond tree. The kernel of the fruit. Willd.g. 981.7^. 2. Ico/andria Monogynia. Nat.ord. Pomacece. The fruit which affords thefe kernels, is the produce ot a tree nearly refembling the peach. It originally came from Syria and Barbary ; but is now much cultivated in the fouth of Europe. 149 Materia Medica. [Part II. The eve diftinguifhes no difference betwixt the trees which pro- duce the fweet and bitter, or betwixt the kernels themfelves ; it is faid that the fame tree has, by a difference in culture, afforded both. The almond is a flattifh kernel, of a white-color, and of a foft fweet tafte, or a difagreeable bitter one. The fkins of both forts are thin, brownifh, unpleafant, and covered with an acrid pow- dery fubftance. They are very apt to become rancid on keeping, and to be preyed on by a kind of infect, which eats out the inter- nal part, leaving the almond to appearance entire. To thefe cir- cumfiances regard ought to be had in the choice of them. Sweet almonds are ot greater ufe in food than as medicine, but they are reckoned to afford little nourilhment; and when eaten in fubftance, are not eafy of digeftion, unlefs thoroughly commi- nuted. They are fuppofed, on account of their uncfuous quality, to obtund acrimonious juices in the primas viae : Peeled fweet al- monds, eaten fix or eight at a time, fometimes give prefent relief in the heartburn. , Bitter almonds have been found poifonous to dogS and fome other animals ; and a water diftilled from them, when made of a certain degree of ftrength, has had the fame effects. Neverthe- lefs when eaten, they appear innocent to moft men, and have been not unfrequently ufed as medicines : Boerhaave recommends them, in fubftance, as diuretics which heat but moderately, and which may therefore be ventured upon in acute difeafes. The only officinal preparations of almonds are, the expreffed oil and emulfion. Both forts of almonds yield, on expreffion, a large quantity of oil. which feparates likewife upon boiling the almonds in water, and is gradually collected on the furface. The oils obtained by expreffion from both forts of almonds are in their fenfible qualities the fame. They fhould be perfectly free from fmell and tafte, and poffefs the other properties of fixed oils, (234.) The general virtues of thefe oils are, to blunt acrimonious hu- mors, and to foften and relax the folids ; hence their ufe internal- ly, in tickling coughs, heat of urine, pains and inflammations; and externally, in tenfion and rigidity of particular parts. On tritu- rating almonds with water, the oil and water unite together, by the mediation of the other matter of the kernel, and form an unc- tuous milky liquor. The milky folutions of almonds in watery liquors, commonly called emulfions, contain the oil of the fubject, and participate in fome degree of its emollient virtue; but have this advantage above the pure oil, that they may be given in acute or inflammatory diiorders, without danger of the ill effects which the oil might Part II.] Materia Medica. 141 fometimes produce ; fince emulfions do not turn rancid or acri- monious by heat, as all the oils of this kind in a little time do. As the bitter almond imparts its peculiar tafte when treated in this way, the fweet almonds are employed in making emulfions. Several un£luousand refinous fubftances, of themfelves not mif- cible with water, may by trituration with almonds be eafily mixed with it into the form of an emulfion ; and are thus excellently fit- ted for medicinal ufe. In this form, camphor and the refinous purgatives may be commodioufly taken. AMYLUM ex tritico praparatum. Wheat ftarch. The Edinburgh Colleg . have inferted ftarch as a feparate fub- ftance in their catalogue of the Materia Medica, probably confid- ering it to be a general principle common to many vegetables, al- though they point out the particular fpecies which they wifh to be employed. The general properties of ftarch have been already (255.) enur merated. As a conflituent of many vegetable fubftances, it forms a moft important alimentary fubftance. In a medical point of view, it is to be confidered as a demulcent ; and accordingly it forms the principal ingredient of an officinal lozenge, and a mucilage pre- pared from it often produces excellent effects, both taken by the mouth, and in the form of a clyfter in dyfentery and diarrhoea from irritation of the inteftines. Starch is found in many vegetables, combined with different fubftances. Fourcroy accordingly makes various fpecies ot it as combined, 1. With gluten or fibrine, as in wheat, rye, and other fimilar feeds. 2. With extraflive, as in beans, peafe, lupins, &c. 3. With mucilaginous matters, as in the potatbe and many other roots, in unripe corn. 4. With faccharine matter, in moft roots, and in corn after it has begun to germinate. 5. With oil, in the emulfive feeds, almonds, &c. 6. With an acrid principle, as in the root of the burdock, jatropha, manihot, arum, afarum, and oilier tuberous roots. AMYR1S. Willd. g. J55. Otlandria Monogynia.—Nat. ord. Dumofae. Sp. 2. Amyris Elemifera. Elemi. Refina. (Lond. Dub.) Elemi. A refin. The tree which furnifhes elemi grows in Carolina and Spanifh America. In dry weather, and efpecially at full moon, inrifions 142 Materia Medica. [Part IL are made in the bark, from which a refinous juice flows, and is left to harden in the fun. It is brought to us in long roHndifh cakes, generally wrapped up in flag leaves. The beft fort is foft- ifh, fomewhat tranfparent, of a pale whitifh yellow color, inclin- ing a little to green, of a ftrong not unpleafant fmell, refembling fomewhat that of fennel. It almoft totally diffolves in pure fpirit, and fends over fome part of its fragrance along with this menftruum in diftillation ; Diftilled with water, it yields a confiderable quantity of palecol- ored, thin, fragrant, effential oil. Its only conftituents, therefore, are refin and effential oil. It gives name to one of the officinal unguents, and is at prefent fcarce any otherwife made ufe of ; though it is certainly preferable for internal purpofes to fome others which are held in greater efteem. Sp. 18. Amyris Zeylanica. The elemi which comes from the Eaft Indies is faid to be the produce of this fpecies. Sp. 6. Amyris Gileadensis. Refina. (Ed.) Balfamum Gileadenfe. Balfam of Gilead. A refin. This article, which has alfo had the name of Balfamum Juda* icuro, Syriacum, de Mecca, Opobalfamum, &c. is a refinous juice, obtained from an evergreen tree, growing fpontaneoufly, particu- larly near to Mecca, on the Afiatic fide of the Red Sea. The beft fort ot it is a fpontaneous exudation from the tree ; and is held in fo high efteem by the Turks, who are in poffeffion of the country where it is produced, that it is rarely, if ever, to be met with gen- uine among us. From the high price fet upon it, many adultera- tions are practifed. The true opobalfamum, according to Alpi- nus, is at firft turbid and white, of a very ftrong pungent fmell, like that of turpentine, but much fweeter ; and of a bitter acrid, aftringent tafte ; upon being kept for fome time, it becomes thin, limpid, of a greenifh hue, then of a gold yellow., and at length of the color of honey. This balfam is in high efteem among the eaftern nations', both as a medicine, and as an odoriferous unguent and cofrnetic. 11 has been recommended in a variety of complaints. But in Europe it is never obtained genuine ; and as all the figns of its goodnefs are fallacious, it has been very rarely employed. Nor need we re- gret it; for any of the other refinous fluids, fuch as the balfam of Canada or Capaiba will anfwer every purpofe full as well. The dried berries of this tree were formerly kept under the ti- tle of Carpo balfamum, and the dried twigs under that of Xylo- balfamum. Although Willdenow has inferted the amyris opo- balfamum as a diftinct fpecies, he thinks they are the fame. Part II.] Materia Medtca. 143 ANAS ANSER. Adeps Anferinus. (Dub.) The goofe. The fat. The fpecific properties of the different kinds of fat are now very generally difbelieyed ; and therefore almoft the only kinds in ufe are thofe of the domeftic animals, which are eafily procur- ed. Goofe fat is foft and very greafy. It is very rarely ufed in medicine, as it poffeffes no advantage over axunge. ANCHUSA TINCTORIA. Radix. (Ed.) Anchufa. Radix. (Dub.) Alkanet. The root. Willd.g. 277. fp. .7. Pentandria Monogynia.—Nat. ord. Afpe- rifolia. This plant is a native of Europe ; it is fometimes cultivated in our gardens ; but the greateft quantities are raifed in Germany or France, particularly about Montpelier, from whence the dried roots are ufually imported to us. The alkanet root produced in England is much inferior in color to that brought from abroad ; the Englifh being only lightly reddifh, the others of a deep pur- plifh red ; and it has been fufpected, but without fufficient foun- dation, that the foreign roots owe part of their color to art. The cortical part of the root is of a duflcy red, and imparts an elegant deep red to oils, wax, and all unctuous fubftances, but not to wa- tery liquors. Alkanet root has little or no fmell ; when recent, it has a bit- terifh aftriirgent tafte ; but when dried, fcarcely any. As to its virtues, the prefent practice expects not any from it. Its chief ufe is for coloring oils, ointments, and plaifters. As the color is confined to the cortical part, the fmall roots are beft, having proportionally more bark than the large. ANETHUM. Willd.g. 560. Pentandria Digynia.—Nat. ord. Umbellata. Sp. 1. Anethum Graveolens. Semen. (Lond.) Dill. The feed. Dill is an annual umbelliferous plant, cultivated in gardens, as well for culinary as medical ufe. The feeds are of a pale yel- lowifh color, in fhape nearly oval, convex on one fide, and flat on the other. Their tafte is moderately warm and pungent; their fmell aromatic, but not of the moft agreeable kind. Thefe feeds are recommended as a carminative in flatulent colics. The moft efficacious preparations of them, are, the diftilled oil, and a tinc- ture or extract made with rectified fpirit. Sp. 3. Anethum Fceniculum. Radix, Semen. (Ed.) Fccniculum duke. Semen. (Lond. Dub.) 144 Materia Medica. [Part II. Sweet Fennel. The root and feeds. This is a biennial plant, of which there are four varieties. One of thefe. the common fennel, is indigenous to England. The fweet fennel, the variety which is officinal, grows wild in Italy, but is alfo cultivated in our gardens. The fweet fennel is fmaller in all its parts than the common, except the feeds, which are confiderably larger. The feeds of the two forts differ likewife in fhape and color : Thofe of the com- mon are roundifh, oblong, flattifh on one fide, and protuberant on the other, of a dark almoft blackiffi color ; thofe of the fweet are longer, narrower, not fo flat, generally crooked, and of a whitifh or pale yellowifh color. The feeds of both the fennels, have an aromatic fmell, and a moderately warm, pungent tafte ; thofe of thefceniculum dulce are in flavor moft agreeable, and have alfo a confiderable degree of fvveetnefs. ANGELICA ARCH ANGELIC A. Radix, Folia, Semen, Angelica. Radix, Caulis, Folia, Semen. (Lond.) Caules, Folia, eniina. (Dub.) Angelica. The root, ftalk, leaves, andfeeds. Willd.g. 543.fp. 1. PentandriaDigynia.—Nat. ord. Umbellata. Angelica is a large biennial umbelliferous plant. It grows fpontaneoufly on the banks of rivers in Alpine countries ; but for the ufe of the fhops, it is cultivated in gardens in different parts of Europe. All the parts of Angelica, efpecially the roots, have a fragrant aromatic fmell; and a pleafant bitterifh warm tafte, glowing up- on the lips and palate for a long time after they have been chew- ed. The flavor of the feeds and leaves is very perifhable ; par- ticularly that of the latter, which, on being barely dried, lofe the greateft part of their tafte and fmell; the roots are more tenacious of their flavor, though they lofe part of it with keeping. The frefh root, wounded early in the fpring, yields an odorous yellow juice ; which, flowly exficcated, proves an elegant gummy refin, very rich in the virtues of the angelica. On drying the root, this juice concretes into diftinct moleculae, which, on cutting it lon- gitudinally, appear diftributed in little veins; in this ftate, they are extracted by pure fpirit, but not by watery liquors. Angelica roots are apt to grow mouldy, and to be preyed on by infects, un- lefs thoroughly dried, kept in a dry place, and frequently aired. We apprehend, that the roots which are fubject to this inconve- nience, might be preferved, by dipping them in boiling fpirit, or expofing them to its fleam, after they are dried. Angelica is one of the moft elegant aromatics of European growth, though little regarded in the prefent practice. The root, Part II.] Materia Medici. 14$ which is the moft efficacious part, is ufed in the aromatic tincture. The (talks make an agreeable fweetmeat. ANGUSTURA. Cortex. (Ed. Dub.) Th e natural hiftory of this bark is hitherto unknown. Will- denow fufpeds that it is the bark of the magnolia Plumieri. The firft parcel of it that was imported came from Dominica, in July 1788, with an account, " that it had been found fuperior to the »* Peruvian bark in the cure of fevers." Subfequent impor- tations from the Spanifh Weftindies, either immediately or through the medium of Spain, give reafon to fuppofe, that it is the produce of South America. Now that the ifland of Trinidad, from which it is commonly imported into Europe, belongs to the Englifh, we may expect to get further information refpecting its natural hiftory. Its appearance is various, owing to its having been taken from larger or fmaller branches. The outer furface of it is more or lefs wrinkled, and covered with a greyifh coat, below which it is of a yellowifh brown : The inner furface is of a dull brown. It breaks fhort and refinous. The tafte is intenfely bitter, and flightly aro- matic, leaving a ftrong fenfeof heat and pungency in the throat and fauces. The odor is peculiar. The powder is yellow. Its predominant conftituent principles are bitter extractive mat- ter, with mucilage and a peculiar refin. It is flightly aromatic, and not at all aftringent. The extractive is very foluble in water, and the refin in alcohol. As an aromatic bitter, it has been found to be a tonic and fti- mulant of the organs of digeftion. It increafes the appetite for food, removes flatulence and acidity, arifing from dyfpepfia, and is a very effectual remedy in diarrhoea, from weaknefs of the bowels, and in dyfentery ; and it poffeffes the lingular advantage of not oppreffing the ftomach, as Peruvian bark is apt to do. It does not cure intermittents. It is exhibited, 1. In powder, in dofes of from 5 to 20 grains, either alone, or with rhubarb, magnefia, or carbonate of lime. 2. In infufion. The infufion of one drachm in four ounces of water may be ufed daily. 3. Ib tincture. 4. In watery extract. ANISUM. (Lond. Dub.) See Pimpinella. ANTHEMIS. Syngenefia Polygamia fuperflua.—Nat. orb. Compojitoz radiates. Sp. An them is Nob 1 lis. Herba etflores. (Ed.) Chamamelum. Flo res. (Dub.) Flos Simplex. (Lond.) Chamomile. The herb and flowers. L 14G Materia Medica. [Part. II. Camomile is a perennial plant, indigenous to the South of England, but cultivated in our gardens for the purpofes of medi- cine. The flowers have a ftrong not ungrateful aromatic fmell, and a very bitter naufeous tafte. Their active conftituents are bitter extractive, and effential oil. To the latter is to be ifcribed their antifpafmodic carminative, cordial, and diaphoretic effects ; to the former their influence in promoting digeftion. Camomile flowers are a very common and excellent remedy, which is often ufed with advantage in fpafmodic difeafes, in hy- fteria, in fpafmodic and flatulent colics, in fuppreffion of the men- flrual difcharge, in the vomiting of puerperal women, in the after- pains, in gout, in podagra, in intermittents, and in typhus. As camomile excites the periftaltic motion, it is ufeful in dy- fentery, but is not admiffible in all cafes of diarrhoea. From its ftimulating and fomewhat unpleafant effential oil, camomile is alfo capable of exciting vomiting, efpecially when given in warm infufion ; and in this way is often ufed to affift the action of other emetics. Externally, camomile flowers are applied as a difcutient and emollient, in the form of clyfter or embrocation, in cholic, dyfen- tary, and ftrangulated hernia, &c. Camomile flowers are exhibited, 1. In fubftance, in the form of powder, or rather of electuary, in dofes of from half a drachm to two drachms, either alone, or combined with Peruvian bark, as for the cure of intermittent fevers. 2. In infufion, in the form of tea. This may either be drunk warm, for promoting the action of emetics, or cold, as a fto- machic. 3. In decoction or extract. Thefe forms contain only the ex- tractive, and therefore may be confidered as fimple bitters. a. The effential oil may be obtained by diftillation. This pof- feffes the antifpafmodic powers in a higher degree than the fimple flowers, but on the contrary does not poffefs the virtues depend- ing on the prefence of the bitter extractive. > Sp. Anthemis Pyrethrum. Radix. (Ed.) Pyrethrum. Radix. (Lond. Dub.) Pellitory of Spain. The root. This plant, though a native of warm climates, as Barbary, bears the ordinary winters of this country, and often flowers fuc- ceflively from Chriftmas to May : The roots alfo grow larger with us than thofe with which the (hops are ufually fupplied from abroad. Pellitory root has no fenfible fmell ; its tafte is very hot and acrid, but lefs fo than that of arum ; the juice expreffed from it has fcarce any acrimony, nor is the root itfelf fo pungent when Part II.] Materia Medica. 147 frefh as after it has been dried. Water, affifted by heat, extracts fome mare of its tafte; rectified fpirit, the whole ; neither of them elevate any thing in diftillation. Its acrimony is therefore deriv- ed from a refin. The principal ufe of pyrethrum in the prefent practice is as a mafticatory, for promoting the falival flux, and evacuating the vifcid humors from the head and neighboring . parts ; by this means it often relieves the toothach, fome kinds of pains of the head, and lethargic complaints. A vinous infu- fion is alfo ufeful in debility ot the tongue. ANTIMONIUM. Stibium. Antimony. The phyfical and chemical properties of this metal have been already defcribed (167 J Antimony is found, I. In its metallic ftate, 1. Alloyed with three or four per cent, of arfenic. II. Oxidized, 2. Volatile oxide of antimony. Mongez. III. Mineralized, 3. Grey ore of antimony, (74 antimony, 26 fulphur.) Bergman. a. Compact. b. Foliated. c. Striated. 4. Plumofe ore, (antimony, arfenic, filver, fulphur.) Bergman. 5. Red ore, (hydroguretted fulphuretted antimony.) 6. White ore, (muriated antimony.) Hacquet. The grey ore of antimony (III. 3.) is the ftate in which it is officinal, and alfo that in which it is moft commonly found. Sulphuretum An riMONii. (Ed.) Antimonium. (Lond.) Stibium. (Dub.) Sulphuret of antimony. Whatever opinion may be formed of the nomenclature adopted by the Edinburgh College in general, the propriety of the change which they have introduced in this and fimilar inftances cannot be difputed : For while chemifts, according to rational principles de- fignated fimple fubftances by fimple names, the fame names con- tinued to be given by pharmaceutical writers to compound ftates of thefe bodies. To haveeftablifhed, therefore, an uniformity of nomenclature in fciences fo intimately aliied, cannot fail to be confidered as an improvement of the greateft importance. 2 14 S Materia Medica. [Part II. Although fulphuretted antimony be a natural production, yet it is commonly fold'in the form of loaves, which have been leparat- e 1 from the ftoney and other impurities ot the ore by fufior!%nd a fpecies of filtration. For the ore is melted in conical well- baked earthen pots, having one or more fmall holes in their apices. The fire is applied around and above thefe pots; and as foon as :he fulphuretted antimony melts, it drops through the boles into veffels placed beneath to receive it, while the ftoney and other im- purities remain behind. As antimony is very volatile, the mouths and joinings of the pots muft be clofed and luted. The upper part of the loaves thus obtained is more fpongy, lighter and im- pure than the lower, which is therefore always to be preferred. Thefe loaves have a dark grey color externally, but on being broken, they appear to be compofed of radiated ftriae, of a metal- lic luftre, having the color of lead. The goodnefs of the loaves is eftimated from their compa£lnefs and weight, from the largenefs anddifiinctnefsof the flriae, and from their being entirely vaporiz- able by heat. Lead has been fold for antimony ; but its texture is rather foliated than flriated, and it is not vaporizable. The prefence ol arfenic, which renders the antimony ufelefs for medi- cal purpofes, is known by its emitting the fmell of garlic when thrown upon live coals, and by other tefts mentioned under Arfe- nic. The prefence of manganefe or iron is known by their not being volatilized by a red heat. Antimony is obtained from its ores by gradually detonating in a large crucible four parts of fulphuretted antimony, three of crude tartar, and one and a half of dry nitrate ot potafs, reduced to a fine powder, and intimately mixed. The detonated mafs is then to be fufed and poured into a heated mould, greafed with a little fat, in which it is allowed to confolidate. It is then turned out, and the fcoriae are feparated from the antimony, which will weigh about onefourth part of the fuiphuret employed. The fcoriae are a mixture ot fuiphuret ot potafs and of antimony, and may be preferved tor other purpofes. Another method ot obtaining antimony, is by melting three parts of fulphuretted antimony with one of iron. The fulphur quits the antimony, and combines with the iron. Formerly antimony was given internally ; but as its action de- pended entirely on the acid it met with in the ftomach, its effects were very uncertain, and often violent. Cups were alfo made of antimony, which imparted to wine that flood in them for fome time an emetic quality. But both thefe improper exhibitions of this metal are now laid afide. Sulphuretted antimony was employed by the ancients incolly- ria againft inflammations of the eyes ; and for ftaining the eye- brows black. Its internal ufe does not feem to have been eftab- lifhed till towards the end of the fifteenth century ; and even at Part II.] Materia Medica. 149 that time it was by many looked upon as poifonous. But expe- rience has now fully evinced, that it has no noxious quality, being often ufed, particular in chronic eruptions; thai fome of the pre- parations of it are medicines of great efficacy ; and that though many of them are moft violently emetic and cathartic, yet even thefe, by a flight alteration or addition, lofe their virulence, and become mild in their operation. Antimony is at prefent the bafis of many officinal preparation/, to be afterwards mentioned. But befides thofe ftill retained, mj- ny others have been formerly in ufe, and are ftill employed by different praaitioners. We (hall here, therefore, fubjoin a table, drawn up by Dr. Black, exhibiting a diftina view of the whole! DR. BLACK'S TABLE Of THE PREPARATIONS OF ANTIMONY. Medicines are prepared cither from crude antimony, or from the pure metallic part of it, called regulus. From Crude Antimony. I. By trituration. Antimonium praeparatum. Ed. et Lond. II. By the aflion of heat and air. Flores anrimonii fine addito. Vitrum antimonii. Ed. Antimonum vitrificatum. Lond. Vitrum antimonii ceratum. Ed. Antimonium calcareo-phofphoratum, five pulvis antimonialis Ed. Pulvis antimonialis. Lond. III. By the aaion of alkalies. Hepar antimonii rnitiflimum. Regulus antimonii medicinalis. Hepar ad kermes minerale. Geoffroi. Hepar ad tincf. antimonii. Kermes minerale. Sulphur antimonii prascipitatum. Ed. et Lond. IV. By the aaion of nitre. Crocus antimonii mitiffimus, vulgo, Regulus antimonii media- natis. Crocus antimonii. Ed. et Lond. Antimonii emeticum mitius. Boerh. Antimonium uftum cum nitro, vulgo, Calx antimonii nitrata. Ed. Antimonium calcinatum. Lond. vulgo, Antimonium diaph&ret. 3 150 Materia Medica. [Part II. V. By the aaion of acids. Antim. vitriolat. Klaunig. Antim. cathartic. Wilfon. Antimonium muriatum, vulgo, Butyrum Antim. Ed. Antimonium muriatum. Lond. Pulvis algarothi, five Mercurius Vita. Bezoardicum minerale. Antimonium tartarifatum, vulgo Tartarus emeticus. Ed. , Antimonium tartarifatum. Lond. Vinum antimonii tartarifati. Ed. et Lond. Vinum antimonii. Lond. From the Regulus. This metal, feparated from the fulphur by different proceffes, is called Regulus antimonii fimple x, Regulus martialis, Regulus jovialis, &c. From it were prepared, I. By the aaion of heat and air, FJores argentei, five nix antim. II. By the aaion of nitre. Ceruffa antimonii. Stomachicum Poterii. Antiheaicum Poterii. Cardiacum Poterii. Preparations which have their name from Antimony, but fcarcely contain any of it. Cinnabaris antimonii. Tinaura ammonii. To this table of Dr. Black's, which we have left unaltered, we fhall add another, not taken from the mode of preparation, but from the nature of the produa. Antimony has been exhibited, I. In its metallic ftate. a. Antimonium. Regulus antimonii. b. Alloyed, l. With iron. Regulus antimonii martialis. 2. With tin. Regulus antimonii jovialis. 3. With tin and copper. Regulus metallorum. c. Combined with fulphur. 1. Sulphuretum antimonii. (Ed.) Antimonium. (Lond.) Stibium. (Dub.) 2. Regulus antimonii medicinalis. (Maet.) Febrifu- gum Craanii. d. Combined with fuiphuret of potafs. Hepar antimonii. Part II.] Materia Medica. 151 II. Oxidized, a. In a fmaller degree. i. Calx antimonii per fe. Cinis antimonii. 2. Flores antimonii argentini. 3. Pulvis algarothi. 4. Vitrum antimonii. Combined with wax. Vitrum antimonii ceratum. b. Combined with a little fulphur. Crocus antimonii. Crocus metallorum. c. Combined with fulphuretted hydrogen. Sulphur aura- tum antimonii. d. With hydroguretted fulphur. Kermes Minerale. e. With muriatic acid. Butyrurn antimonii. f. With tartarous acid and potafs. Tartarus emeticus. Diffolved in wine. Vinum antimoniale. g. With phofphoric acid and phofphate of lime. James's powders. k. Oxidized in a greater degree. Antimonium calcinatum. Lond. Thefe are the principal preparations of antimony. In eflimat- ing their comparative value, we may attend to the following ob- fervations. All the metallic preparations are uncertain, as it en- tirely depends on the ftate of the ftomach, whether they have no aaion at all, or operate with dangerous violence. The fuiphuret is expofed, though in a lefs degree, to the fameobjeaions. The preparations in which antimony is oxidized to the maxi- mum, are perfeaiy infoluble in any vegetable or animal acid, and are alfo found to be perfeaiy inert when taken into the ftomach. The remaining preparations of antimony, or thofe in which it is oxidized in a fmaller degree, are readily foluble in the juices of the ftomach, and a& in very minute dofes. Of its faline pre- parations, only thofe can be ufed internally which contain a veg- etable acid ; for its foluble combinations with the fimple acids are very acid and corrofive. In general, the furett and beft prep- arations of antimony are thofe which contain a known quantity of the metal in its ftate of lefs oxidifement. The general effects of antimonials ave, in fmall dofes, diaphore- fis, naufea ; in large dofes, full vomiting and purging. Some al- lege that antimonials are of moft ufe in fevers, when they do not produce any fenfible evacuations, as is faid to be the cafe fome- times with James's powder. They therefore prefer it in typhus, and emetic tartar in fynochus, in which there is the appearance at firft of more aaivity in the fyftem, and more apparent caufe for evacuation. 4 152 Materia Medica. [Part II. APIUM PETROSELINUM. Radix. (Ed.) Petrofelinum. Radix, Semen. (Lond.) Parfley. The root. (Ed.) The root and fee,d. (Lond.) Willd.g. 563. fp. 1. PentandriaDigynia.—Nat. ord. Umbellatce. Parsley is a biennial plant, and a native of the South of Eu- rope. It is very generally cultivated in this country for culinary purpofes. The feeds have an aromatic flavor, and are occafion- ally made ufe of as carminatives. The tafte of the root is fome- what fweetifh, with a light degree of warmth and aromatic flavor, and it poffeffes gentle diuretic properties. ARABICUM GUMMI. (Lond.) See Mimosa. ARBUTUS UVA URSI. Folia. (Ed.) Uva Urfi. Folia. (Lond. Dub.) Whortleberry. The leaves. Willd.g.Syifp.j.—Decandria Monogynia.—Nat.ord. Bicornes-. The uva urfi is a low fhrub, fomewhat refembling the myrtle. It feems firft to have been employed in medicine in Spain and the South of France : It is an indigenous vegetable of thefe countries, but it grows alfo in northern climates, particularly in Sweden, and on the hills of Scotland. The leaves have a bitterifh aftrin- gent tafte ; ami their latter quality is fo confiderable, that in cer- tain places, particularly in forne of the provinces of Ruffia, they are ufed for tanning leather. A watery infufion of the leaves im- mediately ftrikes a very black color with chalybeates: The uVa urfi feems firft to have been employed in medicine with a view to its aftringent power. With this intention, it was ufed under the form of decoction, for reftraining an immoderate flow of the menfes, againft other hasmorrhagies, in cafes of diar- rhoea and dyfentary, and for the cure of cutaneous eruptions. But it had fallen much into difufe till its employment was again reviv- ed by Dr. de Haen, of Vienna. He bellowed very high enco- miums on it, againft ulcerations of the kidneys, bladder and uri- nary paffages. He reprefents it as capable of curing almoft every cafe of that kind ; and even afferts, that in cafes of calculus much benefit is derived from its ufe ; patients after the employment of it paffing their water eafily and without pain. It has, however, by no means anfwered the expeaations, which, on thefe grounds, other praaitioners formed of it { But in many affeaions of the urinary organs, it has proved to be a remedy of fome ufe ; and it has been particularly ferviceable in alleviating dyfpeptic fymp- toms in nephritic and calculous cafes. It has alio been fervice- able in cyftirrhcea or catarrhus veficae; and it has been thought to be fometimes produftive of advantage in diabetes. It is fometimes ufed in the form of decoaion, but moil frequently in that of pow- Part II.] Materia Medica. 153 der, from a fcruple to a drachm for a dofe, repeated twice or thrice a day. ARCTIUM LAPPA. Radix. (Ed.) Bardana. Radix. (Lond. Dub.) Burdock. The root. Syngenefia Polygamia cequalis.—Nat. ord. Compofitcc Capitatce. This is a perennial plant, which grows wild in uncultivated places. The feeds have a bitterifh fubacred tafte ; they are re- commended as very efficacious diuretics, given either in the form of emulfion orin powder, to the quantity of a drachm. The roots tafte fweetiffi, with a light aufterity and bitteriffinefs ; they are efteemed aperient, diuretic, and fodorific ; and are faid toaa with- out irritation, fo as to be fafely ventured upon in accutediforders. Decoaions of, them have of late been ufed in rheumatic, gouty, venereal, and other diforders ; and are preferred by fome to thofe of farfaparilla. ARGENTUM. (Ed. Lond.) Argentum in laminas extenfum. (Dub.) Silver. Silver leaf. The chemical and phyfical properties of %Jver have been al- ready enumerated (157.) Silver is found, 1. In its metalic ftate : l. Pure. 2. Alloyed with gold. g.,-------------antimony. 4.--------------iron and arfenic. 2. Combined with fulphur : 1. Sulphuretted filver. 2.------------------ with antimony, iron, arfanic, and copper. g.------------------with copper. 4. ■ ---------with lead and antimony. 3. Oxidized : 1. Combined with carbonic acid and antimony. 2.---------,— with muriatic acid. 3. ————— with fulphur and oxide of antimony. Silver is admitted into the lift of Meteria Medica, only as being the bafis of a preparation to be mentioned afterwards. ARISTOLOCHIA SERPENTARIA. Radix. (Ed.) Serpentaria Virginiana. Radix. (Lond. Dub.) Virginian Snakeroot. The root. 154 Materia Medica. [Part II. Gynandria Hexandria—Nat. ord. Sarmentofix. This is a fmall, light, bufhy root, confifting of a number of firings or fibres matted together, iffuing from one common head ; of a brownifh color on the outfide, and paler or yellowifh within. It has an aromatic fmell, like that of valerian, but more agree- able ; and a warm, bitteriffi pungent tafte, very much refembling that of camphor. Its virtues are principally owing to the effen- tial oil with which it abounds. Its general a&ion is heating and ftimulant ; its particular effeas, to promote the difcharge by the fkin and urine. In its effeas it therefore coincides with camphor, but feems to be a more permanent ftimulus. It is recommended, l. In intermittent fevers, efpecially when the paroxifms do not terminate by fweating, and to affift the action of Peru- vian bark in obftinate cafes. 2. In typhus, and in putrid difeafes, to fupport the vis vitoe, and to excite gentle diaphorefis. 3. In exanthematous difeafes, when the fever is of the ty- phoid type, to fupport the aaion of the fkin, and keep out the eruption. 4. In gangrene. Externally it is ufed as a gargle in the pu- trid fore throat. It is exhibited, 1. In powder, which is the beft form, in dofes of twenty or thirty grains. 2. In infufion with wine or water. By decoaion its pow- ers are entirely deftroyed. It is often combined with Peruvian bark, or with, camphor. ARNICA MONTANA. Flores, Radix. (Ed. Dub.) Her. ba, Flos, Radix. (Lond.) German Leopard's bane. The flower, herb, and root. Syngenefia Polygamia fuperfi.ua.—Nat. ord. Compofita. radiata. Leopard's Bane is a very common perennial plant in the Alpine parts of Germany, Sweden, Lapland, and Switzerland. The flowers, which are ot a yellow color and compound, confid- ing entirely of tubular florets, are diftinguifhed from fimilar flowers, with which they are often mixed from ignorance or fraud, by the common calyx, which is fhorter than the florets, and confifts entirely ot lancetfhaped fcales, lying parallel and clofe to each other, of a green color, with purple points. The calyx of the different fpecies of Inula are compofed of briftlefhaped fcales, refleaed at the points, and befet with hairs. The florets of the genus Hypochaeris are ftrapfhaped. Part II.] Materia Medica. 15S Thefe flowers have a weak bitteriffi tafte, evidently combined with a degree of acrimony, and, when rubbed with the fingers, have a fomewhat aromatic fmell. Their aaive conltituents are not fufficiently afcertained. They evidently contain a great deal of refin, and fome effential oil. In their effetts they are ftimulat- ing, and fuppofed to be diicutient. In fmall dofes, and properly adminiftered, they poffefs very be- neficial effeas, in railing the pulfe, in exciting the aaion ot the whole fanguiferous fyftem, in checking diarrhoeas, in promoting expeaoration, and, molt paricularly in removing paralytic af- fections ot the voluntary mufcles ; but their ufe is frequently at- tended with no fenfible operation, except that in fome cafes of pafalvfis, the cure is faid to be preceded by a peculiar prickling, and by (hooting pains in the affeaed parts. When given improp- erly or in too large dofes, they excite an infupportable degree of anxiety, fhootingand burning pains, and even dangeious haemorr- hages, vomiting, vertigo and coma. For thefe dangerous fyrnp- toms, vinegar is faid to be the beft remedy. They have been recommended, 1. In paralytic diforders, in chronic rheumatifm, in retention of the urine, from paralyfis of the bladder, in amaurofis. 2. In intermittent fevers, combined with Peruvian bark. 3. In dyfentery and diarrhoea, but in fome cafes they have had bad efft-as. 4. In putrid difeafes. 5. In typhoid inflammations. 6. To promote the uterine difcharge. 7. And in internal pains, and congeflions from bruifes. In the countries where they are indigenous, the flowers of the leopard's bane, have long been a popular remedy in thefe accidents. They are contraindicated by an inflammatory diathefis, a pre- difpofition to haemorrhages, and internalcongeflions. They are beft exhibited in the form of infufion. One or two fcruples may be infufed with half a pound of water, and drunk at proper intervals. The flowers fhould be wrapt up in a piece of linen, as otherwife their down is apt to be diffufed in the liquid, and to caufe violent irritation of the throat. The dried root of this plant is about the thicknefs of a fmall quill, and fends out fibres along one fide. Externally it is rough, and of a red brown color, internally of a dirty white. Its tafte is acrid, and (lightly bitter. It is exhibited in the fame manner and circumftances as the flowers, but it is more apt to excite vo- miting. In powder, its dofe is from five to ten grains. 156 Materia Medica. [Part. II. ARSENICUM. Arfenic. The general properties of this metal have been already enu. merated. Arfenic is found, 1. In its metallic ftate: i. Alloyed with iron,, 2#------------iron gold. 3.------------cobalt. S. Oxidized : 1. Uncombined. White oxide of arfenic. 2. Combined with fulphur : a. Oxide of arfenic 90, fulphur 10, Orpiment. Yellow fulphuretted arfenic. b. Oxide of arfenic 84, fulphur 16, Realgar, Red ful- phuretted arfenic. 3. Accidified and combined ; I, With lime. 2. With copper. 3. With iron. 4. With lead. 5. With nickel. 6. With cobalt. Oxidum Arsenici. (Ed.) Oxide of arfenic. Arfenious acid (Fourcroy.) (195.) This fubftance, which was formerly named improperly arfenic, is moft generally obtained in the procefs of roafting the ores of cobalt in Saxony. The roafting is performed in a kind of rever- beratory furnace, with which a very long chimney is conneaed, lying in a horizontal direaion. The oxide ot arfenic is condenfed* in it in the form of a loofe grey powder, which, by a fecond fublimation with a little potafs, and in a great degree of heat, coalefces into a firm vitreous fublimate, which gradually becomes opaque by expofure to the air. In this ftate it is the white arfe- nic of commerce, or, as it fhould be termed, the white oxide of arfenic. For internal ufe, the lumps ot a fhining appearance and dazzling whitenefs fhould bechofen ; but it is generally offered for fale in the form of powder, which is very often mixed with chalk or gypfum. The fraud is eafily deteaed by expofing it to heat. The oxide of arfenic is entirely fublimed, and the addi- tions remain behind. As this fubftance is one of the moft virulent poifons, we fhall give a full account of its properties. It is white, compaa, brit- tle, and of a glaffy appearance. Its tafte is fweetifh, but acrid and flow in rnanifefting itfelf. It fublimes entirely when Part II.] Materia Medica. 157 expofed to 2830 Fahrenheit. When the operation is performed in clofe veffels, the oxide of arfenic affumes a glaffy appearance, which it foon lofes on expofure to the air. In open veffels it fub- limes in denfe white fumes, fmelling ftrongly ot garlic. If a pla-te of copper be expofed to the fumes, it is whitened. Oxide ot arfenic is foluble in 80 parts of water at 6o°, and in 15 at 212°. This folution has an acrid tafte, and reddens vegetable blues. It is alfo foluble in 80 parts of boiling alcohol. From either folu- tion it may be obtained regularly cryftallized in tetrahedrons. From its folutions a glafs green precipitate is feparated by a fo- lution of fulphate of iron, a white precipitate by lime water, and a yellow precipitate by any of the combinations of an alkali with fulphur, or with fulphur and hydrogen. All thefe precipitates, when expofed to a fufficient temperature, fublime entirely, and emit the fmell of garlic. When treated with nitric acid, the white oxide of arfenic is converted into arfenic acid (197.) But by far the fureft teft of the prefence of arfenic, is its re- duction by carbonaceous fubftances. With this view, a fmall quantity of any fufpeaed fubftance may be mixed with fome fatty or oily matter, and introduced within a tube clofed at the bottom, and expofed to a read heat ; if arfenic be prefent in any ftate, it will be fublimed in the form of brilliant metallic fcales. Oxide of arfenic is ufed by the dyers, as a flux in glafs making, in docimaftic works, and in fome glazes. Its fulphurets are much ufed by painters, but thefe advantages are not able to compenfate for its bad'effeas. In mines, it caufes the deftruaion of numbers who explore them ; being very volatile, it forms a dull, which affeas and deftroys the lungs, and the unhappy miners, after a languifliing life of a few years, all perifh fooner or later. The property which it poffeffes of being foluble in water, increafes and facilitates its deftruaive power ; and it ought to be profcribed in commerce, by the ftria law which prohibits the fale of poifons to unknown perfons. Oxide of arfenic is every day the inflrument by which viaims are facrificed, either by the hand of wickednefs or imprudence. It is often miftaken for fugar ; and thefe mif- takes are attended with the moft dreadful confequences. The fymptoms which charaaerize this poifon are a great conftriaion of the throat, the teeth feton edge, and the mouth ftrongly heated, an involuntary fpitting, with extreme pains in the ftomach, vomiting of glairous and bloody matter, with cold fweats and convulfions. On diffeaion, the ftomach and bowels are found to be inflam- ed gangrenous and corroded, and the blood is fluid. Soon after death livid fpots appear on the furface of the body, the nails be- come blue, and often fall off along with the hair, the epidermis feparatej, and the whole body becomes very fpeedily putrid. 158 Materia Medica. [Part II. When the quantity is fo very fmall as not to prove fatal, tre- mors, palfies, and lingering hectics fucceed. Mucilaginous drinks have been long ago given to perfons poif- oned by arfenic. Milk, fat, oils and butter, have been fuccef- fively employed. M. Navier has propofed a more direct coun- terpoifon. He prefcribes one dram of Sulphuret of potafs to be diffolved in a pint of water, which the patient is direaed to drink at feveral draughts ; the fulphur unites to the arfenic, and de- ftroys its caufticity and effeas. When the firft fymptoms are diffipated, he advifes the ufe of fulphureous mineral waters. He likewife approves the ufe of milk, but condemns oils. Vinegar which diffolves arfenic, has been recommended by M. Sage, but upon what grounds we know not. According to Hahneman a folution of foap is the beft remedy. One pound of foap may be diffolved in four pounds of water, and a cupful of this folution may be drunk lukewarm every three or four minutes. Notwithftanding, however, the very violent effeas of oxide of arfenic, it has been employed in the cure of difeafes, both as ap- plied externally and as taken internally. Externally it has been chiefly employed in cafes of cancer ; and as ufed in this way, it is fuppofed that its good effeas depend on its aaing as a pecu- liar corrofive ; and it is imagined, that oxide of arfenic is the bafis of a remedy long celebrated in cancer, which, however, is ftill kept a fecret by a family of the name of Plunket in Ireland. According to the beft conjeaures, their application con- fills of the powder of fome vegetables, particularly the ran- unculus flammula and cotula fcetida, with a confiderable portion of oxide of arfenic and fublimed fulphur intimately mixed togeth- er. This powder, made into a pafte with the white of an egg, is ap- plied to the cancerous part which it is intended to corrode; and being covered with a piece of thin bladder, fmeared alfo with the white of an egg, it is fuffered to lie on from twenty four to forty- eight hours; and afterwards the efchar is to be treated with fott- ening digeftive, as in other cafes. This application, whether it be precifely the fame with Plunket's remedy or not, and likewife arfenic in mere fimple forms, have in fome inftances been pro- duaive of good effects. Juftamond ufed an ointment compofed of four grains of white oxide of arfenic, ten grains ot opium, and a drachm oi cerate, and fpread very thin upon linen. But its aaion is tedious.- He alfo fumigated cancerous fores with a fuiphuret of arfenic with a view to deftroy their intolerable fetor, with great fuccefs. Le Fe- bure wafhed cancerous fores frequently, in the courfe of the day, with a folution of four grains of oxide of arfenic in two pounds of water. Arneman recommends an ointment ot one drachm of arfe- nic, the fame quantity of fulphur, an ounce of diftilled vinegar Part II.] Materia Medica. 159 and an ounce of ointment of white oxide of lead, in cancerous, and obftinate, illconditioned fores, and in fuppurated fcrofulous glands. The oxide of arfenic has even been applied in fubftance, fprinkled npon the ulcer. But this mode of ufing it is exceffive- ly painful, and extremely dangerous. There have been even fa- tal effeas produced from its abforption. The principal thing to be attended to in arfenical applications, is to diminifh their aaivity to a certain degree. They then, caufe little irritation or pain, but rather excite a gentle de- gree of inflammation, which caufes the difeafed parts to (lough off; aftd it has the peculiar advantage of not extending its operation laterally. No other efcharotic poffeffes equal powers in cancerous affec- tions ; but unfortunately its good effects often do not go beyond a certain length, and if in fome cafes it effeas a cure, in others it muft be allowed it does harm. While it has occafioned very con- fiderable pain, it has given the parts no difpofition to heal, the progrefs of the ulceration becoming even more rapid than before. White oxide of arfenic has alfo been recommended as a reme- dy for cancer when taken internally. With this intention, four grains of oxide of arfenic, of a clear white fhining appearance, and in fmall cryftals, is direaed to be diffolved in a pint of diftil- led water \ and of this folution the patient is to take a table fpoon- full, with an equal quantity of milk, and a little fyrup of white poppies, every morning faffing, taking care to tafte nothing for an hour after it. After this has been continued for about eight days, the quantity is to beencreafed, and the dofes more frequent- ly repeated, till the folution be taken, by an adult, to the extent of fix table fpoonfuls in the courfe of a day. Mr. Le Febure, who is, we believe, the introducer of this praaice, affirms that he has ufed it in more than two hundred inftances without any bad effea, and with evident proofs of its efficacy. But when em- ployed by others, it has by no means been found equally effica- cious. Of all the difeafes in which white oxide of arfenic has been ufed internally, there is no one in which it has been fo frequently and fo fuccefsfully employed as in the cure of intermittent fevers. Prepared in different ways, it has long been ufed in Lincolnfhire, and fome other of the fenny countries, under the name of the Arfenic drop : And it is conjeaured, that an article, which has had a very extenfive fale, under the title of the Tuftelf's aguedrop, the form of preparing which, however, is ftill kept a fecret, is noth- ing elfe but a folution of oxide of arfenic. But whether this be the cafe or not, we have now the moft fatisfaaory information con- cerning this article, in the Medical Reports ot the effeas of Arfe- nic in the cure of Agues, Remitting Fevers, and Periodic Head- achs, by Dr. Fowler, of Stafford. The medicine ho employed was the arfenite of potafs. He direas, that fixtyfour grains of oxide 160 Materia Medica. [Part II. of arfenic, reduced to a very fine powder, and mixed with as much carbonate of potafs, fhould be added to half a pound of diftil- led water, in a Florence flafk ; that it fhould then be placed in a fand heat, and gently boiled till the oxide of arfenic be com- pletely diffolved ; that after the folution is cold, half an ounce of compound fpirit of lavender be added to it, and as much diftilled water as to make the whole folution amount to a pound. This folution is taken in dofes, regulated according to the age, ftrength, and other circuraftances of the patient, from two to twelve drops, once, twice, or oftener in the courfe of the day. And in the dif- eafes mentioned above, particularly in intermittents, it has been found to be a fafe and very efficacious remedy, both by Dr. Fow- ler and by other praaitioners ; but in fom° inftances, even when given in very fmall dofes, we have found it excite violent vomit- ing, and befides this, it has alfo been alleged by fome, that thofe cured of intermittents by arfenic, are very liable to become phthifical. " It arfenic fhall ever be extenfively employed internally, it will probably be moft certain and moft fafe in its operation, when brought to a ftate of a fait readily foluble in water. Mr. Mac- quer tells us, that it may be brought to a ftate of a true neutral fait in the following manner : Mix well together equal quantities of nitrate of potafs, and of pure oxide of arfenic; put them into a retort, and diftil at firft with a gentle heat, but afterwards with fo ftrong a heat as to redden the bottom of the retort. In this pro- cefs the nitric acid is partly decompofed, and paffes over into the receiver in the ftate of nitrous acid. The oxide of arfenic is at the fame time accidified, and combines with the potafs. The pro- dua which is arfeniate of potafs, is found in the bottom of the retort, which may be obtained in the form of cryftals of a prifma- tic figure, by difolving it in diftilled water, filtering the folution through paper, evaporating and cryftallizing. Oxide of arfenic, in fubftance, to the extent of an eighth of a grain for a dofe, combined with a little of the flowers of fulphur, has been faid to be employed internally in fome very obftinate cafes of cutaneous difeafes, and with the beft effea. But of this we have no experience. ARTEMISIA.—Syngenefia Polygamiafuperflua.—Nat. ord. Compofita. difcoidew. Sp. Artemisia Abrotanum. Abrotanum. Folium. (Lond.) Southernwood. The leaves. This is a perennial fhrub, which grows readily in our gardens, though a native of the fouth of Europe. Southernwood has a ftrong fmell, which, to moft people, is not difagreeable ; it has a pungent, bitter, and fomewhat naufeous Part II.] Materia Medica. 161 tafte. Thefe qualities are very completely extrafted by reaified fpirit, the tin6ture thus formed is of a beautiful green color. They are lefs perfeaiy extraaed by watery liquors, the infufion being of a light brown color. Southernwood, as well as fome other fpecies of the fame genus, particularly the abfinthium and fantonica, has been recommended as an anthelmintic ; and it has alfo been fometimes ufed as a ftim- ulant, detergent, and fudorific. It has likewife been employed externally in difcutient and antifeptic fomentations. It has alfo been ufed under the form of lotion and ointment for cutaneous eruptions, and for preventing the hair from falling off. But al- though it ftill retains a place in the pharmacopoeia of London, it is at prefent very little employed in praaice. Sp. Artemisia Maritima. Abfinthium Maritimum. Cacumina, (Lond. Dub.) Sea Wormwood. The tops. Th i s fpecies of artemifia is perennial and herbaceous. It grows wild in fait marfhes, and in feveral parts about the feacoafls. In tafte and fmell it is weaker and lefs unpleafant than the com. mon wormwood. The tops of fea wormwood formerly entered fome of the compound diftilled waters ; but they are now rejected from thefe, and are very little employed in praaice. Sp.Artemisia Santonica. Cacumen. (Ed) Santonicum. Cacumen. (Lond.) Semina. (Dub.) Wormfeed. The tops. The feeds. All the Britifh Colleges have given this fpecies as the plant which produces thefe feeds, but it is by no means afcertained. They have been afcribed by different writers to other fpecies of the fame genus, the Judaica, the Contra, and the Auftriaca, and are even faid by Saunders to be the produce of a fpecies of Che- nopodium. The feeds themfelves are fmall, oblong, fmooth, and of a green- ifh or greyifh yellow color. As the whole head is gathered af- ter the feeds are ripe, they are mixed with the fcales of the ca- lices and bits ot (talks. Their tafte is bitter and fomewhat acrid, their fmell ftrong and difagreeable. Thofe which come from Aleppo are efteemed the bed, and thofe from Barbary the word. When they have no fmell, and a lefs intenfely bitter tafte, and are difcolored, and mixed with a longer kind ot feed, they are to be rejeaed. They are alfo adulterated with the feeds of tanfy and wormwood. The latter are eafily known, by having a light yel- low color, and refembling powdered hay more than feeds. Wormfeed is one of the oldeft and moft common anthelmintics, efpecially in the lumbrici of children. On account of their effen- tial oil, they are heating and ftimulating. , M 162 Materia Medica. [Part iL They are given to children 1. In fubftance, to the extent of ten grains, or half a drachm, finely powdered, and ftrewed on bread and butter ; or made into an eleauary with honey or treacle ; or candied with fugar ; or diffufed through milk, and taken in the morning when the ftomach is empty. a. In infufion or decoaion, but to thefe forms their bitter- nefs is a ftrong objeaion. After they have been ufed for fome days, it is cuftomary to give a cathartic, or they are combined from the beginning with rhubarb, jalap, calomef, fulphate of iron, or muriate of ammonia. Sp. Artemisia Absinthium. Folia etfummatesfiorentes. (Ed.) Abfinthium vulgare. Herba. (Lond.) Folia, cacumina. (Dub.) Common wormwood. The herb, leaves, and flowering heads. This perennial herb grows by the road fides, and on rubbifh in many parts of Britain ; and about London it is cultivated for medical ufe. Its fmell is ftrong and difagreeable ; its tafte in- tenfively bitter. Its aaive conftituents are bitter extraaive and effential oil. It is ufed in ftomach complaints, and is of great ferviceto hypochondrifts. It is alfo employed in intermittent fe- vers, in cacheaic and hydropic affeaions, in jaundice, and againft worms. Many perfons cannot fuffer the difegreeable fmell of wormwood, which is apt to occafion headach, but it may be freed from it in a great meafure by docoaion. The extraa is a pure and fimple bitter. The effential oil is ftimulating, and is fuppofed to be a powerful antifpafmodic and anthelmintic. It was former- ly much ufed for the preparation of medicated wines and ales. ARUM MACULATUM. Arum. Radix recens. (Lond. Dub.) Wakerobin. The recent root. Gynandria Polyandria.—Nat. ord. Piperita. ' This is a perennial folid bulbousrooted plant, which grows wild in fhady fituations, and by the fides of banks, iri many parts of Britain. The root is knotty, roundifh and white. When colleaed in fpring before the leaves fhoot, or in autumn af- ter flowering, it contains a milky juice of very great acrimony. Applied to the tongue, it caufes a burning heat, which lafts for many hours, and excites confiderable thirft. Thefe' difegreeable fymptoms may be relieved by buttermilk or oily fluids. Rub- bed between the fingers, it blifters and excoriates them ; it is therefore a corrofive vegetable poifon. By draining, it lofes its acrimony entirely, and becomes fimply amylaceous. It is alfo rendered perfeaiy mil4 by frequent waffling with water. Its i*artIL] Materia Medica: 16$ acrimony is therefore volatile, and eafily deftruaible ; and as it does not arife from the prefence^of an effential oil, it depends up- on a vegitable principle, different from all others, and not well underftood. It is the fame upon which the virtues of the fquill, hellebore, &c. depend. Gren has diftinguifhed it by the name of the Acrid Principle. In the recent root, the degree of acrimony is fo very uncertain, and often fo exceffive, that its effeas, as an internal remedy, can- not be depended on. The dried root is perfeaiy inert; but the roots may be kept frefh for a year, by burying them in a cellar in fand. ^ ASAFOETIDA. (Lond. Dub.) See Ferula. ASARUM EUROPIUM. A/arum. Folia. (Dub. Lond.) Afarabacca. The leaves. Willd.g. 925. fp. 1.—Dodecandria Monogynia.—rNat. ord. Sar* mentacece. * This is a perennial plant, which is a native of fome places of England, although the dried roots are generally brought from the Levant. It grows in moift and fhady fituations. It produces only two leaves, which are uniform and very obtufe. The root is fibrous, of a grey brown col«r externally, but white within. Both the roots and leaves have a naufeous, bitter, acrimonious, hot tafte ; their fmell is ftrong, and not very difagreeable. Afarabacca contains, befides its odorous principle, which is probably camphor, a portion of the fame acrid principle which we have noticed when fpeaking of arum. Upon this its virtues depend ; and as this principle is volatile, we find accordingly that afarabacca lofes much of its aaivity by decoaion and long keep- ing. Given in fubftance from half a drachm to a drachm, it evac- uates powerfully both upwards and downwards. It is faid, that tinaures made in fpirituous rnenftrua, poffefs both the emetic and cathartic virtues ot the plant : That the extraa obtained by infpif- fating thefe tinaures, acts only by vemihing, and with great mild- nefs : That an infufion in water proves cathartic, rarely emetic : That aqueous decoaions made by long boiling, and the watery ex- traa, have no purgative or emetic quality, but prove good dia- phoretics, diuretics, and emmenagogues. The principal ufe of this plant among us is as a fternutatory. The root of aforum is perhaps the ftrongelt of ali the vegetable errhines, white hellebore itfelf not excepted. Snuffed up the nofe, in the quantity of a grain or two, it occafions a large evac- nation of mucus, and raifes a plentiful fpitting. The loaves are 164 Materia Medica. [Part II confiderably milder, and may be ufed to the quantity of three, four, or five grains. Geoffroy relates, that after fnuffing up a dofe ot this errhine at night, he has frequently obferved the dif- charge from the nofe to continue for three days together; and that he has known a paralyfis of the mouth and tongue cured by one dofe. He recommends this medicine in ftubborn diforders ot the head, proceeding from vifcid tenacious matter, in palfies, and in foporifk diftempers. ASTRAGALUS TRAGACANTHA. Gummi. m (Ed.) Aflragalus Crtticus. (Lamarck.) Tragacantha Gummi. (Lond. Dub.) Gumtragacanth. Diadetphia Decandria.—Nat. ord. Papilionacea. Gumtragacanth is the produce of a very thorny fhrub1, which grows on the ifland of Candia, and other places in the Le- vant. About the end of June a fluid exudes from the Item and larger branches, which dries in the fun, and is coileaeo' by the fhep- herds on Mount Ida, from whence it is fent to Europe, under the title ot Tragacanth. It confifts of whitifh femitranfparent vermiform pieces, fcarce- ly a line in thicknefs, without tafte or fmell. There is alfo a dirty yellow, or brownifh kind, which is not fit for medical purpofes. Tragacanth is a true gum, and is principally employed as a de- mulcent to blunt acrimonies, and as a pharmaceutical agent. ATROPA BELLADONNA. Folia. (Ed.) Belladonna. Folia. (Dub.) Deadly Nightfhade. The leaves. Willd.g. $i.fp. 2.—Pentandria Monogynia.—Nat. ord.-oWi- nacex. The Deadly Nightfhade is a perennial plant, with a herba- ceous Item, which is indigenous both in mountainous and woody fituations in this country, and often cultivated in gardens. The whole plant is poifonous, and the berries, from their beautiful ap- pearance, have fometimes proved fatal to children. The fymptoms excited are, a drynefs of the mouth ; a trembling of the tongue ; a very diftreffing thirft; a difficulty of fwallowing ; fruitlefs efforts to vomit; and great anxiety about the praecordia. Delirium then comes on, with knafhing of the teeth and convulfions. The pupil remains dilated, and is not fenfible even to the ftimulus of light. The face becomes tumid, and of a dark red color. The jaws are frequently locked. Inflammation attacks the cefophagus, ftomach and inteftines, fometimes extending to the mefentery, lungs and liv- er, accompanied with violent pains in the abdomen. The ftomack Part II.] Materia Medica. 165 is very infenfiblf to ftimulus, and the periftaltic motion of thein- teftines is deftroyed. General relaxation, palfy efpecially, of the lower extremities, convulfions, vertigo, blindnefs, coma, and death, fucceed. The body foon putrifies, fwells, and becomes marked with livid fpots ; blood flows from the nofe, mouth and ears, and the ftench is infufferable. On diffection, the blood is found to be fluid, the interlines are inflated and inflamed, or erod- ed and gangrenous. The beft method ot cure is to excite vomit- ing as foon as poffible, by emiticsand tickling the fauces ; to evac- uate the bowels by purgatives and glyfters ; and to give, largely, vinegar, honey, milk and oil. In fome children who recovered by this treatment, the delirium was fucceeded by profound fopor, accompanied with fubfultus tendinum ; the face and hands became pale and cold, and the pulfe fmall, hard and quick. Their recov- ery was flow, and the blindnefs continued a confiderable time, but at laft went off. Yet this virulent poifon, under proper management, may be- come an excellent remedy. Befides a very remarkable narcotic power, it poffeffes confiderable influence in promoting all the ex- cretions, particularly by fweat, urine, and it is alfo faid by faliva ; but its exhibition requires the greateft caution ; for it is apt when continued for any length of time, even in fmall dofes, to caufe drynefs and tenfion ot the throat and neighboring parts, vertigo, dimnefs of fight, and even temporary blindnefs. When any of thefe fymptoms occur, its ufe muft be fufpended for fome time, and afterwards refumed in fmaller dofes. Deadly nightfhade has been exhibited l. In feveral febrile difeafes ; in obftinate intermittents; and in the plague. *. In inflammations ; the gout. 3. In coraatofe difeafes ; in palfy and lofs of fpeech from apoplexy. ^. In fpafmodic difeafes; in chorea ; epilepfy; chincough; hydrophobia ; melancholy, and mania. 5. In cacheaic affeaions ; in dropfies and obftinate jaundice. 6. In local difeafes; in amaurofis ; in fcirrhus, and cancer. Deadly nightfhade is beft exhibited in fubftance, beginning with a very fmall dofe of the powdered leaves or root, fuch as the fourth or eighth part of a grain for children, and one grain for adults, to be repeated daily, and gradually increafed. In hydro- phobia, Miinch gave the powdered root every fecond morning, to the extent of from one to five grains to children, and fourteen or fifteen grains to adults. The watery infufion is alfo a powerful remedy. One fcruple of the dried leaves are infufed in ten ounces of warm water, and drained after cooling. At firft two ounces of this may be given 3 166 Materia Medica. [Part II, daily to adults, and gradually increafed until thevtenfion of the throat fhews that it would be imprudent to go farther. The watery extraa is not a judicious preparation. Externally, the powdered leaves are applied as a narcotic to di- minifh pain, and to cancerous and illconditioned fores. From its effea in permanently dilating the pupil, Profeffor Reimarus pro- pofed, and tried with fuccefs, the dropping a little of the infufion into the eye, a few hours before performing the operation for the cataraa, with the view of facilitating the operation. AURANTIUM HISPALENSE. (Lond. Dub.)See Citrus. AVENASATIVA. Semen. (Ed.) Avena. Semen. (Lond.) Oats. The feed. * Willd.g. \Ai.fp. 13.—Triandria Digynia.—Nat. ord.Gramina* This is a well known annual plant, which is very generally cultivated in northern countries, and in many places furnifhes their principal fubfiftence. When fimply freed from the hufks, this grain gets the name of groats, but it is more frequently ground into meal. Groats are made into, broths. Meal is baked! with fait and water into cakes, or with the fame additions, is boil- ed to form porridge. An infufion of the hufks in water, allowed to remain till it become acidulous, is boiled down to a jelly, which is called fowins. In all thefe forms it is nutritious, and eafy of digeftion. Gruels or decoaions, either of groats or oatmeal, either plain or acidified, or fweetened, form an excellent drink in febrile dif- eafes, diarrhoea, dyfentery, &c. and from their demulcent prop- erties, prove ufeful in inflammatory diforders, coughs, hoarfe- nefs, roughnefs, and exulcerations of the fauces. BALSAMUM CANADENSE. (Lond. Dub.) SeePiNUS Balsamea. BALSAMUM COPAIBA. (Dubj Balfamumcofaiva. (Lond.) See Copaifera Officinalis. » BALSAMUM PERUVIANUM. (Lond. Dub.) See My- roxylon Peruiferum. BALSAMUM TOLUTANUM. (Lond. Dub.) SeeToLUi^ fera Balsamum. * BARDANA. (Lond. Dub.) See Arctium Lappa. BARILLA. (Lond. Dub.) See Carjsonas SodjE, Part II.] Materia Medica. 167 BECABUNGA, (Dub.) Beccabunga. (Lond.) See Veroni- ca Beccabunga. BELLADONNA. (Dub.) See Atropa Belladonna. BENZOE. (Lond.) Benzoinum. (Dub.) SeeStyrax Ben- zoin. BERBERIS VULGARIS. Berberis. Fruilus. (Dub.) Barberry. The fruit. Willd. g. 6jj.fp. 1.—Hexandria Monogynia.—Nat. ord. Trihi- lata. The barberry is a fmall tree, or rather a large buffi, covered with an afhcolored bark, under which is contained another of a deep yellow : The berries are of an elegant red color, and con- tain each two hard brown feeds. It grows wild on chalky hills in feveral parts of England ; and is frequently planted in hedges and in gardens. The outward bark of the branches and the leaves have an aftringent acid tafte ; the inner yellow bark, a bitter one. This laft is faid to be ferviceable in the jaundice ; and by fome to be an ufeful purgative. The berries contain a very acid red juice, which confifts chief- ly of. malic acid. In warm countries it forms a ufeful and pleafant addition to antiphlogiftic drinks in fluxes and in malignant fevers, for abating heat, quenching third, raifing the ftrength, and pre- venting putrefaaion. They alfo form a very elegant fyrup or preferve, which may be employed with advantage in the fame difeafes. BETULA ALBA. Succus. (Dub.) The birch tree. The juice. Monoccia Tetrandria.—Nat. ord. Amentacea. This tree grows wild in moft woods : Its bark is aftringent. Upon deeply wounding or boring the trunk of the tree in the beginning of fpring, a fweetifh juice iffues forth, fometimes, it is faid, in fo large quantity, as to eqaal in weight the whole tree and root : One branch will bleed a gallon or more in a day. This juice is chiefly recommended in.fcorbutic and fimilar diforders : Its moft fenfible effea is to promote the urinary difcharge. BISTORTA. (Lond. Dub.) SccPolygonumBistorta. BITUMEN PETROLEUM. (Ed.) Petroleum. (Lond.) Petroleum Barbadenfe. Refina. (Dub.) i 168 Materia Medica. [Part II, Rock oil. Barbadoes tar. Bitumen is now employed as the generic name for feveral in- flammable bodies of different degrees of confiftency, from perfect fluidity to that of a brittle but very fufible folid, and of little fpe- cific gravity. They are infoluble in alcohol-or in water, combine with effential oil&and fulphur, decompofe only a fmall proportion of nitrate of potafs by deflagration, and on inflammation leave lit- tle or no refiduum. Sp. 1. IN aphtha. It is nearly as colorlefs, tranfparent, and fluid as water. Specific gravity 0729 to 0.847, of a highly penetrat- ing, yet not diiagreeable fmell, fomewhat like that of rectified oil of amber, very volatile, and remaining fluid at o° Fahrenheit. Sp. 2. Petroleum. Not fo fluid, tranfparent, or colorlefs, as the former ; fmell lefs pleafant. Specific gravity 0.878. Sp.3. Mineral Tar. Vifcid; of a dark color; fmell fometime ftrong, but often faint. Specific gravity i.t. Sp.4. Mineral Pitch ; maltha. Brittle in cold weather ; of a dark color; opaque. Specific gravity probably 1.07. Sp.g. Asphaltum. Very brittle ; fraaure conchoidal ; glaffy luftre ; no fmell unlefs when melted or heated. Specific gravity 1.07 to 1.165. Fufible and inflammable. According to Mr. Kirwan and Mr. Hatchett, the firft fpecies, by expofure to the air, and gradual decompofition, paffes fucceffively through the intermediate ftates, till at laft it is converted into af- phaltum. When partially decompofed, the remaining naphtha may be feparated by diflillation from the.fuperabundant charcoal. From the different pharmacopoeias having been publifhed before the fpecific charaaers were properly afcertained, there is fome confufion with regard to the fpecies which is officinal. The Lon- don College name the fecond, and the Dublin College the third ; but the latter err greatly in calling it a refin ; while the Edinburgh College incorrectly give petroleum Barbadenfe, which belongs to the third fpecies, as a fynonime of bitumen petroleum, which is the fecond. The firft fpecies is found abundantly in Perfia ; but what we receive comes from the dutchy of Modena in Italy. It is very rarely met with in the (hops ; the fecond, mixed with a little of the third and fome fubtile oil, is ufually fent us inftead of it. Petroleum is at prefent very rareiy employed,as a medi- cine, though if the finer kinds could be procured genuine, they feem to deferve fome notice : They are more agreeable than the oil of amber, and milder than that of turpentine ; of the virtues of both of which they participate. They are principally recom- mended by authors for external purpofes, againft pains and aches, in paralytic complaints^ and for preventing chilblains. For thefe intentions, fome of the more common mineral oils have been made ufe of with good fuccefs i an oil extraaed from a kind of ftone- part. II.] Materia Medica. 169 coal has been extolled amotig the common people, under the name of Britifh oil, for rheumatic pains, &c. even this is often coun- terfeited by a fmall portion of oil ot amber added to the common expreffe i oils. The Barbadoes tar is found in feveral of the Weft India iflands, where it is efteemed by the inhabitants of great fervice as a fudo- rific, and in diforders of the bread and lungs ; though in cafes of this kind, attended with inflammation, it is certainly improper ; they likewife apply it externally as a difcutient, and for prevent- ing paralytic diforders. BOLETUS IGNIAR1US. (Ed.) Agaricus chirurgorum. Off. Female agaric, or agaric ot the oak, called, from its being very eafily inflammable, Touchwood, or Spunk. Cryptogamia Fungi.—Nat. ord. Fungi. This fungus is frequently met with, on different kinds of trees, in Britain, efpecially the cherry and plumb ; and is faid to have been fometimes brought into the (hops mixed with the true agaric of the larch ; from this it is eafily diftinguiffiable by its greater weight, dufky color, and mucilaginous tafte, void of bitternefs. The medullary part of this fungus, beaten foft, and applied exter- nally, has been much celebrated as a ftyptic; and faid to reftrain not only venal but arterial haemorrhages, without the ufe of liga- tures. It does not appear, however, to have any real ftyptic power, or to aa any otherwife than dry lint, fponge, or other fott fungous applications. It is beft when gathered in Auguft or Sep- tember. BORAS SOD^E. (Ed.) See Subboras Sodm. BOLUS GALLICUS. (Lond.) French bole. Boles are earthly aggregates, confifling chiefly of filiceous and argillaceous earths. They are lefs coherent and more friable than pure clay, more eafily diffufed through water, and more freely fubfidiog from it. They feel greafy to the touch, adhere flightly to the tongue, and break down in the mouth, impreffing a light fenfe of aftringency. A great variety of thefe fubftances were formerly ufed in medicine, but the French bole alone is now re- tained in the London Pharmacopoeia. If is of a pale red color, variegated with irregular fpecks or veins of white and yellow. Thefe earths have been recommended as aftringent, fudorific, and alexipharmic ; and they have been ufed in diarrhoeas, dyfen- teries, haemorrhages, and in malignant and peftilential diftempers. In inteftina! fluxes, and complaints in the firft paffages, from thin acrimonious humors, they may doubtlefs be of fome ufe; but 170 Materia Medica. [Part II, the virtues afcribed to them in the other cafes appear to have na foundation. BORAX. {Dub. Lond.) See Subboras SodjE. BRYONIA ALBA. (B. dioica, Jacquin, Withering.) Bryena. Radix. (Du(>.) Bryony; Wild vine. The root. Monoecia Syngenefia,—Nat. ord. Cucurbitacea. This is an indigenous perennial plant, growing on dry banks, under hedges, and climbing upon the bufhes. The roots are large fometimes as thick as a man's thigh ; their fmell, when frefh, is ftrong and difagreeable; the tafte naufeoufly bitter, acrid, and biting; the juice is fo fharp as in a little time to excoriate the Ikin ; in drying they lofe great part of their acrimony, and almoft the whole of their fmell. Byrony root is a ftrong irritating cathartic; and as fuch has fometimes been fuccefsfully exhibited in maniacal cafes, in fome kinds of dropfies, and in feveral chronical diforders. An extraft prepared by water aas more mildly and with greater fafety than the root in fubftance ; given from half a drachm to a drachm, it is faid to prove a gentle purgative, and likewife to operate powerfully by urine. The frefh root applied externally, is faid to be a power- ful difcucient in oedematous fwellings. Befides the acrid principle on which the aaivity ©f thefe roots depends, they contain a great deal of ftarch, which was formerly ufed under the title of Faculty radicis bryoma. BUBON GALBANUM. Gummirefina. (Ed.) Galbanum. Gummirefina. (Lond. Dub.) Galbanum. A gumrefin. Willd.g. 5\6.fp. 2. Pentandria Digynia.—Nat. ord. Umbellate. This plant is perennial, and grows in Africa. It abounds with a milky juice, which fometimes exudes from the joints of the old plants, but is more frequently obtained by cutting them acrofs fome inches above the root. The juice which flows from the wound foon hardens, and is the galbanum which is brought to us from Syria and the Levant. The beft fort of galbanum confifts of pale colored pieces, about the fize of a hazel nut, which on being broken appear to be com- pofed of clear white tears, of a bitteriffi acrid tafte, and a ftrong peculiar fmell. But it moft commonly occurs in agglutinated maffes, compofed of yellowiffi or reddifh and clear white tears, which may be eafily torn afunder, mixed with feeds and leaves, of the confiftence of firm wax, foftening by heat, and becoming brittle by cold. What is mixed with fand, earth and other im- purities, and is of a brown or blackifh color, interfperfed with no Part II.] Materia Medica. ' 171 White grains, of a weak fmell, and of a confiftence always foft, is bad. Galbanum is almoft entirely foluble in water, but the folution is milky ; neither do wine or vinegar diffolve it perfeaiy. Al- cohol has very little aaion upon it. It is not fufible ; but fur- nifhes a confiderable proportion of effential oil when diftilled with water. It is therefore principally compofed of gum and effential oil. Galbanum agrees in virtue with gum ammoniacum ; but is gen- erally accounted lefs proper in afthmas, and more fo in hyfterical complaints. It is exhibited in the form of pills or emulfion, to the extent of about a drachm. Applied externally, it is fuppofed to refolve and difcufs tu- mours, and to promote fuppuration. CALAMUS AROMATICUS. (Lond.) See Acorus. CALX. (Lond.) Calx viva. (Ed.) a. Ex lapide calcareo. b. Ex teftis conchyliorum. Calx, recens ufia. (Dub.) Quicklime, recently burnt. Lime is a fimple fubftance, the properties of which have bee» already enumerated (lot-) It is fcarcely found in nature un- combined, but is eafily prepared from any of its carbonates, ei- ther minerial or animal, by the aaion of fire, which firft expels the water, and then deftroys any animal matters which may be pre- fent, and laftly, expels the carbonic acid. The procefs improp- erly termed the burning of lime. The produft is lime, or, as it is commonly called, quicklime. If about half its weight of water be poured upon lime, a great increafe of temperature takes place, fteam is produced, and the lime crumbles down into a dry powder, fomewhat increafed in weight by the prefence of part of the water,which has been folid- ified by the lime; and to the caloric of fluidity, which is expelled during the converfion of the water into a folid, the great increafe of the temperature is owing. Lime in this ftate is faid to be flak- ed. If more water be poured upon flaked lime, there is no new evolution of caloric ; but if the water amount to 700 times the weight ot the lime, the lime is completely diffolved. This folu- tion is termed Lime water. As lime quickly attraas moifture and carbonic acid from the atmofphere, it fhould be always recently prepared ; and when kept, it ftiould be preferved in very clofe bottles. Xime fhould not effervefce with acids, and fhould be entirely foluble in water. 172 Materia Medica. [Part. II. On the living body lime aas as an efcharotic, and as fuch it was formerly applied to illconditioned and obftinate fores. But it is now principally ufed in pharmacy for the purpofe of forming lime water, and as a chemical agent in feveral preparations. CAMPHORA. (Lond. Dub.) SeeLAURUS. CANCER. Chela. (Lond.) Calculi oculi dicli; Chela. (Dub.) The crab. A genus of cruftaceous infeas. Sp. Cancer Astacus. Lapilli. Ed. The craw fifh. Crab's ftones, vulgarly called Crab's eyes. Crab's ftones are generally about the fize of peas, or larger; of a fpherical fhape, but a little flatted on one fide ; of a white col- or ; but fometimes with a reddifh or bluifh caft, and internally of a laminated ftruaure. Thefe concretions are found in the ftomach, one on each fide, * at the time when the crab changes its (hell, and alfo renews the inner membrane of the ftomach, which commonly happens in the month of Auguft. They afterwards gradually difappear, and no ftones are found after the new ffiell has acquired its full degree of firmnefs. They therefore feem to furnifh the materials for the in- duration of the new fhell. They are brought in great numbers from Poland and Ruffia, efpecially from the province of Aftracan, where the craw fifh are either bruifed with wooden mallets, or laid up in heaps to putrify, when the flefh is wafhed away with water, and the ftones picked out. They confift of carbonate ot lime, combined with a little phof- phate of lime and gelatine. The quantity of the two laft is too fmall, and their aaion on the living body too inconfiderable, to make any confiderable difference in medical properties, between thefe concretions and foft carbonate of lime, as it occurs in the mi- neral kingdom. Crab's ftones are faid by moft Writers on the materia medica to be frequently counterfeited with tobacco pipe clay, or compofi- tions ot chalk with mucilaginous fubftances. This piece of fraud, if really prafctifed, may be very eafily difcovered ; the counter- feits wanting the leafy texture which is obferved upon breaking the genuine ; more readily imbibing water ; adhering to the tongue; and diffolving in vinegar, or the ftronger acids, diluted with water, either entirely, or not at all, or by piecemeal ; whilft the true crab ftones, digefted in thefe liquors, become foft and. tranfparent, their original form remaining the fame as the organ- ization of the gelatine is not altered by the acid. Sp. Cancer Pagurus. Chela. (Ed.) The black clawed crab. The claws. Part II.] Materia Medica. 173 This fpecies of crab inhabits the fea, and is found efpecially in the North Sea. Its claws are yellow, tipt with black, and in every refpea they refemble the former article. CANELLA ALBA. Cortex. (Lond. Ed. Dub.) Canella alba. The bark. Willd. g. qAi.fp. 1. Dodecandria Monogynia.—Nat. ord. Ole- racea. The Canella alba, or, as the Dublin College name it, the Win- terania Canella, is a tall tree which is very common in Jamaica, and other Weft India iflands. The canella is the interior bark, freed from an outward thin rough one, and dried in the ffiade. The ffiops diftinguiffi two forts of canella, differing from each other in the length and thick- nefs of the quills ; they are both the bark of the fame tree, the thicker being taken from the trunk, and the thinner from (he branches. It is brought to us rolled up in long quills, thicker than cinna- mon, and both outwardly and inwardly of a whitiffi color, light- ly inclining to yellow. It is a warm pungent aromatic, not of the moft agreeable kind ; nor are any of the preparations of it very grateful. Infufions of it in water, are of a yellowiffi color, and fmell of the canella; but they are rather bitter than aromatic. Tinaures in reaified fpirit have the warmth of the bark, but little of its fmell. Proof fpirit .diffolves the aromatic as well as the bitter matter of the canella, and is therefore the beft men- ftruum. Canella alba is often employed where a warm ftimulant to the ftomach is neceffary, and as a corrigent of other articles. It is ufeful as covering the tafte of fome other articles. It muft not be confounded with the bark of the Wintera aro- matica. CANTHARIDES. (Lond. Dub.) See Meloe. CAPSICUM ANNUUM. FruRus. (Ed.) Piper Indicum. Capfula. (Lond. Dub.) Cockfpur pepper. The pod. Willd. g. 384.^. 1. Pentandria Monogynia.—Nat. ord. Sol*- nacea. This is an annual plant, a native of South America, but culti- vated in large quantities iu our Weft India iflands ; and it will even ripen its fruit in this climate. The pods of this fpecies are long, pointed and pendulous, at firft of a green color, and afterwards of a bright orange red. They are filled with a dry loofe pulp, and contain many fmall, flat kidney ffiaped feeds. The tafte of capficum is extremely pun- gent and acrimonious, fetting the mouth as it were on fire. i74 Materia Medica. [Part If; Its pungency is not owing to the prefence either of the acrid principle, (See Allium) orof an effential oil, both «f which are volatile, but to a fixed refinous fubftance ; for it is not diminifhed by drying, and may be extraaed by alcohol. Cayene pepper is an indifcriminate mixture of the powder of the dried pods of many fpecies of capficum, but efpecially of the Capficum frutefcens or bird pepper, which is the hotteft of all. Thefe peppers have been chiefly ufed as a condiment. They prevent flatulence from vegetable food, and have a warm and kindly effea in the ftomach, poffeffingall the virtues of the orien- tal fpices, without, according to Dr. Wright, producing thofe com- plaints of the head which the latter are apt to occafion. An abufe of them, however, gives rife to vifceral obftruaions, efpecially of the liver. But of late they have been employed alfo in the praaice of medicine. There can belittle doubt that they furnifh us with one of the pureft and ftrongeft ftimulants which can be introduced into the ftomach ; while at the fame time they have nothing ot the narcotic effeas of ardent fpirit. Dr. Adair Maki- trick, who was perhaps the firft that employed them as a medi- cine, direas their being given to the extent of fix or eight grains under the form of pills, or under the form of tinaure made by in- fufingh'alf an ounce in a pound of reaified fpirit, and giving of this from one to three drachms diluted for a dofe. He has found them ufeful in a variety of affeaions, particularly in that morbid difpo- fition which hecalls the Cachexia Africana, and whichhe confiders as a moft frequent and fatal prcdifpofkion to difeafe among the flaves. Dr. Wright fays, that in dropfical and other complaints, where chalybeates are indicated, a minute portion of powdered capfi- cum forms an excellent addition, and recommends its ufe in le- thargic affeaiorts. This pepper has alfo been fuccefsfully em- ployed in a fpecies of cynanche maligna, which proved very fatal in the Weft Indies, refilling the ufe of Peruvian bark, wine, and the other remedies commonly employed. In tropical fevers, coma and delirium are common atten- dants ; and in fuch cafes, cataplafms of capficum have a fpeedy and happy effea. They redden the parts, but feldom blifter, unlefs kept on too long. In ophthalmia from relaxation, the diluted juice of capficum is a fovereign remedy. CARBONAS. Carbonate is a generic name for the combinations of the carbonic acid with earths, alkalies, and metalic oxides. The nature of thefe fubftances was totally unknown, until the year 1756, when thegenius of Dr. Black at once removed the veil, and displayed to his cotemporaries a new and immenfe field, in which the moft important difcoveries might be made; and to their hut ii.] Materia Medica. 17S ardor in cultivating it, we are indebted for the prefent ftate of chemical knowledge. Before the brilliant epoch we have mentioned, the carbonates were fuppofed to be fimple bodies; and the faa of their acquiring new and cauftic properties by the aaion of fire, was attempted to be explained by fuppofing that the particles of the fire combined with them. Dr. Black, however, demonftrated by proofs which carried univerfal conviaion along with them, that thefe bodies in their cauftic ftate are fimple, and that their mildnefs is owing to their being combined with an acid, to which the name of carbon- ic is now given. The moft general character of the carbonates, in their effervef- cing violently when any of the ftronger acids is poured upon them. This phenomenon is owing to thefe acids difplacing, by their great affinity, the carbonic acid, which flies off in the form of a gas. The carbonates may be alfo deprived of their carbonic acid, either by the aaion of heat alone, or by heating them when mixed with charcoal, which decompofes the carbonic acid by combining with part of its oxygen, fo that both the acid and the charcoal are converted into carbonic oxide gas. The carbonates may be divided into three great families, -the alkaline, the earthy, and the metallic. Family i. The alkaline carbonates have a urinous tafte, tinge Vegetable blues green, and are foluble in water, an infoluble in alcohol. Family 2. The earthy carbonates are infipid, and infoluble in water, but foluble in water faturated with carbonic acid. Family 3. The metallic carbonates fcarcely differ in appearance from the metalic oxides. We fhall have immediately occafion to notice fome individuals of each of thefe families. CARBONASBARYTvE. (Ed.) Carbonate of baryta* Carbonated Baryta is rarely found in nature, and as it was firft difcovered by Dr. Withering, Mr. Werner gave it the name of Witherite. Its color is greyifh white, fometimes inclin- ing to milk white, and fometimes with a flight tinge of yellow, from a mixture of iron, feldom greenifh, often invefted with a red ochry cruft. It is found in folid maffes, fometimes filling an entire vein, fometimes interfperfed with fulphated baryta, frequently rounded or effeaing that form, feldom cryftallized. Texture, fibrous ; fraaure, conchoidal, fragments, long fplinters ; fpecific gravity, 4. 3 to 4. 338. Although it has no fenfible tafte, it is poi- fonous. In medicine it is only ufed for preparing the muriate of 175 Materia Medica. [Part It. baryta. It is found at Anglefarkin Lancafhire,at Alftoon moor in Cumberland, in Scotland and in Sweden, but is not common. According to different analyfes its conftituents are, Water. + 16 Acid. Baryta Withering, 20 + 86 Pelletier, 22 + 62 Kirwan, 82 + 78 Fourcroy 10 + 9° CARBONAS CALCIS. (Ed.) Creta. (Lond. Dub.) Carbonated lime. Chalk. This is the moft common in all minerals, is found under a great variety of forms, and has various names, as chalk, limeftonej marble fpar. In form it i* either amorphous, ftalaaical, orcryf- tallized. When amorphous, its texture is either foliated, flriat- ed, granular, or earthy. The primitive form of its cryftals is a rhomboidal parallelopided. Hardnefs, luftre, and tranfparancy various ; when tranfparent, it caufes double refraaion ; fpecific gravity from 2. 3 ij; to 2. 78 ; color when pure, white ; effervefces violently with muriatic acid, and diffolves entirely or nearly fo in it, forming a colorlefs folution. Its different varieties may be arranged under, 1. Soft carbonate ot lime. 2. Indurated carbonate of lime. They contain about 45 parts of carbonic acid, and 55 of lime. In medicine it is given to correa acidity in the prim ae vias, efpecially when accompanied with loofenefs Powdered chalk has been externally applied with fuccefs to fdalds and burns. In pharmacy it is employed for the preparation of carbonic acid, gas, and of the muriate of lime. CARBONAS POTASS^ IMPURUS. (Ed.) Cineres davellati. (Lond. Dub.) Pearl aflies. Potafhes. Impure carbonate of potafs. The potafhes of commerce are fent to us from the fhores ofyhe Baltic and from America. They are prepared by lixivating the afhes of vegetables in barrels, firft with cold and then with hot water, filtering the ley, and evaporating it to drynefs in an iron pot. In this ftate they ftill contain fome vegetable matter, not perfeaiy incinerated, which gives them a brown of black colon To deftroy this, and render their color purer, they are again burnt in a reverbatory furnace. They now get the name ot pearl afhes; but even yet, they are very impure, and often con- tain the fulphates of potafs and of lime, and the muriate of potafs. Theyare alio frequently adulterated with vegetable afhes, fand. Part II.] Materia Medica. 17? 772 65 5 5$ 2,54 8,57 i<54 20 2 JlQ 754 80 4 6 3°8 720 165 44 24 J99 603 152 H 79 3°4 444 148 510 34 3-04 and fulphate of potafs. The afhes are deteaed by their difficult and imperfea folution ; the fand, by the precipitation of filica in a gelatinous form by the addition of an acid, and the fulphate of potafs by its cryftallization. All vegetables which grow at a diftance from the fea afford potafhes by incineration ; herbs give the largeft proportion, then the leaves of trees, then fhrubs, and woods the leaft. It formerly had the name of Fixed Vegetable Al- kali, but it is alfo found, though much more fparingly, both irt the animal and mineral kingdoms. Vauquelin has given a table of the quantity of pure potafs, and of heterogeneous matters, contained in 1152 parts of the different potaffies of commerce. p ,- Sulphate. Muriate Infoluble Carb acid of potafs. of potafs. rcfiduum. and water. Ruffian potafhes, American do. Pearl afhes, Potafhes of Treves, Dantzig afhes, Potafhes of Vofges, 444 The potafs was eftimated by the quantity ot diluted nitrous acid faturated by it ; the fulphate of potafs by the precipitate formed with nitrate of baryta; and the muriate of potafs by that formed with nitrate of filver. All thefe different potaffies, except the laft, may be purified fufficiently for pharmaceutical purpofes, by lixiviating them with a fmall proportion of cold water, and evaporating the ley to dry- nefs in an iron pot. Carbonate of potafs is ufed in form of lotion, in rachitic and fome cutaneous difeafes, and as a ftimulant to the inaaive ftate of the veffels in certain ulcers. It is ufed internally as a diaphoretic or diuretic, and of late in calculous complaints; but its continued ufe feldom fails to injure the conftitution, or the inteftinal canal. CARBONAS SODJE IMPURUS. (Ed.) Barilla. (Lond. Dub.) Impure carbonate of foda. Barilla. Fixed mineral alkali. Soda is a very common mineral produ6tion. It is the bafis of fea fait ; and combined with carbonic acid, it is found on the fur- face of the earth in Egypt, Syria, Barbary, Hungary, &c. and is obtained by the incineration of marine vegetables, efpecially the falfola foda and kali, the fal":ornia herbacea, &c. The Span- iards even cultivate thefe in fait marffies for the fake ot the foda. Atter being cut down, they are dried like hay. A deep pit is then prepared, and a bundle or two of the dried vegetables let on fire are thrown into it. When well kindled, other bundles N 178 Materia Medina, [Part II, are thrown in until the pit is filled. When the incineration is. completed, the foda is found in the bottom, caked into a folid mafs, which is worked like a ftoney fubftance. When good, it is firm1, hard, heavy, dry, fonorous, fpongy, and internally of a blue color, mixed with white fpots, does not deliquefce, emits no Unpleafant fmell on folution, and does not leave a large propor- tion of infoluble matter. Incinerated foda is mix,ed with potafh, muriate of foda, and other faline matters ; mineral foda with clay and other earthy fubftances. The Egyptian foda was reckoned the beft; then the Spanifh (Barilla); afterwards the Carthagenian ; and that prepared from different fpecies of fuci (Kelp) is the worft. But all thefe carbonated fodas are inferior in purity to thofe now rnanufaaured in Britain, by decompofing the fulphate of jbda. That commonly ufed, is obtained by the bleachers as a refi- duum'in their method of preparing oxygenized muriatic acid, by decompofing muriate of foda with fulphuric acid and the black oxide of manganefe. The fulphate of foda is decompofed, l. By carbonate of potafs. Mr. Accum has defcribed the manipulations of this mode. A "boiling concentrated fo- lution of about 560 pounds of American potafhes is ladled into a boiling folution of 500 pounds of fulphate of foda, agitated together, and the whole 'quickly heated to ebulli- tion. It is then drawn off into leaden citterns, lined with thick ffieet leacj, and allowed to cool in a temperature which (hould not exceed §£>. The fluid is then drawn off, and the mafs of fajt wafhed with cold water, to free it from impurities, and again put into the boiler with clean water, This fecond folution is alfo evaporated at a low heat, as long as any pellicles of, fulphate of potafs form on its furface, and fall to thebot- tom of the fluid. The fire is then withdrawn, and the fluid ladled out into the ciftern to cryftallize. Unlefs the fluid be allowed to cool pretty low before it is removed to cryftallize, the fait obtained will contain fulphate of potafs. s. By acetite of lime. The acetous acid for this purpofe is obtained by diftillation from wood, during its conver- fion into charcoal. • 3. By litharge or acetite of lead. Very pure carbonate of foda is prepared by this procefs in the vicinity of Edin- burgh. 4. By decompofing the fulphuric acid by charcoal. About • ^eo cwt. of fulphate of magnefia, and 100 cwt. of char- coal are ground together, and the mixture expofed in are- Part II.] Materia Medica. 179 verbatory furnace until it becomes pafty. It is then transferred fnto large cafks and lixiviated. The ley is afterwards evaporated and cryftallized. By this or a fim- ilar procefs, very pure carbonate of foda is manutaaujred in the weft of Scotland. On the Continent, muriate of foda is fometimes decompofed by potafs, and fometimes by lime. Carbonate of foda is an article of the greateft importance in many manufaaures. In medicine it poffefes fimilar virtues with the carbonate of potafs ; and from its cryftallizability and efflorefcence when ex- pofed to the air, it is preferable to it, becaufe its dofe may be more accurately afcertained, and it may be given either in the form of powder, or made up into pills. CARBONAS Z1NCIIMPURUS. (Ed.) See Zinci Car- BONAS. CARDAMINE PRATENS1S. Petalia,folia. (Ed.) Cardamine. Flos. (Lond.) Ladies fmock. The petals and leaves. Willd. g. i*57-fip. 19. Tetradynamia Siliquofa.—Nat. ord. Siliquofx. The cardamine is a perennial plant, which grows in meadow grounds, fends forth purpliffi flowers in the fpring ; and in its fenfible qualities refembles ihefifymbrium nafiurtium. Long ago it was employed as a diuretic ; and of late it has been introduced in nervous difeafes, as epilepfy, hyfteria, choraea, afthma, &c. A drachm or two of the powder is given twice or thrice a day. It has little fenfible operation, except that it fometimes fweats. CARDAMOMUM MINUS. (Lond. Dub.) See Amo- MUM REPENS. CARDUUS BENEDICTUS. (Lond. Dub.)SecCEHT\\jre a. CARICA. (Lond. Dub.) SeeFicus. CARUM CARUI. Semen. (Ed.) Carui. Semina. (Dub.) Caruon. Semen. (Lond.) Caraway^ The feeds. Willd.g.561. fp. i. Pentandria Digynia—Nat. ord. Umbellata. Caraway is a biennial umbelliferous plant, cultivated with us, in gardens, both for culinary and medicinal ufe. The feeds have, an aromatic fmell, and warm pungent tafte. They are employed as a ftomachic and carminative in flatulent colics, and the like. P-2 / 180 Materia Medica. [Part II. CARYOPHYLLA AROMATICA. "(Dub.) Caryophyllus aroinaticus. (Ed. Lond.) See Eugenia. C ARYOPHYLLUM RUBRUM. (Lond. Dub.) See Di- ANTIIUS. CASCAR1LLA. (Lond. Dub.) See Croton. CASSIA. JVUld.g. 813. Decandria Monogynia.—Nat. ord. Lomentacea. Sp. 28. Cassia Fistula. Fruclus. (Ed.) Caffiafifiularis. Fruclus. (Lond.) Fruclus, pulpa. (Dub.) Caffia tree. The fruit. This tree is indigenous in India and Egypt, and is cultivated in Jamaica. It rifes to about thirty feet high, and has long flow- er fpikes, with yellow papilionaceous blofl'oms. Its fruit is a cylindrical pod, fcarcely an inch in diameter; a foot or more in length ; the outfide is a hard brown bark ; the in- fide is divided by thin, tranfverfe, woody plates, covered with a foft black pulp, of a fweetiffi tafle, with fome degree of acrimony. There are two forts of this drug in the ffiops ; one brought from the Eaft Indies, the other from'the Weft, (Caffia Javanica) ; the canes or pods of the latter are generally large, rough, thick rinded, and the pulp naufedus ; thofe of the former are lefs, fmoother, the pulp blacker, and of a fweeter tafte ; this fort is preferred to the other. Such pods ffiould be chofen as are weighty, new, and do not make a rattiing noife (from the feeds being loofe within them) when ffiaken. The pulp ffiould be of a bright, fhining, black color, and have a fweet tafte, neither harfh, wJmcIi happens from the fruit being gathered before it has grown fully ripe, norfour- iffi, which it is apt to become upon keeping, nor at all mouldy, which from its being kept in damp cellars, or moiftened in order to increafe its weight, it is very fubjea to be. Greateft part of the pulp diffolves both in water and in reaified fpirit ; and may be extraaed from the pod by either. The (hops employ water, boiling the bruifed pod therein, and afterwards evaporating the folution to a due confiftence. The pulp of caffia, from its faccharine and mucilaginous confti- tuents, is a gentle laxative medicine, and frequently given, in a dofe of fome drachms, in coftive habits. Some direct a dofe of two ounces or more as a cathartic, in inflammatory cafes, where the more acrid purgatives have noplace ; but in thefe largequan- tities it generally excites naufea, produces flatulencies, and fome. limes gripings of the bowels, efpecially if the caffia be not of a very good kind ; thefe effeas may be prevented by the addition of aromaties, and by exhibiting it in a liquid form. Part II.] Materia Ml died. m Sp. 24. Cassia Senna. Folia. (Ed.) Senna. Folia. (Lond. Dub.) Senna. The leaves. « This fpecies of caffia is annual, although in its mode of growth it refembles a fhrub, and fends out hollow, woodv items'to the height of four feet. It grows principally in Upper Egypt, from whence the leaves are brought, dried and picked from the ftalks, to Alexandria in Egypt, and thence imported into Europe. They are of an oblong figure, (harp pointed at the ends, about a quarter of an inch broad, and not a full inch in length, of a lively yellow iffi green color, a faint, not very difagreeable fmell, and a fubacrid, bitteriffi, naufeous tafte. Some inferior forts are brought from other places; thefe may eafily be diftinguifhed by their being either narrower, longer, and (harper pointed, from Mocha ; or larger, broader, and round pointed, with fmall promi- nent veins, from Italy ; or large and obtufe, of a frefh green col- or, without any yellow caft, from Tripoli. ft has been cuttomary to rejeft the pedicles of the leaves of fenna as caufing gripes and pains in the boweh>; but this is a mere prejudice, for both leaves and pedicles aa in the very fame way. Senna is a very ufeful cathartic, operating mildly, and yet ef- fe£lually ; and, if judicioufly dofed and managed, rarely occafion- ing the ill confequences which too frequently follow the exhibi- tion of the ftronger purges. The only inconveniences complain- ed of in this drug are, its being apt to gripe, and its naufeous fla- vor. Thefe are beft obviated by adding to the fenna fome aromatic fubftance, as ginger, .cinnamon, &c. and by facilitating its opera- tion by drinking plentifully of any mild diluent. Senna may be given in fubftance to the extent of about a drachm, but it is rather too bulky, and it is therefore better to divide it into two dofes, and to take the one half at night and the other in the morning. It is more conveniently given in the form of infufion, which is generally made by pouring about fix ounces of boiling water upon from two to fix drachms of fenna leaves in a tea pot, and letting it ftand about an hour. Senna ought never to be ordered in deco6tion, Amemann fays, becaufe it always gripesfeverely, from too many refinous particles being diffolved; Gren fays, becaufe it becomes perfeaiy inert from the total difli- pation of the naufeous and volatile principle on which its purga- tive and griping effeas depend. The tinaure on account of the menftruum, cannot be given in dofes large enough to purge. CASTOR FIBER. Materia infollicuiis prope aturn collecla. (Ed.) Cafloreum Rofficum. (Dub.) Materia in fclhculoprope anum fito collecla. (Lond.) 3 1&2 Materia Medica. [Part II. The Beaver, Caftor. The fubftance colleaed in the follicles near the anus.—Mammalia rodentia, Cuvier. The beaver is ftrongly charaaerized by its flat horizontal, fcaly tail. It is an amphibious animal, and is found in the nor- thern parts of Europe, Afia and America, on the banks of lakes and rivers. In inhabited countries it is a folitary flothful animal but in the defert regions it lives in fociety ; the remarkable man- ners of which, and the immenfe works effeaed by the united la- bors of all the individuals of their republic, have rendered the natural hiftory of this animal familiar to every one. In both fexes, between the anus and pudendum, there are four follicles of an oblong fhape, fmailer above and larger below, formed of a tough membrane, almoft refembling leather. The two largeft and undermoft of thefe, which are alfo conneaed, and lie parallel and clofe to each other, contain an oily fluid fecretion, which is the fubftance known by the name ot caftor. It is preferved by cutting out the entire bags, and drying them in the fmoke. The beft caftor comes from Ruffia, Pruffia and Poland. The cods fhould be dry; gibbous, roundifh, heavy, folid, and filled with a folid fubftance, contained in membranous cells, fomewhat tough but brittle, of a dark brown color, of a- peculiar difagreeable^ narcotic fmell, and a naufeous bitter acrid tafte. The Canadian ' caftor is of an inferior quality ; the cod* are fmaller, thin, oblong and much corrugated, and the caftor itfelf has much lefs fmell and tafte.; What is very old, quite black, and almoft deftitute of fmell and tafte is unfit for ufe, as well as the counterfeited caftor, which is a mixture of various gummy refins and other fubftances, with a little real caftor,. artificially interfperfed with membranes, and fluffed into the fcrotum of a goat. ;This impofition is eafily de- teaed by the weaker degree of its fmell and tafte, by chemical analyfis, and even by mere external examination ; for to the real bags, the two fmaller and upper follicles, filled with a fatty mat- ter, are always attached. The predominant or really aaive conftituent of caftor, is of a volatile nature, though not properly an effential oil. Water dif- tilled from it fmells ftrongly ot caftor, and has an aromatic tafte, but does not afford any effential oil, and the refiduum ftill pre- ferves a ftrong fmell and tafte ot caftor. Water extraas from it about o.io of a gelatine, and alcohol 0.2,5 of refin. The refiduum now confifts ot fibrous matters. To preferve caftor, it ffiould be kept wrapt up is bladder or oiled paper. Caftor is an excellent antifpafmodic. It is very little heating, and aas particularly upon the uterine fyftem. It is given with advantage, 1. In typhoid fevers. 2. In fpafmodic difeafes, efpecially in hyfteria and epilepfy, and in cafes of difficult parturition, from a fpafmodic con- Part II.] Materia Medica. 186 traaion of the mouth of the uterus after the membranes have burft. 3. In amenorrhcea. It is exhibited moft advantageoufly in the form of powder, in dofes of from 10 to 20 grains, and in clyfters to a drachm. Di- luted alcohol extraas its virtues ; therefore it may be alfo given in the form of tiaaure. But its exhibition in the form of extra& or decoaion is improper. CATECHU. (Lond. Dub.) See Mimosa. CENTAUREA BENEDfCTA. Herba. (Ed.) Carduus Benediclus, Herba. (Lond.) Folia. (Dub.) Bleffed Thiftle. The leaves or plant. Syngenefia Polygamiafrufiranea.—Nat. ord. Compofitacapitata* This is an annual plant, indigenous in the Grecian iflands,and cultivated in gardens ; it flowers in June and July, and perfeas its feeds in the autumn. The herb (hould be gathered when in flower, quickly dried, and kept in a very dry airy place, to pre- vent its rotting or growing mouldy, which it is very apt to do. The leaves have a penetrating bitter tafte, not very ftrong or very durable, accompanied with an ungrateful flavor, from which they are in a great meafure freed by keeping. Water extraas, in a little time, even without heat, the lighter and more grateful parts of this plant ; if the digeftion be continued for fome hours, the difagreeable parts are taken up. A ftrong decoaion is very nau- feous and offenfive to the ftomach. Reaified fpirit gains a very pleafant bitter tafte, which remains uninjured in the extraa* The virtues of this plant feem to be little known in the prefent praaice. The naufeous decoaion is fometimes ufed to provoke vomiting ; and a ftrong infufion to promote the operation of other emetics. But this elegant bitter, when freed from the offenfiTe parts of the herb, may be advantageoufly applied to other purpo- fes. We have frequently experienced excellent effeas from a flight infufion of carduus in lofs of appetite, where the ftomach was injured by irregularities. A ftronger infufion made in cold or warm water, if drunk freely, and the patient kept warm, occa- fions a plentiful fweat, and promotes the (ecretions in general. The extraa prepared, by evaporating the expreffed juice, with the addition of a little alcohol to prevent it from becoming moul- dy, has been ftrongly recommended in the catarrh of children; The feeds of this plant are alfo confiderably bitter, and have been fometimes ufed with the fame intention as the leaves. CENTAUREUM MINUS. (Lond. Dub.) See Chironia Centaureum. fct-4 184 Materia Medica. CEPA. (Dub.) SeeALLiUM Cepa. CEPHAELIS IPECACUANHA. Ipecacuanha. Radix. (Lond. Ed. Dub.) Ipecacuan. The root. Willd. g. S57-JPec^es nova-—Pentandria Monogynia—Nat. ord. Aggregate. This plant is perennial, and grows in Brazil in moift woody fituations. Notwithftanding the root has been fo long in general ufe, the plant to which it belonged was not fatisfaaorily afcertain- ed until very lately, when a complete monography of it, and an excellent plate were publiffied in the fixth volume of the Tranf- aftions of the Linnsean Society, by Profeffor Brotero, who calls it the Callicocca Ipecacuanha ; but the genus Caliicocca has been united by Willdenow with that of Cephaelis, to which we have therefore referred it. The plate of Brotero correfponds with that publiffied in Wood- vilte's Medical Botanv, vol. 3, from a plant fent in fpirits from Brazil by Governor Philips to Sir Jofeph Banks, but which un- fortunately was not in flower, and alfo with the rude draught of Pi- fo, who firft examined it. It likewife agrees in many effential charaaers, though not in all, with the defcription given of the Pfychotria Emetica of Dr. Mutis. Indeed, the genera of Pfy- chotria and Cephaelis are not fufficiently diftinguifhed. The root is brought from Spanifh America. It is divided into two forts, Peruvian and Brazilian; but the eyediftinguiffies three, afh colored orgrey, brown and white. The afh colored, or Peruvi- an ipecacuan of the ffiops, is a fmall wrinkled root, bent and con- torted into a great variety of figures, brought over in fhort pieces full of wrinkles, and deep circular fiffures, quite down to a fmall , white woody fibre that runs in the middle of each piece ; the cor- tical part is compaa, brittle, looks fmooth and refinous upon breaking; it has very little fmell; the tafte is bitteriffi and fub- acrid, covering the tongue as it were with a kind of mucilage. The brown ipecacuan is fmall, and fomewhat more wrinkled than the foregoing ; its bark is of a brown or blackiffi color without, and white within j this is brought from Brazil, and is the root of the cephaelis. The white fort is woody, has no wrinkles, and no perceptible bitternefs in tafte. It is probably the root of a viola. The firft fort, the afh colored or grey ipecacuan, is that ufually preferred for medicinal ufe. The brown has been fometimes ob- ferved, even in a fmall dofe, to produce violent effeas. The white, though taken in a large one, has fcarce any affe& at all. Ipecacuan was firft brought into Europe about the middle of laft century, and an account of it publiffied about the fame time by Pifo; but it did not come into general ufe till about the year 1686, when Helvetius, under the patronage of Lewis XIV, in- [Part II Part II.] Materia Medica. 185 troduced it into praaice. This root is one of the mildeft and fafeft emetics with which we are acquainted, and has this peculiar ad- avantage, that when it does not operate by vomiting, it paffes off by o her emunaories. Many ingenious experiments were made on the fubjea of ipe- cacuan by Dr. Irvine, for which he obtained the prize medal of the Harveian Society at Edinburgh in 1784. He afcertained that this root contains a gummy refinous matter ; that the gummy exifts in a much greater proportion than the refinous part ; that the gummy part is much more powerfully emetic than the refi- nous ; that the cortical is more aaive than the ligneous part ; and that the whole root poffeffes confiderable influence, both as an an- tifeptic and aftringent; that the diftilled water has very little in- fluence ; but that the decoaion which remained in the ftill, ope- rated violently as an emetic, produced rigors, cold fweats, and other alarming fymptoms ; that by long continued boiling, the aaivity of the root is almoft totally dgftroyed ; that the emetic property of ipecacuan was moft effeaually counteraaed by means of the acetous acid, infomuch that thirty grains of the powder ta- ken in two ounces of vinegar, produced only fome loofe (tools. From thefe experiments it evidently appears, that the a&ive conftituents of ipecacuan are a fpecies of extraaive and a refin, and that its emetic property depends upon the former. Others have found, that the latter or refinous part is more apt to aa upon the inteftinal canal, and to operate by (tool. The primary effea of ipecacuan is that of ftimulating the fto- mach. If the dofe be fufficiently large, it excites vomiting, by inverting the periftaltic motion of the ftomach and duodenum ; in a fmaller dofe, it only produces naufea, and operates by ftool; and in ftill fmaller dofes, it gently ftimulates the ftomach, increafesthe appetite, and facilitates digeftion. Its fecondary effeas depend on the fympathy of other parts with the ftomach ; and in this way only can we explain its aaion as an antifpafmodic, diaphoretic, ex- pectorant, and in checking hasmorrhagies. Its beneficial effeas in fome cafes alfo feem to be owing to the general concuffion given to the whole fyftem during the aaion of vomiting. Ipecacuan, properly adminiftered, often proves ferviceable, 1. In intermittent fevers. It has frequently fucceeded in flopping thefe, when given about an hour before an accef- fion was expedted, and alfo when given fo as to produce vomiting at the time of an acceffion, or at the end of the cold ftage. 2. In continued fevers. We have never feen more decided- ly beneficial effeas from the ufe of any medicine w hat- ever, than from the exhibition of ipecacuan in the'com- mencement of typhus fever. An emetic, fucceeded by a -* diaphoretic regimen, when adminiftered fufficiently early 186 Materia Medica. [Part. II. in this difeafe, very frequently cuts it fhort at once, and when it fails in this defirable objea, it always has a bene- ficial influence on the progrefs of the fever. 3. In inflammatory difeafes, rheumatifm, bubo, fwelled tef- ticle. 4. In exanthematous difeafes, when the eruption is difpofed to recede. 5. In haemorrhagies, when given in naufeating dofes. 6. In profluvia, efpecially in dyfentery, fo much fo, that it was formerly efteemed a fpecific againft that difeafe. But Cnllen attributes its good effeas in this inftance, to its producing a fteady determination of the periftaltic motion of the inteftines downwards, when given in repeated fmall dofes. 7. In many fpafmodic difeafes ; in epilepfy ; afthma ; dyf- pncea ; pertuffis; 'chronic diarrhoea ; hyfteria ; melaneho* lia; mania. .8. In cacheaic difeafes, as in fome kinds of dropfy* 9. In impetiginous difeafes ; in jaundice; 10. In local difeafes ; in amaurofis, and feveral of the dyfoi rexias. 11. Laftly, in every inftance when we wiffi to evacuate the ftomach, as when it is overloaded with food, or when poi- fon, efpecially opium, has been fwallowed. The ufe of ipecacuan, as an emetic, is contra indicated, *. Where there is a difpofition to haemorrhagy. 2. Where there is an increafed flow of blood towards the* head. 3. In very irritable fubjea.s. 4. In pregnant women, and perfons affliaed with hernia*. Ipecacuan is exhibited, i. In fubftance ; in powder. Full vomiting will generally be produced in an adult by a fcruple or half a drachm, and though lefs might anfwer the purpofe, fortunately an over dofe is fcarcely attended with any inconvenience, as the whole of it is vomited with the contents ot the ftomach as foon as it operates. The vomiting is promoted and fa- cilitated by drinking copioufly of warm watery fluids. On the contrary when vomiting is not intended, liquids muft be rather drunk fparingly, and the dofe muft be diminifh- ed to a grain or lefs. In fuch fmall dofes it is convenient- ly combined with any proper adjuna, in the form of pow- der, pill or bolus. 2. In infufion. One drachm may be infufed in four ounc- es of water, and taken in repeated dofes till it operate. 3. Infufed in wine. See Vinum IfecacuanhvE. Part II.] Materia Mediial 187 Ipecacuan not only checks the narcotic effeas of opium, and is therefore one of the beft antidotes for its poifon, but reciprocally the emetic powers of ipecacuan are checked by the addition of opium, and the combination operates by increafing the cuticular difcharge. See Pulvis Ipecacuanha et Opii. CERA FLAVA. (Ed. Lond. Dub.) Yellow wax. For this ufeful fubftance we are indebted to the common honey bee, (apis mellifica) an infea belonging to the clafs of i/y- menoplera mellita of Cuvier. It is however, a vegetable produc- tion, and is colleaed by the bees from the furface of leaves, and the antherae of flowers. They employ it to form the combs in which the honey and larvae are depofited. It is found in the ffiops in round cakes, which are formed by melting the combs, after all the honey has been expreffed from them, in hot water. The wax fwims above, and the impurities either fink to the bottom, or are diffolved in the water. When recent, it is tenacious, but brittle, of a yellow color, and fweet honey like fmell; dry, not greafy, to the feel; infoluble in water, alcohol and ether; foluble in the fatoils and alkalies; fufible and inflammable. In fekaing it, we ffiould obferve that the cakes be brittle, have a pleafant yellow color, an agreeable fmell.no tafte, do not adhere to the teeth when chewed, and burn entirely away. When adulterated with refin, the fraud is deteaed by its tafte, and the aaion ©f alcohol, which diffolves the refin. When mixed with peafe meal or earthy fubftances, it is more brittle, of a paler color, and may be feparated from them by liquefaaion and (training. When combined with tallow, it becomes lefs brit- tle, but at the fame time fofter, and has an unpleafant fmell. CERA ALBA. (Lond. Dub. Ed.) White wax. The yellow color of bees wax, and its peculiar fmell, may be deftroyed by the combined aaion of water, air, and the fun's rays. In the procefs for bleaching wax, we, therefore, extend its furface as much as poffible, by melting it and forming it into thin plates, which are fully expofed to the fun's rays, upoa linen ftretched in frames, and repeatedly moiftened, until they acquire the whitenefs defired. It is then ufually melted into thin difes. White wax is more brittle, lefs fufible, and heavier than yellow wax. It is fometimes mixed with white oxide of lead, or with tallow. For medical ufe, it has no advantage over yellow wax. When taken internally, wax agrees in its effects with the fat oils, and though lefs frequently prefcribed in this way, it is pre- ferable, in being lefs apt to become rancid. Poerner recommends it as an excellent remedy in difeafes of the inteftines, attended 18.8 Materia Medica. [Part II. with pain, excoriation, and obftinate diarrhoea. He gave a fcruple or half a drachm of wax, three or four times a day, in the form of an emulfion, by melting it firft with fome fixed oil, and then mix- ing it with a decoaion of groats by trituration with the yolk of an egg. But by far its principal ufe is for the formation of ce- rates, ointments, platters, &c. CERUSSA. SeePLUMBl OXIDUM ALBUM. CERVUS ELAPHUS. Cornu. (Ed.) Cornu Cervinum. (Dub.) Cervus. Cornu. (Lond.) The flag or hart. The horns. This animal belongs to the clafs mammalia, order ru?ninantia: The male has two round folid horns on his forehead, with feveral conical branches, the number of which afcertain the age of the animal to which they belong. Thefe horns fall off and are renew- ed every year. When firft reproduced, they are foft, full of blood veffels, and covered with a velvety fkin, but they foon lofe their covering, and become hard, compaa, and bony. In their nature, they do not feem to differ from bone except in containing a larger proportion of cartilage. They afford a very confiderable quantity of gelatine by decoaion with water, and hartffiorn ffiavings are ftill employed in domeftic economy for furnifhing a nutritious and demulcent jelly. By the aaion of fire their proauas are the fame with thofe ot animal fubftances in gen- eral, and they were formerly fo much ufed for the preparation of ammonia, that it was commonly called Hartffiorn. By burn- ing they are totally converted into phofphate of lime. CHAMvEMELUM. (Lond. Dub.) SeeANTHEMis. CHIRONIA CENTAUREUM. Gentiana Centaureum. Summitatesfiorentes. (Ed.) Centaureum minus. Summitatesfiorentes.(Dub.) Cacumen.(Lond.) Smaller Centaury. The flowering heads. Willd. g. 394. fp. 9. Pentandria Monogynia—Nat ord. RotaCea. This plant is annual and grows wild in many parts of England on barren paftures. It flowers between June and Auguft. The corolla is faid to have no tafte ; and therefore the herb, which is intenfely bitter, ffiould be preferred to the flowering tops, which derive their virtues only from the ftalks conneaed with them. It agrees in every refpea with other pure bitters. CICUTA. (Lond. Dub.) SeeCoNiUM. C1NARA. (Lond. Dub. Ed.) SeeCYNARA. Part II.] Materia Medica. 189 CINCHONA. Willd. g. 346. Pentandria Monogynia.—Nat ord. Contdrta. Sp. 1. Cinchona officinalis. Cortex. (Ed.)' Cinchona. Cortex. (Lond.) Cortex Peruvianus. (Dub.) Officinal Cinchona. The bark, commonly called Peruvian bark, of which the Edinburgh College enumerates three varieties, a. The common, b. The yellow, c. The red. It is, however, by no means afcertained, that the two laft are the bark ot the cinchona officinalis, but have been merely claffed un- der it until we are better acquainted with their botanical hiftory. The cinchona officinalis grows in the neighborhood of Loxa, a city in the province of Quito, in the kingdom of Peru. It is a mountainous tree, and is- never found in the plains. It grows to a great height, and formerly its trunk was often thicker than a man's body. But fince its bark has come into fuch general ufe, few trees are to be feen thicker than a man's arm. Indeed, there is reafon to fear that it will become ftill more fcarce, as no atten- tion is paid to its cultivation, and the trees always die after being ftripped of their bark. This operation is performed in the dry feafon, from September to November. The bark is then care- fully dried in the fun, and packed in fkins, which contain from 100 to 150 pounds, and are called by the Spaniards zeronne. In thefe coarfe and fine pieces of the fame kind of bark are promif. cuoufly mixed, but they are afterwards forted. 1. Common pale bark. In commerce we find feveral varieties of the common pale bark, the moft remarkable of which come from Loxa, the quilled bark, and from Guanaco, the flat bark. The bark which comes from Loxa confifts of thin finglyor doubly rolled pieces a finger's length or more, and fcarcely a line in thicknefs ; externally rough, of a greyifh brown color, and generally covered with a kind of lichen ; internally of a cinna- mon color. Its fraaure ffiould not be fibrous or powderv, but e- ven and ffiining. It has a peculiar aromatic fmell, and a pleafant bitter aftringent tafte. The bark which comes from Guanaco confifts of much thicker, coarfer, and flatter pieces ; externally of a dark brown or almoft black color, but internally it has the fame cinnamon color, and in its refinous fraaure, fmell, and tafte, it exaaiy refembles the former. When genuine, both varieties are excellent remedies, although the former be generally preferred on the Continent, and the latter in Britain. The great price of Peruvian bark has fometimes tempted dif- heneft men to adulterate it with other fimilar and lefs powerful 190 Materia Medica. [Part II, barks, and, what is ftill more blameable, with genuine bark, frqm which the aaive conftituents have been entirely extraaed by de- coaion with water. In feleaing Peruvian bark, we muft therefore fee, that, befides the charaaeriflics already noticed, it be denfe, heavy, and dry, not mufty or fpoiled by moifture, and that a decoaion made of it have a reddifh color when warm, but when cold become paler, and depofite a brownifh red fediment. Thofe pieces whofe tafte is fimply intenfely bitter or very aftringent, or naufeous, or merely mucilaginous, whofe furface is fmooth or polifhed of a dark color or pale yellow or red, which are tough or fpongy, whofe fraaure is fibrous, woody, or powdery, and their internal color, white or grey, are to berejeaed. The predominant conftituents of Peruvian bark are, bitter, ex- traaive, tannin and gallic acid, combined with fome mucilage and refin. Its aroma depends upon the prefence of fome effen- tial oil, which, however, is not confiderable. On dead animal matter it acts as an antifeptic, and on the living body it aas moreover as a ftimulant, tonic, and antifpafmodic—~ The difcovery of its medical virtues was, in all probability, the refult of accident ; and in faa, according to fome, the Peru- vians learned the ufe of the bark by obferving certain animals affeaed with intermittents inftinaively led to it ; while others fay, that a Peruvian having, an ague, was cured by happening to drink of a pool which, from fome trees having fallen into it, tafted of cinchona ; and its ufe in gangrene is faid to have originated from its curing one in an aguifh patient. About the year 1640, the lady of the Spanifh viceroy, the Comitiffa del Cinchon, was cured by the bark, which has therefore been called Cortex or Pul- vis Comitiffas, Cinchona, Chinachina or Cinchina, Kinakina or Kinkina, Quinaquina or Quinquina ; and from the intereft which Cardinal de Lugo and the Jefuit fathers took in its diftribution, it has been called Cortex or Pulvis Cardinalis de Lugo, Jefuiticus, Patrum, &c. or fimply from its preeminence, Bark. On its firft introduction into Europe, it was reprobated by ma- ny eminent phyficians ; and at different periods long after, it was confidered a dangerous remedy ; but its charaaer, in procefs of time, became very univerfally eftablifhed. Praaitioners have differed much with regard to the mode of operation of the Peruvian bark. Some have afcribed its virtues entirely to a ftimulant power. But while the ftrongeftand moft permanent ftimuli have by no means the fame effea with bark in the cure of difeafes, the bark itfelt fhows hardly any ftimulant power, either from its aaion on the ftomach, or on other fenfible parts to which it is applied. From its aaion on dead animal fi- bres, there can he no doubt of its being a powerful aftringent j and from its good effeas in certain cafes ot difeafe, there is reafoa Part II.] Materia Medica. 191 to prefume that it is a ftill more powerful tonic. Tq this tonic power fome think that its aaion as an antifeptic is to be entirely attributed ; but that, independently of this, it has a very power- ful effea in refitting the feptic prqgrefs to which animal fubftan- ces are naturally fubjeaed, appears beyond all difpute, from its effeas in refitting putrefaaio», not only in dead animal folids, but even in animal fluids, when entirely detached from the living body. But although it be admitted that the Peruvian bark aas power- fully as an aftringent, as a tonic, and as an antifeptic, yet thefe principles will by no means explain all the effeas derived from it in the cure of difeafes. And accordingly, from no artificial com- bination in which thefe powers are combined., or in which they exift even to higher degree, can the good confequences refulting from Peruvian bark be obtained. Many praaitioners, therefore, are difpofed to view it as a fpecific. l-i by a fpecific we mean an infallible remedy, it cannot indeed be confidered as entitled to that appellation ; but in as far as it is a very powerful remedy, of the operation of which no fatisfaaory explanation has yet been given, it may with great propriety be denominated a fpecific.— But whatever its mode of operation may be, there can be no doubt that it is daily employed with fuccefs in a great variety of different difeafes. It was firft introduced, as has already been faid, for the cure of intermittent fevers; and in thefe, when properly exhibited, it rarely fails of fuccefs. Praaitioners, however, have differed with regard to the beft mode of exhibition ; fome prefer giving it juft before the fit, fome during the fit, others immediately after it. Some, again, order it in the quantity of an ounce between the fits ; the dofe being the more frequent and larger according to the frequency of the fits ; and this mode of exhibition, although it may perhaps fometimes lead to the employment ol more bark than is neceffary, we confider as upon the whole preferable, from being beft fuited to moft ftomachs. The requifite quantity is ve- ry different in different cafes; and in many vernal intermittents it feems even hardly neceffary. It is now given, from the very commencement of the difeafe, without previous evacuations, which, with the delay of the bark, or under dofes of it, by retarding the cure, often feem to induce abdominal inflammations, fcirrhus, jaundice, heaic, dropfy, &c. fymptoms formerly imputed to the premature or intemperate ufe of the bark, but which are beft obviated by its early and liberal ufe. It is to be continued not only till the- paroxyfms ceafe, but till the natural appetite, ftrength and complexion return. Its ufe is then to be gradually left off, and repeated at proper intervals to fecure againft arelapfe; to which, however, unaccountable,there 192 Materia Medica. [Part II, often feems to be a peculiar difpofition ; and efpecially when the wind blows from the eaft. Although, however, moft evacuants conjoined with the Peruvian bark in intermittents are rather pre- judicial than otherwife, yet it is of advantage, previous to its ufe, to empty the alimentary canal, particularly the ftomach ; and on this account good affecls are often obtained from premifing an emetic. It is a medicine which feems not only fuited to both formed and latent intermittents, but to that ftate of fibre, on which all ri- gidly periodical difeafes feem to depend ; as periodical pain, in- flammation, hacrnorrhagy, fpafm, cough, lofs of external fenfe, &c. Bark is now ufed by fome in all continued fevers; at the fame time attention is paid to keep the bowels clean, and to promote when neceffary the evacuation of redundant bile, always, how- ever, fo as to weaken the patient as little as poffible. In confluent fmall pox, it promotes languid eruption and fup- puration, diminifhes the fever through the whole courfe of it, and prevents or correas pretefcence and gangrene. In gangrenous fore throats it is much ufed, as it is externally and internally in every fpecies of gangrene. In contagious dyfentery, after due evacuation, it has been ufed, taken internally and by injeaion, with and without opium. In all thofe hasmorrhagies called paffive, and which it is allow- ed all basmorrhagies are very apt to become, and likewife in other increafed difcharges, it is much ufed ; and in certain undefined cafes of haemoptyfis, fome allege that it is remarkably effectual whenjoined with an abforbent. It is ufed for obviating the difpofition to nervous and convul- five difeafes; and fome have great, confidence in it, joined with fulphuric acid, in cafes of phthifis, fcrofula, ill conditioned ulcers rickets, fcurvy, and in ftates of convalefcence. In thefe cafes, notwithftanding the ufe of the acid, it is proper to conjoin it with a milk diet. In dropfy, not depending on any particular local affeaion.itis often alternated or conjoined with diuretics or other evacuants, and by its early exhibition after the water is once drawn off, or even begins to be freely difcharged, a frefh accumulation is pre- vented, and a radical cure obtained. Mr. Pearfon of the Lock Hofpital praifesvery highly the pow- ers of this remedy in different forms of the venereal difeafe ; in reducing incipient bubo, in cleanfing and healing ulcers of the tonfils, and in curing gangrenous ulcers from a venereal caufe. But in all thefe cafes mercury muft aifo be given to eradicate the ve. neieal virus trom the fyftem. Peruvian bark may be exhibited, i. In fubftance. rart. II.] Materia Medica. 193 The beft form of exhibiting this valuable remedy is in the ftate of a very fine powder, in dofes of from ten grains to two drachms and upwards. As it cannot be fwallowed in the form of a dry powder, it muft either be diffufed in fome liquid, as water, wine, or milk, or mixed with fome vifcid fubftance, as currant jelly. Its tafte, which is difagreeable to many people, is beft avoided by taking it immediately after it is mixed up ; for by ftanding any time, it is communicated to the vehicle. In this re- fpea, therefore, it is better for the patients to mix it up them- felves than to receive it from the apothecary already made up into a draught with fome fimple diftilled water, or into an eleau- ary with a fyrup. A much more important objeaion to this form of giving Peruvian bark is, that fome ftomachs will not bear it, from the oppreffion and even vomiting which in thefe cafes it ex- cites. We muft endeavor to obviate this inconvenience by the addition of fome aromatic, and by giving it in fmall dofes more frequently repeated. If we are unable to fucceed by thefe means, we muft extraa the moft aaive conftituents of the bark by means of fome menftruum. It has therefore long been a pharmaceutical problem to difcover which menftruum extraas the virtues of Pe- ruvian bark moft completely. But the aaive conftituents of this remedy, according to the beft and lateftanalyfis, are bitter extraa- ive, tannin, and gallic acid, combined with fome mucilage and re- fin. Of thefe the two laft are not foluble in any one menftruum; but they moft probably contribute very little to the powers of the medicine. The three other conftituents, on the contrary, on which all its aaivity depends, taken fingly, are all of them very foluble, both in water and in alcohol, and in every mixture of thefe. But it would be contrary to analogy to fuppofe, that thefe fubftances fhould exift fo intimately mixed as they muft be in an organic bo- dy, without exerting upon each other forae degree of chemical af- finity, and forming combinations poffeffed of new properties. Ac- cordingly we find, whether it arife from this caufe, or merely from the ftate of aggregation, that neither'water nor alcohol ex- traa thefe conftituents from Peruvian bark in the fame quantity in which they are able to diffolve them feparately, and that we muft have recourfe to direa experiment to determine the degree of aaion poffeffed by each menftruum upon it. With this view many experiments have been made, and by very able chemifts. But molt of them were performed when the fcience of chemiftry wis but in its infancy; and even at this time that branch of it which relates to thefe fubftancesis fo little undcrPood, thut the re- fill ts of the late experiments are far from conclufive. 2. In infufion. To thofe whofe ftomachs will not bear the powdv ■'. '. is the beft form of exhibiting Peruvian bark. Water, at ? given :_mper- ature feems capable of diffolving only a certain quantity, and 194 Materia Medica. [Part II. therefore we are not able to increafe the ftrength of an infufion, either by employing a larger quantity of the bark, or allowing them to remain longer in contaa. One part of bark is fufficient to faturate fixteen of water in the courfe ot an hour or two. To ac-. celerate the action of the water, it is ufual to pour it boiling hot upon the bark, to cover it up, and allow it to cool flowly. After fianding a fufficient length of time, the infufion is decanted off for ufe. The infufion in water is however liable to one very great objeftion, that it cannot be kept even a very ffiort time without being decompofed and fpoiled. Therefore, in fome inftances, we prepare the infufion with wine ; and it. fortunately happens that very often the ufe of the menftruum is as much indicated as that of the folvend. 3. In tincture. The great aaivity of the menftruum in this preparation, pre- vents the bark from being given in fufficiently large dofes to exert its peculiar virtues. It is however, a powerful ftimulant. 4. In decoction. Water of the temperature of 2120 is capable of diffolving a much larger proportion of the foluble parts of Peruvian bark than water at 6o©. But the folvent powers even of boiling water have their limits> and by protraaing the decoaion we do not increafe its ftrength, but rather, by diminiffiing the quantity of the men- ftruum, we leffen the quantity of matter diffolved. Befides, at a boiling temperature, extraaive abfords oxygen rapidly from the atmofphere, and is converted into what feems to be an infoluble and inert refinous fubftance. 5. In extraa. In this preparation we expea to poffefs the virtues of Peruvian bark in a very concentrated ftate. The principal objeaions to its ufe are its great expenfe, and the decompofition and deftruaion of the aaive conftituents of the bark during the preparation, when not properly conduaed. It is convenient for the formation of pills and bolufes, but we would always prefer a frefh infufion or decoaion to any mixture in which the extraa is rediffolved. Externally, Peruvian bark is ufed in fubftance, as an applica- tion to ill conditioned, carious, or gangrenous ulcers. In the form of clyfter, it may be given in fubftance, decoaion or extraa. The powder is ufed as a tooth powder for fpongy and bleeding gums, and the decoaion is an excellent aftringent gargle or wafh. - To increafe the power of Peruvian bark, or to direa its effica- cy to a particular purpofe, or to correa fome inconveniences oc- cafionally produced by it, it is frequently combined with other remedies. When it produces vomiting, carbonic acid forms a ufeful addition ; when it purges, opium ; when it oppreffes the ftomach, aromatics ; and when it induces coftivenefs, rhubarb. It may be alfo combined with other vegetable aftringent or bit- ter remedies, without impairing its powers. But we are a- Part II] Materia Medica-. 195 fraid that many additions are made, chiefly faline fubftances, of which the effeas are not at all underftood. Sulphuric acid, fuperfulphate of alumina and potafs (alum) muriate of ammonia, carbonate of potafs, tartrite of potafs, tartrite of antimony and potafs (tartar emetic) iron, lime water, &c. have been frequently prefcribed with it ; but we know that in many of thefe mixtures decornpofition occurs, which renders the whole either inaaive, er completely deceives us with regard to the expeaed effeas. 2. Yellow Peruvian bark. This kind of bark has only been introduced fince 1790, and we are ftill uncertain, both with regard to the tree which pro- duces it, and the place of its growth. It confifts of pieces a- bout fix inches in length, thicker, and lefs rolled up than the common bark. Its internal furface is of a deeper red. It fome- times wants the epidermis, which is often as thick as the bark it- felf. It is lighter and more friable than the former variety ; its fraaure is fibrous ; and when reduced to powder, its color is paler. Its tafte is much more bitter, aftringent, and ftronger, but its fmell is weaker. Its decoaion when hot is redder, but when cold, paler. Its folutions ftrike a deeper color with fulphate of iron. It contains more bitter extraaive, and more tannin and gallic acid, than either of the others, but lefs gum than the com- mon, and lefs refin than the red. It alfo produces the fame ef- feas in much fmaller dofes. The epidermis fhould always be removed before it is powdered. 3. Red Peruvian bark occurs generally in much larger, thick- er, flatter pieces, but fometimes alfo in the form of quills. It is heavy, firm, found and dry ; friable between the teeth ; does not feparate into fibres ; and breaks not fhivery, but ffiort, clofe and fmooth. It has three layers ; the outer is thin, rugged, of a red- difh brown color, but frequently covered with moffy mat,ter ; the middle is thicker, more compaa, darker colored, very refin- ous, brittle, and yields firft to the peftle ; the inmoft is more woody, fibrous, and of a brighter red. Its powder is reddifh, like that of Armenian bole. Its aftringency and bitfernefs are more intenfe, and it contains more refin than the pale bark. It alfo produces its effeas in fmaller dofes. It is faid to be mdre frequently adulterated. 4. Cinchona CaribjEA. Cortex. (Ed.) Cinchona of the Caribaean iflands. The bark. This tree is found in the Caribbean iflands. It grows to a very large fize. Dr. Wright, to whom we are indebted for all our knowledge of it, found fome in the pariffi of St. Jamet's, Jamaica, fifty feet high, and proportionably thick. The wood is hard, clouded, and takes a fine poliffi. The bark of the large trees is rough, th« cuticle thick and inert, and the inner bark thinner than 196 Materia Medica. [Part II. that of the young trees, but more fibrous. ^The bark is brought to us in pieces about a fpan in length, rolled, together, and a line or half a line in thicknefs, of a brown color on the furface, which is moft commonly covered with white lichens ; internally it is of a dark brown color, and very fibrous in its fraaure. It has at firft a fweetifh tafte, but after being chewed fome time it becomes extremely naufeous and bitter. Dr. Wright fays he made ufe of this bark in all cafes where Peruvian bark was indicated, and with the greateft fuccefs. It has often been confounded with the cinchona floribunda. (Willdenow's 7th fpecies) fo excellently analyzed by Fourcroy under the title of the Cinchona of St. Do- mingo, and which taken internally is apt to excite vomiting and purging. CINERES CLAVELLATI. (Lond. Dub.) See Cario- NAS POTASS/E IMPURUS. C1NNAMOMUM. (Lond.Dub.) See Laurus Cinna" MOMUM. CISSAMPELOS PAREIRA. Pareira Brava. Radix. (Lond. Dub.) Pareira brava. The root. Dioecia Monadelphia—Nat. ord. Sarmentacea. This is a perennial climbing plant which grows in the Weft India iflands and in South America. The root, which is officinal, is brought to us from Brazil, in pieces of different fizes, fome no bigger than one's finger, others as large as a child's arm ; it is crocked, and varioufly wrinkled on the furface ; outwardly ot a dark color, internally of a dull yellowifli, and interwoven with woody fibres ; fo that upon a tranfverfe feaion, a number of con- centric circles appear, croffed with fibres, which run from the centre to the circumference : It has no fmell ; the tafte is a little bitteriffi, blended with a fweetnefs like that of liquorice. This root is highly extolled by the Brazilians and Portuguefe, in a great variety of difeafes, particularly againft fuppreffions of urine, ne- phritic pains, and calculus. Geoffroy alfo found it ufeful in ne- phritic diforders, in ulcers of the kidneys and bladder, in humoral afthmas, and in fome fpecies of jaundice. The common people of Jamaica ufe a deco£tion of the roots for pains and weaknefs of the ftomach, proceeding from relaxation. The dofe of the root in fubftance is from twelve grains to half a drachm j in decoaion to two or three drachms. CiSTUS CRETICUS. Ladanum. Refina. (Lond.) Part II.] Materia Medica, 197 Cretan Ciftus. Ladanum. A refin. Willi, g. 1048.7^. 13.—Nat. ord. Afcyroidea. This is a perennial ffirub which grows in Syria, and more ef- pecially in the Grecian iflands. This refin is faid to have been formerly colleaed from the beards of goats who brow fed the leaves of the ciftus; at prefent, a kind of rake, with feveraj ftraps or throngs of fkins fixed to it, is drawn lightly over the fhrub, foas totakeup the unauous juice, which is afterwards fcraped off with knives. It is rarely met with pure, even in the places where it is produced; the duft, blown upon the plant by the wind, mingling with the vifcid juice, and the inhabitants alfo being faid to mix it with a certain black fand. In the ffiops two forts ate met with ; the beft (which is very rare) is in dark colored almoft black'maffes, of the confiftence of a foft plafter which grows ftill fotter upon being handled; of a very agreeable fmell, and of a light pungent bitteriffi tafte ; the other fort is harder, not fo dark colored, in long rolls coiled up ; this is of a much weaker fmell than the firft, and has a large admix- ture of a fine fand, which in the ladanum examined by the French Academy, made up three fourths of the mafs. Reaified fpirit ot wine almoft entirely diffolves pure ladanum, leaving only a fmall portion of gummy matter which has no tafte or fmell. CITRUS. Polyadelphia Icofandria.—Nat. ord. Pomacea. Sp. Citrus Aurantium. Folia, filores, aqua Jlillatitiaet oleum volatile florum, fruftus fuccus,fruclus immaturus, et cortex exterior. (Ed.) Aurantium Hifpalenfe. Folium, flos fruclus fuccus, et cortex exterior, (Lond.) Fruclus fuccus et cortex exterior, fruclus immaturus,filorum aqua flillatit\a. Seville orange. The leaves, flowers, diftilled water and effen- tial oil of the flowers, the juice and outer rind of the truit, and the unripe fruit. The orange tree is a beautiful evergreen, a native of Afia, but now abundantly cultivated in the fouthern puts ot Europe and in the Weft India iflands. There are feveral varieties of this fpecies but they may be all referred to the bitter or Seville orange, and the fweet or China orange. The leaves are neither fo aromatic nor fo bitter as the rind of the fruit, yet they have been celebrated by eminent phyficians as a powerful antifpafmodic in convulfive diforders, and efpecially in epilepfy ; with others they have entirely failed. The flowers (flores naphae) are highly odoriferous, and have been for fome time paft in great efteem as a perfume ; tlv \x tafte is fomewhat warm, accompanied with a degree of bitiernefs. They 3 193 Materia Medica. Part II.] yield their flavor by infufion to reaified fpirit, and in diftillation both to fpirit and water, (aqua florum naphse) ; the bitter matter is diffolved by water, and, on evaporating the decoaion, remains entire in the extraa. A very fragrant red colored oil, diftilled from thefe flowers, is brought from Italy under the name of oleum or efifentia neroli ; but oil of behen, in which orange flowers have been digefted, is frequently fubftituted for'it. The fraud, hawever, is eafily de- teaed, as the real oil is entirely volatile, and the adulterated is not. Orange flowers were at one time faid to be an ufeful remedy in convulfive and epileptic cafes ; but experience has not confirmed the virtues attributed to them. As by drying they lofe their vir- tues, they may be preferved for this purpofe by packing them clofely in earthern veffels, with half their weight of muriate of foda. The juice of oranges is a grateful acid liquor, confifting princi- pally ot critic acid, fyrup, extraaive, and mucilage; of confider- able ufe in febrile or inflammatory diftempers, for allaying heat, quenching thirft, and promoting the falutary excretions ; it is like- wife of ufe in genuine fcorbutus, or fea fcurvy. Although the Seville, or bitter orange as it is called, has alone a place in our pharmacopoeias, yet the juice of the China, or fweet orange, is much more employed. It is more mild, and lefs acid ; and it is employed in its moft fimple ftate with great advantage, both as a cooling medicine, and as an ufeful antifeptic in fevers of theworft kinds, as well as in many other acute difeafes, being highly bene- ficial as alleviating thirft. Dr. Wright applied the roafted pulp of oranges as a poultice to fetid fores in the Weft Indies, with very great fuccefs. The outer yellow rind of the fruit is a grateful aromatic bit- ter ; and proves an excellent ftomachic and carminative, promot- ing appetite, warming the habit, and ftreiigthening the tone of the vifcera. Orange peel appears to be confiderably warmer than that of lemons, and to abound more with effential oil ; to this circumftance, therefore, due regard ought to be had in the ufe of thefe medicines. The flavor of the firft is likewife fuppofed to be lefs perifhable than that of the other ; hence the London Col- lege employ orange peel in the fpirituous bitter tinaure which is defigned for keeping ; wbilft in the bitter watry infufion, lemon peel is preferred. A fyrup and diftilled water are for the fame reafon prepared from the rind of oranges in preference to that of lemons. The outer rind of the orange is the bafis of a conferve both in the Edinburgh and London pharmacopoeias ; and this is peihaps one of the moft elegant and convenient forms ot exhibiting it. Part II.] Materia Medica. 193 The unripe fruit dried are called Curacoa oranges. They vary in fize from that of a pea to that of a cherry. They are bitterer than the rind of ripe oranges, but not fo aromatic, and are ufed as a ftomachic. Sp. Citrus Medica. Fruclus, cortex fruclus, et ejus ole- um volatile. (Ed.) Limon. Succus, cortex exterior, et olettm effentia diSum. (Lond.) Succus, cortex exterior, ejufdemqueoleum effentiale. (Dub.) Lemon tree. The juice and outer rind, and its effential oil, of the fruit. The juice of lemons is fimilar in quality to that of oranges from which it differs little otherwife than in containing more ci- tric acid and lefs fyrup. The quantity of the former is indeed fo great, that the acid has been named from this fruit, Acid of Lemons, and is commonly prepared from it. The fimple ex- preffed juice will not keep on account of the fyrup, extraaiveand mucilage and quantity of water which it contains, which caufes it to ferment. It was therefore extremely defirable that an eafy method ffiould be difcovered of reducing it to fuch a ftate that it would not fpoil by keeping, and would be lefs bulky. Various means have been propofed and praaifed with this view. The juice has been evaporated to the confiftence of rob ; but this always gives an empyreumatic tafte, and does not fepar- ate the extraaive or mucilage fo that it is ftill apt to ferment when agitated on board of (hip in tropical climates. It has been expofed to froft, and part of the water been removed under the form of ice; but this is liable to all the former objeaions, and be- fides, where the lemons are produced in fufficient quantity, there is not a fufficient degree of cold. The addition of a quantity of alcohol to the infpiffated juice feparates the mucilage, but not the extraaive or fugar. By means, however, ot Scheele's procefs, as reduced to determinate quantities by Prouft, we can obtain the acid perfeaiy pure and cryftallized. To 94 parts of lemon juice, 4 parts of carbonate of lime are to be added ; the carbonic acid is feparated by effervefcence, and a quantity of infoluble citrate of lime is precipitated. By evaporat- ing the fupernatant liquor, another portion of citrite of lime is obtained. Thefe added together amount to about y\ parts, and require 20 parts of fulphuric acid, of the fpecific gravity of 1-1,5 to decompofe them. The fulphate of lime being nearly infoluble is precipitated, and the citric acid remains in folution, and is to be feparated by waffiing, and cryftallized by evaporation. If too much fulphuric acid be added, when the liquor is much concen- trated, it reaas upon the citric acid, and chars a portion of it.__ When this is the cafe, a little chalk muft be added. la* 4 200 Materia Medua. [Part II, By this or fome fimilar procefs, it is now rnanufaaured, in this country in large quantities, and fold under the name of Coxwell's Concrete Salt of Lemons. Citric acid is a powerful and agreeable antifeptic. Its powers are much increafed, according to Dr. Wright, by faturating it with muriate of foda. The mixture he recommends as poffeffing very great efficacy in dyfentery, remittent fever, the belly ach, ^ putrid fore throat, and as being perfeaiy fpecific in diabetes and licnteria. Citric acid is often ufed with great fuccefs for allay- ing vomiting; with this intention it is mixed with carbonate of potafs, from which it expels the carbonic acid with effervefcence. This mixture fhould be drunk as foon as it is made; or, the car- bonic acid gas, on which aaually the anti emetic powers of this mixture depends, may be extricated in the ftomach itfelf, by firft {"wallowing the carbonate of potafs diffolved in water, and drink- ing immediately afterwards the citric acid properly fweetened. The dofes are about a fcruple of the carbonate diffolved in eight or ten drachms ot water,and an ounce of lemon juice,or an equiv- alent quantity of citric acid. Lemon juice is alfo an ingredient in many pleafant refrigerant drinks, which are of very great ufe in allaying febrile heat and thirft. Of thefe the moft generally ufeful is lemonade, or diluted lemon juice, properly, fweetened. Lemonade, with the addition of a certain quantity of any good ardent fpirit, forms the well known beverage Punch, which is fometimes given as a cordial to the tick. The German writers order it to be made with arrack, as rum and brandy, they fay, are apt to occafion headach. But the faa is direaiy the reverfe, for of all fpirits arrack is moft apt to pro- duce headach. The lighteft and fafeft fpirits are thofe which contain leaft effential oil, or other foreign matters, and which have been kept the longeft time after their diftillation. The yellow peel is an elegant aromatic, and is frequently em- ployed in ftomachic tinaures and infufions; it isconfiderabiy lefs hot than orange peel, and yields in diftillation with water a lefs quantity of effential oil; its flavor is neverthelefs more perifh- able, yet does not arife fo readily with fpirit of wine; for a fpiri- tuous extraa made from lemon peel poffeffes the aromatic tafte and fmell of the fubjefct in much greater perfeaion than an extraa prepared in the fame manner from the peels of oranges. In the fhops a fyrup is prepared from the juice, and the peel is can- died ; the peel is an ingredient in the bitter infufions and wines ; the effential oil enters the volatile aromatic fpirit, or fpiritus ammonias compofitus, as it is now called, and fome other formulyj- COCCUS CACTI. (Ed.) Coccinella. (Lond.) Cochineal. Part II.] Materia Medica. Spl Cochineal is the dried body of the female of a heraiptercus infeft. It is found only in Mexico, and is nourished entirely on the leaves of the opuntia or nopal, (caaus coccinelliferus.) The wild cochineal, which is covered with a filky envelop, is lefs valuable than the cultivated cochineal, which is without that covering, but grows to a larger fize, and furnifhes a finer and more permament color. The Spaniards endeavor to confine both the infea and the plant on which it feeds to Mexico. But this attempt at monopoly will, we hope be fruftratcd by the ex- ertions of fome gentlemen in the Eaft Indies. The male only is furnifhed with wings, the female has none, and remains conftant- ly attached to the leaf of the caaus. During winter, the Mexi- cans preferve thefe infeas, with the fucculent leaves to which they are attached, in their houfes. In fpring, after the rainy fea- fon is over, they are transferred to the living plants, and in a few days they lay innumerable eggs and die. They are colleaed three times in the year; firft the dead mothers are gathered as foon as they have laid their eggs; in three or four months, the young which have grown to a fufficient fize are colleaed ; and in three or four months more, all the young are colleaed, large and fmall indifcriminately, except thofe which they preferve for breeding next year. They are killed by inclofing them in a bag and dipping them in hot water, and by expofing them on iron plates to the heat of the fire; 8co,ooo pounds are brought an- nually to Europe; and each pound contains at leaft 70,000 infeas. From their appearance, when brought to us, they were long fup- pofed to be the feed of fome plant. They are fmall, irregular, roundiffi bodies, of a blackiffi red color on the outfide, and a bright purple red within. Their tafte is acrid, bitteriffi and aftringent. They are ufed only for the fake of the fine color which they produce, and they are principally confumed by the fcarlet dyers. In pharmacy they are employed to give a beauti- ful red to fome tinctures. Their color is eafily extraaed, both by alcohol, water, and water of ammonia ; and in the dried infea it is not impaired by keeping for any length of time. COCHLEARIA. Willd.g. 1228. Tetradynamia Siliculofa.—Nat. ord. Siliquofx. Sp. 1. Cochlearia Officinalis. Herba. (Ed.) Cochlearia. Herba. (Dub.) Cochlearia hortenfis. Herba. (Lond.) Garden fcurvy grafs. The plant. This is an annual plant which grows on the fea ffiore of the northern countries of Europe, and is fometimes cultivated in gar- dens. As long as it is frefh it has a peculiar fmell, efpecially when bruifed, and a kind of faline acrid tafte, which it lofes com- 202 Materia Medica. [Part II. pletely by drying, but which it imparts by diftillation to water or alcohol. It alfo furnifhes an effential oil, the fmell of which is jfo ftrong as to make the eyes water. The frefh plant is a gentle ftimulant and diuretic, and is chiefly ufed for the cure of fea fcurvy. It is employed externally as a gargle in fore throat, and fcorbutic affeaions of the gums and mouth. It may be eaten in fubftance in any quantity, or the juice may be expreffed from it, or it may be infufed in wine or water, or its virtues may be extraaed by diftillation. Sp. 8- Cochlearia Armoracia. Radix. (Ed.) Raphanus ruflicanus. Radix. (Lond. Dub.) Horferadiffi. The root. This perennial plant is fometimes found wild about river fides, and other moift places ; for medicinal and culinary ufes, it is cultivated in gardens ; it flowers in June, but rarely perfeas its feeds in this country. Horferadiffi root has a quick pungent fmell, and a penetrating acrid tafte; it neverthelefs contains in certain veffels a fweet juice, which fometimes exudes upon the furface. By drying, it lofes all its acrimony, becoming firft fweetiffi, and afterwards almoft infipid ; if kept in a cool place, covered with fand, it retains its qualities for a confiderable time. The medical effe£ts of this root are, to flimulate the folids, and promote the fluid fecretions; it feems to extend its aaion through the whole habit, and affect the minuteft glands. It has frequently done fervice in fome kinds of fcurviesand other chronic diforders proceeding from a vifcidity of the juices, or obftruaions of the excretory duas. Sydenham recommends it likewife in dropfies, particularly thofe which fometimes follow intermittent fevers. Both water and reaified fpirit extraa the virtues of this root-by infufion, and elevate them in diftillation; along with the aqueous fluid, an effential oil arifes, pofiefling the whole tafte and pungen- cy ot the horferadiffi. COCOS BUTYRACEA. Oleum nucis fixum. (Ed.) The mackaw tree. The fixed oil of the nut, commonly called Palm Oil. Pahnce.—Nat. ord. Palma. This tree is a native of South America. The fruit is triangu- lar, yellow, and as big as a plumb. The nut or kernel by decoc- tion yields the oleum palmas of the (hops. This oil has the con- fidence of butter, a golden yellow color, the fmell of violets, and a fweetiffi tafte. When well preferved, it keeps feveral years without becoming rancid. When fpoiled, it lofes its yellow color and pleafant fmell. It is faid to be often imitated with axunge, colored with tumeric, and fcented with Florentine iris Part II.] Materia Medica, 203 root. It is rarely ufed in medicine, and only externally as an emollient ointment. COLCH1CUM AUTUMNALE. Radix. (Ed.) Colchicum. Radix. (Lond. Dub.) Meadow faffron. Willd. g. joy.fip. 1. Hexandria Trigynia.—Nat. ord. Liliacea. Meadow Saffron is a perennial, bulbous rooted plant, which grows in wet meadows in the temperate countries of Eu- rope. It flowers in the beginning of autumn, at which time the old bulb begins to decay, and a new bulb to be formed. In the following May the new bulb is perfeaed, and the old one wafted and corrugated. They are dug for medical ufe in the beginning of fummer. The fenfible qualities of the frefh root are very various, accord- ing to the place of growth, and feafon of the year. In autumn it is inert; in the beginning of fummer highly acrid ; fome have found it to be a corrofive poifon, others have eaten it in confider- able quantity without experiencing any effea. When it is pof- feffed of acrimony, this is of the fame nature with the acrimony ot garlic, and is entirely deftroyed by drying. Stork, Collin and Plenk have celebrated its virtues as a diuretic in hydrothorax and other dropfies. But it is at beft a very uncertain rem«dy. The expreffed juice is ufed in Al face to deftroy vermin in the hair. COLOCYNTHIS. (Lond. Dub.) See Cucumius. COLOMBA. (Lond. Ed.) ' Columbo. (Dub.) Colomba. The root. This is the root of an unknown plant, which, however, is co«- jeaured by Willdenow to be a fpecies of bryonia. It was fup- pofed to have its name from a city in Ceylon, from which it is fent overall India. But more recent accounts fay, that it is pro- duced in Africa, in the country of the Caffres, and that it forms, an important article of commerce with the Portuguefeat Mozam- bique, in the province of Tranquebar. It is generally brought in tranfverfe feaions, from half an inch to three inches in diame- ter, rarely divided horizontally. This is evidently done to facil- itate its drying, for the large pieces are all perforated with holes. The bark is wrinkled and thick, of a dark brown color on the outfide, and bright yellow within. The pith in the centre is fpon- gy, yellowifh}and flightly ftriped. Its fmell is flightly aromatic, and readily loft when not preferved in clofe veffels ; its tafte is unpleafant, bitter, and fomewhat acrid ; the bark has the ftrongeft tafte; the pith is almoft mucilaginous. Its effential condiments are bitter extraaive, and a great deal of mucilage. It is accord- 204 Materia Medica. [Part II, ingly more foluble in water than in alcohol. In India it is much ufed in difeafes attended with bilious fymptoms, particularly in cholera ; and it is faid to be fometimes very effeaual in other cafes of vomiting. Some confider it is as very ufelul in dyfpepfia. Half a drachm of the powder is given repeatedly in the day. Its ufe in medicine has been particularly recommended to the attention of Praaitioners by Dr. Percival of Manchefter in his Experimen- tal Effays ; and it has in general been found to anfwer expeaa- tion ; but it is to be regretted, that it is not fo regularly import- ed as to admit of our ffiops being fupplied with'it of good quality. Hence, when prefcribed, it is often exhibited in a very decayed ftate. CONIUM MACULATUM. Folia, Semen. (Ed.) Cicuta. Herba, fiosj'emen. (Lond.) Herba,femina nondum matura. (Dub.) Hemlock. The leaf, flower, and feed. Willd.g. 533. fp. 1. PentandriaDigynia.—Nat. ord. Umbellata. ThIo is a large biennial umbelliferous plant,which grows very commonly about the fides of fields, under hedges, and in moift fhady places. As it may eafily be confounded with other plants of the fame natural order, which are either more virulent or lefs aaive, we (hall give a full defcription ot its botanical charaaers. The root is white, long, of the thicknefs of a finger, contains when it is young a milky juice, and refembles both in fize and form the carrot. In fpring it is very poifonous, in harveft lefs fo. The ftalk is often three, four, and even fix feet high, hollow, fmooth, not befet with baifs, and marked with red or brown fpots. The leaves are large, and have long and thick foot (talks, which, at the lower end, affume the form of a groove, and furround the fiem. From each fide of the foot ftalk other foot (talks arife, and fiom thefe a ftill fmaller order, on which there are feffile, dark green, fhining, lancet ffiaped, notched leafits. The umbels are terminal and compound. The flowers confift of five white hear: fhaped leaves. The feeds are flat on the one fide, and hemifphe- rical on the other, with five ferrated ribs. This laft circumftance with the fpots on the ftalks, and the peculiar very naufeous fraell of the plant, fomewhat refembling the urine of a cat, ferve to dif- tinguiffi it from all other plants. We muft not be milled by its officinal name Cicuta, to confound it with the Cicuta virofaot Linnaeus, which is one of the moft virulent plants produced in this country, and readily diftinguifhable from the conium, by hav- ing its roots always immerfed in water, which thofe of the conium never are. The poffibility of this miftake (hews the propriety of denominating all vegetables by their fyftematic names, as the Edinburgh College now do. The other plants which have been miftaken for the conium maculatum are, the iethufa cynapium, Part II.] Materia Medica. 205 caucalis arithrifcus, and feveral fpecies of chaerophyllum, efpecial- ly thebulbofum, which however, is not a native of this country. Hemlock fhould not be gathered unlefs its peculiar fmell be ftrong. The leaves ffiould be colleaed in the month of June, when the plant is in flower. The leafits are to be picked off, and the foot ftalks thrown away. The leafits are then to be dried quickly in a hot fun, or rather on tin plates before a fire, and pre- ferved in bags of ftrong brown paper, or powdered and kept in clofe veffels, excluded from the light ; for the light foon difli- pates their green color, and with it the virtues of the medicine. Frefh hemlock contains not only the narcotic but alfo the a- erid principle ; of the latter much, and of the former little, is loft by drying. The whole plant is a virulent poifon, but varying very much in ftrength according to circumftances. When taken in an over dofe, it produces vertigo, dimnefs of fight, difficulty of fpeech, naufea, putrid eruaations, anxiety, tremors, and paralyfis of the limbs. But Dr. Stork found, that in fmall dofes it may be taken with great fafety ; and that, without at all difordering the conftitution, or even producing any fenfible operation, it fome- times proves a powerful refolvent in many obftinate diforders. In fcirrhus, the internal and external ufe of hemlock has been found ufeful, but then mercury has been generally ufed at the fame time. In open cancer it often abates the pains, and is free from the conftipating effeas of opium. It is likewife ufed in fcrofulous tumors and ulcers, and in other ulcers thatare only defined by the term ill condition. It is alfo recommended by fome in chincough, and various other difeafes. Its moft common and beft form, is that of the powdered leaves, in the dofe at firft of two or three grains a day, which in fome cafes has been gra- dually increafed to upwards of two ounces a day, without produc- ing giddinefs. An extraa from the feeds is faid to produce gid- dinefs fooner than that from the leaves. CONTRAYERVA. (Lond. Dub.) See Dorstenia. CONVOLVULUS. Willd'. g. 323. Pentandria Monogynia___Nat. ord.Campanacea. Sp. 4. Convolvulus Scammonia. Gummi refina. (Ed.) Scammonium. Gummi refina. (Lond* Dub.) Scammony. The gum refin. The fcammony convolvulus is a climbing perennial plant, which grows in Syria, Myfia and Cappadocia. The roots which are very long and thick, when frefh contain a milky juice. To obtain this, the earth is removed from the upper part'of the roots, and the tops of thefe cut obliquely off. The milky juice which flows out, is colleaed in a fmall veffel, funk in the earth at the 206 Materia Medica. [Part II. lower end of the cut. Each root furnifhes only a few drachms, but it is colleaed from feveral veffels, and dried in the fun. This is the true and unadulterated fcammony. It is light, of a dark grey color, but becomes of a whitifh yellow when touched with the wet finger, is ffiining in its fraaure, has a peculiar naufeous fmell, and bitter acrid tafte, and forms with water a greenifh mil- ky fluid, without any remarkable fediment. In this ftate ot pu- rity it feldom reaches us, but is commonly mixed with the ex- preffed juice of the root, and even of the ftalks and leaves, and often with flour, fand or earth. The beft to be met with in the ffiops comes from Aleppo, in light fpongy maffes, eafily friable, of a ffiining afh color, verging to black; when powdered, of a light grey or whitifh color. An inferior fort is brought from Smyrna in more compaa ponderous pieces, of a darker color, and full of fand and other impurities. Refin is the principal constituent of fcammony. Sixteen ounc- es of good Aleppo fcammony, give eleven ounces of refin and three and a half of watry extraa. Scammony is an efficacious and ftrong purgative. Somehave~ condemned it as unfafe, and laid fundry ill qualities to its charge ; the principal ot which is, that its operation is uncertain, a fulldofe proving fometimesineffeaual, whilftatothers a much fmalieronc occafions dangerous hypercatharfis. This difference however, is owing entirely to the different circumftances of the patient, and not to any ill quality, or irregularity of operation, of the medi- cine; where the inteftines are lined with anexceffive load of mu- cus, the fcammony paffes through, without exerting itfelf upon them ; where the natural mucus is deficient, a fmall dofe of this or any other refinous cathartic, irritates and inflames. Many have endeavored to abate the force of this drug, and to correct its imaginary virulence, by expofing it to the fumes of fulphur, diffolving it in acids, and the like ; but thefe only deftroy a part of the medicine, without making any alteration in the reft. Scam- , mony in fubftance, judicioufly managed ftands not in need of any corfeaor ; if triturated with fugar or with almonds, it becomes fufficiently fafe and mild in its operation. It may likewife be conveniently diffolved by trituration, in a ftrong decoaion of li- quorice, and then poured off from the feces. The common dofe of fcammony is from three to twelve grains. Sp. 61. Convolvulus Jalap a. Radix. (Ed.) jfalapium- Radix. (Lond.) Jalapa. Radix. (Dub.) Jalap. The root. Jalap is another climbing perennial fpecies of convolvulus. It is an inhabitant of Mexico and Vera Cruz. It is brought to us in thin tranfverfe flices.whichare covered with a blackiffi wrink- led bark, and are of a daik grey color internally marked with Part II.] Materia Medica. 20? darker or blackiffi flripes. It has a naufeous fmell and tafte, and when fwallowed it affeas the throat with a fenfe of heat, and oc- cafions a plentiful difcharge ot faliva. When powd«red it has a yellowiffi grey color. Such pieces ffiould be chofen as are moft compaa, hard, weitrh- ty, dark colored, and abound moft with black circular ftrise-and fhining points ; the light, whitiffi, friable, worm eaten pieces muft be rejeaed. Slices of bryony root are faid to be fometimes mixed with thofe of jalap ; thefe may be eafily diftinguifhed by their whiter color and lefs compaa texture. Its aaive conftituent is a refinous fubftance, of which the root furnifhes about one tenth of its weight. Jalap in fubftance, taken in a dofe of about half a drachm (lefs or more, according to the circum (lances of the patient) in pletho- ra, or cold phlegmatic habits, proves an effeaual, and in general a fafe purgative, performing its office mildly, feldom occafioning naufea or gripes, which teo frequently accompany the other ftrong cathartics. In hyphochondriacal diforders, and' hot bilious tem- peraments, it gripes violently, if the jalap be good; but rarely takes due effea as a purge. An extraa made by water purges almoft univerfally, but weakly ; and at the fame time has a con- fiderable effea by urine; the root remaining after this procefs gripes violently. The pure refin, prepared by fpirit of wine, oc- cafions moft violent gripings, and other diftreffingfymptoms, but fcarce proves at all cathartic ; triturated with fugar, or with al- monds, into the form of an emulfion, or diffolved in fpirit, and mixed with fyrups, it purges plentifully in a fmall dofe, without occafioning much diforder ; the part of the jalap remaining after the feparation ot the refin, yields to water an extraa, which has no effea as a cathartic, but operates powerfully by urine. Its offieinal preparations are an extraa made with water and fpirit, a fimple tinaure, and a compound powder. COPAIFERA OFFICINALIS. Refina. (Ed.) Balfamum Copaiva. (Lond.) Balfamum Copaiba. (Dub.) Copaiva tree. The refin. Willd.g. 88o.y£>. x.Decandria Monogynia.—Nat. ord.Dumofa. The tree which produces this refin is a native of the Spaniffi Weft India iflands, and of fome parts of the continent of South America. It grows to a large fize, and the refinous juice flows in confiderable quantities from incifions made in the trunk. The juice is clear and tranfparent, of a whitiffi or pale vellow- ifh color, an agreeable fmell, and a bitteriffi pungent taiie. It is ufually about the confiftence of oil or a little thicker ; when long kept, it becomes nearly as thick as honey, retaining its clear- Kefs ; but has not been obferved'to grow dry of folid, as moft of 208 Materia Medica. [Part II. the other refinous juices do. The beft refin of copaiva comes from Brazil ; but we fometimes meet with a thick fort which is not at all tranfparent, or much lefs fo than the foregoing, and, generally has a portion of turbid watery liquor at the bottom.— This is probably either adulterated by the mixture of other fubftan- ces, or has been extraaed by decoaion from thebark and branch- es of the tree; its fmell and tafte are much lefs pleafant than thofe ot the genuine refin. Pure refin or copaivadiffolves entirely in alcohol ; the folution has a very fragrant fmell. Diftilled with water it yields a large quantity of a limpid effential oil, but no benzoic acid; it is there- fore not a balfam but a combination of refin and effential oil. The refin of copaiva is an ufeful corroborating detergent medi- cine, accompanied with a degree of irritation. It ftrengthens the nervous fyftem, tends to loofen the belly ; in large dofes proves purgative, promotes urine, and cleans and heals exulcerations in the urinary paffages, which it is fuppofed to perform more effec- tually than any of the other refinous fluids. Fuller obferves, that it gives the urine an intenfely bitter taftej but not a violet fmell as the turpentines do. This refin has been principally celebrated in gleets and the fluor albus, and externally as a vulnerary. The dofe of this medicine rarely exceeds twenty or thirty dropsy though fome authors direa fixty or upwards. It may be conve- niently taken in the form of an oleofaccharum, or in that of an emulfion, into which it may be reduced, by triturating it with al- monds, with a thick mucilage of gum Arabic, or with the yolk of eggs, till they are well incorporated, and then gradually adding i proper quantity of water. CORALLIUM RUBRUM. (Lond.) Seelsis. CORIANDRUM SATIVUM. Semen. (Ed.) Coriandrum. Semen. (Lond. Dub.) Coriander. The feeds. Willd.g. 552.fip. 1. Pentandria Digynia—Nat. ord. Umbellatd. Coriander is an annual, umbelliferous plant, a native of the fouth ot Europe, differing from all the others of that clafs in pro- ducing fpherical feeds. Thefe, when frefh, have a ftrong^difa- greeable fmell, which improves by drying, and becomes fufficient- ly grateful; they are recommended as carminative and flora- achic. - CORNU CERVINUM. (Dub.) SeeCERVus. CORTEX PERUVIANAS. (Dub.) See Cinchona. frart II. j Materia Medica. 209 CRETA. (Lond. Dub.) See Carbonas Calcis. CROCUS SATIVUS. Florisfiigmata. (Ed.) Crocus. Florisfiigma (Lond.) Filamenta. (Dub.) Common faffron. The fummits of the piflils. Willd.g. 92.fp. l.Triandria Monogynia.—Nat. ord. Liliacea. Croc u s is a bulbous rooted perennial plant, probably a native of the Eaft, although it is now found wild, in England and other temperate countries of Europe. It is very generally cultivated as an ornament to our gardens, and in fome places for the faffrort which is formed of the dried fummits of thepiftil, and not of the filaments, as dated by the Dublin College. Each flower has one piftil, the fummit ot which is deeply divided into three flips, which are of a dark orange red color, verging to white at the bafe, and are fmooth and ffiining. Their fmell is pleafant and 2romatic, but narcotic ; their tafte a fine aromatic bitter, and they immediately give a deep yellow color to the faliva when chew- ed. The flowers are gathered early in the morning, juft before they open ; the fummits of the piflils are picked out, very care- fully dried by the heat of a ftove, andcompreffed into firm cakes. In this ifland the Englifh faffron is luperior to what is imported from other countries, and may be diftinguifhed by its blades being broader. On the Continent they reckon the Au (Irian and the French from Gatinois the beft. The Spaniffi is rendered ufelefs, by being dipt in oil with the intention of preferving it. Saffron fhould be chofen frefh, not above a year old, in clofe cakes, neither dry, nor yet very moift ; tough and firm in tearing ; difficulty pulver- izable; of a fiery orange red color ; of the fame color within as without; of a ftrong, acrid, diffufive fmell ; and capable of col- oring a very large proportion of water or alcohol. Saffron which does not color the fingers when rubbed between them or ftains them with oil, has little fmell or tafte, or a mufty or foreign fla- vor, is too tender, and has a whitifh, yellow, or blackiffi color, is bad. It is faid that it is fometimes adulterated with the fibres of fmoked beef, and with the flowers of the carthamus tinaorius, Calendula officinalis, &C. The impofition may be deteaed by the.abfence of the white ends, which may be obferved in the real faffron, by the inferior coloring power, and by the want of fmell, or bad fmell when thrown on live coals. By diftillation with water, faffron furnifhes a fmall propor- tion of effential oil, of a golden yellow color, heavier than water, and poffeffing the characteriftic fmell in an eminent degree. Its Other principal conftituent is extraaive, and it is the fubftance from which Hermbftadt obtained it in the ftate of greateft pu- $10 Materia Medica. [Part II, On account of the great volatility of the aromatic part of the faffron, it ffiould be wrapt up in bladder, and preferved in a box or tin cafe. Saffron imparts the whole of its virtue and color to reaified fpirit, proof fpirit, wine, vinegar and water ; a tincture drawn with vinegar, lofes greatly of its color in keeping ; the watry and vinous, tinaures are apt to grow four, and then lofe their color alfo ; that made in pure fpirit keeps in perteaion tor many years. Saffron is a very elegant aromatic ; befides the virtues which it has in common with alt the bodies of that clafs, it has been alleg- ed that it remarkably exhilarates, raifes the fpirits, and is deferv- edly accounted one of the higheft cordials ; taken in large dofes, it is faid to occafion immoderate mirth, involuntary laughter, and the ill effeas which follow from the abufe of fpirituous liquors. The medicine is alfo faid to be particularly ferviceable in hyfte- ric depreffions, or obftruaion of the uterine fecretions, where other aromatics, even thofe of the more generous kind, have lit- tle effea. But fome experiments made by Dr. Alexander ferve to (hew that it is much lefs powerful than was once imagined ; and it was given in the Edinburgh Infirmary by Dr. Henry Cul- len, even to the extent of half an ounce a day, in feveral hyfteri- cal cafes, without any fenfible effea whatever ; fo that of late the eftimation in which it was held as a medicine has been on the de- cline. CROTON ELEUTHERIA. Cortex. (Ed.) Swart;. Prod. Cafcarilla. Cortex. (Lond. Dub.) Eleutheria or Cafcarilla. The bark. Monoecea Adelphia.—Nat. ord. Tricocca. This bark, is imported into Europe from, the Bahama iflandi, and particularly from one of them of the name of Eleutheria ; from which circumftance it was long known by the title of Eleu- theria. But Dr. Wright alfo found the tree on the fea ffiore in Jamaica, where it is common, and rifes to about twenty feet. It is the Clutia eleuteria of Linnaeus ; the bark of whofe Crotqn cafcarilla has none of the fenfible qualities of the cafcarilla of the (hops. The cafcarilla is in general brought to us either in curled pieces, or rolled up into ffiort quills, about an inch in width, fome- what refembling in appearance the Peruvian bark. It is covered on the outiide with a rough whitiffi matter ; and in the infide;it is ot a brownifh caft. When broken it exhibits a frnootb, clofe, dark brown furface. This bark, when freed from the outer whitiffi coat.which is in- fipid and inodorous, has a light agreeable fmell, and a moderate- ly bitter tafte, accompanied with a confiderable aromatic warmth. Jt is eafily inflammable, and yields, when burning, a very tra- Part. II.] Materia Medica. 211 grant fmell, refembling that of mufk ; a property which diftin- guiffies the cafcarilla from all other barks. Its aaive conftituents are aromatic effential oil and bitter ex- traaive. Its virtues are partially extraaed by water, and totally by rec- tified fpirit; but it is moft .effectual when given in fubftance. It produces a fenfe of heat, and excites the aaion of the ftomach ; and it is therefore a good and pleafant llomachic, and may be em- ployed with advantage in flatulent colics, internal hasmorrhagies, dyfenteries, diarrhceas, and fimilar diforders. As the effential oil is diffipated in making the extraa, this pre- paration aas as fimple bitter. It was much employed by the Stahliaiisin intermittent fever, from their fear of ufnig Cinchona bark, to which, however, it is much inferior in efficacy. CUBEBA. (Lond.) See Piper. CUCUMIS AGRESTIS. (Lond. Dub.) See Momordica. CUCUMIS COLOCYNTHIS. Fruclus, corticefeminibufi 4a hydro oxide of copper, Water, to J 33 fulphuric acid. 25 water of cryftallization. 100 The fulphate of copper has a ftrong, ftyptic, metallic tafte, and is chieflv' uf.d externally as an efcharotic for deftroying warts, callous edges, and fungous excrefcences, as a ftimulant applica- tion to ill conditioned ulcers, and as a ftyptic to bleeding furfaces. Taken internally, it operates, in very fmall dofes, as a very pow- erful emetic. It has, however, been exhibited in incipient phthif- is pulmonalis, intermittent fever, and epilepfy ; but its ufe is not free from danger. CURCUMA LONGA. Curcuma. Radix. (Lond.) -*• Turmeric. The root. Willd.g. 1 i.fp.i.Monandria Monogynia. Nat. ord. Scitaminea. Turmeric is a perennial plant, a native of the Eaft Indies. The roots are tuberous, knotty and long, wrinkled, externally of a pale yellow color, and internally of a ffiining faffron brown. They have a weak aromatic fmell, and a flightly bitter aromatic tafte. They contain a very little effential oil, but their chief conftituent may be extraaed by water, and is an aromatic bitter. Turmeric, when taken internally, tinges the urine of a deep yellow color, and aas as a gentle ftimulant. It has been cele- brated in difeafes ot the liver, jaundice, cachexy, dropfy, inter- mittent fevers, &c. But its internal ufe in this country is almoft confined to its being a principal ingredient in the compofition of curry powder, in which form it is ufed in immenfe quantities in the Eaft Indies. It is alfo a valuable dye fluff, and an excellent chemical teft of the prefence of uncombined alkalies ; for the yel-i low color of turmeric is changed by them to a reddiffi brown. CYDONIA MALUS. (Lond.) See Pyrus. CYNARA SCOLYMUS. Cinara. Folium. (Lond.) Cinara Scolymuf. Folia. (Ed.) Cinara Hortenfis. Folia. (Dub.) Artichoke. The leaves. Syngenefia Polygamia aqualis.—Nat. ord. Compofita capitata. The artichoke is a perennial plant, indigenous in the fouth of Europe, but very frequently cultivated, in our gardens for culi- flary purpofes. £T4 216 Materia Medica. [Part II, The leaves are bitter, and afford by expreffion a confiderable quantity of juice, which is faid to be diuretic, and to have been fuccefsfully ufed in dropfy. CYNOSBATUS. (Lond.) See Rosa Canina. DAPHNE MEZEREUM. Radicis Cortex. (Ed.) Mezereum. Radicis Cortex. (Lond.) Mezereon. Radix,Cor- Ux. (Dub.) Mezeieon, or (purge laurel. The bark of the root. Willd.g. jy%.fp. i. Oclandria Monogynia. Nat. ord. Vepreculx. Mezereon is a ft rub which grows in woody fituations in the northern parts of Europe, and is admitted into our gardens from its flowering in winter. The bark which is taken from the trunk, larger branches, and root, is thin, ftriped reddifh, commonly cov- ered with a brown cuticle, has no fmell, and when chewad ex- cites an infupportable fenfation of burning in the mouth and throat. When applied to the fkin in its recent ftate, or infufed in vine- gar, it raifes blifters. The root was long ufed in the Lifbon diet drink, for venereal complaints, particularly nodes and other fymptoms refifting the ufe of mercury. The bark of the root contains moft acrimony, though fome prefer the woody part. Mezereon has alfo been ufed with good effeas in tumors and cutaneous eruptions not vene- real. Dr. Cullen fays that it aas upon the urine, fometimes giving it a filamentous appearance, and upon the perfpiration, without di- miniffiing the ftrength remarkably ; and that in irritable habits it quickens the pujfe, and increafes the heat of the whole body. But Mr. Pearfon of the Lock Hofpital fays, that excepting a cafe or two of lepra, in which a decoaion of this plant conferred tem- porary benefit, he very feldom found it poffeffed ot medicinal vir- tues, either in fyphilis, or in the fequelae of that difeafe. In fcro- fula, or in cutaneous affeaions, it is employed chiefly under the form of decoaion; and it enters the decoftum farfapatillae com- pofitum of the London College ; but it has alfo been ufed in pow- der, combined with fome inaaive one, as that of liquorice root. It is apt to occafion vomiting and purging ; fo muft be begun in grain dofes, and gradually increafed. It is often combined with mercury. The ferries are ftill more acrid than the bark, and they have even been known to produce fatal effeas on children, who have been tempted by their beauty to eat them. It is faid that they are fometimes infufed in vinegar, to make it more pungent, and appear ftronger. fart II.] Materia Medica. 217 DATURA STRAMONIUM. Herba. (Ed.) Stramonium officinale. Thorn apple. The plant. Willd.g. 377.fp. 2.Pentandria Monogynia. Nat.oxd.Sofanacea. The thorn apple is an annual plant, a native of America, but now growing wild on dry hills and uncultivated places in England and oiher parts of Europe. The leaves are dark green, feffile, targe, egg ffiaped, pointed, angular, and deeply indented, of a dif- agreeable fmell and naufeous tafte. Every part of the plant is a ftrong narcotic poifon, producing vertigo, torpor, death. The beft antidote to its effeas is faid to be vinegar. Dr. Stbrk firft tried it as a remedy in mania and melancholy with confiderable fuccefs. Severalcafes of the fame difeafes were alfo cured or relieved by it, under the diieaion of different Swe- diffi phyficians ; and although in other experiments it frequently failed, we think that it deferves the attention of praaitioners, and well merits a trial, in affeaions often incurable by other means. Befides maniacal cafes, the ftramoniu'm has been alfo employed, and fometimes with advantage, in convulfive and epileptic affec- tions. It is not only taken internally, but has alfo been ufed ex- ternally. An ointment prepared from the leaves of the ftramo- nium has been faid to giveeafe in external inflammations and hae- morrhoids. The infpiffated juice of the leaves has been commonly ufed, but its exhibition requires the greateft caution. At firft one fourth of a grain is a fufficient dofe. The powder of the leaves or feeds promifes to furnifh a more certain or convenient formula than the infpiffated juice. DAUCUS CAROTA. Semen. (Ed.).^ Daucusfylvefiris. Semen. (Lond. Dub.) Wild Carrot. The feed. Willd.g.530. fp. 1.Pentandria Digynia.—Nat. ord. Umbellattt. This is a biennial plant, which grows wild in Britain, and is cultivated in great quantities as an article of food. The feeds, efpecially of the wild variety, have a moderately warm pungent tafte, and an agreeable aromatic fmell. They are,carminative, and are faid to be diuretic. The rotks efpecially of the cultivated yariety, contain much mucilaginous and faccharine matter, and are therefore highly nutritious and emollient. When beaten to a pulp, they form an excellent application to carcinomatous and ill conditioned ulcers, allaying the pain, checking the fuppuration and fetid fmell, and foftening the callous edges. DELPHINIUM STAPHISAGRIA, Staphifagria. Semen. (Lond. Dub.} Staveiacr.e. The feed. 213 Materia Medica. £Part. th Willd.g. 1061.fip. 13. Polyandria Trigynid.—Nat. ord. MuL tifiliqua. S tavesacre. is a biennial plant, a native of the fouth of Eu- rope. The feeds are ufually brought from Italy. They are large and rough, of an irregular triangular figure, of a b'ackifh cole»r on the outfide, and yellowifh or whitiffi within ; they have a difarrreeable fmell, and a very naufeous, bitteriffi, burning tafte. Stavefacre was employed by the ancients as a cathartic ; but it operates with fo much violence, both upwards and downwards, that its internal ufe has been, among the generality of praaition- ers, for fome time laid afide. It is chiefly employed in external applications for fome kinds ot cutaneous eruptions, and for de- ftroying lice and other infeas; infomuch, from this virtue it had received its name, in different languages. DIANTHUS CARYOPHYLLUS; Flares. (Ed.) Caryophillum rubrum. Flos. (Lond. Dub.) Clove Gilly flowers. The flowers. Willd.g. Sg^.fp. 9. Decandria Digynia. Nat. ord. Caryopkilleai This fpecies of dianthus is a native of Italy, and is perennial. By cultivation, its varieties have increafed to a very great num- ber, and they form one of the greateft ornaments of our gardens. Moft of thefe are termed Carnations, but the variety which is »f- ficinal furpaffes all the others in the richnefs of its fmell, and is alfo diftinguifhed by its color* being of an uniform deep crimfon. Their only ufe in pharmacy is to give a pleafant flavor and beau- tiful color to an officinal fyrup. DIGITALIS PURPUREA. Folia. (Ed.) Digitalis. , Folium. (Lond. Dub.) Foxglove. The leaves. Willd. g. n55. fp. i. Didynamia Angiofpermia.—Nat. ord. Solanacea. This is an indigenous biennial plant, very common on hedge- banks, ancrfides of hills, in dry, gravelly, or fandy foils, and the beauty of its appearance has gained it a place in our gardens and fhrubberies. The leaves^are large, oblong, egg ffiaped, foft, cov- ered with hairs, and ferrated. They have a bitter, very naufeous tafte, with fome acrimony. Its effeas when fwallowed are, 1. To diminifh the frequency of the pulfe. 2. To diminifh the irritability o the fyftem 3-- To increafe the aaion of the abforbents. 4. To increafe the difcharge by urine. In exceffive dofes, it produces vomiting, purging, dimnefs of fight,,vertigo, dilirium, hiccough, convulfions, collapfe, death. For thefe fymptoms the beft remedies are cordials and ftimulants. Part II.] Materia Medica. 21g Internally,digitalis has been recommended, I. In inflammatory difeafes, from its very remarkablepow* erof diminifhing the velocity of the circulation. 2. In aaive haemorrhagies, in phthifis. 3. In fome fpafmodic affeaions, as in fpafmodic afthma, palpitation, &c. 4. In mania from effufion on the brain. 5. In anafarcous and dropfical effufions. 6. In fcorfulous tumors. 7. In aneurifm of the aorta, we have feen it alleviate the the moft diftreffing fymptoms. Externally it has been applied to fcrofulous tumors. It may be exhibited, 1. In fubftance, either by itfelf, or conjoined with fome aro- matic, or made into pills with foap or gum ammoniac. Wither- ing direas the leaves to be gathered after the flowering ftem has (hot up, and about the time when the bloffoms are coming forth. He rejeas the leaf ftalk, and middle rib of the leaves, and dries the remaining part either in funffiine or before the fire. In this ftate they are eafily reduced to a beautiful green powder, of which we may give at firft one grain twice a day, and gradually increafe the dofe until it aa upon the kidneys, ftomach, pulfe and bowels, when its ufe muft be laid afide or fufpended. 2. In infufion. The fame author direas a drachm of the dried leaves to be infufed for four hours in eight ounces of boiling wa- ter, and that there be added to the drained liquor an ounce of any fpirituous water, for its prefervation. Halt an ounce or an ounce of this infufion may be given twice a day. 3. In decoaion. Darwin direas that four ounces of the frefh leaves be boiled from two pounds of water to one, and half an ounce of the drained decoaion be taken every two hours, for four or more dofes. 4. In tinaure. Put one ounce of the dried leaves coarfely pow- dered into four ounces of diluted alcohol; let the mixture ftand by the fire fide twenty four hours, frequently fhaking the bottle; and the faturated tincture, as Darwin calls it, muft then be fepar- ated from the refiduum by draining or decantation. Twenty drops of this tinaure may be taken twice or thrice a day. The Edin- burgh College ufe eight ounces of diluted alcohol to one of the powder, but let it digeft feven days. 5. The expreffed juice and extraa are not proper forms of ex- hibiting this very aaive remedy. When the digitalis is difpofed to excite loofenefs, opium may be advantageoufly conjoined with it ; and when the bowels are tardy, jalap may be given at the fame time, without interfering with its diuretic effects. During its operation in this way, the pa- tient fhould drink very freely. 220 Materia Medica. [P^t II. DOLICHOS PRURIENS. Pokes leguminis rigida. (Ed.) Dolichos. Seta leguminum- (DuM.) Cow itch. The ftiff hairs which cover the pods. Diadelphia Decandria.—Nat. ord. Papilionacea. The dolichos is^a climbing plant growing in great abundance in warm climates, particularly in the Weft Indies. The pods are about four inches long, round, and as thick as a man's finger. Theoutfide of the pods is thickly befet with ftiff brown hairs, which, when applied to tbe fkin, occafion a moft intolerable itch- ing. The ripe pods are dipped in fyrup, which is again fcraped off with the knife. When the fyrup is rendered by the hairs as thick as honey it is fit for ufe. It a&s mechanically as an anthelmin- tic, occafions no uneafinefs in the primae viae, which are defend- ed by mucus, and may be fafely taken from a tea fpoonful tq a table fpoonful in the morning failing. The worms are faid tQ appear with the fecond or third dofe ; and b.y means of a purge in fome cafes the (lolls have confided entirely of worms. DORSTENIA CONTRAJERVA. Radix. (Ed.) Contrayerva. Radix. (Dub. Lond.) Contrayerva. The root. Willd.g. 244. fp: 5. Tetrandia Monogynia. Nat.ord. Scabrida.. This plant is perennial, and grows in South America, and fome of the Caribbean iflands. The root is knotty, an inch or two long, and about half an inch thick, of a reddifh brown color externally, and pale within, long, rough, flender fibres (hoot out from all fides of it ^ and are gene- rally loaded with fmall round knots. It has a peculiar kind of aromatic fmell, and a fomewhat aftringent, warm, bitteriffi tafte, with a light and fweetifh kind ot acrimony, when long chewed ; the fibres have little tafte or fmell; the tuberous part, therefore, ffiould be alone chofen. This root contains fo much mucilage, that a decoaion of it will not pafs through the filter. Alcohcvl does not extraft half as much as water, but the fenfible qualities of the alcoholic ex- traa are ftronger. Neither of them are blackened by fulphate of iron. Contrayerva is a gentle ftimulant and diaphoretic, and is fome? times given in exanthematous difeafes, typhus, and dyfentery. Its dofe is about half a drachm. DULCAMARA. (Dub.) SeeSoLANUM. ELEMI. (Lond. Dub.) See Amyris. ENULA CAMPANA. (Lond. Dub.) See Inula. Part II.] Materia Medicd. 121 ERYNGIUM MARITIMUM. Eryngium. Radix. (Lond. Dub.) Eryngo. The root. Willd.g.518. fp. 6. Pentandria Monogynia.—Nat. ord. Uni* iellata This plant grows plentifully on fome of our fandy and grav- elly ffiores ; the roots are flender, and very long; of a pleafant fweetifh tafte, which, on chewing them for fome time, is follow- ed by a light degree of aromatic warmth and acrimony. They are accounted aperient aud diuretic, and have alfo been celebrated as aphrodifiac ; their virtues, however are too weak to admit them under the head of medicines. EUGENIA CARYOPHYLLATA. Caryopkyllus Aromaticus. Floris germen, et oleum eftts vola- tile. (Ed.) Caryophylla aromatica,tt oleum eorundem effentiale. (Dub.) Caryopkyllus aromatica. Pericarpium, immaturumet oleum ejus effentiale. (Lond.) The clove tree. The flower bud and its effential oil. Willd. g. 072. fp. 24. Icofandria Monogynia.-—Nat. ord. Hefi perideee. This is a beautiful tall tree, a native of the Molucca Iflands. The Dutch from the defireof monopolizingthe valuable fpice pro- duced by it, deftroyed all the trees except in Amboyna where it. is carefully cultivated. But their fcheme has been fruftrated, and the clove is now thriving in the Ifle of France and other pfaces. Every part of this tree is highly aromatic, but efpecially the Jeat- ftalk. Cloves are the flower buds, which are gathered in Oaober and November, before they open, and when they are ftill green, and which are expofed to fmoke tor fomfe days, and then dried in the fun. Cloves have fomewhat the form of a nail, confifting of a globu- lar head, formed of the four petals of the corolla, and four leaves of the calyx not yet expanded; but this part is often wanting, being eafily broken off; and a germen fituated below, neatly? round, but fomewhat narrower towards the bottom ; fcarcely ai* inch in length, and covered with another thicker calyx, divided above into four parts. Their color fhould be of a deep brown, their fmell ftrong, peculiar, and grateful ; their tafte acrid, aro- matic, and permanent. The beft cloves are alfo large, heavy, brittle, and when preffed with the nail, exude a little oil. When light, foft, wrinkled, dirty, pale, and without fmell or tafte, they are to be rejeaed. The Dutch, from whom we have this fpice, frequently mix it with cloves from which the oil has been diftilled. Thefe, though hi time they regain from the others a confiderable ffiare both of v< 222 Materia Mediea. [Part II. tafte and fmell, are eafily didinguiffiable by their weaker flavor and lighter color. The charaaeriftic conftituents of cloves are an effential oil, and a refinous matter, in which their acrimony principally refides. Cloves, confidered as medicines, are very hot ftimulating aro- matics, and poffefs in an eminent degree the general virtues of fubftances of this clafs. The effential oil of cloves is obtained by diftillation. It has a ftraw color, is tranfparent, and finks in water. It is alfo got from the Dutch, who coramonjy adulterate it with tinaure of cloves, which gives it a brown color, and renders its tafte more pungent and acrid,"' FERRUM, Iron is the moft common of all metals. It feems even to be a conftituent of organic fubftances, and is the only metal which when taken into the body, exerts no deleterous aaion upon it. The numerous ores of it which are found in every part of the glebe, may be reduced to the following genera. \. Native iron. Immenfe ifolated maffes of this have been found in Siberia and in South America. Their origin is ftill per- feaiy problematical. 2. Carburetted iron. Plumbago. 3 Sulphuretted iron. Pyrites. 4. Oxidizedt'iro». a. Lefs oxidized. , Magnetic iron ore ; color black or grey. b. More oxidized. Not magnetic ; color red or brown. c. Carbonated. V. Arfeniated. e. 'Tungftated. The properties of iron, when obtained from any of thefe ores by the ufual proceffes of-fufion, &c. have been already (ijo,.) defcrib- ed. As its mechanical divifion is extremely difficult, it is direaed to be kept in the (hops in the ftateof filings or wire, and the fcales of black oxide, which are found around the fmith's anvil. Soft malleable iron is the only kind fit tor internal ufe, as fteel and caft iron always contain impurities and often arfenic. The general virtues of, this metal, and the feveral preparations of it, are, to conftringe the fibres, to quicken the circulation, to promote the deficient fecretions in the remoter parts, and at the fame time to reprefs inordinate difcharges into the inteftinal tube. After the ufe of them, if they take effea, the pulfe is very fen- fibly raifed ; and 4he color of the face, though before pale, chan- ges to a florid red ; the alvine, urinary, and cuticular excretions, are increafed. Fetid eruaations, and the faeces voided ofa black •olor, are marks; pf their taking due effea. Part II.] Materia Medica. f iron. When iron is heated to rednefs in the fmith's forge, to render it more malleable, its furface becomes oxidized by the aaion of tlW atmofpheric air ; and as the oxide formed does not adhere to the iron, it is eafily feparated by percuflion on the anvil, and flies off in the ftate of fparks, which on cooling, conftitute the fcales of iron. In thefe the iron is oxilfczed to that degree in which it is foluble in acids, without the produaion of hydrogen gas ; there- fore when taken in the ftomach, they do not produce the diften- tion and flatulence oceafioned by the ufe of the filings. , Sulpha Ferri. , Ferrum vitridlatum. (Dub.).,- .Sulphate of iron! Greeflcvitriol. Copperas. '♦The fulphate of 'iron of commerce is commonly obtained by the*fpontaneous oxidizement of fulphuretted iron, and fubfequent ijixiviafion and cryftallization. It is never .pure, and often con- tains zinc or copper. The copper may be feparated by adding fome metallic iron to the folution, but we have no means of fepa- rating the zinc ; therefore we muft prepare it by diffolving iron in diluted fulphuric acid, in order to obtain it in a ftate of purity. Its cryftals are tranfparent rhomboidal prifms, of a fine green color. They are foluble in two parts of cold, and in lefs than their own weight of boiling water. They are infoluble in alcohol. They are compofed of Black oxide of iron, s81 />r> t. j -j r- . Water of compofition, 8 j> 3<$ Green hydro oxide of iron. . 26 Sulphuric acid. 38 Water of cryftallization. 100 Green fulphate of iron is decompofed by all the earths and al- kalies, and by thofe falts whofe bafe forms an infoluble com- pound with fulphuric acid. 11 is alfo decompofed by expofure to the air, efpecially when in folution, and by all fubftances which part readily with their oxigen. The oxide of iron abforbs oxy- gen, and paffes to the ftate of red oxide, which forlns a red ful- phate, poueffing properties very different from thofe of the green fulphate. Taken into the ftomach, the green fulphate is apt to excite pain in tht ftomach, and fpafms in the bowels, and in large dofes it .? Part II.] Materia Medica. S£5 caufes vomiting. In fmall dofes, however, of from one tp three grains, it is fometimes given as a tonic, aftringent, or anthelmintic. FERULA ASSA FOETIDA. Gummi refina. (Ed.) A fa fcetida. Gummi refina. (Lond. Dub.) Affa tcetida. A gum refin. Willd.g. ,539.fp. u.—Pentandria Digynia.—Nat. ord. Urn- be Hat a. The plant which furnifhes affa fcetida is perennial, and a native 6f Perfia. It has, however, borne fertile feeds in the open air in the Botannical Garden of Edinburgh. The gum refin is procured from the roots of plants which are at leaft tour years old. When the leaves begin to decay, the ftalk is twitted off, and the earth removed from about their large tapering roots. The top of the root is fometimes afterwards cut off tranfverfely ; and fortyeight hours afterwards the juice, Which has exuded, is fcraped off, and a fecond tranfverfe feaion is made. This operation is repeated until the root be entirely exhaufted of juice. After being fcrap- ed off, the juice is expofed to the fun to harden. It is. brought to us in large irregular maffes, compofed of vari- ous little ffiining lumps or grains, which are partly of a whitiffi color, partly reddifh, and partly of a violet hue. Thofe maffes are accounted the beft which are clear, of a pale reddifh color, and variegated with a great number of elegant white tears. This drug has a ftrong fetid fmell, fomewhat like that of gar- lic ; and a bitter, acrid, biting tafte. It lofes fome of its fmell and ftrength by keeping; a circumftance to be particularly re- garded in its exhibition. Affa fcetida contains more gum than refin, but its predominant Conftituent is effential oil. It is the moft powerful of all the fetid gums, and is,a moft val- uable remedy. It aas as a ftimulant, antifpafmodic, expeaorant, cmmenagogue and anthelmintic. Its action is quick and pene* trating. It is often fcrviceable, l.Tn croup. , ' . , . 2. In dyfpepfia, amenorrhcea and chlorofis. 3. In afthma, dyfpncea arid hyfteria. 4. In tympanites and worms. It is exhibited, I. In fubftance, in the form of pills; in dofes of from five to twenty grains, either alone, or «ombined with bitter ex- traas or purgatives. s. Diffolved in fome fimple diftilled water. 3. Diffolved in alcohol. 4. In the form of clvfter, to the extent of about two dracnms, Q ' 22§ Materia Medica. [Part II. FICUS CARICA. Fruclus. (Ed.) Carica. Fruclus. (Lond. Dub.) The figtree. The fruit. Polygamia Tricecia.—Nat. ord. Scabrida. This tree 'is probably a native of Afia, but grows plentifully in the fouth ot Europe. As the fruit is very pulpy, it is dried when it is to be preferved. To this country they are chiefly brought from the Levant. They confift almoft entirely of fugar and mucilage, and are therefore deraulceht. They are alfo ef- teemed by fome as fuppuratives ; and they are fometimes appli- ed by themfelves, heated as warm as they can eafily be borne, to promote the fuppuration of a phlegmon, particularly when fo {ituated that other cataplafrns cannot eafily be kept applied. FILIX tylAS, (Lond. Dub.) See Polypodium. FOENICULUM DULCE. (Lond. Dub.) See Anethum. FOENUM GR^ECUM. (Lond.) See Trigonella. FRAXINUS ORNUS. Succus concretus. (Ed.) Manna. (Lond. Dub.)' Manna afh. The concrete juice. Manna. Polygamia Diacia.—Nat. ord. Afcyroidea. Manna is obtained from other fpecies of fraxinus befides the ornus, and efpecially from the rotundifolia. It is principally colleaed in Calabria, Apulia and Sicily. In the warmeft fea- fon of the year, from the middle of June to the end of July, a clear juice exudes from the ftem and branches of thefe trees, which, when naturally concreted on the plants and fcraped off, is called Manna in the tear; but if allowed to exude on draws, or chips of wood fattened to the tree, it is called Canulated or flaky manna. The common or fat manna, is got by incifions made after the fponta- neous exudation is over, and is in larger maffes and ofa redder color. The beft Calabrian manna is in oblong, light, friable pieces or flakes, of a whitiffi.or pale yellow color, and fomewhat tranfparent. The inferior kinds are moift, unauous, and dark colored. Manna is faid to be fometimes counterfeited by a com- pofition of fugar and honey, mixed with a little fcammony; there is alfo a faaitious manna, which is white and dry, faid to be com- pofed of fugar, manna, and fome purgative ingredient, boiled to a proper confiftence ; this may be diftinguifhed by its weight, folid- ity, untranfparent whitenefs, and by its tafte, which is different from that of manna. Manna is a mild, agreeable laxative, and may be given with fafety to children and pregnant women j neverthelefs in fome par- ticular cojift.ituuon.s, it aefs very unkindly, producing flatulency Part II.] Materia Medka. "227 and diftention of the vifcera ; thefe inconveniences may be pre- vented by the addition of any grateful warm aromatic. Manna operates fo weakly as not to produce the full effea ofa cathartic, unlefs taken in large dofes ; and hence it is rarely given with this intention by itfelf. It may be commodiouflv' diffolved iu- the purg- ing mineral waters, or joined to the cathartic falts, fenna, rhu- barb, or the like. . FULIGO LIGNI COMBUSTI. (Dub.) Wood foot. This fubftance is inflammable, of a ffiining black color, a dif- agreeable fmell, and'an empyreumatic, bitter naufeous tafte. It varies fomewhat according to the' nature of the fubftance, and the ftrength of the fire employed in its produaion. But it con- fifts principally of charcoal, empireumatic oil, and acetous acid. It fometimes contains, ammonia, and the other alkalies and earths. Its medical properties are to be afcribed folely to the empynejunra- tic oil it contains, FUMARIA OFFICINALIS. Fumaria. Herba. (Dub.) Common fumitory* The plant. Diadelphia Hexandria.—Nat. ord. Lomentacea. This is a common annual weed in ffiady cultivated grounds. It is very juicy, ofa bitter tafte, without any remarkable fmell, The alleged medical effeas of this herb are, to ftrengthen the tone of the bowels, gently loofen the belly, and promote the uri- nary and other natural fecretions. It is principally recommend- ed in melancholic, fcorbutic, and cutaneous diforders. GALBANUM. (Lond. Dub.) SeeBuBON. GALLA. (Lond. Dub.) See O^uergus Cerris* GAMBOGIA. (Ed. Lond. Dub.) See Stalagmite. GENISTA. (Lond. Dub.) SeeSpARTiUM. GENTIANA LUTEA. Radix. (Ed.) Gentiana. Radix. (Lond. Dub.) Gentian. The root. Willd.g.512.fp. 1.—Pentandria Digynia.—Nat. ord. Rotacea. Gentian is a perennial plant, which grows upon the Alps^ Pyrennees, Appenines and other mountainous fituations in the temperate parts of Europe. The .roots .are long,, thick, externally of a brown color and wrinkjed ; infernally fpongy and ef a yellow 6olor, without anv gsr a - -228 Materia Medica. [Part It, remarkable fmell, but furpaffiug in bitternefs all other European vegetables. Alcohol diffolves only the bitter extraaive-, water both the extraftive and mucilage. Gentian pofTeffes the general virtues of bitters in an eminent degree, and it is totally devoid of aftringency. On dead animal matter it aas as an antifeptic, Taken into the ftomach, it proves a powerful tonic, and in Jarge dofes it evacuates the inteftines. It is ufeful in debility of the ftomach, in general debility, and in gout. Combined with an aftringent, it cures intermittents. Ex- ternally it rs-applied to putrid ulcers. It is rarely given in fubftance, becaufe the heat neceffary to be applied to render it puIvertXable is faid to injure its virtues. It is therefore exhibited in infufion, tinaure or extract, all of which will be noticed hereafter. GEOFFR^EA INERMIS. Cortex. (Ed.) Geoffroca. Cortex. (Dub.) Cab; ^ - bark tree. The bark. Diadgiphia Decandria.—Nat. ord. Papilionacea. The bark of this tree, which grows in the low favannahs of Ja- maica, is ot a grey color externally, but black and furrowed on the infide. The powder looks like jalap, but is not fo heavy. It has a mucilaginous and fweetifh tafte, and a difagreeable fmell. But its medical effects are much greater than its fenfible qualities would lead us to expe&. It is given in cafes of worms, in form of powder, decoaion, fyrup, and extraft. The decoaion is preferred; and is made by flowly boiling an ounce of the frefh dried bark in a quart of wa- ter, till it affume the color of Madeira wine. This fweetened is the fyrup; evaporated, it forms an extraa. It commonly pro- duces fome ficknefs and purging; fometimes violent effects, as vomiting, delirium and fever. Thefe laft are faid to be owing to an over dofe, or to drinking cold water ; and are relieved by the ufe of warm water, caftor oil, or a vegetable acid. It ffiould always be begun in fmall dofes; and when properly and cautiouf- ly adminiftered, it operates as a very powerful anthelmintic, particularly for the expulfion of the lumbrici, which are a very tcommon caufe of difeafe in the Weft India iflands ; and there it is very frequently employed. GINSENG. (Lond.) See Panax. GLYCYRRHIZA GLABRA. Radix. Extraclum. (Ed.) Glycyrrhiza. Radix. (Lond, Dub.) Liquorice. The root and the extract. Diadelphia Decandria.—Nat. ord. Papilionacea. Liquorice is a perennial plant, and a native^lff the fjuth of Europe, but it is cultivated in confiderable quantities in England Part II.] Materia Medica. 220 for medical purpofes; and the roots which are raifed in this coun- try, are preferred to thofe imported from abroad, which efiini. (Lond.) Lignum, Gummi refina. (Dub.) Guaiac. The wood, bark and gum refin. Willd.g. Stg.fp. 2.—Decandria Monogynia.—Nat. ord. Gtuu nales. This tree is a native of the Weft Indies', where it grows t© a middling fize. The wood is heavier than water, very hard, refi. nous, and of a greeniffi black color. Its tafle is bitteriffi, and when kindled it gives out a pleafant fmell. It is brought either in pieces, which are fometimes covered with a pale yellow albur- num, or already rafped, when by'divifion its color appears greeniffi, brown or yellow. The bark is thin, of an alh grey or blackiffi color, and apparently compofed of feveral lamh.ae. It js lefs refinous than the wood. The refin exudes fpontaneoufly in tears, but is principally obtained by fawing the wood into billets' about three feet long, which are then bored with an augre longi- tudinally. One end of thefe is laid upon a fire, fo that a calabafh may receive the melted refin, which runs through the hole as the wood burns. It may be alfo obtained by boiling the chips or fawings of the wood in water and muriate of foda. The refin fwims at the top, and may be fkimmed off. This refin has a brownifh yellow coior externally ; when held againft the light is tranfparent, breaks with a uniform fmooth ffiining fraaure, of a bluifh green color, pulverizable, powder of a white color, grad- ually becoming bluifh green, fufeable in a moderate heat, but not foftened by the heat of the fingers, foluble in alcohol, infoluble in water, without proper fmell or tafte, but when thrown on hot coals diffufing an agreeable odor, and when fwallowed in a ftate of mi- nute divifion, caufing an infufferable burning and prickling in the throat. It therefore is not a gummy refin, but a pure refin. It is fometimes adulterated with colophony or common refin, but the fraud is eafily deteaed by the fmell of turpentine which they emit when thrown on live coals. Taken internally, guaiac commonly excites a fenfe of warmth in the ftomach, a drynefs of the mouth, with thirft. It increafes the heat ot the body, and quickens the circulation. If the pa- tient be kept warm, it produces diaphorefis ; if expofed freely to the air, an increaW flow of urine. In large dofes it is purgative. Part II.] Materia Medica. 251 Guaiac is a ufeful remedy, i. In rheumatifm and gout. 9. In certain venereal fymptoms, as in foul indolent ulcers, and a thickened ftate of the ligaments or periofteum, re- maining after the body is reduced by a mercurial courfe. Guaiac will alfo fufpend the progrefs of fome of the fe- condary fymptoms, but it is totally incapable of eradicat- ing the difeafe. 3. In cutaneous difeafes. 4. In ozsena and fcrofulous affeaions of the membranes and ligaments. The wood is always exhibited in decoaion, from the refimfus nature of the aaive conftituent of this fubftance. This cannot be a very aaive preparation, and the menftruum is totally incapable of diffolving, though it may fufpend a little of the refin. Thede- co6tion of an ounce may be drunk in cupfuls in the courfe of a day. The refin may be exhibited, 1. In fubftance, either made into pills, or fufpended in wa- ter in the form of an emulfion. In this way from 1® to 30 grains of the refin may be taken in the day. %. Infolution; in alcohol. About half an ounce of the tinc- ture, with three ounces of water, is a fudorific dofe for an adult, if he attend to keeping hirnfelf warm. 3. Combined with an alkali, ■» GUMMI ARABICUM. (Dub.) See Mimosa. GUMMI TRAGACANTHA. (Dub.) See Astragalus, H^MATOXYLON CAMPECHIANUM. Lignum. (Ed.) Hamatoxylum. Lignum. (Lond. Dub.) Logwood tree. The wood. Willd.g. 830. fp. 1.—Decandria Monogynia.'—-Nat. ord. Lo- mentacea. This tree was introduced from the Honduras into Jamaica, where it is now very common. The wood is firm, heavy, and of a dark red color. Its tafte is aftringent, with a perceptible de- gree of fweetnefs. It is principally ufed as a dye wood, but alfo with confiderable advantage in medicine. Its extraa is a very powerful aftringent, combined with mucil- age and perhaps fugar ; and is, therefore, ufeful in obftinate diar- rhoeas, and in chronic dyfentery. HELLEBORASTER. See Hellebores Foetidus, £T4 23^ Materia Medica. [Part II, HF.LLEBORUS. Willd.g. 1089.—Polyandria Polygynia. Nat. ord. Multifiliquct. Sp. 2. Helleborus Niger. Radix. (Ed. Lond. Dub.) Melampodium. Black Hellebore. The root. This plant is perennial, and grows wild in the mountainous parts of Auftria, and on the Pyrennees and Appenines ; the ear- linefs of its flowers, which fometimes appear in December, has gained it a place in our gardens. The roots confift of a black furrowed roundiffi head, about the fize of a nutmeg, from which fhort articulated branches arife, fending out numerous corrugated fibres, about the thicknefs of a ftraw, from a fpan to afoot in length, deep, brown on the outfide, white, or yellowiffi white within, and of an acrid, naufeous and bitteriffi tafte, exciting a fenfe of heat and numbnefs in the tongue, and of a naufeous acrid fmell. Thefe fibres only are ufed in medicine, and the head and decayed parts are reje£ted. For the roots of the real black hellebore, the roots of the Adonis vei> nalis, Trollius Europaeus, Aaaea fpicata, Aftrantia major, Helle- borus viridis fcetidus, Veratrum album, and Aconitum neomon- tanum, are often fubftituted. The laft is a moft virulent poifoa, and may be diftinguifhed by its roots being fufiform, or nearly globular, fending/out numerous very brittle fibres, of a greyifh black or brown color, as thick as a man's finger, and repeatedly divided. But the furell way to avoid miftakes, is by the apothe- cary cultivating the plant itfelf in his own garden. In large dofes, hellebore is adraftie purgative ; in fmaller dofes it is diuretic, and emmenagogue. Its a£tive conftituent feems to / be of a volatile nature ; for it lofes its virtues by keeping, and water diftilled from it has an acrid tafte. It is principally ufed as a purgative in cafes of mania, melan- choly, coma, dropfy, worms and pfora, and as an emmenagogue. But its ufe requires very great caution, for its effeas are very un- certain, and affeaed by many circumftances. It is commonly exhibited in the form of extraa, although its attivity be much diffipated by the preparation. An infufion or tinaure certainly promife to be medicines ot more uniform powers. Willdenow fays that the black hellebore of the ancients js his fifth fpecies, the Helleborus orientalis. Sp. 6. Helleborus Foetidus. Helleborafter. Folium. (Lond.) Bears foot. The leaves. This fpecies is a native of England. It i perennial, and grows, in ffiady places, and under hedges. The leaves hr.ve an acrid, Litter, naufeous tafle, anduiapleafdnt find;, efpecially when they Part II.] Materia Medica. 233 are freffi. When dried, they are frequently given as a domeftic medicine to deftroy worms; but they muft be ufed fparingly be* ing fo violent in their operation that initances of their fatal ef- feas are recorded. HORDEUM DIST1CHON. Semen omni cortice nuddtum. (Ed.) Hordeum dijlichum. Semina. (Dub.)Hordeum. Semen. (Lond.) Barley. The feed. Pearl barley. Willd.g. 151.fp. 3. Triandria Dygynia.—Nat. ord. Gramina. Barley is an annual plant, cultivated in almoft every country of Europe. Linnaeus fays that it is a native of Tartary, but with- out adducing fufficient proof. Pearl barley is prepared by grinding off the hufk of rough bar- ley, and forming the grain into little round granules, which ap- pear ofa kind of pearly whitenefs. In this ftate barley confifts almoft folely of amylaceous matter, and when boiled forms an excellent article of nourifhment; while a decoaion of it, proper- ly acidulated, is one of the beft beverages in acute difeafes. HYDRARGYRUM. (Dub.) Hydrargyrus. (Lond. Ed.) Mercury. Quickfilver. The general, chemical, and phyfical properties of this metal, have been already (165) enumerated. We (hall now treat of it more minutely, as forming an important article in the Materia Medica. It is found, I. In its metallic ftate : a. Uncombincd. b. Alloyed with filver. c. Alloyed with copper. d. Combined with fulphur, (Cinnabar.) e. Combined with hydroguretted fulphur, (TEthiops mine- rale.) II. Oxidized : a. Combined with muriatic acid. b.-----------------fulphuric acid. There are confiderable mines of mercury in Hungary and in Spain ; and what is employed in England is principally import- ed from the former country. Mercury taken into the ftomach in its metallic ftate' has no ac- tion on the body, except what arifes from its weight or bulk. It is not poifonous as was vulgarly fuppofed, but perfeaiy inert. But in its various ftates of combination, iTproduces certain fen- fible effeas. It quickens the circulation, and increafesall the fe- 234 Materia Medica. [Part. II. cretions and excretions. According to circumftances, the habit of the body of the patient, the temperature in which he is kept, the nature of the preparation, and the quantity in which it is ex- hibited, its effeas are indeed various ; it fometimes increafes one fecretion more particularly, fometimes another, but its moft char- aaeriftic effea is the increafed flow of faliva, which it generally excites if given in fufficient quantity. Its particular Affeas, and means ot producing each of them, will be noticed hereafter. From many motives, both laudable and culpable, mercury has been tortured into a greater variety of forms than any other arti- cle ot the Materia Medica. Of thefe Swediaur has given a complete table in the late addition of his works on the venereal difeafe. It is too long for infertion in thi* place ; we fhall there- fore give a fyftematic view of thofe mercurial preparations only which enter at leaft one of the Britiffi Pharmacopoeias. Mercury is exhibited, I. Purified by diftillation. Hydrargyrum purificatum. (Dub. Lond.) II. Oxidized in a fmaller degree. a. By precipitation from its folution in nitrous acid, by am- monia. Oxidum hydrargyri cinereum. (Ed.) Pulvis hydrargyri-cinereus. (Dub.) b. By trituration: I. With unauous fubftances. Unguentum hydrargyri. (Ed.) ——---------------------fortius. (Lond. Dub.) 1 ■ -------=--------mitius. (Lond. Dub.) Emplaftruro ammoniaci cum hydrargyro. (Lond.) —----------- lithargyri cum hydrargyro. (Lond.) ■-------------hydrargyri. (Ed.) 2. With faccharine fubftances. Pilulas hydrargyri. (Lond. Dub. Ed.) 3. With carbonate of lime. Pulvis hydrargyri cum creta. (Lond.) III. Oxidized in a greater degree : 1. By the aaion of heat and air. Hydrargyrum calcinatum. (Lond. Dub.) a. By the aaion ot nitrous acid. Oxidum hydrargyri rubrum per oxidum nitricum. (Ed.) Hydrargyrum fub nitratum. (Dub.) Hydrargyria nitratus ruber. (Lond.) Unguentum oxidi hydrargyri rubri. (Ed.) IV. Oxidized and combined with acids : A. Oxidized in a fmaller degree, Part II.] Materia Medica. 235 1. With nitrous acid : Unguentum hydrargyri nitrati. (Lond. Dub. Ed.) 2. With fulph'uric acid : Subfulphas hydrargyri. (Ed.) Hydrargyrum fubvitriolatum. (Dub.) Hydrargyrus vitriolatus. (Lond-) g. With muriatic acid : a. By fublimation. Submurias hydrargyri. (Ed.) Hydrargyrum muriatum mite fublimatum. (Dub.) Calomelas. (Lond.) b. By precipitation. Submurias hydrargyri praecipitatus. (Ed.) Hydrargyrum muriatum mite praecipitatura. (Dub.) Hydrargyrus muriatus mitis. (Lond.) 4. With acetous acid : Acetis hydrargyri. (Ed.) Hydrargyrum acetatum. (Lond. Dub.) B. Oxidized in a greater degree. l. Muriate. ' Murias hydrargyri. (Ed.) Hydrargyrus muriatus. (Lond.). Hydrargyrum muriatum corrofive. (Dub.) 2. Submuriate with ammonia. Calx hydrargyri alba. (Lond.) V. Combined with fulphur : 1. By trituration. Sulphuretum hydrargyri nigrum. (Ed.) Hydrargyrum fulphuratum nigrum. (Lond. Dub.) 2. By fublimation. Hydrargyrum fulphuratum rubrum. (Lond. Dub.) Mercury, or fome of its preparations, is exhibited, 1. As an errhine. The fubfulphate ot mercury." 2. As a fialogogue. Mercury in almoft any form. 3. As a cathartic. The fubmuriate of Mercury, (calomel.] 4. As a diuretic. The oxides, the muriate, and the fubmu- riate, combined with other diuretics. 5. As a fudorific. Calomel conjoined with a fudorific reg- imen. 6. As an emmenagogue, 7. As an aftringent. Muriate of mercury. 8. As a ftimulant. Muriate of mercury. 9. As an antifpafmodic. jo. As an anthelmintic. With fome of thefe views, mercury is frequently exhibited, 1. In febrile difeafes ; in obftinate agues. 236 Materia Medica. [Part U. 2. In inflammatory difeafes ; in indolent and chronic inflam- mations, efpecially of the glandular vifcera, as the liver, fpleen, &c. *. In exanthematous difeafes ; variola. 4. In profluvia ; in dyfentery, 5. In fpafmodic difieafes; tetanus, trifmus, hydrophobia, &c. 6. In cacheaic difeafes; anafarca, afcites, hydrothorax, hy- drocephalus, &c. 7. In impetigines; fcrofula, fyphilis, lepra, iaerus, &c. 8. In local difeafes ; in caligo corneae, amaurofis, gonor- rhoea, obftipatio, amenorrhcca fuppreffionis, tumors of various kinds, herpes, tinea, pfora, &c. Mercury occafionally attacks' the bowels, and caufes violent purging, even of blood. This effea is remedied by intermitting the ufe^of the medicine, and by exhibiting opium. At other times it 'is fuddenly determined to the mouth, and produces inflammation, ulceration, and an exceffive flow of faliva. In this cafe, too, the ufe of the mercury muft bedifcontinued for a time ; while, according to Mr. Pearfon's advice, the patient ffiould be freely expofed to a dry cold air, with the occafional ufe of cathartics, Peruvian bark, and mineral acids, and the affiduous application of aftringent gargles. On the other hand, the fudden fuppreffion of ptyaiifm isnot without danger. It is moft frequent- ly caufed by cold liquids being taken into the ftomach, or expo- fure to cold and moifture, while under the influence of mercury. The danger is to be obviated by the quick introduaion of mercury, fo as to affea the gums, with the occafional ufe of the warm bath. Sometimes alfo a morbid condition of the fyftem occurs during a mercurial courfe, and which tends to a fatal iffue. Mr. Pearfon has termed it Erethifmus. It is charaaerized by great depreffions of ftrength ; a fenfe of anxiety about the praecordia ; frequent figh- ing ; trembling, partial or univerfal ; a fmall, quick pulfs; fome- times vomiting ; a pale contraaed countenance ; a lenfe of cold- nefs, while the tongue is feldom furred, or the vital or natural funaionsmuch difordered. In this ftate a fudden or violent ex- ertion of mufcular power will fometimes prove fatal. To pre- vent dangerous confequences, the mercury muft be difcontinued, whatever may be the ftage, extent, or violence of the difeafe for which it has been exhibited, and the patient muft expofe himfelf freely to a dry and cool air, in fuch a manner as ffiall be attended with the leaft fatigue ; and in the cqurfe of ten or fourteen days, he will fometimes be fo far recovered that he may fafely refume- the ufe of mercury. HYOSCYAMUS NIGER. Herba. Semen. (Ed.) Hyofcyamus. Herba. Semen. (Dub.) Black henbane. The herb and feeds. I^art II.] Materia Medical 231 Willi, g. 378.7^. 1.—Pentandria Monogynia.—Nat. ord. Sola- tia cea. H e N b an e is a biennial plant, which grows in great abundance in moft parts of Britain. The fmell of the hyofcyamus is ftrong and peculiar ; and the leaves when bruifed emit fomewhat of the odour of tobacco. This fmell is ftill ftronger when the leaves are burnt ; and on burning they fparkle with a deflagration fomewhat refembling that of ni- tre ; but to the tafte they (hew no evident faline impregnation. When chewed, they are infipid, mild, and mucilaginous ; yet when taken to any great extent, they produce the moft alarming effeas. They give the appearances of intoxication, attended with wild delirium, remarkable dilatation of the pupils of the eyes, and convulfions. It often produces fweat, and fometimes an eruption of puftules over the furface, and generally found fleep, fucceeded by ferenity of mind, and recruited vigor of the body ; but like the other narcotics, inftead of thefe, it fometimes gives rife to vertigo, headach, and general uneafinefs. With particular indi- viduals it occafions vomiting, colic pains, a copious flow of urirfe. and fometimes purging. Upon the whole, like opium, it is a powerful anodyne ; and like cicuta, it is free from any conftipat- ing effea, having rather a tendency to move the belly. From thefe effeas, it is not furprifing that hyofcyamus fhould have been introduced into the practice of medicine ; and accord- ingly, it appears to have been ufed both externally and internally for a variety of purpofes. Several different fpecies ot the hyo- fcyamus were formerly employed, as appears from the writings of Diofcorides and others. Celfus, in particular, was very fond of this medicine ; he ufed it externally as a collyrium in cafes of ophthalmia ; he empolyed it topically for allaying the pain ot (oothach ; and he gave it internally, both with the view of miti- gating other pains, and of producing quiet fleep. For a confiderable length of time, however, hyofcyamus fell aK moft into difufe ; but the employment of it has of late been reviv- ed by Dr. Stork of Vienna ; and it has been ufed both by him, and by many other praaitioners in thofe cafes where an anodyne is requifite, and where an objeaion occurs to the ufe of opium. It is employed tor refolving fwelling, and allaying pain in cafes of fcirrhus, under the form of cataplafm of the leaves, or ofa plafler made from the oil of the feeds and power of the herb, With wax, turpentine, and other articles; or of ointment made of the powder of the leaves with hogs lard. In open ulcers, the powder of the leaves, fprinkled on the part, has often a good eflVa. ' An extraa from the leaves, or from the feeds, is the form in which it is given internally ; but contrary to what happens with cicuta, the former appears to be the moft powerful. This extra& has bren given with advantage in a variety of nervous affeaions. £38 Materia Medica. [Part It. as mania, melancholia, epilepfy, hyfteria, &c.; in glandular fwell- ings, in obftiriate ulcerations ; end in every cafe where it is nec- effary either lb allay inordinate aaion, or mitigate pain. In ac- compliffiing thefe ends, it is often no lefis ufeful than opium ; and it frequently fucceeds where opium produces very difagreeable effeas. The dofe of this extraa muft be accommodated to the circumftances of the cafe and of the patient ; and it has been in- creafed from half a grain to half a drachm in the day ; for like opium, its influence is very much diniiniffied by habit. HYPERICUM PERFORATUM. Hypericum. Flos. (Lond.) Common St. John's wort. The flower. Polyadelpkia Polyandria.—Nat. ord. Afcyroidea. •This plant is perennial,and grows wild in woods and unculti- vated places in Britain. Its tafte is rough and bitteriffi, and its fmell difagreeable. It abounds with an effential oil, which is contained in fmall veficles in the growing plant. Thefe vefieles, when viewed, by holding the plant between the eye and the light, referable perforations ; and the effential oil itfelf may be feparat- ed in confiderable quantity by diftillation. The flowering tops tinge expreffed oils of a red color, which very few vegetable fub- ftances do. HYSSOPUS OFFICINALIS. Herba. (Ed.) Hyffopus. . Folia. (Dub.) Hyffop. The herb. Willd.g. iog6.fp. i.—Didynamia Gymnofpermia.—Nat. ord. Verticillata. Hyssop is a perennial herb, which grows wild in Germany. The leaves of hyffop have an aromatic fmell, and a warm pung- ent tafte. Befides the general virtues of aromatics, they were formerly recommended in humoral afthmas, coughs, and other diforders of the breaft and lungs, and were faid to promote expec- toration. ICHTHYOCOLLA. (Lond. Dub.) See Accipenser. INULA HELENIUM. Enula campana. Radix. (Dub. Lond.) Elecampane. The root. Syngenefia Superflua.—Compofita radiata. This is a very large downy perennial plant, fometimes found wild in moift rich foils. The root, efpecially when dry, has an agreeable aromatic fmell ; its tafte, on firft chewing, is glutinous, and a* it were fomewhat rancid ; in a little time it difcovers an Part. II.] Materia Medica. 239 aromatic bitternefs, which by degrees becomes confiderably acrid and pungent. Its predominant conftituents are effential oil, mucilage, and a little bitter extraaive ; and it is therefore a gently ftimulating medicine, nearly fimilar in its aaion to angelica. The extraa is merely a flight bitter, as the effential oil is totally diffipated inth« preparation. IPECACUANHA. (Lond. Dub. Ed.) See Cephaelis. IRIS. Willi, g. 97. Triandria Monogynia.—Nat. ord. Enfata, Sp. 7. Iris Florektina. Radix. (Ed.) Iris. Radix. (Lond.) Florentine Oris. The root. This is a perennial plant, a native of the fouth of Europe, The dried roots are imported from Italy. They are white flat- tiffi, knotty, and have a very flightly bitter tafte, and an agree- able fmell, refembling that of violets. They are only ufed as a perfume. Sp. 24. Iris Pseudacorus. Iris. Radix. (Dub.) Water flag. The root. This plant is perennial, and grows in great abundance by the brinks of rivers, and in other watery places : The root has an ac- rid tafte ; and when freffi, is ftrongly cathartic. Tbe expreffed juice, given to the quantity of fixty or eighty drops every hour or two, and occafionally increafed, has been productive of very co- pious evacuations, after jalap, gamboge, and other ftrong purga- tives had proved ineffeaual ; and it is in this form only that it is ufed ; for by drying, it entirely lofes its purgative effeas. We have here another proof of the neceffity of denominating the officinal vegetables by their fyftematic names ; for in Eng- land, Radix Iridis is a pleafant perfume, in Ireland a draftic purgative ; and as confultations are not unfrequently fent from the one country to the other, ignorance of this circumftance might give rife to unpleafant confequences. ISIS NOBILIS. Ctrallium Rubrum. (Lond.) Red coral. Tn 1 s is the axis of a zoophyte of the order of ceratophyta. It is found only in the Mediterranean Sea, and the fentient fleffi is rubbed off by means of pumice ftone. The coral thus prepared is «f a fcarlet or pale red color, and fufceptible of a high poliffi. 240 Materia Medica. [Part II. As an article in medicine, it is to be regarded merely as an indu- rated carbonate of lime. JALAPA. (Dub.) JALAPIUM. (Lend.) See Convol- vulus. JUGLANS REGIA. Juglans. Fruclus Immaturus. (Lond.) The walnut tree. The unripe fruit. Monoecia Polyandria.—Nat. ord. Amenlacea. This beautiful tree, although.a native of Perfia, grows to a very large fize, and produces ripe fruit in moft parts of England. The fruit eonfifts ofa thick, fleffiy, green, fmooth rind, which in- clofes the proper nut. When unripe, they have a peculiar fmell, and a bitteriffi aftringent tafte. They have been fuppofed to pof- fefs tonic and anthelmintic virtues. The green rind has been cel- ebrated as a powerful antivenereal remedy ; but it poffeffes no real antifyphilitic virtues, although it forms a very ufeful addi- tion to the compound decoaion ot farfaparilla, where pains of the limbs and indurations of the membranes remain after the venere- al difeafe has been cured by mercury, and in many of thofe cuta- neous difeafes which are attended with aridity of the fkin. A de- coaion of the green rind has alfo been recommended as a ufeful application to old ulcers. JUNIPERUS. Dioecia Monadelphia.—Nat. ord. Coniferd. Sp. Juniperus Communis. Bacca. (Ed.) Juniperus. Bacca, Cacumen. (L ond.) Bacca. (Dub.) Juniper. The berries and tops. This is an ever green ffirub, growing on heaths and hilly grounds in all parts of Europe; the berries are brought fromi Holland and from Italy. The Italian berries are in general reck- oned the beft. Juniper berries have a ftrong not difagreeable fmell, and a warm pungent fweet tafte, which if they are long chewed, or previoufly well bruifed, is followed by a bitteriffi one*. Their predominant conftituents are effential oil, and a fweet mucilaginous matter. To the former of thefe they are indebted for their ftimulating, carminative, diaphoretic, and diuretic pro- perties. They are moft commonly ufed in the form of infufion, as a diuretic drink in dropfy. The effential oil may be feparated by diftillation. It poffeffes the fame properties in a higher [de- gree, and imparts them to ardent fpirits. The peculiar flavor, and well known diuretic efftas of Hollands, are owing to the oil of juniper. The decoaion and extraa are very inert preparations. Part II.] Materia Medica'. 241 Every part of the plant contains the fame effential oil; there- fore an infufion of the tops is likewife diuretic. The wood, alfo, was formerly officinal. In warm countries a refin exudes from the juniper tree. It is called fandarac, and is often mixed with maftich. Sp. Juniperus Lycia. Gummirefina. (Ed.) Olibanum. Gummi refina. (Lond. Dub.) Ohbanum. A gum refin. Olibanum is principally colleaed in Arabia, and brought from Mecca to Cairo, from whence it is imported into Europe. It con- fifts of tranfparent brittle grains of different fizes, not larger than a chefnut, of a red or yellow color, having little tafte^ and a pe- culiar aromatic fmell. It is entirely foluble in alcohol, forms a milky fluid when triturated with water, is not fufible, but in- flammable, and burns with an agreeable fmell. It is the frankin- cenfe of the ancients ; and the diffufion of its vapor around the altar ftill forms part of the ceremonies of the Greek and Roman Catholic churches. Sp. Juniperus Sabin a. Folia. (Ed.) Sabina. Folium. (Lond. Dub.) Savine. The leaf. This is an evergreen ffirub, a native1 of Siberia and Tartary, but not unfrequent in our gardens. The leaves have a bitter, acrid, biting tafte, and a ftrong difagreeable fmell ; diftilled with water, they yield an effential oil, in confiderable quantity. Savine is a warm ftimulating medicine, capable of producing diaphorefis, and increafing all the fecretions, but apt to excite bae- morrhagyj efpecially from the uterus. It is alfo recommended as an anthelmintic, and faid to be very efficient in the cure of the gout. Internally, a conferve of the freffi leaves is exhibited in dofes of from half a drachm to a drachm. Externally, the leaves are applied in the form of powder or in- fufion, to warts, carious bones, and old ulcers ; and in cafes of gangrene, pfora, and tinea. The effential oil is a very aaive re- medy. K^EMPFERIA &OTUNDA. Zedoaria. Radix. (Lond.) Round Zedoary. The root. WiUd. g. 12. fp. 2. Monandria Monogynia.—Nat. ord, Scit-a* tninea. This is a perennial plant, a natir^ of India. The roots are about an inch long, fomewhat rough on the furface, and often ter- minate in a point. They correfpond in fenfible qualities with the root* of the amomum zedoaria, but are not fo ftrong, By 242 Materia Medica. [Part 11. fome, indeed, they are fuppofed to be produced from the fame plant, and that the round zedoary is the upper, and the long ze- doary the under part of the root. KINO. Gummi refina. (Ed.) Refina. (Lond. Dub.) Gummi rubrum afiringens Gambienfe. Kino is brought to us from Africa, in amorphous pieces of va- rious fizes, to which the leaves of foma arundinaceous plant are often found adhering on tbe outfide. It is of a dark red color, hard, but fo brittle that it may be eafily rubbed to powder be- tween the fingers. Its fraaure is ffiining, and its texture often cellular. It has no fmell; when chewed it firft crackles between the teeth, then fticks to them, and is afterwards diffolved in the faliva, to which it gives .a reddifh black color. Its tafte is then perceived to be very aftringent, with a flight degree of fubfequent fweetnefs. It does not melt, and it burns with difficulty. It is very foluble both in water and in alcohol. The folutions are col- ored and tranfparent, ftrike an intenfely black color with ful- phate of iron, and form a white tenacious precipitate in a folution of ifinglafs. Its powder has a deep red color. From its folubility in water, it is evident that the London and Dublin Colleges err in denominating it a refin ; and we appre- hend that the Edinburgh College is not correa in calling it gum. , refin. The exaa nature of the gum refins is not perfeaiy under- ftood, but they feem in general to poffefs the following properties : Their fmell is often powerful, and their tafte never aftringent; they are either fufible, or foftened by heat, and burn readily ; they are partially foluble in alcohol and in water ; their watery folu- tion is opaque ; their alcoholic folution, on the contrary, is tranf- parent, but it is decompofed, and rendered milky, by mixing it with water, although there is no precipitation, or it takes place very flowly. Thefe folutions neither ftrike a black color with fulphate of iron, nor precipitate gelatine. On diftillation they afford effential oil. The gum refins all derive their origin from the natural juices,of the vegetables which afford them. They ei- ther exude fpontaneoufly from them, by burfting the veffels in which they are contained, or flow from incifions made intention- ally into them, and afterwards harden by expofure to the fun and air. They therefore, generally have a rounded form, whence they are often called Tears ; and their fraaure is compaa, and never cellular. From the total diffimilarity of charaaer, therefore, it appears evident to us, that this is not a gum refin; but we will venture a ftep farther, and fay that it is an aftringent extraa, obtained by decoaion and evaporation. We ground this opinion upon the co- incidence of the chemical properties of kino, with thofe of other aftringent extraas; upon the faft, that part of the kino of com- 4 Part II.] Materia Medica. 243 merce, not diftinguifhable from the African kino, is imported from Jamaica, and is known to be the extraa of an aftringent bark ; upon the very finking refemblance of this in every partic- ular with the extract of Swietenia febrifuga, fent by Dr. Rox- burgh from the Eaft Indies ; and upon the cellular texture of kino, which it could only acquire by the aaion of heat. All thefe proofs, however ftrong, would be overturned, if Dr. Fothergill's account of the origin of kino, which has been adopted by all the writers on materia medica fince his time, were correct. But there is no evidence whatever, that the gum dragon, mentioned by Moor as obtained by incifions made into the pau de fangue, is the fame with kino ; while, on the contrary, the very imperfea de- fcription he gives of his gum dragon, renders it almoft certain that it is not kino. Kino, therefore, in our opinion, ffiould be confidered as an ex- traa, from the probable manner of its preparation. In its chemi- cal properties, it is almoft pure tannin (260) and in its medical properties, it is a fimple aftringent. It is a powerful remedy in obftinate chronic diarrhoeas and dy- senteries ; in all paffive haemorrhagies, efpecially from the uterus ; in fluor albus ; and in difeafes arifing from laxity of the folids. It is exhibited internally, in dofes of from ten to thirty grains, in fubftance, or diffolved in diluted alcohol. Externally, it is applied as a ftyptic, to check haemorrhagies from wounds or ulcers, and to diminifh the difcharge of fanious or ichorous matter from ill conditioned ulcers. LACTUCA VIROSA. Folio. (Ed.) Strong fcented or wild lettuce. The leaves. Syngenefia aqualis.—Nat. ord. Compofitafemiflofculofiz. This plant is biennial, and grows wild on rubbiffi and rough banks, in many places in this country. It fmells ftrongly of opium, and refembles it in fome of its ef- feas ; and its narcotic power, like that of the poppy heads, re- fides in its milky juice. An extraa, prepared from the expreff- ed juice of the leaves of the plant, gathered when in flower, is recommended in fmall dofes in dropfy. In dropfies of long (land- ing, proceeding from vifceral obftruaions, it has been given to the extent of half an ounce a day. It is faid to agree with the ftomach, to quench thirft, to be gently laxative, powerfully diu- retic, and fomewhat diaphoretic. Plentiful dilution is allowed during its operation. Dr. Collin of Vienna afferts, that out of twen- tyfour dropfical patients, all but one were cured by this medicine. LADANUM. (Lond.) See Cistus. LAPIS CALAMINARIS. (Dub.) See Zincum. (£S-2 244 Materia Medica. [Part. II, LAURUS. Willd. g. 798. Enneandria Monogynia.—Nat. ord. Oltracea. Sp. 1. Laurus Cinnamomum. Cortex. (Ed.) Cinnamomum. Cortex et ejus oleum effentiale. (Lond. Dyk.) The cinnamon tree. The bark and its effential oil. This beautiful and valuable tree is native in Ceylon, where it was guarded with unremitting jealoufy by the Dutch, Tthat they Blight monopolize the commerce of its produaions. They failed,, however, in the attempt ; and cinnamon trees are found, not only in other parts of the Eaft Indies, but alfo in Jamaica, and other iflands of the Weft Indies. Cinnamon is the inner bark of this tree. It is of a reddifh co- lor, light, very thin, rolled up in long quills of a fragrant de- lightful, fmell, and an aromatic pungent tafte, with fome aftrin- gency. Its fra&ure is fplintery. The Dutch were accufed of deteriorating their cinnamon by mixing it with a proportion of real cinnamon, but which had been deprived of its effential oil by dif- tillation. This fraud could only be deteaed by the weaker fmell and tafte. It is alfo often mixed with caffia bark. This laft is eafily diftinguifhable by its breaking over fmooth, and by its flimy mucilaginous tafte, without any thing of the roughnefs of the true cinnamon. Cinnamon is a very elegant and ufeful aro- matic, more grateful both to the palate and ftomach than moft other fubftances ot this clafs. Like other aromatics, its effeas are flimulating, heating, fto- machic, carminative, and tonic ; but it is rather ufed as an aajunft to other remedies, than as a remedy itfelf. The effential oil of cinnamon has a whitifh yellow color, a pungent burning tafte, and the peculiar fine flavor of cinnamon in a very great degree. It fhould fink in water, and be entirely fol- uble in alcohol. It is principally prepared in Ceylon. It is one of the moft powerful ftimulants we poffefs, and is- fometimes ufed as a cordial in cramps of the ftomach and in fyn- cope ; or as a ftimulant in paralyfis of the tongue, or to deaden the nerve in toothach. But it is principally ufed as an aromatic, to cover the lefs agreeable tafte of other drugs. Sp.2. Laurus Cassia. Cortex. Flores nondumexplicitif Ed.) Caffia Lignea. Cortex. (Dub.) The cafBa tree. The bark and flower buds gathered before they open. This tree is very fimilar to the former. The bark, which is imported from different parts of the Eaft Indies and from China, has a very exaa refemblance to the cinnamon. It is diftinguifh- able from the Qinnamojj» by being of a thicker and coarfer ap- Part II.] Materia Medica- 245 pearance, and by its breaking ffiort and fmooth, while the cinna- mon breaks fibrous and ffi-very. It refembles cinnamon ftill more exaaiy in its aromatic flavor than in its external appearance, and feems only to differ from it in being fomewhat weaker, in abounding more with a mucilagin- ous matter, and in being lefs aftringent. Caffia buds are the flower buds which are gathered and dried before they expand. They have the appearance of a nail, con- fiftingof a round head, about the fize of a peppercorn, furround- ed with the imperfea hexangular corolla, which gradually termin- ates in a point. They have a brown color, and the fmell and tafte of cinnamon. Both the bark and buds of caffia poffefs the fame properties with cinnamon, though in an inferior degree. * The bark is very frequently, and fometimes unintentionally fubftituted for the more expenfive cinnamon ; and the produas obtained from caffia bark and buds by diftillation, are in no re- fpea inferior to thofe prepared from cinnamon. S/i. 3. LaurusCamphora. Campkora. (Ed.) Camphora. (Lond.) Refina. (Dub.) Camphor tree. Camphor. The camphor laurel grows in great abundance, and to a very confiderable fize, in the forefts of Japan. It is not uncommon in green houfes in England. Every part of the tree fmells ftrongly of camphor, which is obtained from the trunk, tranches, and root by diftillation. They are cut down into fmall pieces, and put into a ftill with a quantity of water. After the water has been kept boiling forty eight hours, the camphor is found adhering to the ftraw with which the head of the ftill is lined. In this ftate it is imported by the Dutch, and is called crude camphor. It is very impure, confifting of fmall brownifh or dirty grey grains, mixed with ftraw, wood, hair, and other impurities. From thefe it is purified in Holland, by a lecond fublimation in glafs veffels ; being previoufly mixed with quicklime, to combine with, and prevent any empyreumatic oil with which it may be contaminat- ed from fubliming, while the camphor concretes in the upper part of the veffel into cakes, convex on the one fide, and concave on the other, about two or three inches thick, thinner at the edges, and generally perforated in the middle. Pure camphor is lighter than water, very white, pellucid, fome- what unauous to the touch, brittle, yet tough and elaftic, fo as to be fcarcely pulverizable ; ffiining in its fraaure, and cryftalline in its texture ; of a bitteriffi, aromatic pungent tafte, yet accom- panied with a fenfe of coolnefs ; of a ftrong and very penetrating fmell ; very volatile, inflammable, burning entirely away with- out leaving any coal or afhes; capable of combining with the P"3 \ 246 Materia Medica. Part II.] fixed and volatile oils, refins and balfams ; foluble in rJcohol, ether, and the concentrated fulphuric, nitric, and acetic acids ; feparable from thefe alcoholic and acid folutions by water, infolu- ble in water, alkalies, and the weaker acids; decompofable by heat ; when mixed with alumina being converted into an effential oil and charcoal, and by treating it with nitric acid, which acidi- fies it, producing camphoric acid. But the produaion of camphor is not confined to the laurus camphora, although it furnifhes almoft all the camphor of com- merce ; it is found in very great purity in the interftices among the woody fibres of an unknown tree in Borneo ; it is alfo con- tained in the roots of the laurus cinnamomum and caffia, Alpi- nia galanga, amomum zedoaria, &c.; in the feeds of the amo- naum cardamomum, piper cubeba, &c. ; and in many indigenous plants, as in the thymus ferpyllum and vulgaris, juniperus com- munis, rofmarinus officinalis, falvia officinalis, mentha piperita, &:c. and may be feparated from the effential oils of rofemary, la- vender, marjoram and fage. It is therefore now univerfally con- fidered as a peculiar principle of vegetables, and notasarcfin, as flatedby the Dublin College. Camphor is a very aaive fubftance when taken into the ftom- ach. It increafes the heat of the body confiderably, and gives a tendency to diaphorefis, but without quickening the pulfe. At firft it raifes the fpirits, but produces a fubfequent depreffion; and it facilitates voluntary motion. In exccffive dofes it caufes fyn- cope, anxiety, retchings, convulfions, and delirium. Thefe vio- lent effeas of camphor are moft effeaually counteraaed by opium, In a morbid ftate of the body, camphor allays inordinate aaions. When the pulfe is hard and contraaed, it renders it fuller and fofter. It removes fpafms, and flitting pains arifing from fpafms ; and in delirium, when opium fails of procuring fleep, camphor will often fucceed. It is alfo faid to correa the bad effects of opium, mezereon, cantharides, and the draftic purgatives and diu- retics. The moft general indication for the ufe of camphor, is the lan- guor or oppreffion of the vis vita. It may therefore be given with advantage. I. In all febrile difeafes of the typhoid type, efpecially when attended with delirium. 2. In inflammations with typhoid fever, as in fome cafes of pe- ripneumonia and rheumatifm. 3. In eruptive difeafes, to favor the eruption, or to bring it back to the fkin, if from any caufe it has fuddeniy receded, as in fmallpox, meafles, &c. 4. In many fpafmodic difeafes, efpecially mania, melancholy, epilepfy, hyfteria, chorea, hiccough, &c. Part II.] - Materia Medica. 247 5. In indolent local inflammations, not depending upon an in- ternal caufe, to excite aaion in the part. As from its great lightnefs it is apt to fwim upon the contents of the ftomach, and to occafion pain at its upper orifice, it is ne- ceffary that it be always exhibited in a ftate of minute divifion. In order to reduce it to powder, it muft be previoufly moiftened with a little alcohol. It may then be given, 1. In powder, with fugar, magnefia, and nitrate of potafs. 2. In pills, with the fetid gums and mucilage. 3. In folution, in alcohol, oil, or acetic acid. 4. Sufpended in the form of an emulfion, by means of muci- lage, fugar, yolk of egg, almonds, vinegar, &c. Internally it may be given in fmall dofes, of from one to five grains, repeated at ffiort intervals, as its effeefs are very tranfient, or in large dofes, not under twenty grains. Sp. 10. Laurus Nobilis. Folia. Baccx. Bate drum oleum fixum. (Ed.) Laurus. Folium. Bacca. (Lond.) Bay tree. The leaves, berries, and expreffed oil of the berries'. This tree is a native of the fouth of Europe, but bears the winters of this climate perfeaiy well. Both leaves and berries contain a confiderable quantity of effential oil, which renders them aromatic, ftimulating fubftances. The berries are generally brought from the Mediterranean, and are more pungent than the kaves. In Spain and Italy a confid- erable quantity of oil is obtained by expreffion trom the freffi ber- ries. It has a green color, and ftrong aromatic tafte and fmefh As it therefore is not a fixed oil, but a mixture of fixed and effen- tial oil, and as its peculiar properties depend entirely on the pre- fence of the fatter, it is incorreaiy ftated to be a fixed oil by the Edinburgh College. It ffiould rather have been denominated, from the mibde of its preparation, an expreffed oil. It is only ufed externally as a ftimulant. Sp. 34. Laurus Sassafras. Lignum, radix,ejusque cortex. (Ed.) Saffafras. Lignum, radix, ejusque cortex. (Lond.) Lignum radix eorunique cortex. (Dub.) Saffafras. The wood, root and bark. This tree is a native of North America, and is cultivated in Jamaica. It is the root which is commonly employed. It is brought to us in long branched pieces. It is foft, light, and of a fpongy texture; of a rufty white color;, of a.ftrong, pleafant fmell, refembling that of fennel ; and a fweetifh aromatic fub- acrid tafte. The bark is rough,, of a brown afh color on the out- fit 4 248 Materia Medica. Part. II.] fide, and ferrugineous color within ; fpongy and divifible into layers, and of a ftronger tafte and fmell than the wood. Saffafras contains much effential oil, and is therefore a gently ftimulating, heating, fudorific and diuretic remedy. It is beft given in infufion, The decoaion and extraa are mere bitters, as the oil is diffipated by the preparation. The effential oil may be obtained feparate by diftillation. It is ofa whitiffi, yellow color, and finks in water. It is highly ftim- ulating and heating, and muft be given only in very fmall dofes. LAVANDULA SPICA. Spicaflorentes. (Ed.) Lavandula. Flos. (Lond.) Lavandula. Flores. (Dub.) Lavender. The flowering fpikes. Willd.g. 1099. fp. 1. Didynamia Gymnofpermia.—Nat. ord. Verticillata. Lavender is a well known fmall, ffirubby, perennial plant, a native of the fouth of Europe, but frequently cultivated in our gardens for the fake of its perfume. There are two varieties.__ The flowers of both have a fragrant agreeable fmell, and a warm, pungent, bitteriffi tafte; the broad leaved fort \& the ftrongeft in both refpeas, and yields in diftillation thrice as much effential oil as the other ; its oil is alfo hotter and fpecif\cally heavier ; hence, in the fouthern parts of France, where both kinds grow wild, this only is ufed for the diftillajion of what is called Oil of Spike. The narrow leaved is the fort commonly met with in our gardens Lavender is a warm ftimulating aromatic. It is principally uferi as a perfume. LEONTODQN TARAXACUM. Herba. Radix. (Ed.) Taraxacum. Radix. Herba. (Lond.) Radix. Folia. fD.ub.) Dandelion. The root and leaves. Syngenefia AZqualis.—Nat. ord. Compcfitafemifipfculofaf This perennial plant is very common in grafs fielo> and un- cultivated places. The whole plant contains a bitter, milky juice, which, however, is moft abundant in the roots before the flower ftem (hoots. The bitternefs is deftroyed by drying, and, therefore, the recent roots ©nly ffiould be ufed. Its vulgar name Pifs a bed, (hows a popular belief of its poffeffing diuretic prop- erties ; and it was lately a very faffiionable remedy in Germany, and given in the form of an expreffed juice or decoaion, or ex- traa prepared from either of them, To us it feems merely a mucilaginous bitter. LIL1UM CANDIDUM. Lihum album. Radix. (Dub.) The wfiite lily. The root, Part II.] Materia Medica. 219 Willd. g. 127. fp. 3. Hexandria Monogynia.—Nat. ord. Liliacece, The while lily is a perennial, bulbous rooted plant, a native of the fouth of Europe, and cultivated in our gardens for the beauty of its flowers. The mucilaginous root is fometimes ufed as a poultice; but it poffeffes no advantage over the poultices formed of any vegetable farina. LIMON. (Lond. Dub.) See Citrus.. LINUM. Willd. g. 590. Pentandria Pentagynia.----Nat. ord. Gruinales. Sp. 1. Linum Usitatissimum. Semen, ejufque oleum fix- um. (Ed.) Linum. Semen. (Lond. Ed.) Common flax. The feed, and oil expreffed from the feed.— Linfeed, and linfeed oil.- This valuable annual plant, is faid to have come originally from thofe parts of Egypt which are expofed to the inundations of the Nile. It now grows wild among our fields, in the fouth of England, and many other parts of Europe, and is cultivated in large quantities. Linfeed contains about one fifth of mucilage, and one fixth of fixed oil. They are therefore confidered as emollient, and de- mulcent. The entire feeds are only ufed in cataplafms. The mucilage refides entirely in the fkin, and is feparated by infufion or decoaion. The infufion is ufed as a peaoral drink, and in ardor urinse, nephritic pains, and during the exhibition of corrofive fublimate. The oil is feparated by expreffion. It is one of the cheapeft fixed oils; but is generally rancid and naufeous, and unfit for in- ternal ufe. The cake which remains after the expreffion of the oil, contains the farinaceous and mucilaginous part of the feed, and is ufed in fattening cattle, under the name of Oil cake. Sp. 26. Linum Catharticum. Herba. (Dub.) Purging flax. This is an annual plant, found wild on dry meadows and paf- tures in Britain. Its virtue is expreffed in its title ; an infufion in water or whey of a handful of the freffi herb, or a dram of them in fubftance when dried, are faid to purge without incon- venience. LITHARGYRUS. (Dub.) See Plumbum. LOBKLIA SYPHILITICA. Radix. (Ed.) Lobelia. The root, 250 Materia Medica. [Part II. Syngenefia Monogamia.—Nat. ord. Campanacea: This plant grows in moift places in Virginia, and bears our winters. It is perennial, has an erea ftalk three or four feet high, blue flowers, a milky juice, and a rank fmell. The root confifts of white fibres about two inches long, refembles tobacco in tafte, which remains on the tongue, and is apt to excite vomiting. Dr. Barton fays, that it is confiderably diuretic, and Mr. Pear- fon found, that it generally difagreed with the ftomach, aud fel- dom failed ot affeaing the bowels as a ftrong cathartic. It certain. ly poffeffes no power of curing fyphilis; even the Indians, when they have the difeafe, are glad of an opportunity of applying to the whites. LUJULA. (Lond.) See Ox a lis. MAGNESIA VITRIOLATA. (Lond. Dub.) SeeSuL- phas Magnesia. MAJORANA. (Lond. Dub.) See Origanum. MALVA SYLVESTRIS. Herba. Flores. (Ed.) Malva. Folium. Flos. (Lond.) Willd. g. 1290. fp. 43. Monadelphia Polyandria.—Nat. ord. Columnifera. Common Mallow. The leaves and flowers. This is an annual plant, common in Britain, under hedges, near footpaths, and among rubbifh. The whole plant abounds with mucilage. The leaves were t formerly of fome efteem, in food,, for loofeningthe belly.; at pre- fent, decoaions of them are fometimes employed in dyfenteries, heat, and ffiarpnefs of urine,, and in general for obtunding acri- monious humors ; their principal ufe is in emollient gly Iters, cat- aplafms, and fomentations. MANNA. See Fr ax in us. MARRUBIUM VULGARE. Herba. (Ed. Lond.) Folia. (Dub.) White horehound. The leaves. -. Willd. g. mi. fp. 8. Didynamia Gymnofpermia.—Nat.ord. Verticillata. This is a perennial plant which grows wild on road fides and among rubbifh. The leaves have a very ftrong, not difagreeable fmell, and a roughifh very bitter tafte. They promote the fluid fecretions in general, and liberally taken, loofen the belly. fart. II.] Materia Mediea. 251 MARUM SYRIACUM. (Lond. Dub.) Set Teucrium. MASTICHE. SeePisxACiA. MEL. (Lond. Dub. Ed.) Honey. This is a well known fubftance, and although it is moft proh- bly of vegetable origin, we do not procure it in any quantity except as an animal excretion, from the bee, (apis mellifica.) This indullrious infect, in the fummer time flies from flower to flower to collea the fweet juice fecreted in them. When fufficiently loaded it returns to its hive, where it depofits it, as a winter's fupply in the cells of the comb it had prepared of wax to receive it. What change it undergoes in the body of the infea is un- known ; but it is certain, that honey varies very much, according to the nature of the plants from which it is colleaed. In fome fituations, where poifonous plants abound, it is even deleterious. The beft honey is that which is freeft from color, and contains the iargeft grains when it concretes. For medical ufe, it ffiould alfo be as tree of flavor as poffible. That obtained from young bees, and which flows fpontaneoufly from the combs, is the pureft and fineft, and is known by the name of Virgin honey. When feparated from the wax by expreffion, it is lefs pure ; and there is another fort ftill inferior, obtained by heating the combs before they are put into the prefs. Honey confifts principally of fugar, but it alfo probably can- tains mucilage and an acid, and is often impregnated with the ef- fential oil of the flowers from which the bees have gathered it. From the earlieit ages it has been employed as a medicine. Befides the general properties of faccharine bodies, it poffeffes others peculiar to itfelf, probably depending on the prefence of an acid. For internal ufe, fugar is always to be preferred, as honey in fome conftitutions produces gripes and colic pains. From its ftimulus, however, it forms an excellent gargle, and fa- cilitates the expeaoration of vifcid phlegm, and is fometimes em- ployed as an emollient application to abfceffes, and as a detergent to ulcers. MELALEUCA LEUCADENDRON. Oleum volatile. (Ed.) Cajeputaoffcinarum. The Cajeput tree. The effential oil. Polyadelphia Polyandria.—Nat. ord. Hefperidea. The tree which furnifhes the cajeput oil is frequent on the mountains of Amboyna, and other Molucca iflands. ft is obtain- ed by diftillation from the dried leaves of the fmaller of two varieties. It is prepared in great quantities, efpecially in the Ifl- and of Banda, and fent to Holland in copper flafks. As it comes 252 Materia Medica. [Tart II. to us it is ofa green color, very limpid, lighter than water, ofa ftrong fmell, refembling camphor, and a ftrong, pungent tafte, like that of cardamons. It burns entirely away, without leaving any refiduum. It is often adulterated with other effential oils, colored with the refin of the milfoil. In the genuine oil, the green color depends on the prefence of copper ; for when reaified it is color- lefs. Like other aromatic oils it is highly ftimulating, and is princi- pally recommended in hyfteria, epilepfy, flatulent colic, and para- lyfis of the tongue. The dofe is from one to four drops on a lump of fugar. It is applied externally where a warm and peculiar ftimulus is requifite ; it is employed for reftoring vigor after luxations and fprains, and for eafing violent pain in gouty and rheumatic cafes, in tooth ach and fimilar affedtions. MELISSA OFFICINALIS. Folia. (Ed.) Melififa. Herba. (Lond.) Balm. Tbe leaves. Willd.g. 1118. fp. 1. DidynamiaGymnofpermia.—Nat.ord. Verticillata. Balm is a perennial plant, which grows wild on the Alps and Pyrennees, and is frequently cultivated in our gardens. It has a pleafant fmell, fomewhat of the lemon kind ; and a weak, rough- i(h aromatic tafte. The young (hoots have the ftrongeft flavor ; the flowers, and the herb itfelf when old, or produced in very moift rich foils or rainy feafons, are much weaker both in fmell and tafte. It is principally ufed in the form of a watery infufion, which is drunk in the manner of tea. MELOE VESICATOR1US. (Ed.) Cantharis. (Lond.) Cantharides. (Dub.) Infecla, Coleoptera, Veficantia. Lytla vificatoria. Fabricii. These infeas have a longiffi, green and. gold ffiining body, with flexible green ftriped elytra, which cover the whole back of the body, and under which are their brown membranous wings. On their head they have two black articulated feelers. They are found on the fraxinus, fambucus, falix, liguftrum, &c. in Spain, Italy, France and Germany. The largeft come from Italy, but the Spaniffi cantharides are preferred. They are gath- ered by ffiaking the trees on which they are found, and catching them on a-cloth fpread beneath it. They are then killed by the funies of vinegar, and dried carefully in a ftove. The Melolontha vitis is fometimes found mixed in confiderable numbers with the cantharides. They are eafily diftinguifhed by their almoft Fart II.] Materia Medica. $5$ fquare body, and as probably they do not ftimulate the fkin, they (hould be picked out before the cantharides are powdered. Cantharides have a peculiar naufeous fmell, and an extremely acrid, burning tafte. Taken internally, they often occafion a dif- charge ot blood by urine, with exquifite pain; if the dofe be con- fiderable, they feem to inflame and exulcerate the whole inteftinal canal ; the (tools become mucous and purulent ; the breath fetid and cadaverous; intenfe pains are felt in the lower belly ; the pa- tient faints, grows giddy, delirious, and dies. Applied to the fkin, they firft inflame, and afterwards excoriate the part, raifing a more perfea blifter than any of the vegetable acrids, and oc- cafioning a more plentiful difcharge of ferum. But even the ex- ternal application of cantharides is often followed by a ftrangury, accompanied with thirft and feveriffi heat. The inconveniences arifing from the ufe of cantharides, wheth- er taken internally, or applied externally, are beft obviated by drinking plentifully of bland emollient liquids, fuch as milk, emulfions, &c. The fpecific property of counteraaing cantha- rides afcribed to camphor, has no foundation. The aaive conftituent of cantharides is not well afcertained. It is not diffipated by keeping for any length of time, and does not rife in diftillation. It is foluble in alcohol and in water. Gren and Hagen, both great authorities, fay, indeed, that it is in- foluble in v.ater ; but both the London, Dublin and Edinburgh Colleges, prepare an ointment from the watery infufion. The internal ufe of cantharides is at all times doubtful, and re- quires the moft prudent management. They have, however, been fometimes employed with fuccefs in dropfy, and in difeafes of the urinary organs, arifing from debility. They are given in fubftance in very fmall dofes, or in tinaure. Applied externally, they are one of our beft and moft power- ful remedies. By proper management, they may be regulated fa as to aa as a gentle ftimulus, as a rubefacient, or as a blifter. Blifters are applied, I. To increafe the aaivity of the fyftem in general, by means of their irritation. 2. To increafe the aaivity ofa particular organ. ft. To diminifh morbid aaion in particular organs, by means of the irritation they excite in the parts to which they are applied. They may be employed with advantage in almoft all difeafes accompanied with typhus fever, efpecially if any important vifcus as the brains, lungs, or liver, be at the fame time particularly af- feaed. In thefe cafes the blifters are not applied to the difeafed •rgans themfeivec, but a* near them as may be convenient* 254 Materia Medica. [Part. IT. When we wiffi to excite aaion in any organ, the blifters are, if poffible, applied direaiy to the difeafed organ.' m Cantharides are employed externally, either in fubftance, mixed up with wax and refin, fo as to form a plafter or ointment, or in the form of tinaure. MENTHA. Willd. g. 1102. Didynamia Gymnofpermia.—Nat. ord. Verti- cillata. Sp. 7. Mentha Viridis. Mentha fativa. Herba. (Lond. Dub.) Spearmint. The plant. Spearmint is perennial, and a native of Britain. The leaves have a warm, roughiffi, fomewhat bitteriffi tafte ; and a ftrong, not unpleafant, aromatic fmell. Their virtues arc ftomachic and carminative. Sp. 13. Mentha Piperita. Herba. (Ed.) Mentha piperitis. Herba. (Lond. Dub.) Peppermint. The plant. This fpecies of mint is alfo perennial, and a native of Britain. where it is cultivated in very great quantities for the fake of its ef- fential oil. The leaves have a ftrong, rather agreeable fmell, and an intenfely pungent, aromatic tafte, refembling that of pepper, and accompanied with a peculiar fenfation of coldnefs. Its predominant conftituents are effential oil and camphor, both of which rife in diftillation, and are combined in what is called Oil of Peppermint. Peppermint is principally ufed as a carminative and antifpafmodic. The diftilled water is a domeftic remedy for flatulent colic, and the effential oil is often given with advantage in dofes of a few drops in cramps of the ftomach. Sp. so. Mentha Pulegium. Herba. (Ed.) Pulegium. Herba. Flos. (Lond.) Herba. (Dub.) Pennyroyal. The herb and flower. This is alfo perennial, and a native of Britain. In its fenfible qualities, it is warm, pungent, and aromatic, fomewhat fimilar to fpearmint, but lefs agreeable. It is feldom ufed. MENYANTHES TRIFOLIATA. Folia. (Ed.) Trifdlium paludofum. Herba. (Lond.) Folia. (Dub.) Marfh Trefoil. The leaves. Willd.g. 2gg.fp. 4. Pentandria Monogynia.—Nat. ord. Rota- cea. This perennial plant is very common in marffiy fituations, and is one of the moft beautiful of our native flowers. Part II.] Materia Medica. 255 The leaves grow by threes on footftalks. They are exceffive- ly bitter, and their bitternefs is extraaed by infufion. They are faid to be fometimes ufed in brewing ale, and that one ounce will go as far as half a pound of hops. A drachm ot them in powder purges and vomits. In infufion or extraa they have been recommended in intermittents, in feveral cacheaic and cutaneous difeafes, the dofe of the extraa is from ten to twenty grains. MEZEREON. (Lond. Dub.) See Daphne. MiLLEPEDA. (Lond, Dub.) SeeONiscus. MIMOSA. Polygamia Monoecia.—Nat. ord. Lomentacea. Sp. Mimosa Catechu. Extraclum ligni. (Ed.) Catechu. Succus fpiffatus. (Lond. Dub.) Catechu. The extraa of the wood. This tree is a native of Hindoftan. The extraa of catechu, which was formerly termed, with peculiar impropriety, Japan earth, is principally prepared from the internal colored part of the wood by depoaion, evaporation, and exficcation in the fun. But catechu is alfo prepared in India from feveral other fpecies of mimofa, and even from the woods, barks, and fruits of other ge- nera. The catechu of the ffiops confifts of dry, hard, brittle maffes, of a reddifh brown color, differing confiderable in ffiade and inten- fity in different fpecimens ; fometimes of a lamellar texture of a more or lefs ffiining fraaure, of no fmell, and an aftringent fome- what bitteriffi tafte, fucceeded by a peculiar fweetnefs, which lafts a confiderable time in the mouth. It is not fufible; and when burnt leaves little refiduum. It is almoft entirely foluble in water and in alcohol. Thefe folutions ftrike a black color with fulphate of iron, and form a precipitate with gelatine. It therefore feems to contain a large proportion of tannin. The bit- ternefs would lead us to fufpea the prefence of extraaive; and it alfo very probably contains gum ; for gum exudes fpontaneoufly irom many of the fpecies of mimofa, and other trees, which, by decoaion furnifh aftringent extraas. It may be ufefully employed for moft purpofes where an aftrin- gent is indicated; and it is particularly ufeful in alvine fluxes. Befides this, it is employed alfo in uterine profluvia, in laxity and debility of the vifcera in general, in catarrhal affeaions and various other difeafes where aftringants are indicated. It is often fuffered to diffolve leifurely in the mouth, as a topical aftringent for laxities and exulcerations of the gums, for aphthous ulcers in 256 Materia Medica. [Fart If, the mouth and fimilar affections; and it is in fome other cafes applied externally, both under the form of folution and of oint- ment. Sp. Mimosa Nilotica. Gummi. (Ed.) Gummi Arabicu.a. (Lond. Dub) Gum Arabic. This fpecies of mimofa grows in Arabia Petnsa and Egypt; The greateft quantity of pure gum, commonly called Gum Ara- bic, is furniffied by this tree, from which it exudes either fpon- taneoufly, or from incifions made into the bark, and afterwards hardens in the air. But a perfeaiy fimilar gum may be obtained from all the fpecies of mimofa, and from many other trees, fuch as the Swietenia febrifuga, Melia azadirachta, and the different fpecies of Terminalia. It is remarkable that the barks of all the trees which furnifh this bland mucilaginous fubftance, are highly aftringent ; that of the mimofa nilotica itfelf is ufed in India for tanning ; and in our own country, the cherry and plumb trees, which fometimes yield a little gum, have very aftringent barks. Gum Arabic confifts of roundiffi tranfparent tears, of a yel* lowiffi color, ffiining fraaure, without fmell or tafte, and per- feaiy foluble in water. The pieces which are moft tranfparent and have leaft color are reckoned tbe beft. It poffeffes the powers of a mucilaginous demulcent in a high degree ; and is frequently exhibited in diarrhoea, dyfentery, chin- cough, hoarfenefs, ftranguary, &c. ; and is an extremely ufeful ar- ticle, for giving form to fome remedies, and for correaing the acrimony of others. MOMORDICA ELATERIUM. FruSus recens fubmalu- rus. (Ed.) Cucumis Agreflis. Fruclus recens. (Lond.) Fruclus. (Dub.) Wild cucumber. The freffi fruit, when almoft ripe. Monoecia Syngenefia.—Nat. ord. Cucurbitacea. This plant is a native of the fouth of Europe, and is perennial. When cultivated in this country, it does not furvive the winter, The fruit is oblong, about an inch and a half long, and an inch in diameter. It is of a green color, and befet with ftiff hairs. When nearly ripe, it burfts on a flight touch, feparates from its ftalk, and ffieds its feeds with great violence. From which circumftance it was named by the Greeks Elaterium, which name was alfo ap- plied to the faecula of the juice of the fruit, the only preparation ufed in medicine. In a tew grains it operates as a draftic purga- tive, and is fometimes ufed in dropfies. MO RUS NIGRA. Morus. Fruclus. (Lond.) fart II.] Materia Medica. 257 Mulberry tree. The fruit. Monoecia Tetrandria.—Nat. ord. Scabrida. This tree, which is fuppofed to have come originally from Per- fia, bears the cold of our winters, and ripens its fruit in England. The fruit has the fame properties with other fubacid fruits. Its juice contains tartarous acid. MOSCHUS MOSCHIFERUS. Materia in folliculo prope umbilicum collecla. (Ed.) Mofchus. (Dub.) Materia in folliculo prope umbilicum fiito collecla, (Lond.) The Mufk deer. Mufk. The fubftance contained in a folli- cle fituated near the navel. The mufk animal is an inhabitant of the moft elevated region of Alia, particularly of the Altayan Alps, and the mountains which divide Thibet from China. It is a gentle and timid ani- mal, and its chafe is difficult and dangerous. Its general form refembles the deer tribe, and it is about three feet in length. In the male, behind the navel and before the prepuce, there is fituated an oval bag, flat on one fiile and convex on the other, about three inches long and two broad, projeaing about an inch, and having a fmall open orifice, befet with ffiort hairs, which is empty in the young animal, but in the adult is filled with a fecreted matter, known by the name of mufk. When the bag becomes too full, the animal expreffes part of its contents by rubbing itfelf againft ftones or trees. The mufk expreffed in this manner is faid to be the pureft, but none of it probably reaches this country. The beft mufk is brought from Tonquin, an inferior fort from Agria and Bengal, and a ftill worfe from Ruffia. Fine mufk comes to us in round thin bladders ; which are gen- erally about the fize of a pigeon's egg, covered with ffiort brown hairs, lined with a thin brown membrane, well filled, and without any appearance of having been opened. The mufk itfelf is dry, with a kind of unauofity, of a dark reddiffi brown, or rufty blackiffi color, in fmall round grains, with very few hard black clots, and perteaiy free from fandy or other vifible foreign matter. If chewed, and rubbed with a knife on paper, it looks fmooth, bright, yellowiffi, and is free from grittinefs. Laid on a red hot iron, it catches flame, and burns almoft entirely away, leaving on- ly an exceeding fmall quantity of light greyifh afhes. The larg- eft and fulleft bag fcarcely contains more than two drachms of mufk. The very great price of mufk has given rife to many modes of adulterating it. To increafe its weight, fand, and even particles of lead, are introduced through very fmall openings into the bags. The real mufk is frequently abftracfed from the bag, and its place fupplied with dried and coarfely powdered blood, or fome mix- 258 Materia Medica. [Part II. ture with afphaltum. Thefe adulterations are to be deteaed by difcovering that the bag has been opened. The prefence of blood is alfo known by the fetid fmell it emits when heated fufficiently, and by the formation of ammonia when rubbed with potafs. Af- phaltum is known by its ffiining fraaure and melting on hot iron, while mufk is converted into charcoal. But there are even arti- ficial bags filled with a compofition containing fome real mufk, Thefe are in general thicker, and covered with longer hair, and want, the internal brown membrane which lines the real mufk- ba£- The charaaeriftic conftituent of mufk feems to be of the nature of an effential oil. It rifes in diftillation, and is foluble in alco- hol. Tbe reft of it feems to confift ofa fatty refinous matter. Mufk is a medicine of very great efficacy, and for which, in fome cafes, there is hardly any fubftitute. When properly ad- miniftered, it fometimes fucceeds in the moft defperate circum- ftances. It raifes the pulfe, without, heating much; it allays fpafms and operates remarkably on the brain, increafing the powers of thought, fenfation, and voluntary motion. It may be employed in every inftance of typhous fever, efpec- ially when attended with delirium, or fpafmodic affection of any particular organ, or of the whole fyftem, or fubfultus tendi- num, &c. It is alfo ufed^with the greateft benefit in exanthema- tous and phlegmonic difeafes, accompanied with typhoid fever ; and in many fpafmodic affeaions, as chincough, epilepfy, trifmus, &c. It is moft conveniently given in fubftance in powder, in dofes of three grains or upwards, repeated every one or two hours. lis beft preparation is the tinaure. MURIAS. Muriate is the generic term for thofe fecondary compounds which contain muriatic acid. Their general properties have been already mentioned (aio.) The muriates may be divided into three families : I. Alkaline muriates—foluble in water fufible, and vaporizable without decompofition, forming no precipitate with alkaline car- bonates. 2. Earthy muriates—foluble in water in general, decompofable by heat, forming a white precipitate with alkaline carbonates. 3. Metalline muriates.—The muriatic acid is capable of com- bining with many metals, in two ftates of oxidizement. The mu- riates which contain the metal more oxidized are in general very acrid, and foluble both in water and alcohol. The muriates which contain the metal lefs oxidized are often infoluble, have a white color, and cgntain an excefs of bafe, or are fubmuriates. The Part II.] Materia Medica. %& muriates are alfo the moft volatile metalline falts, and often rife undecompofed in fublimation or diftillation. ' MURIAS AMMONIA. (Ed.) Sal Ammoniacus. (Lond. Dub.) Muriate of ammonia is found native efpecially in the neigh- borhood ot volcanoes. It was firft prepared in Egypt from the foot of camel dung by fublimation. But the greateft part of that now Ufed is rnanufaaured in Europe, either by combining direaiy ammonia with muriatic acid, or by decompofing the fulphate of ammonia by means of muriate of foda, or the muriates of lime and magnefia by means of ammonia. In commerce, muriate of ammonia occurs either fublimed in firm, round, elaftic, concavo convex cakes, or cryftallized in co- nical maffes. The latter commonly contain other falts, efpecially muriate of lime, which renders them deliquefcent ; and therefore the fublimed muriate of ammonia is to be preferred for the pur- pofes of medicine. Muriate of ammonia has an acrid, pungent, urinous tafte. It is foluble in about three times its weight of water at 6o°, and in an equal weight at 212®. During its folution, it produces 32 de- grees of cold. It is alfo foluble in about 4-5 parts of alcohol. It is permanent in the ordinary ftate of the atmofphere. By a gen- tle heat, it may be deprived of its water of cryftallization, and reduced to the form of white powder. At a higher temperature it fublimes unchanged. Its cryftals are either fix fided pyramids, aggregated in a plumofe form, or ftill more commonly four fided pyramids. It confifts of 42. 75 muriatic acid, 25.00 ammonia, and §2. 25 water. It is decompofed by the fulphuric and nitric acids, by baryta, potafs, foda, ftrontia, and lime ; by feveral fe- condary falts, containing thefe acids or bafes ; and by thofe met- alline (alts whofe bafes form with muriatic acid an infoluble com- pound. Muriate of ammonia is now feldom ufed internally. It was formally fuppofed to be a powerful aperient and attenuant of vif- cid humors. Externally applied, it is a valuable remedy. It may aa in two ways, 1. By the cold produced during its folution. It is from this caufe that fomentations of muriate of ammonia probably prove beneficial in mania, apoplexy from plethora, le- tions of the head, and in violent headachs. When ufed with this intention, the folution ffiould be applied as foon as it is made. 2. By the ftimulus of the fait. On this principle we may explain its aaion as a difcutient in indolent tumors of all kinds, contufions, gangrene, pfora, oph- thalmia, cynanche, and in ftimulating clyfters. In fome cafes, aa 260 Materia Medica. [Part II. in chilblains and other indolent inflammations, both modes of ac- tion may be ferviceable. WThen firft applied, the cdldnefs of the folution will diminifh the fenfe of heat and uneafinefs of the part, and the fubfequent ftimulus will excite a more healthy aaion in the veffels. MURIAS SOD^E. (Ed.) Sal Muriatic us. (Lond.) Sal Communis. (Dub.) Muriate of foda. Common fea fait. This is the moft common of all the neutral falts. It is not only found in immenfe. maffes on, under, and above the earth's fur- face, and contained in great quantities in many fait fprings, but it is the caufe of the faltnefs of the fea. Native muriate of foda prefents two varieties, the lamellar and fibrous. It is found in Poland, Hungary, Spain, England, &c. When not perfeaiy pure, it is purified by folution and cryftalli- zation. Salt fprings occur in many pirts of the world. The quantity of muriate of foda contained in thefe varies, from an inconfidera- ble quantity, even up to one third. Sea water alfo varies much in ftrength. It is faid to contain moft fait in warm climates, and at great depths. Muriate of foda, as obtained from thefe natural folutions of it by evaporation and cryftallization, is feldom pure, but commonly mixed with earthy muriates, which being deliquefcent falts, dif- pofe it to attraa moifture from the atmofphere. It may, how- ever, be purified by precipitating the earths by means of carbo- nate of foda, or by waffiing the cryftallized fait with a faturated folution .of muriate of foda, heated to ebullition. In this ftate it is not capable of diffolving any more muriate of foda, but will diffolve a confiderable quantity of the earthy muriates. Muriate ot foda has a pure fait tafte, is foluble in 2.8 times its weight of water at 6o°, and in 2.76 at *i2°. It is not foluble in alcohol. By the aaion of heat it firft decrepitates, then melts, and laftly fublimes without decompofition. The primitive form of its cryftals is cubic, and they are permanent in the atmofphere. According to Kirwan, they confift of 38.88 muriatic acid, 53. foda, and 8.12 water. It is decompofed by the fulphuric and ni- tric acids, by potafs and baryta, by fecondary falts containing thefe, and by metalline falts, whofe bafe forms an infoluble com- pound with muriatic acid. It is alfo gradually decompofed by lime, iron, and litharge. Muriate of foda is one of the moft important articles in the arts, and in domeftic economy. As a medicine, it is ufeful in fome cafes of dyfpepfia; and in large dofes it is faid to check vomit- ing of blood. It is a common ingredient in ftiraulating clyIters, and is fometimes applied externally as-a fomentation to bruifes, Part. II.] Materia Medica. 261 or in the form of bath, as a gentle ftimulus to the whole furface of the body. MYRISTICA MOSCHATA. Fruclus nucleus, Nux Mof- chata diclus. Macis. Hujus oleum fixum, Olcam Macis ditlum. Oleum volatile. (Ed.) Myrifiica. Fruclus nucleus. Nux Mofchata diSus. Oleum ef- fentiale. Oleum expreffum, Oleum Macis vulgo diclum. Macis, (Lond.) Nux Mofchata. Oleum effentiale. Oleum expreffum. In volucrum, Macis diclum. (Dub.) The nut meg tree. The kernel of the fruit, commonly called Nutmeg. Its effential oil. Its expreffed oil, called oil of Mace. The involucrura of the nut (mace.) Monoecia Monandria.—Nat. ord. Oleracea. The tree which furnifhes this elegant fpice is a native of the Molucca iflands. It is not, however, cultivated in any of them except Banda, from which all Europe has been hitherto fupplied with mace and nutmeg. The entire fruit is about the fize of a peach, and is marked with a longitudinal furrow. The external covering is fmooth, fleffiy and bitter. As the fruit ripens, this burfts and difclofes the mace, which is an oily membranous pulp, of a dark red color and aromatic flavor, divided into narrow branched flips. Within the mace is inclofed the nut, which con- fifts of a brown, thin hard ffiell, and a fat parenchymatous kernel, of an oval ffiape. The fruit is gathered three times a year. The external covering is feparated on the fpot, and the mace and nut carried home, where they are carefully dried in the fun. After they are dried, the nutmegs are dipt in lime water, and the mace is fprinkled with fait water, probably to preferve them from the attacks of infeas. By drying, mace requires a reddiffi yellow color. When good, it is flexible, thin, oily, of a deep color, ftrong agreeable fmell, and an aromatic, bitteriffi, acrid tafte. When brittle, divi- ded into fewer flips, of a whitiffi or pale yellow color, and of lit- tle fmell or tafte, it is to be rejeaed. Dried nutmegs are oval, flattened at both ends, of a grey brown color, and reticularly furrowed on the outfide, of a yellow color within, variegated with brown undulating lines, folid, hard, unc- tuous to the teel, and eafily cut with a knife ; and have a balfamic fmell and agreeable aromatic tafte. The fmall round nutmegs are better than the large oval ones; and they ffiould have a ftrong fmell and tafte, and ffiould neither be worm eaten, mufty, nor variegated with black lines. Both mace and nutmegs are rather to be confidered as aromat- ic fpices than as articles of medicine. From the effential oil they containthey are heating and ftimulating, and they are added to other medicines for the fake of their agreeable flavor. U3-3 262 Materia Medica. [Part II, By diftillation they yield a confiderable quantity of effential oil, of a whitiffi yellow color, lighter than water, and poffeffing the aromatic tafte and fmell in an eminent degree. In dofes of a few drops, it is a powerful carminative and ftomachic. Nutmegs alfo yield, by expreffion, a confiderable quantity of limpid yellow oil, which on cooling concretes into a febaceous. confiftence. They are previoufly beaten to a foft pafte in a warm mortar, then inclofed in a linen bag, expofed to the vapor of hot water, and fqueezed in a prefs, of which the plates have been heated. In the ffiops we meet with three forts of unauous fubftances. called Oil. of Mace, though really expreffed from the nutmeg. The beft is brought from the Eaft Indies, in ftone jars ; this is of a thick confiftence, of the color of mace, and an agreeable fra- grant fmell : The fecond fort, which is paler colored, and much inferior in quality, comes from Holland in folid maffes, general- ly flat and of a fquare figure : The third, which is the worft of all, and ufually called Common Oil of Mace, is an artificial compofi- tion of fuet, palm oil, and thelike, flavored with a little genuine oil of nutmeg. The unauous fubftance obtained from nutmegs by expreffion, is a mixture of the volatile oil, on which their flavor depends, and of a fixed oil, of a white color, without tafte or fmell ; and as the properties which charaaerize it, depend on the prefence of the volatile oil, the denomination of Fixed Oil, applied to it by the Edinburgh College, is lefs correa than that of Expreffed Oil, given to it by the other Colleges, from the manner of its preparation. MYROXYLON PERUIFERUM. Balfamum. (Ed.) Balfamum Peruvianum. (Lond. Dub.) Sweet fmelling balfam tree. Peruvian balfam. Willd. g. $2g. fp. %. Decandria Monogynia,—-Nat. ord. Lomen* tacea, Thi§ tree grows in the warmed provinces of South America, and is remarkable for its elegant appearance. Every part of it abounds with refinous juice, even the leaves are full of tranfpa- rent refinous points, like thofe of the orange tree. The balfam as brought to us, is commonly of the confiftence of thin honey, of a reddiffi brown color, inclining to blade, an a- greeable aromatic fmell, and a very hot, biting tafte. It is very often adulterated, and fometimes what is fold for Peruvian balfam, is a fpurious mixture ot refin and effential oil, flavored with benzoin. Thefe frauds are not eafily deteaeA £nd fortunately they are of little importance Part II.] Materia Medica. 263 It is faid to be obtained by boiling the cuttings of the twigs in water, and flamming off with a fpoon the balfam which fwims on the top. There is another fort of balfam of Peru, of a white color, and confiderably more fragrant than the former. This is very rarely brought to us. It is faid to be the produce of the fame plant which yields the coramonorWa^ balfam ; and to exude from in- cifions made in the trunk. Befides the white, there is alfo a third kind, commonly called the red or dry. This is fuppofed to differ from the white, merely in confequence of the treatment to which it is fubjeaed after it is got from the tree. In its fragrance it in fome degree approaches to the balfam of Gilead, held in fo high efteem among the eaftern nations ; but it is very rarely in ufe in Britain, and almoft never to be met with in our (hops. Peruvian balfam confifts of a volatile oil, refin and benzoic acid. It is accordingly entirely foluble in alcohol, and in effential oils. Water diffolves part of the benzoic acid, and fixed oil combines with the refin. It may be fufpended in water by trituration with mucilage and yolk of eggs. Balfam of Peru is a very warm, aromatic medicine, confider- ably hotter and more acrid than Copaiva. Its principal effeas are, to warm the habit, and to ftrengthen the nervous fyftem. Hence its ufe in fome kinds of afthmas, gonorrhoeas, dyfenteries, fuppreffions of the uterine difcharges, and other diforders pro- ceeding from a debility of the folids. It is alfo employed exter- nally, for cleanfing and healing wounds and ulcers *, and fome- times againft palfies and rheumatic pains. MYRRHA. Gummi refina. (Ed. Lond. Dub.) Myrrh. A gum refin. The tree which produces this gum refin is not yet afcertained. Mr. Bruce has given fome reafons for fuppofing that it is a mi- mofa ; but we may obferve, that all the mimofas with which we are fufficiently acquainted, furnifh a pure gum, and not a gum refin. The beft myrrh is brought from Troglodytitia, a province of Abyflinia, on the borders of the Red Sea; but what we re- ceive comes from the Eaft Indies, and is produced on the eaftern coaft of Arabia Felix. The beft myrrh is in the form of tears. It ffiould be of a yel- low or reddiffi yellow color, becoming redder when breathed on, light, brittle, of an unauous feel, pellucid, ffiining ; prefent- ing white femicircular ftriae in its fracture ; of a very bitter, aro- matic tafte, and a ftrong, peculiar, not unpleafant odour. It is not good if whitiffi, dark colored, black, refinous, ill fmelled, or mixed with impurities, which is too commonly the cafe. Myrrh is not fufible, and is difficultly inflammable. It melt* entirely in the mouth, and is njuch more foluble in wateT than i« P°4 264 Materia Medica. [Part II. alcohol. The watery folution is yellow and opaque. The alco- holic folution is tranfparent, and when poured into water forms a yellow opaque fluid, but lets fall no precipitate. By diftillation with water, myrrh furnifhes a portion of effential oil. Myrrh is a heating, ftimulating medicine. It frequently oc- cafions a.mild diaphorefis, and promotes the fluid fecretions in gen- eral. Hence it proves ferviceable in cacheaic difeafes, arifing from inaaivity ot the fyftem, and is fuppofed to act efpecially upon the uterine fyftem, and to refift putrefa6tion. It is exhibited, 1. In fubftance ; in the form of powder, or made up into pills, in dofes of ten to fixty grains. 2. Diffolved in water, as in Griffiths' famous but unchemi- cal myrrh mixture. 3. Diffolved in alcohol. MYRTUS PIMENTA. Fruclus. (Ed.) Pimento. Bacca. (Lond.) Semina. (Dub.) Pimento tree. The fruit, commonly called Jamaica Pepper. Willd.g. 973.fp. 28. Icofandria Monogynia.—Nat. ord. Hef- Peridea. This is a native of Jamaica, and grows in all the woodlands on the north fide. Soon after the trees have bloffomed, and berries become fit for gathering ; the fruit not being fuffered to ripen, as in that ftate it is moift and glutinous, and therefore difficult to cure, and when dried becomes black and taftelefs. The berries are dried by fpreading them on a terrace, expofed to the fun, for about feven days, during which time they gradually lofe their green color and become of a reddiffi brown. The fmell of this fpice refembles a mixture ot cinnamon, cloves, and nutmegs ; its tafte approaches to that of cloves, or a mixture of the three foregoing ; whence it has received the name of all- fpice. Pimento is a warm, aromatic ftimulant, and is much ufed as a condiment in dreffing food. As a medicine, it is advantageouf- ly fubftituted for the more coftly fpices, efpecially in hofpital praaice. NASTURTIUM AQUATICUM. (Lond. Dub.) See Si. symbrium. NICOTIANA TABACUM. Folia. (Ed.) Nicotiana. Folium. (Lond. Dub.) Tobacco. The leaves. Willd.g. 379.fp. 1. PentandriaMonogynia.—NdX, ord. Sola- naceot. Part II.] Materia Medica. 265 This is an annual plant, a native of America, from whence it was firft brought into Eur»pe about the year 1560. It is now fometimes cultivated for medicinal ufe in our gardens ; but in general it is imported trom America in large quantities. The leaves are about two feet long, of a pale green color whilft frefh, and when carefully dried of a lively yellowifh caft. They have a ftrong, difagreeable, narcotic fmell, and a very acrid, burning tafte. On the living body, whether taken into the ftomach in fubftance or folution, or into the lungs in the form of fmoke, or applied to abraded lurfaces, tobacco is capable ot producing deleterious ef- feas. It often proves virulently cathartic or emetic, and occa- fions intolerable cardialgia, anxiety and vertigo. The fyftem becomes eafily habituated to the aaion of tobacco ; and many people ufe very large quantities of it in various ways as a luxury, without experiencing any other bad effea than what arifes from their being unable to relinquiffi it after the*habit is confirmed. The aaive conftituent of tobacco is an effential oil ; for, by long boiling, the decoaion and extraa of tobacco become almoft inert ; and by diftillation an oil is obtained from it, fo aaive, that fmall animals are almoft inftantly killed, when wounded by a needle dipped in it. As a medicine, it is exhibited in various forms : 1. In fubftance. When chewed it caufes an increafed flow of faliva, and fometimes relieves the toothach ; and reduc- ed to powder, it proves an excellent errhine and fternutato- ry, when fnuffed up the noftrils. 4. In infufion in water or wine. Taken in fuch fmall dofes as to have little effea on the ftomach, it proves powerful- ly diuretic, and was employed by Dr. Fowler with very great fuccefs in cafes of dropfy and dyfuria. It is alfo appli- ed externally for the cure of" pfora, tinea, and other cutane- ous difeafes. 3. In the form of fmoke, it is injeaed into the anus by means of bellows of a peculiar conftruaion. By aaing as a ftim- ulus to the reaum, it fometimes fucceeds in reviving the vital powers in fome kinds of afphyxia, and in evacuating the inteftines in cafes of obftinate conftipation. NITRAS. Nitrate is the generic term for fecondary compounds, which confift of nitric acid, combined with any bafe. Their general charaaers have been already mentioned (186.) There are three families of nitrates. 266 Materia Mediea. [Part II. i. Alkaline nitrates ;—foluble in water; folubility increafed by increafe of temperature ; cryftallizable ; forming no precipi- tate with alkaline carbonates. 2. Earthly nitrates ; foluble in water ; forming a white precj- pitatewith alkaline carbonates. 3. Metallic nitrates ;—generally foluble, both in water and in alcohol ; decompofable by heat, furnifhing nitric oxide gas, and leaving the metal oxidized to a maximum. NITRAS POTASS/E. (Ed.) Nitrum. (Lond. Dub.) Nitrate of potafs. Nitre. Nitrate of potafs is annually produced on the furface of the earth in many countries. For this produaion, the prefence of a calcareous bafe, heat, and an open, but not too free communication with dry atmofpheric, air, is requifite, the putrefaaion of orga- nic, efpecially animal fubftances, is not neceffary to, but accele- rates rhe formation of this fait, by affording the azote in a ftate in which it combines readily with the oxygen of the atmofphere, and forms the nitric acid. Accordingly, in Germany and France, ni- trate of potafs is prepared, by expofing mixtures of putrefying animal and vegetable fubftances, and calcareous earths, to the aaion of the atmofphere. The fait is afterwards extraaed by lixiviation and cryftallization. The nitre ufed in this country is chiefly imported from the Eaft Indies. As it occurs in commerce, it often contains a little muriate of potafs and muriate of foda, from which it is eafily purified by diffolving it in boiling water, and filtering it ; on cooling, the nitrate ot potafs cryftallizes, and the other falts remain diffolved. Nitrate of potafs has a ffiarp, bitteriffi, cooling tafte. It fhoots in pretty large cryftals, which are generally fix fided prifms, ter- minated by fix fided pyramids; very brittle, and permanent in the atmofphere ; foluble in feven times their weight of water at . 6o°, and in an equal weight at 2120 ; melting when expofed to a ftrong heat, giving out at firft oxygen, and afterwards nitrogen gas, until the whole acid be decompofed, and the potafs alone remain behind. It deflagrates more or lefs violently with all oxygeniz-, able fubftances, oxidizing or acidifying them. When dried in a temperature of 700, it confifts, according to Kirwan of 44. ni- tric acid, 51.8 potafs, and 4.2 water. It is decompofed by the fulphuric acid and baryta, by the muriate and acetite ot baryta, and the fulphates of foda, ammonia, magnefia, and alumina. Taken to the extent of from a drachm to half an ounce in the courfe of a day, in repeated dofes, it diminifhes the heat of the body, and the frequency of the pulfe, and operates by (tool, and aa$ upon the fecretion of urine, but is apt to produce pains in the ftomach. In large dofes, fuch as an ounce, taken at one time, i$ Part II.] Materia Medica. 267 produces the moftdreadful fymptoms,conftant vomiting, purging, mixed with blood, convulfions and death. Accidents of this kind have happened from its being fold by mi flake for fulphate of foda. It is belt given in fmall dofes, as five to ten grains frequently repeated, and is only admiflible in inflammatory difeafes. Exter- nally it is ufed in gargles, for inflammatory fore throats. NUX MOSCHATA. (Dub.) See Myristica. OLEA EUROP.EA. Fruclus oleum fixum. (Ed.) Oliva et ejus oleum. (Lond.) Oleum olivarum. (Dub.) The olive tree. The fruit, and oil expreffed from the fruit. Willd. g. 36. fp. %■ Diandria Monogynia.-—Nat. ord. Sepiaria. This tree is a native of the fouth of Europe and north of Afri- ca. It is cultivated in France, Spain, and Italy, for the fake of its fruit, and the oil expreffed from it. Olives when freffi, have an acrid, bitter, extremely difagreeable tafte ; but they are only eaten when pickled. They are firft fleeped tor feveral days in a ley of wood afhes, and then pickled in a ftrong folution of muri- ate of foda. They are principally valued for the oil they afford by expref- fion. For this purpofe they are gathered when fully ripe, and immediately bruifed and fubjeaed to the prefs. The fineft oil flows firft, and a very bad oil is obtained by boiling the magma which remains after expreffion, in water. Good olive oil ffiould have a pale yellow color, fomewhat in- clining to green, a bland tafte, without any rancidity, and no fmell, and fliould congeal at 380 Fahrenheit. In this country it is frequently rancid, and fometimes adulterated. Taken internally it operates as a gentle laxative, and is given in cafes of worms. It is alfo given in large quantities to mitigate the aaion of acrid fubftances taken into the ftomach. It is ufed externally in friaions, in gargles, and in clyfters ; but its princi- pal employment is for the compofition of ointments and platters. OLIBANUM. (Lond. Dub.) See Juniperus. ONISCUS ASELLUS. Millepeda: (Lond.) Millepeda fpiritus vini vapore enecata. Slaters killed by the vapor of alcohol. Infetla apt era. These infeas are found in cellars, under ftones, and in cold moift places ; in warm countries they are rarely met with- They have a faint difagreeable fmell, and a fomewhat pungent, fweetjfh, naufeous tafte. 268 Materia Medica. Pail II.] They have been analyzed by Thouvenel. Diftilled without addition in the water bath, they furniffied a quantity of alkaline water, and loft five eighths of their weight. Treated afterwards with water and alcohol, they yielded a fourth of their weight of extraaive and waxy fubftances. The expreffed juice of thefe infeas feemed alfo to contain mu> riate of potafs and of lime. Their medical virtues have been very much over rated. OPIUM. (Lond. Dub.) SeePAPAVER. OFOPONAX. (Lond.) See Pastinaca, ORIGANUM. Willd. g. 1116. DidynamiaGymnofpermia.—Nat. ord. Verti. eillata. Sp. 10. Origanum Vulgare. Origanum. Herba. (Lond.) Folia. (Dub.) Wild marjoram. The herb. This is a perennial plant, and is met with upon dry chalky hills, and in gravelly foils, in feveral parts of Britain. It has an agreeable fmell, and a pungent tafte, warmer than that of the garden marjoram, and much refembling thyme, with which it feems to agree in virtue. An effential oil diftilled from it is kept in the ffiops, and is very acrid. Sp. 15. Origanum Majorana. Herba. (Ed.) Majorana. Herba. (Lond. Dub.) Sweet marjoram. The plant. Sweet marjoram is an annual plant, which grows wild in Portugal, but is cultivated in our gardens, principally for culina- ry purpofes. It is a moderately warm aromatic, yielding its virtues both to aqueous and fpirituous liquors by infufion, and to water in diflil- lation. OSTREA EDULIS. Ofirea. Tefia. (Lond.) Putamina. (Dub.) Oyfter. The ffiell. CI. Vermes. Ord. Teflaeea. The oyfter is a very nutritious article of diet, and in fome dif- eafes not only admiffible, but even advantageous. Their (hells, which are officinal, are compofed, like all the mother of pearl ffiells, of alternate layers of carbonate of lime, and a thin membra- naceous fubftance, which exaaiy refembles coagulated albumen in all its properties. By burning, the membrane is deftroyed, Part II, J Materia Medica. 269 and they are converted into lime, which, although very pure, pof- feffes no advantage over that of the mineral kingdom. OVIS ARIES. Adeps. (Ed.) Ovis Sevum. (Lond.) Sevum. Ovillum. (Dub.) The ffieep. Mutton fuet. CI. Mammalia. Ord. Ruminantia. Mutton is a highly nutritious and wholefome food. Ewe milk is thick and heavy, and contains much cream and little whey. The cheefe made from it has a bitter biting tafte, efpecially whets old, and is fuppofed to be ftomachic. Mutton fuit is officinal, for the purpofe of giving confiftency to ointments and plaflers. OVUM. (Lond. Dub.) See Phasianus. OXALIS ACETOSELLA. Lujula. Folium. (Lond.) Acetofella. Folia. (Dub.) Wood forrel. The leaves. Willd. g. gi%.fp. 25. Decandria Pentagynia.—Nat. ord. Grtti- nales. This is a fmall perennial plant, which grows wild in woods, and fhady hedges. The leaves contain a confiderable quantity of fuper oxalate of potafs, and have an extremely pleafant acid tafte. They poffefs the fame powers with the vegetable acids in general, and may be given in infufion, or beaten with fugar into a conferve, or boiled with milk to form an acid whey. The fu- per oxalate of potafs is extraaed in large quantities from them and fold under the name of" Effential Salt of Lemons. ^OXIDUM ARSENICI. (Ed.) See Arsenicum. OXIDUM PLUMBI ALBUM. (Ed.) ---------:-------RUBRUM. (Ed.) ---------------SEMIVITREUM. (Ed.) See Plum- bum. OXIDUM Z1NCI IMPURUM. (Ed.) SeeZiNCUM. PANAX QU1NQUEFOLIUM. Ginfeng. Radix. (Lond.) Ginfeng. The Root. Polygamia Dicccia.—Nat. ord. Hederacea. This is a perennial plant, which grows in Tartary and North America. The root is about the thicknefs of the little finger; an inch or two in length, often dividing into two branches; ofa whi- tiffi yellow color; wrinkled on the furface ; of a compaa, almoft 0 270 Materia Medica. [Part II. horny texture ; when broken, exhibiting a refinous circle in the middle, of a reddiffi color. It has no fmell, but a very fweet tafte, combined with a flight degree of aromatic bitternefs. The Chinefe, probably on account of its fcarcity, have a very extraordinary opinion of the virtues of this rooty fo that it fells for many times its weight of filver. The Americans, on the con- trary, difregard it, becaufe it is found plentifully in their woods; In faa, it is a gentle and agreeable ftimulant. PAPAVER. Willd. g. 1015.—Polyandria Monogynia.—Nat. ord. Riceades. Sp. 5. Papaver Rhoeas. Papaver erraticum. Flos. (Lond.) Common rofe, or red poppy. The flower. Th 1 s fpecies of poppy is annual, and very common in our corn fields. The petals give out a fine red color when infufed, and are fuppofed to poffefs flightly anodyne properties. Sp. y. Papaver Somniferum. Capfula, et fuccus fpiffa- ins. (Ed.) Papaver album. Capfula, (Lond. Dub.) Opium (Lond. Dub.) White poppy. The capfules and their infpiffated juice, com- monly called opium. The white poppy is alfo an annual, and is fometimes found wild in this country, but it is probably originally a native of the warmer parts of Afia. In this country it is frequently cultivated for the beauty of the varieties of its flowers, and for its feeds. Some attempts have been made to obtain opium from its capfules; and Mr. Ball re- ceived a premium from the Society for encouraging the Arts, fdr fpecimens of Britiffi opium, in no refpea inferior to the beft eaftern opium. But we apprehend that the climate of this coun- try is an infuperable obftacle to its becoming a profitable branch of agriculture. For, fetting afide the chance of a total tailure of the crop from a few days rain, how could the produce of our pig- my poppies ever come in competition with that of the gigantic plants of the eaft, rifing, as we are told by travellers, to the height of forty feet, and bearing capfules thirtyfive ounces in weight! The leaves, ftalks and capfules of the poppy, abound with a milky juice, which may be colleaed in confiderable quantity, by flightly wounding them when almoft ripe ; this juice, expofed for a few days to the air, thickens into a ftiff tenacious mafs, which in faa is opium. By decoaion this juice is partially extraaed, to- gether with a confiderable quantity of mucilage. The liquor ftrong- ly preffed out, fuffered to fettle, clarified with whites of eggs, and evaporated to a due confiftence, yields about one fifth, or one fixth If art II.] Materia Medica. 271 the weight of the heads, of extraa. This poffeffes the virtues of opium but in a very inferior degree. A ftrong decoaion of the dried heads, mixed with as much fugar as is fufficient to reduce it into the conlftence of a fyrup, becomes fit for keeping in a li- quid form ; and is the only officinal preparation of the poppy.' It is, however, a very unequal preparation, as the real quantity of opium it contains is very uncertain, and by no means equal to fyrup, to which a certain quantity of folution of opium is added. The feeds of the poppy are fimply emulfive, and contain none of the narcotic principle. They yield a confiderable quantity of oil by expreffion. In the province of Bahar in the Eaft Indies, it is faid the pop- py feeds are fown in Oaober or November, at about eight inches diftance; and are well watered till the plants are about half a foot high, when a compoft ot nitrous earth, dung and aflies, is fpread over the areas ; and a little before the flowers appear, they are again watered profufely till the capfules are half grown ; and then the opium is colleaed ; for when fully ripe, they yield little juice. Two longitudinal incifions, from below upwards, without penetrating the cavity, are made at funfet for three or four fuc- ceffive evenings. In the morning the juice is fcraped off with an iron fcoop, and worked in an earthern pot in the funs heat till it be ofa confiftence to be formed into thick cakes, of about four pounds weight, which are covered over with the leaves of poppy or tobacco, and dried. Opium is a folid compaa fubftance, poffeffing a confiderable degree of tenacity ; when broken, having a ffiining fraaure and uniform appearance ; of a dark brown color, when moiftened, marking on paper a light brown interrupted ftreak, and becom- ing yellow when reduced to powder ; fcarcely coloring the fa- liva when chewed, exciting at firft a naufeous bitter tafte, which feon becomes acrid, with fome degree of warmth ; and having a peculiar heavy difagreeable fmell. It is bad if it be foft, friable, mixed with any impurities, have an intenfely dark or blackifh color, a weak or empyreumatic fmell, a fweetiffi tafte, or draw upon paper a brown continuous ftreak. Opium is not fufible, but is foftened even by the heat of the fingers. It is highly inflammable. It is partially foluble, both in alcohol and in water. The folutions are tranfparent, and faave a dark brown color. The watery folution is not decompofed by alcohql. A fmall quantity of refin is feparated from the alcohol- ic folution by water. Alcohol, or water diftilled from opium, are impregnated with its narcotic virtues, which by long boiling, roafting, or great age, are diminiffied, or entirely diffipated. The part of opium which is infoluble either in water or in alcohol, is albumen according to Gren, caoutchouc according to Buchholtz, a virulent glutinous fubftance according to Joffe; and Preuii 272 Materia Medica. [Part II. fays it contains wax. From experiments made fome years ago, we concluded that it was perfeaiy fimilar to the gluten of wheat flour or fibrine. Upon the whole it appears that the aaive con- * ftituent of opium, though not perfeaiy underftood, is of a volatile nature, but fomewhat fixed by its combination with the other con- ftituents ; that it is foluble both in water and in alcohol; that it is diffipated in the proceffes recommended for purifying opium by folution and evaporation ; and that the attempts, made by fome pharmaceutifts, to obtain a preparation of opium, which ffiould poffefs only its fedative, without its mrcotic effeas, only fucceed- ed in fo far as they diminiffied its aaivity. The aaion of opium on the living fyftem, has been the fubjea of the keeneft controverfy. Some have affcrted that it is a dire6t fedative, while others have afferted as ftrongly, that it is a power- ful ftimulus, and that the fedative effeas, which it certainly pro- duces, depend entirely on the previous excitement. We cannot here pretend to give even an abftraa of the arguments ufed by the fupporters of each opinion. We regret ftill more, that the contradiaory refults of their experiments render it difficult to af- certain even its primary and vifible effeas. Opium, when taken into the ftomach to fuch an extent as to have any fenfible effea, gives rife to a pleafant ferenity of mind, in general proceeding to a certain degree of languor, and drowfi- nefs. The aaion of the fanguiferous fyftem is diminiffied, the pulfe becoming for the moft part fofter, fuller, and flower than it was before. By many, on the contrary, it is faid, in the firft inftance at leaft, to increafe the frequency of the pulfe, and the heat of the body. It diminiffies all the fecretions and'excretions, except the cuticular difcharge, which it frequently augments in a very fen- fible degree; It excites thirft, and renders the mouth dry and parched. Opium taken into the ftomach in a larger dofe, gives rife to confufion of head and vertigo. The power of all ftimulating caufes of making impreflions on the body, is diminiffied ; and even at times, and in fituations, when a perfon would naturally be awake, fleep is irrefiftibly induced. In ftill larger dofes, it aas in the fame manner as the narcotic poifons, giving rife to vertigo, headach, tremors, delirium, and convulfions ; and thefe terminat- ing in a ftate of ftupor, from which the perfon cannot be roufed. This ftupor is accompanied with flownefs of the pulfe, and with ftertor in breathing, and the fcene is terminated in death, attend- ed with the fame appearances as take place in an apoplexy. From thefe effeas of opium in a ftate of health, it is not won- derful that recourfe ffiould have been had to it in difeafe, as miti- gating pain, inducing fleep, allaying inordinate aaion, and dimin- iffiing morbid fenfibility. That thefe effeas refult from it, is Part II.] Materia Medica. 2»73 confirmed by the daily experience of every obferver ; and as an- fwering one or other of thefe intentions, moft, if not all, of the good confequences derived from it in aaual praaice, are to be explained. It, therefore, by a fedative medicine, we mean an ar- ticle capable of allaying, affuaging, mitigating, and compofing, nd fubftafice can have a better title to the appellation of fedative than opium. Some praaitioners are averfe to its ufe where an aaive inflam- mation takes place ; 'but others have recourfe to it in fuch cafes, even at an early noriod, efpecially after bloodletting ; and where fuch affeaions are attended not only with pain and fpafm, but with watchfulnefs and cough, it is often productive ot the greateft benefit. Opium combined with calomel has of late been exten- fively employed in every form of aaive inflammation, and with / the greateft fuccefs. It is found alfo to be of very great fervice in allaying the pain and preventing the fymptomatic fever liable to be induced by Wounds, fraaures, burns, or fimilar accidents. In intermittents, it is faid to have been ufed with good effea before the fit in the cold ftage, in the hot ftage, and during the interval. Given even in the hot ftage, it has been obferved £0 allay the heat, thirft, headach, and delirium, to induce fweat and fleep, to cure the difeafe with lefs bark, and without leaving ab- dominal obftruaions or dropfy; It is often ot very great fervice in fevers of the typhoid type, whert patients are diftreffed with watchfulnefs or diarrhoea. But where thefe or fimilar circumfla _?s do not indicate its ufe, it is often diftreffing to patients by augmenting thirft and conftipation. In fmall pox, when the convulfions before eruption are fre- quent and confiderable, opium is liberally ufed. It is likewife given from the fifth day onwards ; and is found to allay the pain of fuppuration, to promote the ptyalifm, and to be otherwife ufeful. In dyfentery, alter the ufe of gentle laxatives, or along with them, opium, independently of any effea it may have on the fe- ver, is of confequence in allaying the tormina and tenefmus, and in obviating that laxity of bowels which fo frequently remains after that difeafe. In diarrhcea, the difeafe itfelf generally carries off any acrimo- ny that may be a caufe, and then opium is ufed with great effea. Even in the worft fymptomatic cafes, it feldom fails to alleviate. In cholera and pyrofis, it is almoft the only thing trufted to. In colic, it is employed with laxatives ; and no doubt often pre- vents ileus and inflammation, by relieving the fpafm. Even in ileus and incarcerated hernia, it is often found to allay the vom- iting, the fpafms, the pain, and fometimes to diminifh the inflam- mation, and prevent the gangrene ot the ftrangulated gut. It is given to allay the pain and favor the defcent of calculi, and to relieve in jaundice and difuria proceeding from fpafm. 274 Materia Medica. [Part. II. It is of acknowledged ufe in the different fpecies of tetanus; affords relief to the various fpafmodic fymptoms of dyfpepfia, hy- fteria, hypochondriafis, afthma, rabies canina, &c. and has been found ufeful in fome kinds of epilepfy. In fyphilis it is only ufeful in combating fymptoms, and in counteraaing the effeas refulting from the improper ufe of mer- cury, for it poffeffes no power of overcoming the venereal virus. It is found ufetul in certain cafes of threatened abortion and lingering delivery, in convulfions during parturition, and in the after pains and exceffive flooding. The only form perhaps neceffary for opium is that of pill; and as it is fo foluble in every menftruum, there feems the lefs occa- fion for the addition of either gum or foap. This form is more apt to fit on the ftomach than any liquid form, but requires rather more time to produce its effeas. The adminiftration of opium to the unaccuftomed, is fometimes very difficult. The requifite quantity of opium is wonderfully different in different perfons, and in different ftates of the fame perfon. A quarter of a grain wiil in one adult produce effeas which ten times the quantity will not do in another ; and a dofe that might prove fatal in cholera or colic, would not be perceptible in many cafes of tetanus or ma- nia. The loweft fatal dofe to the unaccuftomed, as mentioned by authors, feems to be four grains ; but a dangerous dofe is fo apt to puke, that it has feldom time to occafion death. When given in too fmall a dofe, it is apt to produce difturbed fleep, and other difagreeable confequences ; and with fome conftitutions it feems not to agree in any dofe or form. Often, on the other hand, from a fmall dofe, found fleep, and alleviation of pain will be pro- duced, while a larger one gives rife to vertigo and delirium. Some prefer the repetition of fmall dofes, others the giving ofa full dofe at once. In fome it feems not to have its proper effea till after a confiderable time. The operation of a moderate dofe is fuppofed to laft in general about eight hours from the time of taking it. PAREIRA BRAVA. (Lond. Dub.) See Cissampelos. PARIETARIA OFFICINALIS. Parietaria. Herba. (Lond.) Pellitory of the wall. The herb. Polygamia Monacia.—Nat. ord. Siabrida. This is a fmall plant growing uptn old walls; of an herbace- ous fubfaline tafte, without any fnce . PASTINACA OPOPONAX. Opoponax. Gummi refina. (Loi&i,) Opoponax. A gum refin. fcart. II.] Materia Medica. 275 Willd. g. ,558. fp. 3. Pentandria Digynia.—Nat. ord. Umbel- la ta. This plant is perennial, and grows wild in the fouth of Eu- rope ; but the gum refin which is faid to be obtained by wound- ing the ftalk or root, is brought from the Levant and Eaft Indies, fometimes in round drops or tears, but more commonly in irregu- lar lumps, of a reddiffi yellow color on the outfide with fpecks of white, inwardly of a paler color, and frequently variegated with large white pieces. It has a peculiar ftrong fmell, and a bit- ter, acrid, fomewhat naufeous tafle. It forms a milky folution with water, and yields a little effen- tial oil on diftillation. It is fuppofed to be emmenagogue, but is rarely ufed. PENTAPHYLLUM. (Lond.) See Potentilla. PETROLEUM. (Lond.) Petroleum Barbadence. (Dub.) See Bitumen. PETROSELINUM. (Lond.) See Apium. PHASIANUS GALLUS. Ovum. (Lond.) Ovum; putamen. (Dub.) The dunghill fowl. The egg, and egg ffiell. Cl. Aves. Ord. Gallina. From what country this ufeful bird originally came, is not as- certained. It is now dorriefticated almoft every where,'and fur- nifhes one of the moil wholefome and deiicate articles of food. The egg only is officinal. The ffiell confifts principally oF. carbonate of lime, with a fmall quantity of phofphate of lime and animal matter. When burnt, the animal matter and carbonic acid are deftroyed, and we obtain a lime, mixed with a little phofphate of lime. The contents of the egg confifts of two fubftances, the white, and the yolk. The white is albumen, combined with a little foda and fulphur. The yolk is alfo albuminous, but contains alfo a bland oil, and fome coloring matter. The latter is fometimes uf- ed in pharmacy for fufpending oily and refinous fubftances in wa- ter. The former is ufed only for clarification (S. 2. 53.) PHYSETER MACROCEPHALUS, Sevum. (Ed.) Spermaceti. (Lond.) Spermaceti. (Dub.) Spermaceti whale. The fuet. Spermaceti. Cl. Mammalia. Ord. Cetacea. \ The fpermaceti whale is charaaerized by his enormous head great part of which is occupied by a triangular cavity of bone, covered only by the common integuments. In the living animal his cavity filled is with a white, fluid., oily fubftance, amounting 8^T e • 276 Materia Medica. [Part II. fometimes to many tons in weight. On the death of the whale, it congeals into a white unauous ma Is, from which a confiderable quantity of very pure whale oil is obtained by expreffion. The refiduum, afterwards freed from impurities, by waffiing with wa- ter, melting, ftraining, expreffion through linen bags, and, laft- ly, wafliing in a weak ley of potafs, is the peculiar fubftance well known by the name of Spermaceti. It is alfo contained in folu- tion in the common whale and other fiffi oils ; for it is often found depofited by a fpecies of cryftallization, in the refervoirs contain- ing them. The chemical properties of fpermaceti have been already (242.) noticed. . As a medicine for internal ufe, it agrees with the fixed vegetable oils -r and in the compofition of ointments &c. its place may be very well fupplied by a mixture of oil and wax. PIMENTO. (Lond. Dub.) See Myrtus. PIMP1NELLA ANiSUM. Semen. (Ed.) Anifum. Semen. (Lond. Dub,) An;fe. The feed. Willd. g. 56-2. fp. 8. Pentandria Digynia.—Nat. ord. Umbei- lata. Anise is an annual umbelliferous plant, growing naturally*in Crete, Syria, and other places of the eaft. It is cultivated in fome parts of France, Germany, and Spain, and may be raifed alfo in England. The feeds brough^from Spain, which are fmaller than the others, are preferred. Anifeeds have an aromatic fmell, and a pleafant warm tafte, ac- companied with a degree of fweetnefs. Water extraas very little of their flavor ; reaified fpirit the whole. PINUS. Monacia AdtlpMa.*—Nat. ord. Conifera. Sp. Pinus Abies. Refina. (Ed.) Pix Burgundica. (Lond. Dub.) Thus. Refina. (Lond.) Common fpruce fir. Burgundy pitch. Common frankincenfe. Sp. PinusBalsamea. Refina. (Ed.) Balfamum Canadenfe. (Lond. Dub.) Hemlock fir. Balfam of Canada. Sp. Pinus Larix. Refina et Oleum volatile. (Ed.) Terebinthina Verieta. (Lond. Dub.) The larch. Venice turpentine. Oil of turpentine. Part IIr] Materia Medica. 277 Sp. Pinus Sylvestris. Refina. (Ed.) Pix tiquida. (Lond. Dub.) Terebinthina vulgaris. (Lond. Dub.) Scotch fir. Tar. Common turpentine. These different fpecies of fir are all natives of fandy fituations. The laft only grows wild in this country. They all abound in every part with a refinous juice, which poffeffes the fame general qualities, but prefents fome varieties, according to the nature of the fpecies and mode of preparation. We may arrange the produas, i. Into thofe which exude fpontaneoufly. 2. Into thofe procured by wounding the tree. 3. Into thofe procured by decoaion. And 4. In,to thofe which are procured by the aaion of fire. From the pinus abies, and perhaps from the pinus fyiveflris, in warm feafons and climates, a refinous jtwee exudes fpontarte- oufly, which hardens into tears. It is the Thus of the London Pharmacopoeia, or common frankincenfe. The pirtus larix exudes a fpecies of manna, called Briancon Manna, but which is not ufed ; as, befides the faccharine maitcrs, it evidently contains turpentine. To obtain the products of the fecond kind, a feries of w«unds are made through the bark, beginning at the bottom, and rifing gradually upwards, until a ftripe of the bark, about nine feet high, be removed, which is commonly effeaed in about four years. The fame operation is then repeated on the oppofite fide. The operation is then recommenced clofe to the edge of the for- mer wound, which by this time is nearly clofed. A tree worked in this manner will furvive and furnifh turpentine for near a cen- tury. The juice which flows from thefe wounds during fummer, is.collecied in a fmall cavity, formed in the earth at the bottom of the incifions, from which itis occafionallyremoved into proper refervoirs previous to this purification. As the trees exude very little juice during cold weather, no new incifions are made in win- ter ; but the old ones get covered with a foft refinous cruft, called barras, galipot, or white refin, which is fcraped off, and alfo col- leaed for fubfequent purification. Both thefe produas are purified by liquefaaion and filtration. They confift almoft entirely of an effential oil, and a refin, and dif- fer only in the proportions, the turpentine containing moft oil, and the galipot moft refin. Turpentines have different appellations according to the fpecies of tree from which they are procured. Balfam of Canada. Pinus balfamea et Canadensis. Cyprian turpentine. Piftacia tcrebinthus. Strafbucgh turpentine. Pinuspuea. p-3 278 Materia Medica.' Part II] Venice turpentine. Pinus larix. Common turpentine. Pinus fylvefris. Hungarian balfam. --------- var. Mughos. Carpatian balfam. Pinus cembra. None of thefe are properly balfams ; which term is now ufed, to exprefs thofe oily refinous fubftances only which contain ben- zoic acid. The Edinburgh Collage have denominated them re- fins, but the proportion of effential oil which they contain is much too large to admit of the name, which ought to be confined to the other conftituent, being applied to the compound with propri- ety. Therefore,until more attention fliall be paid to this branch of nomenclature, We fliall employ the common term ot Turpentine. The effential oil, commonly called Oil of Turpentine, may be procured trom any of thefe by diftillation. The refiduum of the diftillation gets different names, according to fome peculiarities in its treatment. When the diftillation is performed without addition, and continued until the whole effen- tial oil be driven off, and there appear fome traces of empyreu- ma, the refiduum is Common Refin or Colophony ; but it, while the mafs is ftill fluid, a quantity of water be added, and thorough- ly blended with the refin by long and conftant agitation, it is then called Yellow Refin. Although galipot contains effential oil, the quantity is fo fmall that it is never diftilled from it. It is purified by melting it with a very gentle fire, and filtrating it. By this procefs it ftill contains effential oil, and is the fubftance known by the name of Burgun- dy Pitch. If boiling water be added to it after it is drained, but while it is flill fluid, and they be agitated together till the mafs cools, we have a yellow refin, which, from ftill, containing fome effential oil, is preferred to that prepared by a fimilar procefs from common refin. A fluid extraa prepared by decoaion from the twigs of the pinus fylveftris, is the well known effence of fpruce, which fer- mented with molaffes, forms the fafhionable beverage of fpruce beer. The laft kind of produas from the different fpecies of fir are obtained by the aaion of fire. With this view, a conical cavity is dug out in the earth, communicating at the bottom with a re- fervoir. Billets or thin laths of wood are then placed fo as not only to fill the cavity, but to form a conical pile over it, which is covered with turf, and kindled at the top. The admiffion of an* isfo regulated, that it burns from above downwards, with a flow and fmothered combuftion. The fmoke and vapors formed are obliged to defcend into the excavation in the ground, where they are condenfed, and pafs along with the matters liquefied into the receiver. This mixture is denominated Tar; and the v^ood Part II.] Materia Medica. -~9 itfelf is reduced to charcoal. By long boiling, tar is deprived of its volatile parts, and converted into pitch. But the moft remarkable produaion is that of a real gum, en- tirely foluble in water, from a tree fo refinous as the Pinus larix. It is prepared in the Ural larch forefts ; and exudes, according to profeffor Pullas, from the interior parts of the wood when it is burning. We fhall now proceed to notice more particularly, fuch of thefe fubftances as are officinal. Terebinthin a. Balfamum Canadenfe. (Lond. Dub.) Refina pini balfamex. (Ed.) Terebintkina Chia. (Lond.) ------------ piflacia lentifci. Terebinthina Veneta. (Lond. Dub.) Refina pini laricis. (Ed.) Terebinthina vulgaris. (Lond. Dub.) -----------pini fylvefiris. . * All thefe fpecies of turpentine poffefs the fame general pior perties. They are more or lefs fluid, with different degrees of tranfparency ; of a whitiffi or yellowiffi color ; a penetrating fmell, and a warm pungent bitteriffi tafte. They are entirelv fo- luble in alcohol; combine with fixed oil ; and impart their fla- vor to water, but are not foluble in it. They are decompoled by a moderate heat, being feparated into an effential oil and a rcfiu, and are exceedingly inflammable, burning with a large white flame, and much fmoke. Each fpecies has fome peculiarities. The Canadian is reckon- ed the beft, and next to it the Chian. They are more tranfparent, and have a more agreeable flavor than the other forts- i hr com- mon turpentine, as being the moft offenfive, is rarely given in- ternally ; its principal ufe is in plafters and ointments among far- riers, and for the diftillation of the effential oil. Taken internally, they are aaive ftimulants, increafe the fecre- tion of urine, to which they give the fmell ot violets, even though applied only externally, and open the bowels. They arc principally recommended in gleets, the fluor albu.s, and the like ; and by fome in calculous complaints : In all cafes accompanied with inflammation, they ought to be abftained from, as this fymptom is increafed, and not untrequently occafioned by them. Their dofe is from a fcruple to a drachm and a half; they are moft commodioufly taken in the form of a bolus, or blended with watery liquors by the mediation of the yolk of an egg or mucilage. But they are more frequently ufed externally as ftimulants and difcutients, and enter feveral officinal plziters and ointments, v^4 280 Materia Medica. [Part II- Oleum Terebinthina Volatile. (Ed.) In the Edinburgh Pharmacopoeia, this effential oil is officinal j by the other Colleges direaions are given for this preparation. It is lighter than water, tranfparent, limpid, and volatile. If has a hot pungent tafte, and a penetrating fmell ; is highly in- flammable, and poffeffes all the other properties of cffen-tial oils, (248-) As a medicine it is highly ftimulating and penetrating. Inter- nally it aas as a diuretic or fudorific in very fmall dofes. It has however, been given in much larger dofes, efpecially when mix- ed with honey. Recourfe has principally been had to fuch dofes in cafes of chronic rheumatifm, particularly in thofe modifications of it which are ftyled fciatica and lumbago. But they have not been often fuccefsful, and fometimes they have had the effea of inducing bloody urine. Externally, it often produces excellent effeas as a difcutient in indolent tumors ; as a ftimulus in paralyfis of the extremities, and in bruifes ; as an antifpafmodic, and as a ftyptic, when ap- plied as hot as the patient can bear it, or compreffes direaiy tq fhe bleeding mouths of the veffels. Resina. Refina alba. (Dub.) Thus. (Lond.) Refina pini abietis. (Ed.) Pix Burgundica. (Dub.) These are not pure refins, as they ftill contain fome effential oil. They are obtained from feveral fpecies of fir, indifferently. The firft kind is a fpontanepus exudation, which takes place in dry and warm weather, hardened by expofure ; and the laft is the cruft, which colleas in winter upon the wounds infliaed for ob- taining the turpentines, fimply purified by percolation. The firft is a folid, brittle refin, brought to us in little globes or maffes ofa brownifh or yellowiffi color on the out fideJf* inter- nally whitiffi or variegated with whitiffi fpecks, of a bitterifh, acrid, not agreeable tafte, without any confiderable fmell. The fecond is of a folid confiftence, yet fomewhat foft, of a reddiffi brown color, and hot difagreeable fmell. They poffefs the general properties of refins (251.} and are on- ly ufed externally in the compofition of plafters. Pix Liquida. (Lond. Dub.) Refina pmifylvefiris. (Ed.) Tar is a mixture of refin, empyreumatic oil, charcoal, and ace- tous acid. Its color is derived from the charcoal ; and the other properties in which it differs from a common refin, depend on the prefence of acetous acid and empyreumatic oil. The acid itfelf is not only foluble in water, but it alfo renders }he empyreumatic oil foluble in larger quantities than it othervvi(e Part II.] Materia Medica. 28* would be. Tar water is a heating diuretic and fadorific remedy, but by no means fo powerful, or To generally admiflible as it was reprefented by Bifhop Berkeley. Tar is applied externally in tinea capitis, and fome other cutaneous difeafes. PIPER INDICUM. (Lond. Dub.) See Capsicum. PIPER. Willd.g. y\. Diandria Trigynia.—Nat. ord. Piperita. Sp. 1. Piper Nigrum. Bacca. (Lond.) Fruclus. (Ed.) Semina. (Dub.) Black pepper. The berry. The black pepper is the fruit ot a ffirubby, creeping plant, which grows wild in the Eaft Indies, and is cultivated in Java and Malabar, by which means the fruit is much improved. The berries are gathered before they are ripe, and are dried in the fun, They become black and corrugated on the furface; their tafte is hot and fiery, and their fmell flightly aromatic. -* White pepper is the fruit of the fame plant, gathered after it is fully ripe, and freed of its external coat by maceration in water1. It is fmooth on the furface, and lefs pungent than the black pep- per, Sp. 3. Piper Cubeba. Cubeba. (Lond.) Cubebs. Cubebs are a fruit brought from Java. This fruit has a great refemblance to pepper. The principal difference diftinguifhable by the eye, is, that each cubeb is furniffied with a long flender ftalk, whence they are called by fome piper caudatum. In aro- matic warmth and pungency, cubebs are far inferior to pepper. Sp. 12. Piper Longum. Fruclus. (Lond.Ed.) Semina. (Dub.) Long pepper. The fruit. The plant which bears the long pepper is alfo a farmentaceous climber. The berries are fmall round grains, difpofed IpiraUy in a long cylindrical head. They are gathered before they are ripe and dried, and are the hotteft of all the peppers. The warmth and pungency of thefe fpices refide entirely in a refin ; their aromatic odour in an effential oil. In medicine they are fometimes employed as acrid ftimulants ; but their chief ufe is in cookery as condiments. PISTAC1A. Djioecia Pentandria.—Nat. ord. Amentacea. 282 Materia Medica. [Part II. Sp. Pistacia Terebinthus. Terebinthina Chia. (Lond.) Chian turpentine. The tree which yields this turpentine, grows in India, the north of Africa, and fouth of Europe, but the turpentine is principally collected in the iflands of Chios and Cyprus, by wounding the tree. It does not differ in any thing material, except its price, from the other turpentines. See Pin us. Sp. Pistacia Lentiscus. Refina. (Ed.) Mafiicke. Refina. (Lond.) Maftich. A refin. This fpecies is a native of the fame countries with the former. It is obtained principally in theifjandof Chios, by making tranf- verfe incifions in the tree, and allowing the juice to harden. It is brought in fmall yellowiffi, femi tranfparent, brittle grains ; ofa fmooth and ffiining fraaure, foftening when chewed, fufible, burning* with a pleafant fmell, and foluble in alcohol and fixed Wils. Its flavor is communicated to water. It is therefore a re- fin, combined with a little effential oil. It is principally ufed by the Turkiffi women as a mafticatory, to preferve the teeth, and give a pleafant fmell to the breath. PIX BURGUNDICA. {Lond. Dub.) PIX LIQU1DA. (Lond. Dub.) See Pinus. PLUMBUM. (Ed. Lond.) Lead. The general properties of lead have been already (192.) enu- merated. Lead is found, 1. Oxidized : 1. Lead ochre of different colors. II. Oxidized, and combined with acids : 2. Carbonated lead. White lead fpar. 3. Murio carbonated. 4. Phofphated lead. Green lead ore. 5. Arfeniated lead. 6. Arfenio phofphated lead. 7. Molybdated lead. 8. Sulphated lead. III. Sulphuretted : 9. Sulphuretted lead. Galena. • jo. Sulphuretted oxide of lead. Lead is obtained by various proceffes from thefe ores. In its metallic form it is fcarcely an officinal article, as its different ox- Part II. ] Materia Medica. 233 Jdes are purchafed from the manufaaurers, and never prepared by the apothecary. Its effeas on the body are emaciation, violent colics, paralyfis, tremors and contraaions of the limbs ; and as they generally come on gradually, the caufe is fometimes overlooked till it be too late. Poifoning from lead is nev^r intentional, but only accidental, ei± ther from liquors becoming impregnated with lead, by being im- properly kept in veffels lined or glazed with lead, or to which lead has been criminally added to correa its acidity ; or among manu- faaurers who work much with lead, as painters and plumbers, and who are not fufficiently attentive to avoid {'wallowing any of it. The prefence of lead in any fufpeaed liquor isdeteaed by the hydro fuiphuret of potafs, which forms with it a brown precipi- tate, not foluble in diluted muriatic acid ; and ftill more certain- ly by evaporating a portion of it to drynefs, and expofing the ex- traa to a heat fufficient to reduce the lead. Oxidum Plumbi album. (Ed.) c\ Ceruffa. (Lond. Dub.) ^ White oxide of lead. Ceruffe. The white oxide of lead is rnanufaaured in feveral countries. It is prepared by expofing lead to the vapor of vinegar. To ac- celerate the oxidizement, the lead is caft in thin plates, which are rolled up fpirally. A number of thefe are placed perpendicular- ly on a fupport, over a flat veffel containing vinegar, which is con- verted into vapor by a gentle heat, fuch as that of dung. The plates become flowly covered with a white cruft, w hich is in due time removed; and the remains of the plates again expofed to the vapor of vinegar, until they be entirely corroded. White oxide of lead has a fcaly or foliated texture, is brittle, friable, heavy, ofa fnowy whitenefs, and a fweet tafte. It is of- ten adulterated with earthy fubftances, which may be dilcovered by mixing it with oil, aiid reducing the lean in a crucible. In pharmacy the white oxide of lead is only ufed in the compo- fition of ointments and platters. Oxidum Plumbi rubrum. (Ed.) Minium. (Lond.) Red oxide of lead. The preparation of red lead is fo troublefome and tedious, as fcarce ever to be attempted by the apothecary or chemilt; nor in- deed is this commodity expected to be made by them, the prepa- ration of it being a diftina branch of bufinefs. The makers melt large quantities of lead at once, upon the bottom of a reverbera- tory furnace built for this purpofe, and fo contrived, that the flame aas upon a large furface of the metal, which is continually changed by the means of ir«n rakes drawn backwards and for- 284 Materia Media:. [Part II. wards, till the fluidity ®f the lead is deftroyed ; after which, the oxide is only now and then turned. The red oxide of lead is obtained in the form of a very heavy powder, confifling of minute ffiining fcales, of a bright fcai let, verging towards yellow, efpecially it triturated. It is fometimes adulterated with red oxide of iron, red bole, or powdered brick. Thefe frauds are deteaed by the inferiority of color, by mixing it with oil and fubjeding it to the teft of reduaion ; and by its form- ing a black precipitate with tinaure of galls when diffolved in ni- trous acid. Oxidum Plumbi semivitreum. (Ed.) Lithargyrus. (Lond. Dub.) t Semivitrified oxide of lead. Litharge. If oxidized lead be urged with a hafty fire, it melts into the appearance of oil, and on cooling concretes into litharge. Great- eft part of the litharge met with in the ffiops, is produced in tbe Durification of filver from lead, and the refining of gold and filver ■Jy means of this metal. According to the degree of fire and other circumftances, it proves of a pale or deep color ; the firft has been commonly called Litharge of Silver, the other Litharge of Gold. The oxides of lead diffolve by heat, in expreffed oils; thefe mixtures are the bafis of feveral officinal plafters and ointments. Lead and its oxides when undiffolved, have no confiderable ef- feas as medicines. Diffolved in oils, they are fuppofed to be (when externally applied) anti inflammatory and deficcative.— Combined with vegetable acids, they are remarkably fo; and taken internally, prove a powerful, though dangerous ftyptic. POLYGALA SENEGA. Radix. (Ed.) Senega. Radix. (Lond. Dub.) Seneka, or Rattlefnake Root. Diadelphia Oclandria.—Nat. ord. Lomentacex. Seneka is a perennial plant, which grows wild in North A- merica, particularly Virginia and Pennfylvania. This root is u- fually about the thicknefs ot the little finger, varioufly bent and contorted, and appears as it compofed of joints, whence it is fup* pofed to refemble the tail of the animal whofe name it bears; a kind of membranous margin runs on each fide, the whole length of the root. The bark is the aaive part of the root. Its tafte is a* firft acid afterwards very hot and pungent. It has no fmell. Its acrimony refides in a refin ; for it is entirely extraaed by alcohol; does not rife in diftillation; and is not deftroyed by keeping. Part. II.] » Materia Medica. 285 It is an aaive ftimulus, and increafes the fo-rce of the circula- tion, efpecially of the pulmonary veffels. It has therefore been foun^ ufeful in typhoid inflammations of the lungs ; but it is apt todifoHer the ftomach, and to induce diaTrhcea. Some have likewife employed this root in hydropic cafes, and not without fuccefs. There are examples of its occafioning a plentiful evacuation by ftool, urine, and perfpiration; and by this means removing the difeafe, after the common diuretics and hy- dragogues had failed. The Senegaro Indians are laid to prevent the fatal effeas of the bite of the rattlefnake, by giving it internally, and by applying it externally to the wound. The ufual dofe of the powder is thirty grain* or more. Externally, it has been advantageoufly ufed as a ftimulating gargle in croup. POLYGONUM BISTORTA. Radix. (Ed.) Biftorta. Radix. (Dub. Lond.) ^ Great Biftort, or Snakeweed. The root. Willd.g. 785. fp. 3. Oclandria Trigynia—Nat. ord. Oleracetr. This plant is perennial, and grows wild in moift meadows in feveral parts of Britain. The root is about the thicknefs of the little finger, of a blackiffi brown color on the out fide, and red- diffi within ; it is writhed or bent vernacularly (whence the name of the plant) with a joint at each bending, and full ot buffiy fibres ; the root of the fpecies here mentidned has, for the moft part, only one or two bendings ; others have three or more. All the parts of biftort have a rough auftcre tafte, particularly the root, which is one of the ftrongeft of the vegetable aftringents. It is employed in all kinds of immoderate haemorrhagies and oth- er fluxes, both internally and externally where aftringency is the only indication. It is certainly a very powerful ftyptic, and is to be looked on fimply as fuch. To the fudorific, antipeflilential, and other virtues attributed to it, it has no other claim than in con- fequence of its aftringency, and of the antifeptic power which it has in common with other vegetable ftyptics. The largeft dofe of the root in powder is one drachm. POLYPODIUM FILIX MAS. Radix. (Ed.) Filix. Radix. (Lond.) Filix. Mas. Radix. (Dub.) Male fern. Male polypody. The root. Cryptogamia. Filices.—Nat. ord Filiees. This fern is perennial, and grows in great abundance in almoft every part ot Britain where the ground is not cultivated. The greateft part of the root lies horizontally, and has a great number of appendages placed clofe to each other in a vertical direaion, while a number «f fmall fibres ftrike downwards. The large root, • 2 86 Materia Medica. Tart. II. j together with its appendages, are to be referved for ufe. The two ends however, are to be cut off, the one being too old and fpongy, the other too new and green. When chewed, its tafte is fomewhat mucilaginous and fweet, and afterwards flightly aftringent and bitter. Its fmell is alfo weak. This root was ufed as an ahthelmintic in the days of Diofcori- des. It gradually became negleaed ; but its ufe was again reviv- ed at different times by Madame Nuffer, Herrenfchwand, and others, who certainly, frequently fucceeded in killing and expel- ling the tasnia, both lata and cucurbitina, by the exhibition of fe- cret remedies, of which the fern powder was, or rather was fup- pofed to be the principal ingredient ; for there is much reafon to believe that the aaive purgatives with which it was always com- bined, were really the remedies which affeaed the cure. The fame, or nearly a fimilar fecret has been bought by differ- ent potentates, and publiffied for the benefit of thofe iuffering un- jder this obftinate difeafe . Even in 1799, a Berlin apothecary, Matthieu, was fo fortunate as to find a purchafer of his fecret in the king of Pruffia. The remedy was tried in three cafes under the infpe£iion of the Medical College, and in all of them fucceeded in expelling the worms, without pain or any other remarkable occurrence. His fecret, and direaions for their exhibition, was publiffied by authority of the College. For forrre days the patient is to be confined to a fpare diet, and to live principally on faked food, bread, foups, and light vegeta- bles. He is then to take a teafpoonful of the following eleaua'- ry every two hours, for two or three days, until he perceive the motion of the worm : R. Limatur. ftanni. Angli. pur. |i, Pulv. rad. filic. maris, gvi. -----femin. cynse, ^fs. -----radic. jalap, refinofae. -----fal. polychreft, ana ^i. M. Fiat, cum mellis communis fufficiente quantitate, eleauarium. He is then to take in the fame manner, the following purga- tive eleauary, until the worms be expelled ; or if that ffiould not happen, he is to fwallow two or three fpoonfuls ot frefh caftor oil, or get a clyfter of the fame. R Pulv. rad. jalap, refinof. -----fal. polychreft, ana 9ii. -----fcammon. Alep. 9i. ----gummi guttae, gr. x. M. Fiat, cum melle communi, eleauarium. Part II.] Materia Medica* 28f The internal folid part of the root only is to be powdered, and the powder ffiould have a reddiffi color ; and as the dofe and ex- hibition of the remedy muft be regulated according to the age, fex, and conftitution ot the patient, it muft be given always under the direaion of an experienced praaitioner. POTENTILLA REPTANS. Pentaphyllum. Radix. (Lond.) Common cinquefoil. Willd. g. xooo.fp. 34. Icofandria Polygamia.—Nat. ord. Seti- ticofa. This plant is perennial, and grows plentifully in hedges, and by road fides. The root is moderately aftringent; and as fuch is fometimes given internally in diarrhoeas and other fluxes, and employed in gargarifms for ftrengthening the gums, &c. The cortical part of the root may be taken in fubftance, to the quantity of a drachm ; the internal part is ro.ifiderably weaker, and re- quires to be given in double the dofe to produce the fame effea; and as we poffefs many more powerful aftringcnts, the cinquefolt is but little ufed. PRUNUS. Willd. g. 982. Icofandrid Monogynia.—Nat. ord. Pomacea. Sp. 29. Prunus Domestica. Fruclus. (Ed.) Prunus Gallica. Fruclus, Prunum Gallicum diclus. (Lond. Dub.) Plumb tree. The fruit. French prunes. This tree is found wild in hedges in England, but has proba- bly originated from the ftones of the cultivated kinds being dropt there by accident. Great quantities of the dried fruit are import- ed from the Continent, but the French prunes are reckoned the beft. They contain much mucilaginous and faccharine matter, and their medical effeas are, to abate heat, and gently loofen the bel- ly ; which they perform by lubricating the paffages, and foftening the excrement. They are of confiderable fervice in coftivenefs, accompanied with a heat or irritation, which the more ftimulat- ing cathartics would tend to aggravate ; where prunes are foot of themfelves fufficient, their aaion may be promoted by joining with them a little rhubarb or the like ; to which may be added fome carminative ingredient to prevent their occafioning flatulency. Sp. 32. Prunus Spinosa. Prunusfylveflris. Fruclus. (Lond.) The floe tree. The fruit. %88 Materia Medica. [Part II. The floe alfo grows wild in Britain. The fruit has a very aftringent fouriffi tafte. It contains malic acid. The infpiffated juice of the unripe fruit is very aftringent, and is called Acacia Germanica. An infufion of a handful of the flowers is a fafe and* eafy purge. The powdered bark will fometimes cure agues. PTEROCARPUS. Diadelphia Decandria.—Nat. ord. Papilionacea. Sp. Pterocarpus Santalinus. Lignum. (Ed.) Santalum rubrum. Lignum. (Lond. Dub.) Red Saunders. The wood. This tree grows in the Eaft Indies, and acquires a very large fize. The wood is brought in large billets, of a compaa texture, a dull red, almoft blackiffi color on the outfide, and a deep brighter red within. It has no manifeft fmell, and little or no tafte. It communicates a deep red to reaified fpirit, but gives jno tinge to aqueous liquors j a fmall quantity of the refin, ex- traaed by means of fpirit, tinges a large one of freffi fpirit, ot an elegant blood red. The principal ufe of red faunders is as a coloring drug; with which intention it is employed in fome formulae, particularly in the tintlura lavandula compofitai Sp. Pterocarpus Draco. Refina. (Ed.) Sanguis Draconis. Refina. (Lond.) Dragon's blood. A refin. This is alio a very large tree. It is a native of South Amer- ica, and the refin which exudes from incifions made in its bark ufed to be frequently fent from Carthagena to Spain. It is how- ever doubtful, if the dragon's blood of the ffiops be produced from this tree, as many others furnifh a fimilar refin, as the Dra- caena draco, Dalbergia monetaria, and efpecially the Calamus draco, which probably furnifhes all that is brought from the Eaft Indies. The beft dragon's blood is not in cakes, but is brought in fmall maffes, of the fize of a nutmeg, wrapt up in the dried leaves of fome kind of reed, breaks fmooth, free from any vifible impuri- ties, of a dark red color, which changes, upon being powdered, into an elegant bright crimfon ; readily melts and catches flame, and is not a£ted on by watry liquors. It totally diffolves in pure fpirit, and tinges a large quantity of the menftruum ofa deep red color, it is likewife foluble in expreffed oils, and gives them a red hue, lefs beautiful than that communicated by anchufa. This drug in fubftance, has no fenfible fmell or tafte ; when diffolved, it difcovers fome degree ot warmth and pungency. Part II.] Materia Mejlica. 289 PULEGIUM. (Lond. Dub.) See Mentha. PUN1CA GRANATUM. Cortex frudus. Flores pleni, Balauftia dicli. (Ed.) Granatum. Floris petalum, Balauftium diclum. Fruclus Cortex: (Lond.) Flores, Balauftia dicli. Pericarpii cortex. (Dub.) Pomegranate. The outer rind of the fruit. The double flow- ers, called Balauftine. Willd. g. y8o. fp. x. Icofandria Monogynia.—Nat. ord. Po- maceae. The pomegranate is a low tree, or rather ffirub, growing wild m Italy and other countries in the fouth of Europe ; it is fome- times met with in our gardens ; but the fruit, for which it is chief- ly valued, rarely comes to perfeaion. This fruit has the general qualities of the other fweet fummer fruits, allaying heat, quench- ing thirft, and gently loofening the belly. The rind is a ftrong aftringent, and as fuch is occafionally made ufe of. The flowers are otan elegant red color, in appearance refembling a dried red rofe. Their tafte is bitteriffi and aftringent. They are recom- mended in diarrhoeas, dyfenteries, and other cafes where aftrin- gent medicines are proper. .. PYRETHRUM. (Lond. Dub.) See Anthemis. PYRUS CYDONIA. Cydonia Malus. Fruclus ejusque femen. (Lond.) The quince. The fruit and feeds. Willd. g. 992. fp. 17—Icofandria Pentagynia.—Nat. crd. Po- macea. , - The quince is originally a native of Crete, but ripens its fruit perfeaiy in England. Quinces have a very auftere acid tafte; taken in fmall quan- tity, they are fuppofed to reftrain vomiting and alvine fluxes ; and more liberally, to loofen the belly. The feeds abound with a mucilaginous fubftance of no particular tafte, which they readily impart to watery liquors ; an ounce will render three pints of water thick and ropy like the white of an egg. QUASSIA. Willd. g. 849. Decandria Monogynia.—Nat. ord. Gruinales. Sp. 2. QuassiaSimaruba. Cortex. (Ed.) Simarouba. Cortex. (Lond.) Cortex, lignum. (Dub.) Mountain or bitter damfon. The bark. This tree grows in Guiana and in Jamaica. The fimaroubaof the ffiops is the bark of the root of this tree, and not of the quaifia amara, as ftated by the Dublin College. It is brought to ws in 290 Materia Medica. [Part II. pieces fome feet long, and fome inches broad, folded lengthwife. It is light, fibrous, very tough ; of a pale yellow on the infide ; darker colored, rough, fcaly and wartedon theoutfide ; has little fmell, and a bitter not difagreeable tafte. It gives out its bitter- nefs both to alcohol and water. It has been much celebrated in obftinate diarrhoea, dyfenterv, anorexia, indigeftion, lienteria, and intermittent fevers; but it is doubtful that it is better than other bitters. It is given in powder, in dofes of half a drachm or a whole drachm; but it is too bulky, and very difficultly pulverizable. It is beft exhibited in decoction. Two drachms ot the bark may be boiled in two pounds of water to one, and the decoaion drunk in cuujFuls in the courfe of the day. Sp. 3. Quassia Excelsa. Lignum. (Ed.) Quaffia. Lignum, Cortex, Radix. (Lond.) Quaffia. The wood, bark, and root. This tree grows in Jamaica, and in the Caribaean iflands. The quaffia of the ffiops is the wood of its root, and not of the quaffia amara, which is a very rare tree, but furpaffes all others in bit- ternefs . This root is about the thicknefs of a man's arm ; its wood is whitiffi, becoming yellowiffi by expofure to the air. It has a thin, grey, fi flu reel, brittle bark, which is deemed in Surinam more powerful than the wood. Quaffia has no fenfible odour, but is one of the moft intenfe, durable, pure bitters known. Its infu- fion, decoaion, and tinaure, are almoft equally bitter and yellow- iffi, and not blackened by ehalybeates. It is a very pure and fimple bitter, and may be given in all cafes where bitters are proper. It has been exhibited in intermit- tent and bilious fevers, in ftomachic complaints, in lienteria, in cachexy, dropfies, leucorrhcea, and gout. It is much ufed in this Country to givo the bitternefs to malt liquors, though it fubje&s thofe brewers who employ it to a very heavy penalty. It can fcarcely be reduced to a fufficiently fine powder to be given in fubftance, and is therefore generally given in the formef infufion, decoaion or extraa. QUERCUS. Monoecia Polyandria.—Nat. ord. Anuntacea. Sp. Quercus Robur. Cortex. (Ed.) Ouercus. Cortex. (Lond. Dub.) Oak. The bark. The oak grows wild in Britain. The fuperior excellence of its wood for ffiip building has rendered its cultivation an objeft Part II.] Materia Medica. 291 of national concern. Its faw dull is an ufeful dye fluff, and its bark is the principal article ufed in tanning. The bark is a ftrong aftringent ; and is recommended in hae- morrhagies, alvine fluxes, and other preternatural or immoderate fecretions. In thefe it is fometimes attended with good effeas. But it is by no means capable of being employed as a fubftitute, in every inftance, for Peruvian bark, as fome have afferted ; and indeed it is fo difficultly reduced to a fufficient fine powder, that it can fcarcely be given internally in fubftance. Sp. Quercus Cerris. Cymphis nidus. (Ed.) Galla. (Lond.) Gallce, Cynipidum nidi. (Dub.) Oriental oak. The neft ot thecynips quercifolii. This fpecies of oak is a native of the Levant, and of the warm- er countries ot Europe. The cynips quercifolii, a hymenoplerous infea, depofits its eggs in the leaves and other tender parts of the tree. Around each pun£lure an excrefcence is prefently formed, within which the egg is hatched, and the infe6l paffes through all the fiacres of its metamorphofis, until it become a perfea infea, when it eats its way out of its prifon. Thefe excrefcences are called galls, or gallnuts. They are ot different fizes, fmooth or knotty on the furface, ot a whitiffi, reddiffi, or blackiffi color, and generally pen- etrated with a fmall hole. Internally they confift of a fpongy, but hard, more or lefs brown fubftance, and thev have a very rough aftringent tafte. Good galls are of a blackiffi grey or yel- low color, heavy, and tubercuJated on the furface. They are the moft powerful aftringents we poffefs, but are feldom ufed in me- dicine. RAPHANUS RUSTICANUS. (Lond. Dub.) See Coch- learia ARMORACIA. RESINA ALBA. (Dub.) See Pinus. RHABARBARUM. (Lond. Dub.) See Rheum. RHAMNUS CATHARTICUS. Baccarumfuccus. (Ed.) Spina Cervina. .Bacca. (Lond.) Purging buckthorn. The berry. The juice of the berries. Willd. g. 405. fp. 1. Pentandria Monogynia.—Nat. ord. Da- rn ofa. This tree, or buffi, is common in hedges ; it flowers in June, and ripens its truit in September or the beginning of Oaober. In our markets, the fruit of fome other trees, as the blackberry bear- ing alder, and the dog berry tree, have of late been frequently mixed with or fubftituted for thofe of buckthorn. This abufe 3£>2 Materia Medica. [Part II. may be difcovered by opening the berries ; thofe of buckthorn have almoft always four feeds, the berries of the alder two, and thofe of the dog berry only one. Buckthorn berries, bruifed on white paper, ftain it of a green color, which the others do not. Thofe who fell the juice to the apothecaries, are faid to mix it with a large proportion of water. Buckthorn berries have a faint difagreeable fmell, and a naufe- ous bitter tafle. They have long been in confiderable efteem as cathartics ; and celebrated in dropfies, rheumatiftris, and even in the gout ; though in thefe cafes they have no advantage above other purgatives, and are more offenfive, and operate more fevere- ly, than many which the ffiops are furniffied with ; they general- ly occafion gripes, ficknefs, dry the mouth and throat, and leave a thirft of long duration. The dofe is about twenty ot the frefh berries in fubftance, and twice or thrice-this number in decop- tion ; an ounce of the expreffed juice, or a drachm of the dried- berries. RHEUM PALMATUM. Radix. (Ed.) Rhabarbarum. Radix. (Lond. Dub.) Palmated rhubarb. The root. Willd. g. 808.7^. 5. JLnneandria Monogynia.—Nat. ord. Ole- racea. This plant grows fpontaneoufly in China, and endures the colds of our climate. But it is not afcertained that the Chinefe or Ruffian rhubarb is the dried roet of this plant. Pallas thinks that it is obtained in- difcriminately from the rheum undulatum, palmatum, and com- paaum, more efpecially from the firft ; while Mr. Sievers, an apothecary who was fent by Catherine II, on purpofe to obtain the true rhubarb plant, and travelled for feveral years in the countries contiguous to that whence the rhubarb is brought, is of opinion, that the botanical charaaers of the plant which furnifhes it are ftill unknown, excepting that it is faid not to grow to a great fize, and to have round leaves, which are toothed on the edges with almoft fpinous points. All the rhubarb of commerce is brought from the Chinefe town Sini or Selim, by the Bucharians. It grows on the neighboring chain of lofty mountains which ftretches to the lake Koko Nor, between 3,5° and 40° north latitude. It is dug up by the poor peafants, cleaned from the earth, cut in pieces, ftrung with the bark on firings, and expofed dry under cover in the ffiade for a whole year, before it Ts again cleaned and prepared for exporta- tion. There is a diftinaion made in commerce between the Ruffian and Chinefe rhubarb, although they both come from the fame country. Part II.] Materia Medica. 293 The Ruffian is dearer, and always good, as very great atten- (i©n is paid both in purchafingand tranfporting it, by order of the goyernrnent. In Kiachta, on the Ruflian frontier, it is received from the Bucharians by a Ruffian apothecary, who examines it. The bad is immediately burnt, and the good is i'reed from its bark, woody parts, and every impurity, in the moft careful man- ner. It is. then fent to Mofcow and to Peterfburgh, where it is again examined. It is commonly in round pieces, ofa reddiffi or whitiffi yellow color, feels gritty between the teeth, and is often perforated with fo large a hole, that many pieces have the appearance ofa bark. The Chinefe or Eaft India rhubarb is brought by fea from Canton. It is heavier, harder, and more compact than the other ; feldom perforated with holes, and either in long pieces, or with two flat fides, as if they had been compreffed. The general characters of good rhubarb are, its having a whit- iffi or clear yellow color, being dry, folid, and compafct, moder- ately heavy ; brittle ; when recently broken appearing marked with yellow or reddiffi veins, mixed with white ; being eafily pul- verizable ; forming a powder of a fine bright yellow, having the peculiar, naufeous, aromatic fmell ot rhubarb, and a fubacrid, bit- teriffi, fomewhat aftringent tafte, and when chewed feeling gritty under the teeth, fpeedily coloring the faliva, and not appearing ve- ry mucilaginous. The fize and form of the pieces are ot lit- tle confequence ; only we muft break the large ones, to fee that they are not decayed ©r rotten within ; and we muft alfo obferve, that they are not mufty or worm eaten. This is the more necef- fary, as damaged pieces are frequently fo artfully dreffed up, and colored with powdered rhubarb as to impofe on the buyer. The principle conftituent of rhubarb is extraaive matter, folu- ble both in alcohol and in water. By gentle decoaion, it lofes above one half its weight. Rhubarb alfo contains fome volatile odorous matter, on which its peculiar naufeous fmell and its aaiv- ity as a purge depend ; for when diffipated, either by age or any preparation to which the rhubarb has been fubjeaed, the powers of the medicine are almoft deftroyed. It alfo contains fome tan- nin, and aboUt one fixth of its weight of oxalate of lime. Rhubarb is a mild cathartic, which operates vyithout violence or irritation, and may be given with fafety even to pregnant women, and to children. In fome people, however, it occafions fevere griping. Befides its purgative quality, it is celebrated as an af- tringent, by which it itrengthens the tone of the ftomach and in- teftines, and proves ufeful in diarrhoea and diforders proceeding from laxity. Rhubarb is exhibited, 1. In fubftance, in the form of powder. It operates more powerfully as a purgative in this form than in any other. Tht 6^3 294 Materia Medica. [P"rt. 1]- dofe for an adult, is about a fcruple or upwards. On account of its crreat bulk, it is lometimes unpleafant to tai^e, and its laxative effects are often increafed by the addition ot neutral falts, or oth- er more aaive purgatives. In fmaller dofes it often proves an excellent ftomachic. 2. In infufion. Rhubarb yields more of its purgative property to water than to alcohol. The iniufion is however, confiderably weaker than the powder, and requires double the dofe to produce the fame effea. It is well adapted for children, but muft be al- ways frefh prepared. 3. In tinaure. On account of the ftimulating nature of the menftruum, this preparation frequently cannot be exhibited in do- fes large enough to operate as a purgative. Its principal ufe is as a tonic and ftomachic. The virtues of rhubarb are deftroyed by roafting, boiling, and in forming the extraft. RHODODENDRON CHRYSANTHUM.^ Folia. (Ed.) Yellow flowered rhododendron. The leaves. Willd'. g. 867. fp. 7. Decandria Monogynia.—Nat. ord. Bi- cornes. This fmall ffirub grows in the coldeft fituations, and higheft parts of the fnow covered mountains in Eaft Siberia, and efpec- ially in Dauria. The ieaves are oblong, rigid, refleaed at the edges, rough on the upper furtace, fmooth and paler on the low- er. When dried, they have no fmell, but a rough, aftringent, and bitteriffi tafte. They alfo contain a ftimulant, narcotic princi- ple ; for they increafe the hsat ot the body, excite thirft, and pro- duce diaphorefis, or an increafed difcharge of the other fecretions or excretions ; and in a larger dofe, inebriation and delirium. The Siberians ufe a decoction of it in rheumatifm and gout. They put about two drachms of the dried fhrub in an earthern pot, with about ten ounces of boiling water, keeping it near a boiling heat for a night, and this they take in the morning. Befides its other effeas, it is faid to produce a fenfation of prickling or creep- ing in the pained parts ; but in a few hours the pain and difagree- able fymptoms are relieved, and two or three dofes generally complete the cure. The ufe of liquids is not allowed during iis operation, and this is apt to produce vomiting. RHUS TOXICODENDRON. Folia. (Ed.) Poifon oak. The leaves. Willd. g. 566.fp. xj. Pentandria Trigynia.—Nat. ord. Du- mofie. This is a deciduous ffirab of moderate growth, a native of North America. The leaves are alternate, and ftand upon very long leaf ftalks. Each leaf confifts of three leafits. It is faid that Part II.] Materia Medica. 295 its juice is fo extremely acrid as to caufe inflammation,and fome times even fphacelation, in the parts touched with it. It was firft tried as a medicine by Dr. Alderfon of Hull, in imitation of the experiments ot M. Frefnoi with the rhus radicans. He gave it in four cafes of paralyfis, in dofes of half a grain, or a grain, three times a day, and all his patients recovered, to a certain de- gree, the ufe of their limbs. The firft fymptom of amendment was always an unpleafant feeling of prickling or twitching in the paralytic limbs. We have given it in larger dofes without experiencing the fame fuccefs. It was not, however, inaaive. In one cafe the patient difcontinued its ufe on account ot the dif- agreeable prickling it occafioned ; and in general it operated as a gentle laxative, not withftanding the torpid ftate of the bowels of fuch patients, R1BES. Willd.g. 445. Pentandria Monogynia.—Nat.ord. Pomacea. Sp. x. Ribes Rubrum. Fruclus. (Lond. Dub.) Red currant. 7'he fruit. This ffirub grows wild in England, and is very generally cul-. tivated for the fake of its pleafant fub acid fruit. The juice of the fruit contains faccharine matter, malic, and citric acids, and a fubftance fcarcely foluble in cold water, very foluble in hot wa- ter and coagulating into the form of a jelly as it cools. By boil- ing currant juice with a fufficient quantity of fugar to abford the acid watery parts, the whole forms on cooling, an uniform jelly, which is often ufed as an acid demulcent in fore throats, and diffolved in water, forms a pleafant cooling drink in feverifh complaints. Sp. 8. Ribes Nigrum. Fruclus. (Lond. Dub.) Blackcurrant. The fruit. This is alfo a native ffirub, which is likewife frequently cul- tivated for the fame purpofes with the former variety, and indeed is preferred to it for Medical ufe. R1C1NUS COMMUNIS. Semen, et ejus oleum fixum. (Ed.) Seminis oleum. (Lond.) oleum efeminibusexpreffum. (Dub.) Monecia Monadelphia.—Nat. ord. Tricocea. PalmaChrifti. The feeds and the fixed oil obtained trom them. This plant grows in both Indies, Africa, and the fouth of Eu- rope. It is of fpeedy growth, and in one year arrives at its full height, which feldom exceeds twenty feet. The capfules are prickly and triangular, and contain, under a thin, dry. grey, and black marbled hufk, a white oily kernel. The fkin is extremely 2-96 Materia Medica. [Part II. acrid ; and one or two of the feeds fwallowed entire, operates as a draftlc purgative or emetic. The kerne is yield almoft a fourth part of their weight of a blar.d oxpd oil, commonly called Caftor Oil. It is obtained from th ro either by evpreffion, or by decoaion with water. The for- mer me.hod is prafclifed in Europe, the latter in Jamaica. To increafe the oroc'u-ft, it is common to parch the feeds over the fire before •[.•.*? ■•. extra ted from them ; but the oil thus obtained v* in'lerior to that pri-paird by cold expreffion or fimple decofction, Dftn s's^apt to''j.-: Mine rancid. genuine caftor oil is thick and vifcid, of a whitiffi color, in- f.pi"1 or fveetifh to the tafte, and without fmell. A.s a ?;.edicine; it is a- ;.M'le *r.d uleful purgative ; it in gener- al produces its jffecis without griping, and may be given with fafety w ie acrid purgatives are improper, as in colic, calculus, gc u.iicea, &c. ; fome likewife ufe it as a purgative in worm- ca'e.s. Half an ounce or an ounce commonly anfwers with an adult, and a drachm or two with an infant. With many, the averfion to oil is fo great, that this purgative cannot be taken without great reluaance; and accordingly differ- ent mpdesof taking it have been propofed. Some prefer taking it fwimming on a glafs of water or peppermint water, or in the form of emulfion, with mucilage, or with the addition of a little rum. ROSA. ^ Willd. g. 907. Icofandria Pologynia.—Nat. ord. Senticofa. Sp. 16. Rosa Gallic a. Petala. (Ed.) Rofa rubra Petala. (Lond. Dub.) Red rofe. The petals. This has not the fragrance of the fucceeding fpecies ; but the beautiful color ot its petals, and their pleafant aftringency, have rendered them officinal. Sp. 17. RosaDamaseeMa. Petala. (Lond. Dub.) Rofa centifolia. Petala. (Ed.) Darnafk rofe. The petals. The native country of this ffirub is unknown, but the delight- ful fragrance of its flowers has rendered it the favorite ornament of every garden. In the former editions of Linnaeus, the damafk rofe was confidered as a variety only of the rofa centifolia; but Aiton, Du Iloi and Wiidenow have arranged it as a diftina fpe- cies. It is howcer highly probable, that the petals of all the varieties of the rof- centiioiia, or Dutch hundred leaved rofe, Wil'denbvv's 15th fpecies, are employed indifcriminately with thofe of the real damafk rofe in the diftillation of rofe water. Part. II.] Materia Medica. 597 Sp. 31. Rosa Canina. Fruclus recens. (Ed.) Cynofbatus. Fruclus. (Lond.) Dog rofe. The fruit called Heps. This fhrub is found in hedges throughout Britain. The pulp of the fruit, befides faccharine matter, contains citric acid, which gives it an acid tafte. The feeds, and ftiff hair with which they are furrounded, muft be carefully removed from the pulp before it can be ufed. ROSMARINUS OFFICINALIS. Summitates fiorentes. (Ed.) Rosmarinus. Cacumen, flos. (Lond.) Rofmarinus. Herba. (Dub.) Rpfemary. The herb and flowers. Willd.g. 62. fp. x. Diandria Monogynia,—Nat. ord. Verticil- lata. Rosemary is a ffirubby perennial, which grows wild in the fouth of Europe, and is cultivated in our gardens. It has a fra- grant fmell, and a warm pungent bitterifh tafte, approaching to that of lavender ; the leaves and tender tops are ftrongeft ; next to thefe the cup of the flower ; the flowers themfelves are con- fiderably the weakeft, but moft pleafant. Its virtues depend entirely on its effential oil, which feems to be combmed with camphor, not only from its peculiar tafte, but from its poffefling chemical properties, which depend on the pre- fence ot camphor ; and from its depofiting cryftals of camphor when long kept. RUBIA TINCTORUM. Radix. (Ed.) Rubia. Radix. (Lond. Dub.) Madder. The root. Willd.g. ^Sy.fp. x. Tetrandria Monogynia.—Nat. ord. Stel- lata. Madder is perennial, and grows wild in fome parts of Brit- ain, but the dyers are principally fupplied with it from Zealand, where it is cultivated in large quantities. The roots confift of articulated fibres, about the thicknefs of a quill, which are red throughout, have a weak fmell, and a bitter- iffi aftringent tafle. For the ufe of the dyers, they are firft peel- ed and dried, then bruifed and packed in barrels. Madder pof- feffes the remarkable property of tinging the urine, milk and bones of animals, which are fed with it, of a red color. It is faid to be ufeful in the atrophy of children, and fome be- lieve in its reputed powers as an emmenagogue. It is given in fubftance in dofes of halt a drachm, feveral times a day, or in deco6tion. 293 Materia Medica. [Part II. RUBUS ID^EUS. Fruclus. (Lond. Dub.) Rafpbeny. The fruit. Willd. g. 998- fp. 4. Icofandria Polygynia.—Nat. ord. Se.iti- cofa. This ffirub is found wild in Britain, and is much cultivated for the fake of its pleafant fubacid fruit, which contains both ni- tric and malic acids. RUMEX ACETOSA. Folia. (Ed.) Acetofa pratenfis. Folia. (Lond,) Acetofa. Folia. (Dub.) Sorrel. The leaves. Willd.g. 6gg.fp. gi. Hexandria Trigynia.—Nat. ord. Olera- cea. Sorrel is a perennial plant, which grows wild in fields and meadows ihroughout Britain. The leaves have an aftringent acid tafte, without any fmell or particular flavor ; their medical effeas are, to cool, quench thirft, and promote the urinary dif- charge ; a decoaion of them in whey affords an ufeful and agree- able drink in febrile or inflammatory diforders. All thefe effeifsarcto be afcribed entirely to the fuper oxalato of potafs which they contain. RUTA GRAVEOLENS. Herba. (Ed.) Rata. Herba. (Lond.) Folia. (Dub.) Rue. The herb. Willd. g. 927. fp. 1. Decandria Monogynia.—Nat. ord. Mu(-> tifiliqua. This is a fmall ffirubby plant, a native of the fouth of Europe, and cultivated in our gardens. Rue has a ftrong, ungrateful fmell, and a bitteriffi, penetrating tafte ; the leaves when in full vigor, are extremely acrid, info- much as to inflame and blifter the fkin, if much handled. With regard to their medical virtues, like other remedies, of which the aaive conftituent is an effential oil, they are heating and ftim- ulating, and hence fometimes are ferviceable iu fpafmodic affec tions, and cafes of obflrucled fecretions. SABINA. (Lond. Dub.) See Juniperus. SACCHARUM OFFIC1NARUM. a. Saccharum non purificatum. (Lond. Ed.) Saccharum rubrum. (Dub.) b. Saccharum purificatum. (Lond. Dub.) Saccharum punf fimum. (Ed.) c. Sacchaii rubri fyrupus, (Dub.) Part II.] Materia Medica. ^9 Sugar cane. Raw or brown fuoar. Double refined fuear.— Molaffes. Willd. g. 122. fp. 4. Triandria—Digynia. Nat. ord. Grainina. The fugar cane grows wild in both Indies, and forms ike principal objea of cultivation in the Weft Indies. Sugar, of which we have already (256) noticed the general properties, is principally obtained from this plant, by boiling down its expreffed juice, with the addition ofa certain proportion of lime or potais, until the greater part is difpofed to concrete into browmlh or yellowiffi cryftalline grains. The lime or potafs is added to fat urate fome malic acid, whofe prefence impedes the cryftallization. The molaffes, or that portion of the infpiffated juice which does not cryftallize, is feparated from the raw fugar, which is fent to Europe to be refined. This is performed by diffolving it in wa- ter, boiling the folution with lime water, clarifying it with blood or white ot eggs, and ftraining it through woollen bags. The fo- lution, after due evaporation, is permitted to cool to a certain de- gree, and then poured into conical forms of unglazed earthern ware, where it concretes into a mafs of irregular cryftals. The fyrup which has not cryftallized is then permitted to run off through a hole in the apex of the cone. The upper or bioad end of the cone is then covered with moift clay, the water of which gradually penetrates into the fugar, and difplaces a quantity of fyrup, which would otherwife be retained in it, and diiv.oior it. It is then carefully dried, and gets the name of loaf or lump fugar. When the folution and other fteps of the procefs are repeated, the fugar is faid to be double refined. Sugar is fometimes made to affume a more regular form of cryftallization, by carrying the evaporation only a certain length and then permitting the fyrup to cool flowly. In this form it is called White or Brown Sugar Candy, according to the degree of its purity. Molaffes or treacleis a very impure fyrup. It is thick, vifcid, of a dark brown, aimoft black color, and has a peculiar fmell, and a fweet, fomewhat empyreumatic tafle. Treacle is applied to many domeftic and economical purpofes ; and inhofpital praaice may fuperfede the ufe of fugar in many inftances. Raw fugar varies very much in quality. It ffiould be dry, cryftallized in large fparkling grains, of a whitifh or clear yellow color without fmell, and of a fweet tafle, without any peculiar flavor. Refined fugar ffiould have a brilliant white color, and a clofe compaa texture. It ffiould be very hard, but brittle, aiid break with /harp femi tranfparent, fplintery fragments. Sugar, from being a luxury, has now become one of the neccf- faries of life. SO© Materia Medka. [Part II. In Europe, fugar is almoft folely ufed as a condiment. But it is alfo a very wholefomeand powerful article of nourifhment; for during .crop time, the negroes in the Weft Indies, notwithftanding their increafed labors, always grow fat. It is in this way alfo that its internal employment is ufeful in fome difeafes, as in fea fcurvy ; for fugar produces no particular effea as a medicine, ex- cept that the coarfer and impure kinds are flightly purgative. Ap- plied externally, it aa« as an efcharotic in fpongy and unhealthy granulations ; and to abraded or inflamed furfaces it proves gent. ly ftimulant. In pharmacy it is principally employed to cover bad faftes, to give form, and to pie ferve more aaive fubftances. In ufing it for the laft purpofe, we muft always remember, that if the proportion of fugar employed be too final!, it will promote inftead of retarding the fermentation of the articles it intended to preferve. SAGAPENUM. Gummi refina. (Lond. Dub. Ed.) Sagapenum. A gum refin. The plant which furrrifhes this fubftance is not afcertained. but is conjeaured by Wrilldenow to be the Ferula Perfica. Sacrapcnum is a concrete juice brought from Alexandria, either in diftina tears, or agglutinated in large maffes. It is outwardly ofa yellowiffi color ; internally, fomewhat paler, and clear like horn : It grows foft upon being handled, and fticks to the fingers; its tafte is hot, naufeous and bitteriffi, and its fmell difagreeable and alliaceous. It is not fufible ; is fparingly foluble in alcohol; almoft entire- ly foluble in water; and affords a fetid effential oil by diflilla- tion. In medical virtues it holds a kind of middle place between affa- foetida and galbanum, and may be employed in the fame manner, and under fimilar circumftances. SAL AMMONIACUS. (Lond. Dub.) See Murias Am- monite. SAL COMMUNIS. (Dub.) SAL MURIATICUS. (Lond.) See Murias Soda. SALIX FRAGILIS. Salix. Cortex. (Dub.) Crack willow. The bark. Dioecia Diandria.—Nat. ord. Atnentacea. This willow grows wild in England. The bark poffeffes a confiderable degree ot bitternefs and aftringency. It has been recommended by fome as a fubftitute for the Peruvian bark ; and ot the indigenous barks which have been propofed, it is perhaps Part II.] Materia Medica. 301 one ot the moft effeaual. But in point of efficacy it is in no de- gree to be compared with the Peruvi&n bark. SALVIA OFFICINALIS. Folia. (Ed.) Salvia. Folium. (Lond. Dub.) Sage. The leaves. Willd. g. 63. fp. 7. Diandria Monogynia.-—Nat. ord. Verticil- lata. Sage is a perennial plant, a native of the fouth of Europe, and cultivated in our gardens. There, are feveral varieties of it, dif- fering in fize, or in the color of its flower, but their properties are the fame. They have a peculiar aromatic fmell, and a warm, aromatic tafte, with fome degree of bitternefs and altringehcy. In its effeas fage agrees with other aromatics. It is ftimulant, carminative and tonic. In cold phlegmatic habits, it excites appetite, and proves fer- viceable in debilities of the nervous fyftem. The beft preparation for thefe purpofes is an infufion of the dry leaves, drunk as tea ; or a tinaure, or extraa, made with reaified fpirit, taken in pro- per dofes ; thefe contain the whole virtues of the fage ; /he diftil- led water and effential oil, only its warmth and aromatic quality, without any of its roughnefs or bitternefs. Aqueous infufions of the leaves, with the addition of a little lemon juice, prove an ufe- ful diluting drink in febrile diforders, being fufficiently agreeable to the palate. SAMBUCUS NIGRA. Flores, Bacca, Cortex. (Ed.) Sambucus. Cortex interior, Flos, Bacca. (Lond. Dub.) Common elder. The inner bark, flowers and berries. Willd.g. tfog.fp. 3. Pentandria Trigynia.—Nat. ord. Dumofie. This tree is frequent in hedges ; it flowers in May, and ripens its fruit in September. The inner green bark of its trunk is gently cathartic. An infufion of it in wine, OY the expreffed juice in the dofe of half an ounce or an ounce, is faid to purge moder- ately, and in fmall dofes to prove an efficacious deobftruent capa- ble of promoting all the fluid fecretions. The young buds, or rudiments of the leaves, are ftrongly purgative, and aa with fo much violence as to be defervedly accounted unfafe. The flowers are very different in quality ; thefe have an agreeable aromatic flavor, which they yield in diftillation with water, and im- part by infufion to vinous and fpirituous liquors. The berries contain malic acid, and have a fweetiffi. not unpleafant tafte ; nev- erthelefs, eaten in fubftance, they offend the ftomach ; the ex- preffed juice, infpiffated to the confiftence of a rob, proves an ufeful aperient medicine ; it opens obftruaions ot the vifcera, promotes the naturalevacuations, and, if continued for a length of time, does oonfiderable fervice in fundry chronical diforders. 202 Materia Medica. [Part If. SANTALUM RUBRUM. (Lond. Dub.) See Ptero- CARPUS SANTALINUS. SANTONICUM. (Lond. Dub.) See Artimisia. SAPO. Sapo ex oleo olivarum et foda confeclus. (Ed.) Sapo ex ole« oliva et natro confeclus. (Lond.) Sapo durus Hifpanicus. (Dub.) Th e general chemical properties of foap have been already no- ticed (243.) The only fpecies which is officinal in our Pharma- copoeias, is that compofed of olive oil and foda. It is only pre- pared in the countries which produce the oil. For medicinal ufe we prefer the Spaniffi. . It ffiould be white and hard, diffolve entirely in water and in alcohol, forming with the former a milky, and with the latter a tranfparent folution, the folutions ffiould froth freely on agita- tion. It ffiould not be variegated in its color, feel greafy or moift, or be covered with a faline efflorefcence ; and the folutions ffiould not have a rancid fmell or tafte. Some of the foreign difpenfa- tories are fo very particular about the nature of the foap ufed in medicine, as to direa it to be prepared by the apothecary, by fim- ply triturating, without the affiftance of heat. Provence oil, with half its weight of a folution of foda, of the fpecific gravity of 1.375, until they unite. Soap is decompofed by all the acids, earths, and earthy and metalline falts. The acids combine with the alkali, and feparate the oil. The earths form an infoluble earthy foap with the oil, and feparate the alkali, while with the falts there is a mutual de- compofition, the acid combines with the alkali, and earthy or me- talline foaps are formed. The detergent property of foap, or the power it poffeffes of rendering oily and refinous fubftances mifcible with water, has given rife to very erroneous notions of its medical virtues. It was fuppofed to render fuch fubftances more readily foluble in the juices of the ftomach, and in the fluids of the body, and to be well fitted for diffolving fuch oily or unauous matters as it may meet with in the body, attenuating vifcid juices, opening obflruc- tions ©f the vifcera, and deterging all the veffels it paffes through. It has likewife been fuppofed a powerful menftruum for the uri- nary calculus; and a folution of foap in lime water, has been con- fidered as one of the ftrongeft diffolvents that can be taken with fafety into the ftomach : For the virtue of this compofition has been thought confiderably greater than the aggregate of the diffolving powers of the foap and lirne water when unmixed. How erroneous thefe ideas are, appears evidently, when we recollea the very eafy decompofition of foap, which renders i' Part II.] Materia Medica, 303 perfeaiy impoffible that it ffiould enter the circulating fyftem, or indeed come into contaa with the fluids of the mouth, without being decompofed. As to the folution of foap in lime water, we may obferve, that it is only a clumfy way of exhibiting a folu- tion of foda; for the foap is decompofed, an infoluble foap of lime is formed, and the foda remains in folution. The internal ufe of foap ffiould therefore be confined, in our opinion, to the giving form to other fubftances which are not decompofed by it, and to decompofe metallic poifoni when they have been taken in- to the ftomach. For this laft purpofe, a teacupful ofa folution of foap, in four times its weight of water, may be drunk every three or tour minutes, until a fufficient quantity be taken. Applied externally, it is a very powerful detergent, and com- bines the flimulating properties of the alkali with the lubricitat- ing nature of the oil. In this way it often proves a powerful dif- cutient and a ufeful application to fprains and bruifes. SARCOCOLLA. Gummi refina. (Lond.) Sarcocolla. This is a concrete juice, brought from Perfia and Arabia in fmall, whitiffi, yellow grains, with a few of a reddiffi, and fome- times of a deep red color, mixed with them ; the whiteft tears are preferred, as being the freffieft. It is fuppofed to be the pro- dua of the Penasa Sarcocolla, Willd. g. 21S. fp. 1. Tetrandria Monogynia.—Nat. ord. Conglomerata- Its tafte is bitter, accom- panied with a dull kind of fweetnefs. It diffolves in watry liquors, and appears to be chiefly of the gummy kind, with a fmall admix- ture of refinous matter. SARSAPARILLA. (Lond. Dub.) SeeSMiLAx. SASSAFRAS. (Lond. Dub.) See Laurus. SCAMMONIUM. (Lond. Dub.) See Convolvulus. SCILLA MARITIMA. Radix. (Ed.) ^ Scilla. Radix. (Lond. (Dub.) Squill. The root. Willd. g. 6\o.fp. 1. Hexandria Monogynia.—Nat. ord. Lilia- cea. The fquill is a perennial bulbous rooted plant, which grows wild on the fandy ffiores of Spain, Portugal, north of Africa, and the Levant. The root is about the fize of the fift, pear fhaped, with the apex upwards, and confifts ot fleffiy fcales, attenuated at both edges, furrounded by other fcales, which are arid, ffiining, and fo thin that the root at firft fight feems to be tunicated. The recent roots 304 Materia Medica. [Part II. are full of a white vifcid juice, have fcarcely any fmell, but a verv bitter, naufeous and extremely acrid tafte. Rubbed on the fkin it inflames and blifters. It is more commonly met with in the ffiops in the form of the dried fcales, which fliouid be brittle, femipellucid, fmooth, but marked with lines, and when chewed, ffiould feel tenacious, and tafte very bitter, without manifeft acrimony. The aaive conftituent of the fquill is the acrid principle ; and, therefore, it becomes almoft inert by two much drying, or by be- ing kept too long in the form of powder. It alfo contains bitter extraaive, much mucilage, albumen and ftarch. Given internally in large dofes, it produces purging and vomit- ing, fometimes even ftrangury, bloody urine, inflammation, and erofion of the ftomach. In fmaller dofes it proves a ufeful expec- torant and diuretic, and it is faid to lcffen the frequency of the pulfe. Squill is fometimes given as a general ftimulant in typhus^ efpecially to cattle. But it is much more frequently exhibited as an expeclorant where the lungs are loaded with vifcid matter, and as a diuretic in dropfical cafes, for which purpofe it is commonly conjoined with calomel. The dofe of fquill is one or two grains three or four times a day; and the moft commodious form for the taking of fquills, unlefs when defignedas an emetic, is that of a bolus, or pill ; li- quid forms are to moft people too offenfive, though thefe may be rendered lefs difagreeable both to the palate and ftomach by the addition bf aromatic diftilled waters. SCORDIUM. (Lond.) SeeTEUCRiUM. SENNA. (Lond. Dub.) See Cassia. SENEKA. (Lond. Dub.) See PolygalLa. SERPENT ARIA VIRGINIANA. (Lond. Dub.) See Aristolochia. SEVUM OV1LLUM. (Dub.) See Ovis. SIMAROUBA. (Lond. Dub.) See Qt ^SMA. SINAPIS. Willd.g. x2A6.Tetr adynamia Siliquofa.—'Cat. ord. Siliquofa. Sp. 4. Sin apis Alba. Semen. (Ed.j Sinapis. Semina- (Dub.) Wrhite muftard. Tbe feeds. Part II.] Materia Medica. 305 Sp. 5. Sinapis Nigra. Sinapis. Semen. (Lond.) Common muftard. The feeds. These plants are both annual, both grow wild in England, and poffefs fimilar virtues. They produce fmall round compreffed feeds, which have an acrid bitteriffi tafle, and a pungent fmell when reduced to powder. The common muftard has blackiffi feeds, and is more pungent than the white. Th^y impart their tafte and fmell in perfeaion to aqueous li- quors, whitft reaified fpirit extraas extremely little of either ; the whole of the pungency arifes with water in diftillation. Com- mitted to the prefs, they yield a confiderable quantity of a foft infipid oil, perfeaiy void of acrimony; the cake left after the ex- preffion, is more pungent than the muftard was at firft. Muftard feed is fwallowed entire, to the quantity of a table- fpoonful or more, to ftimulate the ftomach in fome cafes of dyf- pepfia, and to excite the periftaltic motion of theinteftines, efpec- ially when they are torpid, as in paralyfis. The powder made into a pafte with water, is commonly ufed as a condiment with animal food ; infufed in water, it proves emetic when taken in confiderable dofes, and in fmaller ones, aas as a diuretic and ape- rient ; but it is more frequently applied externally as a topical ftimulus, made into a pafte or finapifm with vinegar and bread- crumb. SIUM NODIFLORUM. Sium. Herba. (Lond.) Creeping fkerrit. The herb. Willd.g. 5\\.fp. 4. Pentandria Digynia.—Nat. ord. Umbel- lata. This plant is perennial, and grows wild in rivers and "ditches in England. It was formerly alleged to be not only a diuretic, but alfo an emmenagogue and lithontriptic. With thefe inten- tions, however, it is not now employed. Dr. Withering mentions that a young lady of fix years old was cured of an obftinatecuta- necus difeafe by taking three large fpoonfuls of the juice twice a^ day ; and he adds ; that he has given repeatedly to adults three- or four ounces every morning, in fimilar complaints. In fuch dofes it neither affects the head, ftomach, nOr bow,els. Children take it readily when mixed with milk. SISYMBRIUM NASTURTIUM. Herba. (Ed.) Nafiurtium aquaticum. Herba resens. (Lond.) Herba. (Dub.) Common water creffes. The recent herb. Willd. g. it$. fp. 1. Tetradynamia Siliquofa.—Nat. ord. Si- ll tuof a. W 306 Materia Medica. [Part II. This plant is perennial, and grows wild in clear fprings and rivulets throughout Britain. Its leaves remain green all the year, but are in greateft perteaion in the fpring. They have a quick pungent fmell (when rubbed betwixt the fingers) and an acrid tafte, fimilar to that of fcurvy grafs, but weaker. By dryiag or boiling it lofes its fenfible qualities entirely. It aas as a gentle ftimulant and diuretic ; for thefe purpofes, the expreffed juice, which cootains the peculiar tafte and pungen- cy of the herb, may be taken in dofes of an ounce or two, and continued for a confiderable time. SMILAX SARSAPARILLA. Radix. (Ed.) Sarfaparilla. Radix. (Lond. Dub.) Sarfaparilla. The root. Dioscia Hexandria.—Nat. ord. Sarmentacea. This root is brought from the Spaniffi Weft Indies. It con- fifts ofa great number of long firings hanging from one head; the long roots, the only part made ufe of, are about the thicknefs of a goofe quill, or thicker, flexible, compofed of fibres running their whole length, fo that they may be ftript into pieces from one end to the other. They have a glutinous, bitteriffi, not un- grateful tafte, and no fmell. It was firft brought into Europe by the Spaniards, about the year 1563, with the charaaer of a fpe- cific for the cure of the lues veuera, a difeafe which made its ap- pearance a little before that time, and likewife of feveral obfti- nate chronic diforders. It is, however a yery inert mucilaginous fubftance ; and the diaphorefis, which it is fometimes fuppofed to produce, is entire- ly owing to the warm and diluent regimen employed at the fame time. SOLANUM DULCAMARA. Dulcamara. Stipites. (Dub.) Bitter fweet. The twigs. Willd.g. 383.^. 15. Pentandria Monogynia.—-Nat. ord. So- lanacece. This plant grdws wild in moift hedges, and climbs on thebufh- es with woody brittle ftalks. The tafte of the twigs and roots, as the name of the plant expreffes, is both bitter and fweet; the bit- ternefs being firft perceived, and the fweetnefs afterwards. The dulcamara was formerly much efteemed as a powerful medicine. It is in general faid to occafion fome confiderable evacuation by -fweat. urine, or ftool, particularly the latter. It has been recom- mended as a difcutient and refolvent medicine ; and it has been faid to be attended with good effeas in obftinate cutaneous dif- eafes of the herpetic kind. It has alfo been ufed, and fometimes with advantage, in cafes of rheumatifm, jaundice, and obftruaed Part II.] Materia Medica. $oi menftruation. It has principally been Employed under the form Of watery infufion, fometimes under that of extraa. SOL1DAGO VIRGA AUREA. Virga aurea. Flores. Folia. (Dub.) Golden rod. The flowers and leaves. Syngenefia Superflua.—Nat. ord. Compofita radiata. This plant is perennial, and is found wild on heaths and in woods, producing fpikcs of yellow flowers in Auguft. The leaves have a moderately aftringent bitter tafte ; and hence prove fer- viceable in debility and laxity ot the vifcera, and diforders pro- ceeding from that caufe. SPARTIUM SCOPAR1UM. Summitates. (Ed.) Genifla. Semina. (Dub.) Cacumen. Semen. (Lond.) Common broom. The tops and feeds. Diadelphia Decandria.—Nat. ord. Papilionacea. This is a very common ffirub on dry paftures. The leaves have a very bitter tafte, and when given in decoc« tions prove confiderably diuretic. The feeds have fimilar prop- erties, SPERMACETI. (Lond. Dub.) SeePiiYSETER. SPIGELIA MARILANDICA. Radix. (Ed.) Spigelia. Radix. (Lond. Dub.) Carolina pink. The root. Willd. g. 308. fp. 2. Pentandria Monogynia.—Nat. ord. Stel- lata. This plant is perennial, and grows wild in the fouthern parts of North America. The roots are celebrated as an anthelmintic particularly for the expulfion of lumbrici from the alimentarv canal. Some order it in dofes ot ten or fifteen grains ; tnd allege it is apt to occafion nervous affeaions if given in large dofes * while others order it in drachm dofes, alleging that the badeffeas mentioned more readily happen from fmall dofes, as the large ones often purge or puke; fome prefer the form of infufion. An emetic is generally premifed ; and its purgative effea affifted by fome fuitable additions. SPINA CERVINA. (Lond.) SeeRHAMNUS. SPIRITUS VINE (Lond. Dub) See Alcohol. SPONGIA OFFICINALIS. (Ed.) Spongia. (Lond. Dub.) Sponge. pr 2 ^C3 Materia Medica. [Part II. Cl. Zoophyta. Ord. Spongia. * Stonge is principally"found in the Mediterranean and Red Seas. It was long fuppofed to be a vegetable produaion, but it is n»w univerfaliy allowed to belong to that remarkable clafs of animals c 'led Zoophytes, which are negatively charaaerized by Cuvier, as having no vertebrae, no fanguiferous veffels, no fpinal marrow, and no articulated limbs. The fponges belong to that divifion of the zoophytes, which are attached to a folid trunk, and are particularized by their bafe being fpongy, friable or fi- brous. Sponge is a foft, light, very porous and compreffible fubftance. From its property of imbibing and diftending by moifture, it is fometimes made ufe of as a tent for dilating wounds and ulcers. To fit it for thefe intentions, the fponge is immerfed in melted wax, and fubjeaed to preffure till cool ;' in this ftate it may be eafily formed into proper tents, foas to be introduced where nec- effary. And from the gradual melting of the wax in confequence of the heat of the part, a dilatation of courfe takes place. It adheres ftrongly to the mouths of wounded veffels; and when retained by proper compreffion, it is preferable to agaric or puff ball for flopping haemowhagies. Burnt fponge is nothing elfe than charcoal mixed with a little muriate of foda and phofphate of lime. STALAGMITIS CAMBOGIOIDES. Gambogia. Gummi refina. (Ed. Lond. Dub.) The gum refin called Gamboge. Polygamia Monacia.—Nat. ord. Tricocca. The tree which furnifhes the gamboge is of middling fize, and grows wild in the kingdom of Siam and in Ceylop. In Siam the gum refin is obtained in drops by breaking the leaves and young flioots, hence probably its name Gummi guttae ; but in Ceylon the juice is obtained in confiderable quantities by wounding the bark, and is afterwards dried in the fun. It is brought from the Eaft Indies in large cakes or rolls. The\ beft fort is ofa deep yellow or orange color, breaks ffiining, ang free from impurities. It has no fmell, and very little tafte, unlefs kept in the mouth for fome time, when it impreffes a flight fenfe of acrimony. It it almoft entirely foluble in alcohol, and in fpirit of ammonia, form- ing tranfparent folutions of a bright golden color ; and the re- fiduum is totally foluble in water. The alcoholic folution is de- compofed by water, becoming yellow and opaque ; but the fub- ftance feparated remains long fufpended, and cannot be feparated by common filtering paper. The folution in vinous fpirit of am- monia is not decompofed by water, but the addition of any acid immediately produces a copious yellow precipitate, which differs from refin in being infufible and difficultly combuftible, and i« Part H-] Materia Medica. 30r> having an earthy fraaure when dried. The refiduum, foluble in WffCr feems to be pure gum. Gamboge itfelf is almoft totally diffufible in water, forming a turbid yellow liquor. Gamboge evacuates powerfully both upwards and downwards; fome condemn it as aaing with too great violence, and occafion- ing dangerous hypercatharfis ; while others are of a contrary opin- ion. Geoffroy feems particularly fond of this medicine, and in- forms us, that he has frequently given from two to four grains, without its proving at all emetic ; that from four to eight grains both vomit and purge without violence ; that its operation is foon over; and that if given in a liquid form, and fufficiently diluted, it does not need any correaor; that in the form of a bolus or pill, it is moft apt to prove emetic, out very rarely has this effea if joined along with Calomel. He neverthelefs cautions againft its ufe where the patients cannot eafily bear vomiting. It has been ufed in dropfy with cream of tartar or jalap, or both, to quicken their operation. It is alfo recommended by fome to the extent of fifteen grains, with an equal quantity of vegetable al- kali, in cafes of the tape worm. This dofe is ordered in the morning; and if the worm is not expelled in two or three hours, it is repeated even to the third time with fafety and efficacy. It is afferted, that it has been given to this extent even in delicate habits. It is an ingredient, and probably the aaive one, in moft of the noftrums for expelling tzeniae. STANNUM. (Lond.) Limatura et pulvis. (Dub. Ed.) The general properties of tin have been already mentioned (1630 It is found, 1. Sulphuretted, and combined with copper. Tinpyrites. a. Oxidized. a. Combined with oxide of iron and filica. Common tin ftone. b. Combined with oxide of iron and a little arfenic. Fibrous tin ftone. , The beft tin is found in Cornwall, or is brought from the Eaft Indies. Its pUrity is eftimated by its fmall fpecific gravity, and by the crackling noife it makes when bent. It is now only ufed as an anthelmintic, efpecially in cafes of tae- nia, and probably afcts mechanically. STAPHISAGRIA. (Lond. Dub.) See Delphinium. STIBIUM. (Dub.) See Antimonium. 310 ' Materia Medica. Part. II.] STYRAX. JFilld. g. 874. Decandria Jflonogynia.—Nat. ord. Bicornes. Sp. 1. Styrax Officinale. Balfamum. (Ed.) Styrax. Refina. (Lond.) Styrax calamita. Refina. (Dub.) Storax. A balfam. This tree grows in the Levant, and in Italy and France. The ftorax flows from wounds made in the bark, in countries where the heat is fufficient, for neither in France nor in Italy does it fur- nifh any. It is either in fmall diftina tears, of a whitiffi or reddifh color, or in large maffes compofed of fuch, or in maffes of an uniform texture and yellowiffi red or browniffi color; though fometimes likewife interfperfed with a few whitiffi grains. The common fiorax of the ffiops is in large maffes, confiderably lighter and lefs compaa than the foregoing ; it appears on exami- nation to be compofed of a fine refinous juice, mixed with a quan- tity of faw dull. - — Storax has an agreeable fmell, and an aromatic tafte/ It is fo- luble in alcohol, and only imparts a little of its flavor to water. In diftillation it yields benzoic acid. "It is, therefore, a balfam, or natural combination of refin with benzoic acid. Sp. 3. Styrax Benzoin. Balfamum. (Ed.) Benzo'e. Refina. (Lond.)- Benzoinum. Refina. (Dub.) Benzoin, a balfam. This fpecies grows in Sumatra, and, like the former, alfo fur- nifhes a balfam on being wounded. It is brought from the Eaft Indies only ; in large maffes com- pofed of white and light brown pieces, or yellowiffi fpecks, break- ing very eafily betwixt the hands ; fuch as is whiteft, and free from impurities, is moft efteemed. f In its properties it differs from ftorax, only in containing a' larg- er proportion of benzoic acid. ■ SUB ACETIS CUPRI. (Ed.) See Cuprum. SUB BORAS SODJE. Boras Soda. (Ed.) Borax. (Lond. Dub.) Sub borate of foda. Borax. - • Borax is found only in Thibet and Perfia. It exifts in the water of fome wells and lakes, and is extraaed from them by evap- oration. In its impure ftate it is called tincal, and is brought from the Eaft Indies in great maffes, compofed of a few large cryftals, but chiefly of fmaller ones, partly white and partly green, joined together as it were by a greafy yellow fubftance, intermixed with fand, fmall ftones, and other impurities. By repeated folutions, filtration^, and cryftallizations, it ffioots into hexangular prifms, il. . .. 1 Part II.] - Materia Medica. 311 of which two fides are broader than the others, terminated by triangular pyramids, of a "white color, a ftyptic and alkaline tafte, coloring vegetable blues green, foluble in eighteen parts of water at 6o°, and in fix at 212°, flightly efflorefcing in the air, and when heated, fwelling, and, with the lofs of nearly half its weight, forming a porous friable mafs, which, in a greater heat, melts in- to a tranfparent glafs foluble in water. Befides the acids and al- kalies which have a greater affinity for its acid or bafe than thefe have for each other, it is decompofed by fulphates, muriates, ni- trates, phofphates, and fluates ot all the earths and of ammonia. It confifts of 39 boracic acid, 17 foda, and 44 water. The medical virtues of borax have not been fufficiently afcer-* tained by experience; it is fuppofed to be in dofes of halt a drachm or two fcruples, diuretic, emmenagogue, and a promoter of delivery. Mr. Biffet, in an effay on the medical conftitution of Great Britain, recommends a folution of this fait in water, as the moft powerful diffolvent yet known, of aphthous crufts in the mouth and fauces of children. And tor the fame purpofe alfo, a fmall quantity of it is often applied in "the form of powder mixed up with fugar. There are ftrong reafons to believe, that the vir- tues of borax are much greater than they are in general fuppofed to be ; and that it may be more extenfively ufed with .advantage. SUCCINUM. (Ed. Lond. Dub.) Amber. This is„ a folid, brittle, bituminous fubftance, dug out of the earth, or found upon the fea ffiores ; the largeft quantities are met with along the coafts of Poliffi Pruflia and Pomerania. It is ofa white yellow, or brown color, fometimes opaque, and fometimes very clear and tranfparent. It emits an agreeable fmell when heated or rubbed. By fric- tion it becomes elearic; and when heated it foftens, fwells, and then melts and burns with a greeniffi or bluifh flame, leaving a coaly refiduum. By diftillation it affords a little acetous acid, an . effential oil; and apeculiar acid, named from it the Succinic (303.) It is not acled upon by water, alkalies, or diluted acids. It is imperfeaiy diffolved in alcohol and ether ; and perfeaiy in the expreffed oils, and in boiling nitrous acid. In the laft cafe, how- ever, it is previoufly oxygenized and altered confiderably in its "nature. It is only kept for the effential oil and acid obtained from it. • SULPHAS. Sulphate is a generic term for the combination of fulphuric acid with the alkalies, earths, and metallic oxides. Their gene- ric charaaers have been already noticed (190.) Like the other genera, they may be divided into three families. G^4 512 Materia Medica. Part II.] Family 1. Alkaline fulphates.—Thefe form no precipitate with alkaline carbonates. Family 2. Earthy fulphates.—Thefe are either infoluble in wa- ter, or, it foluble, form a white precipitate with alkaline carbo- nates, Family 3. Metalline fulphates.—Thefe form precipitates, which are often colored, with alkaline carbonates in general, with prufli- ate of potafs and iron, and with gallic acid. SUPER SULPHAS ALUMINA ET POTASSjE. Sulphas Alumina. (Ed.) Alumen. (Lond. Dub.) Super fulphate of alumina and potafs. Alum. Alum is obtained principally from fchiftofe clays, which con- tain iron pyrites, by roafting, expofure, lixiviation, the addition "ofa proportion of potafs ley, and cryftallization. The roafting deftroys the bituminous matters thefe clays com- monly contain, the expofure to the air acidifies the fulphur of the pyrites, and the addition of alkali is abfolutely neceffary for the conftitution of alum, which is a triple fait, with excefs of acid, confiftingof fulphuric acid, alumina, and'potafs, or ammonia, or a mixture of both. The properties of alum do not feem to be af. feaed by the nature of the alkali. Alum cryftallizes in regular oaohedrons, whofe fides are equi- latural triangles. It has a fweetifh but very aftringent tafte. It is foluble in 15 times its weight of water at 6o», and in three fourths of its weight at U2». It reddens vegetable blues. It ef- florefces flightly in the air- By the aaion of heat it firft under- goes the watery fufion, then lofes its water of cryftallization, and laftly great part of its acid. It is decompofed by baryta, potafs, ■ foda, ftrontia, and all falts of which thefe are the bafes ; by the nitrate, muriate, phofphate, carbonate, borate, and fluate ot am- monia ; by the nitrate, muriate, phofphate, and carbonate of mag- nefia ; and vby the nitrate, muriate, and carbonate of lime. It is alfb decompofed by the gallic acid, by coloring matters, and by many animal and vegetable fubftances, in a manner not yet fuffi- • ently underftood. It commonly confifts, according to Vauquelin, of 49 fulphate of alumina, 7 fulphate ot potafs, and 44 of water. Alum is a powerful aftringent ; it is reckoned particularly fer«# viceable for reftraining hzemorrhagies, and immoderate fecretions from the blood ; but lefs proper in inteftinal fluxes. In violent nacmorrhagies, it may be given in dofes ot fifteen or twenty grains, and repeated every hour or half hour till the bleeding abates ; in other cafes, fmaller dofes are more advifable; large ones being apt to naufeate the ftomach, and occafion violent conftipations of the bowels. It is ufed alfo externally, in aftringent and repel- lent lotions and collyria. Burnt alum taken internally has been Part II.] Materia Medica. . 513 highly extolled in cafes of colic. In fuch inflances, when taken to the extent of a fcruple for a dofe, it has been faid gently to move the belly, and give very great relief from the fevere pain. SULPHAS BARYTA. Sulphate of baryta. Ponderous fpar. This fait has bees omitted in the lift of the materia medica of the Edinburgh College ; for they afterwards employ it ior the preparation of the muriate of baryta. It is found in great abundance in many countries, either in a loofe earthy form, or compaa, ©r foliated, or flriated, or acicular. The foliated is in general the pureft. Its fpecific gravity is from 4.4104.86,5. It is infoluble in water. It is foluble in boiling concentrated fulphuric acid. It decrepitates when fuddenly heat- ed. By being formed into a thin cake with flour and water, and being afterwards heated to rednefs, it becomes phofphorefcent. Heated to rednefs with charcoal, it is converted into a fuiphuret, and it may be decompofed either by boiling, or in a crucible, with the carbonates of potafs and of foda. It contains about 84 ot baryta, and 16 fulphuric acid and water. SULPHAS CUPRI. (Ed.) See Cuprum. SULPHAS MAGNESIA. (Ed.) Mqgnefia Vitriolata. (Lond. Dub.) Sulphate of magnefia. Epfom fait. This fait is contained in feveral mineral fprings, and alfo in fea water, from which it is obtained by evaporation. It cryftal- lizes in tetrahedral prifms. It has a very bitter tafte. It is folu- ble in its own weight of water at 6o°,'and three fourths of is weight of boiling water. It cfflorefces in the air, and falls to powder. By the aaion of heat it undergoes the watery fufion, and lofes its water of cryftallization, but does not part with its acid. It is decompofed by baryta, ftrontia, the alkalies, and all the falts formed by thefe falifiable bafes, excepting the alkaline muriates ; and by the nitrate, muriate, and carbonate of lime. It is a mild and gentle purgative, operating with fufficient effi- cacy, and in general with eafe and fafety, rarely occafioning any gripes, ficknefs, or the other inconveniences which purgatives of 4he rofinou* kind are too often accompanied with. Six or eight drachms may be diffolved for a dofe in a proper quantity of com- mon water ; or four, five, or more, in a pint, or quart of the purging mineral waters. Thefe liquors may likewife be fo man- aged as to promote evacuation by the other emunaories ; if the patient be kept warm, they increafe perfpiration ; and by mod- erate exercife in the cool air, the urinary difcharge. Some allege this fait has a peculiar effea in allaying pain, as in colic, even in- dependently of evacuation. 314 Materia Medica. [Part II. Is is principally ufed for the preparation of "the carbonate of macrnefia. O SULPHUR SUBLIMATUM. (Lond. Dub. Ed.) Sublimed fulphur. We have already (136.) mentioned the properties ot fulphur. In the neighborhood of volcanoes it is fometimes found per- fectly pure and cryftallized ; but all the fulphur of commerce is extraaed from pyrites by fublimation. It is ufually brought to us in- i.irgt^ irregular maffes, which are afterwards melted and caft into cylindrical roils, with theaddition of fome coarfe refin, flour or the like ; whence the paler color of the rolls. Sulphur ffiould be chofen of a bright yellow color, ffiould be very inflammable, and fhould burn with a bright pure blue flame. Sublimed fulphur is never prepared by the apothecary. It has the form of a very fine powder, having a beautiful yellow color. It often is contaminated with a little fulphuric acid, formed dur- ing the procefs, from which it is eafily freed by waffiing. Pure fulphur loofens the belly, and promotes infenfible perfpi- ration ; it feems to pafs through the whole habit, and manifeftly tranfpires through the pores of the fkin, as appears from the ful- phureous fmell of perfons who have taken it, and from fllver being f lined in their pockets of a blackiffi color, which is the known effect of lulphureous fumes. It is a celebrated remedy againft cu- taneous difeafes, both given internally, and externally applied. It has likewife been recommended in coughs, afthmas, and other dif- orders of the breaft and lungs; and particularly in catarrhs of the chronic kind. But it is probable, that the benefit derived from it in thefe cafes is principally, if not entirely, to be attributed to its operation as a gentle laxative. And with this intention it is frequently ufed with great advantage in hsemorrhoidal affeaions, and many other difeafes in which it is proper to keep the belly gently open. SULPHURETUM ANTIMONII. (Ed.) SccAntimo- NIU M. SULPHURETUM HYDRARGYRI RUBRUM. (Ed.) See Hydrargyrum. SUPER TARTRTS POTASS^!. (Ed.) 'lartari Cryjlalli. (Lond.) Tartarum, cryflalli et cremen dic- tum. (Dub.) Super tartrite of potafs, cryftals of tartar, and cream of tartar. Super Tartris Potass^ impurus. (Ed.) Tartarum. (Lend.) Part II.] Materia Medica. 315 Impure fuper tartrite of potafs. Tart;;r. Tartar exifts in verjuice and in muft, and is depofited on the fides of the cafks by repofe, from which it is fcraped fome time before the next vintage, to prepare the cafks to receive the new wine. The deepeft colored and coarfeft wines generally give moft tartar, and it gets the name of white or red tartar according to its color. It is purified by diffolving it in boiling water, and feparating the earthy part by filtrating the boiling folution. On cooling the folution, it depofites irregular cryftals, containing the oily and co- loring matters, which are feparated by boiling the mals with a white clay. The tartar thus purified, when cryftallized, or in powder, is called Cream of Tartar. Its cryftals are fmall and irregular, and do not melt in the mouth, but feel gritty under the teeth. It has an acid harffi tafte. It is foluble in fixty times its weight of water at 60°, and in thir- ty at 212°. It is decompofed, and its acid is deftroyed, by heat. It contains 23 parts of potafs, according to Bergman, and 33, ac- cording to Thenard. The virtues of tartar are thofe ofa mild, cooling, aperient, lax- ative medicine. It is much ufed in dropfy ; and fome allege that it has good effeas as a deobftruent, in dropfy from fcirrhus. Tak- en from half an ounce to an ounce, it proves a gentle, though effec- tual purgative. Given in fmaller dofes, and in folution, it often acls as a powerful diuretic. SUS SCROFA. Adeps. (Ed.) Sus. Adeps. (Lond.) Adeps fuillus. (Dub.) The hog. The fat. Hogs lard. CI. Mammalia.—Ord. Pachyderma. In hogslard we have a very pure animal fat, almoft entirely free from any peculiar impregnation, and of a foft confiftence. Hence it is a very ufeful emollient for relaxing thofe pans to which it is applied; and it is alfo a ver/convenient article tor giving the proper confiftence to ointments, platters, and liniments. Indeed this and the fevum ovillum, or mutton fuet, are the only fats now retained by theLondonand Edinburgh Colleges,although formerly more than twenty different fats entered fome lifts ot ma- teria medica. Each particular tat was then fuppofed to poffefs peculiar properties ; but for this there is probably no foundation; even thofe retained are now lefs employed than before, as it has been imagined that a proper confiftence of any kind may be more certainly obtained by determined proportions of wax and oil; but as thefe articles are more expenfive, hogslard and mutton Pact are «f ten fubflituted for them by the apothecaries. 216 Materia Medica. [Part. II. SWIETEN1A. Willd. £.843. Decandria Monogynia.—Nat. ord. Trihilatct. Sp.i. Swietenia Mahagoni. Cortex. (Ed.) Mahogany tree. The bark. This majefiic tree grows principally in Jamaica and in Spanifh America. Its ufeful wood is univerfaliy known. Its bark i> brown, rough, and fcaly ; on the branches grey and fmoother. its tafte is very aftringent, and bitterer than that of Peruvian bark. Its fmell weak and aromatic. In its properties and aaion on the living body, it coincides with Peruvian bark, and may be fubfii- tuted for it in many fituations. Sp. 2. Swietenia Febrifuga. Cortex. (Ed.) Febrifuge Swietenia. The bark. This fpecies, which in many refpeas refembles the former, is a native of the Eaft Indies. Its bark is red, brittle, and compact, and covered with a rough grey cuticle. In its properties it agrees with the Mahogany bark, and forms a very valuable fubftitute for Peruvian bark in the Eaft Indies, where this laft is fo dear and fcarce, and the difeafes in which it is indicated fo common. Dr. Roxburg fent from India a quantity of the extraa of this bark, which could not be diftinguifhed from the kino of the ffiops. TAMAR1NDUS IND1CA. Fruclus conditus. (Ed.) Tamarindus. Fruclus. (Lond. Dub.) Tamarind tree. The preferved fruit. Willd. g. 1250. fp. x. Monadelpkia Triandria.—Nat. ord. Lomentacea. This tree grows both in the Eaft and Weft Indies. The fruit is a broadafficolored pod. The external covering is thin and brit- tle, and contains feveral hard feeds, enveloped in a foft brown pulp. Tamarinds are cured in two ways. The common way is to throw hot fugar from the boilers on the ripe pulp ; but a better method is to put alternate layers of tamarinds and powdered fugar in a ftone jar. By this means the tamarinds preferve their color and tafte more agreeably. Eaft India tamarinds are longer than the Weft India fort; the former containing fix or feven feeds each, the-latter rarely above three or four. Preferved tamarinds ffiould be freffi and juicy, and ffiould have an agreeable acid tafte. They ffiould not have a mufty fmell; the feeds ffiould not be foft and fwollen, and the blade of a knife ffiould not get a coating of copper by being immerfed amongft them. Tamarinds contain fugar, mucilage, citric acid, fuper tartrite of potafs, tartarous acid, and malic acid. Part II.] Materia Medica. 317 The pulp of thefe fruits, taken in the quantity of from two or three drachms to an ounce or more, proves gently laxative and purgative, and at the fame time, by its acidity, quenches thirft, and allays immoderate heat. It increafes the aaion of the pur- gative fweets, caffia and manna, and weakens that of the refinous cathartics. Salts, whofe bafe is potafs, form an improper addition to tama- rind, for they are decompofed, and the tartarows acid or the fruit is precipitated in the forrri*of fuper tartrite of potafs. TANACETUM VULGARE. Folia, Flores. (Ed.) Tana»etum. Folia. (Dub.) Flos, Herba. (Lond.) I anfy. The flowers and leaves. Syngenefia fuperflua.—Nat. ord. Compofita difceide^e. Tansy is perennial, and grows wild by road fides and the bor- ders of fields, and is frequently alfo cultivated in gardens, both for culinary and medicinal ufes ; it flowers in June and July. Confidered as a medicine, it is a moderately warm bitter^ accom- panied with a ftrong, not very difagreeable flavor. Somephyfi- cians have had a great opinion of it in hyfteric diforders, partic- ularly thofe proceeding from a deficiency or fuppreffion of the u- terine purgations. The leaves and feeds have been of confidera- ble efteem as anthelmintics ; the feeds are lefs bitter, and more acrid and aromatic than thofe of rue, to which they are reckoned fimilar ; or of fantonicum, tor which they have been frequently fubftituted. An infufion of tanfy, drunk in a manner fimilar to tea, has been ftrongly recommended as a preventive ot the return ofgout. TARAXACUM. (Dub.) See Leontodon. TARTARUM. (Dub.) See Super Tartris Potass*:. TEUCRIUM. Willd. g. 1093. Didynamia Gymnofpermia.—Nat. ord. Vetti- cillata. 'Sp. 12. Teucrium Marum. Marum Syriacum. Herba. (Lond. Dub.) Syrian herb maftich. This is a fmall ffirubby plant, growing fpontaneoufly in Syria, Candy, and other warm climates, and cultivated with us in gar- dens. The leaves have an aromatic, bitteriffi tafte; and, when rubbed betwixt the fingers, a quick pungent fmell, like volatile alkali, which foon effeas the head, and occafions fneezing; diftil- led with water, they yield a very acrid, penetrating effential oil, refembling that of fcurvy grafs. Thefe qualities fufficiently point 313 Materia Medica. [Part II. out the ufes to which this plant might be applied ; at prefent it is little otherwife employed than in cephaltic fnuffs. 5/7.34. Teucrium Scordium. Scordium. Herba. (Lond.) Water germander. The herb. This is a fmall, fomewhat hairy, perennial plant,growing wild in fome parts ot England, though not veiy common ; the ffiops are generally fupplied from gardens. It has a bitter tafle, and a ftrong difagreeable fmell. TEREBINTHINA. (Lond. Dub.) THUS. (Lond.) See Pinus. TOLUIFERA BALSAMUM. Balfamum. (Ed.) Balfamum Tolutanum. (Lond. Dub.) Balfam of Tolu. Willd.g. 828. fp. 1. Decandria Monogynia.—Nat. ord. Lomen- tacea- This tree grows in Spaniffi America, and the Balfam flows from incifions made in its bark, during the hot feafon, and is brought to us in little gourd ffiells. It is of a yellowiffi brown color, inclining to red ; in confiftence thick and tenacious; by age it grows hard and brittle, without fuffering any great lofs of its more valuable parts. The fmell of this balfam is extremely fragrant, fomewhat refembling that of lemons ; its tafte warm and fweetiffi. In its medicinal virtues it agrees with the other balfams. TORMENTILLA ERECTA. Radix. (Ed.) Tormentilla. Radix. (Lond. Dub.) Septfoil. The root. Willd.g. 1001. fp. 1. Icofandria Polygyria,—Nat. ord. Sen- tic ofa. Tormentil is perennial, and found wild in woods and on commons ; it has long flender ftalks, with ufually feven long nar- row leaves at a joint ; the root is for the moft part crooked ar;d knotty, ofa blackiffi color on the outfide, and a reddiffi within. This root has an aufter'e ftyptic tafte, accompanied with a flight kind of aromatic flavor; it is one of the moft agreeable and efficacious of the vegetable aftringents, and is employed withgood effea in all cafes where medicines of this clafs are proper. TRAGACANTHA. (Lond.) See Astragalus. TRIFOLIUM PALUDOSUM. (Lond. Dub.) SeeMzNY- ANTHES TRIFOLIATA. Part II.] > Materia Medica. 319 TR1GONELLA FOENUM GR.ECUM. Foenum Gracum. Semen. (Lond.) Fenugreek the feeds. Diadetphia Decandria.—Nat. ord. Papilionacea. 1 His plant is annual, and a native of the fouth ot France. In Poland it is cultivated in large quantities. The feeds have a yellowiffi color, a rhomboidal figure, a difagreeable iirong fmell, and a mucilaginous tafte. Their principal ufe .was in caicqjlaltns, fomentations, and the like, and in emollient glyfters. TRITICUM. Willd.g. 1^2. Triandria Monogynia.—Nat. ord. Gramina. Sp. i. Triticum yEsTivu.M. Seminum Farina. Amylum. (Dub.) * Sp. 2. Triticum Hybernum. Farina. Amylum. (Lond.) Wheat. Flour. Starch. By fome thefe are confidered only as varieties, and as diftina fpecies. The latter, however, is the moft produaive, and is moft commonly cultivated on that account; for there is no material dif- ference between the grains they produce, which are indifcrimin- ately employed for every purpofe. I' Wheat flour confifts principally of gluten, ftarch, albumen, and a fweet mucilage. Thefe may be feparated by forming the flour into a palte with a little water, and waffiing this pafte with freffi quantities of water, until it runs from it colorlefs. What remains is the gluten ; which, if not the fame, is very analogous to the fibrine of animal fubtlances (272.) From the water with which the pafte was wafhed, a white powder feparates on land- ing. This is the ftarch (855.) which we have already mentioned under the title Amylum. The albumen and fweet mucilage remain diffolved in the water. By evaporating it, the albumen firft feparates in white flakes, and the fweet mucilage may begot by total evaporation. It is the prefence of gluten which charaaerizes wheat florr ; and on the due admixture ot it with the other conftituents, de- pends the fuperiority of wheat flour for baking bread. Bread is made by working the flour into a pafte with water, a quantity of fome ferment, fuch as yeaft, and a little muriate of foda to render it fapid, allowing the pafte to ftand until a certain degree of fermentation take place, and then baking it in an oven heated to about 48&0. During the fermentation a quantity of gas is formed, and as it is prevented from efcaping by the tough- nefs of the pafte, and dilated by the heat of the oven, the bread is rendered light and fpongy. In this procefs the nature of the con- ftituents of the flour is altered, for we are not able to obtain cither gluten or ftarch from bread. t S20 Materia Medica. [Part II. Bread is not only one of the moft important articles of nourifh- ment, but is alfo employed in pharmacy for making cataplafms, and giving form to more aaive articles. An infufion of toafted bread has a deep color, and pleafant tafte, and is an excellent drink in febrile difeafes, and debility of the ftowiach. The change which bread undergoes by toafting is not known ;' but it is prob. ably very fimilar to that produced in coffee by the fame means. In raw coffee there is no tannin ; in roafted coffee it is abundant. TUSSILAGO FARFARA. Folia. Flores. (Ed.) Tuffilago. Herba. (Lond.) Folia. (Dub.) Colt's foot. The herb and flowers. I Syngenefia fuperflua.—Nat. ord. Compofita radiate. This grows wild in moift fituations, producing yellow flowers in February and March ; thefe foon fall off, and are fucceeded by large roundift'leaves, hairy underneath ; their tafte is herbaceous fomewhat glutinous and fubacrid. Tuffilago is recommended in coughs, phthifis, and other difarders of the breaft and lungs, and fome ufe it in fcorfula. It is chiefly direaed to be taken with milk ; and upon this probably, more thao on the tuffilago itfelf, any benefit derived from it in praaice is to be explained. ULMUS CAMPESTRIS. Cortex, interior. (Ed.) Ulmus Cortex interior. (Lond. Dub.) Elm tree. The inner bark. Willd. g. 505. fp. 1. Pentandria Digynia—Nat. ord. Sea- brida. This tree grows wild in Britain. The inner bark has a yel- lowiffi color, and a mucilaginous, bitter, aftringent tafte, without fmell. A decoaion formed from it, by boilingan ounce with a pound of water, to the confumption of one half, has been highly recom- mended in the lepra ichthyofis, and has been faid to cure dropfies. .URTICA DIOICA. Urtiea. Herba. (Lond.) Common nettle. The plant. Monoecia Tetrandria.—Nat. ord. Scabrida- This is a well known perennial weed. The leaves of the frefh plant ftimulate, inflame, and raife blifters on thofe parts o£,:tV* fkin which they touch. Hence, when a powerful rubefaefc^t is v required, flinging with nettles has been recommended£/-Itias been alleged to have fometimes fucceeded in reftoring fe^fownd motion to paralytic limbs. UVA URSI. (lond. Dub.) SeeARBUTWs. Part II.] Materia Medica. 321 UV^E PASS^E. (Lond. Dub.) See Vitis. VALERIANA OFFICINALIS. Radix. (Ed.) Valerianafylvefiris. Radix. (Lond. Dub.) Wild velerian. The root. Willd. g. 75. fp. 6. Triandria Monogynia.Nat. ord.—Aggregata. This plant is perennial, and grows wild in Britain. Like ma- ny other plants, it varies in its appearance and fenfible qualities, according to the fituation in which it grows. In marfhes and fhadowy places its leaves are broa"Her, on dry heaths and high paf- tures they are narrower. The roots produced in low watery grounds, have a remarkably faint fmell in comparifon of the others, and fometimes fcarce any at all. The roots taken up in autumn or winter, have alfo much ftronger fenfible qualities than thofe colleaed in fpring and fum- mer. The root confifts of a number of firings or fibres matted toge- ther, iffuing from one common head ; of a whitifh or pale brown- iffi color; its fmell is ftrong, like a mixture of aromatics with fetids ; the tafle unpleafantly warm, bitteriffi, and fubacrid. Wild valerian is a medicine of great ufe in nervous diforders, and is particularly ferviceable in epilepfies, proceeding from a de- bility of the nervous fyftem. Some recommend it as ufeful in procuring fleep, particularly in fever, even when opium fails : But it is principally ufeful in af- feaions of the hyfterical kind. The common dofe is from a fcruple to a drachm in powder j and in infufion, from one to two drachms. Its unpleafant flavor is moft effeaually concealed by a fuitable addition of mace. As its virtues refide entirely in an effential oil, the decoaion and extraa are improper forms for exhibiting it. VERATRUM ALBUM. Radix. (Ed.) Helleborus albus. Radix. (Lond. Dub.) White hellebore. The root. Polygamia Monoecia.—Nat. ord. Liliaceot. This plant grows fpontaneoufly in Switzerland and the moun- tainous parts of Germany. The root has a naufeous, bitteriffi, acrid tafte, burning the mouth and fauces; if wounded when treffi, it emits an extremely acrimonious juice, which mixed with the blood, by a wound, is faid to prov e very dangerous ; the pow- der of the dried root, applied to an iffue, occafions violent purg- ing; fnuffed up the nofe, it proves a ftrong, and not always a fafe fternutatory. This root, taken internally, aas with extreme vio- lence as an emetic; and has been obferved, even in a fmall dofe, to •c:afion convulfions, and other terrible diforders. The ancients 322 Materia Medica. [Part II. fometimes employed it in very obftinate cafes, and always made this their laft refource. Modern praaice feems to have almoft entirely rejeaed its internal ufe, though fome have ventured up- on fo large a dofe as a fcruple, in maniacal cafes, and are faid to have experienced good effeas from it. VERONICA BECCABUNGA. Beccabunga. Herba. (Lond.) Folia. (Dub.) Brooklime. The herb. Willd. g. 44. fp. 30. Diandria Monogynia.—Nat. ord. Perfo. nata. This is a low perennial plant, common in little rivulets and ditches of ftanding water. The leaves remain all the winter, but are in greateft perteaion in the fpring. Their prevailing tafte is an herbaceous one, accompanied with a very light bitternefs. If any good effeas be expeaed from brooklime, it ffiould be ufed as food. VINUM. (Dub.) SeeViTis. VIOLA ODORATA. Flores: Viola. Flos recens. (Lond.) Flores. (Dub.) March violet. The recent flower. Willd. g. 446. fp. 12. Pentandria Monogynia.—Nat. ord. Campanacea. This plant is perennial, and is found wild under hedges and in ffiady places; but the ffiops are generally fupplied from gardens. Its flowers are fo remarkable for their delightful odour, and their peculiar richnefs of color, that they have given a name to both. In our markets we meet with the flowers of other fpecies; thefe may be diftinguifhed from the foregoing by their being larger, of a pale color, and of no fmell. They impart their color and flavor to aqueous liquors; a fy- rup made from this infufion has long maintained a place in the fhops, and is faid to be an agreeable and ufeful laxative for chil- dren ; but is chiefly valued as a delicate teft of the prefence of uncombined acids or alkalies, the former changing its blue to 2 red, and the latter to a green color. VIRGA AUREA. (Lond.) SeeSoLiDAGO. VITIS VINIFERA. Fruclus ficcatus, ejusque fuccusfermen- tatus. (Ed.) < Vitis. Fruclus. Uva paffa, Vinum. Tartarum, Tartari cryfialli. Acetum. (Lond.) Uva paffa. Vinum album Hifpanicum, album Rhenanum, ru- brum Lufitanicum. (Dub.) The Vine. Grapes. Raifins. Wine. Tartar. Cryftals oi tartar. Vinegar. Part II.] Materia Medica. S23 Willd. g. 453. fp. 1. Pentandria Monogynia.—Nat. ord. Hede- raca. 1 he vine grows in temperate fituations in many parts of the world, and is cultivated very generally for the fake of its agree- able fubacid fiuit. Before they are ripe, grapes are extremely harffi and acid, and by expreffion furnifh a liquor v.hich is called Verjuice. It contains malic arid, fuper tartrite of potafs, and ex- tra6tive, and may be made to furnifh w:ne by the addition of fu- gar. As the grape advances to maturity, the quantity of fugar increafes, while that of malic acid diminifhes ; it however r ever difappears entirely. When thoroughly ripe, the grape is one of the moft agreeable fruits. It is cooling, antifceptic, and nutri- tious ; and when eaten in confiderable quantity, diuretic, and gent- ly laxative. In inflammatory difeafes, and all others where acids are indicated, they form an excellent article of diet. Raifins, uva paffa, are grapes which have been carefully dried. By this means not only the water they contained is diffipated, but the quantity of acid feems to be diminiffied. They become more faccharine, mucilaginous, and laxative, than the recent grape, but are lefs cooling. Wine is the juice of the grape altered by fermentation (S 2. 245.) The numerous varieties of wine depend principally on the pro- portion of fugar contained in the muft, and the manner ot its fer- mentation. When the proportion of fugar is fufficient, and th; fermentation complete, the wine is perfect and generous : If the quantity of fugar be too large, part of it remains undecompofed, as the fermentation is languid, and the wine is fweet and lufcious ; if, on the contrary, it be too fmall, the wine is thin and weak ; and if it be bottled before the fermentation be completed, it will proceed flowly in the bottle, and, on drawing the cork, the wine will froth and fparkle in the glafs, as for example Champaigne. When the muft is feparated from the hufk of the grape before it is fermented, the wine has little or no color : Thefe are called white wines. If, on the contrary, the hufks are allowed to remain in the muft while the fermentation is going on, the alcohol dif- folves the coloring matter of the hufks, and the wine is colored : Such ate called red wines. Befides in thefe principal circum- ftances, wines vary very much in flavor. The red wines moft commonly drunk in this country are Port, which is ftrong and auftere, and Claret, which is thinner and higher flavored. Our white wines are all flrong, Madeira, Sherry, Lifbon, Malaga and Hock. Of thefe the laft is the moft acidulous, and Maia,^ the fweeteft. Wine, taken in moderate quantities, aas as a beref c^a! ftimu- lus to the whole fyftem. It promotes digeftion, incre.-its tIk-ac- tion of the heart and arteries, raifes the heat of the tody, and ex- hilirates the fpirits. Taken to excefs, it produces inebriety and 324 Materia Medica. [Part II. ftupor, which are often fucceeded by headach, ftupor, naufeaand diarrhoea, which laft for feveral days. Habitual excefs in wine, debilitates the ftomach, produces inflammation of the liver, weak- ens the nervous fyftem, and gives rife to dropfy, gout, apoplexy, tremors, and cutaneous affeaions. To convalefcents, and in all difeafes of general deb ility, and de- ficiency ot the vital powers, wine is the remedy on w hich we muft place our chief dependance ; arid when properly adminiftered, its effeas are often fcarcely credible. The ufe of wine, as an article of pharmacy, will be aoticed hereafter. VITRIOLUM ALBUM. (Dub.) SeeZiNCUM. WINTERA AROMATIC A. Cortex. (Ed.) Wmferanus. Cortex officinarum. Winter's bark. Willd.g. 1063. P^lyandria Tetragynia.—Nat. ord. Olcracex. This is the produce of a tree growing about the fouthern pro- montory of America. It was firft difcovered on the coaft of Ma- gellan by Capt. Winter, in the year 1,567 ; the failors then em- ployed the bark as a fpice, and afterwards found it ferviceable in the fcurvy; for which purpofe it is at prefent alfo fometimes made ufe of in diet drinks. The true Winter's bark is not often met wjth in the ffiops, Canella alba being generally fubftituted for it, and by fome they are reckoned to be the fame : There is, how- ever, a confiderable difference betwixt them in appearance, and a greater in quality. The Winter's bark is in large pieces, ofa more cinnamon color than the canella, and taftes much warmer and more pungent. Its fmell refembles that of Cafcarilla. Its virtues refide in a very hot, ftimulant, effential oil. ZEDOARIA. (Lond. Dub.) See Amomum. ZINCUM. (Ed. Dub. Lond.) Zinc. This general properties of zinc have been already noticed (164.) It is always found oxidized. I. Combined with a greater or lefs proportion of carbonic acid. Calamine. 2. Combined with fulphur. Blende. 3. Combined with fulphuric acid, generally in folution. The ores of zinc are rarely worked by themfelves, or with the fole intention of extraaing zinc, but are generally melted with the lead ores, particularly galena, which they commonly accom- Part II.] Materia Medica. , 325 pany. By this procefs the zinc is obtained in two forms ; part of it is fublimed in the ftate of an oxide, and attaches itfelf to the chimney of the furnace in the form of a grey, granular, earthy- like incruftation, which is known by the name of Tutty or Cad- mia ; part of it is fublimed in its metallic form, and is condenfed in the throat of the chimney in fmall grains, which are afterwards melted in a crucible, and caft in ingots. Zinc is officinal for the preparation of the white oxide and the fulphate. Oxidum Zinci Impurum. (Ed.) Tutia. (Lond. Dub.) Impure oxide of zinc. Tutty. It is moderately hard and ponderous ; ofa browniffi color, and full ot fmall protuberances on the outfide, fmooth and yellow- iffi within ; fome pieces have a blueiffi caft, from minute glo- bules of zinc in its metallic form. Tutty is celebrated as an ophthalmic, and frequently employed as fuch in unguents and collyria. - Carbonas Zinci Impurus. (Ed.) Lapis calaminaris. (Dub. Lond.) Impure carbonate of zinc. Calamine. This mineral is found plentifully in England, Germany, and other countries, either in diftina mines, or intermingled with the ores of different metals. It is ufually of a greyifh, browniffi, yellowiffi, or pale rediffi color ; without luftre, or tranfparency ; fraaure commonly uneven or earthy ; tonfiderably hard, though not fufficiently fo as to ftrike firewith fteel; fpecific gravity,2.585, but fometimes much heavier. Before the blow pipe it decrepi- tates, but does not melt, and becomes either whiter or yellow. It is partly foluble in acids, and often effervefces with them. In the latter cafe it lofes one third of its weight by calcination. It almoft always contains a confiderable proportion of filica, fome:. times even a third, and often a little oxide of iron. Calamine is generally roafted before it comes into the fliops, to render it more eafily reducible into a fine powder. In this ftate it is employed in collyria, againft defluxions of thin acrid humors upon the eyes, for drying up moift, running ulcers, and healing excoriations. Sulphas Zinci. Vitriolum album. (Lond. Dub.) Sulphate of zinc. White vitriol. This is chiefly found native in the mines of Goflar, fometimes in tranfparent pieces, but more commonly in the form of white ef- fiorefcences, which are diffolved in water, and afterwards reduc- es" 3 * 326 Materia Me dice. [Part II. ed by evaporation and cryftallization into large maffes. We rarely meet with this fort of vitriol pure ; it is ordered therefore to be prepared. White vitriol is fometimes given, from five or fix grains to half a drachm, as an emetic; it operates very quickly, and, if pure, without violence. Externally, it is employed as an ophthal- mic, and often made the bafis of collyria, both in extemporaneous prefcription and in difpenfatories. ZINGIBER. (Lond. Dub.) SeeAMOMUM. APPENDIX. * No.L Listof Substances containedin some of the latest and most esteemed Foreign Pharmacopceias, but not inserted in Me Materia Medica of any of the British Colleges. ----«QOO---- EXPLANATION of the ABBREVIATIONS. R,—Pharmacopoeia Roflica. 8vo. Petropoli, 1798. A. p.—Pharmacopoeia Auftrircoprovincialis, emendata. 8vo. Viennae, 1794. A. c.—Pharmacopoeia Auftriaco caftrenfis. 8vo. Ticini, 1795. B.__Pharmacopoeia in ufum officinarum Reipublicse Bremenfif ctnfcripta. 8vo. Bremac, 1792. $&* 4 328 Materia Medica. [Part II, ■O* Achillea millefolium.'' Miltefolii herba,fiores. R.—A. p.—B. Smell fomewhat aromatic ; tafte flightly aftringent and bitter- iffi ; virtue's ftomachic and tonic. ACHILLEA NOBIL1S. Millefolii nobilis herba,flores. R. Smell camphoraceouS and aromatic, preferable in every refpeft to the preceding fpecies. ACHILLEA PTARMICA. Ptarmica radix ; Herba, cumfioribus, R. No fmell ; tafte acrid ; virtues fialogogue, fternutatory. ADIANTUM CAPPILUS VENERIS. Capillus veneris. Herba. A. p. Ufed for preparing the fyrup called Capillaire. AGARICUSMUSCARIUS. R. Smell fetid ; tafte acrid ; virtues inebriating, and inducing de- lirium. AGR1MONIA EUPATORIA. Agrimonia. The herb. A. p.—B. Slightly ftyptic and aftringent. ALCEA ROSEA. Malva arboreaflores. R.—B. • No fmell ; tafte mucilaginous and fubaftringent ; effeas emol- lient and fubaftringent. AMBRA AMBROSIACA GRYSEA. Ambra gryfea. R. Smell agreeable; tafte refinous and aromatic ;~ effeas exciting and augmenting the nervous power. "amomumgrana paradise Grana paradifi. B. Smell flightly aromatic ; tafte acrid ; aaion ftimulating, AMYGDALUS NANA. Nuclei. R. No fmell ; bitteriffi tafte ; a fubftitute for fweet almonds. ANAGALLIS ARVENSIS. Anagallis. Herba. A. p.—B.—R. No fmell; tafte, at firft herbaceous, afterwards bitter and fome- what acrid. Appen.] Materia Medica. 329 ANEMONE PRATENS1S. Pulfatilla nigricantis herba,. R.—A. p.—B. Smell flight ; tafte acrid, cauftic, durable ; effeas diuretic and ftimulant. ANEMONE NEMO ROSA. Ranunculi albiflores, et herba recens. R. • Smell flight; tafte acrid ; effeas rubefacient and bliftering. ANTIRRHINUM LINARIA. Linaria. A. p.—B. Smell, urinous ; tafte bitteriffi, effeas diuretic. ARISTOLOCHIA CLEMAT1T1S. Ariflolochia vulgaris. Radix. R. Smell fragrant, but heavy ; tafte bitter, durable ; effeas diu- retic, emmenagogue. ARISTOLOCHIA ROTUNDA. Radix. B. Smell, tafte and effeas, fimilar to thofe of the preceding fpecies. ARISTOLOCHIA TRILOBATA. Slipites. Radix. R. Smell, fragrant, ftrong ; tafte bitteriUi, correfponding with the fmell; effect diaphoretic. ARTEMISIA PONTICA. Abfyn'thium ponticum. Herba. A. p. Similar to A. abfinthium but weaker. ASTRAGALUS EXSCAPUS. Radix. R.—A. p._B. No fmell ; tafte bitteriffi and fubaftringent ; effeas demulcent, and fallely fuppofed antifyphilitic. BELLIS PERENNIS. Flos. Folium. A. p. No fmell ; tafte flightly acrid. BETULA ALNUS. Alni folia. R. No fmell ; tafte aftringent and bitterifli; effeas difcutient and vulnerary. BOLETUS LARICIS. Agaricus albus, fungus decorticatus. A. p. Agaricus chirurgorum. B. Tafte naufeous and bitter ; effeas emetic, cathartic, draftic. BOLUS ALBA. A. p. BOLUS ARMENA. A. p. No fmell ; adhere to the tongue ; effeas exficcative. 340 Materia Medica. [Appen. BOS TAURUS. Lac vaccinum. A. p. Nutritious demulcent. Sevum Bovinum. R.—A. c. Unctuous, emollient. BRASSICA (ERTJCA.J Eruca femina. R. Smell heavy ; tafte acrid ; effeas ftimulant. CALENDULA OFFICINALIS. Calendula. A. p. Tafte bitteriffi. CANNABIS SATIVA. Cannabis. Semina. R.—B. Smell weak; tafte mawkiffi ; effeas emollient, anodyne. CARDUUS MARIANUS. Carduus Maria. Semen. B. Emu 1 five, CAREX ARENARIA. Radix. R. Smell agreeable, but not ftrong ; effeas demulcent, refolvent. ' CERATONiA SILIOUA. * ' Sihqua dulcis. R.—A. p.—B. No fmell ; tafte fweet; effeas edalcorant, expeaorant. CHEL.IDONIUM MAJUS. Radix. Herba recens. R.—A. p.-B. Smelt heavy ; tafte acrid, bitteriffi, durable ; effeas acrid, pur- gative ; when dried, aperient, diuretic. CHENOPODIUM AMBROSIOIDES. Chenopodii herba. B. Smell ftrong, fragrant ; tafte acrid, aromatic ; effeas ftimulant, carminative, anthelmintic. CHENOPODIUM BOTRYS. Botrys vulgaris. Herba. R. Qualities and effeas fimilar to, but ftronger than thofe of the preceding fpecies. CICHORIUM 1NTYBUS. Cichorii radix, herba. R.—A. p. et. c.—B. No fmell; tafte of the herb agreeably bitter, of the root intenfc- ly bitter ; effeas aperient tonic, diuretic. Appcn.] Materia Medica. 341 CLEMATIS ERECTA. Flamulde Jovis folia, flores. R.—A. p. Smell weak ; tafte acrid, bliftering ; effeas diuretic, fudorific. CONFERVA DICHOTOMA. Fucus Hdminthocortos. Helminthocorton. R.—B. Smell marine, fetid ; tafte faline ; effeas purgative, anthelmin- tic. CONVOLVULUS AMERICANUS. Mechoacanna. Radix. B. Tafte at firft fweetiffi, then fubacrid ; effea purgative. CUCUMIS MELO. Melo. Semen. A. p. Emulfive. CUCURBITA PEPO. Pepo. Semen. A. p. Emulfive. CYCAS CIRC1NALIS. Sago grana. R.—B. Amylaceous ; nutritious. CYNOMORIUM COCCINEUM. Fungus Melitenfis. R. No fmell; tafte ftyptic, bitteriffi, faline ; effeas roborant, a- flringent. CYT1NUS HYPOCISTIS. Hypocifiii. Succus infpffatus- A. p. Tafte acid ; auftere ; effea aftringent. DICTAMNUS ALBUS. Radix. A. p. —B. Smell fragrant ; tafte bitter, fubaromatic ; effeas tonic, anthel- mintic. EPIDENDRUM VANILLA. Vanilla filiqua. R. Smell fragrant, balfamic ; tafte aromatic, fubacid, unauous ; effeas heating, diuretic. ' EUPHORBIA OFFICINALIS. Euphorbii gummi. R.—A. p. No fmell ; tafte at firft none, then pungent, burning; effeas acrid, dfaftic. ERYSIMUM OFFICINALE. Eryfimum. Herba. B. Tafte acrid ; effeas aftringent, diuretic. 342 Materia Medica. [PartII. FAGARA OCTANDRA. Tacamahaca. Gummi refina. R. Smell fragrant like lavender ; tafte bitteriffi, naufeous ; effeas tonic, ftimulant. FICUS INDICA RELIGIOSA. Lacca gummi. R.—B. Refinous^ FORMICA RUFA. Formica cum acervo. R.—B. Qualities and effeas depend on the little acetous acid they coa- taiu. GADUS LOTA. Muflelafiuviatilis. Liquamen hepatis. A. p. Detergent ; folvent. GENTIANA PANNONICA. Gentiana. Radix. A. p. et c. Qualities and effects the fame as thofe of the gentiana lutea. GEUM R1VALE. Gei palufiris radix. R. Smell weak ; tafte ftyptic, auftere ; effeas tonic, aftringent, fe- brifuge. GEUM URBANUM. Caryophyllata radix. R.—A. p.—B. Smell caryophyllaceous, loft by drying ; tafte ftyptic, bitter; effeas tonic aftringent, febrifuge ; faid to be an excellent fubfti- tute for Peruvian bark. GLECOMA HEDERACEA. Htdera terreflris. Herba. A. p.—B. Tafte bitteriffi, fubacrid ; effeas expeaorant, roborant. HIRUDO MEDICINALIS. Herudo. Animal vivum. A. c. Topical abftraaion of blood. HYPERICUM QUADRANGULARE. Hypericum. Flores. B. Smell agreeable ; tafte bitteriffi, fubaftringent, balfamic ; ef- feas vulnerary. ILEX.AQUIFOLIUM. Aquifolii folia. R. No fmell; tafte aftringent ; effeas febrifuge, antiarthritic. ILL1CIUM ANISATUM. AnifumJlellatum. Fruclus, A. p.—B.—R. AP\ppen.] Materia Medica. 343 Smell aromatic ; tafte agreeable, like anife; effeas peaorai, carminative, diruetic. IMPERATORIA OSTRUTHIUM. Imperatoruz radix. R.—A. p.—L. Smell aromatic; tafte warm, pungent, very durable; effeas ftim- ulant, carminative, fudorific, diuretic. JASMINUM OFFICINALE. Jafmini flores. R.—B. Smell fragrant; tafte bitteriffi ; ufed as a perfume. LEDUM PALUSTRE. Rorifmarinifylveflris herba. R.—A. p. Smell heavy, fubaromatic ; tafte bitteriffi, fubaftringent \ effeas refolvent, diruetic. LICHEN ISLANDICUS. A. p. et. c—B.—R. No fmell ; tafte bitteriffi, fubaftringent ; effea nutritious- LIGUSTICUM LEVISTICUM. Leviflici herba, radix, femen. R.—A. p.—B. Smell unpleafant; tafte warm, aromatic ; effeas ftimulant, car- minative, fudorific. LIQUIDAMBAR STYRACIFLUUM. Styrax liquida. Balfamum. A. p. Smell fragrant; tafte acrid, aromatic ; effeas ftimalating, heat- ing. LONICERA DIERVILLA. Diervillaflipites. R. Tafte and fmell naufeous ; effeas antivenereal. LORANTHUS EUROPiEUS. Vifcum quercinum. Lignum. A. p. Smell naufeous ; tafle aftringent, mucilaginous ; effeas tonic. LYCOPERDON BOVISTA. R. No tafte or fmell ; effeas mechanical, fuppreffion of h«emorr- hagy. LYCOPODIUM CLAVATUM. Lycopodii femen. R.—B. No tafte or fmell ; effeas abforbent. LYTHRUM SALICARIA. Lyfimachia purpurea. Herba. B. Salicaria. A. P; No fmell ; tafte fubaftringent ; effeas aftringent, tonic MANGANESIUM. Magnefia nigra. R. Magnefia vitrariorum. A. p. \ 344 Materia Medica. Part II.]' Properties, fee (169,) ufed, for the produaion of oxygen gas, oxymuriatic acid, and fome other chemical preparations. MARANTA GALANGA. Galanga radix. R.—A. p.—B. Smell fragrant ; tafte aromatic, pungent, biting ; effeas ftom- achic, heating. MATRICARIA CHAMOMILLA. Chamomilla vulgaris flores, herba. R.—A. p. ef. c.—B. Smell ftrong ; tafte bitter, warmiffi ; effeas ftomachic, difcu- tient. MATRICARIA PARTHENIUM. Matricaria. Flos, Herba. A. p. Smell naufeous ; tafte bitter ; effeas ftomachic. MELOE PROSCARAB^EUS. A. p. Melde majalis. B. Vermis majalis. R. No fmell j tafte acrid ; effeas ftimulating, diuretic, cauftic. MENTHA CR1SPA. Herba. R.—A. p.—B. Smell fragrant, ftrong ; tafte warm, aromatic, flightly bitter ; effeas refolvent, ftomachic, carminative. MENTHA AQUATICA. Mentha rubra. Oleum diflillatum. A. c. Similar to the former. MIMOSA SENEGAL. Arabicum gummi. B. Suppofed to produce the fineft gum arabic. MYROBALANUS CITR1NA. Cortex fruBuum pulveri- fatus. Terminali a fpecies f A. p. Tafte aftringent; effeas aftringent. NIGELLA SATIVA. Nigella. Semen. B. Smell fragrant; tafte acrid, aromatic ; effeas ftimulating, er- rhine, fialogogue, anthelmintic. ONONIS SPINOSA. Ononis radix. A. p. No fmell; tafte fweetiffi ; effeas diuretic. ONOPORDUM ACANTHIUM. Cardui tomentofiherba recens. R. No fmell; tafte bitteriffi ; effects fpecific, the cure of cancer. ous affeaions. Appen.] Materia Medica. 345 ORCHIS MASCULA, MORIO, MILITARIS, MjACU- LATTA, PYRAMIDAL1S, LAT1FOL1A. Salep. Satyrium. Radix. R.—A. p. et c.—B. Tafte amilaceous ; effeas nutritious. ORIGANUM DICTAMNUS. Diclamnus Creticus. Herba. B. Smell flight, aromatic ; tafte aromatic ; effeas ftimulant. ORYZA SAT1VA. Oryza femen decor tic at urn. R. Tafte farinaceous ; effeas nutritious, aftringent, PjEONIA OFFICINALIS. Paonia radix. R.—B. Smell unpleafant ; tafte at firft fweetiffi, then difagreeably bit- ter ; effeas antifpafmodic. PECHURIM FAB A. Ex Lauro quadam. R. Smell fragrant, durable; tafte aromatic; effeas ftomachic, aftringent. PHELLANDRIUM AQUATICUM. Semen. R. Faniculum aquaticum. B. Smell heavy; tafte aromatic, acrid ; effeas ftimulating, refoi- vent. PHYTOLACCA DECANDRA. Phytolacca herba recens, radix. R. No fmell; tafte acrid, corrofive ; effeas corrofive in cancer. PIMPINELLA SAXIFRAGA. Pimpinella alba radix. R.—A. p.—B. Smell fragrant ; tafte warm, acrid; effecfs ftomachic, diapho- retic, diuretic. PINUS PINEA. Pinusfativa, Nuclei. A. p. Tafte fweet, bland ; effeas nutritious. PLANTAGO MEDIA. Plantago. Herba. A. p. Tafte fubaftringent; effects aftringent. PLANTAGO PSYLLIUM. Pfyllii femen. R. Tafte naufeous, mucilaginous, then acrid ; effea» relaxant. POLYGALA AMARA. Herba, radix. R.—B. 346 Materia Medica. [Part II, No fmell ; tafte bitter, acidulous, mucilaginous; effeas demul- cent, roborant. POLYGALA VULGARIS. , Poly gala. Radix. A. p. Tafte fweetiffi, bitter ; effeas tonic, expeaorant. POLYPOD1UM VULGARE. Polypodii radix. R.—A. p.—B. y Tafte at firft fweet, then naufeous, bitterand aftringent; effeas* demulcent, refolvent. POPULUS BALSAMIFERA. Tacamahaca. Gummi refina. R. Smell fragrant, tafte naufeous, bitteriffi j effeas ftimulant, to. nic. v PRUNUS CERASUS. Ceraforum rubrorum acidorum frudus. R.—B. Ceraforum nigrorum aqua. A. p. - Tafte acidulous, fweetiffi ; effeas refrigerating, antifeptic; wa- ter narcotic. PRUNUS LAURO CERASUS. v Lauro cerafi folia. R.—B. Smell fragrant ; tafte bitter like that of bitter almonds ; effects highly deleterious, narcotic, refolvent, diuretic. PTERIS AQUILINA. y Fihcisfamina radix. R. Smell naufeous ; tafte vifcid, bitteriffi ; effeas anthelminlhic. RHEUM UNDULATUM. Rkabarbari Sibirici radix. R. Smell flight; tafte bitter and flightly au^irfgent ; effeas ftoma- vchic, purgative. RUBUS ARCTICUS. Bacca. R. Smell fragrant ; tafte acidulous, vinous; effeas refrigerant, antifcorbutic. Similar properties are poffeffed by the fruits %{ the rubus idaus, cafinusfrutlicofus, chamamorus. RUMEX AQUATICUS. Lapathi aquatui radix. R. Tafte auftere, bitter ; effeas tonic, antifcorbutic, RUMEX ACUTUS. Lapathum acutum. Radix. A. p.—B. Tafte bitterifli, acidulous; effeas aftringent, * Appcn.] Materia+Medica. & S47 * SALIX ALBA, PENTANDRA, FRAG1LIS, V1TELLL NA. Sa!:rii cortex. R. Smell ffagrant; tafte aftringent, bitter ; effeas tonic, febrifuge. SAMBUCUS EBULUS. -» Ebulus. Radix. A. p. A Smell fetid ; tafle naufeous, bitter, acrid ; effeas draftic, ca- thartic, emetic, narcotic. ,.> >■ ? SAPONARIA OFFICINALIS.* •* Saponaria radix. R.—A. p. et. c.—B. No fmell ; tafte flightly fweet, bitter and glutinous; effects de- tergent. '* SCABIOSA ARVENSIS. ^Scabiofa. Folium. A. p. - Tafte flightly bitter ; effeas expeaorant, vulnerary. SCANDIX CEREFOLIUM. Cerefolii herba. Succus. B.—A. p. » Smell weak, balfamic'; tafte aromatic, balfamic ; effeas ape* rient, peaorai, diuretic. ' SCORZONERA HISPANICA. t^Scorzonera. Radix. A. p. Tafte fweetiffi ; effeas aperient, demulcent. SCROPHULARIA NODOSA. Scrophularia. Folium. Radix. A. p. ^ * Smell unpleafant ; tafte naufeous, bitter ; effeEh attenuant. * SEC ALE CEREALE. > . Secalisfarina. A. p. Tafte farinaceous ; effeas nutritious, SEMPERVIVUM TECTORUM. - Sedi majoris folia virentia. R.—A. p#--B. Smell weak; tafte fubacrid, flight^ ftyptic; effeas refrige- *• rant, aftringent. •:• SEPIA OCTOPODA. . Sepia, os. B. k A carbonate ot lime agglutinated by animal mucilage. SMILAX CHINA. , China radix. A. p.—B. ♦ No fmell ; tafte mucilaginous; effba's fudorific, antivenereal, -^ SPIGELIA ANTHELMIA. Herba cum radice.R.~-B. , Tafte and fmell fetid ; effeas narcotic, purgative, anthelmintic < Y 4&■ ■ *348 ^Materia■ f^edica. [Part II. *STRYCHNOS NUX VOMICA. Nux vomica. No fmell ; tafte intenfely bitter ; effeas tonic, narcotic, dele- terious. SYMPHITUM OFFICINALE. Symphiti radix. R. Confolida major. A. p.—B. No fmell; tafte mucilaginous ; effects emollient, infpiffant. 'TEUCRIUM CHAM EDRYS. Crta.madryos herba. R.—A. p.—B. \ Smell Highly fragrant ; tafte bitter; effeas tonic, emmen- agogue. TEUCRIUM CHA1S&EPITYS. thamapityos herba. R. Smell fragrant ; tafte bitter and aromatic ; effeas tonic. THEOBROMA CACAO. 4 Cacao. Nucleus. Oleum. R.—A. p.—B. Little fmell; tafte pleafant and oily, very flightly aftringent and bitteriffi ; efftcts nutricious. Oil bland, fweetiffi ; effeas tmol- lient, lubricating. THYMlis SERPYLLUM. Strpylli herba. R.—A. p.—B. SmefU fragrant ;'fafle aromatic, bitteriffi ; effeas ftimulant, diu- retic, emmenagogue. & : THYMUS VULGARIS. Thy mi heffaz. R.—B. Smell fragrant; tafte warm, pungent, bitter ; effeas ftimulant, diuretic, emmenagogue. TRJFOLIUM MELILOTUS OFFICINALIS. * Melxloti herba cum floribus. R.—A. p.—B. Smell fragrant; tafle herbaceous, bitteriffi ; effeas difcucient. TRITICUM REPENS. Graminis radix. ' R.—A. p. et cl—B. * Smell herbaceous"; tafte fweetiffi ; effeas aperient, demulcent. VACCINIUM MYRTILLUS. Myrtillt baccie. R.—A. p. < * No fmell ; tafte acidulous, fubaftringent ; effeas refrigerant, ; Jf: aftringent". • '♦•* VACCINIUM OXYCOCCOS. Oxy^cci.bacca. **R. Tafte acidulous; effeas refrigerant. Jf.V « Appen.] Materia Medica. 349 VACCINIUM VlTISIDiEA. Vitis idaa bacca folia. R. Tafte acidulous ; effetts refrigerant, antifeptic. VERATRUM SABADILLA. Sabadilla femen. R.—-A. p. et. c.—B. '• Tafte very bitter, acrid and cauftic ; effeas ftimulant, draftic, cathartic, anthelmintic, errhine. VERBASCUM THAPSUS. Verbafciflores, folia. R.—A. p.—B. Tafte of the leaves, herbaceous, bitteriffi ; effeas emollient, difcutient. Smell ct the flowers fweet; tafte fweet; effeas pec- toral. VICIA FABA. Faba. Semen. A. p. Tafte farinaceous; effeas nutritious; VIOLA TRICOLOR. Herba. R.—A. p. Jacea. Herba. B. ' T«Smell agreeable ; tafte mucilaginous, bitteriffi ; effeas anodyne^ VITIS VINIFERA APYRENAJ' Papula minores. R.—B. Tafte fweet, acidulous ; effeas refrigerant, demulcent, lubricat- ing, **»« No. II. List of Animals which furnifh articles of the Materia Medi- ca, arranged according to CuviER'sfyfiem. '■f V MAMMALIA; Rodentia. Caftor fiber. Pachydermata. Sus fcrofa. / Ruminantia. Mofchus mofchiferus. Cervus elaphtUs.— Ovis aries. Bos taurus. Cetacea Phyfeter macrocephalus. AVES. Galling. Phafianus gallus. Anseres. Anas anfer. 35Q Materia Medica. -[Part II. : ' PISCES. Chondropterygii. Acipenfer fturio, ftellatus, hufo, ru- thenus. ^ $ CRUSTACEA. Canceres. Cancerpagurus, aftacns. INSECTA. Coxeoptera. Lytta veficatoria. (Meloe vificatorias) Me- loe profcarab as us. Hymenoptera. Cyhfps querci folii. Apis mellifera. For- mica ru fa. *f* Hemiptera. Coccus caai. Gnathaptera. Onifcusafellus. MOLLUSCA. Cephalopoda. Sepia officinalis. Atephala. OflffeB edulis. \ -VERMES. Hirudo medicmalis. ZOOPHYTA. ( Ceratophyta. Gorgonia nobilis. (Ifiis nobilis.) Spongia. Spongia officinalis. No. III. List »fthe Gen era of'Medicinal Plants, arranged according to the LinNjEN Syfiem. Cl, I. MONANDRIA. Cl. II. DIANDRIA Ord. Monogynia. Ord. Monogynia.*1* Kzempferia. OJea. Araomum. Gratiola. Curcuma, Salvia. Veronica. Rofmarinus. *? Appen.] Materia fiedica. # 351 Cl. II. DIANDRIA. Ord. Trigynia. Piper. Cl. III. TRIANDRIA. Ord. Monogynia. v Valeriana. * Iris. Crocus. Ord. Digynia. Saccharum. Secale.^ ^ Hordeum. Avena. Triticum. Cl.IV. TETRANDRIA. Ord. Monogynia. Plantago. Rubia. Alchemilla. Scabiofa. Santalum. Dorftenia. Ord. Digynia. Cufcuta. Cl. V. PENTANDRIA. Ord. Monogynia, Anchufa. Spigelia. Datura. Nicotiana. Capficum. Atropa. Lobelia. Rhamnus. Viola. Menyanthes. Convolvulus. Hyofciamus. Strychnos. Solanum. Cinchona. Cl. V. PENTANDRIA. Ord. Monogynia. Cephaelis. Vitis. Ribes. v Old.JDlGYNIA. Gentiana. Eryngium. Conium. Cuminum. Bubdn, , *. Coriandrum. ^ Paftinaca. Apium. Ulmus. Daucus,.r» Sium. Ferula. . Angelica. Carum. Anethum. PimpiaelUv Ord. Trigynia. Sambucus. Rhus. Ord. Pentagynia. Linum. ** y» Cl. VI. HEXANDRIA. Ord. Monogynia. Allium. Scilla. Atee. Calamus. Lilium. Dracaena. Acorus. Berberis. Ord. Trigynia, Rumex. Colchicum, IK't m * 352 '« Materia Medica. [Part II, Cl. VII. HEPTANDRIA. Ord. Monogynia. yEfculus. Cl. VIII. OCTANDRIA. Ord. Monogynia. Amyris. $ Daphne. - .* Vaccinium, Ord. Trigynia. Polygonum. Cl. IX. PENNEANDRlA. Ord. Monogynia. Laurus. .Ord. Trigynia. Rheum. Cl. X. DECANDRIA. Ord. Monogynia. Caffia. Guajacum. Toluifera. Swietenia. Rhododendron. Styrax. Myroxylon. -*Rnta. Hgematoxylon. Quaffia. Arbutus, Cppaifera. Ord. Digynia. Dianthus. Cl. XI. DODECANDRIA. Ord. Monogynia. Afarum. Canella. Cl. XII. ICOSANDRIA. Ord. Monogynia. Caaus. Myrtus. ' 6^4 CI. XII. ICOSANDRIA. Ord. Monogynia. Amygdalus. Eugenic!. Punica. Prunus. ■ Ord. PentagYnia. Pyrus. Ord. Polygynia. Rofa. Tormentilia. Geum. Rubus. Potentilla. Cl. XIII. POLYANDRIA. Ord. Monogynia. Papaver. Ord. Trigynia. Delphinium. Acomtum. Ord. Tetragynia. Wintera. Ord. Polygynia. Helleborus. Cl. XIV. D1DYNAMIA. Ord. Gymnospermia. t Hyffopus. Lavandula. Marrubium, Mentha. Teucrium. Meliffa. Ord. Angiospermia. Digitalis. Cl. XV. TETRADYNA- ^ MIA. Ord. SiliculoSjE. ; Cochlearia. 4. Appen.] Materia Media-:. 353 Cl. XV. TETRADYNA- MIA, Ord. Siliquos.«, Tt Raphanus. Sinapis. Cardamine. Sifymbrium. M Cl. XVI. MONAbftpHIA. Ord, Triandria. Tamarindut. Dolichos. ' Geoffroya" Trigone lla.l? Spartium. Glycyrrhiza/ ~Aftragalus. Cl.^XVIII. POLYADEL, PHIA. *'■" Ord. ICOSANDRIA. Citrus. Ord. POLYANDRIA. Melaleuca. Hypericum. Cl. XIX. SYNGENESIA. Ord. Polygamia Mqua- LIS* Laftuca. ArBium. Ceoiuodon. Cynara. £1. XIX SYNGENESIA. * Ord. PolygamiaSuper elua. Tanacetum, Tuffila«>. ^ ■ Inula. Matricaria. Achillea. ( Arternifia. " Solidago. ' Arnica. Anthemis. O.Polygamia.Frustra N EA. •* Centaurea. Ord. Monogamia. * Lobelia. Viola. C1*XX. GYNANDRIA, Ord. DlANDRIA. Orchis. Ord. Hexandria. Ariflplochia. Ord. Poly an dr i a. Ajurn. Cl. XXI. MONPECIA. Ord. Tetr'andriaV( Betula, *' Morus. Urtica. ■* 'f- Ord. POLYANDRIA. Quercus. Juglans. Ord. MoNApELPHIA, Pinus. Ricinus. Croton. Ord. SYNGENESIA. Momordica. 55"4 Materia- Medica. Part II.] Cl. XXI. MONOECIA. Ord. Syngenesia. Cucumis. ' Cucurbita, Bryonia. *W C1.XX1I. DIOECIA, v Ord. DlANDRIA. • Salts. Ord. Pentandria. Piltacia. Cl. XXIII, POLYGAMIA, ** Ord. Monoecia, • Mimofa. Parietaria.^ >% Ord. DlOECiA. Fraxinus. Panax.^V Ord. Hexandria. Smilax. % ** Ord. Tr'ioecia. ^ Ficus. Cl. XXIV. CRYPTOGA MIA. Ord. Filices. Polypodium. Ord. Monadelphia. Juniperus.* ' Ord. Fungi. Ciffampelos. Boletus. C\. XXIII. POLYGAMIA. Cl. XXV. PAI^MiE, Ord. Monoecia. Veratum, Cocos, * >®4fr*< No. IV. «* Lifi ofOffcinal Plants, arranged according to their Natural Orders, ^vProfeffor Murray of Gottingen. «. Ord. I. CONIFER/E. Pinus. Juniperus. Old. II. AMENTACE^E. Salix. Juglans. i* Quercus. Betula. Piftacia. Ord. III. COMPOSITE. a. Capitate. Araiura. Cynara, oI#: m. composite, Centaurea. b. Semiflosculosa, Leontodon. T Laauca. Jf* C. DlSCOIDEiE. Artemifia. Tanacetum. Tuffilago- d. Radiate, . | Anthemis. Inula. '• * Arnica. Solidago. „ *H Appen.] Materia Medica. 355 Ord. IV. AGGREGATE. Valeriana. Cephaelis. «» Ord. V. CONGLOMERA. % T.E. Penaea. > OrdV VI. UMBELLAT/E. Eryngium. Daucus. # %* Conium. £ Ferula. >%. Angelica. Sium. Bubon. ■.„<• " Cuminum. ♦ Coriandrum. * *> Paft inaca. • Anethum. Carum. Pimpinella. Apium. I Ord. VII. HEDERACE.E, Vitis. ^ Panax. Ord. VIII. SARMENTA- £EJE. I j. Smilax. rCiffampelos. Ariftolochia. Afarum. Oro\ IX. STELLATE. ' Rubia. Pflpigelia, Ord. X. CYMOS.E. -* Ord. XI.CUCURBITA. QEJE. * Cucumis. Momordica. Bryonia. Ord. XII. SOLANACEiE, Solanum, Ord. XII. SOLANACE-^, Atropa. Hyofciamus. •' Datura. Nicofiana. Capficum. Digitalis, Ord.XIlL CAMPANACEiE. Convolvulus. ,. Lobelia. Viola. Orel XIV. CONTORTS. Cinchona. Ord, XV. ROTACE.E. Gentiana. Menyanthes. Orel. XVI. SEPIARLE. Olea, Ord. XVII. BlCORNES, , Arbutus. Rhododendron. Styrax. Ord. XVIII. ASPERIFO- LUE. ; Anchufa.1^ Ord. XIX. VERTICILLA. TiE. Teucrium. Meliffa^ Hyffopus. Lavandula. Origanum. Mentha. Marrubium. Salvia. Rofmarinus. Ord. XX. PERSONATE Gratiola. Veronica. * 356 Materia Medica. Ord. XXI. RHOEADE^.. Papaver. Ord. XXII. PUTAMINE.E. [Part II. Ord. XXIII. SILIQUOS^. Sifymbrium. Cardamine. Raphanus. Sinapis. Cochlearia. Ord. XXIV. PAPILIONA- CE^E. Dolichos. Spartium. / Glycyrrhiza, ^Aftragalus. Trigonella. Pterocarpus. Geoffroy a. Ord. XXV. LOMENTA- CEjE. Caffia. Myroxylon. Toluifera. Mimofa. Tamarind us. Heematoxylon. Polygala- » Fumaria. Ord. XXVI. MULTISILU QUJE. Aconitum. Delphinium. Helleborus. Ruta. Ord. XXVII. SENTI.pOSiE. Potentilla. Tormentilla. Rubus. Rofa. Ord. XXVIII. POMACEiE. Pyrus.1 Prunus. Amygdalus, Punica. Citrus. Ribes. Ord.XXIX HESPER1DEA. Myrtus. Melaleuca. #■ Caryophyllus. Ord. XXX. SUCCULEN- .. T^E O. XXKI. COLUMNIFE. R./E. % Althaea. i\ Malva. ^ Ord. XXXII.GRUINALES, Gudiacum. Quaffia. Linum. Oxalis. *» Ord. XXXIII. PHYLL.E. Dianthus. CARYO. *< Ord. XXXIV. CALYCAN> THEM^. Ord. XXXV. ASCYROI- de,e. Ciftus. Hypericum. ,trd| Fraxinus. * Ord. XXXVI. COADUNA- TjE. Ord. XXXVII. DUMOSjE, Rhamnus. Sa nbucus. Rhus. 1>v t * Appen.^J Materia Ord. XXXVII. DUMOSiE. 1 Amyris. Copaifera. Ord. XXXVIII. TRIHILA- TiE. Swietenia. iEfculus. Berberis. .Ord. XXXIX.TRICOCCiE Stalagmitis. Croton. Ricinus. Ord. XL. OLERACE^. Rumex. Rheum. .Polygonum. Laurus. Myriftica. Wintera. Canella. Ord. XLI. SCABRIDGE. ** Parietaria. Dorftenia. Ficus. Urtica. Morus. Ulraa. Ord.XLIL VEPRECUL^E. Daphne. Ord. XLIII. PALM.E. Cocos. Ord. XL1V. PIPERITA. Piper. ** Acorus. Arum. * » Medica. 357 Ord. XLV. SCITAMINE/E, Amomum. Curcuma. Ksempferia. bid. XLV I. LILIACE.E,. Lilium. Scilla. Allium. Vera! rum. Colchicum. Crocus. Aloe. Ord. XLVII. ENSAT'iE. Iris. Ord.XLVIII. ORCHIDE.E. Orchis. Ord. XLIX. TRIPETALOI- DE^E. Calamus. Ord. L. CALAMARLE. Ord. LI. GRAMINA. Triticum. Hordeum. Avena. Saccharum. Ord. LII. F1LICES. Polypodium. Ordt'LIII.MUSCI. Ord. L1V. ALG.E. Ord. LV. FUNGI. Boletus. 358 Materia Medica. [Partil. No. V. Lifi of Subfiantes belonging to the Mineral Kingdom, ujhkh are ufed in Medicine. EARTHS. Lime. Carbonate of lime, Chalk. Marble. Baryta. Carbonate of baryta. Sulphate of baryta. Bole. Alumina. SALTS. Sulphate of magnefia. Super fulphate of alumina and potafs. Sulphate of iron.* of copper. SALTS. Sulphate of zinc. Nitrate of potafs. Muriate of foda. INFLAMMABLES, Bitumen. Amber. Sulphur. METALS, Silver. Copper. Iron. Tin. Lead. Mercury. Zinc. Antimony, Arfenic. V PART III. PREPARATIONS AND COMPOSITIONS. *. CHAP I. SULPHUR. ■ . Sulphur sublimatum lotum. ^ Edin. Flores Sulphuris Loti. Lond. . Wafhed Sublimed Sulphur. Wafhed Flowers ef Sulphur. Take of Sublimed fulphur, one pound ; Water, four pounds. Boil the fulphur for a little in the water, then pour off this water, and wafh away all the acid by affufions of cold water; and laft- ly dry the fulphur. Sulphur Sublimatum Lotum. Dub. Wafhed Sublimed Sulphur. Let warm water be poured upon fublimed fulphur, and thrtrafflamg- jf-he repeated as long as the water, when poured off, is impreg- nated with acid. When dried, it is to be kept in well clofed veffels. As it is impoffible to fublime fulphur in veffek perfectly void of air, a fmatl portion of it is always acidified and convened imo j fulphurous or fulphuric acid. The prefence of acid in falphur, / is always to be conOdered as an impurity, and muft be removed by careful ablution. Whenthorou jhly walked, (uhlimsi fufyhar. :s $60 Preparations and Compositions. [Pail Hf a£ied upon by the atmofphere ; there is therefore no particular reafon for preferving it from the action of the air; for if, on keep. ing, it become moift, it is becaufe the fulphuric acid has not been entirely wafhed away. SULPHUR PRiECIPITATUM. Lond. Precipitated Sulphur. Take of Sulphurated kali, fix ounces ; Diihlied water, one pound and an half; Diluted vitriolic acid, as much as is fufficient. Boil the fulphurated kali in the diftilled water until it be diflbhr-^ ed. Filter the liquor through paper, to which add the diluted™ vitriolic acid. Wafh the precipitated powder by repeated af;^ fufions of water till it become infipid. Bubi Take of Sulphurated vegetable alkali, four ounces; Boiling water, a pound and a half ; Diluted nitrous acid, as much as may be fufficient. Diffolve the fulphurated vegetable alkali in the water, and add the acid to the filtered liquor as long as the liquor is rendered twrbid by its addition. Wafh the precipitated powdag well with warm water, and keep it after it is dried in well clofed vef. fels. We fliall have another opportunity of mentioning more parti- cularly the a£Hon of potafs and fulphur on each other. When the fulphuretted potafs is thrown into water, it is entirely diffolvedj but not without decompofition, for it is converted into fulphate. of potafs, hydroguretted fuiphuret of potafs, and fulphuretted hy- droguret of potafs. The two laft compounds are again decom- pofed on the addition ot any acid. The acid combines with the potafs, fulphuretted hydrogen flies off in the form of gas, while fulphur is precipitated. It is of little confequence wh^t acid is employed to precipitate the fulphur. The London College order the fulphuric, probably becaufe a portion of it is already contai|- ed in the folution ; while the Dublin College ufe nitrous acid, becaufe the nitrate of potafs formed, is more eafily wafhed away than the fulphate of potafs. Precipitated fulphur does not differ from well wafhed fublimed fulphur, except in being much dearer. Its paler color is owingi | to its more minute divifion ; but from this circumftance it derives \ no fuperiority to compenfate for the difagreeablenefs of the pre- paration. •$ i /■; . Chap. II.] AM. • 361 CHAP. II. ACIDS. ACIDuM SULPHURICUM DILUTUM. Edin. Diluted Sulphuric Acid. Take of Sulphuric acid, one part; Water, feven parts. Mix them. AfllDUM Vitriolicum Dilutum. Lond.. Diluted or weak Vitriolic Acid. Take of Vitriolic acid, one ounce ; Diftilled water, eight ounces. Mix them by degrees. Dub. Take of Vitriolic acid, two ounces ; x% Diftilled water, fourteen ounces. Having gradually mixed them, fet them afide to cool, and then pour off the clear liquor. The moft fimple form in which fulphuric acid can be advan- tageoufly employed internally, is that in which it is merely diluted , with water ; and it is highly proper that there fhoqld be tome fix- ed ftandard in which the acid in this ftate fhould be kept. It is, however, muc£ to be regretted, that the colleges have not adopt- ed the fame ftandard with refpeft to ftrength : 'For in the Edin- burgh and Dublin Colleges, the ftrong acid conftitutes an eighth ; and in the London, only a ninth of the mixture. The former pro- portion we are inclined to prefer, as it gives exactly a drachm of acid to the ounce ; but the dilution by means of diftilled water is preferable to fpring water ; which, even in its pureft ftate, is not free from impregnations affe£ling the acid. Sulphuric acid has a verf flrong attraction for water; and their bulk*when combined is lefs than that of the water and acid fepa- rately. At the fame time, there is a very confiderable increafe ojf temperature produced, which is apt to crack glafs veffels, unlefs the combination be very cautioufly made ; and for the fame rea- fon, the acid muft be poured into the water, not the water intqthe acid. ,' i , 362 Preparations apd- Compositions. [Part III.' ACIDUM NITRQSUM. Edin. ^f. ^ ... Nitrous Acid. • * Take of Verypurenitrate of potafs. two pounds; Sulphuric acid, fixteen ounces. Having put the nitrate of potafs into a glafs retort, pour upon it the fulphutic acid, and diftil in a fami bath, with a heat gradual. ly increafed, until the iron pot begins to be red hot. The fpecific gravity of this acid is to that of diftilled water al io5Q to io©o. Lond. Take of Purified nitre, by weight, fixty ounces ; 1 Vitriolic acid, by weight, twentynine ounces. * Mix and diftil. ^ The fpecific gravity of this is to the weight of diflilled water'as *» 155° to 1000. - Dub. Take of *■ Nitre, fix pounds; Vitriolic acid, three pounds. Mix and diftil, until the refiduum becomes dry* The fpecific gravity of the acid is to the weight of dtftilled wa- ter as 1,550 to 1000. In this procefs, the fulphuric acid, by its fuperior affinity, com. bines with the potafs of the nitre to form fulphate of potafs, while the nitric acid is feparated, and is not only converted into vapor by the application ot the heat to the retort, but is alfo partially decompofed. A portion of oxygen efcapes in a gafeotis form, and the nitric oxide gas combines with the nitric acid ; fo that the liquor condenfed in the receiver is nitrous and not nitric acid. In performing this jprocefs, we muft take care, in pouring in the fulphuric acid, not to foil the neck of the retort. The difference of the proportions of the ingredients directed by the different Col- leges, has no effecl: on the quality ef the acid obtained, but only affecls the refiduum. The London and Dublin Colleges ufe no more fulphuric acid than what is neceffary toexpel all the nitric acid, and the refiduum is a neutral fulphat^ of potafs, fo infoluble, that it cannot be got out without breaking the retort. The Edinburgh * College order as much fulphuric acid as renders the refiduum, an acidulous fulphate of potafs, eafily foluble in water. Nitrous acid is freqeently impure. Sulphuric acid is detected by the precipitate formed on dropping into it a little nitrate of ba- X Chap. !.l:j 'Acids. ' 363 s ryta, and is eafily got rid of by rediftilling the nitrous acid from a fmall Quantity ot nitrate of potafs. Muriatic acid is detefted by the precipitate formed with nitrate of filver, and may be feparated by dropping into the nitrous acid a folution of nitrate of filver, as long as it forms any precipitate, " and drawing off the nitrous acid by diftillation. The general properties of nitrous acid have been already notic- ed (183.) Mr. Davy has fhewn that it is a compound of nitric- acid and nitric oxide, and that by additional dofes of the laft con- * ftituent, its color is fucceffively changed from yellow to orange, olive green, and blue green, and its fpecific gravity is diminifhed. The fpecific gravity is probably ftated too high by the Colleges ; for although Rouelle makes that of the ftrongeft nitric acid 1,583. ' 'yet Kirwan could produce it no ftronger at 6o° than 1.5543, anc* Mr. Davy makes it only 1.504, and when faturated with nitric oxide only 1.475. ACIDUM NITROSUM DILUTUM. Lond. Dub. Edin. Diluted Nitrous Acid, Take of Nitrous acid, Water, equal weights. Mix them, taking care to avoid the noxious vapors. Nitrous ac id has a great affinity for water, and attrafts it from the atmofphere. During their combination there is an increafe of temperature, part of the nitric oxide is diffipated in the form of noxious vapors, and the color changes fucceffively from orange to green, and to blue, according as the proportion of water is in- creafed. A mixture of equal parts of Kirwan's ftandard acid oi 1.5543 and water, has the fpecific gravity 1,1911. ACIDUM NITR1CUM. Edin. Nitric Acid. Take of Nitrous acid, any quantity. Pour it into a retort, and having adapted a receiver, apply a very gentle heat, until the reddeftportion fhall have paffed over, and the acid which remains in the retort fhall have become nitric acid. We have already ftated, that nitrous acid is nitric acid com- bined with a variable proportion of nitric oxide. 2N0W, by the application of a gentle heat, the whole of the nitric oxide is vaporized, and pure colorlefs nitric acid remains in the re- rtort. The nitric oxide, however, carries ov«r with it a portion Z . * 364 Preparations and Compositions. [[Part. III. of the acid, 2nd condenfes with it in the receiver, in the form of . of fulphuric acid. Fumes of oxygenized muriatic acid are imme- diately difengaged. ftt- $ 1 ;S6S Preparations atul Compc^'ibns., [Part III, < • ACIDUM ACETOSUM DESTILLATUM ' Edin. * Diflilled Acetous Acid. ' i Let eight pounds of acetous acid be diftilled, in glafs veffel^ with a gentle heat. The two firft pounds which come over, being too watery, are to be fet afide; the next four pounds will be the diftilled acetous acid. The remainder furnifhes a ftill ftronger acid, but too much burnt by the fire. ACetum Destillatum. Dub. M Diflilled Vinegar. ,,' Take of 'Vinegar, ten pounds. Draw off, with a gentle heat, fix pounds. The fpecific gravity of this acid is to the weight of diftilled.wa-* ter as 1004 to iooo. Lond. Take of Vinegar, five pounds. Diftil with a gentle fire, in glafs veffels, fo long as the drops fall free from empyreuma. t . Vinegar, when prepared from vinous liquors by fermentation, befides acetous acid and water/contains extractive, fupertartriteof potafs, and often citric or malic acid, alcohol, and a pecdfiar agred. 1. able aroma. Thefe fubftances, particularly the.extra£tive andfu-j^j pertartrite of potafs, render.it apt to fpoil, and unfit for pharma. ceutic and chemical purpofes. By diftillation, however, the ace* \ toui acid is eafily feparated from fuch ot thefe fubftances as are not volatile. But by diftillation it lofes its agreeable flavor, ariig becomes confiderably Weaker; for water being rather more vola™ tile than acetous acid, it cOrpeif over firft, whilethe laft and ftrong. eft portion of the acid carfnot be obtained free from empyreuma. This procefs may be performed either in a common ftill or in a retort. The better kinds of wine vinegar fhould be used ; thofe prepared from malt liquors, however fine and clear they may feem to be, contain a large quantity of a vifcous fubftance, as appears from the fliminefs and ropinefs to which they are very fubje6L f This not only hinders the acid from rifing freely, but is apt to make the vinegar boil over into the recipient, and at the fame time difpofes it to receive a difagreeable impreffioti from,the fire.* Indeed, with the beft kind of vinegar, if the diftillation be carried on to any great length, it is extremely difficult to avoid empyreu- ma ,.* The beft method of preventing this inconvenience is, if a retombe ufed, to place the fand but a little way up its fides, and when fomewhat more than half the liquor is come ov«r, to Chap. II.] Acids. * s69 ■'"- . $' pour on the remainder a quantity of frefh vinegar equal to the liquor drawn'off. This may be repeated three or four times ; the vinegar fupplied at each time being previoufly heated. The addition'of cold liquor would not only prolong the operation, but alfo endanger the breaking of the retort. j Lowitz recommends the addition of half an ounce of recently burnt and powdered charcoal toeach pound of vinegar in the ftill, as the beft means.of avoiding empyreuma. If the common ftill be employed, it fhould likewife beocca- fionally fupplied with frefli vmegar.in proportion as the acid runs off; and this continued until the procefs can be conveniently car- ried no farther. The diftilled acid muft be reaified by a fecond "dt.ftillation in a retort or glafs alembic ; for although the head and receiver, be of glafs or ftone ware, the acid will contract a metal- lic taint ff&m the pewter worm. The refiduuTrvof this procefs is commonly thrown away as ufe- Jefs ,i.i,nn»i, ;f"/L.;if.illi.- mcn^apA it mav hp made to turn to ffood accout Mixed . committed to diftillation in ajetort, with a- well regulated fiie, it yieldsvan exceedingly" ftrong acid, together with an empyreuma- tic oil, which taints the acid with a difagreeable odor. This acid is neverthelefs, without, any rectification, better for fome; purpofes, as being ftronger, than the pure acid ; particularly for making acetite of potafs or foda ; for then the empyreumatic oil, on wfntSh.its ill flavor depends, is burnt out. / Diftilled vipegar fhould be colorlefs and transparent ; have a - pungent fmell>nd purely acid tafte, totally freedom acrimony and empyreuma, and ffiould be entirely volatile-: It fhould not ; form a black precipitate-on the addition of a folution of Lai)ta, or of water, faturated, with fulphuretted hydrogen ; or change its K color when fuper faturSM. with ammonia. Thefe circumftances fhew, that it is adulterated Wlth^ulphuric acid, lead^copper, or tin. Diflilled acetous acid in its effeas on the animal economy, docs not differ from vinegar, and as it is lefs pleafant to the tafle, it is only ufed for pharmaceutical preparations. ACIDUM ACETOSLJM FORTE. Edin. Strong Acetous Acid. Take of Sulphate of iron dried, one pound ; Acetite of lead, ten ounces. Having rubbed them together, put them into a retort, and diftil in a fand bath with a moderate heat, as long a? any acid comes over. (5~a 4 *> ■ t "' .

.^ Take of Benzoin, in powder, one pound ; Carbonate of foda, four ounces ; Water, four pounds. Diffolve the carbonate in the water, and digeft the benzoin in the folution for twenty four hours with a gentle heat ; then boil it for a quarter of an hour, and filter the folution while hot. After it cocls drop into it fulphuric acid as long as any precipitate is produce. Separate the precipitate by filtration, and wafh it with cold water. If itbe deferable to have the acid cryftallized, the' precipitate may be diffolved by boiling it gently in twentyfour times its weight of water, filtering it as hot and quickly as poffi- ble, and fetting it afide to cryftallize. But as the cryftallized, acid, on account of its lightnefsand elafticity, is not eafily reduc* ed to powder, for moft purpofes it will be more convenient to keep it in the ftate of a precipitate. It may be alfo extraaed from ftorax, and all the other balfams, particularly thefe of Tolu or Peru ; and from the urine of chil- dren, and of herbivorous animals. The benzoic acid has an agreeable tafte, and a fragrant fmell, efpecially when heated. It is foluble in alcohol and in boiling water; but.rvery fparingly in cold water, although it may be fufpended in it by means of fugar, {o as to iorm an elegant bal- famic fyrup. OLEUM SUCCINI et ACIDUM SUCCINI. ;j. Edin. *w Oil of Amber and Succinic Acid, Take of Amber reduced to powder, and. of pure fand, equal parts. Mix them, and put them into a glafs retort, of which the mixture mayfill one half ; t^ien adapt a large receiver, and diftil in a fand bath, with a fire gradually increafed. At firft, a watery liquor will come over, with fomeyeliow oil ; then a yellow oil with an acid fait, and laftly, a reddifh and black colored oil. Pour the liquor out of the receiver, and feparate the oil from the water. Prefs the fait colleaed from th.e neck of the retort and fides of the receiver between folds of blotting paper, to free it from the oil adhering to it ; then purify it by folution in warm water and crvftallization. Chap. II.] Acids. P,Z Sal Succini. Dub. Salt of Amber. Take of Amber, Pure fand, each one pound. ^Dtftil; with a heat gradually increafed, an acid liquor, an oil, and a fait difcoloured with oil. Let the fait be diflolved in boiling water, and cryftals formed by flow cooling. Sal et Oleum Succini. Lond. Salt and oil of Amber. Take of Amber, two pounds. Diftil in a fand heat gradually augmented ; an acid liquor^.oil, and fait loaded with oil, will afcend. Sal Succini Purificatus. Lond. Purified Salt of Amber. Take of Salt of amber, half a pound ; Diftilled water, one pint. Boil the fait in diftilled water, and fet afide the folution to fery-;y ftallize. We are not acquainted with any experiments which determine/. whether the fuccinic acid exifts as fuch in the amber, or whether it be a produa of the decompofition of the amber by the aaion of heat, for in the procefs employed for obtaining fuccinc acul, the amber is completely decompofed. : } According to Gottling.this diftillation fhould be performed ina-Vdr tubulated iron or earthen ware retort, expofed to the immediate ^ aaion of the fire ; for he fays, that, in a fand bath, we carmut reg- . ulate the heat fufficiently, and that a glafs retort is iacapable ©f fupporting the'neceffary temperature. Befides the fuccinic acid colleaed f^om the rieck of the re- tort, and fides of the receiver, the oil wafhes down a portion of it into the receiver, and the watery liquor which comes over is faturated with it. But the w'hole of it may be obtained by agi- tating the oil with fome boiling water, which will diffolve the acid. This folution is then to be added to the acid liquor, and the acid they contain is eafily obtained by evaporation and cryftalli- zation. The whole acid may then be purified by folution in boil- ing jvater and chryftallization, according to* the direaions of the Colleges. * ft 374 Preparations and Compositions. [Part III. <„But even after repeated folutions. aud cryftallization*, a portion of empyreumatic oil ftill adheres to the acid, and renders it im- pure. Other methods of purifying it have been therefore at- tempted. Demachy faturated it with lime, feparated the lime by fulphuric acid, and fublimed the fuccinic acid : Richter faturated Succinic acid with potafs, decompofed the fait formed with acetite of lead, and. difengaged the fuccinic acid from the lead by means t of diluted fulphuric acid : Laftly, Morveau afferts that he obtain- ed it in a ftate ot perfea purity, by treating it with nitrous acid. Succinic acid, although retained in our pharmacopceias, is nev- er ufed in medicine. AQUA AERIS FIXI. Dub. Acidum Carbonicum. Water impregnated with Fixed Air. Carbonic Acid. Take of White marble in powder, three ounces ; Diluted fulphuric acid, mixed with an equal quantity of water, a pound and a half. Mix them gradually in a Nooth's apparatus, and let the air evol- ved pafs through fix pounds of pure fpring water, placed in the upper part of the aoparatus ; and let agitation be occafionally employed until the water have acquired a fubacid tafte. In this procefs the carbonic acid is feparated from the carbo- nate of lime by the fuperior affinity of fulphuric acid. As it is difengaged, it affumes a gafeous form, and would be diffipated in the atmofphere, if it were not made to pafs through water, which, at a medium temperature, is capable of abforbing about an equal bulk of this gas, and, by the affiftance of preffure, a much great- er proportion. Various contrivances have been made for this purpofe. Of thefe the moft eafily managed and moft convenient for general ufe, is the apparatus of Nooth, already defcribed (p. 114.) and for larger quantities that of Woulfe, defcribed p. 113, or fome modification of it. By the proper application of preffure, M, Paul of Geneva, now of London, is able to impregnate water with no lefs than fix times its bulk of carbonic acid gas. . Water impregnated with carbonic acid, fparkles in the glafs, has'a pleafant acidulous tafte, and forms an excellent beverage. It diminifhes thirft, leffens the morbid heat of the body, and aas as a powerful diuretic. It is alfo an excellent remedy in increaf- ed irritability of the ftomach, as in advanced pregnancy ; and it is one of the beft antiemetics which we poffefs. Chap. III.] Alkalies. 375 CHAP. III. ALKALIES. AQUA POTASS^L; vulgo, Lixivium Causticum. Edin. Water of Potafs* commonly called Caufiic Ley. Take of Frefh lime, eight ounces ; Carbonate of potafs, fix ounces. Throw the lime into an iron or earthen veffel, with twentyeight,. ounces of warm water. After the ebullition is finifhed, inftantly add the fait; and having thoroughly mixed them, cover the vef- fel till they cool. When the mixture has cooled, agitate it well, and pour it into a glafs funnel, whofe throat muft be ftopt up with a piece of clean rag. Let the upper mouth of the funnel be cov- ered, while the tube of it is inferted into another glafs veffel, fo that the folution of potafs may gradually drop through the rag in- to the lower veffel. When it firft gives over dropping, pour in- to the funnel fome ounces of water ; but cautioufly, fo that the water may fwim above the matter. The ley will again begin to drop, and the affufion of water is to be repeated in the fame man- ner, until three pounds have dropped, which will happen in the fpace of two or three days ; then agitating the fuperior and infe- rior parts of the ley together, mix them, and put them up in a well ftopt phial. Aqua Kali Puri. Lond. Water of pure Kali. Take of Prepared kali, four pounds ; Lime, fix pounds; Diftilled water, four gallons. Put four pints of water to the lime, and let them ftand together for an hour ; after which, add the kali and the reft of the #ater ; then boil for a quarter of an hour ; fuffer the liquor to cool, and ftrain it. A pint of this liquor ought to weigh fixteen ounces. If the liquor effervefce with any acid, add more lime, and boil the liquor and lime in a covered veffel for five minutes. Laftly, let it cool again, and ftrain it. 376 Preparations and'Compos itions^ [Part III. 4 Lixivi.um Causticum. ' J" . Dub. Cauftic Ley. x Tdke of -iK t FYefh burnt lime, eight ounces ; Mild vegetable alkali, fix ounces. Put the lime into an earthen veffel, and throw upon it thirty ounces of hot water. With the flaked lime immediately mix the fait, and cover the veffel. Pour the mixture as foon as it has cooled into a glafs funnel, whofe throat is obftruaed with bits of ftone covered with fand. Having covered the funnel, let the ley drop into a veffel placed to receive it ; water being from time to time poured into the funnel", until three pounds have paffed through Let the liquor be agitated, and kept in a glafs veffel well clofed. ^ If the ley be rightly' prepared, it will have neither color nor fmell, and will not effervefce when mixed with acids. The fpecific gravity of this liquor is to that of diftilled water as 1090 to 1000. These proceffes do not differ Ihatjerially. They are founded upon the ftronger affinity of lime than that of potafs for carbonic acid. Of courfe, when,lime comes in contaa with carbonate of potafs* the carbonic acid quits the potafs to unite with the lime, and the refults of the mixture are potafs and carbonate of lime. Now, as the carbonate of lime is infoluble in water, and the pot* afs is very foluble, they may be feparated by filtration. In do- ing this, however, we muft take care to employ inftruments on' which the folution of potafs does not aa, and to prevent the free •accefs ot air, from which it would attraa carbonic acid, and thus fruftrate the whole operation. The latter objeft is attained by covering the upper or broad end of the funnel with a plate ot glafs, and inferting the lower end in the neck of a phial, which it fiis pretty clofely. The former objea is attended with greater difficulties, and indeed fcarcely to be effeaed, fo powerful and gen- eral is the agency of potafs. All animal fubftances are immedi- ately attacked and deftroyed by it ; therefore, our filters cannot be made of filk, woollen, or paper which contains glue ; and al- though neither vegetable matters nor filica entirely efcape its ac- tion, linen and fand are, on the whole, the leaft objeaionable. A filter of fand was ufed by Dr. Black. He firft dropt a rugged pebble into the tube of the funnel, in fome part of which it form- ed itfelt a firm bed, while the inequalities on its furface afforded interftices of fufficient fize for the paffage of the filtering liquor. On the upper furface of this ftone he put a thin layer of lint or clean tow ; immediately above this, but not in contaa with it, he dropped a ftone fimilar to the former, and ofa fize proportioned Chap. III.] Alkalies.*. 377 V to the fwell in the upper part of the tube of the funnel. The in- terftices between the fecond ftone and the funnel'were filled up with ftones of a lefs dimenfion, and the gradation uniformly con- tinued till pretty fmall fand was employed. Finally, this was covered with a layer of coarfer fand and fmall ftones to fuftaiu the weight of the matter, and to prevent- its being invifcated in the minute interftices of the fine fand. A filter of fand being thus conftruaed in the funnel, it. was walhed perfeaiy clean by making clean water pafs through it, till it dropt from the lower extremity of the funnel perfectly clear and tranfparent; and before ufing it, it fhould be allowed to ftand for fome days, that no water may remain among the intcrltiqes of the fand. From the fpongy nature of the refiduum which remains upon the filter, and efpecially it we ufe that of fand, a confiderable'( quantity of the folution of potafs will be retained. It is.-'howev.." er, eafily obtained, by pouring gently over it, fo as to difturb it as little as potable, a quantity of water ; the ley immediately be- A' gins again to drop from the funnel, and as, Irom the difference of their fpecific gravity, the water does not mix^with it, but fwims above* it, the whole ley paffes through before anv of the water. By means of the tafte we eafily learn when the whole ley has paffed. As it is natural to fuppofe that the ftrongeft fojution will pafs firft, and the weakeft laft, we are direaed to agitate the whole to- gether, to render their ftrength uniform. '*■ If the folution of potafs be pure, it wjjl be colorlefs, and it will neither effervefce with acids, nor form a preeepitate with car- bonate of potafs. If it effervefces, carbonic acid is prefent, arid muft be feparated by again boiling the folution with a little lime, or by dropping into it lime water, as long as it produces any pre- cipitate. If, on the contrary, it contain lime, from ioo much of it having been employed in the preparation, it may be feparated by dropping into the ley a folution of the carbonate of potafs. When we have thus purified our folution of potafs, it muft be again fil- tered. « The folution of cauftic potafs, under various names, has at dif- ferent times been celebrated as a lithontriptic, and as often fallen again into difufc. The very contradictory accounts ot.'its efL-ds as a folvent are now in fomedegreeexplicable, fince it has been dif- covered that urinary calculi are very different in their natures, fo that fome of them are only foluble in acids, and others only in alkalies. Ofthe laft defcription are the calculi of uric acid, which are very frequent, and thofe of urate of ammonia. On thefe therefore, alkalies may. be fuppofed to make fome impreffion ; and that alkalies, or alkaline carbonates, taken by the mouth, luveoccafionally relieved calculous complaints, is certaiu. It is \ 378 Compositions and Prepartions. £ Part III. however faid, that their continued ufe debilitates the ftomach ; and M. Fourcroy has propofed applying the remedy immediately to the difeafe, by injeaing into the bladder a tepid folution of potafs or foda, fo dilute that it can be held in the mouth. Before the alkaline folution be injeaed, the bladder is to be completely eva*- cuated of urine, and wafhed out with an injeaion of tepid water* After the alkaline injeaion has remained in the bladder half an hour or more, it is to be evacuated, and allowed to fettle. If, on the addition of a little muriatic acid, a precipitate be formed, we «» fhall have reafon to conclude that the calculus contains uric acid, and that the'alkali has aaed on it. Very dilute alkaline folutions may alfo be.4aken into the ftom- ach as antacids, but we poffefs others, which are preferable. Externally, alkaline folutions have been more frequently ufed, either very dilute, fimply as a ftimulus, in rickets, gouty fwelf- ings, gonorrhoea, and fpafmodic difeafes, or concentrated as a cauf- tic to deftroy the poifon ot the viper, and of rabid animals. POTASSA ; olim, Causticum Commune Acerrimum. Edin. Potafs; formerly, Strongefi Common Cauflic. Take of The folution of potafs, any quantity. Evaporate it in a covered very clean iron veffel, till, on the ebul-, lition ceafing, the faline matter flows gently like oil, which hap* pens before the veffel becomes red. Then pour it out on a , fmooth iron plate ; let it be divided into fmall pieces before it hardens, and immediately placed in a well ftopt phial. Kali Purum. Lond. Pure kali. Take of Water of pure kali one gallon. Evaporate it to drynefs ; after which let the fait melt on the fire and pour it out. Alkali Vegetabile Causticum. Dub. Cauflic Vegetable Alkali. Take of . Cauftic ley, any quantity. Evaporate it over the fire in a very clean iron veffel, until the ebullition having ceafed, the faline matters, on increafing the heat, remain almoft at reft. Let the liquified fait be poured out upon an iron plate, and while it is congealing be cut into proper Chap. lit] Alkaline Salts'. 37$ proper, pieces, which are immediately to be fhut up in very ,'- clofe veffels. 7 ' The principal thing to be attended to in this operation, is to condua the evaporation fo rapidly that the ley fhall not abforb ««ny carbonic acid from the atmofphere. As long as any water of folution remains, the ebullition is evident, and the evaporation is to be continued until it ceafe. The heat then to be increafed a little, which renders the potafs perfeaiy fluid, and gives it the ap- pearance of an oil, when it is ready to be poured out, either on a flab, as directed by the colleges, or into iron moulds, fuch as are ufed for the melted nitrate of filver. P The potafs prepared according to thefe direaions is fufficiently pure for medical ufe/but is not fit for chemical experiments. We can however, obtain it perfectly white and cryftallized, according to Betrhollet, by adding to the ley, when evaporated fo far that it would affume the confiftence of honey if permitted'to cool, a quantity of alcohol equal to one third of the carbonate of potafs operated on, mixing them together, and letting them boil a min- ute or two. ., The mixture is then to be poured into a glafs veffel and corked up, when the impurities will gradually fubfide, part- ly in a folid form, and partly diffolved in water. The fuperna- tant alcoholic folution is then \o be evaporated rapidly, till, its furface become covered with a black cruft, which is,tobe remov- ed, and the liquid below is to be poured into a porcelain veffel, when it will concrete into a white fubftance, which is to be brok- en in pieces, and immediately excluded from the aaion of the air. , A lefs expenfive way of obtaining potafs perfeaiy pure is that ofLowitz'. Evaporate a folution of potafs till a thick pellicle form on its furface; allow it to cool; feparate all the cryftals formed, as they confift of foreign falts; renew the evaporation in ^an iron or filver bafon ; and remove the pellicles which form oh' the furface with an iron fkimmer, as long as any appear. When the ebullition ceafes,'remove the veffel from the fire, and agitate the fufed fait with an iron fpatula while it cools. Diffolve the faline mafs in twice its weight ot water, and evaporate in a,filver bafon till it begins to cryftallize. The cryftals are pure potafs. * The fluid which fwims over them has a dark brown color, andt muft be poured off; but if kept in a clofe ftopt phial, it will de- pofite its coloring matter, and by evaporation will furnifli more cryftals of potafs. Potafs is only ufed as a catfftic, or to form folutions of a known ftrength ; and even its ufe as a cauftic is inconvenient, from its being fo quickly affeacd by the air, and from its rapid deli juef- cence, which renders it apt to'fpread. A A! 380 Preparations and Compositions. [Part lit POTASSA CUM CALCEjolim Causticum Commune Mil ius Edin. Potafs with Lime, formerly Milder Common Cauflic. Take of Solution of potafs. Evaporate in a covered iron veffel till one third remains ; then mix with it as much new flaked lime as will bring it to the confiftence of a pretty folid pap, which is to be kept in a veffel clofely ftopt. Calx cum Kali Puro. Lond. Lime with Pure Kali. Take of Quicklime, five pounds and four ounces ; Water of pure kali, fixteen pounds. Boil away the water of pure kali to a fourth part; then fprinkle in the lime reduced to powder by the affufion of water. Keep it in a veffel clofely flopped. Causticum Minus. Dub. Milder Cauflic. Evaporate cauftic ley to one third, then add powdered lime till it it become thick, and form into proper maffes. . The addition of the lime in thefe preparations renders them lefs apt to liquefce, more eafily managed, and milder in their op- eration. CARBONAS POTASSES. Edin. Carbonate of Potafs. Let impure carbonate of potafs, called in Englifh Pearl afhes, be put into a crucible, brought to alow red heat, that the oily impurities, if there be any, maybe confumed; then triturate it with an equal weight of water, and mix them thoroughly by agitation. After the feces have fubfided, pour the liquor into a very clean iron pot, and boil to drynefs, ftirring the fait to- wards the end of the procefs, to prevent its flicking to the veffeli Kali Pr^eparatum. Lond. Prepared Kali. Take of Potafhes, two pounds ; Boiling diftilled water, three pints. y Chap. III.] Alkaline Salts. 3&1 Diffolve and filter through paper; evaporate the liquor till a pel- licle appears on the furtace ; then fet it afide for twelve hours, that the neutral falts may cryftallize ; after which, pour out the liquor, and boil away, with a flow fire, the whole of the Water, conftantly ftirring, left the fait fhould adhere to th-; pot. In like manner is purified impure kali from the afhes of any kind of vegetable. The fame fait may be prepared from tartar, which fhould be burnt till it becomes of an afh colour. Alkali Vegetabile Mite: Dub. Mild Vegetable Alkali. Take of • Potafhes, Boiling water, each fix pounds. Mix them by agitation in a glafs veffel, and digeft them for three days. Then pour off the pure liquor, and evaporate it to drynefs in a very clean iron veffel. Towards the end of the operation, ftir the faline mafs conftantly with an iron fpatula. Then fepa- rate, by means of a fieve, the finer particles, Which are to be kept ih a glafs veffel well flopped. Carbon as PotassjE PurissiMus ; olim, Sal Tartari. Edin. Pure Carbonate of Potafs, formerly Salt of Tartar. Take of Impure fUper tartrite of potafs, any quantity. Burn it to a black mafs, by placing it among live coaJ^. either Wrapped up in moift bibulous paper, or contained in a crucible. Having reduced this mafs to powder, expofe it in an open cruci- ble to the aaion of a moderate fire, till it become white, or at leaft of an afh grey color, taking care that it do not melt. Then diffolve it in warm water ; ftrain the liquor through a linen cloth, and evaporate it in a clean iron veffel, diligently ftirring it towards the end of the procefs with an iron fpatula, to prevent it from Ricking to the bottom ot the veffel. A very white fait will re- main, which is to be left a little longer on the fire, till the bottom of the veffel becomes almoft red. Laftly, when the fait is grown Cold, keep it in glafs veffels well ftopt. The potafhes of commerce we have already fhewn (p. 177. to contain a confiderable proportion of foreign falts, By the pro- cefs direaed by the Colleges, it is purified from thofe which are cjryftallizable ; and although it ftill contains muriate of potafs and filica, it is fufficiently pure for the purpofes of medicine. ^S*2 Preparations and Compositions. [£art lit. The pureft carbonate of potafs in common ufe is that obtained by incinerating the impure fuper tartrite of potafs, as all the fub- ftances it contains, except the potafs, are decompofed by the heat. The tartarous acid and coloring matter are deftroyed, and part of the carbonic acid, which is formed, unites with the potafs. The white and red forts of tartar are equally fit for the puf- pofe; the only difference is, that the white affords a fomewhat larger quantity than the other ; from fixteen ounces of this fort, upwards of four ounces of carbonate of potafs may be obtained. The ufe of the paper is to prevent the fmaller pieces of the tartar from dropping down into the afh hole, through the interftices of the coals, upon firft injeaing it into the furnace. The calcination of the fait (if the tartar was fufficiently burnt at firft) does not increafe its ftrength fo much as is fuppofed; nor is the greenifh or blue color any certain mark, either of its ftrength, or of its having been,'as was formerly fuppofed, long ex- pofed to a vehement fire ; for if the crucible be perfeaiy clean, clofe covered, and has flood the fire without cracking, the fait will turn out white, though kept melted, and reverberating ever fo long ; while, on the other hand, a flight crack happening in the crucible, or a fpark of a coal falling in, will in a few minutes give the fait the color admired. The color, in faa, is a mark rather of its containing fome inflammable matter, than of its ftrength. But this falts, in whatever way obtained, is not ftriaiy entitled \ to the appellation of carbonates; for it is not faturated with the acid, or rather it is a mixture of carbonate of potafs and potafs, in variable proportions. It is owing to the uncombined potafs that it is ftill deliquefcent, and in fome degree cauftic. It may be ea- fily faturated, however, with carbonic acid, by expofing it in fo- lution to the contaa of the air for a confiderable time, or by mak- ing a ftream of carbonic acid gas pafs through a folution of it, or by diftilling it with carbonate of ammonia. In this ftate it is cryf- tallizable, and its cryftals are permanent. It confifts of about 4.3 acid, 40 potafs, and 17 water: The faturation with carbonic acid •is one of the beft means ot purifying it; for it always feparates filica from the uncombined alkali. Carbonate of potafs is frequently employed in medicine, in conjun&ion with other articles, particularly for the formation of faline neutral draughts and mixtures: But it is ufed alfo by it- felf in dofes from three or four grains to fifteen or twenty; and it frequently operates as a powerful diuretic, particularly when1 aided by proper dilution. Chap. III.] Alkaline Salts. 3S& AQUA KALI PRJEPARATI. Lond. Water of Prepared Kali. Take of Prepared kali, one pound. Set it in a moift place till it deliquefce, and then ftrain it, Lixivium Mite. Dub. Mild Ley. Take of Mild vegetable alkali, one pound. Diffolve it in one pound of water. The laft of thefe preparations is a folution of the mixed or fub- carbonate of potafs, in a fixed proportion of water ; and the form- er in a folution of carbonate of potafs.in a variable quantity of wa- ter. The Dublin folution contains the filica, and all the other im- purities of the carbonate employed, while according to the Lon- don procefs, the uncombined portion of the potafs, at the fame time that it deliquefces, becomes faturated with carbonic acid, and depofits the filica. It would, therefore, be a very inconfiderable improvement of this preparation, to diffolve cryftallized carbon- ate of potafs in a determinate proportion of water. AQUA SUPER CARBONATIS POTASS^. Edin. Solution of Super Carbonate of Potafs. Take of Water, ten pounds ; Pure carbonate ot potafs, one ounce. Diffolve and expofe the folution to a ftream of carbonic acid, arifing from Carbonate of lime in powder, Sulphuric acid, each three ounces ; Water, three pounds, gradually and cautioufly mixed. The chemical apparatus invented by Dr. Nooth, is well adapted to this preparation. But if a larger quantity of the liquor be required, the apparatus of Dr. Woulfe is preferable. Liquor Alkali Vegetabilis Mitissimi. Dub. Solution of Mildefl Vegetable Alkali. Take of Mild vegetable alkali, an ounce and a half; Water, fix pounds. Mix them, and tranfmit fixed air through the liquor, according to the formula for preparing fixed air (p. g74.)except that a double fcT 3 384 Preparations and Compositions. [Part. III. quantity of marble and acid muft be employed to faturate the folution. The colder thr air is, and the greater preffure, the better is th: rnly more pleafant to the tafte, but is f'fs apt to off nd the ftom».. i. Indeed, it is the only form in wh ch ve can exhibit potafs in fufficient dofes, and for a fuffirient ■engihot time, to derive much benefit from its ufe in calculous complaints.- It has certainly been frequently of advantage in ihefe af'-'tions, but probably only in thofe inftances in which u~ Aone confi As of uric acid, or urate of ammonia ; for although .... .faturated with carbonic acid, yet the affinity of that acid for potafs is fo weak, that it really operates as an alkali. Six or eight ounces may be taken two or three times a day. It in general proves powerfully diuretic, and fometimes produces* inebriation. This laft effea is afcribed to the carbonic acid. ACETIS POTASS^. Edin. Acetite of Potafs. Take of Pure carbonate of potafs, one pound. Boil it with a very gentle heat, in four or five times its weight of diftilled acetous acid ; add more acid at different times, fill, on the watery part of the preceding quantity being nearly dif- fipated by evaporation, the new addition of acid ceafes toraife any effervefcence, which will happen, when about twenty pounds of the diftilled acetous acid have bei n confumed. It is then to be flowly dried. The impure fait lemaining, is to be melted with a gentle heat, for a ffiort time ; and afterwards dif- folved in water, and f;':ered through paper. If the liquefaftion has been properly performed, the- filtered liquor will be lim- pid ; but it otherwife ; of a brown color. Afterwards evap- orate this liquor with a very gentle heat in a very fhallow glafs veffel, occafionally ftirring the fait as it becomes dry, that its moifture may be fooner diffipated. Laftly, the Acetite of pot- afs ought to be kept in a veffel very clofely ftopt, to prevent it torn deliquefcing, - * Chap. III.] Alkaline Salts. 385 Kali Acetatum. Lond. Acetated Kali. Take of Prepared kali, one pound. Boil it, with a flow fire, in four or five times its quantity of dif- tilled vinegar ; and when the effervefcence ceafes, add, at dif- ferent times, more diftilled vinegar, until one portion of vinegar being nearly evaporated, the addition of another will excite no effervefcence, which will happen when about twenty pounds of diftilled vinegar are confumed ; afterwards let it be dried flowly. Aa impure fait will be left, which is to be melted for a little while with a flow fire ; then diffolved in water, and fil- tered through paper. If the fufion has been rightly performed, the ftrained liquor will be colorlefs ; if otherwife, ofa brown color. Laftiv, evaporate this liquor with a flow fire, in a very fhallow glafs veffel ; frequently ftirring the mafs, that the fait may be more completely dried, which fhould be kept in a veffel clofe- ly ftopt. The fait ought to be very white, and diffolve wholly, both in wa- ter and fpirit of wine, without leaving any feces. If the fait, although white, fhould depofit any feces in fpirit of wine, the folution fhould be filtered through paper, and the fait again dried. Alkali Vegetabili Acetatum; olim,Sal Diuretic us. Dub. Acetated Vegetable Alkali, formerly Diuretic Salt. Take of Mild vegetable alkali, any quantity. Add to it, at different times, about five times its weight of diftill- ed vinegar, at a moderate temperature. When the evaporation ceafes, and the liquor is fomewhat evaporated, add, at inter- vals, diftilled vinegar, until the mixture fhall entirely ceafe to effervefce. Then evaporate to drynefs ; and having increafed the fire a little, bring the faline mafs Into a ftate of fufion. Diffolve the fait, after it has cooled, in water ; filter the folu- k tion, and evaporate, until, on cooling.'it fhall concrete into a chryftalline mafs, which fhould be very white. Put this, while ftill warm, into veffels accurately clofed. This is both a troublefome and expenfive preparation, for when attempted to be made by fimply evaporating to drynefs, the fait has always a dark, unpleafant color, which cannot be removed by repeated folution and cryftallization, or even by folution in alcohol. It is doubtful to what the color is owing. It has been afcribed by fome to part of the acetous acid being decompofed by heat during the exficcation of the fait : They accordingly re- £T 4 380 Preparations and Compositions. [Part III, commend the evaporation to be conduaed very gently, and the pellicles to be fkimmed from the furface of the liquor as faft as they are formed ; and in this way, they fay, they have procured at once a very white fait. Others afcribe it to fome foreign matter which rifes in diftillation with tbe laft portions of the acetous acid, and therefore direa, that only the firft portions which come over fhould be ufed, or that the acetous acid fhould be diftilled with charcoal ; while others again afcribe it to accidentalimpurities contraaed during the operation, and recommend the uttnoft at- tention to cleanlinefs, and the ufe of earthen veffels. To what- ever caufe it may be owing, and the fecond appears to us the moft orobable, the color is moft effeaually deftroyed by bringing the fait into fufion. The heat neceffary to do this decompofes the coloring matter ; and on diffolving the fufed mafs in water, and filtering the folution, we find a fine light charcoal on the filter. But this fufion is attended with confiderable lofs, for part of the acetous acid itfelf is decompofed. The operator muft be particularly careful, in melting it, not to ufe a greater heat, nor to keep it longer liquefied, than what is ab- folutely neceffary ; a little fhould be occafionally taken out, and put into water ; and as foon as it begips to part freely with its black color, the whole is to be removed from the fire. The exficcation of the folution of the fait, after it has been fufed, muft be conduaed very carefully, as it is exceedingly apt to be decompofed, which would render a new folution and exficcation neceffary. The teft of its purity, by diffolving it in alcohol, as direaed by the London College, is to difcover if any of the ace- tous acid itfelf has been decompofed in the operation ; for the carbonate of potafs, which is in that cafe formed, is infoluble in aldohol. To fpare trouble and expence, attempts have been made to pre- pare acetite of potafs with undiftilled, vinegar, and even with the refiduum of the diftillation ot acetous acid ; and they have been to a certain degree fuccefsful ; but as repeated tufion and cryftal- lization are neceffary to bring the fait to a fufficient degree of pu- rity, it does not appear that they were more economical. But if to acetite ot potafs prepared with impure vinegar, we add a fufficient quantity of fulphuric acid, by diftillation we obtain an acetous acid of great ftrength, which forms a beautiful acetite of potafs without fufion. Laftly, this fait maybe prepared by the decorn. pofition of acetites ; for example, of the acetite of lead by carbo- nate of potafs, or ftill better by fulphate of potafs. Acetite of potafs has a fharp, fomewhat pungent tafte. It is foluble at 6o°, in about its own weight of water. It is alfo folu- ble in alcohol. It is deliquefcent. It is decompofed by the ftronger acids ; by a decoaion of tamarinds ; by the fulphate of foda and magnefia ; by muriate of ammonia j by the tartrite of (Chap. III.] Alkaline Salts 38? foda and potafs ; and by fome metalline falts. Its acid is deftroyed by a high temperature. Acetite of potafs, which way Soever prepared, provided it be properly made, is a medicine of great efficacy, and may be fo dofed and managed as to prove either mildly cathartic, or power- fully diuretic ; few of the faline deobftruents equal it in virtue. The dofe is from half a fcruple to a drachm Or two. A bare mixture, however, of alkaline fait and vinegar, without exficca- tion, is perhaps not inferior as a medicine to the more elaborate fait. Two drachms of the alkali, faturated with vinegar, have been known to occafion, in hydropic cafes, ten or twelve ftools, and a plentiful difcharge of urine, without any inconvenience. N1TRUM PURIFICATUM. Lond. NlTRAs POTASSjE. Nitrate of Potafs. Putrified Nitre. Take of Nitre, two pounds ; Diftilled water, four pints. Boil the nitre in the water, till it be diffolved ; ftrain the folu- tion, and fet it afide to cryftallize. Common nitre contains ufually a confiderable portion of mu- riate of foda, which in this procefs is . feparated, tor it remains diffolved after the greateft part of the nitrate of potafs has cryf- tallized. The cryftals which fhoot after the firft evaporation, are large, regular and pure ; but when the remaining liquor is further evaporated, and this repeated a fecond or third time, the cryftals prove at length fmall, imperfea, and tipt with little cubical cryf- tals of muriate of foda. SULPHAS POTASSiE ; olim Tart arum Vitriolatum. Edin. Sulphate of Potafs, formerly Vitriolaled Tartar. Take of Sulphuric acid, diluted with fix times its weight of water, any quantity. Put it into a capacious glafs veffel, and gradually drop into it, of pure carbonate ot potafs, diffolved in fix times its weight of water, as much as is fufficient thoroughly to neutralize the acid. The effervefcence being finifhed, ftrain the liquor through pa- per ; and after evaporation fet it afide to cryftallize. Sulphate of potafs may be alfo conveniently prepared from the refiduum ot the diftillation of nitrous acid, by diffolving it in warm water, and faturating it with carbonate of potafs., 588 Preparations and Compositions. [Part III. Kali Vitriolatum. Lond. Vitriolated Kali. Take of The fait which remains afrer the diftillation of thenitrous acid. two pounds. Diftilled water, two gallons*. Burn out the fuperfluousacid with a ftrong fire, in an open veffel; then boil it a little while in the water ; ftrain and fet the liquor afide to cryftallize. /Vlkali Vegetabile Vitriolatum. Dub. Vitriolated Vegetable Alkali. Let the fait which remains after the diftillation of nitrous acid reduced to powder, be diffolved in a fufficient quantity of boil- ing water. Let the filtered liquor be evaporated with a very gentle heat, that it may cryftallize. This fait is very feldom prepared on purpofe, as it may be obtained from the refiduum of many other preparations, by fimple folution and cryftallization. For fo ftrong is the affinity between fulphuric acid and potafs, that they fcarcely ever meet without combining to form this fait. All the fulphates except that of ba- ryta are decompofed by potafs and moft ot its combinations \ and reciprocally, all the compounds of potafs are decompofed by ful- phuric acid and moft of its combinations ; and in all thefe decom- pofitions, fulphate of potafs is one of the produas. ' The greateft part of the fulphate of potafs of commerce is ob- tained from the refiduum of the diftillation of fulphate of iron with nitrate of potafs, by lixiviating it, fuperfaturating the folu- tjon with carbonate of potafs, filtering it boiling hot, and allowing it to cryftallize. It is alfo got in confiderable quantities from the refiduum remaining in the retort, after the diftillation of nitrous acid ; and all the colleges have given direaions for obtaining it in this way. This refiduum generally contains an excefs of acid, which converts part of the fulphate into fuper fulphate of potafs. The Dublin College allow this part to be loft. The London drive off the excefs of acid by intenfe heat, and thus get the whole of the fulphate ; but at the fame time convert it into a ve- ry difficultly foluble mafs. While the Edinburgh College, more fcientifically economical than either, derive advantage trom the excefs of acid, by fimply faturating it with carbonate of potafs. As the refiduum of the diftillation of nitrous acid may not al- ways be at hand, the Edinburgh College alfo give a receipt for making this fait, by directly combining its conftituents. It would have been more economical to have ufed a folution of ful- i Chap. III.] Alkaline Salts. 3S9 fihate of iron, in place of fulphuric acid, by which means not on- y art equally pure fuiphate of potafs would have been prbeurea at I fs i xpeuce, but alfo a very pure carbonate of iron. Sulphate of potafs forms fmall tranfparent very hard cryftals, generally aggregated in crufts, and permanent in the air. It h^ a bitter tafte, is flovvly foluble in water, requiring 16 parts at 60- and 4 at 2i20. It is not foluble in alcohol. It decrepitates when thrown on live coals, and melts in a red heat. It confifts of 45.2 acid, and ,54 8 potafs. It is decompofed by the barytic falts ; by the nitrates and muriates of lime and of ftrontia; by the tartrites partially ; arid by the falts of mercury, filver and lead. Sulphate of potafs, in fmall dofes, as a fcruple or half a drachm is an ufeful aperient; in larger ones, as four or five drachms, a mild cathartic, which does not pafs off fo haftily as the fulphate ut foda, and feems to extend its aaion further. SULPHAS POTASS^E CUM SULPHURE; qlim, Sal Polychrestus. Edin. Sulphate of potafs with Sulphur, formerly Sal Polychreft-. Take Nitrate of potafs in powder, Sublimed fulphur, of each equal parts. Mingle them well together, and inje6t the mixture, by little and ' little at a time, into a red hot crucible ; the deflagration bein^ over, let the fait cool, after which it is to be put up in a glafs veffel well flopped. In this procefs the nitric acid of the nitrate of potafs is decom- pofed by the fulphur, which is in part acidified. But the quanti- ty of oxygen contained in the nitric acid, is not fufficient to acid- ify the whole fulphur employed ; therefore part of it remains :n the ftate ot fulphureous acid, which is probably chemically com- bined with part ot the potafs in the ftate of fulphate, for the who!^ faline mafs formed, is more foluble in water than fulphate of pot- afs, is cryTftallizdble, and by expofure to the air, gradually attracls oxygen, and is convened into fulphate of potafs. In its medical effctts and exhibition, it agrees with fulphate of potafs. SULPHURETUM POTASSiE; olim Hepar Sulphuric Edin. Sulphuret of potafs, formerly Liver of Sulphur. Take of Carbonate of potafs. Sublimed Sulphur, each eight ounces. Having ground them well together, put them into a large coated crucible ; and having fitted a coyer to it, and applied live co..^ cautioufly around it, bring them at length to a ftate of fufion. 39© Preparations and Compositions. [Part III. Having broken the crucible as foon as it has grown cold, take out the fuiphuret, and keep it in a well clofed phial. Kali Sulphuratum. Lond. Sulphurated Kali. Take of Flowers of fulphur, one ounce ; Prepared kali, five ounces. With the fulphur melted with a gentle fire, mix the fait by cot}. flant agitation until they unite. Alkali Vegetabile Sulphuratum. Dub. Sulphurated Vegetable Alkali. Take of Cauftic vegetable alkali in powder, Sublimed fulphur, each two ounces. To the fulphur, melted by a gentle heat, add the alkali ; cove*> ing the veffel, if the mixture fhall take fire. There exifts a very ftrong affinity between fulphur and potafs, but they muft be united in a ftate of perfea drynefs ; becaufe, if any moifture be prefent, it is decompofed, and alters the nature of the produa. If potafs be employed as direaed by the Dublin College, it will unite with the fulphur by fimple trituration, and will render one third of its weight of fulphur foluble in water. If carbonate of potafs be ufed as direaed by the other colleges, it is neceffary to bring the fulphur into a ftate of fufion ; it then aas upon the carbonate, aad expels the carbonic acid. It is evident, that to combine with the fame quantity of fulphur, a larger pro- portion of carbonate of potafs than of potafs is neceffary ; but the quantity ordered by the London College is certainly much too large, while that of the Edinburgh College is perhaps too fmall. The Colleges alfo differ in the mode of conduaing the procefs. The London and Dublin Colleges direa the alkaline fait to be projeaed upon the melted fulphur. The fault of this procefs is, that there is a confiderable lofs of fulphur by fublimation, which is avoided, if the fubftances be previoufly intimately mixed, and brought into fufion by a very gradual and cautious application of heat, according to the procefs of the Edinburgh College ; but, if the fufion be not very cautioufly performed, the fudden extrica- tion of fo large a quantity ot carbonic acid gas, is apt to throw the melted matter out of the crucible, and may be attended with unpleafant confequences. If the heat be too great, and the cru- cible uncovered, the fulphureous vapor is apt to inflame, but it is eafily extinguifhed by covering it up. Chap. III.] Alkaline Salts. 394 Sulphuret of potafs, properly prepared, is of a liver brown co- lor, hard, brittle, and has a vitreous fraaure. It has an acrid bitter tafte, and the fmell of fulphur. It is exceedingly prone to decompofition. It is deliquefcent in the air, and is decompofed. It is very fufible, but a ftrong heat feparates the fulphur by fubli- mation. The moment it comes in contaa with water, there is a mutual decompofition. Part of the fulphur becomes acidified, deriving oxygen from the water, and forms fulphate of potafs. Part of the hydrogen of the water decompofed, combines with another portion of the fulphur, and efcapes in the form of fulphu- retted hydrogen gas ; another poition of the hydrogen combines with a third portion ot the fulphur, and remains in folution, unit- ed with the alkali, in the ftate of hydroguretted fuiphuret ot pot- afs. By acids, fuiphuret of potafs is immediately decompofed ; the acid forms a neutral fait with the potafs, and the fulphur is feparated (p. 360.) TARTRIS POTASS^E; olim, Tartarum Solubile. Edin. Tartrite of Potafs, formerly Soluble Tartar. Take of Carbonate of potafs, one pound ; Supertartrite of potafs, three pounds, or as much as may be fufficient; Boiling water, fifteen pounds. To the carbonate of potafs diffolved in the water, gradually add the fuper tartrite of potafs in fine powder, as long as it raifes any effervefcence, which generally ceafes before three times the weight of the carbonate of potafs has been added; then ftrain the cooled liquor through paper, and after due evaporation fet it afide to cryftallize. Kali Tartarisatum. Lond. Tar tar if ed Kali. Take of Prepared kali, one pound ; Cryftals of tartar, three pounds; Diftilled water, boiling, one gallon. To the fait, diffolved in the water, throw in gradually the cryftals ©f tartar powdered ; filter the liquor, when cold, through pa- per ; and, after due evaporation by a gentle heat, fet it apart to cryftallize. Ai.ka.li Vegetabile Tartarisatum. Dub. Tartarifed Vegetable Alkali. Take of Mild vegetable alkali, one pound ; $92 Preparations and Compositions. [Part III, Cryftals of tartar ground into very fine powder, two pounds and i halt ; Boiling water, fifteen pounds. Gradually add the tartar to the vegetable alkali diffolved in the water ; after the liquor has cooled, ftrain it through paper, evap- orate it, and let it cryftallize by cooling flowly. Th e tartarous acid is capable of uniting with potafs in two pro- portions, forming in the one inftance a neutral, and ip the other an acidulous fait. The latter is an abundant p'roduaion of na- ture, but it is eafily converted into the former, by faturating it with potafs, or by depriving it of its excefs of acid. It is by the former method that the colleges direa tartrite of potafs to be prepared, and the procefs is fo fimple, that it requires little com- ment. For the fake of economy, we fhould come as near the point of faturation as poffible ; but any flight deviation from it '■'ill not be attended with rriuch inconvenience. Indeed, it is perhaps advifable to leave a fight excefs of acid, which, forming a fmall quantity of very infolable fait, leaves the remainder per- feaiy neutral. The evaporation muft be conduaed in an earthen veffel, for iron difcolors the fait. It is eafily cryftallized, and the cryftals become moift in the air. It has an unpleafant bitter tafte. It is foluble in four parts of cold water, and ftill more fo- luble in boiling water, and it is alfo foluble in alcohol. It is to- tally or partially decompofed by all acids. On this account it ij i rnproper to join it with tamarinds, or fuch like acid fruits ; which is too often done in the extemporaneous praaice of thofe phyfi- cians who are fond of mixing different cathartics together, and know little of chemiftry. It is alfo* totally decompofed by lime, baryta, ftrontia and magnefia, and partially by the fulphates of potafs, foda and magnefia ; and by the muriate of ammonia. In dofes ofa fcruple, half a drachm, or a drachm, this fait is a mild cooling aperient; too or three drachms commonly loofen the belly • and an ounce proves pretty ftrongly purgative. It has been particularly recommended as a purgative for maniacal and melancholic patients. It is an ufeful addition to the purga- tives of the refinous kind, as it promotes their operation, and at the fame time tends to correa their griping quality. CARBONAS SOD.E; olim, Sal Alkalinus Fixus Fos- silis Purificatus. Edin. Corbonate of Soda, formerly Purified Fixed Fofifil Alkaline Salt* Take of Impure carbonate of foda, any quantity. Chap. IIL] Alkaline Salts. 393 Bruife it ; then boil in water till all the fait be diffolved. Strain the folution through paper, and evaporate it in an iron veffel, fo that after it has cooled, the fait may cryftallize. Natron PrjEparatum. Lond. Prepared Natron. Take ot Barilla, powdered, two pounds ; Diftilled water, one gallon. Boil the barilla in four pints of water for half an hour, and ftrain. Boil the refiduum with the reft of the water, and ftrain. Evap- orate the mixed liquors to two pints, and fet them by for eight' days ; ftrain this liquor again ; and, after due boiling, fet it afide to cryftallize. Diffolve the cryftals in diftilled water ; ftrain the folution, boil, and fet it afide to cryftallize. Alkali Fossile Mite. Dub. Mild Foffil Alkali. Take of Barilla, in powder, ten pounds ; Water, forty pounds. Boil the barilla in the water, in a covered veffel, for two hours^ agitating it from time to time. Evaporate the filtered folution in a wide iron veffel to drynefs, take care that the faline mafs remaining, be not liquefied by too great a degree of heat and agitate it with an iron fpatula, until its color become white. Laftly, diffolve it in boiling water ; evaporate, and let it cryf- tallize by flow refrigeration. If the fait be not pure, repeat the folution and^cryftallization. Thefe direaions are principally intended for the purification of the Spanifh barilla, which is a fufed mafs, confifting indeed prin- cipally of carbonate of foda, but alfo containing charcoal, earths, and other falts. From the two firft caufes of impurity it is eafily feparated by folution and filtration, and the falts may be feparat- ed by taking advantage of their different folubility in cold and in hot water. Frequently the foda does not cryftallize freely, from not being faturated with carbonic acid, which is the reafon why the London College order the folution to be expofed to the at- mofphere for eight days, that it may abforb carbonic acid, be- fore they attempt the'cryftallization of the falts. But the prepara- tion of carbonate ot foda, by the decompofition of fulphate of foda, has now become a manufafcture, and is carried to fuch perfeaion, that its farther purification is almoft unneceffary tor the purpofes ef tbe apothecary. S94 Preparations and Compositions. [Part* III. AQUA SUPER CARBONATIS SOD^. Edin. Water of Super Carbonate of Soda. This is prepared from ten pounds ot water, and two ounces of carbonate of foda, in the fame manner as the water ot fuper- carbonate of potafs (p. 383.) By fuperfaturating foda with carbonic acid, it is rendered more agreeable to the palate, and may be taken in larger quantities, without affeaing the ftomach. PHOSPHAS SOD^. Edin. Phofphate of Soda. Take of Bones burnt to whitenefs, and powdered, ten pounds ; Sulphuric acid, fix pounds ; Water, nine pounds. ,, Mix the powder with the fulphuric acid in an earthen veffel; then add the water, and mix again. Then place the veffel in a va. por bath, and digeft for three days ; atter which dilute the mat's with nine pounds more of boiling water, and ftrain the liquor through a ftrong linen cloth, pouring over it boiling water, in fmall quantities at a time, until the whole acid be wafhed out. Set by the ftrained liquor, that the impurities may fubfide, de- cant the clear folution, and evaporate it to nine pounds. To this liquor, poured from the impurities, add carbonate of foda,, diffolved in warm water, until the effervefcence ceafe. Filter the neutralized liquor, and fet it afide to cryftallize. To the liquor that remains after the cryftals are taken out, add a little carbonate of foda, if neceffary, fo as to faturateexaaiy the phof- phoric acid, and difpofe the liquor by evaporation to form cry ft tals. Laftly, the cryftals are to be kept in a well clofed veflel. The firft part of this procefs cohlifts in deftroying the gelatine of the bones by the aaion of heat. When burnt to perfea white- nefs, they retain their form, but become friable, and confift of phofphate of lime, mixed with a very little carbonate of lime and carbonate of foda. In performing this part of the procefs, we muft take care not to heat the bones to a bright red, as by it they undergo a kind of femi fufion, and give out a phofphoric light.' The complete combuftion of the charcoal is facilitated by the free contaa of the air ; we muft therefore bring every part in fuc- ceffion to the furface, and break the larger pieces. In the fecond part of the procefs, the phofphate of lime is de-, compofed by the fulphuric acid. This decompofition is however only partial. The fulphuric acid combines with part of the lime, and forms infoluble fulphate of lime. The phofphoric acid fepa- Chap, III.] Alkaline Salts. m rated from that portion of lime, immediately combines with the reft of the phofphate of lime, and forms fuper phofphate of lime, which is not farther dccompofeable by fulphuric acid. The fuper phofphate ot lime, thus formed, is foluble in water; but as the fulphate of lime, with which it is mixed, concretes into a very folid mafs, it is in fome meafure defended from the aaioa of water. On this account the whole mafs is direaed to be di- gefted for three days in vapor, by which means it is thoroughly pe- netrated and prepared for folution in the boiling water, which ifc afterwards poured on it. It is probably to render the fubfequen^ folution eaficr, that Thenard direas the bone allies to be made into a thin pafte fbouillie) with water, before the fulphuric acid is added to them. Having thus got a folution of fuper phofphate of lime, it is next decompofed by carbonate of foda, diffolved in water. , This de- compofition, likewife, is only partial, as it deprives the fuper phofphate of lime of its excefs of acid only, and reduces it to the ftate of phofphate. The phofphate of lime, being infoluble, is eafily feparated by filtration, and the phofphate of foda remains in folution. According toThenard, the niceft point in the whole procefs, is the determination of the proper quantity of car- bonate of foda to be added. As the phofphate ot foda does not cryftallize freely unlefs there be a flight excefs of bafe, he'direas that a little more carbonate of foda be added than what is merely fuf- ficient to faturate the excefs of acid in the fuper phofphate of lime, but not to continue the addition,until it ceafe to produce any pre- cipitate. We muft alfo take care not to carry the evaporation of a folution of profphate of foda fo far as to form a pellicle, for it then concretes into an irregular mafs, and does not form beautiful crvftals. After each cryftallization, we muft examine the liquor which remains, and if it be acid, or merely neutral, add to it a lit- tle of the folution of carbonate of foda. In this way Thenard got from 2io» parts of bone afhes, 700 of fulphuric acid, and 667 ot carbonate of foda, 885 of phofphate of foda. According to Four- croy, phofphate of lime confifts of 0.41 acid and 0.59 lime, and fu- per phofphate of lime of 0.54 acid and 0.46 lime; phofphate of lime, treated with fulphuric acid, is only deprived of 0.24 lime, and changed into 0.76 ot fuper phofphate, confiftingof o.,59 phofphate of lime, and 0.17 phofphoric acid, and it is only with this portion of acid that we a,re able to combine foda. Fourcroy is alfo of opi- nion, that profphate of lime requires only 0.4 of its weight of ful- phuric acid to decompofe it, whereas 0.6 arc employed by the Edinburgh College, and others ufe even 0.7 This is not only therefore, a wafte of acid, but renders the produa impure, by being mixed with fulphate of foda, which is fometimes aaually the cafe in the phofphate of foda ot commerce. Befides, as bone- afhes are of very little yalue, it is better that a portion of them B B $96 Preparations and Compositions. [Part III. (hould efcape undecompofed, than that an excefs of acid fhould be added to them. Phofphate of foda cryftallizes in rhomboidal prifms, terminated by three fided pyramids. Its tafte refembles that of common fait. At 6o° it is foluble in four parts of water, and at 212* in two. It efflorefces in the air. By heat it undergoes the watery fufion, and at laft melts into^i white mafs. It confifts, according toThe- nard, of 15 phofphoric acid, 19 foda, and 66 water ot cryftalliza- tion. It is decompofed by moft of the falts having an earthy bafe. Phofphate ot foda was introduced into the practice of phyficby the ingenious Dr. Pearfon of Leicefter Square, London. It pof- feffes the fame medical qualities as fulphate of foda, and the tar- trite of potafs and foda, being an excellent purge in the quantity of an ounce or ten drachms ; and has the peculiar advantage over thefe two falts in being much lefs naufeous than they are. Its tafte is extremely fimilar to that ot common fait; and when given in a bafon of water gruel, or veal broth made without fait, it is fcarcely perceptible by the palate, and confequently is well adapt- ed for patients whofe ftomachs are delicate, and who have an an- tipathy againft the other falts. The only objeaion to its general ufe is the very great difference between its price and that of ful- phate of foda, a difference which might certainly be diminilhed. MURIAS SOD.E EXSICCATUS. Edin. Sal Communis Exsiccatus. Dub. Dried Common Salt. Take of Common fait, any quantity. { Roaft it over the fire in a wide iron veffel, until it ceafe to decrep- itate, agitating it from time to time. By this procefs the muriate of foda is reduced into the ftate in which it is employed for the diftillation of muriatic acid. It not only deprives it entirely of its water of cryftallization, which, from being variable in quantity, would otherwife render the acid obtained unequal in ftrength, but alfo deftroys fome coloring mat- ter it contains ; for if we prepare muriatic acid from cryftallized muriate of foda, we obtain a colored muriatic acid, while the dri- ed muriate furnifhes a perfeaiy colorlefs one. SULPHAS SOD^E ; olim, Sal Glauberi. Edin. Sulphate of Soda ; formerly, Glauber's Salt. Diffolve the acidulous fait which remains after the diftillation ol muriatic acid, in water ; and having mixed chalk with it to re- Chap. III.] Alkaline Salts. 397 move the fuperfluous acid, fet it afide until the fediment fub- fides, then evaporate the liquor decanted from them, and ftrain through paper, fo that it may cryftallize. Natron VitriolatuM; Lond. Vitriolated Natron. Take of The fait which remains after the diftillation of the muriatic acid, two pounds ; « Diftilled water, two pints an.d an half. Burn out the fuperfluous acid with a ftrong fire, in an open vef- fel ; then boil it for a little time in the water ; ftrain tbe folu- tion, and fet it by to cryftallize. Alkali Fossile Vitriolatum; Dub. Vitriolated Foffil Alkali. Diffolve the fait, which remains atter the diftillation of muriatic acid, reduced to powder, in a fufficient quantity of boiling wa- ter. Evaporate the filtered folution, and cryftallize the fait by flow refrigeration. The obfervations we made refpeaing the different methods fol- lowed by the Colleges, for extracting fulphate of potafs from the refiduum of the diftillation of nitrous acid, apply in the prefent inftance, except that the Edinburgh College do not preferve the fuperabundant acid when prefent, by faturating it with carbonate of foda, but get rid of it by faturating it with carbonate of lime, with which it forms an infoluble fulphate of lime. In faa, the price of fulphate of foda is fo very fmall, that it would be no econ- omy to ufe carbonate of foda to faturate the fuperabundant acid. By far the greateft part of the fulphate of foda is obtained from manufaaurers, as a refult of procefles performed for the fake of other fubftances, as in the preparation of muriate of ammoniaj oxygenized muriatic acid, &c. Sulphate of foda cryftallizes in fix fided prifms, terminated by dihedral fummits. The cryftals are often irregular, and their fides are ufually channelled. Their tafte is at firft fait, and after- wards difagreeably bitter. They are foluble in 2.67 parts of wa- ter at 6o*, and in 0.8 at 2120. In the air they efflorefce. They undergo the watery fufion, and in a red heat melt. They confift of 23.52 fulphuric acid, 18.48 foda, and 58 water; when dried at 7000, of 56 acid and 44 foda. It is decompofed by baryta and potafs, and falts containing thefe bafes, and by tbe falts ot filver, mercury and lead. Taken from half an ounce to an ounce, or more, it proves a mild and ufeful purgative; and in fmaller dofes, largely diluted, £3T * 398 Preparations and Compositions. [Part III. a ferviceable aperient and diuretic. It is commonly given in fo- lution, but it may alfo be given in powder, after it has eftlorefced. In this form the dofe muft be reduced to one half. TARTRIS POTASStEet SODjE; olim Sal Rupellensis. Edin. Tartrite of Potafs and Soda, formerly Rochelle Salt. It is prepared from the carbonate of foda and fupertartrite of pot- afs, in the fame manner as the tartrite of potafs. r Natron Tartarisatum. Lond. Sal Rupellensis. Dub, Tartarifed Natron. Rochelle Salt. Take of Natron, twenty ounces ; Cryftals of tartar, powdered, two pounds ; Diftilled water, boiling, ten pints. Diffolve the natron in the water, and gradually add the cryftals of tartar ; filter the liquor through paper ; evaporate, and fet it afide to cryftallize. The. tartarous acid in feveral inftances is capable of entering into combination at the fame time with two bafes. In the prefent example, the fuperabundant acid of the fupertartrite of potafs is neutralized with foda, and in place of a mixture of tartrite of pot- afs and tartrite of foda, each poffefling their own properties, there refults a triple fait, having peculiar properties. The tartrite of potafs and foda forms large and very regular cryftals, in the form of prifms with eight fides nearly equal, which are often divided longitudinally, almoft through their axis. It has a bitter tafte. It is foluble in about five parts of water, and ifflorefces in the air. It is decompofed by the ftrong acids, which combine with the foda, and feparate fupertartrite of potafs, and by baryta and lime. By heat its acid is deftroyed. It confifts of 54 tartrite of potafs, and 46 tartrite of foda. It was introduced into medical praaice by M. Seignette, an apothecary at Rochelle, whofe name it long bore. It is ftill fre- quently employed ; and though lefs agreeable than the phofphate of foda, it is much more fo than the fulphate of foda. It is lefs purgative than thefe, and muft be given in larger dofes. AQUA AMMONITE; olim, Aqua Ammonia Caustics. Edin. Water of Ammonia, formerly Water of Cauflic Ammonia. Take of Muriate of ammonia, fixteen ounces ; Quicklime, frefh burnt, two pounds ; Water, fix pounds. s Chap. III.] Alkaline Salts, 399 Having put one pound of the water into an iron or ftone ware vef- fel, add the quicklime, previoufly beat, and cover the veffel for twenty four hours, until the lime fall into a powder, which is to be put into a retort. Add to it the muriate of ammonia, diffolved in five pounds of water; and fhutting the mouth of the retort, mix them together by agitation. Laflly, diftil into a refrigerated receiver with a very gentle heat (fo that the op- erator's hand can eafily bear the heat of the retort,) till twenty ounces of liquor are drawn off. In this diftillation the veffels are to be fo luted as to confine effectually the vapors which are very penetrating. Aqua Ammonia Pur£, Lond. Water of Pure Ammonia, Take of Sal ammoniac one pound ; Quicklime, two pounds ; Water, one gallon. Add to the lime two pints of the water. Let them ftand together an hour ; then add the fal ammoniac and the other fix pints of water boiling, and immediately cover the veffel. Pour out the liquor when cold, and diftil off with a flow fire one pound. Liquor Alkali Volatilis Caustici. Dub. Liquor of Cauftic Volatile Alkali. Fake of Sal ammoniac, fixteen ounces ; Lime, frefh burnt, two pounds ; Water, fix pouuds. Sprinkle one pound ot boiling water upon the lime, placed in a itoneware veffel, and cover up the veffel. Twenty four hours afterwards, mix the fait with the lime, which will have crum- bled to powder, taking care to avoid the vapors. Then put the mixture into a retort, and pour upon it five pounds ot wa- ter. Having previoufly agitated them, draw off with a moder- ate heat twenty ounces of liquor into a refrigerated receiver, having luted carefully the joining of the veffels. The fpecific gravity of this liquor is to that of diftilled water, as 936 to 1000. In this procefs the muriate of ammonia is decompofed by the lime, in confequence of its having a ftronger affinity for muriatic acid than ammonia has. It is abfolutely neceffary that the lime employed be very recently burnt, as the prefence ot carbonic acid would render the ammonia partially carbonated. This accider.: 03*3 400 Preparations and Compositions. [Part. III. is alfo prevented by the great excefs of lime ufed, which having a greater affinity for carbonic acid than ammonia has, retains any fmall quantity of it which may be accidentally prefent. The lime is alfo to be flaked before it be added to the muriate of ammonia, becaufe the heat produced during its flaking would caufe a violent difengagement of ammonia gas, and be attended with great lofs. The addition ot the water is effential to the exiftence of the ammo- nia in a liquid form, for in itfelf it is a permanently elaftic fluid. A much greater quantity of water, however, is ufed than what is fufficient to abforb all the ammonia ; the reft is intendedto render the decompofition flower and more manageable, and to keep the muriate of lime which remains in the retort in folution ; for oth- erwife it would concrete into a folid mafs, adhering ftrongly to the bottom of the retort, very difficult to be wafhed out, and often en- dangering its breaking. As foon as the flaked lime and muriate of ammonia are mixed, they fhould be put into the retort, the water poured upon them, and the diftillation begun ; for, by the London procefs, of adding the water boiling hot to the mixture, and letting it ftand to cool before it is introduced into the retort, there is a very great lofs of ammonia, and for no reafon whatever. A very fmall degree of heat is fufficient for the diftillation, and the whole ammonia rifes with the firft portion of water, or even before it. It is therefore neceffary that the veffels be very clofely luted to each other, to prevent it from efcaping. But this renders the ut- moft care neceffary in the diftillation ; for too fudden, or too great a heat, from the rapid difengagement of gas, or even the expanfion of the air contained in the veffels, would endanger their burfting. Many variations of greater or lefs importance have been made in conduaing this procefs, but the moft confiderable is that o( Gottling. The peculiarity of his method confifh in difengaging the ammonia in the form of gas, and combining it afterwards with water with the affiftance of preffure. He ufes an earthen ware cucurbit, with a tubulated capital. To the fpout of the capital, one end of a bent glafs tube is accurately luted, while the other end is introduced to the bottom of a tall narrow mouthed glafs phial, containing the requifite quantity of water. Into the cucur- bit he puts two parts of finely powdered lime, and one of muriate of ammonia, and then applies the heat. He does not fhut the UN bulature until the fmell of ammonia becomes manifeft, and opens it again as foon as the procefs is finifhed, and before the veffels begin to cool, as other-wife the folution ot ammonia would flow back into the cucurbit, and fpoil the whole operation. But this management of the tubulature requires very great attention, and, therefore, we think that this apparatus would be very much im- prove^, by fubftituting for the tubulature one of Welter's tube* Chap. III.] Alkaline Salts. 401 of fafety, by which even the poffibility of fuch an accident is pre- cluded. We have already (131.) mentioned the properties of ammo- nia in its gafeous form, and its relation to the alkalies (105.) When combined with water, it imparts to it many of thefe prop* erties, and leffens its fpecific gravity. Liquid ammonia, or wa- ter faturated with ammonia, contains 74.63 water, and 25.37 am- monia ; and its fpecific gravity is 0.9054. When it has the fpe- cific gravity mentioned by the Dublin College 0.936, it contains about 83 of water, and 17 of ammonia. It affumes its elaftic form, and feparates from the water, when heated to about 1300, and quickly attraas carbonic acid from the atmofphere. It de- compofes many of the earthy and all the metalline falts, and is capable of diffolving or combining with many of the metalline oxides, and even of oxidizing fome of the metals. When pure, water of ammonia does not effervefce with any of the acids, or form a precipitate with alcohol. Water of ammonia is very rarely given internally, although it maybe ufed in dofes of ten to twenty drops, largely diluted, as a powerful ftimulant in afphyxia, and fimilar difeafes. External- ly it is applied to the fkin as a rubefacient, and in the form of gas to the noftrils and to the eyes ss a ftimulant ; in cafes of torpor, paralyfis, rheumatifm, fyncope, hyfteria, and chronic ophthalmia. ALCOHOL AMMONIATUM, sive SPIRITUS AM. MONl^E. Edin. Ammoniated Alcohol, or Spirit of Ammonia. Take of Diluted alcohol, four pounds ; Muriate of ammonia four ounces ; Carbonate of potafs, fix ounces. Mix them, and draw off by diftillation, with a gentle heat, two pounds. Spiritus Ammonite. Lond. Spirit of Ammonia. Spiritus Alkali Volatilis. Dub. Spirit of Volatile Alkali. Take of Proof fpirit, three pints ; Sal ammoniac, four ounces ; Potafhes, fix ounces. Mix, and diftil with a flow fire, one pint and an half. When muriate of ammonia is decompofed by carbonate of potafs, the produft is a mixture of carbonate of ammonia with a 402 Preparations and Compositions. [\\wi. III. variable quantity of ammonia; for the carbonate of potafs is never faturated with carbonic acid. Again, as diluted alcohol is em- ployed in this procefs, and one half only is drawn off, it is evident that there is either a want of economy, or the whole alcohol comes over before any of the water. But if the latter fuppofition be true, there is alfo a want of economy, for the alcohol will diffolve only the ammonia, and leave the whole carbonate undiffolved. The faa is, that when we perform the procefs as directed by the Colleges, a very large proportion of carbonate of ammonia fub- limes, which remains undiffolved in the diftilled liquor ; but as this liquor (after the particles of carbonate ot ammonia, which were diffufed through it have feparated in the form of very regu- lar cryftals, adhering to the fides of the veffel) effervefces with acids, the diftilled liquor cannot be pure alcohol, but muft contain a proportion of water capable of diffolving fome carbonate of am- monia. From both confederations, it appears to us, that the pro- cefs direaed, it not unchemical, is at leaft uneconomical. It is remarkable that the Edinburgh College, for what reafon we know not, fhould have adopted, in the two laft editions of their Pharmacopoeia, this procefs from the London College, and rehnquifhed one which to us appears unexceptionable, as it is not attended with the fmalleft lofs, either of alcohol or ammonia, and gives both a more aaive and a more uniform preparation. A flrong proof of its fuperiority is, that the apothecaries ftill conti- nue to follow it, although it has been rejeaed by the College, We fhall therefore infert it here without any alteration, except of the nomenclature. Take of Quicklime, fixteen ounces ; Muriate of ammonia, eight ounces ; Alcohol, thirtytwo ounces. Having bruifed and mixed the quicklime and muriate of ammo- nia, put them into a glafs retort; then add the alcohol, and dif- til to drynefs, in the manner direaed for the water of ammo- nia. CARBONAS AMMONITE ; olim, Ammonia Pr^parat/v, Edin. Carbonate of Ammonia, formerly Prepared Ammonia. Take of Muriate of ammonia, one pound ; Pure carbonate of lime (commonly called chalk) dried, n.a pounds. Having triturated them feparately, mix them thoroughly* and -4- blime from a retort into a refrigerated receiver. i Chap. III.] Alkaline Salts. 4f3 Ammonia Pr'.hparata. Lond. Prepared Ammonia. Take of Sal ammoniac, powdered, one pound ; Prepared chalk, two pounds. Mix and fublime. Alkali Volatile Mite Dub. Mild Volatile Alkali. Take of Sal ammoniac, in powder, one pound ; Prepared chalk, two pounds. Dry them with the greateft caie ; and having mixed them, intro- duce them into a retort. By means of heat fublime the alka- Jine fait, which is to be received in a proper veffel. In this procefs the two fubftances employed undergo a mutual decompofition, the muriatic acid combining with the lime, and the carbonic acid with the ammonia. The proportion of carbonate of lime direaed, is perhaps more than fufficient to decompofe the muriate of ammonia ; but it is the fafe fide to err on ; for it is only fometimes inconvenient, from obliging us to make ufe of larger veffels, whereas, if any portion of the muriate ot ammonia were to remain undecompofed, it would fublime along with the carbonate, and render the produa impure. Gottling ufes three parts of chalk to two of muriate of ammonia, but he dries his chalk before he weighs it. The chalk is always to be very tho- roughly dried before it is ufed in this preparation, as the prefence ot moifture injures the produa. The ingredients are to be tho- roughly mj^ed by trituratioo, before they are introduced into the retort, that no part of the muriate of ammonia may efcape de- compofition ; and we are even fometimes direaed 10 cover the furface of the mixture, after they are in the retort, with powder- ed chalk. This however, is uniieceflary. Carbqnate of lime does not aa on muriate ot ammonia till a confiderable heat be ap- plied. Gottling fays, that the fublimation muft be conduaed in the open fire, and therefore ufes an earthern ware cucurbit, with a tubulated capital. When a glafs reiore is employed, it fhould have a very wide neck ; and the beft form for the receiver is cylindrical, as it enables us to get out the carbonate of ammonij condenfed in it without breaking it. The refiduum which re- mains in the retort, furnifhes muriate of lime by lixiviation and evaporation. Sometimes carbonate of potafs is employed for the preparation of carbonate of ammonia. The theory of the procefs is the fame and the decompofition is effeaed at a lower temperature. But as 404 Preparations and Compositions. [Part III. potafs is very rarely faturated with carbonic acid, part of the am- monia is evolved in the form of gas, which, if not permitted to efcape, will burft the veffels. To prevent this lofs, therefore, Mr. Gentling ufes a cucurbit and capital, furnifhed with a bent tube, which is to be immerfed in a phial of water; by which con- trivance, while the carbonate of ammonia is condenfed in the capital, the gafeous ammonia is abforbed by the water. When potafs is ufed, the refiduum contains muriate of potafs. Carbonate of ammonia is obtained in the form of a white cryf- tallized mafs, of a fibrous texture, having the fmell and tafle of ammonia, but weaker. It is foluble in twice its weight ot cold water, and is more foluble as the temperature of the water in- creafes ; but when it approaches to a boiling heat, the carbonate is volatilized. It is infoluble in alcohol. It is permanent in the air, and is not decompofed, but is eafily vaporized by heat. It is faid to vary very much in its compofition, and to contain more ammonia, and lefs acid and water, in proportion to the high tem- perature employed in preparing it, the quantity of alkali varying from 50 to 20 per cent. It is decompofed by moft of the acids, and all the alkaline and fome of the earthy bafes ; by the earthy fulphates except thofe of baryta and ftrontia ; by the earthy ful- phates, muriates and fluates ; by the nitrates of baryta, and fuper- phofphate of lime. Carbonate of ammonia exaaiy refembles ammonia in its ac tion on the living body ; but is weaker, and is principally ufed as fmelling falts in fyncope and hyfteria. AQUA CARBONATIS AMMONITE ; olim, Aqua Am- MONI.E. Edin. Water of Carbonate of Ammonia, formerly Water of Ammonia, Take of Muriate of ammonia, Carbonate of potafs, each fixteen ounces; Water, two pounds. Having mixed the faks and put them into a glafs retort, pour the water upon them, and diftil to drynefs in a fand bath, gradual- N ly increafing the heat. Aqua Ammonite. Lond. Water of Ammonia. Take of Sal ammoniac, one pound : Potafhes, one pound and a half ; Water four pints. Draw off two pints by diftillation, with a flow fire. Chap. III.] Alkaline Salts. 405 Liquor Alkali Volatilis Mitis. Dub. Liquor of Mild volatile Alkali. Take of Mild vegetable alkali, Muriate of ammonia, each fixteen ounces ; Water, two pounds. Draw off the liquor by diftillation until the refiduum become dry. The fpecific gravity of this liquor is to that of diftilled water as 1110 to iodo. The produa of this procefs is a folution of carbonate of am- monia, while the refiduum in the retort is muriate ot potafs. In this inftance, the decompofition of the muriate of ammonia can- not be effeaed by carbonate of lime, becaufe the addition of the water prevents the application of the neceffary heat, whereas car- bonate of potafs aas at a moderate temperature. The direaions ot the London College differ from thofe of the other Colleges in two particulars ; in the quantity of water, added, and in the pro- portion of carbonate of potafs employed. The addition of more water than what is to be drawn off by diftillation, muft increafe the fize of the apparatus employed, an inconvenience alwa)s to be avoided, if poffible. With regard to the quantity of carbonate of potafs employed, from calculation, and the authority of the beft writers, for we do not fpeak from experience, we are difpofed to think the London College in the right : For the 42.75 parts of muriatic acid in 100 parts of muriate of ammonia, require 84.12 of potafs to faturate them ; but in 100 parts of carbonate of pot- afs there are not above 50 parts of potafs, fo that carbonate of pot- afs is not capable of decompofing an equal weight of muriate ot ammonia. LIQUOR VOLATILIS, SAL et OLEUM CORNU CER- VI. Lond. The volatile Liquor, Salt, and oil of Hartfhorn. Take of Hartfhorn, ten pounds. Diftil with a fire gradually increafed. A volatile liquor, fait, and oil will afcend. The oil and fait being feparated, diftil the liquor three times. To the fait add an equal weight of prepared chalk, and fublime thrice, or till it become white. The fame volatile liquor, fait, and oil, may be obtained from any animal fubftance except fat. 406 Preparations and Compositions. [Pc.rt III. Liouor Volatilis Cornu Cervini. Dub. Volatile Liquor of Hartfhorn. Take of Hartshorn, any quantitv. Put it into a retort, and diftil with a gradually increafed heat, the volatile liquor, fait, and oil. Then repeat the diftillation of the volatile liquor until it become as limpid as water, feparat- ing by filtration tha oil and fait after each diftillation. The fpecific gravity of this liquor is to that of diftilled water as 1 no to 1000. If hartshorn cannot be had, the bones of any other animal may be fubftituted for them. The wholefaledealers have very large pots for this diftillation, with earthen heads, almoft like thofe of the common ftill ; for re- ceivers, they ufe a couple of oil jars, the mouths of which are lu- ted together ; the pipe that comes from the head, is conneaed by means of an adopter with the lower jar, which is alfo furnifhed With a cock for drawing off the fluids condenfed in it. The up- per jar is entire, and in it is condenfedthe folid carbonate of am- monia. When a large quantity of the fubjea is to be diftilled,it is cuftomary to continue the operation for feveral days fucceffive- ly ; only unluting the head occafionally, to put in frefh materials. When the upper jar becomes entirely filled with carbonate of ammonia, it cracks. It is then to be removed, the fait to be ta- ken out of it, and a frefh one fubftituted in its place. When only a fmall quantity of fpirit or fait is wanted, a com- mon iron pot, fuch as is ufually fixed in fand furnaces, may be employed ; an iron head being fitted to it. The receiver ought to be large, and a glafs, or rather tin, adopter inferted between it and the pipeot the head. The diftilling veffel being charged with pieces of horn, a mo- derate fire is applied, which is flowly increafed, and raifed at length almoft to the utmoft degree. At firft water arifes, which gradually acquires color and fmell, from the admixture of em- pyreumatic oil and ammoniacal falls ; carbonate of ammonia next arifes, which at firft diffolves, as it comes over, in the water, and thus forms what is called {he fpirit. When the water is faturat- ed, the remainder of the fait concretes in a folid form to the fides of the recipient. If it be required to have the whole of the fait folid, and undiffolved, the water fhould be removed as foon as the fait begins to arife, which may be known by the appearance of white fumes ; and that this may be done the more commodioufly, the receiver fhould be left unluted, till this firft part of the procefs be finifhed. The white vapors which now arife, fometimes come over with fuch vehemence as to throw off orburft the receiver ; to prevent this accident, it is convenient to have a fmall hole in the Chap. III.] Alkaline Salts. 407 luang, which may be occafionally flopped with a wooden peg, or opened, as the operator fnall find proper. Laftly, the oil arifes, which acquires greater color and confiftency as the operation ad- vances, Carbonate of ammonia ftill comes over, but it is partly diffolved in the hot oily vapor. At the fame time, there is a confiderable difengagement of gas, confi fling ofa mixture of car- buretted hydrogen, often containing fulphur aiad phofphorus, and of carbonic acid. All the liquid matters being poured out of the receiver, the fait which remains, adhering to its fides, is to be wafhed out with a little water, and added to the reft. It is convenient to let the whole ftand for a few hours, that the oil may the better difengage itfelf from the liquor, fo as to be firft feparated by a funnel, and afterwards more perfeaiy by filtration through wet paper. None of thefe produas, except perhaps a fmall quantity of the water, exift ready formed in the matter fubjeaed to the diftilla- tion, but are produced by a new arrangement ot its conftituents. For the produfclion of ammonia, it is abfolutely neceffary that it contain nitrogen, or be what we have called a quaternary oxide. Although fome vegetable, and moft animal fubflances, are of this kind, yet only the moft folid parts of animals, fuch as bone and horn, are employed for the produaion of ammonia ; becaufe they furnifh it lefs mixed with other fubftances, are eafily obtained, and at little expenfe, and are very manageable in the diftillation. On the application of heal, as foon as all the water which they contained is expelled, their elements begin to aa on each other, and to form binary, or at moft ternary compounds. Water is formed of part of the oxygen and hydrogen, ammonia of nitrogen and hydrogen, carbonic acid of carbon and oxygen, then oil of hydrogen and charcoal, while the fuperfluous carbon remains in the retort in the ftateof charcoal. As the formation of thefe fub- ftances is fimultaneous, or in immediate fucceffion, they are not obtained feparately, but are mixed with each other. The water is faturated with carbonate of ammonia, and impregnated with em- pyreumatic oil, while the carbonate of ammonia is difcolored with oil ; and the oil contains carbonate of ammonia diffolved in it. They may, however, be feparated from each other in a great Kieafure, in the manner already defcribed, But a fmall portion of oil obftinately adheres both to the falts and its folution, which conftitutes the onlv difference between fait and fpirit of harts- horn, as they are called, and the purer carbonate of ammonia, as obtained by the decompofition of muriate of ammonia. 408 Preparations and Compositions. [Part III. AQUA ACET1TIS AMMONITE; vulgo, Spiritus Min- dereri. Edin. Water of Acetite of Ammonia, commonly called Spirit of Minde- rerus. Take of Carbonate of ammonia in powder, any quantity. Pour upon it as much diftilled acetous acid as may be fufficient to faturate the ammonia exaaiy. Aqua Ammonia, Acetate. Lond. Water of Acetated Ammonia. Take of Ammonia, two ounces ; Diftilled vinegar four pints, or what may be fufficient to fatu- rate the ammonia. Mix them. Liquor Alkali Volatilis Acetati. Dub. Liquor of Acetated Volatile Alkali. Take of Mild volatile alkali, two ounces ; Diftilled vinegar, three pounds and a half, or as much as may be fufficient to faturate the volatile alkali. Mix them gradually by agitating them well together. By this procefs we obtain acetite of ammonia diffolved in the water of the acetous acid ; but as this is apt to vary in quantity, the folution alfo varies in ftrength, and the cryftallization ot the' fait is attended with too much difficulty to be praaifed for phar- maceutical purpofes. Its cryftals are long, flender and flatted, of a pearly white color, and of a cool fweetifh tafte, are very deli- quefcent, melt at 1700, and fublime at 2500. It is decompofed by the acids, alkalies, and feveral of the earths, and metalline falts ; and when in folution, its acid is decompofed fpontaneoufly, and by heat. Different propofals have been made to get a folution of greater ftrength and uniformity, than that ftill retained by the Britifh Colleges. Mr. Lowe faturates four ounces of carbonate of potafs with diftilled vinegar, and evaporates the folution to 36 ounces. He then mixes it with two ounces of muriate of ammonia, and diftils the mixture in a glafs retort. Acetite of ammonia comes o- ver. The laft edition of the Pruflian Pharmacopoeia prepares it by faturating three ounces ot carbonate of ammonia with a ftrong acetous acid (obtained by diftillation from acetite of foda, dif- folved in two parts of water, and decompofed by fulphuric acid) and diluting the folution with water, fo that it fhall weigh twen- Chap. III.] Alkaline Salts. 469 ty four ounces. One ounce, therefore, contains the alkali of a drachm of carbonate of ammonia. Acetite of ammonia, when affifted by a warm regimen, proves an excellent and powertul fudorific ; and as it operates without quickening the circulation or increafing the heat of the body, it is admiffible in febrile and inflammatory difeafes, in which the ufe of ftimulating fudorifics are attended with danger. Its aaion may likewife be determined to the kidneys, by walking about in a cool air. The common dofe is half an ounce, either by itfelf, or along with other medicines adapted to the fame intention. HYDRO SULPHURETUM AMMONITE. Edin. Hydro Sulphur et of Ammonia. Take of * Water of ammonia, four ounces ; Subjea it in a chemical apparatus to a ftream of the gas, which arifes from Sulphuret of iron, four ounces. Muriatic acid, eight ounces, previoufly diluted with two pounds and a half of water. Sulphuret of Iron is conveniently prepared for this pur- pofe, from Purified filings of iron, three parts ; Sublimed fulphur, one part. Mixed and expofed to a moderate degree of heat in a covered cru- cible, until they unite into a mafs. Sulphuretted hydrogen is capable of combining with dif- ferent bafes in the manner of an acid. In the prefent preparation, it is combined with ammonia. It is obtained by decompofing fu'- phuret of iron with muriatic acid. As foon as the acid, by its fuperior affinity, feparates the iron from the fulphur, the latter immediately reaas on the water, the oxygen of which forms with one portion of it fulphuric acid, while the hydrogen diffolves an- other portion, and forms fulphuretted hydrogen gas. The com- bination of this with ammonia is facilitated by reduaion of tem- perature, and by making it pafs through a column of the water of ammonia by means of an apparatus, fuch as Woulfe's or Nooth's. Trommfdorff has propofed, that the fulphuretted hydrogen gas fhould be obtained by the decompofition of fuiphuret of potafs ; but in this wgy its formation is too rapid to be eafily managed. Gottling fays, that the acid fhould be added gradually, and that the whole muft be conftantly agitated. But thefe precautions are rendered unneceffary, by diluting the acid in the degree.direaed by the pharmacopoeia. Mr. Cruickfhank, who firft fuggefted tie ufe of hydro fuiphuret of ammonia in medicine, direas the ful_ phuret of iron to be prepared by heating a bar of iron to a whitc 410 Preparations and Compositions. [Part III. heat in a fmith's forge, and rubbing againft the end of it a roll of fulphur. The iron at this temperature immediately combines with the fulphur, and forms globules of fulphuretted iron, which fhould be received in a veffel filled with water. It is, however, more conveniently obtained in the manner direaed by the Col- lege. Iron is capable of combining with two proportions of ful- phur. At a high temperature it combines with 60 per cent, and has a dull blackifh color. In this ftate it is fit for the produc- tion of fulphuretted hydrogen gas. At a lower temperature it takes up 90 per cent, of fulphur, acquires a greenifh yellow co- lor, and in every refpecf refembles native pyrites. This cannot be decompofed by acids, and is therefore unfit for the produaion of gas ; but it may be reduced to the ftate ot iron fulphuretted to the minimum, by expofing it to a fufficiently high temperature, or by melting it with half its weight of iron filings. It was pro. bably from not attending to the different ftates of fulphuretted iron, that fome of the German chemifts failed in their attempts to procure from it fulphuretted hydrogen gas, and had recourfe to fuiphuret of potafs. Hydro fuiphuret of ammonia, or more correaiy Sulphuretted hydroguret of ammonia, aas powerfully on the living fyftem. It induces vertigo, drowfinefs, naufea and vomiting, «$nd leffens the aaion of the heart and arteries. It therefore feems to be a direa fedative. According to the doarine of the chemical phy- fiologifts, it is a powerful difoxygenizing remedy. It has only been ufed in diabetes by Dr. Rollo and others, under the name of Hepatized Ammonia, in dofes of five or ten drops twice or thrice a day. SJ=«s=- CHAP. IV. m EARTHS, AND EARTHT SALTS. ■ MURIAS BARYTA. Edin. <- Muriate of Baryta. Take of Sulphate of baryta, two pounds ; Charcoal of wood in powder, four ounces. Roafl the fulphate with fire, that it may be more eafily reduced to a very fine powder, with which the charcoal is to be inti- Chap. IV.] Earths, and Earthy Salts. • 411 mately mixed. Put the mixture into a crucible, and having fitted it with a cover, heat it with a ftrong fire for fix hours. Then triturate the matter well, and throw it into fix pounds of water in an earthen or glafs veffel, and mix them by agitation, preventing as much as poffible the aaion of the air. Let the veffel ftand in a vapor bath until the part not diffolved fhall fubfide, then pour off the liqour. On the undiffolved part pour four pounds more of boiling water, which, after agitation and depofition, are to be added to the former liquor. Into the liquor while ftill warm, or, if it fhall have cooled, again heated, drop muriatic acid as long as it excites any effervefcence. Then ftrain it and evaporate it fo as to cryftallize. In the materia medica of the Edinburgh College, the carbonate of baryta is introduced', for the purpofe of forming the muriate ; but as that mineral is not very common, and fometimes not to be procured, it became neceffary to defcribe the manner of preparing the muriate from the fulphate. This is, however, attended with very confiderable difficulties, on account of the very ftrong attrac- tion which fubfifts between the fulphuric acid and baryta. The fulphate of baryta may be decompofed, 1. By compound affinity ; by means of carbonate of potafs. 2. By decompofing its acid ; by means of charcoal. Carbonate of potafs is capable of effeaing this decompofition, either in the dry or humid way. Klaproth boils 16 ounces of finely powdered fulphate of baryta with 32 ounces of purified car- bonate of potafs, and five pounds of water, for an hour in a tin kettle, conftantly agitating the mixture, and renewing the water as it evaporates. He then allows it to fettle, pours off the fluid, which is a folution of fulphate of potafs, and edulcorates the pre- cipitate with plenty of water. He next diffolves the carbonate of baryta, which it contains, in muriatic acid. The portion of fulphate which is not decompofed, may be treated again in the fame manner. On the other hand, Van Mons mixes equal parts of fulphate of baryta and carbonate of potafs with one fourth of their weight of charcoal all in powder, and heats the mixture to rednefs in a cru- cible. When it cools he wafhes out the fulphate and fuiphuret of potafs with water, then boils the refiduum with a little potafs, and wafhes it again. The carbonate of baryta thus obtained, he dif- folves in muriatic acid. But by thefe methods of decompofing the fulphate of baryta, we do not get rid of the metallic fubftances which it often con- tains, and which often render the muriate thus prepared unfit for medical ufe. But the metalline muriates roay be expelled ac- cording to Weftrumb, by heating the fait to rednefs as long as any fumes arife. The pure muriate of baryta is then to be diffolved 412 Preparations and Compositions. [Part 1IL in water and cryftallized. Gottling, with the fame intention of getting rid of metalline fubftances, choofes fulphate of baryty, perfeaiy colorlefs, and treats it with muriatic or nitromuriatic acid before he proceeds to decompofe it. The acid of the fulphate of baryta is decompofed at a very high temperature by charcoal; At fuch a temperature charcoal has a greater affinity for oxygen than fulphur has ; it therefore decom- pofes fulphuric acid, by depriving it of its oxygen, and flies off in the ftate of carbortic oxide or acid gas, while the fulphur com- bines with the baryta. On adding Water to the fuiphuret thus formed, new combinations take place. A portion of fulphate of baryta is regenerated, while hydroguretted fuiphuret and fulphu- retted hydroguret of baryta remain in folution. This folution is exceedingly prone to decompofition, and muft therefore be pre- ferved from the aaion of the air as much as poffible. It alfo Cryftallizes by cooling, and therefore fhould be kept at a boiling heat. On the addition of muriatic acid, there is a violent effer- vefcence and difengagement of fulphuretted hydrogen gas, while very pure muriate ot baryta remains in folution. When prepared in this way, it cannot be contaminated with any of the noxioui metals, as their compounds with fulphur and hydrogen are not fo- luble. On this account, therefore, it is the procefs adopted by the Edinburgh College. Muriate of baryta commonly cryftallizes in tables. It has a dif- agreeable bitter tafte; is foluble in five parts of water at 6o°, and in iefs boiling water. It is fcarcely foluble in alcohol; and its fo- lution burns with a yellow flame. It cryftallizes by evaporation ; its cryftals are permaient; and by the aaion of heat decrepitate, dry and melt. When cryftallized it contains 20 acid, 64 baryta^ and 16 water ; when dried, 23.8 acid, and 76. 2 baryta. It is rlecoMpofe'.. by the fulphates, nitrates, and fulphites ; and by the a! valine phofphates, borates and carbonates. When pure it has no ( Aor ; does not deliquefce ; does not burn with a red or pur- ple fl *me "Then diffolved ir. alcohol ; and is not precipitated by gaiuc ac;c, prufliate of potafs and iron, or hydro fuiphuret of amm >nia. It is commonly given in folution. SOLUTIO MUPIATIS BARYTiE. Edin. Solution of Muriate of Baryta. Take of Muriate of baryta, one part j Diftilled water, three parts. Diffolve. _ The proportion of water direaed here for the folution of mil* tiate of baryta, is confiderably lefs than what is ftated to be ne- Chap. IV.] Earths, and Earthy Salts. 412 ceffary by the writers on chemiftry. It is however fufficient, even at the loweft ordinary temperatures, a circumftance which fhould be attended to in making faturated folutions of faline bod* ies. Muriate of baryta is generally faid by writers on the materia rnedica to be a fiimulant deobftruent; and yet Hufeland, one of its greateft fupporters, fays, that it fucceeds better in cafes attend- ed with inflammation and increafed irritability than with atony and torpor. When given in large dofes, it certainly produces naufea, yorrtitingj diarrhoea, Vertigo and death. Its effeas on a morbid ftate of the body are alfo difputed. Some affert that it is of advantage in no difeafe ; while others beftOw upon it the moft unqualified praifes. By the latter, it is princi- pally celebrated, i« -. 1. In all cafes of fcrofula. 2. In obftruaions and tumors. 3. In cafes of worms;, r> 4. In cutaneous difeafes. , ,'r The dofe of the folution at firft, is five or teriidrops twice or thrice aday, to be gradually and cautioufly increafed to as much as the patient can bear. The folution is alfo ufed externally as a ftimulating and gently efcharotic application in cutaneous difeafes, fungous ulcers* and fpecks upon the cornea. AQUA CALCIS. Edin. Lime water. Take of Frefh burnt Ume, half a pound ; Put it into an earthen veffel, and gradually fbrinkle on it four ounces of water, keeping the veffel fhut, while the lime grows hot, and falls into powder. Then pour on it twelve pounds of water, and'mix the lime thoroughly with the water, by agitation. After the lime has fubfided, repeat the agitation ; and let this be done, about ten times, always keeping the veffel fhut, that the free accefs of the air may be prevented. , Laftly, let the water be filtered through paper, placed in a funnel, with glafs rods in- terpofed between them, that the water may pafs as quickly as poffible. It muft be kept in very clofe bottles. Lond. Take of Quicklime, half a pound ; , k Boiling diftilled water, twelve pints. Mix and fet them afide in a covered veffel for an hour; then pour off tbe liquor, which is to be kept in a elofe ftopt veffel. fST 2 414 Preparations and Compositions. [Part III. g Dub. Take of Lime recently burnt; Boiling water, each one pound. Put the Inne into an earthen veffel, and fprinkle the water upon it, keeping the veffel fhut while the lime grows warm andfalb into powder ; then pour upon it twelve pounds of water, and fhut the veffel, agitating it frequently for twentyfour hours ; laftly, filter the water through paper, placed in a covered fun- nel, and keep it in well clofed bottles. We have already had occafion to fpeak of the properties of lime (§ too. and p. 171.) and fhall therefore now confine our re- marks to the folution of it in water, commonly called Lime water. In making this, we fhould firft add only fo much water as is fuffi- cient to flake the lime, which reduces it to a fine powder, eafily diffufed through water ; for if we add more water at firft, it forms a pafte with the external part of the lime, and defends the inter- nal from the aaion of the water. During the whole procefs, the air muft be excluded as much as poffible ; as lime has a very ftrong affinity for carbonic acid, and attraas it from the atmof- phere. The proportion of water ufed is fcarcely able to diffolve one tenth of the lime ; but lime is of little value ; and our objeft is to form a faturated folution quickly and eafily. Lime.is not more foluble in hot water than in cold; therefore it is unneceffary to ufe boiling water. The London College decant their folution from the undiffolved lime ; but in this way we are not fo fure of a perfeaiy tranfparent folution as by filtration, and if we ufe the precautions direaed by the other Colleges, it may be performed without the lime abforbing a perceptible quantity of carbonic acid. The bottles in which lime water is kept, fhould be perfea- iy full, and well corked. Lime water is tranfparent and colorlefs. It has an auftere, ac- rid tafte, and affeas vegetable colors as the alkalies do.l It enters Very readily into combination with all the acids, fulphur and phof- phorus ; and decompofes the alkaline carbonates, phofphates, fili- ates, borates, oxalates, tartrites and citrates. When applied to the living fibre, lime water corrugates and fhortens it; it therefore poffeffes aftringent powers. It is alfo a powerful antacid, or at leaft it combines with and neutralizes acids when it comes in contaa with them. It alfo diffolves mucus, and kills internal worms. From poffeffing thefe properties, it is ufed in medicine, in difeafes fuppofed to arife from laxity and debility of the folids, as diarrhoea, diabetes, leucorrhcea, fcrofula, and fcurvy ; in affections of the ftotnach accompanied with acidity and flatulence ; when the inteftin'es are loaded with mucus ; and in worms. Lime water is fcarcely capable of diffolving, even out of the body, any of the fublhiuccs of which urinary calculi con- Chap. IV. Earths, and Earthy Sails. 415 fift ; it has therefore no pretentions to the charaaer of a lithon- triptic. It has been alfo recommended in crufta laaea, in can- cer, and in chronic cutaneous difeafes. Externally-^ is applied to ill conditioned ulcers, gangrenous fores; as a wafh in tinea cap- itis and pfora ; and as an injeaion in gonnorhoea, fiftulas and ul- cers of the bladder. When taken internally, its tafte is faid to be beft covered by lukewarm milk. Its dofe is commonly from two to four ounces, frequently repeated ; but when long continued it weakens the or- gans of digeftion. CARBONAS CALC1S PRvEPARATUS ; olim, Creta PRjEPARATA, et Cancrorum Lapilli j vulgo, Oculi Cancrorum PRjEPARATI. Edin. Prepared Carbonate of Lime ; formerly Prepared Chalk, and Crabs Stones, commonly called Crabs Eyes. Carbonate of lime, whether the fofter variety commonly called Chalk, or the harder variety called Crabs Eyes and Crabs Stones, after having been triturated to powder in an iron mortar, and levigated on a porphyry ftone with a little water, is to be put into a large veffel, and water to be poured upon it, which after agitating the veffel repeatedly is to be again poured off, while loaded with minute powder. On allowing the water to fettle, a fubtile powder will fubfide, which is to be dried. The coarfe powder which the water could not fufpend, may be levigated again, and treated in the fame manner. QUORUNDAM, AQUA NON SOLUBILIUM, PR.EPA- RATIO. Lond. The Preparation of fome Subflances not foluble in Water. Reduce thefe fubftances firft in a mortar to powder; and pouring on a little water, levigate it on a hard and polifhed, but not cal- careous ftone, that it may be made as fine as poffible. Dry this powder on blotting paper laid on chalk, and fet in a warm, or at leaft a dry place, far fome days. In this manner are to be prepared, Amber, Antimony, Calamine, Chalk, Coral, Crabs claws, firft broken into fmall pieces, and wafhed wi.;.. boiling water, Oyfter (hells, firft cleaned from impurities, - Tutty, Verdigris. 416 Preparations and Compositions. [Part III. CANCRORUM CHELAE PRiE-PARATA. Dub. Prepared Crabs Claws. Wafh the powdered claws in water mixed with about a fixth part of cauftic ley, until the adhering faline and animal particles be entirely feparated from the earthy particles, which are to be wafh- ed by frequently pouring upon them boiling water. With the additioli of a little water, they are then to be ground in a ftone- ware mortar to powder, which is to be mixed by agitation with a fufficiently large quantity of water. Atter a fhprt delay, that is, until the coarfer particles fubfide, the liquor is to be poured off. The fame procefs, by repeating the trituration, may be performed feveral times. Laftly, the very minute powder fwimming in the water poured off, is to be colleaed after it has fubfided, and dried upon paper placed on a bibulous ftone. J Creta Pr,eparat \. Prepared Chalk. Ostrearum Testae Prjep arat./£. Prepared Oyfter/hells. Ovorum Testae Pr^parat^e. Prepared Eggfnells. > Thefe are all to be prepared in the fame way as crabs claws. * The preparation of thefe fubftances merely confifts in reducing them to an impalpable powder ; which is effeaed by trituration' (§ 2.38.) and levigation (§2.49.) and the finer particles are fepa- rated rrom the coarfer by-elutriation (§2.43.) and afterwards from the water which fufpended. them, by fubfidence and decantation' (§ 2.41.) The foiuion of potafs is ufed by the Dublin College to diffolve the animal matter contained in the different (hells ; which is apt to keep the carbonate of lime too long fufpended, and to give it a bad fmell if not quickly dried. But thefe inconven- iences are totally avoided by ufing chalk, which, as a medicine, is not inferior 10 the coftly coral. . ' Carbon ite of lime is commonly called an Abforbent Earth. It certainly is au antacid ; that is, it combines with and neutralizes moft acids, whrie its carbonic acid is expelled in the form of gas. It is therefore exhibited in affctlions of the ftomach, accompanied with acidity, efpecially when at the fame time there is a tendency to diarrhoea. The fear of its forming concretions in the bowels, is probably imaginary ; for it is not warranted either by theory or experience. Applied externally, carbonate of lime may be confidered as an abforbent in another point of view; for its beneficial aaion on bums and ulcers, probably arifes entirely from its imbibing the moifture or ichorous matter, as a fponge would do, and thus pre- venting it from acting on the abraded furfaces, and excoriating the neighboring parts. Chap. IV.] Earths, and Earthy Salts. 417 SOLUTIO MURIATIS CALCIS. Edin. Solution of Muriate of Lime. Take of Pure carbonate of lime, that is, white marble, broken into piec- es, nine ounces ; Muriatic acid, fixteen ounces j Water, eight ounces. Mix the acid with the water, and gradually add the pieces of car- bonate of lime. When the effervefcence has ceafed, digeft them for an hour ; pour off the liquor and evaporate it to drynefs. Diffolve the refiduum in its weight and a half of water ; and, laftly, filter the folution. From the difficulty of cryftallizing this fait, it is direaed to be evaporated to drynefs, to the total expulfion of its water of cryftallization, as being the fureft way ot obtaining a folution of it of uniform ftrength. Its cryftals are prifms of fix fmooth and equal fides, but they are often fo aggregated that they can only be termed acicular. Its tafte is pungent, bitter and difagreeable. When heated, it melts, fwells, and lofes its water of cryftallization, and at a very1 high temperature a fmall part of its acid. It is one of the moft deli- quefcent falts that we know, and is fo foluble in water, that fluid feems capable ot diffolving twice its weight, or at leaft forms with it a vifcid liquid ; but as it is ftill capable of attraaing moifture from the air, and of emitting caloric when farther diluted, it can fcarcely be confidered as a true folution. It is foluble in alcohol, and its folution burns with acrimfon flame. It is decompofed by the fulphuric, nitric, phofphoric, fluoric and boracic acids ; by baryta, potafs, foda and ftrontia ; by rnoft of the fulphates, ful- phites, nitrates, phofphates, fluates, borates, and the alkaline car- bonates. Cryftallized, it contains 31 acid, 44 lime, and 25 wa- ter ; dried at a red heat 42 acid, 50 lime, and 8 water. It was firft propofed as a medicine by Fourcroy, in fcrofulous and glandular difeafes, and has been lately extolled with extrava- gant praifes by Dr. Beddoes in the fame affeaions. A drachm diluted with an ounce of water he confiders as a medium dofe. In an overdofe it has produced qualms and ficknefs ; and three drachms and a half killed a dog, the ftomach of which, upon dif- feaion, had its villous coat bloodfhot, and in many parts almoft thick and converted into a gelatinous (lime. The property of this fait, of producing intenfe cold during its folution, might alfo be applied to medical ufe. For this purpofe, it might be econom- ically prepared, by faturating with muriatic acid the refiduum of the diftillation of ammonia or of carbonate of ammonia. 4151 Preparations and Compositions. [Part. Ill PHOSPHAS CALCIS. Cornu Cervi Ustio. Lond. Cornu Cerv^numUstum Dub. Phofphate of Lime. Burnt Hartfhorn. Burn pieces of hartfhorn till they become perfeaiy white , then reduce them to a very fine powder. The pieces of horn generally employed in this operation, are thofe left after diftillation. In the burning of hartfhorn, a ftrong fire and the free admiffion of air are neceffary. The potter's furnace was formerly direaed for the fake of convenience ; but any common furnace or (love will do. If the pieces of horn be laid on fome lighted charcoal, fpread on the bottom of the grate, they will be burnt to white- nefs, ftill retaining their original form. According to the analyfis of Merat Guillot, hartfhorn was found to confift of 27. gelatine, 57.5 phofphate of lime, 1 carbo- nate ol lime, and there was a lofs of 14.5, probably water. Now as the gelatine is deftroyed by burning, and the water expelled, the fubftance which remains is phofphate of lime, mixed with lefs than two per cent, of carbonate of lime. From its white earthy appearance, it was formerly confid- ered as an abforbent earth. But fince it has been accurately an. alyzed, that idea has been laid afide, and its ufe has been fug- gefted as a remedy in rickets, a difeafe in which the deficiency of the natural depofition of phofphate of lime in the bones feems to be the effential or at leaft moft ftriking fymptom. M. Bonhom- rne, therefore, gave it to the extent ot half a fcruple, mixed with phofphate of foda, in feveral cafes with apparent fuccefs. What- ever objeaions may be made to his theory, the praaice certainly deferves a trial. MAGNESIA ; olim, Magnesia Usta. Edin. , Magnefia, formerly Calcined Magnefia. Let carbonate of Magnefia, put into a crucible be kept in a red heat for two hours, then put it up in clofe ftopt glafs veffels. Magnesia Usta. Lond. Dub. Calcined Magnefia. Take of White magnefia, four ounces. IHxpofe it to a ftrong heat for two hours ; and, when cold, fet it by. Keep it in a glafs veffel clofely ftopt. By this procefs the carbonate of magnefia is freed of its acid Chap. IV.] Earths, and Earthy Salts. 419 and water ; and, according to the late Dr. Black's experiment, lofes about -^ of its weight. A kind of opaque foggy vapor is obferved to efcape during the calcination, which is nothing elfe than a quantity of fine particles of magnefia, buoyed off along with a ftream of the difengaged gas. About the end of the ope- ration, the magnefia exhibits a kind of luminous or phofphorefcent property, which may be confidered as a pretty exatl criterion of its being deprived of its acid. It is to be kept in clofe veffels, becaufe it attraas, though (low- ly, the carbonic acid of the atmofphere. We have already (90) noticed its general chemical properties. In medicine it is ufed for the fame general purpofes as the carbo- nate. In certain affeaions of the ftomach, accompanied with much flatulence, magnefia is preferable, both becaufe it contains more magnefia in a given quantity, and, being deprived of its acid, it neutralizes the acid of the ftomach, without any extrication of gas, which is often a troublefome confequence when carbonate of magnefia is employed in thefe complaints. CARBONAS MAGNESIA; olim, Magnesia Alba. Edin. Carbonate of Magnefia, formerly Magnefia Alba. 'Take of Sulphate of magnefia, Carbonate of potafs, equal weights. Diffolve them feparately in double their quantity of warm water, and let tbe liquors be ftrained or otherwife freed from the feces : then mix them, and inftantly add eight times their quantity of warm water. Let the liquor boil for a little on the fire, ftirring it at the fame time ; then let it reft till the heat be fomewhat diminifhed ; after which ftrain it through linen ; the carbonate of magnefia will remain upon the cloth, and it is to be wafhed with pure water till it become altogether void of faline tafte. Magnesia Alba. Lond. Dub. White Magnefia. Take of Vitriolated magnefia, Prepared kali, each two pounds ; Diftilled water, boiling, twenty pints. Diffolve the vitriolated magnefia and prepared kali feparately, each in ten pints of water, and filter through paper ; then mix them. Boil the liquor a little while, and ftrain it whilft hot through linen, upon which will remain the white magnefia ; then wafh away, by repeated affufions of diftilled water, the vi- triolated kali. 420 Preparations and Compositions. [Part. III. The formula of the Dublin College does not differ from that of London, except in direa'.ng 'hat the linen ftrainerbe ftretchedout fo as to fit it for collecting »h« magiit fia. In this procefs there is a mutual decompofition of the two falts employed. The potafs unites itidf to the fulphuric acid, while the carbonic acid combines with the magnefia. The large quan- tity of water ufed is neceffary for the foluion of the fulphate of potafs formed ; and the boiling is ind:lpenfably requifite for the Expulfion of a portion of the carbonic acid, which retains a part of the magnefia in folution. Sulphate of potafs may be obtained from the liquor which paffes Jnough the filter, by evaporation. This is not pure, however, but mixed with undecompofed carbo- nate of potafs ; for ioo parts oi cryftallized carbonate of potafs are fufficient for the decompofition of ta^ parts of fulphate oi magnefia ; and as the carbonate ot potafs of commerce contains a larger proportion of alkali than the cryftallized carbonate, a ftill lefs proportion fhould be ufed. From thefe quantities about 45 parts of carbonate of magnefia are obtained. The ablutions fhould be made with pure water ; for nicer pur- pofes diftilled water may be ufed, and foft water is in every cafe neceffary. Hard water for this procefs is peculiarly inadmiffible, as the principle of waters, giving the property called hardnefs, is generally owing to a fait of lime, which decompofes the car- bonate of magnefia, by compound affinity, giving rife to car- bonate of lime, while the magnefia unites itfelf to the acid of the calcareous fait, by which the quantity of the carbonate is not on- ly leffened, but is rendered impure by the admixture of carbonate of lime. Another fource of impurity is the filica which the fub- carbonate of potafs generally contains. It is moft eafily got rid off by expofing the alkaline folution to the air for feveral days be- fore it is ufed. In proportion as it becomes faturated with car- bonic acid, the filica is precipitated, and may be feparated by fil- tration. The carbonate of magnefia thus prepared is a very light, white, opaque fubftance, without fmell or tafte, effervefcing with acids. It is not, however, faturated with carbonic acid. By decompo- fing fulphate ot magnefia by an alkaline carbonate, without the application of heat, carbonate of magnefia is gradually depofited in tranfparent, brilliant hexagonal cryftals, terminated by an ob- lique hexagonical plane, and foluble in about 480 times its weight ofwater. The cryftallized carbonate ot magnefia confifts of 50 acid, 25 magnefia, and 2,5 water ; the fu bear bonate .confifts of 48 acid, 40 magnefia, and 12 water ; and the carbonate of commerce of 34 acid, 45 magnefia, and 21 water. It is decompofed by all the acids, potafs, foda, baryta, lime and flrontia, the fulphate, phofphate, nitrate, and muriate of alumina, and the fuperph^fphaje of lime. Chap. IV.] Earths, and Earthy Salts. 421 Carbonate of magnefia is principally given to correa acidity of the ftomach, and in thefe cafes toacf as a purgative; for folutions of magnefia in all acids are bitter and purgative ; while thofe of the other earths are more or lefs auftere and aftringent. A large dofe of magnefia, it the ftomach contain no acid to diffolve it, neither purges nor produces any fenfible effea ; a moderate one, if an acid be lodged there, or it acid liquors be taken after it, pro- cures feveral (tools; whereas the common abforbents, in the fame circumftances, inftead of loofening, bind the belly. When the carbonate of magnefia meets with an acid in the ftomach, there is extricated a confiderable quantity of carbonic acid gas, which fometimes caufes uneafy diftention of the ftomach, and the fymp- toms ot flatulence. In fuch cafes therefore, magnefia is prefer- able to its carbonate ; but on other occafions good effeas arife from the aaion of the gas evolved, as in naufea and vomiting. U ALUMINIS PURIFICATIO, Lond. Purification of Alum, Take of Alum one pound ; Chalk one drachm ; Diftilled water one pint. Boil them a little, ftrain, and fet the liquor afide to cryftallize. This procefs is fcarcely neceffary ; for the alum of commerce is fufficiently pure for every purpofe ; and we apprehend that the addition of the chalk is unchemical, as its only effefcl will be to decompose part of the alum, without contributing to the purity of tie reft. •■••■. SULPHAS ALUMINA EXSICCATUS ; olim, Alumen Ustum. Edin. Dried Sulphate of Alumine, formerly Burnt alum. Melt alum in an earthen or iron veffel, and keep it over the fire ' .until it ceafe to boil. Alumen Ustum. Lond. . Burnt Alum. Take of - Alum, half a pound. Burn it in an earthen veffel as long as i^ boils. Dub. Take of Alum any quantity. Expofe it in an earthen veffel to a ftrong fire until it ceafe to bo!: 422 Preparations and Compositions. [Part III. Mr. Chaptal found that by exficcation in red heat, alum of his own manufaaure loft 0.67 ; Roman alum 0.50; Englilh alum 0.47, and Levant alum only 0.40. Thefe differences arife princi- pally from different proportions of water of cryftallization, but alfo form an excefs of alumina, which the laft contains. According to Kirwarf, cryftallized alum confifts of 17 66 acid, 12. alumina, and 70.24 water, and alum deficcated at yoo°of 36. 25 acid, and 63.75 batis, by which it would appear that at that heat it lofes not only all its water, but alfo more than half its acid. Dried alum is only applied externally as a gentle efcharotic to fungous ulcers. CHAP. V. METALLINE PREPARATIONS, ANTIMONY. SULPHURETUM ANTIMONII PR^EPARATUM; olim, Antimonium Pr^eparatum. Edin. Antimonium Prseparatum. Lond. Prepared Sulphuret of Antimony, formerly Prepared Antimony^ Sulphuret of antimony is prepared in the fame way as carbonate of lime (p. 415.) Stibium PrjEparatum. Dub. Prepared Antimony. \\. is reduced to powder, and the impalpable particles, which are to be kept for ufe, are procured in the manner direaed for the preparation of crabs claws. By reducing the fuiphuret of antimony to the ftate of an im- palpable powder, it is both rendered much more aaive than it would otherwife be, and it is prevented from irritating the ftom- ach mechanically, of which there would be fome danger from the (harpnefs of its fpiculae. Even in this ftate, however, it is not a very certain remedy. In general it operates as a very mild fu- dorific or cathartic ; but fometimes, if it meet with much acid in, the ftomach, it becomes more aaive, producing vomiting or hy- percatharfis. Therefore, it feems prudent to evacuate the prims Chap. V.] Of Antimony. # 423 vise before it be exhibited, and to combine it with an abforbent earth. It is principally given in fcrofula, glandular obftruaions, cuta- neous difeafes and rheumatifm. Its dofe is from 10 to 30 grains and upwards, and it is beft exhibited in the form of a powder or bolus. OXIDUM ANTIMONII CUM SULPHURE, PER NI- TRATEM POTASS^E; olim, Crocus Antimonii. Edin. Oxide of Antimony, with Sulphur, by Nitrate of Potafs, formerly Crocus of Antimony. - Take ot Sulphuret of antimony, Nitrate of potafs, equal weights. After they are feparately powdered and well mixed, let them be injeaed into a red hot crucible ; when the deflagration is over, feparate the reddifh'metallic matter from the whitifh cruft; powder it and edulcorate it by repeated wafhings with hot wa- ter, till the water come off infipid. Crocus Antimonii. Lond. Stibium Nitro Calcinatum. Dub. Crocus of Antimony. Antimony Calcined by Nitre. Take of Antimony, powdered, Nitre powdered ; of each one pound ; Sea fait, one ounce. Mix, and injeathem by degrees into a red hot crucible, and melt them, having augmented the heat. Pour out the melted mat- ter ; and, when cold, feparate it from the fcorice. In this procefs, the nitric acid of the nitre is decompofed ; the antimony is oxidized to that degree in which it forms the orange oxide of Thenard, containing o. 18 oxygen ; part of the fulphur is acidified, and combines with the potafs of the nitre, while the re- maining fulphur combines with the oxide of the antimony, and forms a dark brown, opaque, vitrified mafs ; fo that after the fco- riae and other faline matters have been removed by warning, the fubftance which remains is a fulphuretted oxide of antimony.* With regard to the mode of preparation, Bergmann obferves, that by the common procefs of throwing the mixture into an ig- nited uncovered crucible, there is fometimes a lofs of nearly one * According to Prouft, it confifts of three n*.:ts of oxide of antimony, and one »f fuiphuret of antimony. 424 Preparations and Compositions. £Part IH*> • half, and therefore advifes the mixture to beput into a cold'cruci- ble, which is to be covered and heated till the matter melts, by which rqeans there is very little lofs. What is kept in the fhops, is almoft univerfaliy prepared with, lefs nitre than is here ordered. The confequence is, that too much. fulphur remains not acidified, the antimony is fcarcely oxidized, and the preparation is unfit for the ufes to which it ought to be applied. When nitre has been thus culpably econpmized, the crocus has a fteel gray, inftead of a liver brown color. The ad- dition of common fait, directed by the Dublin and London Col- leges, is improper, as it is decompofed, artd a portion of muriate ot antimony is formed. The fulphuretted oxide of antimony is a very tincertain prepa- ration, often operating with very great violence. Its internal ufe is therefore almoft profcribed, or at leaft confined to maniacal cafes, and veterinary praaice. It is however ufeful in pharmacy, as the bafis of other preparations. OXIDUM ANTIMONII, CUM SULPHURE, VITRIFI- CATUM ; olim, Vitrum Antimonii. Edin. Vitrified Oxide of Antimony with fulphur, formerly Glafs of An- timony, Strew Sulphuret of antimony beat into a coarfe powder like fand, upon a (hallow unglazed earthen veffel, and apply a gentle heat underneath, that the antimony may be heated flowly ; keep- ing it at the fame time continually ftirring, to prevent it from run- ning into lumps. White vaporS of fulphureous fmell will arife from it. When they ceafe with the degree of heat firft applied, increafe the fire a little, fo that vapours may again arife ; go on in this fame manner, till the powder, when brought to a red heat, exhales no more vapors. Melt this powder in a crucible with ail intenfe heat, till it affumes the appearance of melted glafs ; then pour it out on a heated brafs plate. Antimonium Vitrificatum. Lond. Vitrified Antimony. Take of Powdered antimony, four ounces. Calcine it in a broad earthen veffel with fire gradually raifed, ftir- ring it with an iron rod until it no longer emit fmoke. Put this powder into a crucible, fo as to fill two thirds of it. A cover being fitted on, make a fire under it, at firft moderate, af- terwards ftronger, until the matter be melted. Pour out tbe melted glafs. Chap. V.] Of Antimony 42B By this procefs, the fuiphuret of antimony is deprived of the greateft part ot its fulphur, while the antimony is at the fame time oxidized, fo as to form the dark brown oxide of Thenard, containing 0.16 of oxygen. But as this preparation is not eafily made in the manner here direaed, unlefs in a furnace conftruaed on purpofe, apothecaries may advantageoufly adopt the fynthe- tical method of Bergmann, which confifts in melting in a crucible^ with one twelfth or eighth of its weight of fulphur, antimony ox- idized to a maximum, by deflagrating it with more than twice its weight of nitre. At the temperature neceffary for melting it, the oxide of antimony lofes great part of its oxygen, and combines with the fulphur.* In whichever way prepared, the glafs of antimony is tranfpa- rent', and has a fine hyacinthine color. On diffolving it in mu- riatic acid, it gives out fulphuretted hydrogen gas, which (hows that it is a hydroguretted fuiphuret of antimony. Its operation is fo uncertain, that it is only ufed in making other preparations. OXIDUM ANTIMONII V1TRIFICATUM, CUM CERA; olim, Vitrum Antimonii Ceratum. Edin. Vitrified oxide of Antimony with Wax ; formerly Cerated Glafs of Antimony. Take of Yellow wax one part, Glafs of antimony eight parts ; Melt the wax in an iron veffel, and throw into it the powdered glafs ; roaft the mixture over a gentle fire for a quarter of an hour, continually ftirring it ; then pour it out, and when cold grind it into powder. The glafs melts in the wax with a very gentle heat; after it has been about twenty minutes on the fire, it begins to change its eolor, and in ten more comes near to that of Scottifh fnuff; which is a mark of its being fufficiently prepared ; the mixture lofes about one ninth of its weight in the procefs. This medicine was for fome time much efteemed in dyfente- ries. The dofe is from two or three grains to twenty, according to the age and ftrength of the patient. In its operation it makes fome perfons fick, and vomit, it purges almoft every one ;— though it has fometimes effeaed a cure without occafioning any evacuation or ficknefs. It is now, however, much lefs ufed than formerly. , * Since the above was written, it appears from Mr. Prouft's experiments, that glaf; of antimony confifts of about 8 parts of oxide of antimony at the minimum, end ons Of lulphuret of antimony. 426 Preparations and Compositions. [Part III* SULPHUR STIBIATUM FUSCUM, olim, Kermes Mine- ralis. t Dub. Brdwn Antimoniated Sulphur ,* formerly Kermes Mineral. Take of Prepared antimony, Mild vegetable alkali, each one ounce. Melt them together in a crucible, and when cold reduce the fub- ftance to powder. Put this into a matrafs with five pounds of pure water, and boil for an hour. Then remove the veffel from the fire ; let it ftand at reft for a little time, and as foon as the liquor becomes clear, pour it cautioufly from the fedi- ment. When the liquor grows cool, the brown antimoniated fulphur will feparate, which is to be dried on paper. According to Thenard, the brown precipitate confifts of 72.760 brown oxide of antimony. 20.298 fulphuretted hydrogen. 4.156 fulphur. 2.786 water and lofs. 100 He confiders kermes mineral, therefore, as a fulphuretted hy. droguret of antimony, efpecially as it differs from that which is prepared by the direa combination of its conftituents, only in containing a fmall quantity of fuperabundant fulphur. When the fuiphuret of antimony and carbonate of potafs are melted together, the carbonic acid is expelled with effervefcence, and a fuiphuret of antimony and potafs is formed. On boiling this in water, water is decompofed, the antimony is oxidized, and the hydrogen combines with the fulphur. The fulphuretted hy- drogen thus formed, combines partly with the potafs, and partly with the oxide of antimony. Now, the fulphuretted hydroguret of brown oxide of antimony, (kermes mineral) is foluble in a fo- lution of fulphuretted hydroguret of potafs, at 212°, but not at ordinary temperatures. Therefore, on cooling, it feparates and falls to the bottom. Such is the prefent theory of the formation of kermes mine- ral. With regard to the praaice, the direaions of the Dublin College differ confiderably, efpecially in the proportions ot the fubftances employed, from the bed pharmaceutical writers on the Continent. Lemery melted fixteen parts of fuiphuret of antimo- ny, and one of fulphur, with eight parts of carbonate of potafs. The laft edition ot the Pruflian Pharmacopoeia direas two parts of fuiphuret of antimony, and one of exficcated carbonate of foda, to be melted, and afterwards boiled fifteen minutes in fix or eight parts of water, which on cooling depofites a confiderable quantity of kermes. Tbe fluid from which the kermes has,been depofi- Chap. V.] Of Antimony. 427 ted may be again boiled in the refiduum of the firft decoaidn, and it will diffolve a frefh portion of kermes, and this procefs may be repeated as long as there remains any to diffolve. Alter this, the refiduum when melted confifts almoft folely of anti- mony. It therefore appears, that the alkali renders almoft all the fulphur foluble,and only difpofes the oxidizement of as much.an- timony as is capable of combining with the fulphuretted hydro- gen. We fee no reafon Why the whole of the antimony fhould not be converted into kermes by employing a proper addition of fulphur and alkali. Kermes is alfo made in the humid Way. Fourcroy boils ifi twenty parts of water, fix parts ot pure potafs of commerce, and into the boiling folution throw i about the twentieth part of the weight of the alkali, or o.^ of a part of powdered fuphuiet of an- timony, and continues the boiling for feven or eight minutes, then filters and allows the keimes to precipitate by cooling. Hermb- ftadt ufes very different proportions ; for he boils twelve pans of fuiphuret of antrnony, and three of fait of tartar, in ninety- fix parts of water, down to fixtyfour, and then filters, &c. Gr'eri employs four parts of fuiphuret ot antimony, fixteen of carbonate ef potafs, and fixtyfour of water, and boils for feveral hours. This preparation of antimony is lefs ufed in Britain ti.an on the Continent. It is an aaive fubftance, and apt to excite vomit- ing. To adults, the dofe is a grain, or a grain and a half. SULPHURETUM ANTIMONII PR/EClPITATt/M. Edin. Precipitated Sulphuret of Antimony. Take of ' Water of potafs, four pounds ; Water, three pounds ; Prepared fuiphuret of antimony, two pounds j Boil them in a covered iron pot. over a-(low fire for three hours adding more water, if neceffary, and frequently ftirring the mixture with an iron fpatula ; ftrain the liquor while warm through a double cloth, and add to it when filtered as much di- luted fulphuric acid as is neceffary to precipitate the fuiphuret, which muft be well wafhed with warm water. Sulphur. Antimonii PrAcipitatum. Lond. Precipitated Sulphur of Antimony. Sulphur StibiaiUm Rufum'. Dub. Orange Antimoniated Sulphur. The directions of thefe Colleges only differ from thofe of the* Edinburgh College in the nomenclature. D j> 428 Preparations and Compositions. [Part III. This is alfo, according to the analyfis of Thenard, a fulphuret- ted hydroguret of antimony, which confifts of 68 3 orange oxide of antimony. 17.877 fulphuretted hydrogen. 12. fulphur. 98.177 Thenard confiders the fulphur as only mechanically and acci- dentally mixed ; and that the effential difference between this preparation and kermes mineral confifts in the degree of oxidize- ment of the antimony. The precipitated fuiphuret of antimony, like the kermes, may be prepared either in the dry or in the moift way. The latter is the mode adopted by the Britifh Colleges, and alfo feems to bethe moft univerfaliy employed on the Continent. Gottling boils two parts of fuiphuret of antimony, and three of fulphur, in a fufficient quantity of a recent folution of potafs, filters the folution, and pre- cipitates with fulphuric acid, diluted with twelve times its weight of water. Wiegleb treats in the fame manner two part's of fui- phuret of antimony with one of fulphur. But to his proportions it has been objeaed, that the produa refembles kermes more than fulphur auratum. If this objeaion be juft, it muft apply in a ftill ftronger degree to the formula of the Britifh Colleges, in which no fulphur is added. In the dry way, two parts of fuiphuret of antimony and three of fulphur may be melted with five of pure carbonate of potafs in a covered crucible, as quickly as poffible, poured into an iron mortar, reduced to powder, and diffolved by boiling the powder in water. The folution is to be filtered warm, diluted with a fuf- ficient quantity of water, and precipitated with dilute fulphuric acid. By fome, the folution is allowed to remain at reft for twentyfour hours before it be filtered, and fome precipitate with nitrous acid. The proceffes for making the golden fuiphuret of antimony, de- pend on the property which the hydroguretted fuiphuret of potafs poffeffes, of diffolving, and retaining diffolved, even at ordinary temperatures, a portion of orange oxide of antimony ; and as the attraaion by which potafs exifts in this compound is weaker than its affinity for acids, on the addition of any acid, the potafs unites with the acid ; a portion of fulphuretted hydrogen gas efcapes; and the oxide of antimony,combined with the reft ot the fulphur and hy- drogen,are precipitated in the form ot a light orange powder. When the acid is added gradually, the proportion of oxide of antimony al- ways decreafes, while that of the fulphur increafes in each fuccef- live portion of precipitate. Hence in the old manner ot prepar- ing this fubftance from the fcoriae, formed in reducing antimony from its fuiphuret, and which contained but little fulphur, the two firft portions of precipitate, being dark colored, were rejeaed. Chap. V»] Of Antimony, 42$ and only the produa of the third precipitation retained for ufe. The want of economy in this procefs is fufficiently obvious, as well as the very great improvement in modern times, of adding a fufficient quantity of fulphur, and precipitating the whole at once. Notwithftanding the great celebrity of Thenard as a chemift, and his having paid particular attention to the combinations of antimony, we may be allowed to doubt the accuracy of his opin- ion refpeaing the effential difference between kermes mineral and the golden fuiphuret of antimony, until he publifhes the ex- periments on which it is founded. It appears to us, that it will be extremely difficult, if not impoflible,to prove in fuch fubftances a difference ef only 2 per cent, of oxidizement. If he fhould fail in his attempt to prove it, the only apparent difference between thefe bodies will be in the proportion of fulphur they contain. For it is agreeable to analogy to fuppofe, that the fulphuretted hydroguret of antimony is more foluble in a folution of hydro- guretted fuiphuret of potafs at 2120, than at 6o°. Therefore, as a boiling folution cools, that portion of the fulphuretted hydro- guret of antimony, which it is unable to retain in folution at a re- duced temperature, feparates and forms the red precipitate, known by the name of Kermes Mineral; but the portion which remains in folution, can only be obtained by decompofing the hydroguretted fuiphuret of potafs itfelf, by means of an acid j and therefore the precipitate forming the fulphur auratum antimonii, is a mixture or compound of hydroguretted fuiphuret of antimony and fulphur, which gives it a brighter and paler color.* * Since the above obfervations were written, we have feen a paper upon antimony by Prouftjpublifhed injthe Journal de Phyfique, vol. 55. and in which we were agreeably flattered to find, that many of our conje&ures refpefting the nature of the antimonial preparations were confirmed by the experiments of that excellent chemift. We can only infert fome of his general conclufions at prefent. We have two oxides of antimony • the one containing 23, and the other 30 per cent. of oxygen. The firft is very fufible, opaque, and cryftalline. It is the bafis of the common faline preparations of this metal, fuch as the muriates and tartrites. The fecond does not readily enter into the fame combinations, and follows the fame law with feveral other metals, at the maximum of oxidizement. Antimony, at its minimum of oxidizement, cannot go beyond that degree, without attaining its maximum, nor be reduced below it, without being reduced to its metallic ftate. The oxides, both at the minimum and maximum, are incapable of forming any u- nitan with fulphur. The former is capable of diffolving the iulphuret of antimony ; and acquires by that union, thole vitreous and hepatic properties, whichbelong to thofe compounds hitherto confidered as fulphuretted oxides of antimony. The latter feems aito capable of forming the fame combinations, but only by lofing its excefs of oxygen above the minimum. The oxide at the minimum can unite with fulphuretted hydrogen, and forms twa compounds, kermes, and fulphur auratum. The former is well known, the latter very little, for we do not rightly underftand in what it differs from the former. The oxide at the maximum, is incapable of entering into this combination) 430 Preparations and Compositions. [Part III. In its aaion on the body, the orange fuiphuret of antimony co- incides with the kermes mineral; but on account of the larger proportion of fulphur, it muft be given in fomewhat larger doles. MURIAS ANTIMONII. Edin. Muriate of Antimony Take of Oxide ot antimony with fulphur, by nitrate of potafs, Sulphuric acid, each one pound ; Dried muriate of foda, two pounds. Pour the fulphuric acid into a retort, gradually adding the muri- ate of foda and oxide of antimony previoufly mixed. Then per- form the diftillation in a fand bath. Expofe the diftilled mat- ' ter for feveral days to the air, that it may deliquefce, and then pour tbe liquid part from the feces. A ntimonium Muriatum. Lond. Muriated Antimony. Stibium Muriatum Causticum. Dub. Cauftic Muriated Antimony. The proceffes of thefe Colleges are effentially the fame with that of the Edinburgh College. The antimony in this preparation, according to Thenard, is in the fifth degree of oxidizement, and contains 0.20 of oxygen. It is the fame with the oxide obtained from antimony by fublima- tion. The muriate of antimony may be formed by diffolving the fublimed oxide direaiy in muriatic acid, or by leaving antimony long immerfed in it. In the latter cafe it becomes flowly oxidiz- ed by decompofing the water, and is then diffolved. Some dif- ferences have been faid to exift between the muriates different- ly prepared, but they are not afcertained. Muriate of antimony was formerly prepared by diftilling fuiphuret of antimony with muriate of quickfilver. Muriate of antimony paffes over into the receiver, and black fuiphuret of quickfilver remains in the retort. But this mode of preparation is both expenfive and dan- gerous. In the procefs directed by the Colleges, the fulphuric acid decompofes the muriate of foda, and the muriatic acid, difengaged diffolves and carries over with it the oxide of antimony. It is at firft obtained in the ftate of a thick fubftance, which from its ap- pearance got the name of Butter of Antimony ; but by expofing it for fome days to the aaion of the air, it attraas humidity until it become faturated with it. We have already obferved, that the oxide of antimony made ufe of in this preparation, is feldom fuffi- Chap. V.] Of Antimony. 431 ciently oxidized or deprived of its fulphur ; and when this is the cafe, there is confiderable danger of the veffel burfting, from the great quantity ot fulphureous vapours difengaged, and the produa is rendered, lejfs pure from the admixture of fulphur. But thefe inconveniences are prevented, according to Gottling. by ufingthe glafs of antimony. He introduces into a retort a mixture of four ounces of glafs of antimony in powder with fixteen of muriate of foda, and then pours into it twelve ounces of fulphuric acid, dilut- ed with eight of water. He lutes on a receiver with gypfum, and diftils to drynefs in a fand bath, with a heat gradually increafed. By this procefs, he fays, about twenty ounces of very ftrong fum- ing muriate of antimony are obtained. The refiduum in the retort is fulphate of foda, but unfit for internal ufe, on account of its being mixed with fome antimony. Muriate of antimony may be ufed as an efcharotic, but it is principally employed in the formation of the-next article. CALX ST1B1I PR^CIPITATA. Dub. Precipitated Calx of Antimony. Take of Mild vegetable alkali, Cauftic muriated antimony, each eight ounces; Water, forty pounds. Diffolve the vegetable alkali in the water, and to the filtered li- quor add the cauftic muriated antimony. Dry the calx which fubfides, after wafhing away the faline matters. This procefs is intended to feparate the oxide contained in the muriate of antimony, by means of the fuperior affinity which po- tafs poffeffes for muriatic acid. It is abfolutely neceffary that the muriate of antimony be poured into the alkaline folution, and not the folution into the muriate ; for the muriate is partially de- compofed by water alone, which combines with part of the acid; and the fait, brought to the ftate of an infoluble fubmuriate, is precipitated. Therefore, if we pour the alkaline folution into the muriate of antimony, the muriateaas firft upon the alkali,and im- mediately afterwards upon the water of each portion of the folu- tion ; and therefore we obtain a mixed precipitate of oxide ot an- timony and fubmuriate of antimony. But it we pour the mu- riate into the alkaline folution, the whole acid of each portion of the muriate immediately finds a fufficient quantity of alkali to fa- turate it, and the whole, or at leaft a much larger proportion of the antimony, is precipitated in the ftate of oxide. The oxide thus obtained, according to Thenard, contains 80 of antimony, and 20 of oxygen, and is the fifth oxide of antimony. It is only ufed in making other preparations. 432 Preparations and Compositions. [Part III. OXIDUM ANTIMONII cum PHOSPHATE CALCIS ; olim, Pulvis Antimonialis. Edin. Oxide of Antimony with Phofphate of Lime, formerly Antimonial Powder. Take of Sulphuret of antimony, in coarfe powder, Shavings of hartfhorn, equal weights. Mix, and put them into a wide red hot iron pot, and ftir the mix- ture conftantly, until it be burnt into a matter of a gray color, which is then to be removed from the fire, ground into powder, and put into a coated crucible. Lute to this crucible another inverted over it, and perforated in the bottom with a fmall hole, and apply the fire, which is to be raifed gradually, to a white heat, and kept in that increafed ftate for two hours.__ Laftly, grind the matter, when cold, into a very fine powder. Pulvis Antimonialis. Lond. Pulvis Stibiatus. Dub. Antimonial Powder. The direaions of thefe Colleges are exaaiy the fame with thofe already given. This is fuppofed to be nearly the fame with the celebrated noftrum of Dr. James, the compofition of which was afcertained by Dr. Pearfon of London, and to him we are alfo indebted for the above formula. By burning fuiphuret of antimony and (havings of hartfhorn in a white heat, the fulphur is entirely expelled, and the antimony is oxidized, while the gelatine of the hartfhorn is deftroyed, and nothing is left but phofphate of lime, combined with a little Yime. Therefore, the mafs which refults is a mixture of oxide of anti-' mony and phofphate of lime, which correfponds, at leaft as to the nature of the ingredients, with James's powder.which by Dr.Pear- fon's analyfis, was found to confift of 43 phofphate of lime, and 57 oxide of antimony. Another excellent chemift, Mr. Chenevix, has lately propofed a method of forming the fame combination in the humid way, with the view of obtaining a preparation always fimilar in its compofition and properties. He was led to this pro- pofel by confidering the uncertainty of the application, and the precarious nature of the agency of fire, by which means a variable portion of the ©xide of antimony may be volatilized, and that which remains may be oxidized in various degrees. Mr. Chenevix therefore propofes to prepare a fubftitute for James's powder, by diffolving together equal weights of fubmu- riate of antimony, and of phofphate of lime, in the fmalleft poffi- ble quantity of muriatic acid, and then pouring this folution grad- ually into water fufficiently alkalized with ammonia. For the rea- Chap. V.] Of Antimony. 433 fon mentioned in the preceding article, it is abfolutely neceffary that the muriatic folution be poured into the alkaline liquor. By an oppofite mode of procedure, the precipitate would contain more antimony at firft, and towards the end the phofphate of lime would be predominant, and the antimony would be partly in the ftate of a fubmuriate. The phofphate of lime is moft conveniently ob- tained pure by diffolving calcined bone in muriatic acid, and by precipitating it by ammonia. If the ammonia be quite free from carbonic acid, nomwriate of lime is decompofed. Mr. Chenevix alfo found, that his precipitate is entirely foluble in every acid which can diffolve either phofphate of lime or oxide of antimony feparately, and that about 0.28 of James's powder, and at an aver- age 0.44 of the pulvis antimonialis of the London Pharmacopoeia, refift the aaion of every acid. The oxide of antimony with phofphate of lime, howfoever pie- pared, is one of the beft antimonials we poffefs. It is given as a diaphoretic in febrile difeafes, in dofes of from three to eight grains, repeated every third or fourth hour. In larger quantities, it operates as a purgative or emetic. From its being infoluble in water, it muft be given either in the form of a powder, or made into a pill or bolus. TARTRIS ANTIMONII; olim, Tartarus Emeticus. Edin. Tartrite of Antimony, formerly Tartar Emetic. Antimonium Tartarisatum. Lond. Tartarized Antimony. Take of Oxide of antimony with fulphur, by nitrate of potafs, three parts ; Supertartrite of potafs, four parts ; Diftilled water, thirty two parts. Boil in a glafs veffel for a quarter of an hour, ftrain through pa- per, and fet afide the drained liquor to cryftallize. Tartarum Stibiatum. Dub. Antimoniated Tartar. Take of The precipitated calx of antimony, two ounces; Cryftals of tartar in very minute powder, four ounces; Diftilled water, five pounds. Boil until the powders be diffolved, and ftrain the liquor when cold through paper ; then having thrown away the fait which re- mains upon the paper, cryftallize by evaporation and flow re- frigeration. The cryftals fhould have a regular figure. 03=4 434 Preparations and Compositions. [Part III. The tartarous acid is capable of combining, in many examples, yith two bafes at the fame time, foitinng with them triple cryf- tallizable falts. In the prefent inftance, u is coii'bined vvuh oxide bf antimony and potafs; and as thepoijfs is ellential to its con- • iftitution, and the real tartrite of antimony is a different fait, its, name (hould certainly have been Tartnte of Antimony and Pot- afs. In the preparation of this fait, the different combinations of oxide of antimony have been employed. Any of them will af- ford a very pure fait, provided the antimony is in that ftate of oxidizement in which it contains about 0.20 of oxygen. The crocus, precipitated oxide, fubmuriate, and gials, are all occafion- ally employed. The London and Edinbuigh Colleges ufe the crocus. To this the principal objeaion is, that it is never found in the fh >ps in a date fit for this purpofe. The Dublin College ufe the precipitated oxide, which anfwers extremely well, but is too expenfive to be generally adopted. The fubmuriate, which is more eafily prepared!, is juft as good ; for the muriatic acid is completely feparated by part of the potafs, and remains in the mother water. The glafs is perhaps "the leaft objeaionable of any, and is recommended by Gottling. It always, however, con- tains about 0.1 of filica. The quantity of water employed muft be fufficient to diffolve the tartar emetic formed. The time dur- ing which the ebullition is to be continued, is ftated differently by different pharmaceutifts. No harm can arife from continuing it longer than is abfolutely neceffdry ; but it is certainly a wafle of time and fuel to protraa it for hours. But the circumftance which renders the tartar emetic moft variable in its effeas, is the mode ot cryftallization. Some evaporate it to drynefs ; others to a pellicle", and fet it afide to cryftallize ; and others again cryftal- lize by flow evaporation. Qn account of the filica which is combined with the oxide of antimony, and which being held in folution by the potafs, impedes the cryftallization, and varies the nature of the produa, Vduquelin recommends the folution to be firft evaporated' to drynefs,* and that the fjline mafs obtained fhould be rediffolved in boiling water, and then cryftallized : For, towards the end of the firft evaporation, the filica feparates, and/ becomes totally infoluble.' In this way, he fays, that we obtain both a purer fait, and in larger quantity. Thenard has alfo fhe*vn, that tartar emetic often contains tartrite 6f lime, which cryftal- lizes in 'fjlky needles, arranged around a cornrnon, centre; he therefore advifes us not to evaporate farther the mother water, efpecially ot the firft cryftallization; and to cryftallize the tar- trite of potafs and antimony at leafttwice. We have alfo obferved it. A faturated boiling folution of tartar emetic was fuffered to cryf- tallize in a moderate temperature; the mother water was theft poured off, and accidentally expofed to a confiderably lower tco»- Chap. V.] Of Antimony. 433 perature ; a new cryftallization of ftars of fine filky needles im- mediately took place. It we employ an excefs of fupertai :nte of potafs, part of it wili remain undecompofed, and wi.l cryftal- lize before or along with the tartar emetic. This fouice of im- purity is eafily avoided by ufing an excefs of the antimonial ox- ide, which remaining undiffolved, occafions no error, and pre- vents the neceflity of throwing away, as the Dublin College d,i- rea, the cry dais which form on the filtering paper, if the folu- tion be faturated, Tartrite of antimony and potafs, or tartar emetic, cry flallizes in triangular pyramids, or in oaohedrons, more elongated than thofe of alum. It has a ftyptic metallic tafte. It is loluble in three times its weight of water at 212°, and in fifteen at 6o°.— As this fLtement of its folubility is very different from that of moft writers, from Bergmann to Fourcroy, who fay that it re- quires 80 parts of water at 6o°, asd fomewhat lefs than 40 of boil- ing watre, it is neceffdry to mention, that it was alcertained by careful experiment with the moft beiutiful cryftals of tartar emet- ic we ever faw, more than holt an inch in length, and perfeaiy free from the admixture of any foreign fait. The cryftals tfflo- refce flowly and (lightly in the air. The property of deliquefc- ing afcribed to them by Gottling, muft have arifen from the pre- fence of other falts, which is more probable, as he does not pre- pare his tartar emetic by cryftallizatrtJh, but by evaporating the folution to drynefs. The folution of tartar emetic flightly rendens tinaure of turnfol. It is decompofed by acids, alkalies, alkaline carbonates, fulphuretted hydrogen and its compounds vegetable juices, deco£tions and infufions, and many of tbe metals. Ac- cording toThenard, it confifts of tartrite of antimory ,54, tartrite .of potafs 34, water 8, and lofs 4; or oxide of antimony 38, tar- tarous acid 34, potafs 16, water and lofs 12 ; and by eftimation from theanalyfis of tartrite of potafs, and fupertartrite of potafs, by the fame chemift it appears, that to faturate 38 parts ot oxide of antimony, 70.4 of fupertartrite of potafs are neceffdry ; the whole of the fuperfluous acid being 16, combines with the oxide, while 34 of the tartrite of potafs combine with the tartrite of an- timony thus formed, and 20.4 of tartrite of potafs remain in folu- tion in the mother water. We have been thus particular in our account ot the prepara- tion and chemical properties of tartar emetic, becaufe it is not onlv of all the preparations of antimony the moft certain in its operation, but is almoft indifpenfable lor the fuccefsful praaice of medicine. In dofes of from one to three grains it operates as an emetic, and fomeiirres as a cathartic. In fmaller dofes, it excites naufea, and proves a powerful diaphoretic and expectorant. As an emet- ic it is chiefly given in the beginning of fevers and febrile dif- 436 Preparations and Compositions. [Part III. eafes, in chincough, and, in general, whenever we wifh to evacu- ate the ftomach quickly. When great debility is prefent, and in the advanced flagesof typhoid fever, its ufe is improper, and even fometimes fatal. As a diaphoretic it is given in fmall dofes of from an eighth to a quarter of a grain ; and as an expeaorant in dofes ftill fmaller. The only proper form for exhibiting it is in folution ; and as the intenfity of its aaion on the body is liable to variation, from differences in its own ftrength, and in the conftitution of the pa- tient, it fhould almoft always be given in divided dofes, at fhort intervals, if we wifh to excite vomiting ; and at longer intervals, if we only wifh it to aa on the fkin or lungs. VINUM TARTRITIS ANTIMONII ; olim, Vinum An- TIMONIALE. Edin. Wine of Tartrite of Antimony, formerly Antimonial Wine. Take of Tartrite of antimony, twentyfour grains ; Spanifh white wine, one pound. Mix them fo that the tartrite ot antimony may be diffolved. Vinum Tartari Stibiati. Dub. Wine of Antimoniated Tartar. Take of * Antimoniated tartar, ten grains ; Diftilled water, boiling hot, half an ounce ; Spanifh white wine, two ounces. Diffolve the antimoniated tartar in the water, and then add the wine. Vinum Antimonii Tartarisati. Lond. Wine of Tartarized Antimony. Take of Tartarized antimony, two fcruples ; Boiling diftilled water, two ounces ; Spanifh white wine, eight ounces. Diffolve the tartarized antimony in the boiling diftilled water, and add the wine. Vinum Antimonii. Lond. Wine of Antimony. Take of Vitrified antimony, in powder, one ounce ; Spanifh white wine, a pint and a half. Digeft them for twelve days, agitating them irequently, and drain through paper. Chap. V.] Of Antimony. 437 All thefe are folutions of tartrite of antimony and potafs in wine ; for, in the laft inftance, a portion of the glafs of antimony is diffolved by the fupertartrite of potafs contained in the wine ; and as the quantity of this is variable, fo alfo the quantity of oxide of antimony diffolved, varies ; and therefore the prepara- tion ought to be entirely rejeaed, fince its ftrength can never be known. It is alfo to be regretted, that the ftrength of the folu- tions of tartar emetic in wine, as prefcribed by the different Col- leges, is not uniform. According to the Edinburgh College, one ounce of the folution contains two grains of tartar emetic, while the fame quantity, according to the other Colleges, contains four grains. In its employment and effeas, the vinous folution ot tartar e- metic does not differ from one made with water, ANTIMONIUM CALC1NATUM. Lond. Calcined Antimony. Take of Antimony, powdered, eight ounces ; Nitre, powdered, two pounds. Mix them, and projea the mixture by degrees into a red hot cru- cible. Burn the white matter about half an hour ; and, when cold, powder it ; after which wafh it with diftilled water. On touching the ignited crucible, this mixture deflagrates with a lively white flame ; the antimony is oxidized to the maximum, the fulphur is acidified, and the nitre is decompofed and reduced to its bafe. The produa of this deflagration is a lemon colored, fcorified mafs, which, after being wafhed with water, leaves the greater part of the oxide of antimony united to about a fifth of its weight of potafs ; while the remainder of the oxide, com- bined with a much larger proportion of potafs, is diffolved in the water, along with the fulphate of potafs formed, and a fmall quan- tity of nitre which has efcaped decompofition. The oxide of an- timony obtained by this procefs contains about 0.32 oxygen, is fcarcely aaed upon by acids, and is capable of forming with the alkalies, cryftallizable compounds, enjoying a determinate degree of folubility. It may therefore be confidered as nearly approaching to the ftate of an acid ; and therefore the infoluble refiduum ot this procefs might be named Super antimonite of pot- afs, and the diffolved portion from its different proportions Anti- monite of potafs. This is a preparation of no very great aaivity. It formerly bore the name of Diaphoretic antimony, from its fuppofed effea ; but even that was doubted ; and fince the introduaion of James's powder into general ufe, it has not been much employed. It may be given in dofes from five grains to half a drachm. 438 Preparations and Compositions. [Part III. CHAP. VI. S 1 L V E R. N1TRAS ARGENTI; olim, Causticum Lunare. Edin. Argentum Nitratum. Dub. Nitrate of Silver. Nitrated Silver, formerly Lunar Cauflic. Take of Pureft filver, flatted into plates, and cut in pieces, four ounces; Diluted nitrous acid, eight ounces ; Diftilled water, tour ounces. Piffolve the filver in a phial with a gentle heat, and evaporate the folution to drynefs. Then put the mafs into a large crucible, and place it on the fire, which fhould at firft be gentle, and af- terward increafed by degrees till the mafs flows like oil; then pour it into iron pipes, previoufly heated and anointed with tallow. Laftly, keep in a glafs veffel well fhut, Argentum Nitrati/m. Lond. Nitrated Silver. Take of Silver, one ounce ; Diluted nitrous acrd, four ounces, Diffolve the filver in the diluted nitrous acid, in a glafs veffel, over warm fand ; then dry it by gently increafing the heat ; afterwards melt it in a crucible, taking care that the heat be not too great, and pour it into proper forms. The only difference between thefe formulas is in the propor- tion of acid employed, The Edinburgh and Dublin Colleges ufe equal weights of filver and acid. The London College ufes double the quantity of acid. The faa is, that nitrous acid is ca- pably of diffolving more than half its weight of filver, Therefore in the one cafe, a portion of filver will be left undiffolved ; and, in the other, there will be an excefs of acid, which, however, will be expelled by the heat neceffary to bring the fait to,a ftate of dry- nefs. During the folution the metal is oxidized by the decom- pofition of part of the acid, while the nitrous gas difengaged at firft diffolves in the acid, and gives it a green color, which, however, difappears when the heat is increafed fo as to expel the gas. The acid employed muft be very pure. If it contain, as the acid of commerce always does, fulphuric or muriatic acid, Chap. VI.] Of Silver. 439 thefe reaa upon the nitrate as foon as it is formed, and a white precipitate, confifting of fulphate and muriate of filver, falls to the bottom. * The method which the refiners employ for examining the pu- rity of their aquafortis (the name they give to dilute nitrous acid) and purifying it if neceffary, is to let fall into it a few drops of a folution of nitrate of filver already made : If the liquor remain clear, and grow not in the leaft turbid or whitifh, it is fit for ufe ; otherwife, they add a fmall quantity more of the folution, which immediately turns the whole of a milky white color ; the mix- ture being then fuffered to reft tor fome time, depofites a white fediment; from which it is cautioufly decanted, examined again, and, if neceffary, farther purified by a frefh addition of the folu- tion. It is neceffary to employ very pure water in this procefs, for the muriates and earthy falts which common water generally contain, precipitate part of the filver in the ftate of a muriate or oxide. If diftilled water be not ufed, the water fhould be added to the acid before it be tried and purified by the nitrate of filver. The filver flatted into thin plates, as directed in the fecond of the above proceffes, needs not be cut in pieces; the folution will go on the more fpeedily, if they are only turned round into fpiral circumvolutions, fo as to be conveniently got into the glafs, with care that the feveral furfaces do not touch each other. By this management, a greater extent of the furface is expofed to the ac- tion of the menftruum, than when the plates are cut in pieces and laid above each other. If the filver be alloyed with copper, the folution will have a permanent greenifh blue color, and acquire a bright blue on the addition of ammonia. If it contain gold, the gold is not diffolved, but is found at the bottom of the folution, in the form of a black or deep purple powder. The crucible ought to be of filver or porcelain ; as with the common crucibles, the lofs arifing from the nitrate of filver fink- ing into their fubftance is too great. It ought alfo to be large enough to hold five or fix times the quantity of the dry matter ; for it bubbles and fwells up greatly, fo as otherwife to be apt to run over. During this time, alfo, little drops are now and then fpirted up, whofe caufticity is increafed by -their heat, againft which the operator ought therefore t,o be on his guard. The fire muft be kept moderate till this ebulition ceafes, and till the mat- ter becomes confiftent in the heat that made it boil before : Then quickly increafe the fire till the matter flows thin at the bottom like oil, on which it is to be immediately poured into the mould ; for if the heat be continued after this, the nitrate of filver begins to be decompofed, and the filver is reduced. In want of a proper iron mould, one may be formed of temper- ed tobacco pipeclay, not too moift, by making in a lump of it 440 Preparations and Compositions. [Part III. with a fmooth (lick firft greafed, as many holes as there is occa- fion for ; pour the liquid matter into thefe cavities, and when con- gealed take it out by breaking the mould. Each piece is to be wiped clean from thegreafe, aud wrapt up in foft dry paper, not only to keep the air from aaing upon them, but likewife to pre-. vent their corroding or difcoloring the fingers in handling. Nitrate ot filver is cryftallizable. Its cryftals are brilliant plates, having a variable number of fides. Their tafte is auftere, and intenfely bitter. They are very foluble in water, but per- manent in the air, and not deliquefcent. They are decompofed by heat, light, phofphorus, charcoal, many metals, all the al- kalies and earths, fulphuric, muriatic, phofphoric and fluoric acids, and by the falts they form. When deprived of water, and melted according to the direaions of the colleges, it forms a black or dark gray colored mafs, which, when broken, appears to confift of radii, diverging from the centre. It is not deliquefcent when free from copper, which is feldom the cafe. It may, however, be prepared perfeaiy pure, even from a folution containing cop- per, by evaporating andcryftallizing it as long as it furnifhes firm tabular cryftals. Thefe are then to be wafhed with a little dif- tilled water, and melted with a gentle heat. The nitrate of cop- per remains in the mother water, and the filver which it contains may be precipitated with muriatic acid. A ftrong folution of nitrate of filver corrodes and decompofes animal fubftances ; in a more diluted ftate it (tains them of an in- delible black ; and for this purpofe it is fometimes applied to the hair. The fufed nitrate of filver is the ftrongeft and moft man- ageable cauftic we poffefs, and is employed to remove fungous excrefcences, callous edges, warts, ftriaures in urethra, and the like. It is alfo ufed to deftroy the venereal poifon in chancres, before it has aaed on the fyftem. A weak folution of it may be applied as a ftimulus to indolent ulcers, or injeaed into fiftulus fores. Notwithftanding its caufticity, it has been given internally. Boerhaave, Boyle, and others commend it highly in hydropic ca- fes. The former affures us, that made into pills with crumb of bread and a little fugar, and taken on an empty ftomach (fome warm water fweetened with honey, being drank immediately af- ter) it purges gently without griping, and brings away a large quantity of water, almoft without the patient's perceiving it ; that it kills worms, and cures many inveterate ulcerous diforders. He neverthelefs cautions againft ufing it too freely, or in too large a dofe ; and obferves that it always proves corrofive and weaken- ing to the ftomach. It has been more recently employed, and with fuccefs in epi- lepfy and angina peaoris. On account of its very great aaivity, each pill fhould not contain above one eighth or one fourth of a grain. Chap. VII.] Of Copper. 441 CHAP. VII. COPPER. /ERUGO PR^LPARATA. Dub. Prepared Verdigrife. Let the verdigrife be ground to powder, and the minute particles be feparated in the manner direaed for the preparation of craba claws. Lond. Verdigrife is to be prepared as other fubftances not foluble in wa- ter (page 41,5.) The intention of this procefs is merely to obtain the fub ace- tite of copper in the ftate of the moft minute mechanical divifion. SOLUTIO SULPHATIS CUPRI COMPOSITA; olim. Aqua Styptica. Edin. Compound Solution of Sulphate of Copper, formerly Styptic Water. Take of Sulphate of copper, Sulphate of alumina, each three ounces; Water, two pounds ; Diluted fulphuric acid, an ounce and a half. Boil the fulphates in the water to diffolve them, and then add the acid to the liquor filtered through paper. In this preparation, the fubftances diffolved in the water exeat no chemical aaion on each other, and the compofition wasprab- ably contrived from the falfe idea, that the fum of the powers iof fubftances having fimilar virtues, was increafed by mixing libera with each other. As might naturally be fuppofed, this Is a powerful iftyptlc, ami is fomewhat fimilar to the old aqua aluminofa Bateana of the for- mer pharmacopceias, fo much celebrated for flopping prof ufe ihae- morrhagies. Its chief ufe is tor flopping bleedings at the irwalfe ; and for this purpofe, cloths or doffils, fteeped in the liquor,, are to be applied to the part. 442 Preparations and Compositions. [Part III. AMMONIARETUM CUPRI ; olim, Cuprum Ammoni- acum. Edm. Ammoniaret of Copper, formerly Ammoniacal Copper, Take of Pureft fulphate of copper, two parts ; Carbonate ot ammonia, three parts. Rub them carefully together in a glafs mortar, Until after the1 effervefcence has entirely ceafed, they unite into a violet color- ed mafs, which muft be wrapped up in blotting paper, and firft dried on a chalk ftone, and afterwards by a gentle heat. The produd muft be kept in a glafs phial well clofed. Cuprum Ammonutum. Dub. Ammoniated Copper, Take of Vitriolated copper, half an ounce ; Mild volatile alkali, an ounce and a halfj Triturate them in a glafs mortar, until after the effervefcence ha* entirely ceafed, they unite into a mafs, which is to be wrapped up in bibuous paper, and dried upon a layer of gypfum, plac- ed in warm fand. It is afterwards to be kept in a phial, clofed with a glafs (topper. The difference between the proportions of the ingredients of this preparation, direaed by the two Colleges, is very ftriking. We know of no experiments to afcertain which of them is moft eorrefcl. It may feem ftrange that direaions are given fo particu- larly concerning the mann r of drying a mixture which is prepar- ed by rubbiriT two dry fubftances together. But fuch a phenom- enon is by no means uncommon, and arifes from the quantity of water of cryftallization contained in the ingredients being greater than what is required by the new compound formed : As foon, therefore, as the ingredients begin to aa upon each other, a quan- tity of water is fet at liberty, which renders the mafs moift. The nature ot this compound, and confequently the name which fhould be given it, are not yet fufficiently afcertained. Prepared according to the direaions of the Colleges, it evidently contains oxide of copper, ammonia, and fulphuric acid. It thefe fubftances be chemically combined, it fhould be denominated the Sulphate or Subfulphate of Copper and Ammonia. There is another way of preparing this fubftance, lefs economi- cal indeed, but more inftruaive to the ftudent of chemiftry, and jefs liable to variety in the produa. Into a faturated folution of fulphate of copper, drop a folution of carbonate of ammonia, or, what is better, water of ammonia, until the bluifh green precipi- tate, which is formed at firft, be rediffolved, and the liquor regain its tranfparency, and become of a beautiful deep blue color. Chap. VII.] Of Copperl 443 Concentrate this folution by evaporation, and mix it With about an equal quantity of alcohol, upon which the fait immediately precipitates in filky blue cryftals, which are to be colleaed by fil- tration, dried and kept in a phial, with a ground glafs ftopper. Ammonia, having a ftronger affinity for fulphuric acid than: oxide of copper has, feparates the oxide, which, being infoluble, is precipitated in the form of a bluifh green powder; But as this oxide itfelf is foluble in ammonia, it is rediffolved when more ammonia is added than is fufficient to faturate the acid. Inftead of obtaining the compound thus formed in a dry ftate by evapo- ration, which would partly decompofe it, advantage is taken of its infolubility in alcohol, which, from its more powerful affinity* feparates the water of the folution, and precipitates the cupreous fait in filky blue cryftals. When a fufficient quantity of alcohol has been employed, it merely abftraas the water of the folution, and precipitates the whole of the faline matter contained in it» which we are theretore difpofed to confider as a ternary compound of fulphuric acid, oxide ot copper, and ammonia. By drying; this precipitate undergoes fome alteration, for it is no longer to- tally foluble in water. As, however, the folution is eafily effea- ed by the addition of ammonia, it would appear that the alteration confifts in the decompofition of part of the ammonia. This preparation has fometimes been ferviceable in epilepfies ; but, from its frequent want of fuccefs, and the difagreeable con- fequences with which its ufe is fometimes attended^ it has not late- ly been much prefcribed. It is employed by beginning with dofeS of half a grain, twice a day ; and increafing them gradually to as much as the ftomach will bear. Dr. Culfen fometimes increafed the dofe to five grains. LIQUOR CUPRI AMMONIATI ; olim, Aqua Sappha- RINA. Dub. Liquor of Ammoniated Copper, formerly Sapphire Water. Take of Lime water, frefh made, eight ounces ; Sal ammoniac, two fcruples ; Verdigrife prepared, four grains. Mix and digeft them for twentyfour hours, then pour off the pure liquor. Aqua Cupri Ammoniati. Lond. Water of Ammoniated Copper; Take of Lime water, one pint; Sal ammoniac, one drachm. Let them ftand together, in a copper veffel, till the ammonia' feW faturated. E■ js 444 Preparations and Compositions. [Part III. In this preparation the lime water decompofes the muriate of ammonia and forms muriate of lime ; while the ammonia difen- gaged immediately reaas upon the oxide of copper contained in the verdigrife, and renders it foluble. But as the quantity ot lime employed is not fufficient to decompofe all the muriate of ammo- nia, the folution contains muriate of ammonia, muriate of lime, and ammoniaret of copper, forming probably a triple fait, with the acetous acid. The mode of preparing this folution, adopted by the London College, is. the remains of a fortuitous pharmacy, now juftly exploded by the other Colleges. This compound folution is applied externally for cleaning foul ulcers, and difpofing them to heal. It has been recommended al- fo for taking off fpecks and films from the eyes ; but when ufed with this intention, it ought to be diluted with fome pure water, as in the ftate of ftrength in which it is here ordered, it irritates and inflames the eyes confiderably. CHAP. Vill. IRON. FERRI LIMITURA PURIFICATA. Edin. Purified Filings of Iren. Place a fieve over the filings, and apply a magnet, fo that the fil- ings may be attraaed upwards through the fieve. This procefs does not fulfil the purpofe for which it is intend- ed. For the adhefion of a very fmall particle of iron renders brafs and other metals attraaable by the magnet. The filings of iron got from the fhops of different artificers, which are always mixed with folder and other metals, cannot be purified in this way, fo as to render them fit for internal ufe ; and indeed the on- ly way they can be obtained fufficiently pure is by filing a piece of pure iron with a clean file. FERRI OXIDUM NIGRUM PURIFICATUM; olim, Fer- ri SQUAMiE PURIFICATA. Edin. Purified Black Oxide of Iron, formerly Purified Scales of Iron. Let the fcales of the oxide ot iron, which are to be found at the foot of the blackfmith's anvil, be purified by the application of a magnet. For the magnet will attraa only the fmaller and Chap. VIII.] Of Ifdn. 445 purer fcales, and will leave thofe which are larger and lefs pure. Here the application of the magnet is ufeful, becaufe thefe fcales contain no foreign metal, but are mixed with earthy and ■ other impurities, whjch could be feparated in no other way.' CARBONAS FERRI ; olim, Ferri Rubigo. Edin. Carbonate of Iron, formerly Ruft of Iron. Moiften purified filings of iron frequently with water, that they may be converted into ruft, which is to be ground into an im- palpable powder. Ferri Rubigo. Lond. Ruft of Iron, Take of Iron filings, one pound. Expofe thefe to the air, often moiftening them with water until they be corroded into ruft ; then powder them in an iron mor- tar, and wafh over with diftilled water the very fine powder. Moiften the refiduum, which is not reduced by moderate triture to a powder, which may be eafily wafhed over, and expofe it again to the air ; and, laftly, after having ground it in a mortar, wafh it over. Dry the powder which is wafhed over. Dub. Take of Iron wire, any quantity. Cut it into pieces, which are to be moiftened frequently with wa- ter, and expofed to the air until they be corroded into ruft. Then powder them in an iron mortar, and by pouring water upon them, wafh over the fineft part of the powder, which is to be dried. The fame procefs may be frequently repeated. Iron is one of the moft eafily oxidized of the metals, It is capable of attraaing oxygen from the air, and of decompofing water even in the cold. By expofure at the fame time to air and moifture, it is very quickly oxidized* while at the fame time it abforbs carbonic acid, and is converted into a reddifh brown pul- verulent fubftance, well known by the name of ruft of iron. For medical ufe it is prepared as the other fubftances infoluble.in water. Apothecaries feldom make it themfelves, but obtain it from perfons who manufacture it in large quantities. It may be alfo prepared by precipitating the fulphate of iron with an alkaline carbonate; and as the procefs, though more/expenfive, is infinitely lefs tedious, and furnifhes a carbonate of iron of very great pu- C3" * 446 Preparations and Compositions] [Part III. rity, and in the ftate of the utmoft minutenefs, it has been admit- ted by the Edinburgh College. CARBONAS FERRI PR^-CIPITATUS. Edin. Precipitated Carbonate of Iron. Take of Sulphate of iron four ounces, Carbonate of foda five ounces, Water, ten pounds. Diffolve the fulphate in the water, and add the carbonate of foda, previoufly diffolved, in a fufficient quantity of water, and mix them thoroughly. Wafh the carbonate of iron, which is precipitated, with warm water, and afterwards dry it. On mixing the folutions of thefe falts together, there is an im- mediate mutual decompofition. Sulphate of foda is formed, which remains in folution, and carbonate of iron, which is precip- itated of a green color. The precipitate when firft formed, is the carbonate of black oxide of iron, or contains the iron in the ftate of black oxide, the ftate in which it exifts in the green ful- phate of iron ; but in the procefs of drying, it abforbs more ox- ygen, becomes of a red color, and is converted in«to the carbonate of red oxide of iron. As the precipitate is extremely light and bulky, it is not eafily feparated by allowing it tofubfide, and pour- ing off the clear liquor ; filtration fhould therefore be employed. The carbonate of foda is ufed in preference to the carbonate of potafs, on account ot the greater folubility of fulphate of foda than of fulphate of potafs, which renders the fubfequent ablution of the fait more eafy. The carbonate of iron is an axcellent and fafe chalybeate. It may be given in dofes from five grains to fixty ; but all chaly- beates anfwer better in fmall dofes, frequently repeated, than in large dofes. AQUA FERRI AERATI. Dub. Water of Ae'rated Iron. It is prepared in the fame manner as the water of fixed air (p. 374) by fufpending in the water half an ounce of iron wire. This is a very elegant chalybeate. The iron is in the ftate of black oxide, and is diffolved by means of carbonic acid. It was firft prepared by Bergmann, in imitation of the natural chaly- beate waters, and it forms an excellent fubftitute for them. Chap. VIII.] Of Iron. 447 SULPHAS FERRI. Edin. Sulphate of Iron. Take of Purified filings of iron, fix ounces ; Sulphuric acid, eight ounces; Water two pounds and a half. Mix them, and after the effervefcence ceafes, digeft the mixture for fome time upon warm fand ; then ftrain the liquor through paper, and after due evaporation fet it at reft to cryftallize. Ferrum Vitriolatum. ( Lond. Vitriolated Iron< Take of Filings of iron, Vitriolic acid, each eight ounces j Diftilled water, three pints. Mix them in a glafs veffel; and, when the effervefcence hasceaf- ed, place the mixture for fome time upon hot fand ; then pour off the liquor, ftraining it through paper ; and after due evap- oration, fet it afide to cryftallize, Ferrum Vitriolatum ; olim, Sal Martis, Dub. Vitriolated Iron, formerly Salt of Steel, Take of Iron wire, two ounces. Vitriolic acid, three ounces and a half j Water, two pounds. Mix the acid by degrees with the water in a glafs veffel, and grad- ually add the iron wire cut into pieces; digeft the mixture for fome time, and ftrain it through paper. Laftly, fet afide the liquor, after due evaporation, to cryftallize, by flow refrige- ration. Although the fulphate of iron may be purified by folution, filtration and cryftallization, fufficiently for many purpofes, yet it cannot be procured perfeaiy pure except by the direa union of fulphuric acid and iron ; and as it is of confequence that it fhould be pure when adminiftered internally, direaions for its prepara- tion have been given by all the Colleges. The differences which may be obferved in the proportions of the materials employed, is of little confequence, as fulphuric and iron unite only in one proportion. Iron fcarcely aas upon fulphuric acid unlefs affifted by heat. It then becomes oxidized, by abftraaing oxygen from a portion of the acid, and converting it into fulphurous acid gas or fulphur, and combines with the remainder of the acid. But it aas with PT3. 443 Preparations and Compositions. [Part III. great rapidity on diluted fulphuric acid ; in which cafe it is not oxidiz d at the expenfe of the acid itfelt, but by decompofing the water, and therefore the hydrogen of the water is feparaied in the form of gas. The aaion of the acid and iron upon each other of- ten ceafes before the acid is nearly faturated, and may be renew- ed by the addition of a little waur. The reafon is, that all the water which was not decompofed is employed to diffolve the ful- phate of iron formed. The properties and ufes of fulphate of iron have been already mentioned. SULPHAS FERRI EXSICCATUS. Edin. Dried Sulphate of Iron. Take of Sulphate of iron any quantity. Expofe it to the aaion ot a moderate heat in an unglazed earthen, veffel, until it become white and perfeaiy dry. The heat applied here muft not be fo great as to decompofe the fulphate of iron, but only to deprive it of its water of cryftal;li- _zation. OXIDUM FERRI RUBRUM. Edin. Red Oxide of Iron. Expofed dried fulphate of iron to an intenfe heat, until it is con- verted into a very red matter. By the violent heat applied in this preparation, the fulphate of iron is completely decompofed, and copious white tumes are ex- pelled. The iron is converted into the red oxide ; part of the fulphuric acid is therefore reduced to the ftate of fulphurous acid, arid the reft of the acid is expelled in a very concentrated ftate. This procefs was formerly employed in this country, and ftill is employed in Germany, for the preparation of fulphuric acid ; which, however, from the prefence of the fulphurous acid, was poffeffed of fome peculiar properties, fuch as emitting fumes and cryftallizing. The refiduum is compofed of red oxide of iron, combined with a little red fulphate of iron, which renders it de- liquefcent. To obtain the oxide perfeaiy pure, the refiduum muft therefore be wafhed with water, and dried quickly, to pre- vent the abforption of carbonic acid. T1NCTURA MURIATIS FERRI. Edin. Tinclure of Muriate of Iron. Take of The purified fcales of oxide of iron in powder, three ounces ; Chap. VIIL] Of Iron. 449 Muriatic acid about ten ounces, or as muchas may be fufficient to diffolve the powder. Digeft by a gentle heat, and after the powder is diffolved, add as much Alcohol as will make the whole quantity of liquor amount to two pounds and a half. Tinctura Ferri Muriati. Lond. Tinclure of Muriated Iron. Take of The ruft of iron, half a pound ; Muriatic acid, three pounds ; Reaified fpirit ot wine, three pints. Pour the muriatic acid on the ruft of iron in a glafs veffel ; and fhake the mixture now and then during three days. Set it by, that the feces may fubfide ; then pour off the liquor ; evapo- rate this to one pint, and, when cold, add to it the vinous fpirit. Dub, Take of Iron wire, half a pound ; Muriatic acid, three pounds ; Reaified fpirit of wine, three pounds. The direaions for combining thefe are exaaiy the fame with thofe of the London College. In making this preparation, each of the Colleges ufes iron in a different ftate ; the Dublin College, metallic iron ; the Edinburgh, the black oxide ; and the London College, the carbonate of the red oxide. There is no difference between the folutions of iron and of its black oxide ; becaufe the iron is converted into the ftate of black oxide by the decompofition of the water, before it is diffolved ; and accordingly, when iron is diffolved in muriatic acid, there is a difengagement of hydrogen gas ; whereas the black oxide is diffolved without any effervefcence. But muriatic acid is capable of combining either with the black or red oxides of iron, and forms with each, falts, having diftinaive properties. The red muriate of iron is not cryftallizable ; has a dark orange color ; is deliquefcent ; forms a brown red folution, having a very aftringent tafte ; and is foluble in alcohol. The green mu- riate is cryftallizable ; has little color ; is very foluble in water, forming a pale green folution ; and is infoluble in alcohol. But the aqueous folution of green muriate attraas oxygen fo rapidly from the atmofphere, that unlefs the accefs of the air be totally excluded, it is always partially converted into red muriate. The folutions of iron and of its black oxide, are accordingly found al- ways to contain a greater or lefs proportion of red muriate, and 450 Preparations and Compositions. [Part III. are therefore not uniform or conftant in their properties. Be- fides, as it is only the red muriate which is f luble in alcohol, it appears to us that it is better, according to the direaions of the London College, to ufe the red carbonate of iron, by which means we obtain an unmixed and permanent folution of the red muriate. Muriate of iron is alfo formed, when we diffolve the fuiphuret of iron in muriatic acid for the purpofe of procuring fulphuretted hydrogen gas. It is alfo the refiduum which remains in the retort after the fublimation of muriate of ammonia and iron. When well prepared, the alcoholic folution of muriate of iron has a yellowifh color,and very aftringent tafte. It is an excellent chalybeate, and may be given in dofes often or twenty drops twice or thrice a day, in any proper vehicle. MURIAS AMMONITE ET FERRI ; olim, Flores Mar- tiales. Edin. Muriate of Ammonia and Iron ; formerly Martial Flowers. Take of Red oxide of iron, wafhed and again dried ; Muriate of ammonia, equal weights ; Mix them thoroughly and fublime. Ferrum AmmoniacalS. Lond. Ammoniacal Iron. Take of Iron filings, one pound ; Sal ammoniac, two pounds. Mix and fublime. What remains at the bottom of the veffel mix by rubbing together with the fublimed matter, and again fub- lime. Although at a low temperature ammonia decompofes the mu- riate of iron, at a high temperature iron and its oxides decompofe muriate of ammonia. But as muriate ot ammonia is itfelf a vol- atile fait, great part of it efcapes undecompofed ; fo that the pro- dua is a mixture of muriate of ammonia with red muriate of iron. According to the formula of the Edinburgh College, the decom- pofition is effeaed by fimple affinity. As foon as the oxide of iron aas on the muriate of ammonia, the ammonia which is fepa- rated comes over; then as the heat increafes, undecompofed mu- riate of ammonia is fublimed ; which, as the procefs advances, is mixed with an increafing proportion of muriate of iron. In the procefs of the London College, the decompofition is more com- plex ; for the iron filings muft not only decompofe the muriate ot ammonia, but muft alfo decompofe ammonia itfelf, be- fore it can become fufficiently oxidized. In confequence of the latter decompofition, a confiderable quantity of hydrogen gas is Chap. VlII.] Of Iron. 451 produced. Both Colleges employ a much larger quantity of iron than is neceffary. According to the German pharmaceutifts, if the iron be equal to one fixttt nth of the muriate ot ammonia, it is fufficient. The new Pruflidn Difpenfatory direas one out ce of iron to be diffolved in two ounces ot muriatic acid, and one of nitrous acid ; this folution of red muriate of iron to be mixed with a watery folution of twelve ounces of muriate of ammonia, and the whole evaporated to drynefs ; and the dry mafs to be fub- limed in a wide necked retoit, with a heat increafed to rednefs. Whatever procefs be employed, the heat muft be applied as quickly as poffibb ; and the fublimed produa thoroughly mixed by trituration, and kept in well ftopt glafs veffels. It fhould have a deep orange color, and a finell refembling faffron, and fhould deliquefce in the air. This preparation is fuppofed to be highly aperient and attenu- ating ; though no otherwife fo than the reft of the chalybtates, or at moft only by virtue of the faline matter joined to the iron. It has been found of fervice in hyfterical and hypochondriacal cafes, and in diftempers proceeding from a laxity and weaknefs of the folids, as the rickets. From two or three grains to ten may be conveniently taken in the form of a bolus. TINCTURA FERRI AMMONIACALIS. Lond. Tintlure of Ammoniac al Iron. Take of Ammoniacal iron, four ounces ; Proof fpirit, one pint. Digeft and ftrain. This is merely a fpirituous folution of the preceding article, and is a much lefs elegant medicine than the fimple tincture of muriate of iron. FERRUM TARTARISATUM. Lond. Tartarized Iron. Take of Filings of iron, one pound ; Cryftals of tartar in powder, two pounds. Mix them with diftilled water into a thick mafs, which is to be expofed to the aaion of the air for eight days in a wide glafs veffel; then grind the matter, after being dried in a fand bath to a very minute powder. This is in faa a triple tartrite of iron and potafs, the excefs of acid in the fupertartrite of potafs being faturated by oxide of iron. The iron is oxidized during the firft part of the procefs, in which it is moiftened and expofed to the aaion of the air. 452 Preparations and Compositions. [Part III. Tartrite of potafs and iron may alfo be formed, by boiling a folution ot fupertartrite of potafs with iron, or, what is ftill bet- ter, with fome of the oxides of iron, until the excefs of acid be faturaied. The compound, according to Thenard, is very foluble, varies in color according to the ftate of the oxide ; cryftallizes in fmall needles, and has a chalybeate tafte. It is not precipitated by alkalies or alkaline carbonates. It is decompofed by ful- phuretted hydrogen and its compounds, and by gallic acid. The editors of Gren's Pharmacy fay, that a folution of iron in fuper- tartrite of potafs, furnifhes by evaporation greenifh fpathofe per- manent cryftals, difficultly foluble; which is furely a miftake ; at leaft it neither correfponds with Thenard's account, nor with the old name of this preparation, Mars Solubilis. The tartrite of iron and potafs may be given in the form of powder or bolus, in dofes of from ten to thirty grains. VINUM FERRI. Lond. Wine of Iron. Take of Iron filings, four ounces ; Spanifh white wine, four pints. Digeft for a month, often fhaking the veffel, and then ftrain. Vinum Ferratum ; olim, Vinum Chalybeatum. Dub. Ironated Wine, formerly Chalybeate Wine. Take of Iron wire cut in pieces, four ounces j White Rhenifh wine, four pints. Digeft tor a month, often fhaking the veffel, and then ftrain. This is merely a folution of the preceding article in wine ; for the iron is only diffolved in the wines by means of the fuper- tartrite of potafs it contains. The Rhenifh wine, direaed by the Dublin College, will therefore diffolve a larger quantity of iron than the Spanifh white wine of the London College. But a fo- lution of a known proportion of the preceding article in wine, will give a medicine of more equal powers, and may be made ex- tcmporaneoufly. 1 he'dofe is from a drachm to half an ounce, repeated twice Oj- thrice a day in chlorotic cafes. TINCTURA FERRI ACETATI. Dub. Tinclure of Acetated Iron. Take of Acetated vegetable alkali; Vitriolated iron, each one ounce. (Jhap. IX.] Of Iron. 453 Rub the acetated alkali and vitriolated iron together in a glafs, mortar, until the mafs deliquefces ; then add, during the tritu- rati j , the alcohol, and ftrain the folution. The acetite ot potafs, and fulphate of iron decompofe each other, and form acetite of iron, and fulphate ot potafs. But as the fulphate of potafs is not foluble in alcohol, the folution, after filtration, is an alcoholic folution of acetite of iron. The acetous acid is alfo capable of combining with both oxides of iron ; and as the iron in the fulphate, is in the ftate of black oxide, which has a ftrong attra6t;on for oxygen, it is probable that the acetite prepared in the way direcfed is a mixed acetite. It has an extremely ftyptic tafte, and is given in dofes of thirty or forty drops. CHAP. IX. M E R C U R T. HYDRARGYRUM PURIFICATUM. Dub. Purified Quickfilver. Take of Quickfilver, fix pounds. Draw off four pounds by flow diftillation. Hydrargyrus Purificatus. Lond. Purified Quickfilver. Take of Quickfilver, Iron filings, each four pounds. Rub them together, and diftil from an iron veffel. Edin. Take of Quickfilver, four parts, Filings of iron, one part. Rub them together, and diftil from an iron veffel. The quickfilver of commerce is often adulterated with lead, tin, or other metals, which renders it unfit for internal ufe, and for many preparations. It therefore becomes neceffary to purify it, and fortunately its comparatively great volatility fupplies us with an eafy mode. The Dublin College diftil it fimply without 454 Preparations and Compositions. [Part III. any addition ; but, left towards the end of the procefs the mercu- ry (hould elevate any impurities along with it, they draw off but t vo thirds. The principal objeaion to this procefs is the want of economy ; for although the remaining third may be ufed for fome purpofes, its value is very much depreciated. As iron has a much ftronger affinity for almoft all the fubftances with which q iickfilver may be adulterated, than quickfilver has, by adding iron filings we may draw off the whole quickfilver by diftillation, without any fear of the impurities rifing along with it. The Lon- don College add an equal weight of iron filings, but fo large a quantity caufes the fize of the diftilling apparatus to be unnecef- farily increafed. The Edinburgh College ufe one fourth, which is certainly enough. Glafs retorts are inadmiffible in this diftillation ; becaufe, when the mercury begins to boil, the concuffion is fo great, that they would certainly be broken. Iron retorts are the beft, although ftrong earthen ones may be alfo ufed. The receiver may be of the fame materials, or of glafs, if we wifh to infpea the progrefs of the operation ; but in this cafe we muft interpofe an adopter between the retort and receiver, and fill the receiver nearly full of water, that the mercury may not crack it by falling hot intojt. The retort employed fhould be fo large, that the quickfilver fhould not fill above one third of it. ACETIS HYDRARGYRI. Edin. Acetite of Quickfilver. Take of Purified quickfilver, three ounces ; Diluted nitrous acid, four ounces and a half, or a little more than may be required for diffolvi»g the mercury ; Acetite of potafs, three ounces; Boiling water, eight pounds. Mix the quickfilver with the diluted nitrous acid ; and after the effervefcence has ceafed, digeft if neceffary with a gentle heat, until the quickfilver be entirely diffolved. Then diffolve the acetite of potafs in the boiling water, and immediately to this folution, ftill hot, add the former, and mix them by agitation. Then fet the mixture afide to cryftallize. Place the cryftals in a funnel, and wafh them with cold diftilled water; and, laftly^ dry them with as gentle a heat as poffible. Chap. IX.] Of Mercury. 45$ Hydrargyrus Acetatus. Lond. Acetated Quickfilver. Take ot Purified quickfilver, Diluted nitrous acid, each half a pound ; Acetated kali, three ounces ; Tepid diftilled water, two pounds. Mix the quickfilver with the diluted nitrous acid in a glafs veffel, and digeft them for twentyfour hours with a gentle heat, that the quickfilver may be diffolved. Pour the nitrated quickfilver thus prepared into the acetated kali, previoufly diffolved in the tepid (900) water, that acetated quickfilver may be formed, which is to be firft wafhed with cold diftilled water, and afterwards dif- folved in a fufficient quantity of boiling diftilled water. Filter this folution through paper, and fet it afide to cryftallize; Hydrargyrum Acetatum. Dub. Acetated Quickfilver. Take of Purified quickfilver, Diluted nitrous acid, each half a pound ; Acetated vegetable alkali, three ounces ; Diftilled water, heated to about the ninetieth degree, two pounds and a half. Diffolve the mercury in the acid with a gentle heat. Mix the liquor, before cryftals foim in it by cooling, with the water in which the acetated vegetable alkali has been previoufly diffolv- ed. Wafh the precipitate with cold diftilled water, then pour upon it twentyfour pounds of diftilled water, and boil a little* Having removed the veffel from the fire, let it ftand at reft for about ten minutes; and, laftly, pour off from the fediment the clear liquor, and let the acetated quickfilver cryftallize in it by flow refrigeration. These proceffes are all fundamentally the fame. Nitrate of mercury is decompofed by acetite of potafs; and the produas are acetite of mercury and nitrate of potafs. The nitrate of potafs being much more foluble than the acetite of mercury, remains in folution after the latter is feparated by cryftallization. Mercury is capable of forming different combinations with nitrous acid, which poffefs each their charaaeriftic properties. When we em- ploy a fufficient quantity of acid to diffolve the mercury without the afliftance of heat, and to retain it in folution, there is always an excefs of acid; and therefore it is a folution of fupernitrate of mer- cury. If we evaporate this folution very gently, or if we employ 455 Preparations and Compositions. [Part lifi a larger proportion of mercury at firft. and affift the aaion of the acid by a gentle heat, we obtain nitrate of mercury cryftallized in various forms. But if we affift the aaion of the acid by boil- ing, a larger quantity of mercury is diffolved, and a fubnitrate is formed ; for, if we attempt to dilute the folution with water, a copious precipitate of fubnitrate of mercury immediately takes place, and the folution contains fupernitrate ot mercury. It is ftill unafcertained, whether thefe folutions differ only in the pro- portions of the nietal and acid, or in the degree of the oxidize- ment of the mercury. Fourcroy fays, that it is more oxidized in the fubnitrate, becaufe, during the converfion of the nitrate into the fubnitrate by the aaion of heat, nitrous gas is extricated. He alfo fays, that it forms a foluble fait when decompofed with muriatic acid. Chevenix, on the contrary, afferts that it is lefs oxidized, becaufe fupernitrate of mercury, prepared without heat, is. capable, when heated to ebuhtion, of diffolving an ad- ditional quantity of mercury without the formation of any ni- trous gas. Experiments alone can decide which of thefe chemifts has ftated the faa accurately ; but we are rather inclined to agree with the latter, as he was acquainted with Fourcroy's opinion, and criticifes it. We have mentioned thefe particulars with regard to the nitrates of mercury in this place, becaufe we have no op- portunity of doing it in a feparate article, and we fhall have oc- cafion to mention them frequently.* For making the acetite ot mercury, the nitrate is prepared with a very gentle heat, and with excefs of acid, that it may be retain- ed in perfea folution, and that there may be no poffibility of any admixture ot fubnitrate with the acetite formed. A larger pro- portion of acid is ufed by the Edinburgh College than by the other Colleges, but we believe it to be neceffary. In mixing the folutions; we muft be careful to pour the mercurial folution into the acetite of potafs, becaufe, by adopting the contrary procedure, fubnitrate of mercury will be precipitated undecompofed, if any of it be contained in the mercurial folution. For diffolving the * In our accounts of the quantity of cxigen, vfe have always followed the eft! ma- lion of thofe chemifts who have moft particularly delcribed any of thefe fa>ts. Thus, we have fometimes followed M- Fourcroy, fometimes Mr Chevenix ; but, to prevent the appearance of incoufiftency, it is neceffary to obferve, that thefe excellent chemifts differ , :emarkably in the quantities of oxygen they fuppofe to be in the fame oxide. M Fourcroy fuppofes that there are but three oxides ; the black, oxide, which he fays contains 004 of oxygen ; the red oxide, which contains 0.08 ; and another ftill more oxidized, but which cannot be obtained feparate. The grey, yellow and white oxides, he fuppofes to be lublalts, containing fome of thefe oxides. Mr. Chevenix has eftimated the oxide in the fubmuriate to contain 0.107 of oxygen ; and that in the muriate to contain ©. 1 5 of oxygen ; but we are hot to be milled by thefe numbers, to fuppofe that the oxide in the iubmuriate contains more oxygen than the red oxide does. On the contrary, it is extremely probable that it is the fame, or nearly the fame with Fourcroy's black oxide, and that the oxide in the muriate is the red oxide. Tbe numerical proportion of oxygen in thefe oxides muft therefore be ftill con- fidered as unafcertained. Chap. IX.] ~ Of Mercurf 45? acetite of potafs, the London and Dublin Colleges only ufe as much water as is capable of retaining the nitrate of potafs in fo- lution ; the acetite of mercury is therefore precipitated, and is purified by again diffolving it in boiling water, and cryftallizing it. This part of the procefs is fimplified|by the Edinburgh Col- lege, who ufe as much water for diffolving the acetite of potafs as is capable ot retaining, as long as it is hot, the acetite of'mer- cury in lolution, and of allowing it to cryftallize as it cools. In this way, therefore, it is procured at once fufficiently pure. The exficcation of the acetite ot mercury is an operation of great del- icacy ; for it is fo fpongy, that it retains the moifture with great obftinacy ; and it is decompofed fo eafily that heat can fcarcely be employed. It is beft dried by comprefling it between feveral folds ot bibulous paper. Acetite of mercury is fcarcely foluble in cold water, but dif- folves readily in boiling water. It generally cryftallizes in mi- caceous plates, and is extremely eafy of decompofition. It is fuppofed to be a mild preparation of mercury, and was the aaive ingredient of the celebrated Keyfer's pills. In folution it has alfo been recommended externally, to remove freckels and cutaneous eruptions. MURIAS HYDRARGYRI ; olim, Mercurius Sublima- tus Corrosivus. Edin. Muriate of Quickfilver, formerly Corrofive Sublimate. Hydrargyrus Muriatus. Lond. Muriated Quickfilver. Hydrargyrum Muriatum Corrosivum. Dub. Corrofive Muriated Quickfilver. Take of Purified quickfilver, two pounds ; Sulphuric acid, two pounds and a half ; Dried muriate of foda, four pounds. Boil the quickfilver with the fulphuric acid in a glafs veffel pla- ced in a fand bath, until the matter be dried. Mix the matter when cold in a glafs veffel, with the muriate of foda ; then fub- lime in a glafs cucurbit, with a heat gradually increafed.— Laftly, feparate the fublimed matter from the fcoriae. By boiling the quickfilver to drynefs with fulphuric acid, the metai is oxidized by the decompofition of part of the acid, and combines with the reft to form fubfulphate of quickfilver. In the fecond part of the procefs, this fubfulphate is decompofed by dried muriate of foda, muriate of quickfilver fublimes, and ful- phate of foda remains behind. In Holland it is rnanufaaured by % 458 Preparations and Compositions. [Tart. III. ftibj^aing to fublimation a mixture of dried fulphate of iron, ni- trate of potafs, muriate of foda, and quickfilver. In the former edi- tions of the hdinburgh Pharmacopoeia, the mercury was oxidized by boiling it to drynefs in nitrous acid, and then fublimed with muriate of foda and fulphate ol iron. Bergmann recommends the fublimation of fubnitrate ot mercury and muriate of foda. Muriafe of quickfilver cryftallizes by fublimation in prifmatic nredles, torming a white femitranfparent mafs. It is ponderous. Its tafle is acrid, ftyptic and durable. It is foluble in 20 parts of cold water, and in 2 at 2120. It is alfo foluble in 3.8 parts of al- cohol at 700, and in almoft an equal weight of boiling alcohol. It gives a green color to fyrup of violets. It is not altered by expofure to the air, and is fublimed unchanged by heat. It is not decompofed by any of the acids ; but is foluble, without al- teration, in the fulphuric, nitric, and muriatic acids. It is pre- cipitated by all the alkalies and earths, of an orange yellow color, which gradually changes to a brick red ; and by their carbonates, ot a permanent yellow color. Ammonia forms with it an infolu- ble, white, triple fait. It is alfo decompofed by feveral of the metals. It confifts, according to Mr. Chevenix, of Quickfilver 60.7 1 ^ ., r _ Oxygen 12.3} Oxiie of mercury 82 Muriatic acid 18 And the oxide therefore confifts of Quickfilver 8,5 Oxygen 15 100 100 Muriate of mercury is one of the moft violent poifons with which we are acquainted. Externally it aas as an elcharotic or a cauftic ; and in folution it is ufed for deftroying fungous flefh. and for removing herpetic eruptions; but even externally it muft be ufed with very great caution. It has however been recommend- ed to be given internally, by the refpeaable authorities of Boer- haave and Van Swieten ; and it is the aaive ingredent of all the empyrical antivenereal fyrups. Were it really capable of curing the venereal difeafe, or equal in efficacy to the common modes of adminiftering mercury, it would poffefs many advantages over them in other refpeas : But that it cannot be depended upon, is almoft demonftrated by its ufe as an antivenereal, being very much confined to the quacks, and by the teftimony of the moft expe- rienced praaitioners. Mr. Pearfon fays, that it will fometimes Chap. IX.] Of Mercury. 459 cure the primary fymptoms of fyphilis, efpecially if it produce confiderable forenefs of the gums, and the common effeas of mer- cury ; but that it will often tail in removing a chancre ; and where it has removed it, that the moft fteady perfeverance will not fe- cure the patient from a conftitutional affeaion. It is on fome oc- cafions, however, a ufeful auxiliary to a mercurial courfe, in quickly bringing the fyftem under the influence of mercury, and in fupporting its aaion after the ufe of fnaions, and is peculiar- ly efficacious in relieving venereal pains, in healing ulcers ot the1 throat, and in promoting the defquamation of eruptions. SUB MURIAS HYDRARGYRI; olim, CalomelaS; Edin. Submuriate of Quickfilver, formerly Calomel. Take of Muriate of quickfilver, ground to powder in a glafs mortar, four ounces ; Purified quickfilver, three ounces. Rub them together in a glafs mortar, with a little water, to pre- vent the acrid powder from rifing, until the mercury be extin- guifhed ; and having put the powder, after being dried, into art oblong phial, of which it fills only one third, fublime from warm fand. After the fublimation is finifhed, having broken the phial, throw away both the red matter found near the bot- tom of the phial, and the white matter near its neck, and fub- lime the reft of the mafs. Grind this into a very minute powder, which is laftly to be wafhed with boiling diftilled wa- ter. Hydrargyrum Muriatum Mite Sublimatum. Dub. Mild Sublimated Muriated Mercury. Take of Corrofive muriated mercury, one pound ; Purified quickfilver, nine ounces. Rub them together until the globules difappear, and fublime. Rub the fublimed matter with the refiduum,: and repeat the fub« limation. Laftly, wafh the fublimed matter with frequent af* fufions of boiling diftilled water. Calomelas. Lond. Calomel. Take of Muriated quickfilver, one pound ; Purified quickfilver, nine ounces. F E 460 Preparations and Compositions. [Part III. Rub them together, until the globules difappear and fublime; then rub the whole matter again together and fublime. Repeat the fublimation in the lame manner four times. Afterwards tri- turate the matter into a very fubtile powder, and wafh it by the affufion of boiling diflilled water. When quickfilver is triturated with muriate of quickfilver, it ruftraas from the oxidized quickfilver of the muriate a part of its oxygen, and the whole mafs affumes a blackiffi grey color. When this is expofed to a degree of heat fufficient to convert it into vapor, the aaion of the different portions of quickfilver up- on each other, and upon the muriatic acid, is much more com- plete ; and the whole is converted into a folid white'mafs, confift- ing of mercury in a ftate of lefs oxidizement, and combined with lefs acid than in the muriate. The trituration of the muriate of mercury is a very noxious operation, as it is almoft impoffible to prevent the finer particles from rifing and affeaing the operator's eyes and noftrils. To lef- fen this evil, the Edinburgh College diredt the addition ofa little water. In the fecond part of the procefs, when the heat is ap- plied, a fmall portion of quickfilver and undecompofed muriate firft arife, and condenfe themfelves in the higheft part or neck of the phial ; then the fubmuriate rifes, and, being lefs volatile, con- denfes in the upper half of the body, while a fmall quantity of quickfilver, in a ftate of confiderable oxidizement, remains fixed, or near the bottom. The Edinburgh College feparate the fubmu- riate from the other matters, and fublime it again. The other Colleges triturate the whole together again, andrefublime it, the Dublin College once, the London four times. As in the firft fub- limation, a portion of the quickfilver and of the muriate of quick- filver always arife undecompofed, a fecond fublimation is necef- fary, efpecially if we triturate the whole produas of tbe firft fub- limation together ; but any further repetition of the procefs is per- feaiy ufelefs. Left any portion of muriate fhould have efcaped decompofition, the fubmuriate muft be edulcorated with boiling diftilled water, until the water which comes off forms no precip- itate with alkalies. Subrnuriate of mercury is generally obtained in the form ofa white folid mafs ; but is capable of cryftallizing in tetrahedral prifms terminated by pyramids. It has no tafte, and is fcarcely foluble in water or in alcohol. It is lefs volatile than muriate of mercury. It is.bjackened by light, and becomes brown when tri- turated with lime water or the alkalies. It is converted by oxv- muriatic acid into muriate of quickfilver. According to Mr. Chenevix, It confifts of Chap. IX.) Of Mercury. 461 Quickfilver, 79 \0xide of quickfilver, 88.5 Oxygen, 9.5 / ^ ° Muriatic acid, 11.5 100 And its oxide contains, Quickfilver, 89.3 Oxygen, 10.7 100 By comparing this analyfis with that of the muriate of mercury; 54 parts of quickfilver feem in faa fufficient to convert 100 of the muriate into fubmuriate; but with Mr. Chenevix we think the excefs employed by the Colleges a ufeful precaution. The.fubmuriate of quickfilver is one of the beft mercurials we poffefs. By proper management it may be made to increafe, in a remarkable manner, almolt any of the fecretions or excretions. One grain mixed with fugar, andfnuffed up thenoftrils, is recom- mended as a powerful errhine in amaurofis. The fame mixture is blown into the eye, to remove fpecks from the cornea. Given in dofes of one grain morning and evening, or in larger dofes com- bined with opium, to prevent it from aaing as a purgative, it ex- cites ptyalifm. In larger dofes of five grains and upwards, it is ah excellent purgative. Combined with diuretics, it proves diuretic, and with fudorifics, fudorific. It is one of the preparations of mercury which is capable of cur- ing fyphilis in every form. It alfo produces very powerful and falutary effeas in obftruaions and chronic inflammations of the vifcera, efpecially of the liver ; and, in general, it is applicable to every cafe in which mercurials are indicated. SUB MURIAS HYDRARGYRI PR^ECIPITATUS, Edin. Precipitated Submuriate of Quickfilver. Take of Diluted nitrous acid, Purified quickfilver, each eight ounces; Muriate of foda, four ounces and a half ; Boiling water, eight pounds. Mix the quickfilver with the diluted nitrous acid, and towards the end of the effervefcence digeft with a gentle heat, frequently fhaking the veffel in the mean time. But it is neceffary to add more quickfilver to the acid than it is capable of diffolving, that a perfeaiy faturated folution may be obtained. Diffolve at the fame time the muriate of foda in the boiling wa- ter, and into this folution pour the other while ftill hot, and mix them quickly by agitation. Pour off the faline liquor after the precipitate has fubtided, and wafh the fubmuriate of quick- er * 462 Preparations and Compositions. [Part III. filver by repeated affufions of boiling water, which is to be poured off each time after the depofition of the fubmuriate, un- til the water come off taftelefs. Hydrargyrus Muriatus Mitis. Lond. Mild Muriated Quickfilver. Take of Purified quickfilver, Dilute nitrous acid, of each half a pound. Mix in a glafs veffel, and fet it afide until the quickfilver be dif- folved. Let them boil, that the nitrated quickfilver may be diffolved. Pour out the boiling liquor into a glafs veffel, con- taining another boiling liquor, confifting of Muriatic fait, four ounces ; Diftilled water, eight pints. After the powder has fubfided to the bottom of the veffel, pour off the clear fupernatant liquor, and wafh the powder which re- mains behind, till it becomes infipid, with frequent affufions of hot water ; then dry it on blotting paper with a gentle heat. Hydrargyrum Muriatum Mite Pr^ecipitatum. Dub. Precipitated Mild Muriated Quickfilver. Tajce of Purified quickfilver, fix ounces and a half; Diluted nitrous acid, fix ounces. Digeft in a glafs veffel with a moderate heat for fix hours, occa- fional ly agitating it. Towards the end ot the folution, increafe the heat fo as to make the liquor boil' for a little, which is then to be poured off from the quickfilver remaining undiffolved, ». and mixed with ten pounds of boiling water, in which four ounces of common fait have been previoufly diffolved. Wafh the powder which fubfides to the bottom with warm diftilled water, as long as the liquor decanted from it is rendered turbid from the addition of a few drops of mild ley. In the firft part of this procefs, a faturated folution of nitrate of quickfilver, with excefs of oxide, is formed. In the fecond, there is a mutual decompofition ot this nitrate, and of the muriate of foda ; nitrate of foda is formed, and muriate of quickfilver, with excefs of oxide. Mr. Chenevix thinks, that as water is capable of decompofing fubnitrate of quickfilver, a part of it is aaually de- compofed by the water holding the muriate of foda in folution, and that the precipitate prepared according the direaions of the colleges, is a mixture of fubmuriate and fubnitrate of quick- filver. To remedy this defea, he propofes either to employ a folution of quickfilver in nitrous acid made without heat, that is Chap. IX.] Of Mercury. 463 a folution of fupernitrate of mercury, or to add to the folwtion of muriate of foda a quantity of muriatic acid. To the latter pro- pofal there appears no objection ; but as he himfelt is of opinion that the fupernitrate of quickfilver contains the metal in a ftate of greater oxidizement, it furely cannot be ufed with propriety, for the preparation of a muriate, which fhould contain the quickfilver in a ftate of lefs oxidizemeut, and, in faa, the folution has been found to contain muiiateof quickfilver. Befides, we apprehend, that if a fufficient quantity ot muriate of foda be ufed (and no in- convenience can arife from ufing it in excefs) and if we be care- ful to pour the folution of the nitrate of mercury into that of the muriate of foda, that no fubnitrate will be contained in the pre- cipitate. Indeed, if we follow the direaions of M. Delkefkamp, and drop the folution of muriate of foda into thatof nitrate of mer- cury, a large proportion of the precipitate will confift of fubnitrate. When properly prepared, the fubmuriate obtained by precipi- tation fcarcely differs from that obtained by fublimation. Got- tling found.no other difference than that the precipitated fubmu- riate became grey, when triturated with lime water, whereas the fublimed fubmuriate becomes black. But he expofed to heat half an ounce of the precipitated fubmuiiate in a fubliming appa- ratus ; fcarcely a grain of a reddifh matter remained fixed ; and the fublimed matter now became black when triturated with lime- water, and differed in norefpea from fubmuriate prepared in the ordinary way by fublimation. It therefore would feem to be an improvement in the procefs, to fublime the fubmuriate after it is precipitated ; efpecially, as by that operation, it would be moft effeaually feparated from any fubnitrate which might be mixed with it. There is ftill another way of preparing the fubmuriate of mer- cury, without ufing corrofive fublimate, which muft be noticed. It was contrived by Hermbftaedt, and is recommended by Moench, with the confidence derived from experience, as the very beft procefs for preparing the fubmuriate of quickfilver. Take Pure quickfilver, feven ounces and a half ; Sulphuric acid four ounces ; Dried muriate of foda, five ounces and a half. Diftil in a glafs retort the fulphuric acid, with four ounces of the quickfilver, until they be converted into a dry white mafs, Triturate the fulphate of mercury thus formed, with the re- maining three ounces and a half of quickfilver, until the glo- bules difappear ; then add the muriate of foda ; mix them and fublime. As the produa of the firft fublimation ftill contains unoxidized quickfilver, it is to be again triturated and fublim- ed. The fublimate being wafhed, is now pure fubmuriate of quickfilver, and weighs about fix ounces. S3-3 464 Preparations and Compositions. [Part III. . The theory of this procefs is the fame with that of the forma- tion of the muriate of quickfilver. The difference between the two produas arifes from the proportion of quickfilver being great- er, and that of the muriate of foda employed being lefs. We are not prepared to ftate the comparative economy ot thefe three pro- ceffes defcribed, for preparing fubmuriate of quickfilver ; but ot the laft procefs, we may obferve, that according to Mr. Chene- vix's analyfis, feven ounces and a half of quickfilver fhould furnifh nine ounces and a half of fubmuriate of quickfilver ; fo that there is evidently a confiderable lofs, which muft be owing either to the formation of muriate of quickfilver, or of oxide of quick- filver. To diminifh this lofs, we might diffolve the refiduum of the firft fublimation, which is principally fulphate of foda, in the water with which the fublimate was wafhed, and precipitate the folution with carbonate of foda. We fhould thus regain the re- maining portion of the quickfilver in the ftate of brown carbonate, which might be applied to many purpofes. The fame thing might be praaifed with advantage on the wafhingsand refiduums ot fev- eral of the other preparations. CALX HYDRARGYRI ALBA. Lond. White Calx of Quickfilver. Sub Murias Hydrargyri et Ammonia, Sub muriate of Quickfilver and Ammonia. Take of Muriated quickfilver, Sal ammoniac, Water of prepared kali, each half a pound. Diffolve firft the fal ammoniac, afterwards the muriated quick- filver in diftilled water, and add to thefe the water of prepared kali. Wafh the powder until it become infipid. When to a folution of muriate of ammonia, there is added muriate of quickfilver, about thirty times more of the latter is dif- folved than the fame quantity of pure water is capable of diffolv- ing ; and there takes- place a confiderable increafe of tempera- ture. Now, as thefe faas fufficiently prove a reciprocal aaion of the two falts, and as there is no decompofition, it is evident that they muft have combined to form a triple fait \ efpecially as they cannot be again feparated either by fublimation or cryftalli- zation. This compound may therefore, with propriety, be term- ed Muriate of Mercury and Ammonia. It is the Sal Alembroth of the alchemifts. It is very foluble in water, and is fublimed by heat without decompofition. When to a folution of this fait we add a folution of an alkaline carbonate, there occurs a par- tial decompofition. The alkali combines with a portion of the muriatic acid ; and reduces the muriate of mercury and ammonia* Chap. IX.] Of Mercury. 4g5 to the ftate of a fubmuriate, which being infoluble, falls to the bottom of the folution. The fubmuriate of mercury and ammonia thus precipitated, has at firft an earthy and afterwards a metallic tafte. It is not-fo- luble in water. It is decompofed by heat ; furnifhing water, am- monia, and nitrogen gas, while 0.86 of fubmuriate of mercury remains behind. Sulphuric and nitric acid partially decompofe it, and convert it into muriate of mercury, and triple falts of nier- cury and ammonia. Muriatic acid diffolves it, and converts it in- to muriate ot quickfilver and ammonia. According to Four- croy's analyfis, it confifts of 81 oxide of mercury, 16 muriatic acid, 3 ammonia. 100 Therefore, if the analyfis of the different muriates be correa, there is an unneceffary want of economy in ufing equal parts of muriate of ammonia and muriate of mercury ; for by calculation at leaft, we fhould employ only one part of the former to eight of the latter. It is only ufed for ointments ; and its principal recommenda- tion is its fine white color. OXIDUM HYDRARGYRI CINEREUM. Edin. Afh colored Oxide of Quickfilver. Take of Purified quickfilver, four parts; Diluted nitrous acid, five parts ; Diftilled water, fifteen parts ; Water of carbonate of ammonia, a fufficient quantity. Diffolve the mercury in the nitrous acid ; then gradually add the diftilled water, and pour into the mixture as much water of the carbonate of ammonia as fhall be fufficient to precipitate the whole of the oxide of mercury, which is then to be wafhed with pure water and dried. Pulvis Hydrargyri Cinereus. Dub. Afh colored Powder of Quickfilver. Take of Quickfilver, two dunces; Diluted nitrous acid, two ounces and a half. Diffolve the quickfilver with a moderate heat, and dilute the li- quor with eight ounces of cold diftilled water ; then drop into it an ounce and a half ot the liquor of mild volatile alkali, pr as much as may be fufficient to precipitate the metal, which 83" 4 46(5 Preparations and Compositions. [Part. Ill, is to be wafhed with frequent affufions of warm water, and afterwards dried. Thc.se proceffes, which are effcntially the fame, are intended to furnifh a fubftitute tor the black oxide of quickfilver, on which the efficacy of the mercurials moft frequently employed, and moft certainly ufeful, depends. In thefe, the mercury is oxidized bv trituration, in contaa with the atmofphere ; but this operation is both fo tedious and troublefome, that it is often imperieaiy per- formed or affifted by improper means. In the proceffes we are now explaining, it was fuppofed that as $mmonia has a ftronger affinity for nitric acid than oxide of mercury has, it would feparate oxide of mercury from its folution in nitric acid ; and therefore, that the precipitate obtained was oxide of mercury fimilar to that formed by tituration. But fince the nature of the triple metalline falts has been better underftood, this has been difcovered to be an error, although the exaa mode of their action is not yet explained. The grey precipitate which is formed, may, fpeaking generally, be called a fubnitrate of mer- cury and ammonia ; for it confifts of oxide of mercury and am- monia, not faturated with nitric acid ; but even to occular infpec- tion it does not feem to be homogeneous ; and when it is digefted in acetous acid, it is partially diffolved, and the refiduum acquires a very pale or almoft white color. The portion diffolved feems to be black oxide, and the white refiduum to be pure fubnitrate of mercury and ammonia, which according to Fourcroy, cryftal- lizes in brilliant polyhedral cryftals, without fmell, of an ex- tremely ftyptic tafte, fcarcely foluble in water, is decompofed by heat, by the fulphuric and muriatic acids, and by lime, potafs, and foda, and confifts of 68.20 oxide ot mercury, 16 of ammonia, and, i*5.8oof nitric acid. According to thefe obfervations, this pre- paration ought not to be called the grey oxide of mercury, and is not identical with the black oxide of mercury, prepared by tri- turation. If, however, it anfwered the fame purpofes, the iden- tity would be of little confequence ; but from its never having been introduced into general ufe, although fo much more eafily prepared, we may prefume that it is not equal in point of effi- cacy. Black oxide of mercury may however be obtained, according to the direaion ot Saunders, by triturating with lime water, and fubfequent edulcoration, the fublimed fubmnriate of mercury, or rather the precipitated fubmuriate, as propofed by Gottling ; and that the decompofition may be more eafy and complete, we fhall venture to fuggeft, that for this preparation the latter fub- muriate fhould not be dried, but fhould be triturated with the lime water as foon as it is edulcorated. This fimple black oxide fertainly merits a fair trial. Chap. IX.] Of Mercury. 467 HYDRARGYRUS CUM CRETA. Lond. Ouickfilver with chalk. Take of Purified quickfilver, three ounces ; Prepared chalk, five ounces. Triturate them together until the globules difappear. Quicksilver has a ftrong affinity for oxygen, and abforbs it flowly from the atmofphere. But the combination may be con- fiderably accelerated bv agitation, and ftill more by triturating quickfilver with any fubftance which promotes its mechanical di- vifion, and thus increafes its furface. With this view, quickfil- ver is triturated with vifcid fubftances, as fats, honey, fvrup, &c. or with pulverulent fubftances, as the chalk in the prefent exam- ple. In this ftate of oxidizement, quickfilver contains about 0.040! oxygen according to Fourcroy, is foluble in acids without, the extrication of nitrous gas, and is eafily reduced by heat, and even by light. The black oxide is the mildeft, but at the fame time the moft efficacious of the preparations of mercury. Combined with chalk it is not in general ufe ; but in the form of the common mercurial pill and ointment, it is more employed than any other prepara- tions of the fame metal except calomel. HYDRARGYRUM CALCINATUM. Dub. Calcined Quickfilver. Take of Purified quickfilver, any quantity. Put it into an open glafs veffel, with a narrow mouth and wide bottom. Expofe this to about the fix hundreth degree ot heat, until the metal be converted into red fcales. Hydrargyrus Calcinatus. Lond. Calcined Quickfilver. Take of Purified quickfilver, one pound. Expofe the quickfilver in a flat bottomed glafs cucurbit, to an heat of about 600 degrees in a fand bath, till it concretes into the form of a red powder. This is an extremely tedious, and therefore expenfive opera- tion, becaufe mercury is incapable of abforbing from the atmof- phere the quantity oi oxygen neceffary to convert it into the red exide, except when in the ftate of vapor. But as the form ofa 468 Preparations and Compositions. [Part III. veffel, which will prevent the diflipation and lofs of the mercurial vapor, will at the fame time hinder the free accefs and frequent renewal of the air, the operation can only proceed flowly. The veffel moft advantageoufly employed, is a wide flatbottomed mat- rafs, with a very narrow, and almoft capillary neck. Only fo much mercury is introduced into it as will cover the bottom of the matrafs ; and the veffel is not inferted in the fand deeper than the mercury ftands within it. A degree of heat is then applied fuffi- cient to caufe a gentle ebullition in the mercury, which is thus alternately converted into vapor, and condenfed again in the up- per part of the veffel. While in the ftate of vapor, it abforbs the oxygen of the air contained in the veffel; by which means it is gradually changed into a black, and then into a red powder ; but a complete converfion into the latter ftate is not effeaed in lefs than feveral months. Red oxide of quickfilver thus prepared, oonfifts of fmall cryf- talline grains, of a deep red color, and very brilliant fparkling ap- pearance. By heat it may be fublimed in the form of a beautiful rubycolored vitrified fubftance. At a red heat it is decompofed, giving out oxygen gas, while the metal is revived, and is immedi- ately volatilized. It is foluble in feveral of the acids ; and during its folution it does not decompofe them or water. It is eafily ox- idized. It contains about o.i oxygen. It is not only an acrid fubftance, violently purgative and emetr ic, but even cauftic and poifonous. Its internal ufe is profcribed; but it is applied externally as an efcharotic, being previoufly tri- turated to a very fine powder ; or it is formed into a ftimulating ointment with unauous fubftances. OXIDUM HYDRARGYRI RUBRUM per ACIDUM NITRICUM ; olim, Mercurius PrjECipitatus Ruber. Edin. Red Oxide of Quickfilver by Nitric Acid, formerly Red Precipi. tated Mercury. Take of Purified, quickfilver, one pound ; Diluted nitrous acid, fixteen ounces. Diffolve the quickfilver, and evaporate the folution, with a gentle heat, to a dry white mafs ; which, after being ground into pow- der, is to be put into a glafs cucurbit, and to have a thick glaff- plate laid upon its furface. Then, having adapted a capital, and placed the veffel in a fandbath, apply a gradually increafed heat, until the matter be converted into very red fcales. (Chap. IX.] Of Mercury. 469 Hydrargyrus Nitratus Rublr. Lond. Red Nitrated Ouickfilver. Take of Purified quickfilver, Nitrous acid, of each one pound ; Muriatic acid, one drachm. Mix in a glafs veffel, and diffolve the quickfilver in a fandbath ; then raife the fire until the matter be converted into red cryf- tals. Hydrargyrum Sub Nitratum. Dub. Subnitrated Quickfilver. Take of Purified quickfilver, twenty ounces ; Diluted nitrous acid, twentyfive ounces. Mix them in a glafs veffel, and diffolve the quickfilver with a moderate heat ; then increafe the fire until the matter be con- verted into red fcales. In the firft part of thefe proceffes a fully faturated nitrate of mercury is formed. In the fecond part, the metal is oxidized to the maximum by the decompofition of the" acid. When a fuffi- cient heat is applied, the nitrate of mercury firft melts, then ex- hales nitric oxide gas, and changes its color fucceffively to yel- low, orange, and brilliant purple red. If well prepared, it fhould have a cryftalline fcaly appearance; and it is entirely volatile at a red heat, and foluble without any refiduum in nitrous acid. Ac- cording to Fourcroy it contains no nitrous acid, unlefs a fufficient heat has not been applied. It therefore differs in no refpe£t from the red oxide prepared by the aaion of heat alone, except in the facility of its preparation. In an economical point of view, it is evident that no more acid fhould be employed than what is abfolutely neceffary. If, there- tore, the proportion of the Dublin College be fufficient, that of the London muft be much too large. Theaddition of the fmall quantity of muriatic acid direaed by the London College, is faid to increafe the beauty of its appearance. How it fhould do fo, we are at a lofs to conceive ; for the muriatic acid having a ftronger affinity for mercury than nitrous acid has, will form with it a por- tion of muriate of mercury, which, being comparatively volatile, will be diffipated long before the nitrate of mercury is decompof- ed. The ufe of the muriatic acid is therefore to be rejeaed as being ufelefs and extravagant, and not from the fear expreffed by Mr. Accum, that a fubftance poifonous in itfelf fhould be render- ed more peifonous. 470 Preparations and Compositions. [Part III. SUB SULPHAS HYDRARGYRI FLAVUS ; olim, Tur- pethumMinerme. Edin. Yellow Sub fulphate of Quickfilver, formerly Turpeth Mineral. Take of Purified quickfilver, four ounces ; Sulphuric acid, fix ounces. Put them into a glafs cucurbit, and boil them in a fand bath to drynefs. Throw into boiling water the white matter, which is left in the bottom, after having reduced it to powder. A yel- low powder will immediately be produced, which muft be Ire- quently wafhed with warm water. Hydrargyrus Vitriolatus. Lond. Vitriolated Quickfilver. Take of Purified quickfilver, one pound; Vitriolic acid, fifteen ounces. Having mixed in a glafs veffel, h«at them by degrees until they unite, and dry the matter completely with a ftrong fire. This matter, on the affufion of a large quantity of hot diftilled water, will immediately become yellow, and fall to powder. Rub the powder with this -water in a glafs mortar. After the powder has fubfided, pour off the water, and wafh the matter with dif- tilled water till it becomes infipid. The aaion of fulphuric acid on mercury has been examin" ed with confiderable attention by Fourcroy. In the cold they have no aaion on each other, but on the application of heat, the ful- phuric acid begins to be decompofed, fulphurous acid gas is ex- tricated, and the metal is oxidized, and combines with the unde- compofed acid, forming with it a white faline mafs, covered with a colorlefs fluid. In this ftate it reddens vegetable blues, is acrid and corrofive, does not become yellow by the contaa of the air, and is not decompofed by water either warm or cold. It is there- fore fuperfulphate of quickfilver, and the proportion of the acid in excefs is variable. By wafhing the faline mafs repeatedly with fmall quantities of water, it is at laft rendered perfeaiy neutral. It no longer red- dens vegetable blues. It is white; it cryftallizes in plates, or fine prifmatic needles ; it is not very acrid, it is not decompofed ei- ther by cold or boiling water, but is foluble in ^oo parts of the former, and in about 250 of the latter. It is much more foluble in water acidulated with fulphuric acid. The fulphate of quick- filver confifts of 75 quickfilver, 8 oxygen, 12 fulphuric acid and 5 water. But if, inftead of removing the excefs of acid from the fuper- fulphate of quickfilver, by waffling it with water, we continue the Chap. IX.] Of Mercury. 471 aaion of the heat, according to the direaions of the Colleges, there is a copious evolution of the fulphurous acid gas, and the faline refiduum is converted into a white mafs, which therefore evidently contains both a larger proportion of mercury, and in a ftate of greater oxidizement, than the fait from which it was form- ed. But this white faline mafs is farther analyzed by theaffufion of hot water ; for one portion of it is diffolved, while the remain- der affumes the form of a beautiful yellow powder. The por- tion diffolved is faid to contain excefs ot acid. The yellow pow- der is, on the contrary a fubfulphate. The fubfulphate of quickfilver has a bright yellow color, a confiderably acrid tafte, is foluble in 2000 parts of cold water, is alfo foluble in fulphuric acid flightly diluted, and is decompofed by the nitric acid, and forms muriate of quickfilver with the mu- riatic acid, while the neutral fulphate forms fubmuriate. It oxi- dizes quickfilver, and is converted by trituration with it into a black powder. At a red heat it gives out oxygen gas, and the metal is revived. It confifts of 76 mercury, n oxygen, 10 ful- phuric acid, and 3 water. It is a ftrong emetic, and with this intention operates the moft powerfully of all the mercurials that can be fafely given inter- nally. Its aaion, however, is not confined to the primas viae ; it will fometimes excite a falivation, if a purgative be not taken foon after it. This medicine is ufed chiefly in virulent gonor- rhoeas, and other venereal cafes, where there is a great flux of hu- mors to the parts. Its chief ufe at prefent is in fwellings of the tefticle from a genereal affeaion ; and it feems not only to aa as a mercurial, but alfo, by the fevere vomiting it occafions, to per- form the office of a difcutient, by accelerating the motion of the blood in the parts affeaed. It is faid likewife to have been em- ployed with fuccefs, in robuft conftitutions, againft leprous dif- orders, and obftinate glandular obftruaions ; the dofe is from two grains to fix or eight. It may be given in dofes of a grain or two as an alternative and diaphoretic. Dr. Hope,fenior has found, that in dofes of one grain, with a little powder of liquorice root, it the moft convenient errhine he has had occafion to employ. This medicine was lately recommended as the moft effeaual prefervative againft the hydrophobia, On the whole, however, we confider it as a fuperfluous prepar- ation, whofe place may be more fafely fupplied by other mercu- rials of emetics. 472 • Preparations and Compositions. [Part IIL SULPHURETUM HYDRARGYRI NIGRUM ; olim, /£- thiops Mineralis. Edin. Black Sulphuret of Quickfilver, formerly AZthiops Mineral. Take ot Purified quickfilver, Sublimed fulphur, each equal weights. Grind them together in a glafs mortar with a glafs peftle, till the mercurial globules totally difappear. It is alfo prepared with twice the quantity of quickfilver. Hydrargyrus cum SulphuRe. Lond. Quickfilver with Sulphur. Hydrargyrum Sulphuratum Nigrum. Dub. Black Sulphurated Quickfilver. Take of Purified quickfilver, Flowers of fulphur. each one pound. Rub them together until the globules difappear. This procefs, fimple as it appears, is not, even in the prefent advanced ftate of chemiftry, perfeaiy underftood. It was for- merly imagined, that the quickfilver was merely mechanically di- vided, and intimately mixed with the fulphur. But that they are really chemically united, is indifputably proved by the infolubili- ty of the compound in nitrous acid. Fourcroy is of opinion, that during the trituration, the mercury abforbs oxygen, and is con- verted into the black oxide, and that in this ftate it is flightly combined with the fulphur. The editors of Gren alfo fuppofe it to be in the ftate of black oxide, but that it is combined with hy- droguretted fulphur ; and they direa a little water to be added du- ring the trituration, that by its decompofition it may furnifh the neceffary hydrogen. The black fuiphuret of quickfilver thus prepared by tritura- tion, has a pulverulent form, is infoluble in nitric acid, is totally foluble in a folution of potafs, and is precipitated unchanged from this folution, by acids. It is not altered by expofure to the air; and when heated in an open veffel, it emits fulphurous acid gas, acquires a dark violet color, and, laftly, fublimes in a brilliant red mafs, compofed of cryftalline needles. The combination of quickfilver with fulphur, may be much more fpeedily effeaed by the affiftance of heat, by pouring the mercury, previoufly heated, upon the fulphur in a ftate of fufion, and ftirring them until they cool, and form a confiftent mafs, which may be afterwards powdered. The fuiphuret prepared by fufion, Chap. IX.] Of Mermry. 473 differs however, from that prepared by trituration ; for it is not foluble in a folution of potafs, but is converted by long ebullition in it into the red fuiphuret, and it alfo reddens fpontaneoufly in courfe of time from the aaion of the air. Black fuiphuret of mercury may be alfo prepared in the humid way, as it is called by precipitation, or even by direa folution. According to Berthollet, mercury agitated with fulphuretted hy- droguret of ammonia, forms a black fuiphuret exaaiy refembling that prepared by trituration ; but if hydroguretted fuiphuret of ammonia be ufed, the blackprecipitate formed, gradually affumes a redcolor, and the folution contains fulphuretted hydroguret of ammonia. The fame phenomena take place with all the mercuri- al falts. As a medicine, black fuiphuret of quickfilver poffeffes no very confpicuous effeas. It is principallv ufed as an alternative in glandular affeaions, and in cutaneous difeafes. It has been com- monly given in dofes of from £ to 10 grains ; but even in dofesof feveral drachms, and continued for a confiderable length of time, it has fcarcely produced any fenfible effea. HYDRARGYRUM SULPHURATUM RUBRUM ; .olim, Cinnabaris Fact it i a. Lond. Dub. Red Sulphuretted Quickfilver, formerly Factitious Cinnabar. Take ot Quickfilver purified, forty ounces ; Sulphur, eight ounces. Mix the quickfilver with the melted fulphur, and if the mixture takes fire, extinguifh it by covering the* veffel ; afterwards re- duce the mafs to powder and fublime it. As foon as the mercury and fulphur begin to unite, a confider- able explofion frequently happens, and the mixture is very apt to take fire, efpecially if the procefs be fomewhat haftily conduaed. This accident the operator will have previous notice of, from the matter fwelling up, and growing fuddenly confiftent ; as foon as this happens, the veffel muft be immediately clofe covered. During the fublimation, care muft be had that the matter do» not rife into the neck of the veffel, fo as to block up and bur ft the glafs. To prevent this, a wide necked bolt head, or rather an oval earthen jar, coated, fhould be chofen for the fubliming veffel. If the former be employed, it will be convenient to introduce at times an iron wire, fomewhat heated, in order to be the better af- fured that the paffage is not blocking up ; the danger of which may be prevented by cautioufly raifing the veffel higher from the fire. If the ingredients were pure, no feces will remain. In fuch cafes the fublimation may be known to be over, by introducing a 474 Preparations and Compositions. [Part III. wire as before, and feeling therewith the bottom of the veffel, which will then be perfedtly fmooth ; If any roughnefs or in- equalities are perceived, either the mixture was impure, or the fublimation is not completed ; if the latter be the cafe, the wire will foon be covered over with the rifing cinnabar. The preparers of cinnabar in large quantity, employ earthen jars, which in fhape pretty much refemble an egg. Thefe are of different fizes, according to the quantity intended to be made at one fublimation, which fometimes amounts to two hundred weight. The jar is ufually coated from the fmall end almoft to the middle, to prevent its breaking from the vehemence or irregu- larity of the fire. The greater part, which is placed uppermoft, not being received within the furnace, has no occafion for this de- fence. The whole fecret, with regard to this procefs, is the ma- nagement of the fire, which fhould be fo flrong as to keep the mat- ter continually fubliming. to the upper part of the jar, without coming out at its mouth, which is covered with an iron plate. Care mould alfo be taken to put into the fubliming veffel only fmall quantities of the mixture at a time. When taken out of the fubliming veffels, the red fuiphuret of quickfilver is a brilliant cry ftalline mafs, and firft acquires its very rich colour when reduced to the form of a fine powder by trituration. It has neither fmell nor tafte, and is infoluble in water and in alcohol. In clofe veffels it fublimes entirely unchanged, but requires for this purpofe a pretty great degree of heat. It is not foluble in any acid, and is only decompofed by the nitro muriatic which defolves the quickfilver, and feparates the fulphur. It is not decompofed by boiling it with folutions of the alkalies, but is decompofed by melting it with potafs, foda, lime, iron, lead, copper, antimony, and feveral other metals. Prouft has proved it to confift of 85 quickfilver, and 14 or 14I fulphur, and that the quickfilver is not oxidized to a maximum, as had been falfely fup- pofed, but in its metallic ftate. His analyfis is confirmed by the other methods by which cinnabar mav be prepared. Thus, the black fuiphuret of quickfilver by fufion is converted into the red fuiphuret, by boiling it in a folution of potafs, which can only aa by diffolving the fulphuretted hydrogen and fuperfluous ful- phur. Submuriate, or fubfulphate of mercury, fublimed with ful- phur, furnifh red fuiphuret of mercury, and muriate, or fulphate, of mercury. Red fuiphuret ot quickfilver is fometimes ufed in fumigations againft venereal ulcers in the nofe, mouth, and throat. Haifa drachm of it burnt, the fume being imbibed with the breath, has occafioned a violent falivation. This effea is by no means owing to the medicine as a fuiphuret; for when fet on fire, it is no long- er fuch, but mercury refolved into vapor, and blended with the Chap. X.] Of Mercury. 475 fulphurous acid gas ; in which circumftances, this mineral has very powerful effeas. Mr. Pearfon, from his experiments on mercurial fumigation, concludes, that where checking the progrefs of the difeafe fuddenly is an object ot great moment, and where the body is covered with ulcers or large and numerous eruptions, and, in general, to ulcers, fungi, and excrefcences, the vapor of mercury is an application of great efficacy and utility ; but that it is apt to induce a ptyal- ifm rapidly, and great confequent debility, and that for the purpofe of fecuring theconftitutionagainfta relapfe, as a great quantity of mercury muft be introduced into the fyftem, by inunaion, as if no fumigation had been employed. CHAP. X. LEAD. ACETIS PLUMBI; olim, Saccharum Saturnu Edin. Acetite of Lead ; formerly Sugar of Lead. Take of White oxide of lead, any quantity ; Put it into a cucurbit, and pour upon it of Diftilled acetous acid ten times its weight* Let the mixture ftand upon warm fand till the acid becomes fweet* when it is to be poured off, and frefh acid added until it ceafe to become fweet. Then evaporate all the liquor, freed from impurities, in a glafs veffel, to the confiftence of thin honey, and fet it afide in a cold place, that cryftals may be formed, which are to be dried in the fhade. The remaining liquor is a- gain to be evaporated, that new cryftals may be formed ; and the evaporation is to be repeated until no more cryftals concrete. Cerussa Acetata. Lond. Acetated Cerufe. Take of Cerufe one pound ; Diftilled vinegar, one gallon and a half. Boil the cerufe with the vinegar until the vinegar is faturated j then filter through paper ; and after proper evaporation, fet i* afide to cryftallize. G G 476 Preparations and Compositions. [Part III. Dub. Take of * Cerufe, any quantity ; Diftilled vinegar, tentimes as much. Digeft in a glafs veffel, until the vinegar become fweel. Having poured this off, add more vinegar, until it ceafe to become fweet. Filter the liquor, and evaporate it flowly, fo that it may form cryftals, which are to be dried in the fhade. The acetite of lead is feldom prepared by the apothecary, as he can procure it at an infinitely cheaper rate from thofe who man- ufacture it in large quantities. The preparation of it, as direaed by the Colleges, is a cafe of fimple folution. The procefs fre- quently fails, from the oxide of lead employed being adulterated, with carbonate of lime, or fome other earthy fubftance. The ace. tous acid employed, fhould be as ftrong as can be procured ; for with a weak acid the produa of pure fait is fmall, and the quan- tity of mother water is increafed. The addition of a fmall quan- tity of alcohol to the folution, after it has been duly evaporated, is faid to improve the beauty of the cryftals. The mother water may alfo be made to furnifh pure cryftals, by adding to it a frefh portion of acetous acid ; for without that precaution, it furniflies only a very heavy, yellow, pulverulent mafs, in which there feems to be an excefs of oxide of lead. The manufaaure of acetite of lead is conduaed more economi- cally, when the oxide is diffolved in the acid at the fame time that it is prepared ; which is done by alternately expofing plates of lead to the vapour of acetous acid, and immerfing the plates thus cov- ered with oxide into the acid itfelf. Acetite of lead has a fweet ftyptic tafte. It has a white color, and cryftallizes in flat parallelopipeds, terminated by a wedge, or more commonly in fhining needles. It is foluble in water, and in alcohol ; efflorefces flightly in the air, and is decompofed by heat and light. It is alfo decompofed by the alkalies, and moft of the earths and acids. The proportions of its conftituents have not been afcertained. The internal ufe of acetite of lead, notwithftanding the enco- miums fome have been rafh enough to beftow upon it, is entirely to be rejeaed. It forms, however, a very valuable external ap- plication in external and phlegmonic inflammations, bruifes, and difeafes of the fkin. It is always applied in folution, either fim- ply, as to the eyes, or by means of cloths foaked in it, or mixed with bread crumb. A drachm, with five ounces of any diftilled water, forms a ftrong folution, and with ten ounces of water a weak folution. If common water be ufed, the addition of about a drachm of acetous acid will be neceffary to keep the lead in fo- lution. Chap. XL] Of Lead. 477 AQUA L1THARGYRI ACETATI. Lond. Liquor Lithargyri AcetatI ; olim,Extractum Sa- turni. Dub. Water of Acetated Litharge^ formerly Extrdcl of Lead. Take of Litharge, two pounds and four ounces ; Diftilled vinegar, one gallon. Mix, and boil to fix pints, conftantly ftirring ; then fet it afide. After the feces have fubfided, ftrain. Liquor Lithargyri Acetati Compositus. Dub. Aqua Lithargyri Acetati ComposTTa, Lond. Compound Liquor of Acetated Litharge. Take of Liquor of acetated litharge, a drachm ; Diftilled water, fourteen ounces (one pint, Lond.) Weaker fpirit of wine, a drachm. Mix the fpirit and liquor of acetated litharge, thert add the diftil- led water; These preparations do not differ from folutions erf the fame ftrength of acetite of lead, and are lefs proper, as their ftrength is apt to vary. The vitrified oxide of lead made ufe of in this in- ftance, is lefs eafily foluble, on account of its greater force of ag- gregation, than the white oxide, but, on the other hand, it is lefs liable to be adulterated. The addition of the diluted alcohol to the weak folution, is intended to prevent its decompofition, but it alfo renders it flightly ftimulant. CHAP. XL T I N. STANNI PULVIS. Lond. Powder of Tim Take of Tin, four ounces. Melt it, and take off the fcoriae. Then pour it into a clean iron veffel. Reduce it to powder, either by agitation or trituration ; and pafs the fine part of the powder through a hair fieve, (hfr 2 478 Preparations and Compositions. [Part III. Dub. Take of Tin, any quantity. Having melted it over the fire, agitate it while it is cooling, with an iron fpatula, until it be reduced to powder ; which is to be paffed when cold through a fieve. The College of Edinburgh do not give this preparation, infert- ing Limatura et Pulvis Stanni in their lift of the materia medica. It is often employed as a remedy againft worms, particularly the flat kinds, which too often elude the force of other medicines. The general dofe is from a fcruple to a drachm ; fome confine it to a few grains. But Dr. Alfton affures us in the Edinburgh effays, that its fuccefs chiefly depends on its being given in much larger quantities. He directs an ounce of the powder on an emp- ty ftomach mixed with four ounces of molaffes; next day, half an ounce; and the day following, half an ounce more ; after which, a cathartic is adminiftered. He fays the worms are ufually void- ed during the operation of the purge, but that pains of the ftomach occafioned by them are removed almoft immediately upon taking the firft dofe oi the tin. This praaice is fometimes fuccefsful in the expulfion of taeniae, but by too means fo frequently as Dr. Alfton's obfervations would lead us to Lope. Blane's powder, which certainly fucceeds fometimes in curing the diftempor in dogs, feems to be a fulphuretted oxide of tin. CHAP. XII. Z INC. OXIDUM ZINCI. Edi*. Oxide of Zinc. Let a large crucible be placed in a furnace filled with live coals, fo as to be fomewhat inclined towards its mouth ; and when the bottom of the crucible is moderately red, throw into it a fmall piece of zinc, about the weight of a drachm. The zinc foon inflames, and is at the fame time converted into white flakes, which are to be from time to time removed from the furtace of Chap. XII.] Of Zinc. 479 the metal with an iron fpatula, that the combuftion may be more complete ; and at laft, when the zinc ceafes to flame, the oxide of zinc is to be taken out of the crucible. Having put in another piece of zinc, the operation is to be repeated, and may be repeated as often as is neceffary. Laftly the oxide of zinc is to be prepared in the fame way as the carbonate ot lime. Zincum Calcinatum. Lond. Calcined Zinc. Take of Zinc, broken into pieces, eight ounces. Throw the zinc at feveral times into an ignited, large, deep, and inclined crucible ; placing over it another crucible, in fuch a manner that the air may have free accefs to the burning zinc. Take out the calx as foon as it appears, and pafs its white and lighter part through a fieve. Calx Zinci ; olim, Flores Zinci. Dub. Calx of Zinc, formerly Flowers of Zinc. Take of Zinc, broken into pieces, any quantity. Throw it at different times into a fufficiently deep crucible, heat- ed red hot, and placed with ks mouth inclined towards the mouth of the furnace. After each time any zinc is thrown in, cover the c/ucible with another inverted over it, but fo that the air may have accefs to the zinc. Preferve the white and very light calx for ufe. This is an inftance of fimple oxidizement. At a red heat, zinc attraas the oxygen of the atmofphere fo ftrongly, that it is quickly covered with a cruft of white oxide, which prevents the air from aaing on the metal below ; and therefore we are defired to operate only on fmall pieces at a time, and to place the cruci- ble fo that we may eafily takeout the oxide formed, and intro- duce frefh pieces of zinc. As foon as the cruft of oxide is brok- en or removed, the zinc inflames, and burns with a brilliant white orgreenifh blue flame, being at the fame time cuuverted into very light white flocculi. To fave thefe as much as pofiible, we are direcled to ufe a very deep and large crucible, and to cov- er it with an inverted crucible. But as we muft not cover it fo as to prevent the accefs of the air, it is doubtful whether the lat- ter precaution be of much fervice. The greater part of the zinc is, however, oxidized in the crucible, without being previoufly converted into vapor ; and as this portion ot the oxide is always mixed with particles of zinc, it is neceffary to feparate them by trituratipn and elutriation. £T 3 480 Preparations and Compositions. [Part II It The oxide thus obtained is of a pure white color, without fmell or tafte, infufible and fixed in the fire, infoluble in water or alco- hol, and entirely foluble in acids. The prefence of lead in it is deteaed by fulphuric acid, which forms in that cafe an infoluble fulphate of lead. The white ozide of zinc contains 82.15 zinc, and 17^85 oxygen. White oxide of zinc is applied externally as a detergent and exficcant remedy. With twice its weight of axunge, it forms ah excellent application to deep chops, or excoriated nipples. But befides being applied externally, it has alfo of late been ufed in- ternally. In dofes from one to feyen or eight grains, it has been much celebrated in the cure of epilepfy and feveral fpafmodic af- feaions; and there are fufficient teftimonies ot their good effeas, where tonic remedies in thofe affeaions are proper. CARBONAS ZINCI IMPURUS PR^fLPARATUS ; olim, Lapis Calaminaris PrjEparatus. Edin. Prepared Impure Carbonate of Zinc, formerly Prepared Calamine. The impure carbonate of zinc, after being roafted by thofe who make brafs, is prepared in the fame way as carbonate ot lime, (P-4»$0 Lapis Calaminaris Pr^eparatus. n Dub. Prepared Calamine. Reduce calcined calamine to powder, and feparate the impalpable parts in the fame manner that is direaed in the preparation of crabs claws (p. 41,5.) Lond. See the preparation of fubftances infoluble in water (p. 41,5.) As this oxide of zinc is intended for external application, and often to parts very eafily irritated, too much pains cannot be be- ■ftowed in reducing it to a fine powder. OXIDUM ZINCI IMPURUM PR^EPARATUM; olim, TUTIA PRvEPARATA. Edin. Prepared Impure Oxide of Zinc, formerly Prepared Tutty. It is prepared as carbonate of lime (p. 415.) Tutia Pr/eparata. Lond. Prepared Tutty. §ee the preparation of fubftances infoluble in water (p. 415.) This oxide is alfo prepared for external ufe only. Chap. XII.] Of Zinc. 481 SULPHAS ZINCI. Edin. Sulphate of Zinc. Take of Zinc, cut into fmall pieces, three ounces ; Sulphuric acid, five ounces, Water, twenty ounces. Mix them, and when the effervefcence is finifhed, digeft the mix- ture for a little on hot fand ; then ftrain the decanted liquor through paper, and after proper evaporation fet it apart, that it may cryftallize, Zincum Vitriolatum. Lond. Dub. Vitriolated Zinc. Take of White vitriol, one pound ; Vitriolic acid, one drachm ; * Boiling diftilled water, three pints. Mix and filter through paper. After proper evaporation, fet it afide in a cold place to cryftallize. The fulphate of zinc of commerce is never pure, but always contains iron, copper, and a little lead. From the mode of its preparation, there is alfo a deficiency of acid and water of cryftal- lization. The means direaed for purifying it by the London and Dublin Colleges will fupply thefe, but do not feparate the foreign metals, except perhaps the lead. If, therefore, a pure fulphate of zinc be wanted, we may, according to the direaions of the Edin- burgh College, diffolve pure zinc in pure fulphuric acid ; but we believe this procefs is very rarely praaifed, efpecially as the com- mon fulphate of zinc may be fufficiently purifi«d by expofing it in folution to the air, by which means red oxide of iron is pre- cipitated, and by digefting it upon pure zinc, which precipitates the other metals. Sulphate of zinc cryftallizes in tetrahedral prifms terminated by pyramids. It has a metallic, ftyptic'tafte ; efflorefces flowly when expofed to the air. It is foluble in 2.5 parts of water at 6o°, and in much lefs boiling water. It is nos foluble in alcohol. It is decompofed by the alkalies and earths, hydroguretted ful- phurets, and fulphuretted hydrogurets. It confifts of 20 oxide of zinc, 40 acid, and 40 water of cryftallization. Sulphate of zinc, in dofes from ten grains to half a drachm, operates almoft inftantly as an emetic, and is at the fame time perfeaiy fafe. It is therefore given, when immediate vomiting is required, as in cafes where poifon has been fwallowed. By employing it internally, in fmaller dofes, it aas as a tonic ; and, fome think it in every cafe preferable to the oxides zinci. £T 4 482 Preparations and Compositions. [Part III. Externally it is ufed as a ftyptic application to flop haemorrha- gies ; diminifh increafed difcharges, as gonorrhoea ; and to cure external inflammations arifing from debility and relaxation of the blood veffels, as in fome cafes of ophthalmia. SOLUTIO SULPHATIS ZINCI. Edin. Solution of Sulphate of Zinc. Take of Sulphate of zinc, fixteen grains; Water, eight ounces ; Diluted fulpjuiric acid, fixteen drops. piffolve the fulphate of zinc in the wate»; then, having added the acid, filter through paper. The acid is here added to diffolve the excefs of oxide of zinc, which the common fulphate often contains. This folution is of a ftrength proper for injeaing into the urethra in gonorrhoea, or applying to the eyes in chronic ophthalmia. AQUA ZINCI V1TRIOLATI cum CAMPHORA. Lond. Water of Vitriolated £inc with Camphor. Take of Vitriolated zinc, half an ounce; Camphorated fpirit, half an ounce, by meafure ; Boiling water, two pints. Mix, and filter through paper. It is ufed externally as a lotion for fome ulcers, particularly thofe in which it is neceffary to reftrain a great difcharge. It is alfo not unfrequently employed as a collyrium in fome cafes of ophthalmia, where a large difcharge of watery fluid takes place from the eyes with but little inflammation ; but when it is to be applied to this tender organ, it ought firft, at leaft, to be diluted, by the addition of more water. AQUA ALUMINIS COMPOSITA. Lond. Compound Alum Water. Take of Alum, Vitriolated zinc, of each half an ounce; Boiling diftilled water, two pints. four the water on the falts in a glafs veffel, and ftrain. This water was long known in our fhops, under the title of Aqua aluminofa Bateana. Chap. XIII.] Of Zinc. 483 It is ufed for cleanfing and healing ulcers and wounds ; and for removing cutaneous eruptions, the part being bathed with it hot three or four times a day. It is fometimes likewife employed as a collyrium ; and as an injeaion in gonorrhoea and fluoralbus, when not accompanied with virulence. SOLUTIO ACETIT1S ZINCI. Edin. Solution of Acetite of Zinc. Take ot Sulphate of zinc, a drachm ; Diftilled water, ten ounces. Diffolve. Take of Acetite of lead, four fcruples ; Diftilled water, ten ounces. Diffolve. Mix the fqlutions ; let them ftand at reft a little, and then filter the liquor. This is a cafe of double eleaive attraaion, the lead combining and forming an infoluble compound with the fulphuric acid, while the zinc unites with the acetous acid, and remains in folution. The acetite of zinc may be obtained by evaporation in talcy cryftals. It is foluble in water, and is decompofed by heat. It is not poifonous. When cryftallized acetite of lead and fulphate of zinc are tritu- rated together, the mixture prefently becomes moift, which is owing to the new compounds combining with lefs water of cryf- ftallization than the original falts, by which means a portion of the water is difengaged in its fluid form. The folution ©f acetite of zinc is with many praaitioners de- servedly much efteemed as an aftringent collyrium, and injeaion, CHAP. XIII. ALCOHOL, ETHER, and ETHERIAL SPIRITS, ALCOHOL. Lond. Ardent Spirit, Take ot Reaified fpirit of wine, one gallon, 484 Preparations and Compositions. [Part III. Prepared kali, made hot, one pound and a half ; Pure kali, one ounce. Mix the vinous fpirit with the pure kali, and afterwards add one pound of the hot prepared kali ; fhake them, and digeft for twentyfour hours. Pour off the fpirit, to which add the reft of the prepared kali, and diftil in a water bath. It is to be kept in a veffel well flopped. The kali fhould be heated to 3000 Fahrenheit. The fpecific gravity of the alcohol is to that of diftilled water as 815 to loco. Dub. Take of Reaified fpirit of wine, five pounds ; Pearlafhes, dried over the fire, and ftill warm, one pound ; Cauftic vegetable alkali, in powder, one ounce. Mix the fpirit and the cauftic alkali ; add the pearlafhes, previ- oufly reduced to powder, and digeft the mixture for three days, frequently agitating it ; then pour off the fpirit, and diftil over three pounds with a moderate heat. The fpecific gravity of this fpirit is to that of diftilled water as 820 to 1000. The theory of thefe proceffes has been already explained, fp. 129) and alfo the fuperiority of muriate of lime over carbo- nate ot potafs for feparating the laft portions of water from alco- hol. The potafs is ufed by the London and Dublin Colleges in fuch fmall quantity that it can have little effea ; when added in confiderable quantity, it aas upon the alcohol itfelf, and decom- pofes it. The Edinburgh College give no direaions for the prep- aration of a-perfeaiy pure alcohol, as it is never ufed in pharma- cy ; but it is perhaps to be regretted, that they have given the tu tie of alcohol to a liquid which is not the alcohol of chemifts. ./ETHER SULPHURICUS. Edin. Sulphuric Ether. Take of *• Sulphuric acid, Alcohol, each thirtytwo ounces. Pour the fpirit into a glafs retort fit for fuftaining a fudden heat, and add to it the acid in an uninterrupted ftream. Mix them by degrees, fhaking them moderately and frequently ; this done, inftantly diftil from fand previoufly heated for the purpofe, in- to a receiver kept cool with water or fnow. But the heat is to be fo managed, that the liquor fhall boil as foon as poffible, and continue to boil till fixteen ounces are drawn off; then let »he retort be removed from the fand. Chap. XIII.] Of Alcoholic 4.85 To the diftilled liquer add two drachms of potafs ; then diftil from a very high retort, with a very gentle heat, into a cool receiver, until ten ounces have been drawn off. If fixteen ounces of alcohol be poured upon the acid remaining in the retort after the firft diftillation, and the diftillation be re- peated, more ether will be obtained ; and this may be repeated feverd times. £ther Vitriolicus. Lond. Vitriolic Ether. Take of The fpirit of vitriolic ether, two pounds by weight ; Water of pure kali, one ounce by meafure. Shake them together, and diftil, with a gentle heat, fourtean oun- ces by meafure. iETHER Vitriolicus. Dub. Vitriolic Ether. Take of Vitriolic etherial liquor, fixteen ounces ; Cauftic vegetable alkali, in powder, two drachms. Mix them, and diftil with a gentle heat ten ounces from a very high retort into a cooled receiver. ^THER SULPHURICUS cum ALCOHOLE. Edin. Sulphuric Ether with Alcohol. Take of Sulphuric ether, one part ; Alcohol, two parts. Mix them. Spiritus ^Etheris Vitriolici, Lond. Spirit of Vitriolic Ether. Take of Reaified fpirit of wine, Vitriolic acid, each one pound. Pour the acid gradually upon the fpirit, and mix the*n by fhaking ; then diftil with a gentle heat, from a retort into a tubulated re- ceiver, to which another recipient is fitted, the fpirit ot vitrio- lic ether till fulphureous vapours begin to rife. If you apply another receiver, and continue the diftillatien, a ' little oil of wine will be obtained, which is to be preferved for ufe. 486 Preparations and Compositions. [Part III. Liquor ^Ethereus Vitriolicus. Dub. Vitriolic Etherial Liquor. Take of Reaified fpirit of wine, Sulphuric acid, each thirtytwo ounces. Put the fpirit into a glafs retort, capable of fupporting a fudden heat, and pour upon it the acid in a continued ftream. Mix them gradually, and having placed the retort in fand previoufly heated, diftil the liquor into a cool receiver. But the heat is to be fo regulated, that the mixture may boil as foon as poffi- ble ; and the retort is to be removed from the fand when fix- teen ounces have come over. OLEUM VINE Lond. Oil of Wine. Take of A'-okol, Vitriolic acid, of each one pint. Mix them by degrees, and diftil; taking care that no black froth pafs into the receiver. Separate the oily part of the diftilled liquor from the volatile vitriolic acid. To the oily part add as much waterof pure kali as is fufficient to correft the fulphureous fmell; then diftil off the tittle ether with a gentle heat. The oil of wine will remain in the retort, fwimming on the watery liquor ; from which it is to be feparated. 3PIRITUS iETHERIS VITRIOLICI COMPOSITUS. 1 Lond. Compound Spirit of Vitriolic Ether, Take of Spirit of vitriolic ether, two pounds; Oil of wine, three drachms. Mix them. UQUOR ^STHEREUS OLEOSUS ; olim, Liquor Hoff- manni Anodynus. Dub. Oily Etherial Liquor, formerly Anodyne Liquor of Hoffmann. Take what remains in the retort after the diftillation of the vitri- olic ether. Diftil to one half with a moderate heat. The produas arifing from the decompofition of alcohol by the aaion of the acids are extremely curious and interefting. The theory of their formation was not underftood until lately, when it was admirably explained by Fourcroy and Vauqueti», who fhew- Chap. XIII.] Of'Alcohol, be. 487 ed that the acid remains unchanged, and that the alcohol is con- verted into ether, water and charcoal. The moft convenient way of mixing the ingredients, is to put the alcohol into the retort firft, and, with a long tubed funnel, reaching down to the bottom of the retort, to pour in the acid. By cautious agitation, the two fluids unite, and heat is produced, which may be taken advantage of, in the diftillation, if we have a fandbath previoufly heated to the fame degree, to fet the retort into immediately after the mixture is completed ; nor is there ahy occafion for a tubulated receiver, it we immerfe the ordinary re- ceiver, which ought to be large in water, or bury it in broken ice. The dUlillation fhould be performed with an equal and very gentle heat. The junaure of the retort and recipient is to be luted with a pafte made of linfeed meal, and further fecured by a piece of wet bladder. Immediately on mixing the acid with the alcohol, there is a con- fiderable increafe of temperature, and a flight difengagement of alcohol, fomewhat altered, and having ah aromatic odor. On placing the retort in the fand bath, a portion of pure alcohol firft cornea over; and when the mixture in the retort boils, the ether rifes, and is condenfed in thin, broad, ftraight ftreaks, having the appearanceofo.il. Until the liquor which paffes over into the receiver amounts to about half, or fomewhat more than half, of the alcohol operated on, it confifts almoft entirely of alcohol and ether, and there has been no produaion of any permanently elaf- tic fluid ; but now the produaion of ether ceafes ; the fulphuria acid is decompofed ; and fulphureous vapors begin to arife, which condenfe in irregular ftreaks, or in drops; we muft therefore ei- ther put a flop to the procefs, or change the receiver. In. the lat- ter cafe the produas, are fulphurous acid, acetous acid, water, and oil of wine, as it was called, accompanied towards the end by a peculiar fpecies of carburetted hydrogen gas, called by the Dutch chemifts Olefiant gas ; becaufe, when mixed with oxygenized muriatic acid, it forms oilT' At laft the matter in the retort, which has now become thick and black, fwells up, and prevents us from carrying the procefs further. If we flop the procefs bffore the fulphureous vapors arife, the whole acid diluted with a proportion of wafer, and mixed with charcoal, remains in the retort; but if we aliow the procefs to go on, there is a continual decompofition of the acid, which is there- fore diminiffied in quantity. In either cafe, according to Prouft, the fulphuric acid may be obtained from the black refiduum in the retort, by diluting it with twice its weight of water, filtering it through linen, and evaporating it till it acquire the fpecific grav- ity 1.84, then adding about one fiv'e hundredth part of nitrate of potafs, and continuing ths evaporation until the acid become per- 4S£ Preparations and Compositions. [Part. Hf feaiy colorlefs, and acquire the fpecific gravity of 1.86. The re- fiduum, however, may be more advantageoufly preferved, as the Edinburgh College direa, for preparing more ether, by repeating the procefs repeatedly with frefh quantities of alcohol. Prouft indeed denies that this refiduum is capable of converting more al- cohol into ether ; but that excellent chemift has fomehow fallen into error, for it is a faa, that was known in the time of that no lefs excellent chemift Dr. Lewis, and inferted in his firft edition of this Difpenfatory, publifhed in I753, and not a recent difcov- ery of Citizen Cadet, as Fourcroy would lead us to believe. If farther confirmation be wanted, we fhall inftance Gottling, wbd fays, that from three or four pounds ot this refiduum, he has pre- pared 60 or 70 pounds ot the fpirit of vitriolic ether, and more than twelve pounds of vitriolic ether, without reaifying the re- fiduum, or allowing the fulphureous vapor to evaporate. The ether may be feparated from the alcohol and fulphureous acid, with which it is always mixed, by rediftilling it with a very gen- tle heat, after mixing it with potafs, or rather lime, which com- bine with the acid, or with black oxide of manganefe, which con- verts the fulphureous into fulphuric acid, and thus deprives it of its volatility. The chemical properties of ether have been already noticed: (§ 231.J Asa medicine taken internally, it is an excellent antif- pafmodic, cordial and ftimulant. In catarrhal and afthmatic com- plaints, its vapor is inhaled with advantage, by holding in the mouth a piece of fugar, on which ether has been dropped. It is given as a cordial in naufea, and in febrile difeafes of the typhoid type ; as an antifpafmodic in hyfteria, and in other fpafmodic and painful difeafes ; and as a ftimulus in foporofe and apoplectic af- feaions. Regular praaitioners feldom give fo much as half an ounce, much more frequently only a few drops tor a dofe ; but empirics have fometimes ventured upon much larger quantities, and with incredible benefit. When applied externally, it is capa- ble of producing two very oppofite effeas according to its man- agement ; tor, if it be prevented from evaporating, by covering the place to which it is applied clofely with the hand ; it proves a pow- erful ftimulant and rubefacient, and excites a fenfation of burning heat. In this way it is frequently ufed for removing pains in the head or teeth. On the contrary, if it be dropt on any part ot the body, expofed freely to the contaa of the air, its rapid evaporation produces an intenfe degree of cold; and as this is attended with a proportional diminution of bulk in the part applied in this way it has frequently facilitated the reduaion of ftrangulated hernia. The mixture of ether with alcohol, whether prepared direaiy by mixing them as the Edinburgh College direa, or in the im- pure ftate in which it comes over in the firft part of the procefs for diftilling ether, the fpirit of vitriolic ether of the London, arid Chap. XIII.] Of Alcohol, &rV. 489 the vitriolic etherial liquor of the Dublin Colleges, poffeffes firn* ilar virtues with ether, but in an inferior degree. SPIRITUS .ETHERIS NITROSI, Edin. Spirit ef Nitrous Ether. Liquor ^Ethereus Nitrosus. Dub. Nitrous Etherial Liquor, Take of Alcohol, three pounds ; ' Nitrous acid, one pound. Pour the alcohol into a capacious phial, placed in a veffel full of cold water, and, add the acid by degrees, conftantly agitating them. Let the phial be flightly covered, and placed for (even days in a cooj place ; then diftil the liquor with the heat of boil- ing water into a receiver kept cool with water or fnow, till no more fpirit comes over. Spiritus .E,theris Nitrosi. Lond. Spirit of Nitrous Ether, Take of Reaified fpirit of wine, two pints ; Nitrous acid, half a pound. Mix them, by pouring in the acid to the fpirit, and diftil with a gentle heat one pound ten ounces,. This procefs is attended with much greater difficulty and dan- ger than the direaions of the Pharmacopceias would lead us to fuppofe. For the aaion of the acid upon the alchol is fo very violent, that either a large proportion of the etherial produa is diffipated and loft ; or if we attempt to operate in clofe veffels, we run the hazard of breaking ttfem. The aaion of alcohol and nitrous acid upon each other is much influenced by their propor- tions. If we ufe a fmall proportion of alcohol, or pour alcohol into nitrous acid, there immediately, takes place a great increafe of temperature, and a violent effervefcence and difengagement of red fumes. On the contrary, if the acid be added to the alcohol, no apparent aaion takes place until the quantity of acid added amount to about one fourth ot the alcohol ; bubbles of gas then begin to be difengaged, and the aaion is increafed in proportion as more acid is added. By placing the phials containing the alco- hol and acid, in cold, or rather iced water, they may be mixed without danger in the proportions direaed by the Colleges. Dur- ing the period that the mixture is fet at reft in a cool place, the aaion goes on flowly, and at laft ceafes. We may now proceed 490 Preparatidns and Compositions. [Part III. to the diftillation, which muft be performed with a very flow and well regulated fire ; for the vapor is very apt to expand with fo much violence as to burft the veffels ; and the heat muft at no time exceed 212°, otherwife a portion of undecompofed acid will pafs over and fpoil the produa. The fpirit of nitrous ether thus obtained, is a colorlefs fluid, of a fragrant odor, lighter than water, extremely volatile and inflam- mable, poffefling properties in general analogous to the fpirit of fulphuric ether. It fhould not give a blue color to tincture of guaiac, or exhibit any other figns of acidity. By age and expof- ure to the air, it is gradually decompofed, and gives rife to the reproduaion of nitrous acid. When this change has taken place, it may be reaified by faturating the acid with lime water, and re- diftilling the etherial fluid. In all probability it is a mixture of nitrous ether and alcohol ; for by diminifhing the quantity of al- cohol employed, we obtain a fluid having a fimilar relation to the fpirit of nitrous ether, that fulphuric ether has to the fpirit of ful- phuric ether. When alcohol and nitrous acid are mixed in the proportion ne- ceffary for the formation of nitrous ether, the utmoft precautions muft be taken to diminifh their aaion on each other. This may be done by adding the acid to the alcohol, in very fmall portions at a time, and at confiderable intervals. In this way Mr. Dehne procured, from two pounds of alcohol, and one pound eight ounc- es and three drachms of nitrous acid, one pound nine ounces and three drachms of ether ; the refiduum weighed one pound twelve ounces; there was therefore a lofs of three ounces. Dr. Black contrived a very ingenious method of retarding the aaion of ni- trous acid upon alcohol, by rendering their mixture extremely flow. On two ounces of the ftrong acid put into a phial, pour flowly and gradually about an equal quantity of water, which, by being made to trickle down the fides of the phial, will float on the furface of the acid without mixing with it ; then add, in the fame cautious m^.^cr, three ounces of alcohol, which in its turn will float 01 the furface of the water. By this means the three fluids arc kept feparate on account of their different fpecific gravi- ties, and a ftratum of water is interpofed between the acid and fpirit. .The phial containing the fpirit muft be flopped with a conical ftopper, and this ftopper confined to its place by a weak fpring. The phial is now to be fet in a cool place, and the acid will grad- ually afcend, and the fpirit defcend through the water, this laft aaing as a boundary to reftrain their aaion on each other. When this commences, bubbles of gas rife through the fluids, and the acid gets a blue color, which it again lofes in the courfe of a few days, at which time a yellow nitrous ether begins to fwim on the furface. As foon as the formation of air bubbles ceafes, it is time to remove the ether formed ; for if allowed to temain, its quantity Chap. XIV. j Drying of Herbs, &c. 491 decreafes. By this method a quantity of nitrous ether is formed, without the danger of producing elaftic vapors or explofion. The refiduum of this procefs is ftill capable of forming a fpirit of ni- trous ether, with an additional quantity of alcohol,. There is ftill another method ot forming nitrous" ether, which is indeed faid to be preferable to that mentioned. It was firft prac- ticed by M. Voigt. Four pounds of dried nitrate of potafs are to be introduced into a tubulated retort, conneaed with a Woulfe's apparatus ; and a mixture of four pounds of fulphuric acid, and three pounds four ounces of alcohol, is to be poured upon it; Without the application of any external heat, nitrous ether paffes over into the receiver, and the refiduum furnifhes, on more alco- hol being added to it, fpirit of nitrous ether. When alcohol is converted into ether by the aaion of nitrous acid, the change produced on it is nearly the fame with that pro- duced by fulphuric acid. In the latter cafe, it is effeaed by the affinities which form water, and charcoal is precipitated. In the former, it is effeaed by the affinities which form carbonic acid, and no water is formed. Spirit of nitrous ether has been long defervedly held in great efteem. It quenches thirft, promotes the natural fecretions, expels flatulences, and moderately ftrengthens the ftomach. It may be given in dofes of from 20 drops to a drachm, in any conve- nient vehicle. Mixed with a fmall quantity of fpiritus ammonia; aromaticus, it proves a mild, yet efficacious, diaphoretic, and often remarkably diuretic; efpecially in fome febrile cafes, where fuch afalutary evacuation is wanted. A fmall proportion of this fpir- it added to malt fpirits, gives them a flavor approaching to that of Freneh brandy. CHAP. XIV. . HERB ARUM et FLO RUM EXSICCATIO. Lond. the drying oe herbs and flowers. Let thefe, fpread out lightly, be dried by a gentle heat. Edin. Herbs and flowers are to be dried by the gentle heat of a ftove or common fire, in fuch quantities at a time, that the procefs may be finifhed as quickly as poffible; for by this means their - H H 492 Preparations and Compositions. [Part 11/, powers are beft preferved ; the teft of'which is the perfea pref- ervation of their natural color. The leaves of hemlock (conium maculatum) and of other plants containing a fubtile volatile matter, muft be immediately pound- ed, after being dried, and afterwards kept in glafs phials well corked. For further obfervations on the drying and prefervation of fim- ple fubftances, the nth, 16th and 19th paragraphs of the fecond feaion of the firft part of this work may be confulted. SCILLA EXSICCATIO. Lond. The Drying of. Squill. V Cut the fquill, after having removed its dry coats, tranfverfely into thin flices, and dry it by a gentle heat. Scilla Maritima Exsiccata. Edin. Dried Sea Squill. Cut the root of the fea fquill, after having removed its external coat, tranfverfely into thin flices, and dry it by a gentle heat. The fign of its being properly dried is,, that although rendered friable, it retains its bitternefs and acrimony. Scilla Pr/eparata. Dub. Prepared Squills. Cut the fquills, after having removed their membranaceous integu- ments, as thin as poffible, and fufpend the cut flices in the ffiade to dry. When dry, reduce them to powder, which is to be kept in a corked phial. 1 By this method the fquill dries much fooner than when its fev- eral coats are only feparated ; the internal part being here laid bare, which, in each of the entire coats, is covered with a thin fkin, which impedes the exhalation of the moifture. The root lofes in this procefs four fifths of its original weight ; the parts which exhale with a moderate heat appear to be merely watery ; hence fix grains of the dry root are equivalent to half a drachm of it when frefh ; a circumftance to be particularly regarded in the exhibition of this medicine. But it too great heat has been employed to dry it, it becomes almoft inert, and it alfo lofes by long keeping in the ftafe of powder. Dried fquills furnifh us with a medicine, fometimes advantage- oufly employed as an emetic, often as an expeaorant, but ftill more frequently as a powerful diuretic. Chap. XV.] Of Expressed Juices. 493 MILLIPEDE PR/EPARATIO. Lond. The Preparation of Millipeds. Millipede Pr,eparat^e. Dub. Prepared Millipeds. The millipeds are to be inclofed in a thin canvas cloth, and fuf- pended over hot proof fpirit in a clofe veffel, till they be killed by the fteam, and rendered friable. This is the laft remains of a juftly exploded praaice, which afcribed extraordinary virtues to whatever was barbarous and dif- gufting. SPONGIA USTIO. Lond. The burning of Sponge. Spongia Usta. Dub. Burnt Sponge. Cut the fponge in pieces, and bruife it, fo as to free it from frr^U ftones; burn it in a clofe iron veffel, until it becomes black and friable ; afterwards reduce it to a Very fine powder. This medicine has been in ufe for a confiderable time, and employed againft fcrofulous diforders and cutaneous foulneffes, in dofes of a fcruple and upwards. Its virtues probably depend on the prefence of a little alkali. It alfo contains charcoal; and its ufe may be entirely fuperfeded by thefe fubftances, which may be obtained in other manners, at a much cheaper rate^ CHAP. XV. EXPRESSED JUICES. The juices of fucculent plants are obtained by expreffion (§ 50. S. 2.) They are of a very compound nature, confiftingof thefap, the fecreted fluids and fecula mixed together. When firft pro- cured, they are very high colored, turbid, and loaded with paren- chymatous matter. They may be feparated by reft, filtration (§45. S. 2.) heat and clarification, (§53. S. 2.) The firft procefs may be employed when the juice is very fluid, is not fufceptible of al- teration, and does not contain volatile matter. The fecond is per- haps the moft perfea, but it is tedious and applicable only to very fluid juices. In many inftances it may be facilitated by the addition of £8- * / 494 Preparations and Compositions. [Part III. water. The third procefs is more expeditious, and is employed "for juices which are very alterable, or which contain volatile mat- ters. It is performed by fntroducing the juice into a matrafs, and immeifing it in boiling water for fome minutes. The fecuh-e are coagulated, and eafily feparated by filtration. Clarification can only be ufed for very vifcid mucilaginous juices, which contain nothing volatile. It renders them fufficiently fine ; but the heat employed deepens their color, and manifeftly alters them, fo that it is not merely a defecating, but a decompofing procefs. When depurated, juices are yellow or red, but never green. The fluids thus extraaed from fucculent fruits, both of the acid and fweet kind, from moft of the acrid herbs, as fcurvy grafs and water creffes, from the acid herbs, as forrel and wood forrel, from the apperient la61efcent plants, as dandelion and hawkweed, and from fundry other vegetables, contain great part of the peculiar tafte and virtues of the refpeaive fubje£ts. The juices, on the other hand, extraaed from moft of the aromatic herbs, have fcarcely any thing of the flavor of the plants, and feem to differ little from decoaions of them made in water boiled till the vola- tile odorous parts have been diffipated. Many of the odoriferous flowers, as the lily, violet, hyacinth, not only irripart nothing of their fragrance to their juice, but have it totally deftroyed by the previous bruifing. From want of fufficient attention to thefe particulars, praaitioners have beert frequently deceived in the ef- feas of preparations of this clafs; juice of mint has been often prefcribed as a ftomachic, though it wants thofe qualities by which mint itfelf and its other preparations operate. There are equal differences in regard to their preferving thofe virtues, and this independently of the volatility of the aaive mat- ter, or its difpofition to exhale. Even the volatile virtue ot fcur- vy grafs may, by the above method, be preferved almoft entire in its juice for a confiderable time; while the aaive parts of the juice of the wild cucumber quickly feparate and fettle to the bot- tom leaving the fluid part inert. Juices of arum root, iris root, bryony root, and other vegetables, in like manner allow their me- dicinal parts to fettle at the bottom. If juices are intended to be kept for any length of time, about one fortieth part of their weight of good fpirit of wine may be added, and the whole fuffered to ftand as before ; a frefh fediment will now be depofited, from which the liquor is to be poured off, ftrained again, and put into fmall bottles which have been wafhed with fpirit and dried. A little oil is to be poured on the fur- face, fo as very nearly to fill the bottles, and the mouths clofed with leather, paper, or flopped with ftraw, as the flafks are in which Florence oil is brought to us ; this ferves to keep out duft, and fuffers the air to efcape, which in procefs of time arifes from all vegetable liquors, and which would otherwife endanger the burft- Chap. XV.] Of Expressed Juices. 495 ing of the glaffes; or, being imbibed afrefli, render their contents vapid and foul. The bottles are to be kept on the bottom of a good cellar ©r vault, placed up to the necks in fand. By this me- thod fome juices may be preferved for a year or two ; and others for a much longer time, though, whatever care be taken, they are found to anfwer better when frefli ; and from the difficulty of pre- ferving them, they have of late been very much laid afide, efpe- cially fince we have been provided with more convenient and ufe- ful remedies. The following is the only compofition" of the kind retained in our Pharmacopceias. SUCCUS COCHLEARIA COMPOSITUS. Lond. Compound Juice of Scurvy Grafs. Take of Juice of Garden fcurvy grafs, two pints ; Brooklime, Water creffes, of each one pint; Seville oranges, twenty ounces by meafure. Mix them, and, after the feces have fubfided, pour off the liquor, or ftrain it. Succus Cochlearia Officinalis Compositus; vulgo, Succiad Scorbuticos. Edin. Compound Juice of Scurvy Grafs. Take of Juice of Scurvy grafs, Water creffes, expreffed from frefh gathered herbs, Seville oranges, ot each two pounds; Spirit of nutmegs, halfa pound. Mix them, and let them ftand till the feces have fubfided, then pour off the clear liquor. Both thefe compofitions are of confiderable ufe for the pur- pofes expreffed in the title ; the orange juice is an excellent affift- ant to the fcurvy grafs and other acrid antifcorbutics ; which, when thus mixed, have been found from experience to produce much better effeas than when employed by themfelves. They may be taken in dofes from an ounce or two to a quarter of a pmt two or three times a day ; they generally increafe the urinary fe» cretion, and fometimes induce a laxative habit. 63*3 496 Preparations and Compositions. [Part III. CHAP. XVI. INSPISSATED JUICES. This is a very convenient form for the exhibition of thofe fub- ftances which are fufficiently fucculent to afford a juice by ex- breffion, and whofe virtues do not refide in any very volatile mat- ter. By infpiffation, the bulk ot the requifite dofe is very much diminiffied; they are reduced to a form convenient for making up into pills ; and they a*e much lefs apt to fpoil than the fimple expreffed juices. SUCCUS SPISSATUS ACONITI NAPELLI, • Edin. Infpiffated Juice of Wolfsban e. Bruife the frefh leaves of wolfsbane ; and including them in a hempen bag, cotnprefs them ftrongly till they yield their juice, which is to be evaporated in flat veffels heated with boiling wa- ter, faturated with muriate of foda, and immediately reduced to the confiftence of thick honey. After the mafs has become cold, let it be put up in glazed earthen veffels, and moiftened with alcohol. In the fame manner are prepared from their leaves, SUCCI SPISSATI The Infpiffated Juices of Atropa Belladonna, Deadly Nightfhade. Conii Maculati, Hemlock. Hyosciami nigri, Henbane. Lactuca virosa, Poifonous Lettuce. SUCCUS BACOE SAMBUCI SPISSATUS. Lond. Infpiffated Juice of the Elder, berry. Take of Expreffed and depurated juices of Elder berries, two pints. Infpiffate in a water bath faturated with fea fait. In the fame manner infpiffate SUCCUS The Juice of the Ribis nigri, BlackCurrant. Limonis, Lemon- Cicuta; floribus pri- Hemlock when about mum apparentibus. to flower. Chap. XVI.] Of Inspissated Juices. 497 SUCCUS SPISSATUS C1CUT/E. Dub. Infpiffated Juice of Hemlock. Exprefs hemlock gathered when the flowers are juft appearing, and allow the juice to ftand fix hours until the feces fubfide ; then reduce the decanted juice to drynefs in a water bath. In the fame way is prepared Succus Spissatus Sambuci, The Infpiffated Juice of El- der berries, from frefh gathered berries. SUCCUS SPISSATUS SAMBUCI NIGRI ; vulgo, Rob Sambuci. Edin. Infpiffated Juice of Elder berries, commonly called Elder Rob. Take of Juice of ripe Elder berries, five pounds ; Pureft fugar, one pound. Evaporate with a gentle heat to the confiftence of pretty thick honey. These infpiffated juices contain the virtues of therefpeaive vegetables in a very concentrated ftate. Thofe of the elder, black current, and lemon, are acidulous, cooling and laxative, and may be ufed in confiderable quantities, while thofe of the wolfs- bane, hemlock, deadly nightfhade, henbane and poifonous let- tuce, are highly narcotic and deleterious, and muft be given only in very fmall dofes. SUCCUS SPISSATUS MOMORDIOE ELATF.RII ; vul- go, Elaterium. Edin. Infpiffated Juice of the Wild Cucumber. Elaterium. Lond. Elaterium. Cut into flices ripe wild cucumbers, and pafs the juice, very light- ly expreffed, through a very fine hair fieve, (into a glafs veffel Lond.) then boil it a little and fet it by for fome hours until the thicker part has fubfided. Pour off the thinner part fwim- ming at the top, and feparate the reft by filtering. Cover the thicker part which remains after the filtration, with a linen cloth and dry it with a gentle heat. This is not properly an infpiffated juice, butadepofition from the expreffed juice. Such depofitions have long been called Fe- rula, and the denomination has been confirmed in modern times. 498 Preparations and Compositions. [Part III. Its application, however, appears to us to be too extended ; for feculum is applied both to mild and nutritious fubftances, fuch as ftarcn, and to draftic fubftances, fuch as that of which we are now treating. Befides, it it poffeffed exaaiy the fame chemical pro- perties as ftarch, it would be converted into a gelatinous mafs by the boiling direaed by the Edinburgh College, and would not fe- perate ; whereas, the boiling is intended to promote the fepara. tion. The filtration above direaed,' for draining off fuch part of the watery fluid as cannot be feparated by decantation, is not the common filtration through paper, for this does not fucceed here. The groffer parts of the juice, falling to the bottom, form a vifcid cake upon the paper, which the liquid cannot pafs through. The feparation is to be attempted in another manner, by draining the fluid from the top. This is effetfed by placing one end ot fome moiftened ftrips of woollen cloth, fkeins of cotton, or the like, in the juice, and laying the other end over the edge of the veffel fo as to hang down lower than the furface of the liquor ; by this management the feparation fucceeds in perfeaion. Elaterium is a very violent hydragogue cathartic, In general, previous to its operation, it excites confiderable ficknefs, at ftom- ach, and not unfrequently it produces fevere vomiting. Hence it is feldom employed till other remedies have been tried in vain. But in fome inftances of afcites it will produce a complete evacu- ation of water, where other cathartics have had no effea. Two or three grains are in general a fufficient dofe. And perhaps the beft mode of exhibiting it, is by giving it only to the extent of half a^rain at a time, and repeating that dofe every hour till it begins to operate. PULPARUM EXTRACTIO. Edin. Dub. The Extraclion of Pulps. Boil unripe pulpy fruits, and ripe ones if they be dry, in a fmall quantity of water until they become foft; then prefs out the pulp through a hair fieve, and afterwards boil it down to the confiftence of honey in an earthen veffel, over a gentle fire ; taking care to keep ftirring the matter continually. (The pulp of caffia fiftularis is in like manner to be boiled out from the bruifed pod, and reduced afterwards to a proper con- fiftence, by evaporating the water.' The pulps of fruits that are both ripe and frefh, are to be preffed out through the fieve, without any previous boiling. Edin.) Chap. XVII.] Of Fixed Gil:. ---' PULPARUM PRAPARATIO. Lond. The Preparation of Pulps. Set pulpy fruits if they be unripe, or ripe and dry, in a moift place,that they may become foft, then prefs the pulps through a hair fieve ; afterwards boil them firft with a gentle heat, and ftir them frequently, then evaporate the water in a water bath, faturated with fea fait, until the pulps acquire the proper con- fiftency. Pour boiling water on the bruifed pods of the caffia fiftularis, fo as to wafh out the pulp ; then prefs the matter firft through a coarfe fieve and then through a hair fieve ; laftly, evaporate the moifture in a water bath, faturated with fea fait, fo as to re- duce the pulp to a proper confiftency. Exprefs the pulps of ripe recent fruits through a fieve, without boiling them. When thefe fruits are not fufficiently juicy to afford a pulp by fimple expreffion, the decoaion ordered by the Edinburgh and Dublin Colleges is much more certain, and in every refped pre- ferable to expofing them to a moift air, which is not only often inefficacious but is apt to render them fpoiltand mouldy. On the other hand the precaution ufed by the London college, of finifh- ing the evaporation in a water bath, is highly proper, as other- wife they are extremely apt to become empyreumatic. CHAP. XVII. FIXED OILS. These oils are commonly denominated Expreffed Oils, an appellation which is manifeftly improper, as in fome inftances they are obtained without expreffion, and in other inftances ex- preffion is employed to obtain Volatile Oils. The Edinburgh College have therefore diftinguifhed thefe different clafles of oils by the terms Fixed and Volatile, which accurately charaaeri.-e them. Fixed oil is formed in no other part of vegetables than in their feeds. Sometimes, although very rarely, it is contained in the parenchyma of the fruit. Of this the beft known example is tht olive. But it is moft commonly found in the feeds ot dicotyle- donous vegetables, fometimes alfo in the fruit of monocbtyledo- nous plants, as the cocos butyracea. It has various degrees of confiftency, from the tallow of the croton febiferum of China, and 500 Preparations and Compositions. [Part III. the butter of the butter tree of Africa, to the fluidity of olive oil. Fixed oil is feparated from fruits and feeds which contain it, either by expreffion or decoaion. Heat, by rendering the oil more limpid, increafes very much the quantity obtained by ex- preffion ; but as it renders it lefs bland, and more apt to become rancid, heat is not ufed in the preparation of oils which are to be employed in medicine. When obtained by expreffion, oils often contain a mixture of mucilage, ftarch and coloring matter ; but part ot thefe feparate in courfe of time, and fall to the bottom. When oils become rancid, they are no longer fit for internal ufe, but are then faid to effea the killing of quickfilver, as it is call- ed more quickly. Decoaion is principally ufed for the extrac- tion of the pifcid and confiftent oils, which are melted out by the heat of the boiling water, and rife to its furface. OLEUM AMYGDALAE COMMUNIS. Edin. Almond Oil, Take of Frefh almonds, any quantity. After having bruifed them in a ftone mortar, put them into a hempen bag, and exprefs the oil without heat. I n the fame manner is to be expreffed from its feeds, Oleum Lini Usitatissimi, Oil of Linfeed, Oleum Amygdala. Lond. Almond Oil. Pound freffi almonds, either fweet or bitter, in a mortar, then prefs out the oil in a cold prefs. In the fame manner are to be expreffed. Oleum Lini, Linfeed Oil, from the bruifed feeds. Oleum Ricini, Caftor Oil, from the feeds previoufly de- corticated. Oleum Sinapeos, Oil of Muftard, from the bruifed feeds. Oleum Amygdalarum. Dub. Oil of Almonds. Bruife frefli almonds in a mortar, and exprefs the oil in a prefs without heat. In the fame way are to be expreffed from the feeds, Oleum Lini, Linfeed Oil. Oleum Sinapis, Oil of Muftard. Chap. XVIII.] Of Oily Preparations. 501 The chemical properties of thefe oils have been already (§234) mcntioned, and an account of the medical virtues ot each will be found in their refpeaive places in the Materia Med- ica. CHAP. XVIII. OILT PREPARATIONS, OLEUM AMMONIATUM, vulgo Linimentum Vola? x tile. Edin. Ammoniated Oil, commonly called Volatile Liniment. Take of Olive oil, two ounces ; Water of ammonia, two drachms. Mix them together. # Linimentum Ammonia Fortius. Lond. Stronger Liniment of Ammonia. Take of Water of pure ammonia, one ounce ; Olive oil, two ounces. Shake them together in a phial. Linimentum Ammonite. Lond. Liniment of Ammonia. Take of Water of ammonia, half an ounce ; Olive oil, one ounce and a half. Shake them together in a phial till they are mixed. The moft commonly adopted generic name for the combina- tion of oil with alkalies is Soap, and the fpecies are diftinguifhed by the addition of that of the alkali they contain. On thefe prin- ciples, volatile liniment fhould be called Soap of Ammonia, as hard foap is foap of foda, and foft foap, foap of potafs. The ammonia ufed in the two firft of thefe preparations com- bines much more eafily and intimately with the oil than the car- bonate of ammonia uled in the laft. If the carbonate be employ- £02 Preparations and Compositions. [Part III. ed with the view of rendering the preparation lefs ftimulating, the fame end will be more fcientifically obtained, bv increafing the proportion of oil mixed with pure ammonia. The two firft of thefe liniments differ greatly in point of ftrength, the propor- tion of water of ammonia in the firft, being as 1 to 8, and in the fecond as i to 2. They are very frequently ufed externally as ftimulants and rube- facients. In inflammatory fore throats, a piece of flannel moiften- ed with thefe foaps, applied to the throat, and renewed every four or five hours, is one of the moft efficacious remedies. By means of this warm ftimulating application, the neck, and fometimes the whole bodv, is put into a fweat, which after bleed- ing either c<:: ies off, or lcffens the inflammation. When too ftronrr, or too liberally applied, they fometimes occafion inflam- mations, and even :?ii tiers. Where the fkin cannot bear their acri- mony, a lager proportion of oil may be ufed. But the firft of thefe preparations is even fometimes ufed inter- nally, made into a mixture with fyrup and fome aromatic water. A drachm or two taken in this manner three or four times a day, is a powerful remedy in fome kinds of catarrh and fore throat. ' OLEUM LINI CUM CALCE. Edin. Linfeed Oil with Lime. Take of Linfeed oil, Lime water, of each equal parts. Mix them. This liniment is extremely ufeful in cafes of fcalds or burns, being fingularly efficacious in preventing, if applied in time, the inflammation fubfequent to burns or fcalds ; or even in removing it, after it has come on. It is alfo a fpecies of foap, and might be called Soap of Lime, although it probably contains a great excefs of oil. OLEUM CAMPHORATUM. Edin. Camphorated Oil. Take of Olive oil, two ounces ; Camphor, half an ounce. Mix them fo that the camphor may be diffolved. This is a fimple folution of camphor in fixed oil, and is an ex- cellent application to local pains from whatever caufe, and to glandular fwellings. fchap. XIX.] Of Distilled Waters. 503 OLEUM SULPHURATUM. Edin. Sulphurated oil. Take of Olive oil, eight ounces; Sublimed Sulphur, one ounce, Boil, them together in a large iron pot, ftirring them continually, till they unite. Lond. Take of Flowers of fulphur, Olive oil, fixteen ounces, by weight, Boil the flowers of fulphur, with the oiJ, in a pot flightly cover- ed, until they be united. In the fame way is made, Petroleum Sulphuratum. Lond. Sulphurated Petroleum. Sulphurated oil was formerly ftrongly recommended in coughs, confumptions, and other diforders of thebreaft and lungs. But the reputation which it had in thefe cafes, does not appear to have been derived from any fair trial or experience. It is mani- feftly hot, acrimonious, and irritating ; and fhould therefore be uf- ed with the utmoft caution. It has frequently been found to irf- jure the appetite, offend the ftomach and vifcera, parch the body, and occafion thirft and febrile heats. The dofe of it is from ten to forty drops. It is employed externally for cleanfing and heal- ing foul running ulcers; and Boerhaave conjeaures that its ufe in thefe cafes gave occafion to the virtues afcribed to it when ta- ken internally. CHAP. XIX. DISTILLED WATERS. Substances which differ in volatility, may be feparated from each other by applying a degree of beat capable of converting the moft volatile into vapor, and by again condenfing this vapor in a proper apparatus. Water is converted into vapor at 212°, and may be feparated by diftillation from the earthy and faline mat- ters which it always contains in a natural ftate. But, it is evi- dent that if any fubftances which are as volatile as water, be ex- 504 Preparations and Compositions. [Part III. pofed to the fame degree of heat, either by immerfing them in boiling water, or expofing them to the aaion of its fleam, they will rife with it in diftillation. In this way the camphor and vo- latile oils of vegetable fubftances are feparaied from the more fix- ed principles ; and as water is capable of diffolving a certain quan- tity of thefe volatile fubftances, it may be impregnated with a great variety of flavors by diftilling it from different aromatic fubftances. If the fubjea of our diftillation contain more volatile oil than the water employed is capable of diffolving, it will ren- der the water milky, and afterwards feparate from it. It is in this way that effential oils are obtained. Effential oils are obtained only from odoriferous fubftances ; but not equally from all of this clafs, nor in quantity proportional to their degree of odor. Some, which, if we were to reafon trom analogy, fhould feem very well fitted for this procefs, yield ex- tremely little oil, and others none at all. Roles and chamomile flowers, whofe ftrong and lafting fmell promifes abundance, are found to contain but a fmall quantity of oil ; the violet and jeffa- mine flower, which perfume the air with their odor, lofe their fmell upon the gentleft coaion, and do not afford any oil, on being diftilled, unlefs immenfe quantities are fubmitted to the operation at once ; while favin, whofe difagreeable fcent extends to a great diftance, gives out the largeft proportion of oil of almoft any veg- etable known. Nor are the fame plants equally fit for this operation, when pro- duced indifferent foils or feafons, or at different times of their growth. Some yield more oil, if gathered when the flowers be- gin to fall off than at any other time. Of this, we have exam- ples in lavender and rue ; others, as fage, afford the largeft quan- tity when young, befoie they have fent forth any flowers ; and others, as thyme, when the flowers have juft appeared. All fra- grant herbs yield a larger proportion of oil, when produced in dry foils and in warm fummers, than in oppofite circumftances. On the other hand, fome of the difagreeable ftrong fcented ones, as wormwood, are faid to contain moft oil in rainy feafons, and when growing in moift rich grounds. Several chemifts have been of opinion, that herbs and flowers, moderately dried, yield a greater quantity of effential oil, than if they were diftilled when frefh. It is, however, highly improb- able, that the quantity of effential oil will be increafed by drying, on the contrary part of it muft be diffipated and loft. But drying may fometimes be ufeful in other ways ; either by diminifhing the bulk of the fubjea to be diftilled, or by caufing it to part with its oil more eafily. The choice of proper inftruments is of great confequence for the performance of this procefs to advantage. There are fome oils which pafs freely over the fwan neck of the head of the com. Chap. XIX.] Of Distilled Waters. 505 mon ftill ; others lefs volatile, cannot eafily be made to rife fo high. For obtaining thefe laft, we would recommend a large low head, having a rim or hollow canal round it ; in this canal, the oil is detained on its firft afcent, and thence conveyed at once into the receiver, the advantages of which are fufficiently obvious. With regard to the proportion of water to be employed ; it whole plants, moderately dried, are ufed, or the ffiavings of woods as much of either may be put into the veffel as, lightly preffed, will occupy half its cavity ; and as much water may be added, as will fill two thirds of it. When frefh and juicy herbs are to be diftilled, thrice their weight of water will be fully fufficient; but dry ones require a much larger quantity. In general, there fhould be fo much water, and after all intended to be diftilled has come over, there may be liquor enough left to prevent the matter from burning to the ftill. The water and ingredients, altogether, fhould never take up more than three fourths of the ftill ; there fhould be liquor enough to prevent any danger of an empyreuma, but not fo much as to be apt to boil over into the receiver. The fubjea ot diftillation fhould be macerated in the water un- til it be perfeaiy penetrated by it. To promote this effea, woods fhould be thinly ffiaved acrofs the grain, or fawn, roots cut tranf- verfely into thin flices, barks reduced into coarfe powder, and feeds flightly bruifed. Very compaa and tenacious fubftances re- quire the maceration to be continued a week or two, or longer ; for thofe ofa fofter and loofer texture, two or three days are fuffi- cient ; while fome tender herbs and flowers not only ftand in no need of maceration, but are even injured by it. The fermenta- tion which was formerly prefcribed in fome inftances, is always hurtful. With regard to the fire, the operator ought to be expeditious in raifing it at firft, and to keep it up during the whole procefs to fuch a degree only, that the oil may freely diftil ; otherwife the oil will be expofed to an unneceffary heat \ a circumftance which ought as much as poffible to be avoided. Fire communicates to all thefe oils a difagreeable impregnation, as is evident from their being much lefs grateful when newly diftilled, than after they have flood for fome time in a cool place ; and the longer the heat is continued, the greater alteration it produces in them. The greater number of oils require for their diftillation the heat of water ftrongly boiling; but there are many alfo which riffc with a heat confiderably lefs; fuch as thofe of lemon and citron peel, of the flowers of lavender and rofemary, and of almoft all the more odoriferous kinds of flowers. We have already obferv- ed, that thefe flowers have their fragrance much injured, or even deftroyed, by beating or bruifing them ; it is impaired alfo by tfhe 506 Preparations and Compositions. [Part III. immerfion in water in the prefent procefs, and the more fo in pro- portion to the continuance of the immerfion and the heat ; hence oils, diftilled in the common manner, prove much lefs agreeable in fmell than the fubjeefs themfelves. For the diftillation of fub- ftances of this clafs, another method has been contrived ; inftead of being immerfed in water, they are expofed only to its vapor. A proper quantity of water being put into the bottom of the ftill, the odoriferous herbs or flowers are laid lightly in a bafket of fuch a fize that it may enter into the ftill, and reft againft its fides, juft above the water. The head being then fitted on, and the water made to boil, the fleam percolating through the fubjea, imbibes the oil, without impairing its fragrance, and carries it over into the receiver. Oils thus obtained, poffefs the odor of the fubjea in an exquifite degree, and have nothing of the difagreeable fcent perceivable in thofe diftilled by boiling them in water in the com- mon manner. Plants differ fo much according to the foil and feafon of which they are the produce, and' likewife according to their own ages, that it is impoffible to fix the quantity of water to be drawn from a certain weight of them to any invariable ftandard. The diftil- lation may always be continued as long as the liquor runs well flavored off the fubjea, and no longer. In the diftillation of effential oils, the water, as was obferved in a foregoing feaion, imbibes always a part of the oil. The dif- tilled liquors here treated of, are no other than water thus impreg- nated with the effential oil of the fubjea ; whatever fmell, tafte, or virtue, is communicated to the water, or obtained in the form ofa watery liquor, being found in a concentrated ftate in the oil. All thofe vegetables therefore which contain an effential oil, will give over fome virtue to water by diftillation ; but the de- gree of the impregnation of the water, or the quantity of water which a plant is capable of faturating with its virtue, are by no means in proportion to the quantity of its oil. The oil faturates only the water that comes over at the fame time with it; if there be more oil than is fufficient for this faturation, the furplus fepar- ates and concretes in its proper form, not mifcible with the wa- ter that arifes afterwards. Some odoriferous flowers, whofe oil is info fmall quantity that fcarcely any vifible mark of it appears, unlefs fifty or an hundred pounds or more are diftilled at once, give neverthelefs as ftrong an impregnation to water as thofe plants which abound moft with oil. Many have been of opinion, that diftilled waters may be more and more impregnated with the virtues of the fubjea, and their ftrength increafed to any affigned degree, by cohobation, that is, by rediftilling them repeatedly from frefh parcels of the plant.— Experience, however, fhows the contrary. A* water fkill- fully drawn in the firft diftillation, proves on every repeated one not ftronger but more difagreeable. Aqueous liquors are not ca* Chap. XIX.] Of Distilled Waters. 507 pable of imbibing above a certain quantity ot the volatile oil of vegetables; and this they may be made to take up by one, as well as by any number of diftillations ; the oftener the procefs is re- peated, the ungrateful impreffion which they generally receive from the fire, even at the firft time, becomes greater and greater. Thofe plants, which do not yield at firft waters fufficiently ftrong, are not proper fubjeas for this procefs. The mixture of water and oil which comes over, is to be put into large narrow necked bottles, and placed in a cool place, that the portion of oil which is not diffolved in the water may rife to the top, or fink to the bottom, according to its fpecific gravity. It is then to be feparated, either by a feparatory (Plate I. fig. 10.) or by means of a fmall glafs fyringe ; or by means of a filter of paper ; or, laftly, by means of a woollen thread, one end of which is immerfed in the oil, and the other lower end in a phial ; the oil will thus pafs over into the phial by capillary attraaion, and the thread is to be fqueezed dry. Moft diftilled waters, when firft prepared, have a fomewhat un- pleafant fmell, which however they gradually lofe ; it is therefore advifable to keap them for fome days after their preparation in veffels but flightly covered; and not to cork them up until they lofe that fmeli. That the waters may keep the better, about one twentieth part their weight of proof fpirit may be added to each after they are diftilled. Diftilled waters are employed chiefly as grateful diluents, as fuitable vehicles for medicines of greater efficacy, or for render- ing difguftful ones more acceptable to the palate and ftomach ; few are depended on, with any intention of confequence, by them- felves. To the chapter on Simple Diftilled Waters, the London Col- lege have annexed the following remarks. We have ordered moft of the waters to be diftilled from the dried herbs, becaufe frefh are not ready at all times of the year. Whenever the frefh are ufed, the weights are to be increafed. But, whether the frefh or dried herbs be employed, the operator may vary the weight according to the feafon in which they have been produced and colleaed. Herbs and leeds kept beyond the fpace of a year, become lefs proper tor the diftillation of waters. To every gallon of thefe waters add five ounces, by meafure, of proof fpirit. The Edinburgh College order half an ounce of proof fpirit to every pound of water, which is nearly the fame. But the Dublin College order five ounces of proof fpirit to be added to each pound. The word pound is probably printed by miftake for gallon. I i 508 Preparations and Compositions. [Part III. AQUA DISTILLATA. Lond. Diftilled Water. Take of Spring water, ten gallons. Draw off by diftillation, firft, four pints ; which being thrown away, draw off four gallons. This water is to be kept in a glafs or earthen bottle with a glafs ftopper. Dub. Take of Spring water, twenty pounds. Put it into a retort, and having thrown away the firft pound, draw off ten pounds by diftillation with a gentle heat. Edin. Let water be diftilled in very clean veffels, until about two thirds have Come over. WateR is never found pure in a ftate of nature ; and as it is abfolutely neceffary, particularly for many chemical operations, that it fhould be perfeaiy fo, we muft feparate it from all hetero- geneous matters by diftillation. The firft portion that comes over fhould be thrown away, not fo much from the poffibility of its being impregnated with volatile matters contained in the water, as from the probability that it will be contaminated with impu- rities it may have contraaed in its paffage through the worm in the refrigeratory. The diftillation is not. to be pufhed too far, left the water fhould acquire an empyreumatic flavor. Although diftilled water be neceffary for many purpofes, we apprehend that the London College, from a defire of extreme el- egance^ have fallen into a very confiderable error in ordering it to be employed for many purpofes, fuch as infufions and decoctions, for which good fpring water would anfwer juft as well, and for which, we will venture to fay, that it never is employed by the a- pothecary. The confequence is, that the apothecary has no rule to direa him, when it is abfolutely neceffary, and when it may be difpenfed with, and he will therefore probably difpenfe with it oftner than is proper. AQUA CITRI AURANTII. Edin. Orange Peel Water. Take of Frefh orange peel, two pounds. Pour upon it as much water as fhall be fufficient to prevent any empyreuma, after ten pounds have been drawn off by diftilla- tion. After due maceration, diftil ten pounds. Chap. XIX.] Of Distilled Waters. 509 Aqua Foeniculi Dulcis. Dub. Lond. Fennel Water. Take of The bruifed feeds of fweet fennel, one pound ; Water, as much as may be fufficient to prevent empyreuma; Diftil one gallon (ten pounds) Dub. The fame quantity of water is to be diftilled in the fame man- ner from Six pounds of the recent petals of the Damask Rose, Aqua Rofa Centifolia. Edin. Aqua Rofiz. Lond. Dub. * Three pounds, Edin. ; one pound and a half, Lond. Dub, of Peppermint, Aqua Mentha Piperita. Edin. Aqua Mentha Piperitidis. Lond. Dub. Three pounds, Edin. ; one pound and a half, Lond. Dub. of Pennyroyal, in flower, Aqua Mentha Pulegii. Edin. Aqua Pulegii. Lond. Dub. Two pounds of frefh Lemon Peel, Aqua Citri Medica. Edin. One pound and a half of Spearmint, Aqua Mentha Sativa. Dub. Lond. One pound of Cinnamon, (macerated for a day, Lond. Dub.) Aqua Lauri Cinnamoni. Edin. Aqua Cinnamoni. Lond. Dub. One pound of Cassia, Aqua Lauri Caffia. Edin. One pound of bruifed Dill Seeds, Aqua Anethi. Lond. Half a pound of Pimento (macerated for a day, Lond.) Aqua Myrti Pimenta. Edin. Aqua Pimento. Lond. The virtues of all thefe waters are nearly alike ; and the pecu- liarities of each will be eafily underftood by confulting the ac- count given in the Materia Medica of the fubftance from which they are prepared. We will only mention, that as rofe water is exceedingly apt to fpoil, the apothecaries generally prepare it in fmall quantities at a time from the leaves, preferved by packing them clofely in cans with common fait. IQ-2 510 Preparations and Compositions. f/Part. Ill- CHAP. XX. VOLATILE OILS. OLEA VOLAT1LIA. Edin. Volatile Oils. Volatile Oils are prepared nearly in the fame manner as the diftilled waters, except that lefs water is to be added. Seeds and woody fubftances are to be previoufly bruifed or rafped. The oil comes over with the water, and is afterwards to be fep- arated from it, according as it may be lighter than the water, and fwim upon its furface, or heavier, and fink to the bottom. Befides, in preparing thefe diftilled waters and oils, it is to be ob- ferved, that the goodnefs of the fubjea, its texture, the feafon of the year, and fimilar caufes, muft give rife to fo many differ- ences that no certain or general rule can be given to fuit accu- rately each example. Therefore many things are omitted, to be varied by the operator according to his judgment, and only the moft general precepts are given. OLEA DISTILLATA. Lond. Diftilled Oils. Let thefe oils be drawn off by diftillation, from an alembic with a large refrigeratory ; but, to prevent empyreuma, water muft be added to the ingredients; in which they muft be macerated before diftillation. The water which comes over with the oil in diftillation is to be kept for ufe. Dub. Let the oil be extraaed by diftillation from the fubjea previoufly macerated in water, with the addition of as much water as may be fufficient to prevent empyreuma. In diftilling fennel, peppermint, fpearmint, and pennyroyal, the water which comes over along with the oil, is to be preferved for ufe in the manner direaed in the chapter on Diftilled Wa- ters. The herbs from which oils are to be extraaed by diftillation, are to be dried as foon as they are colleaed. Chap. XX.] Of Volatile Oils. 511 According to thefe direaions are prepared the Volatile diftilled, or Effential Oils of Anife, Caraway, Fennel feeds, Juniper berries, Pimento, Fennel flowers, Rofemary, Lavender, Peppermint, Spearmint, Pennyroyal, Origanum, Rue, Olea Volatilia, Edin. Difiillata. Dub. vel. Efifentialia. Lond. Pimpinella anifi. Edin. Anifi. Lond. Dub. Carui. Lond. Dub. Seminumfaniculi dulcis. Dub. from the Seeds. { Juniperi communis. Edin. Baccarum Juniperi. Dub. Juniperi bacca. Lond. from the Berries. Myrti pimenta. from the Fruit. Edin. Dub. Edin. Florumfaniculi dulcis. C Rorifmarini officinalis. 5 Rorifmarini. Lond. Dub. C Lavendulafpica. Edin. y Lavendulx. Lond. C Mentha piperita. Edin. 5 ------piperitidis. Lond. Dub. -------fativa. Lond. Dub. Pulegii. Lond. Dub. Origani. Lond. Dub. Ruta. Dub. Juniperifabina. Sabince. Dub. Savine, From the Flower, or Herb in flower. Saffafras, \ Lauri faffafras V Saffafras. Lond. from the Root. Edin. And of Edin. OLEUM TEREBINTHINA. Lond. Du'±. Oil of Turpentine. Take of Common turpentine, five pounds. Water, four pints, (four pounds, Dub.) iQ°3 512 Preparations and Compositions. [Part III. Diftil (two pounds, Dub.) (the turpentine with the water in a cop- per alembic, Lond.) After the diftillation of the oil, what re- mains (in ihe retort, Dub.) is yellow refin. OLEUM TEREB1NTH1NA VOLATILE PURISS1MUM. Edin. Oleum Terebinthina Rectificatum. Lond. Dub. Re&ified oil of Turpentine. Take of Oil of turpentine, one pound (two pounds, Dub.) Water, four pints (four pounds, Dub. Diftil (a pound and a half, Dub.) as long as any oil comes over, Edin. The procefs here propofed for reaifying this oil, is not only tedious, but accompanied with danger. For unlefs the luting be very clofe, fome of the vapour will be apt to get through ; and if this catch fire, it will infallibly burft the veffels. This reaified oil, which in many pharmacopceias is ftyled Ethereal, does not confiderably differ in fpecific gravity, fmell, tafte, or medical quali- ties, from the former. The Spirit of Turpentine, as this effential oil has been ftyled, is frequently taken internally as a diuretic and fudorific ; and it has fometimes a confiderable effea when taken to the extent of a few drops only. It has, however, been given in much larger dofes, efpecially when mixed with honey. Recourfe has principally been had to fuch dofes in cafes of chronic rheumatifm, particular- ly in thofe modifications of it which are termed fciatica and lum- bago, but fometimes they induce bloody urine. The water employed in the diftillation of volatile oils always imbibes fome portion of the oi}; as is evident from the fmell, tafte, and color, which it acquires. It cannot, however, retain above a certain quantity ; and theretore, fuch as has been already ufed and almoft faturated itfelf, may be advantageoufly employed, inftead of common water, in a fecond, third, or any future diftillation of the fame fubjea. After the diftillation of one oil, particular care fhould be had du- ly to cleanfe the worm belore it be employed in the diftillation of a different fubftance. Some oils, thofe of wormwood and anifeeds for inftance, adhere to it fc^tenacioufly, as not to be melted out by heat, or wafhed off by water ; the beft way ot cleanfing the worm from thefe, is to run a little fpirit of wine through it. Volatile oils, after they are diftilled, fhould be fuffered to ftand for fome days, in veffels loofely covered with paper, till they have loft their difagreeable fiery odor, and become limpid j then Chap. XX.] Of Volatile Oils. 513 put them up in fmall bottles, which are to be kept quite full, clofely flopped, in a cool place. With thefe caution s, they will retain their virtues in perteaion for many years. Moft of the oils mentioned above, are prepared by our chemifts in Britain, and are eafily procurable in a tolerable degree of per- feaion : But the oils from the more expenfive fpiceries, though ftill introduced among the preparations in the foreign Pharrna- copoeas, are, when employed among us, ufually imported from abroad. Thefe are, frequently fo much adulterated, that it is not an eafy matter to meet with fuch as are at all fit for ufe. Nor are thefe adulterations eafily difcoverable. Thegroffer abufes, indeed, may be readily deteaed. Thus, if the oil be mixed with fpirit of wine, it will turn milky on the-addition of water; if with expreffed oils, reaified fpirit will diffolve the volatile and leave the other behind; if with oil of turpentine, on dipping a piece of paper in the mixture, and drying it with a gentle heat, the turpentine will be betrayed by its fmell. But the more fubtle artffls have con- trived other methods of fophiftication, which elude all trials of this kind. Some have looked upon the fpecific gravity of o>ls as a certain criterion of their genuinenefs. This, however, is not to be ab- folutely depended on ; for the genuine oils, obtained from the fame fubje6ts, often differ in gravity as much as thofe drawn from different ones. Cinnamon and cloves, whofe oils ufually fink in water, yield, if flowly and warily diftilled, oils of great fragran- cy, which are neverthelefs fpecifically lighter than the aqueous fluid employed in their diftillation ; whilit, on the other hand, the iaft runnings of fome of the lighter oils prove fometimes fo ponderous as to fink in water. As all volatile oils agree in the general properties ot folubility in fpirit of wine, indiffolubility in water, mifcibility with water by the intervention of certain intermedia, volatility in the heat of boiling water, &c. it is plain that they may be varioufly mixed with each other, or the dearer fophifticated with the cheaper, without any poffibility of difcovering the abufe by any trials of this kind. And, indeed, it would not be of much, advantage to the purchafer, if he had infallible criteria of the genuinenefs of every individual oil. It is of as much importance that they be good, as that they be genuine ; for genuine oils, from inattentive diftil- lation, and long and carelefs keeping, are often weaker both in fmell and tafte than the common fophifticated ones. The fmell and tafte feem to be the only certain tefts of which the nature of the thing will admit. If a bark fhould have in every refpea the appearance of good cinnamon, and fhould be proved indifputably to be the genuine bark of the cinnamon tree; yet if it want the cinnamon flavor, or has it but in a low degree, (FT 4 514 Preparations and Compositions. [Part ITT. we rejea it ; and the cafe is the fame with the oil. It is only from ufe and habit, or companions with fpecimcns of known qual- ity that we can judge of the goodnefs, either of the drugs them- felves or of their oils. Moft of the volatile oils indeed, are too hot and pungent to b~ tafted with fafety ; and the fmell of the fubjea is fo much con- centrated in them, that a fmall variation in this refpea is not ea- fily diftinguifhed ; but we can readily dilute them to any aflign. able degree. A drop of the oil may be diffolved in fpirit of wine, or received on a bit of fugar, and diffolved by that inter- medium in water. The quantity of liquor which it thus im- pregnates with its flavor, or the degree of flavor which it com- municates to a certain determinate quantity, will be the meafure of the degree of goodnefs of the oil. Volatile oils, medicinally confidered, agree in the general qual- ities of pungency and heat; in particular virtues, they differ as much as the fubjeas from which they are obtained, the oil being the direa principle in which the virtues, or at leaft a confiderable part of the virtues, of the feveral fubjeas refide. Thus the car- minative virtue ot the warm feeds, the diuretic of juniper berries, the emmenagogue of favin, the nervine of rofemary, the fto- machic of mint, the antifcorbutic of fcurvy grafs, the cordial of aromatics, &c. are fuppofed to be concentrated in their oils. There is another remarkable difference in volatile oils, the foun- dation of which is lefs obvious, that of the degree of their pun- gency and heat. Thefe are by no means in proportion, as might be expeaed, to thofe ot the fubjea they were drawn from. The oil ot cinnamon, for inftance, is exceffively pungent and fiery ; in its undiluted ftate it is almoft cauftic ; whereas cloves, a fpice which in fubftance is far more pungent than the other, yields an oil which is far lefs fo. This difference feems to depend partly upon the quantity of oil afforded, cinnamon yielding much lefs than cloves, and confequently having its aaive matter concen- trated into a fmaller volume ; partly, upon a difference in the na- ture of the aaive parts themfelves ; for though volatile oils con- tain always the fpecific odor and flavor of their fubje£ls, wheth- er grateful or ungrateful, they do not always contain the whole pungency ; this refides frequently in a more fixed refinous mat- ter, and does not rife with the oil. After the diftillation of cloves, pepper, and fome other fpices, a part ot their pungency is found to remain behind ; a fimple tinaure ot them in reaified fpirit of wine is even more pungent than theirpure effential oils. The more grateful oils, are frequently made ufe of for recon- ciling to the ftomach medicines ot themfelves difguftful. It has been cuftomary to employ them as coneaors tor the refinous pur- gatives ; an ufe which they do not feem to be Veil adapted to. All the fervice they can here be of, is, to make the refin fit mor Chap. XXL] Empyreumatic Volatile Oils. 51? eafily at firft on the ftomach ; far from abating the irritating qual- ity upon which the violence ot its operation depends, thefe pun- gent oils fuperadd a frefh ftimulus. Volatile oils are never given alone, on account of their extreme heat and pungency ; which in fome is fo great, that a fingle drop let fall upon the tongue, produces a gangrenous efchar. They are readily imbibed by pure dry fugar, and in this form may be conveniently exhibited. Ground with eight or ten times their weight of fugar, they become foluble in aqueous liquors, and thus may be diluted to any affigned degree. Mucilages alfo render them mifcible with water into an uniform milky liquor. They diffolve likewife in fpirit of wine ; the more fragrant in an equal weight, and almoft all of them in lefs than lour times their own quantity. Thefe folutions may be either taken or. r?gar, or mix- ed with fyrups, or the like. On mixing them with water, the li- quor grows milky, and the oil feparates. The more pungent oils are employed externally againft para- lytic complaints, numbnefs, pain*, and *ches, cold tumors, and in other cafes where particular parts require to be heated or ffimu- lated. The toothach is fometimes relieved bv a drop of thefe al- moft cauftic oils, received on cotton, and cautioufly introduced into the hollow tooih. CHAP. XXL EMPYREUMATIC VOLATILE OILS. Empyreumatic Oils agree in many particulars with the vol- atile oils already treated of, but they alfo differ from them in fev- eral important circumftances. The latter exift ready formed in the aromatic fubftances, from which they are obtained, and are on- ly feparated from the fix^d principles by the aaion of a heat not exceeding that of boiling water. The former, on the contrarv, are always formed by the aaion of a degree of heat confiderably higher than that of boiling water, and are the produa of decom- pofition, and a new arrangement ot the elementary principles of fubftances, containingat leaft oxygen, hydrogenand carbon. Their produaion is therefore always attended with the formation of oth- er new produas. In their chemical properties they do not differ very remarkably from the volatile oils, and are principally dif- tinguifhed from them by their unpleafant pungent empyreumat- ic fmell, and rough bitterifli tafte. They are alfo more apt ta 516 Preparations and Compositions. [Part III. fpoil by the contaa of the air, and the oftener they are rediftilled they become more limpid, lefs colored, and more foluble in alco- hol ; whereas the effential oils, by repeated diftillations, become thicker, and lefs foluble in alcohol. Their aaion on the body is exceedingly ftimulant and heating. OLEUM PETROLEI. Lond. Oil of Petroleum. Diftil petroleum in a fand bath. The oil obtained from this bitumen will be more or lefs thin according to the continuance of the diftillation ; and by its con- tinuance, the tar will at laft be reduced to a black coal; and then the oil will be pretty deep in color, but perfeaiy fluid, though very acrid and ftimulating. It is lefs difagreeable than fome of the other empyreumatic oils which had formerly a place in our pharmacopceias, fuch as the o- leum lateritium. OLEUM SUCCINI PURISSIMUM. Edin. Purified Oil of Amber. Diftil oil ot amber in a glafs retort with fix times its quantity of water till two thirds of the water have paffed into the receiver ; then feparate this very pure volatile oil from the water, and keep it for ufe in clofe fhut veffels. Oleum Succini Rectificatum. Lond. Reclified Oil of Amber. Take of Oil of amber, one pound. Diftil three times. Dub. Take of The oil which rifes in the preparation of fait of amber, three pounds. Diftil a pound and a half. The feaifiedoil has a ftrong bituminous fmell, and a pungent acrid tafte. Given in a dofe of ten or twelve drops, it heats, ftimulates, and promotes the fluid fecretions : It is chiefly cele- brated in hyfterical diforders, and in deficiences of the uterine purgations. Sometimes it is ufed externally, in liniments for weak or paralytic limbs and rheumatic pains. / Qhap, XXL] Of Empyreumatic Oils. 517 OLEUM ANIMALE. Lond. Animal Oil. Take of Oil of hartfhorn, one pound. Diftil three times. OLEUM CORNU CERVINI RECTIFICATUM. Dub. Ritlified Oil of Hartffiorn. Take of The oil of which afcends in the diftillation of the volatile liquor of hartfhorn three pounds. Water, fix pounds. Diftil a pound and a half. Animal Oil, thus reaified, is thin and limpid, of a fubtle, penetrating, not difagreeable fmell and tafte. It is ftrongly re- commended as an anodyne and antifpafmodic in dofes of from 15 to 30 drops. Hoffman reports, that it procures a calm and fweet fleep, which continues often from 20 hours, without being fol- lowed by any languor or debility, but rather leaving the patient more alert and cheerful than before ; that it procures likewife a gentle fweat, without increafing the heat of the blood ; that giv- en to 20 drops or more, on an empty ftomach fix hours before the acceffion of an intermittent fever, it frequently removes the diforder ; and that it is likewife a very general remedy in invete- rate and chronical epilepfies, and in convulfive motions, efpecial- ly if given before the ufual time of the attack, and preceded by proper evacuations. How far empyreumatic oils poffefs the virtues that have been afcribed to them, has not yet been fufficiently determined by ex- perience ; the tedioufnefs and trouble of the reaification having prevented their coming into general ufe, or being often made. They are liable alfo to more material inconvenience in regard to their medicinal ufe, namely, precarioufnefs in their quality ; for how perfeaiy foever they may be reaified, they gradually lofe, in keeping, the qualities they had received from that procefs, and return more and more towards their original fetid ftate. 518 Preparations and Compositions. [Part III. CHAP. XXII. DISTILLED SPIRITS. The flavor and virtues of diftilled waters are owing, as obferv- ed in the preceding chapter, to their being impregnated with a por- tion of the effential oil of the fubjea from which they are drawn. Alcohol, confidered as a vehicle for thefe oils, has this advantage above water, that it keeps all the oil that rifes with it perfeaiy diffolved into an uniform limpid liquor. Neverthelefs, many fubftances, which, on being diftilled With water, impart to it their virtues in great perfeaion ; if treated in the fame manner with fpirit ot wine, fcarcely give over to it any fmell or tafte. The caufe of this difference is, that fpirit is not fufceptible of fo great a degree of heat as water. It is obvious, therefore, that fubftances may be volatile enough to rife with the heat of boiling water, but not with that of boiling fpirit. Thus, if cinnamon, for inftance, be committed to diftillation with a mixture of fpirit of wine and water, or with a pure proof fpirit, which is no other than a mixture of about equal parts of the two; the fpirit will arife firft clear, colorlefs and tranfparent, and almoft without any tafte of the fpice ; but as foon as the more ponderous watery fluid begins to arife, the oil comes freely over with it, fo as to render the liquor highly odorous, fapid, and of a milky hue. The proof fpirits ufually met with in the fhops are accompan- ied with a degree of ill flavor ; which, though concealed by means of certain additions, plainly difcovers itfelf in diftillation. This naufeous flavor does not begin to arife till after the purer fpirit- uous part has come over ; which is the very time that the virtues of the ingredients begin alfo moft plentifully to diftil; and hence the liquor receives an ungrateful taint. To this caufe principally is owing the general complaint, that the cordials of the apotheca- ry are lefs agreeable than thofe of the fame kind prepared by the diftiller ; the latter being extremely curious in reaifying or pu- rifying the fpirits (when defigned for what he calls fine goods)' from all unpleafant flavor. SPIRITUS CARI CARVI. Edin. Spirit of Caraway. Take of Caraway feeds, half a pound ; Chap. XXII.] Of Distilled Spirits. 519 Diluted alcohol, nine pounds. Macerate two days in a clofe veffel ; then pour on as much water as will prevent empyreuma, and draw off by diftillation nine pounds. Spiritus Carvi, Lond. Dub. Spirit of Caraway. Take of Caraway feeds, bruifed, half a pound ; Proof fpirit ot wine, one gallon ; (nine pounds, Dub.) Water, fufficient to prevent empyreuma. Draw off one gallon (nine pounds, Dub.) In the fame manner is prepared the fame quantity of Spirit from Spiritus ^ , / LaUri Cinnamomi. Edin. Cinnamon, one pound, \Cinnamomi. Lond. Dub. Peppermint, one pound and. j Mentha Piperita. Edin. a half, \------ Piperitidis. Lond. Spearmint, one pound and a half, Mentha fativa. Lond. Pennyroyal dried, a pound and a half, Pulegii. Lond. Nutmeg, well bruifed, two f Myrifiicx mofchata. Edin. ounces, L Nucis mofchata. Dub. Lond. , ,r , f Myrti Pimenta. Edin. Pimento, half a pound, \pimento. Dub. Lond. SPIRITUS LAVANDULA SPIC^E. Edin. Spirit of Lavender. Take of Flowering fpikes of lavender, frefh gathered, two pounds ; Alcohol, eight pounds. Draw off by the heat of boiling water, feven pounds. Spiritus Lavenpula. Lond. Dub. Spirit of Lavender. Take of Frefh flowers of lavender, one pound and a half ; Proof fpirit of wine, one gallon (nine pounds, Dub.) Draw off by diftillation in a water bath, five pints (five pounds, Dub.) 520 Preparations and Compositions. [Fart III. By thefe direaions, and in the fame quantities are prepared, SPIRITUS RORISMARINI OFFICINALIS. Edin, Spiritus Rorismarini. Lond. Spirit of Rofemary, from two pounds of the flowering tops of rofemary, according to the Edinburgh College, and from a pound and a half according to the London. We think it unneceffary to make particular obfervations on each of thefe fimple fpirits, as their virtues are the fame with thofe of the fubftances from which they are extraaed, united to the ftimulus of the alcohol. The alcohol in the fpirits of laven- der and rofemary, is almoft pure ; in the others it is diluted with about an equal weight of water. SPIRITUS ANISI COMPOSITUS. Lond. Compound Spirit of Anifeed. • Take of Anifeed, Angelica feed, of each, bruifed, half a pound ; Proof fpirit, one gallon ; Water, fufficient to prevent empyreuma. Draw off one gallon by diftillation. This compound fpirit, like the fimple ones, is an agreeable cordial ; indeed too agreeable, for by fome they are fo often re- forted to, on the flighteft fenfation of flatulence in the ftomach, that their ufe is attended with all the pernicious confequences of dram drinking. SPIRITUS JUNIPERI COMMUNIS COMPOSITUS. Edin. Spiritus Juniperi Compositus. Lond. Dub. Compound Spirit of Juniper. Take of Juniper berries, well bruifed, one pound ; Caraway feeds, Sweet fennel feeds, each one ounce and a half; Diluted alcohol, nine pounds, (one gallon Lond.) Water fufficient to prevent empyreuma. (Macerate two days, Edin.) Draw off nine pounds, (one gallon, Lond.) The good and bad effeas of this fpirit exaaiy coincide with thofe of gin. Chap. XXII.] Of Distilled Spirits. 521 SPIRITUS RAPHANI COMPOSITUS. Lond. Dub. Compound Spirit of Horfe Radifli. Take of Frefh horfe radifli root, Dried outer rind of Seville oranges, each two peunds; Frefh herb of garden fcurvy grafs, four pounds; Bruifed nutmegs, one ounce ; Proof fpirit, two gallons, (eighteen pounds, Dub.) Water fufficient to prevent empyreuma. v Draw off two gallons, (eighteen pounds, Dub.) Although this procefs may furnifh an agreeable compound fpirit, yet it is much to be doubted, whether it poffeffes thofe an- tifcorbutic powers for which it was once celebrated. SPIRITUS AMMONLE FCETIDUS. Lond. Fetid Spirit of Ammonia. Take of Proof fpirit, fix pints ; Sal ammoniac one pound ; Afafcetida, four ounces. Potafh, one pound and a half. Mix them, and draw off by diftillation five pints with a flow fire. Edin. Alcohol Ammoniatum Fcetidum. Dub. Fetid Spirit of Volatile Alkali. Take of Spirit of ammonia, eight ounces, (ten ounces, Dub.) Afafcetida, half an ounce. Digeft in a clofe veffel twelve hours; then diftil off, with the heat of boiling water, eight ounces. This fpirit, the laft formula of which is the beft, as being moft eafily prepared, is defigned as an antihyfteric, and is undoubtedly a very elegant one. Volatile fpirits impregnated for thefe pur- pofes with different fetids, have been ufually kept in the fhops ; the ingredient here chofen, is the beft calculated of any for gen- eral ufe, and equivalent in virtue to them all. The fpirit is pale when newly diftilled, but acquires a confiderable tinge by keep- ing. 522 Preparations and Compositions. [Part III. CHAP. XXIIL INFUSIONS. We have already (178, S. 2.) explained the fenfe in which we employ the term infufion. We confine it to the aaion of a men- ftruum not affifted by ebullition, on any fubftance confifting of heterogeneous principles, fome of which are foluble, and others infoluble, in that menftruum. The term is generally ufed in a more exrenfive, but we are inclined to think, a lefs correa fenfe. Thus, lime water and the mucilages, which are commonly claffed with the infufions, are inftances of fimple folution, and the chalk mixture is the mechanical fufpenfion of an infoluble fubftance. When the menftruum ufed is water, the folution is termed fimply an Infufion ; but when the menftruum is alcohol, it is called a Tinaure ; when wine or vinegar, a Medicated Wine or Vinegar. Infufions in water are extremely apt to fpoil, and are generally extemporaneous preparations. INFUSUM CINCHONA OFFICINALIS. Edin. Infufion of Cinchona Bark. Take of Peruvian bark in powder, one ounce ; Water, one pound. Macerate for twentyfour hours, and filter. Infusum Corticis Peruviani. Dub. Infufion of Peruvian Bark. Take of Peruvian bark in coarfe powder, one ounce ; Mucilage of gum arabic, two ounces ; Water, twelve ounces. Triturate the bark with the mucilage, and add the water during the trituration. Macerate for twentyfour hours, and decant the pure liquor. This is a very elegant form of exhibiting the aaive principles of Cinchona bark, and that in which it will fit lighteft on weak and delicate ftomachs. The trituration direaed by the Dublin College will promote the folution, and the addition of the mucil- ♦ Chap. XXIII.] Of Infusions. 525 lage, will fufpend the fineft particle's of the fubftance of the bark itfelf. The refiduum of the cold infufion may be afterwards em- ployed in making other preparations, efpecially the extraa, for its virtues are by no means exhaufted. But it muft never be dri* ed and fold, or exhibited in fubftance, for that would be a culpa- ble fraud. INFUSUM DIGITALIS PURPUREA. Edin. Infufion of Foxglove. 1 Take of Dried leaves of foxglove, one drachm J Boiling water, eight ounces ; Spirit of cinnamon, one ounce. Macerate for four hours, and filter. This is the infufion fo highly recommended by Withering. Half an ounce, or an ounce of it, may be taken twice a day in dropfical complaints. The fpirit of cinnamon is added to improve its flavor, and to counteraa its fedative effeas. INFUSUM GENTIANS LUTEAL COMPOSITUM 5 vulgo, Infusum Amarum. Edin. Compound Infufion of Gentiani or Bitter Infufion. Take of Gentian root, half an ounce ; Dried peel of Seville oranges, one drachm j Coriander feeds, half a drachm ; Diluted alcohol, four ounces; Water, one pound. Firft pour on the alcohol, and three hours thereafter add the wa- ter ; then macerate without heat for twelve hours, and ftraim Infusum Gentiana Compositum." Lend. Compound Infufion of Gentian. Take of The root of gentian cut into pieces, one drachm ; Dried orange peel, a drachm and a half ; Frefh outer rind of lemons, half an ounce ; Boiling water, twelve ounces by meafure. Macerate for an hour, and ftrain. Take of Bruifed gentian root, two drachms; Frefh outer rind ot lemons, half an ounce ; Dried peel of Seville oranges, a drachm and a half j 524 Preparations and Compositions. [Parti"- Diluted alcohol, four ounce^ ; Boiling water, twelve ounces. Firft pour on the fpirit, and after three hours, the water. Laftly, after macerating two hours, filter. These formulae do not differ materially. The Edinburgh Col- lege employ the largeft proportion of gentian ; but they infufe it in cold water, which does not extraa the bitter principle fo quick- ly or fo fully as boiling water, although it diffipates lefs of the flavor of the aromatics. The alcohol is a ufeful addition, both in promoting the extraaion of the virtues of all the ingtedients, and in preferving the infufion longer from fpoiling. This infufion is an extremely good bitter; and is of great fervice in all cafes where bitters in general are neceffary. It ftrengthens the ftomach, and increafes the appetite ; befides aaing as a tonic on the other parts of the body, and on the vafcular fyftem. INFUSUM MIMOSjE CATECHU; vulgo, Infusum Ja- ponicum. Edin. Infufion of Catechu, commonly called Japonic Infufion. Take of Extrafcl of catechu, two drachms and a half ; Cinnamon,'half a drachm ; Boiling water, feven ounces ; Simple fyrup, one ounce. Macerate the extraa and cinnamon in the hot water, in a covered veffel, for two hours ; then ftrain it, and add the fyrup. Extract of catechu is almoft pure tanin. This infufion is therefore a powerfully aftringent folution. The cinnamon and fyrup render it a very agreeable medicine, which will be found ferviceable in fluxes proceeding from a laxity of the inteftines. Its dofe is a fpoonful or two every other hour. INFUSUM RHEI PALMATE Edin. Infufion of Rhubarb. Take of Rhubarb, half an ounce ; Boiling water, eight ounces ; Spirit of cinnamon, one ounce. Macerate the rhubarb in a clofe veffel with the water, for twelve hours ; then having added the fpirit, ftrain the liquor. This appears to be one of the beft preparations of rhubarb, when defigned as a purgative ; water extraaing its virtue more effeaually than either vinous or fpirituous rnenftrua. Chap. XXIII.] Of Infusions^ 525 INFUSUM ROS.E. GALLIC/E. Edin. Infufion of Rofes. n Take of The petals of red rofes, dried, one ounce ; Boiling water, five pounds ; Sulphuric acid, one drachm ; White fugar, two ounces. Macerate the petals with the boiling water in an earthen veffel, which is not glazed with lead, for four hours ; then having poured on the acid, ftrain the liquor, and add the fugar. Infusum Rosa. Lond. ——-~ Infufion of Rofes, Take of Dried red rofes, half an ounce ; Diluted vitriolic acid, three drachms ; Boiling diftilled water, two pints and a half; Double refined fugar, one ounce and a half. Firft pour the water on the petals in a glafs veffe'l, then add the diluted vitriolic acid, and macerate for half an hour. Strain the liquor, when cold, and add the fugar. Infusum Rosarum ; olim, Tinctura Rosarum. Dub. Infufion of Rofes, formerly Tinclure of Rofes. Take of The petals of red rofe buds, half an ounce ; Diluted vitriolic acid, three drachms ; Boiling water, three pounds; Double refined fugar, an ounce and a half. Firft mix the acid with the water in a glafs or glazed earthen vef- fel. Macerate the petals in the mixture, then add the fugar to the liquor when cold and ftrained. The difference in the direaions for preparing this infufion are immaterial. In fail, the rofe leaves have very little effea, ex- cept in giving the mixture an elegant red color. Its fubacid and aftringent virtues depend entirely on the fulphuric acid. Alto- gether, however, it is an elegant medicine, and forms a very grate- ful addition to juleps in haemorrhagies, and in all cafes which re- quire mild coolers and fubaftringents ; it is fometimes taken with bolufes or eleauaries of the bark, and likewife makes a good gargle. ICT2 S26* Preparations and Compositions. [Part IlL INFUSUM SENN^fL SIMPLEX. Lond. Simple Infufion of Senna. Take of Senna, an OHmie and a half ; Ginger, powdered, one drachm ; Boiling diftilled water, one pint. Macerate them for one hour, in a covered veffel ; and ftrain the1 liquor when cold. Infusum Senn^e. Dub. Infufion of Senna. Take of Senna, fix drachms ; Ginger, powdejed, half a drachm ; Boiling water, ten ounces. Macerate them for an hour in a covered veffel, then filter. This is a very elegant infufion of fenna, the ginger aaing as an ufeful corrigent. But if the fenna were employed to the quantity ofa drachm and a half, or two drachms only, in place, of the quan- tity here ordered, it would be more convenient, as it is of advan- tage that it fhould be ufed frefh as here prepared. Of the prefent infufion, an ounce or two is a fufficient dofe. INFUSUM SENN.E TARTARISATUM. Lond. Tartarifed Infufion of Senna, Take of Senna, one ounce and a half; Coriander feeds, bruifed, half an ounce \ Cryftals of tartar, two drachms ; Diftilled water, one pint. Diffolve the cryftals of tartar by boiling in the water; then pour the liquor, as yet boiling, on the fenna and feeds. Macerate for an hour in a covered veffel, and ftrain when cold. The addition of fupertartrite of potafs renders the tafte of the fenna lefs unpleafant, and alfo promotes its aaion. INFUSUM TAMARINDI INDICI cum CASSIA SENNA, Edin. Infufion of Tamarinds and Senna, Take of Preferved tamarinds, one ounce ; Senna, one drachm ; Coriander feeds, halt a drachm ; Chap. XXIV,] Of Decoctions, *?27 Brown fugar half an ounce ; Boiling water, eight ounces. Macerate them for four hours, occafionally agitating them, in a clofe earthen veffel, not glazed with lead, and ftrain the liquor. It may alfo be made with double, triple, &c. the quantity of fe-ina. This forms a mild and ufeful purge, excellently fuited for del" icate ftomachs, and inflammatory difeafes. The tafte of the fenna is well covered by the aromatic fugar and by the acidity pf the tamarinds. CHAP. XXIV. DECOCTIONS. Decoctions differ from infufions only in theaaipnof the menftruum being affifted by a boiling heat. At the fame time, however, that the increafe of temperature facilitates and expedites the folution of fome fixed principles, it gives others a tendency to decompofition, and diffipates all volatile matters. Decoaion, therefore, can only be ufed with advantage for the extraction of principles which are neither volatilized nor altered by boiling beat, DECOCTUM ALTHjE^E OFFICINALIS. Edin. Decocliou of Marfhmallows. Take of Dried marfhmallow roots, four ounces; Raifins of the fun, ftoned, two ounces ; Water, feven pounds. Boil to five pounds ; place apart the fti lined liquor till the feces have fubfided, then pour off the clear liquor. Marshmallow roots contain nothing foluble in wafer,.ex- cept mucilage, which is very abundant in them. This decoaion is therefore to be confidered merely as an emollient, rendered more pleafant by the acidulous fweetnefs of the wrtTins. C3-.3 528 Preparations' and Compositions. [Pait. III. DECOCTUM ANTHEMIDIS NOBILIS; vulgo, Dfcoc- tum Chamameli five Commune. Edin. Common DecoBion, or DecoBion of Camomile. Take of Camomile flowers, dried, one ounce ; Caraway feeds, half an ounce ; Water, five pounds. Boil a quarter of an hour, and ftrain. Decoctum Cham/emeli ; five, Decoctum pro Ene- MATE. Dub. Decoclion of Camomile, or Decoclion for Clyfters. Take of Camomile flowers, dried, half an ounce ; Sweet fennel feeds, two drachms ; Water, a pound. Boil a little, and ft*ain. Decoctum pro Enemate. Lond. DecoBion for Clyfters. Take of The leaves of mallow, dried, one ounce ; Camomile flowers, dried, half an ounce ; Water, one pint. Boil and ftrain. Decoctum pro Fomento, Lond. DecoBion for Fomentations. Take of The leaves of fouthernwood, dried, The tops of fea wormwood, dried, Camomile flowers, dried, each one ounce ; Bay leaves, dried, half an ounce ; Diftilled water, fix pints. Boil them a little, and ftrain. These decoaions are merely folutions of bitter extraaive, combined, in the third, with mucilage, and in the others with ef- fential oils. \n making them, the aromatic fubftances fhould not be added until the decoaion is nearly completed ; for other- wife their flavor would be entirely diffipated. It muft however be acknowledged, that thefe impregnations are for the moft part unneceffdry for the purpofe of clyfters ; and in prdinary cafes, the bulk and warmth produce a difcharge before $hefe medicines can have any effea. Chap. XXIV.] Of Decoctjons, 529 As fomentations, their virtues are alfo in a -great meafure to be afcribed to the influence of the warm water ; and when the herbs themfelves are applied, they aa only as retaining heat and moifture for a longer time. DECOCTUM C1NCHON.-E OFFICINALIS; vulgo, De- coctum Corticis Peruviani. Edin. D:coBion of Cinchona Bark. Take of Cinchona bark, in powder, one ounce ; Water, a pound and a halt. Boil for ten minutes in a covered veffel, and ftrain the liquor while hot. , Decoctum Corticis Peru'viani. Lond. DecoBion of Peruvian Bark. Take of Peruvian bark, powdered, one ounce ; Diftilled water, one pint and three ounces. Boil for ten minutes in a covered veffel, and ftrain the liquor while hot. Dub. Take of Peruvian bark, in coarfe powder, fix drachms; Water, eighteen ounces. Boil for ten minutes in a veffel almoft covered, and ftrain the li- quor, while hot, through linen. Cinchona bark readily yields its aaive principles to the ac- tion of boiling water, and in greater quantity than cold water is capable of retaining diffolved ; therefore, when a faturated decoc- tion cools, it becomes turbid, and there is always a depofition of a yellowiffi or reddifh powder, while the fupernatant liquor is re- duced to the ftrength of a faturated cold infufion. Decoclion therefore, prefents us with an eafy means of obtaining immediately an aaive preparation of cinchona bark, and with.one ot greater ftrength than a cold or even a warm infufion, provided it be drunk while tepid, and before it forms any depofition, or if the precipi- tate be diffufed by agitation, after it is formed. As the precipi- tate contains no wooden fibre, or other inert matter, it is extrema- )y probable that in very fmall dofes it would j^rove, if dried, a very powerful preparation of cinchona bark. Formerly it was fuppofed that the ftrength of a decoaion of cinchona bark, and fimilar fubftances, was increafed by continuing the boiling for a great length of time ; but this is now known to JC7" 4 530 Preparations and Compositions. [Part III. be a rniftake ; and indeed, after a certain time, the decoaion be- comes weaker inftead of ftronger, becaufe water at different tem- peratures is capable of diffolving only a determinate proportion of their aaive principles ; and therefore, as foon as it is faturated, any further decoaion is unneceffary. But moreover, thefe prin- ciples, when diffolved in water, are liable to be decompofed and become inert, by the abforption of atmofpheric oxygen, and this decompofition is increafed by increafe of temperature ; and as boiling conftantly prefents new furfaces to tbe aaion of the air, it is evidently hurtful when protraacd longer than what is juft ne- ceffary to faturate the water. Ten minutes is fuppofed by the Colleges to be fufficient for that purpofe. DECOCTUM DAPHNES MEZFREI. Edin. DecoBion of Mezereon. Take of The bark of Mezereon root, two drachms; Liquorice root, bruifed, half an ounce ; Water, three pounds. Boil it with a gentle heat, down to two pounds, and ftrain it. From four to eight ounces of this decoaion may be given four times a day, in fome obftinate venereal and rheumatic affeaions. It operates chiefly by perfpiration. DECOCTUM GEOFFRiE^E INERMIS. Edin. DecoBion of Cabbage tree bark. Take of Bark of the cabbage tree, powdered, one ounce ; Water, two pounds. Boil it with a gentle fire down to one pound, and ftrain. This is a powerful anthelmintic. It may be given in dofes of one table fpoonful to children, and tour to adults. If difagree- able fymptoms fhould arife from an over dofe, or from drinking cold water during its aaion, we muft immediately purge with caf- tor oil, and dilute with acidulated drinks. DECOCTUM GUAIACI OFFICINALIS COMPOSITUM; vulgo, Decoctum Lignorum. Edin. Compound Decision of Guaiac um, commonly called DecoBion of the Woods. Take of Guaiacurn rafpings, three ounces; Raifins, ftoned, two ounces ; Saffafras root, Chap. XXIV.] Of Decoctions. , 531 Liquorice, each one ounce ; Water, ten pounds. Boil the guaiacum and raifins with the water, over a gentle fire, to tbe confumption of one half ; adding, towards the end, >*•> faffafras and liquorice. Strain the liquorice, without expreffion. This decoaion is of ufe in fome rheumatic and cutaneous af- feaions. It may be taken by itfelf, to th« quantity of a quarter of a pint twice or thrice a day, or ufed as an afliftant in a courfe of mercurial or antimonial alteratives ; the patient, in either cafe, keeping warm, in order to promote the cperation of the medicine. DECOCTUM HELLEBORI ALBI. Lond. DecoBion of White Hellebore. Take of The root of white hellebore, powdered, one ounce ; Diftilled water, two pints ; Reaified fp'nit of wine, two ounces. Boil the water with the root to one pint, and, the liquor being cold, and ftrained, add to it tfie fpirit. This decoaion is only ufed externally as a wafh, in tinea capi- tis, lepra, pfora, &c. When the fkin is very tender and irritable; it fhould be diluted with an equal quantity of water. DECOCTUM HORDEI DISTICHI. Edin. Decoctum Hordei. Lond. DecoBion of Barley. Barley Water. Take of Pearl barley, two ounces ; Water, five pounds. Firft wafh the barley from the mealy matter that adhere« to it, with fome cold water ; then boil it a little with ahout half a pound of water, to extraa the coloring matter. Throw this away; and put the barley thus purified into five pounds of boil- ing water, which is to be boiled down to one half, and ftrained. DECOCTUM HORDEI COMPOSITUM. Lond. Compound DecoBion of Barley. Take of The decoaion of barley, two pints ; Figs, fliced, two ounces; Liquorice root, fliced and bruifed, half an ounce ; Raifins, ftoned, two ounces ; Diftilled water, oue pint. Boil to two pints, and ftrain. 532 Preparations and Compositions. [Part. III. These liquors are to be ufed freely, as diluting drinks, in fe- vers and other acute diforders; hence it is of confequence that they fhould be prepared fo as to be as elegant and agreeable as poffible; fof this reafon they are inferted in the Pharmacopoeia, and the fev- eral circumftances which contribute to their elegance fet down ; if any one of them be omitted, the beverage will be lefs grateful. However trivial medicines of this clafs may appear to be, they are of greater importance in the cure of acute difeafes than many more elaborate preparations. Barley water, however, is much more frequently prepared by nurfes than apothecaries, particularly in its fimple ftate. DECOCTUM POLYGAL^E SENEGA. Edin. DecoBion of Seneka. Take of Seneka root, one ounce ; Water, two pounds. Boil to fixteen ounces, and ftrain. The virtues of this decoaion will be eafily underftood from thofe of the root from which it is prepared. The dofe in hydro- pic cafes, and rheumatic or arthritic complaints, is two ounces, three or four times a day, according to its effea. DECOCTUM SMILACIS SARSAPARILL^E, Edin. Decoctum Sarsaparilla. Lond. Dub. DecoBion of Sarfaparilla, Take of The root of farfaparilla, fliced, fix ounces ; Diftilled water, eight pints. Macerate for two hours, with a heat of about 1950 ; then take out the root, and bruife it ; return the bruifed root to the liquor, and again macerate it for two hours. Then, the liquor being boiled to the meafure of four pints, prefs it out and ftrain. The above formula is that of the London College ; and as that of the Edinburgh College differs from it only in omitting the fe- cond maceration, and that of the Dublin in not expreffing the tem- perature in which it is to be performed, we thought it unne- ceffary to introduce them. It is indeed a very doubtful reme- dy, and its diaphoretic effeas are probably owing to its being drunk warm. It is totally incapable of curing fyphilis; but by fome it is thought ufeful in the fequelae of that difeafe. Chap. XXIV.] Of Decoctions. 533 DECOCTUM SARSAPARILLjE COMPOSITUM. Lond. Dub. Compound DecoBion of Sarfaparilla. 7"ake of The root of farfaparilla, fliced and bruifed, fix ounces ; Bark of the root of faffafras, Shavings of guaiacum wood, Liquorice root, bruifed, of each one ounce ; M-zereen, three drachms ; Diftilled water, ten pints. Micerate, with a gentle heat, for fix hours ; then boil it down to five pints, adding, towards the end of the boiling, the mezereon, and ftrain the liquor. The direaions of the Dublin College only differ in adding the liquorice root along with the mezereon, and in reducing the quantity of the ingredients ufed to one fourth part. This compound decoaion is an elegant mode of preparing an article once highly celebrated under the title of the Lifbon diet drink, which for a long time after its firft introduaion into Bri- tain, was kept a fecret ; but an account of the method of prepar- ing it was at length publifhed in the Phyfical and Literary Effays of Edinburgh, by Dr. Donald Monro. It operates as a diaphoretic, and may be given with advantage in rheumatic cafes, and in fome of the fequelae of fyphylis. Three or four ounces may be taken four times a day. DECOCTUM ULMI. Lond. DecoBion of Elm. Take of The frefh inner bark of elm, bruifed, four ounces; Diftilled water, four pints, Boil to two pints, and ftrain. It has been chiefly, if not entirely, under this form of decoaion, that the elm bark has been employed for combating thofe cutane- ous eruptions, againft which it has of late been fo highly celebrat- ed. Any experience which we have had ot it, however, in aaual praaice, by no means confirms the very favorable account which fome have given of its ufe. 234 Preparations and Compositions. [Part IIT. CHAP. XXV, MUCILAGES. MUGILAGO AMYLL Edin. Lond. Mucilage of Starch. Take of Starch, half an ounce ; Water, one pound. Triturate the ftarch, gradually adding the water ; then boil them, a little. The London College ufe only three drachms of ftarch to one pound of water. The mucilage thus formed is very ufeful in thofe cafes where a glutinous fubftance is required ; it is often fuccefsfully employed as a glyfter, in diarrhoeas depending on ac- rimony in the inteftines. MUCILAGO ASTRAGALI TRAGACANTH^. Edin. Mucilage of Gum Tragacanth. Take of Gum tragacanth, in powder, one ounce ; Boiling water, eight ounces. Macer-ate twentyfour hours ; then triturate them carefully, that the gum may be diffolved ; and prefs the mucilage through linen cloth. Mucilago Traga: antha. Lond. Mucilage of Tragac i ntk. Xake of Tragacanth, half an ounce ; Diftilled water, ten ounces, by meafure. Macerate them, with a gervtle heat, till the tragacanth be diffolvei. Chap. XXV.] Of Mucilages. *$$ Mucilago Cuwmi Tragacanth^:. Dub. Mucilage of Tragacanth. Take of Gum tragacanth, in powder, one drachm ; Boiling water, eight ounces. Diffolve the gum by digeftion ;* then ftrain the mucilage through linen. Gum Tragacanth is difficultly foluble in water. When macerated in it, it fwells, but does not diffolve. To effea the folution it muft be beaten into a pafte with fome of the water « and the reft of the water muft be added gradually, and incorpo- rated with the pafte by beating them together. Gum tragacanth 1S a very tenaceous fubftance, and requires a very large propor- tion of water to form a fluid mucilage. That of the Edinburgh College, which is made with eight parts of water, is a pdik rath- •r than a mucilage. The London mucilage is made with twenty parts of water, and the Dublin with fixty four. MUCILAGO MIMOSA NILOTIC^. Edin. Mucilage of Gum Arabic Take of Gum Arabic in powder, one part ; Boiling water, two parts. Digeft with frequent agitation, until the gum be diffolved ; then prefs the mucilage through linerii Mucilago Arabici Gummi. Lond. Mucilage of Gum Arabic. Take of Gum Arabic, in powder, four ounces ; Boiling diftilled water, eight ounces. Triturate the gum with the water until it be diffolved. Dub. fake of Gum Arabic, in powder, four ounces ; Boiling water nine ounces. Triturate the gum with the water, then prefs the mucilage through linen. It is very neceffary to pafs the mucilage through linen, in or- der to free it from pieces of wood and other impurities, which al- ways adhere to the gum ; the linen may be placed in a funnel. 536 Preparations and Compositions. [Part IIId Mucilage of gum arabic is very ufeful in many operations in pharmacy ; it is alfo much ufed for properties peculiar to thofe fubftances of its own clafs, and of all the gums it feems to be the pureft. MUCILAGO SEMINUM CYDONTI MALI. Lond. Mucilage of Quince Seed. Take of Quince feeds, one drachm ; Diftilled water, eight ounces, by meafure. Boil with a flow fire for ten minutes; then pafs it through linen. This mucilage, though fufficiently agreeable, is perteaiy fu- perfluous, efpecially as it is apt to become mouldy, from being mixed with the other principles of the feeds foluble in water. CHAP. XXVI. s r r u p. s. SYRUPI. Lond. Dub. Syrups. In making fyrups, where we have not direaed either the weight of the fugar, or the manner in which it fhould be diffolved, this is to be the rule : Take of Double refined fugar, twenty nine ounces ; Any kind of liquor, one pint. Diffolve the fugar in the liquor, in a water bath ; then fet it afide for twenty four hours; take off the fcum, and pour off the fyr- up from the feces it there he any. Th e above rule is prefixed to the chapter on fyrups in the Lon- don Pharmacopoeia, and alfo in that of Dublin, except that the latter defire a pound and a half of the prefcribed liquor to be ta- ken, and the folution to be boiled down to one pound before it be fet afide. Chap. XXVI.] Of'Syrups. 537 SYRUPUS SIMPLEX, sive COMMUNIS. Edin. Simple or Common Syrup. Take of Double refined fugar, fifteen parts ; Water, eight parts. Let the fugar be diffolved by a gentle heat, and boiled a little, To as to form a fyrup. This preparation is a plain liquid fweet, void of flavor or co- lor ; and is more convenient in extemporaneous prefcription than fugar undiffolved. SYRUPUS AC1DI ACETOSI. Edin. Syrup of Acetous Acid. Take of Acetous acid, two pounds and a half; Double refined fugar, three pounds and a half. Boil them fo as to form fyrup. This is to be confidered as fimple fyrup merely acidulated, and is by no means unpleafant. It is often employed in mucilaginous mixtures, and the like ; and, on account of its cheapnefs it is of- ten preterred to fyrup of lemons. SYRUPUS ALLIL Dub. Syrup of Garlic. Take of Garlic, fliced, one pound ; Double refined fugar, four pounds ; Boiling water, two pounds. Macerate them in a clofe veffel for twelve hours ; add to the ftrained liquor the fugar. This is a very difagreeable fyrup ; but when we wifh to ex- traa the virtues of garlic by a watery menftruum it is the beft means we can employ. SYRUPUS ALTHjE^E- OFFICINALIS. Edin. Syrup of Marjhmallow. Take of Freffi marfhmallow roots, one pound ; Water, ten pounds ; • Double refined fugar, four pounds ; Boil the water with the roots to the confumption of one half, and ftrain the liquor, ftrongly expreffing it. Suffer the ftrained li- 538 Preparations and Compositions. [Part IIL quor to reft till the feces have fubfided ; and to thedepureted liquor add the fugar ; then boil fo as to make a fyrup. Syrupus Althaa. Lond. Syrup of Marffimallow. Take of Frefh root of marffimallow, bruifed,one pound ; Double refined fugar, four pounds ; Diftilled water one gallon. Boil the water with the marffimallow root to one half, and prefs out the liquor when cold. Set it by twelve hours ; and after the feces have fubfided,pour off the liquor. Add the fugar, and boil it to the weight of fix pounds. This is merely a mucilaginous fyrup, and is chiefly ufed in nephritic cafes, for fweetening emollient decoaions, and the like. SYRUPUS AMOMI ZINGIBERIS. Edin. Syrup of Ginger. Take of Beat ginger, three ounces ; Boiling water, four pounds ; » Double refined fugar, feven pounds and a half. Macerate the ginger in the water in a clofe veffel, for twenty- four hours ; then to the liquor flrained add the beat fugar, fo as to make a fyrup. Syrupus £ingiberis. Lond. Syrup of Ginger. Take of Ginger, bruifed, four ounces ; Boiling diftilled water, three pints. Macerate for four hours, and ftrain ; then add double refined fu- gar, and make into a fyrup, according to the general prefcrip-i tion. These are agreeable and moderately aromatic fyrups, impreg- nated with the flavor and the virtues of the ginger. SYRUPUS CITRI AURANTIL Edin. Syrup of Orange Peel, Take of The freffi outer rind of Seville oranges, fix ounces j Chap. XXVI.] Of Syrups. 539 Boiling water, three pounds ; Double refined fugar, four pounds. Macerate the rind in the water for twelve hours; then add to the filtered liquor the fugar, in powder, and apply a gentle heat, fo as to form a fyrup. Syrupus Corticis Aurantii. Lond. Dub. Syrup of Orange Peel. Take of Frefh outer rind, of Seville oranges, eight ounces ; Boiling diftilled water, five pints. Macerate for twelve hours, in a clofe veffel ; and, in the ftmined liquor, diffolve double refined fugar to make a fyrup. In making this fyrup, it is particularly neceffary that the fugar be previoufly powdered, and diffolved in the infufion with as gen- tle a heat as poffible, to prevent the exhalation of the volatile parts of the peel. With thefe cautions, the fyrup proves a very ele- gant and agreeable one, poffeffing a great fhare of the fine flavor of the orange peel. SYRUPUS CITRI MEDICI; olim, Syrupus Limonum. Edin. Syrup of Lemons. Take of Juice of lemons, fuffered to ftand till the feces have fubfided, and afterwards ftrained, three parts ; Double refined fugar, five parts. Diffolve the fugar in the juice, fo as to make a fyrup. Syrupus Limonis Succi. Lond. Dub. Syrup of Lemon Juice. Take of Lemon juice, ftrained, after the feces have fubfided, two pints; Double refined fugar, fifty ounces (four pounds, Dub.) Diffolve the fugar fo as to form a fyrup. In the fame way are prepared, SYRUPUS SUCCI FRUCTUS MORI. Lond. Syrup of Mulberry Juice. Syrupus Succi Fructus Rubi Idai. Lond. Syrup qfRqfpberry Juice. L i 540 Preparations and Compositions. [Part III. Syrupus Succi Fructus Ribis Nigri. Lond. Syrup of Black Currant Juice; All thefe are very pleafant cooling fyrups ; and with this in- tention they are occafionally ufed in draughts and juleps, for quenching thirft, abating heat, &c. in bilious or inflammatory diftempers. They are fometimes likewife employed in garga- rifms for inflammations of the mouth and tonfils. SYRUPUS COLCHICI AUTUMNALIS. Edin. Syrup of Colchicum. Take of Colchicum root, frefh and fucculent, cut into fmall pieces, one ounce ; Vinegar, fixteen ounces; Double refined fugar twentyfix ounces. Macerate the root in the vinegar two days, now and then ffiaking the veffel; then ftrain it with a gentle preffure ; to the ftrained liquor add the fugar, and boil a little, fo as to form a fyrup. This fyrup feems to be the beft preparation of the colchicum. We muft take care to gather this root in the proper feafon ; and from errors in this particular we are to afcribe the uncertainty in the effeas of this medicine as found in the fhops. The fyrup of colchicum is often fuccefsfully employed as a di- uretic, and may be taken from a drachm or two to the extent of an ounce or more. SYRUPUS DIANTHI CARYOPHYLM. Edin. Syrup of Clove July Flower. Take of Clove July flowers, frefh gathered and freed from the heels, one pound ; Double refined fugar, feven pounds ; Boiling water, four pounds. Macerate the petals in the water for twelve hours ; then to the ftrained liquor add the fugar previoufly beat, and diffolve it by a gentle heat, fo as to form a fyrup. Syrupus Caryophylli Rubri. Lond. Syrup of Clove July Flower. Take of Frefh clove July flowers, two pounds ; Boiling diftilled water, fix pints. Chap. XXVI.] Of Syrups. 541 Macerate for twelve hours in a glafs veffel; and in the ftrained liquor, diffolve double refined fugar, fo as to form a fyrwp. As the beauty of the color is a principal quality in this fyrup, no force in the way of expreffion fhould be ufed in feparating the liquor from the flowers. Some have fubftituted to it one eafily prepared at feafons when the flowers are not to be procured ; an ounce of clove fpice is in- fufed for fome days in twelve ounces of white wine, the liquor ftrained, and, with the addition of twenty ounces of fugar, boiled to a proper confiftence ; a little cochineal renders the color of this fyrup exaaiy fimilar to that prepared from the above July flower ; and its flavor is of the fame kind, though not fo pleaf- ant. The abufe may be readily deteaed by adding to a little of the fyrup fome alkaline fait or ley ; which will change the gen* uine fyrup to a green color ; but in the counterfeit, it will make no fuch alteration, only varying the ffiade of the red. SYRUPUS CROCI. Lond. Syrup of Saffron. Take of Saffron, one ouncei Boiling diftilled water* one pint. Macerate the faffron, in the water, for twelve hours, in a clofe veffel ; and diffolve double refined fugar in the ftrained liquor, that it may be made a fyrup. Saffron is very well fitted for making a fyrup, as in this form a fufficient dofe of, it is contained in a reafonable compafs, This fyrup is a pleafant cordial, and gives a fine color to juleps. SYRUPUS MANN.E. Dub. Syrup of Manna, Take of Manna, Double refined fugar, each one pound ; Senna half an ounce ; Boiling water, a pound. Macerate the fenna in the water, in a covered veffel, for twelve hours ; then, with the ftrained liquor, mix the manna and the fugar, fo that they may be diffolved. This fyrup is a mild purgative, and well adapted to chil* dren and perfonsofa delicate conftitution. ICP 2 543 Preparations and Compositions. [Part III. SYRUPUS PAPAVERIS SOMNIFERI. Edin. Syrup of White Poppies. Take of White poppy heads, dried, and freed from the feeds, twe pounds ; Boiling water, thirty pounds ; Double refined fugar, four pounds. Macerate the fliced heads in the water for twelve hours ; next boil till only one third part of the liquor remain ; then ftrain it, by expreffing it ftrongly. Boil the ftrained liquor to the confumption of one half, and ftrain again ; laftly, add the fugar, and boil a little fo as to form a fyrup. Syrupus Papaveris Albi. Lond. Syrup of White Poppy. Take of The heads of white poppies, dried, three pounds and a half ; Double refined fugar, fix pounds ; Diftilled water, eight gallons. Slice and bruife the heads, then boil them in the water, to three gallons, in a water bath, faturated with fea fait, and prefs out the decoaion. Reduce this, by boiling to about four pints, and ftrain it while hot, through a fieve, then through a thin woollen cloth, and fet it afide for twelve hours, that the feces may fub- fide. Boil the liquor, poured off from ihe feces, to three pints, and diffolve the fugar in it, that it may be made a fyrup. This fyrup, impregnated with the opiate matter of the poppy heads, is given to children in dofes of two or three drachms ; to adults, from half an ounce to an ounce and upwards, for eafing pain, procuring reft, and anfwering the other intentions of mild opiates. Particular care is requifite in its preparation, that it may be always made, as nearly as poffible, of the fame ftrength ; and accordingly the Colleges have been very minute in their defcrip- tion of the procefs. SYRUPUS OPII. Dub. Syrup of Opium. Take of Extraa of opium, fortyeight grains ; Boiling water, three pounds. Macerate until the opium be diffolved, then add double refined fugar, fo as to make a fyrup according to the general formula. This fyrup is an elegant fubftitute for the former. It is made with infinitely lefs trouble, and is always of an uniform ftrength. It contains about two grains and a half of opium in the ounce. Chap. XXVI.] Of Syrups. 543 SYRUPUS PAPAVERIS ERRATICl. Lond. Syrup of Red Poppey. Take of The freffi flowers of the red poppey, four pounds ; Boiling diftilled water, four pints and a half. Put the flowers, by degrees, into the boiling water, in a water bath, conftantly ftirring them. After this, the veffel being ta- ken out of the bath, macerate for twelve hours; then prefs out the liquor, and fet it apart, that the feces may fubfide. Laftly, make it into a fyrup, with double refined fugar. The defign of putting the flowers into boiling water in a water bath is, that they may be a little fcalded, fo as to fhrink enough to be all immerged in the water ; without this artifice they can fcarce be all got in ; but they are to be continued no longer over the fire than till this effea is produced, left the liquor become too thick, and the fyrup be rendered ropy. As a medicine it is perfeaiy infignificant. SYRUPUS RHAMNI CATHARTICI. Edin. Syrup of Buckthorn. Take of The juice of ripe buckthorn berries, depurated, two parts ; Double refined fugar, one part. Boil them fo as to form a fyrup. Syrupus Spina Cervina. Lond. Syrup of Buckthorn. Take of The freffi juice of ripe buckthorn berries, one gallon ; Ginger, bruifed, one ounce ; Pimento, powdered, one ounce and a half; Deuble refined fugar, feven pounds. Set by the juice for three days, that the feces may fubfide, and ftrain. Macerate the ginger and pimento in a pint of the ftrain- ed juice for four hours, and ftrain. Boil away the reft of the juice to three pints ; then add that part of the juice in which the ginger and pimento have been macerated ; and, laftly, the fugar, that it may be made a fyrup. Both thefe preparations, in dofes of three or four fpoonfuls, operate as brifk cathartics. The principal inconveniences attend. ing them are, their being very unpleafant, and their occafioning a thirft and drynefs of the mouth and fauces, and fometimes violent gripes ; thefe effeas may be prevented by drinking liberally of water gruel, or other warm liquids, during the operation, <&T 3 544 Preparations and Compositions. [Part III. SYRUPUS ROSyE GALLIC^. Edin. Syrup of Red Rofes. Take of The dried petals of red rofes, feven ounces ; Double refined fugar, fix pounds ; Boiling water, five pounds. Macerate the rofes in the water for twelve hours, then boil them a little and ftrain the liquor, add to it the fugar, boil them again for a little fo as to form a fyrup. This fyrup is fuppofed to be mildly aftringent; but is prin- cipally valued on account of its red color. Syrupus Rosa Centifolia. Edin. Syrup of Damaft. Rofes. Take of The frefh petals of the damafk rofe, one pound ; Boiling water, four pounds; Double refined fugar, three pounds. Macerate the rofes in the water for a night ; then to the liquor ftrained, and freed from the dregs, add the fugar ; boil them in- to a fyrup. Syrupus Rosa. Lond. Syrup of Rofes. 1 ake ot The dried petals of the damafk rofe, feven ounces; Double refined fugar, fix pounds ; Boiling diftilled water, four pints. Macerate the rofes in the water for twelve hours, and ftrain. E- vaporate the ftrained liquor to two pints and an half, and add the fugar, that it may be made a fyrup. This fyrup is an agreeable and mild purgative for children, in the dofe of half a fpoonful, or a fpoonful. It likewife proves gently laxative to adults ; and with this intention may be of fer- vice in coftive habits. SYRUPUS SCILLA MARITIME. Edin. Syrup of Squills. Take of Vinegar of fquills, two pounds ; Double refined fugar in powder, three pounds and a half. Diffolve the fugar with a gentle heat, fo as to form a fyrup. Chap. XXVI.] Of Syrups. 545 This fyrup was formerly prepared with fome fpices, intended to diminifh the offenfivenefs of the fquills ; but while they had not this effea, they often counteraaed the intention in view, and arc therefore omitted. It is ufed chiefly in dofes of a fpoonful 01 two, for promoting expeaoration, which it does very powerfully. SYRUPUS TOLUIFER.E BALSAMI; vulgo, Syrupus Balsamicus. Edin. Syrup of Balfam ofTolu, formerly Balfamic Syrup. Take of Common Syrup, two pounds ; Tinaure ot balfam of Tolu,.one ounce. With the fyrup recently prepared, and when it has almoft grown cold, after it has been removed from the fire, gradually mix the tinaure with conftant agitation. Syrupus Tolutanus, Lond. Syrup ofTolu, Take of The balfam of Tolu, eight ounces ; Diftilled water, three pints. Boil for two hours. Mix the double refined fugar with the liquor, ftrained after it is cold, that it may be made a fyrup. The intention of the contrivers of the two foregoing proceffes feems to have been fomewhat different. In the latter, which is certainly the moft elegant, the benzoic acid of the balfam alone is contained ; the other fyrup contains the whole fubftance of the balfam in larger quantity. They are both moderately impregnat- ed with the agreeable flavor of the balfam, SYRUPUS VIOL^E ODORAT.E. Edin. Syrup of Violets. Take of Freffi violets, one pound ; Boiling water, four pounds ; Double refined fugar, feven pounds and a half. Macerate the violets in the water for twenty four hours in a glafs or a glazed earthen veffel, clofe covered ; then ftraia without expreffion, and to the ftrained liquor add the fugar, powdered, and make into a fyrup. Syrupus Viola. Lond. Dub. Syrup of Violets. Take of The frefli petals of the violet, two pounds ; Boiling diftilled water, five pints, (fix pounds, Dub.) 63-4 546 Preparations and Compositions. [Part III. Macerate for twentyfour hours ; afterwards ftrain the liquor, without expreffion, through thin linen. Add double refined fugar, that it may be made a fyrup. This fyrup has a very agreeable flavor ; and in the quantity of a fpoonful or two proves to children gently laxative. It is apt to lofe, in keeping, the elegant blue color, for which it is chiefly valued ; and hence fome have been induced to counterfeit it with materials whofe color is more permanent, and which are more eafily obtained. This abufe may be readily difcovered, by add- ing to a little of the fufpeaed fyrup any acid or alkaline liquor. If the fyrup be genuine, the acid will change it red, and the alka- li green ; but it counterfeit, thefe changes will not happen. From this mutability of the color of the violet, it forms an excellent teft of the prefence of acids and alkalies ; and, it is alfo obvious, that a prefcriber would be deceived if he ffiould expea to give any blue tinge to acidulated or alkalized juleps or mixtures, by the addition of the blue fyrup. CHAP. XXVII. MEDICATED H.ONEYS. MEL DESPUMATUM. Edin. Dub. Clarified Honey, Mellis Despumatio. Lond. The Clarification of Honey. Melt the honey in a water bath, and remove the fcum as it rifes. In this fimple procefs, the honey is rendered fo liquid by the heat of the boiling water, that the wax and other lighter impuri- ties which it commonly contains, rife to the furface in the form of a fcum, which is eafily removed. At the fame time, fand or any heavier mixture of that kind finks to the bottom. Mel Acetatum. Lond. Acetated Honey. Oxymel Simplex. Dub. Simple Oxymel. Take of Clarified honey, two pounds ; Diftilled vinegar, one pound by weight, Chap. XXVII.] Of Medicated Honeys. 547 Boil them in a glafs veffel with a gentle fire to the confiftency of a fyrup, (Lond.) Having mixed them, bring them thrice to boil in a glafs veffel, and remove the fcum each time, (Dub.) This was once ia great repute as a cooling and attenuating me- dicine ; it is fcarcely ufed in modern praaice, except in colds at- tended with coughs, and in fore throats, for which, when diluted with fome aromatic or aftringent infufion, as fage tea, rofe flower tea, &c. it makes ufeful gargles. OXYMEL COLCHICL Lend. Oxymel of Meadow Saffron. Take of The frefh root of meadow faffron, cut into thin flices, one ounce ; Diftilled vinegar, one pint ; Clarified honey, two pounds. Macerate the root of meadow faffron, with the vinegar, in a glafs veffel, with a gentle heat, for forty eight hours. Strain the li- quor, preffed out ftrongly from the root, and add the honey. Laftly, boil the mixture, frequently ftirring it with a wooden fpoon, to the thicknefs of a fyrup. This is an aaive preparation, but its ufe may be entirely fuperfeded by the fyrup of the fame root. MEL ROS.E. Lond. Dub. Honey of Rofes, Take ot Dried red rofe buds (with the heels cut off, Dub.) four ounces; Boiling diftilled water, three pints ; Clarified honey (Honey, Dub.) five pounds. Macerate the rofe leaves in the water for fix hours ; then mix the honey with the ftrained liquor, and boil the mixture to the thicknefs of a fyrup (removing the fcum, Dub.) This preparation is not unfrequently ufed as a mild cooling detergent, particularly in gargarifms for ulcerations and inflam- mation of the mouth and tonfils. Therofebuds here ufed ffiould be haftily dried, that they may the better preferve their aftrin- gency. The Dublin College, in making this and other fimilar prepa- rations, ufe unclarified honey, with the idea, probably, that it may be equally well clarified in the courfe of the preparation itfelf. This is no doubt true, but as we do not know what effea the clar- ification may have on the aaive fubftances added to the honey, we think that the ufe of clarified honey, as directed by the London College, is preferable. 548 Preparations and Compositions. [Part III. MEL SCILLvE. Lond. Mel Scilliticum. Dub. Honey of Squills. Take of Clarified honey (Honey, Dub.) three pounds; Tinaure of fquills, two pints. Boil them in a glafs veffel to the thicknefs of a fyrup (removing the fcum, Dub.) The honey will here be impregnated with all the aaive parts of the fquills which the tinaure before contained, and may be em- ployed as an ufeful expeaorant or diuretic. OXYMEL SCILLA. Lond. Oxymel of Squills,. Take of Clarified honey, three pounds; Vinegar of fquills, two pints. Boil them in a glafs veffel, with a flow fire, to the thicknefs of a fyrup. Oxymel of fquills is a ufeful aperient, detergent, and expec- torant, and of great fervice in humoral afthmas, coughs and other diforders where thick phlegm abounds. It is given in dofes of two or three drachms, along with fome aromatic water, as that ot cinnamon, to prevent the great naufea which it would otherwife be apt to excite. In large dofes, it proves emetic. OXYMEL ^RUGINIS. Lond. Oxymel of Verdegris. Take of Prepared verdegris, one;Ounce ; Vinegar, feven ounces. Clarified honey, fourteen ounces, Diffolve the verdegris in the vinegar, and ftrain it through linen ; then add the honey, and boil the whole to a proper thicknefs. It is ufed only externally for cleanfing foul ulcers, and keep- ing down fungous fleffi. It is alfo often ferviceable in venereal ul- cerations of the mouth and tonfils: But there is fome danger from its application to places from the fituation of which it is apt to be fwallowed ; for even a fmall quantity of verdegris paffing into the ftomach may beproduaiveof diftrefling, if not deleterious effeas. Chap. XXVIII.] Of Emulsions and Mixtures. 549 CHAP. XXVIII. EMULSIONS and MIXTURES. In this chapter we comprehend thofe mixtures in which oils and other fubftances infoluble in water, are mixed with and fuf- pended in watery fluids, by means of mechanical divifion and vif- cid fubftances, fuch as mucilages and fyrups. EMULSIO AMYGDALAE COMMUNIS, Edin. Almond Emulfion. Take of Sweet Almonds, one ounce; Water, two pounds and a half. Beat the blanched almonds in a ftone mortar, gradually pouring on them the water; then ftrain off the liquor. Lac Amygdala. Lond. J,ac Amygdalarum. Dub, Almond Milk. Take of J Sweet almonds, an ounce and a half. Double refined fugar, halt an ounce. Diftilled water, two pints. Beat the almonds with the fugar ; then rubbing them together, add by degrees the water, and ftrain the liquor. EMULSIO ARABICA. Edin. Arabic Emulfion. This is made in the fame manner as the almond emulfion; only adding, while beating the almonds, Mucilage of gum Arabic, two ounces. 550 Preparations and Compositions. [Part III. Emulsio Arabica. Dub. Arabic Emulfion. Take of Gum Arabic in powder, two drachms ; Almonds blanched, half an ounce ; Double refined fugar, three drachms ; Decoaion of barley, one pound. Diffolve the gum in the warm decoaion, and when it is almoft cold, pour it upon the almonds, previoufly well beaten with the fugar, and at the fame time triturate them together, fo as to form a kind of milk, and then filter. All thefe may be confidered as poffeffing nearly the fame qual- ities. They are merely mechanical fufpenfions of oil of almonds in watery fluids, by means either of the mucilage with which it is naturally, combined in the almonds by itfelf, or affifted by the addition of gum Arabic and fugar. Therefore, on ftanding for fome days, the oily matter feparates and rifes to the top, not in a pure form, but like thick cream. By heat the fame decompofi- tion is immediately effeaed. Great care fhould be taken that the almonds have not become rancid by keeping ; which will not only render the emulfion ex- tremely unpleafant, a circumftance of great confequence in a med- icine that requires to be taken in large quantities, but likewife give it injurious qualities. The almonds are blanched by infufing them in boiling water, and peeling them. The fuccefs of the preparation depends upon the attention paid to beating the almonds to a fmooth pulp, and to triturate them with each portion of the watery fluid, fo as to form an uniform mixture before another portion be added. Thefe liquors are principally ufed for diluting and obtunding acrimonious humors ; particularly in heat of urine and ftrangu- ries, arifing either from a natural fharpnefs of the juices, or from the operation of cantharides, and other irritating medicines ; in thefe cafes they are to be drunk frequently, to the quantity of half a pint or more at a time. EMULSIO CAMPHORATA. Edin. Camphorated Emulfion. Take of Camphor, one fcruple; Sweet almonds, blanched, two drachms ; Double refined fugar, one drachm ; Water, fix ounces. This is to be made in the fame manner as the common emulfion^ Chap. XXVIII.] Of Emulsions and Mixtures. 551 MlSTURA CAMPHORATA. Lond. Camphorated Mixture. Take of Camphor, one drachm; Reaified fpirit ot wine, a little ; Double refined fugar, half an ounce ; Boiling diftilled water, one pint. Rub the camphor firft with the fpirit of wine, then with the fu- gar ; laftly, add the water by degrees, and ftrain the mixture. While camphor is often exhibited in a folid ftate, it is fre- quently alfo advantageous to employ it as diffufed in watery flu- ids ; and with this intention the latter formula is perhaps one of the moft fimple, the union being effeaed merely by the aid of a fmall quantity of fpirit of wine and a little fugar. The form of emulfion in which the union is effeaed, by triturating the cam- phor with a few almonds, is however much fuperior ; for the unc- tuous quality of the almonds ferves in a confiderable degree to cover the pungency of the camphor, without diminifhing its ac- tivity. Camphor, under both forms, is very ufeful in fevers, ta- ken to the extent of a table fpoonful every three or four hours. It is a curious quantity of fpirit which the London College has ordered ; more efpecially fince in a former edition the quantity of fpirit was fpecified, viz. ten drops. LAC AMMONIAC! Lond. Dub. Emulfion of Gum Ammoniac. Take of Gum ammoniac, two drachms ; Diftilled water, half a pint (eight ounces, Dub.) Rub the gum refin with the water, gradually poured on, until it becomes an emulfion. Lac Asa Foetida. Lond. Emulfion of Afafcetida. In the fame manner may be made an emulfion of afa fcetida, and of the reft of the gum refins. The lac ammoniaci is employed for attenuating tough phlegm, and promoting expeaoration, in humoral afthmas, coughs, and obftruaions of the vifcera. It may be given to the quantity of two fpoonfuls twice a day. The lac afa fcetida is employed in fpafmodical, hyfterical, and other nervous affeaions. And it is alfo not unfrequently ufed under the form of injeaion. It anfwers the fame purpofes as afa fcetida'in fubftance. I 552 Preparations and Compositions. [Part III. MISTURA MOSCHATA. Lond. Mufk Mixture. Take of Mufk, two fcruples ; Gum Arabic, powdered, Double refined fugar, of each one drachm ; Rofe water, fix ounces by meafure. Rub the mufk firft with the fugar, then with the gum, and add the rofe water by degrees. This had formerly the name of Julepum e mofcho, and was in- tended as an improvement upon the Hyfieric julep with mufk of Bates. The julep appears turbid at firft : On ftanding a little time, it depofites a brown powder, and becomes clear, but at the fame time lofes great part of its virtue. This inconvenience may be prevented by thoroughly grinding the mufk with gum Arabic before the addition of the water : By means of the gum, the whole fubftance of the mufk is kept fufpended in the water. POTIO CARBONATIS CALCIS; olim.PoTio Cretacea. Edin. Chalk Potion. Take of , Prepared carbonate of lime, one ounce ; Double refined fugar, half an ounce ; Mucilage of gum Arabic, two ounces. Triturate together, and then gradually add of Water, two pounds and a half ; Spirit of cinnamon, two ounces. Mix them. Mistura Cretacea. Lond. Dub. Chalk Mixture. Take of Prepared chalk, one ounce ; (half an ounce, Dub.) Double refined fugar, fix drachms ; (three drachms, Dub.) Gum Arabic, powdered, one ounce ; Diftilled water, two pints ; (fifteen ounces, Dub.) Mix them. This is a verv elegant form of exhibiting chalk, and is an ufe- ful remedy in difeafes arifing from, or accompanied with acidity in the pri.' chona, but not to fuch a degree that it can be given in fufficient dofes to aa as cinchona, without exhibiting more ardent fpirit than what is proper to be given as a medicine. Indeed we are afraid that this and other bitter and tonic tinaures, as they are called, are with fome only an apology for dram drinking, and that the moft apparent effeas they produce are thofe of a flight degree of intoxication. TINCTURA CINCHONA, sive CORTICIS PERUVIA- NI, COMPOSITA. Lond. Dub. Compound TinBure of Peruvian Bark. Take of Take of Opium, cut into fmall pieces, one pound ; Proof fpirit of wine, twelve pints. Digeft the opium with a gentle heat, ftirring now and then till it be diffolved, and filter through paper. Diftil the tinaure, fo prepared, to a proper thicknefs (tor making into pills, Dub.) (Purified opium muft be kept in two forms ; one foft, proper tor forming into pills; the other hard, which may be reduced into powder, Lond.) The chapter on extraas and refins in the London Pharmaco- poeia is concluded with the two following general direaions : 1. All the extrafcis, during the time of infpiffation, muft be greatly agitated. 2. On all the fofter watery extraas, a fmall quantity of fpirit of wine muft be fprinkled. All thefe extraas are fuppofed to contain the virtues of the fub- ftances from which they are prepared, in a very pure and concen- trated form : But this fuppofition is, we believe, in feveral in- ftances erroneous; and the direaions for preparing them are fre- quently injudicious and uneconomical. As the changes which opium and aloes undergo by folution, and fubfequent evaporation, have never been afcertained by careful and fa.isfaaory experiments, we prefer well felefcled pieces of Chap. XXXIV.] Of Extracts and Resins, 597 thefe fubftances to the preparations in which they are fuppofed tp be purified. Cinchona bark is a medicine ol very great importance ; but unfortunately the proportion of woody fibres, or inert matter, which enter into its compofition is fo great, that weak ftomachs cannot bear it, when given in any quantity fufficient to produce any very powerful effeas. Qn this account, the preparation ot an extraa, which may contain its aaive principles in a concen- trated form, becomes alfo an objea of importance. On this fubjea there is ftill much room for experiment. The London and Dub- lin Colleges, in their direaions, certainly err in two important particulars ; in the firft place, in defiring the decoaion to be con- tinued until the greateft part of the menftruum is evaporated ; and, in the fecond place, in feparating by filtration the powder which feparates from the decoaion after it has cooled. 1 he firft error probably originated in the idea, that by continuing the boil- ing for a great length of time more of the bark would be diffolved ; but we now know that water is incapable ot diffolving more than a certain quantity of the aaive principles of bark ; and that after the water has become faturated, by continuing the decoaion we diminifh the quantity of the menftruum, and theietore alfo dimin- ifh the quantity of bark diffolved. It is not fo eafy to account for the fecond error; for, according to the old idea, that the pow- der which feparated on cooling from a faturated decoaion of cin- chona, was a refinous fubftance, it furely ought not to have been rejeaed from what were fuppofed to be refinous extraas. This precipitate is now known to be caufed by the much greater folu- bility of tannin in boiling than in cold water, fo that the precipi- tate is not different from what remains in folution. According- ly we have found by experiment, that cinchona gave at leaft que half more extract when the decoaion were conduaed according to the direaions of the Edinburgh College. The real advantage of fo expenfive an agent as alcohol, in pre- paring any of thefe extraas, has not been demonftrated ; and, if we are not mifinformed, it is feldom employed by the apotheca- ries in preparing, even what are called the Refinous Extraas. The fame obfervations apply to the preparation ot other aftrin- gent extraas, fuch as thofe of logwood and oak bark. RESINA FLAVA. Lond. Dub. Yellow Refin. This remains in the retort after the diftillation of oil of turpentine. Turpentines are combinations of volatile oils and refins, which are eafily feparated by diftillation. The procefs, however, 598 Preparations and Compositions. [Part III. cannot be carried fo far as to feparate the whole of the oil, with- out charring and burning the refin. In this ftate it has a brown color and a certain degree of tranfparency, and is well known un- der the name of Fiddler's Rofin. But, if water be added to the refiduum of the diftillation, and be thoroughly mixed with it by agitation, it becomes opaque, and is called Yellow Rofin. Yellow rofin is a ufeful ingredient in the compofition of plaf- ters and hard ointments. AMMONIACI PURIFICATIO. . Lond. The Purification of Gum Ammoniacum. If gum ammoniac'do not feem to be pure, boil it in water till it become foft ; then fqueeze it through a canvafs bag, by means of a prefs. Let it remain at reft till the refinous part fubfide ; then evaporate the water ; and towards the end ol the evapora- tion, mix the refinous part with the gummy. In the fame manner are purified afafatida and fimilar gum refins. You may alfo purify any gum which melts eafily, fuch as Galba- num, by putting it in an ox bladder, and holding it in boiling water till it become fo fott that it can be feparated from its im- purities by preffing through a coarfe linen cloth. As one, and perhaps the moft aaive conftituent of gummy re- fins as they are called, is of a volatile nature, it is evident that it muft be in a great meafure diffipated in the procefs juft defcribed and that we cannot expefct the fame virtues in thefe fubftances af- ter they are purified, which they poffefs in their crude ftate.This procefs is therefore contrary to the principles of good pharmacy ; and fuch fpecimens ot thefe gummy refins as ftand in need of it to give them an apparent degree of purity, fhould not be admit- ted into the fhop ot the apothecary. Befides, many of the impu- rities which they ufualiy contain, are eafily feparated in compound- ing the preparations or extemporaneous prefcriptions into which they enter. STYRAX PURIFICATA. Lond. Dub. Purified Storax. STYRACIS PURIFICATIO. The Purification of Storax. Diffolve the ftorax in refctified fpirit of wine, and ftrain the folu- tion ; afterwards reduce it to a proper thicknefs with a gentle heat. Storax is a balfam or combination of refin and benzoic acid, both of which are foluble in alcohol, and neither of them volatile in the heat neceffary for evaporating alcohol. The procels far purifying it is therefore not liable to any chemical objefctions. Chap. XXXV.] Of Powders. 599 CHAP. XXXV. Of POWDERS. This form is proper for fuch materials only as are capable of being fufficiently dried to become pulverifable, without the iofs of their virtue. There are many fubftances, however, of this kind which cannot be conveniently taken in powder ; bitter, acrid, fe- tid drugs are too difagreeable; emollient and mucilaginous herbs and r®ots are too bulky ; pure gums cohere, and become tenacious in the mouth ; fixt alkaline falts deliquefce when expofed to the air; and volatile alkalies exhale. Many of the aromatics, too, fuffer a great lofs of their odorous principle when kept in powder ; as in that form they expofe a much larger furface to the air. The dofe of powders, in extemporaneous prefcription, is gener- ally about half a drachm ; it rarely exceeds a whole drachm ; and is not often lefs than a fcruple. Subflances which produce power- ful effeas in fmaller dofes-are not trufted to this form, unlefs their bulk be increafed by additions of lefs efficacy ; thofe which re- quire to be given in larger ones are better fitted for other forms. The ufual vehicle for taking the lighter powders, is any agree- able.thin liquid. The ponderous powders, particularly thofe pre- pared from metallic fubftances, require a more confiftent vehicle, as fyrups ; for from thin ones they foon fubfide. Refinous fub- ftances likewife are moft commodioufly taken in thick liquors ; in thin ones, they are apt to run into lumps, which are not eafily again foluble. PULVIS ALOES cum CANELLA. Lond. Powder of Aloes-with Canella. Take of Socotorine aloes, one pound ; White canella, three ounces. Powder them fepatately, and then mix them. This compofition has long been known in the fhops under the title of Hiera Picra. It furnifhes us with an ufeful alcetic pur- gative, the canella operating as a good corrigent for the aloes.— But it is more frequently employed as the bafis of eJeauaries or pills. 600 Preparations and Compositions. [Part lit. PULVIS ALOETICUS cum GUAIACO. Lond. Aloetic Powder with Guaiacum. Take of Socotorine aloes, one ounce and an half ; Gum guaiacum, one ounce; Aromatic powder, half an ounce. Rub the aloes and gum guaiacum feparately to powder ; then mix them with the aromatic powder. This alfo furnifhes us with a ufeful purgative ; but when ta. ken only in fmall dofes, its chief effeas is that of promoting per- fpiration. PULVIS ALOETiCUS cum FERRO. Lond. Aloetic Powder with Iron. Take of Socotorine aloes, an ounce and an half; Myrrh, two ounces ; Dry extraa of gentian, Vitriolated iron, of each one ounce. Reduce them feparately to powder, and mik them. In this powder we have an aloefic and chalybeate conjoined. It is an ufeful medicine, and is particularly employed with ad- vantage in cafes of obftruaed menftruation. PULVIS AROMATICUS. Lond. Dub. Aromatic Powder. Take of Cinnamon, two ounces; Smaller cardamom feeds, hufked, Ginger, Long pepper, of each one ounce. Rub them together to a powder, (which is to be kept in a well corked phial, Dub.) Edin. Take of Cinnamon, Smaller cardamom feeds, Ginger, each equal parts. Reduce them to a very fine powder, which is to be kept in a glafs veffel well clofed. Both thefe compofitions are agreeable, hot fpicy, medicines ; and as fuch may be ufefully taken in cold phlegmatic habits and Chap. XXXV.] Of Powders. 601 decayed conftitutions, for warming the ftomach, promoting di- geftion, and ftrengthening the tone of the vifcera. The dofe is from ten grains to a fcruple and upwards. The firft is confidera- bly the warmeft, from the quantity of long pepper which it con- tains. PULVIS ASARI COMPOSITUS. Lond. Dub Compound Powder of Afarabacca, Take of Afarabacca, Sweet marjoram, Syrian herb maftich, Lavender, of each, dried, one ounce. Reduce them together to powder, which is to be kept in a clofed phial. PULVIS ASARI EUROPAI COMPOSITUS. Edin. Compound Powder of Afarabacca. Take of The leaves of afarabacca, three parts ; —---------- marjoram. Flowers of lavender, of each one part. Rub them together to powder. They are both agreeable and efficacious errhines, and fuperior to moft of thofe ufually fold under the name of herb fnuff They are ofteri employed With great advantage in cafes ot obftinate headach, and of ophthalmias refifting other modes ot cure. Taken under the form of fnuff to the extent of five or fix grains at bed- time, they will operate the fucceeding day as a powerful errhine, inducing frequent fneezing, and likewife a copious difcharge from the nofe. It is, however, neceffary, during their operation, to avoid expofure to cold. PULVIS CARBONATIS CALCIS COMPOSITUS ; olim, Pulvis Cretaceus. Edin. Compound Powder of Carbonate of Lime, formerly Chalk Powder. Take of Prepared carbonate of lime, four ounces ; Nutmeg, half a drachm ; Cinnamon, one drachm and a half. Reduce them together to powder. 260 Preparations and Compositions. [Part III. Pulvis Cret.e Compositus. Lond. Compound Powder of Chalk. Take of Pr-p.irel ch-i'k, half a pound; Cinn.'moii, four ounces ; Torment il, Gum Archie, of eacli three ounces ; Long pepper, halt an ounce. P-^rt'dtr them ieparately, and mix them. The addition of the aromatics in the above formula, coincides will) ihe general intention of the remedy, which is indicated for weaknefs and acidity in the ftomach, and in loofenefs from acidity. PULVIS CRETA COMPOSITUS cum OPIO. Lond- Compound Powder of Chalk with Opium. Take of Compound powder of chalk, eight ounces ; Hard purified opium, powdered one drachm and an half. Mix them. From the addition of the opium this remedy becomes ftill more powerful than the above in reftraining diarrhoea. PULVIS CHELARUM CANCRI COMPOSITUS. Lond. Compound Powder of Crabs Claws. Take of Crabs claws, prepared, one pound ; !Chalk, Red coral, each prepared, three ounces. Mix them. The invention of this formula muft be afcribed folely to theun- philofophical idea, that the fum of the powers of medicine was increafed by mixing them together ; for the prefent powder is a mixture of three varieties of carbonate of lime, which, notwith- ftanding the immenfe differences of their prices, do not differ in their effeas. PULVIS CERUSSA COMPOSITUS. Lond. Compound Powder of Cerufe* Take of Cerufe, five ounces ; Sarcocoll, an ounce and a half. Chap. XXXV.] , Of Powders. . £03 Tragacanth, half an ounce. Powder them together, This is employed tor external purpofes, as in collyria, lotions, and injeaions for repelling acrimonious humors, and in inflam- mations ; but for all thefe purpofes it is very inferior to folutions of acetite of lead. PULVIS CONTRAYERVA COMPOSITUS. Lond. Compound Powder of Contrayerva. Take of Contrayerva, powdered, five ounces ; Compound powder of crabs claws, one pound and a half. Mix them. This medicine has a very good claim to the title of an alexi- pharmic and fudorific. The contrayerva by itfelf proves very ferviceable in low fevers, where the vis vitsc is weak, and a dia- phorefis to be promoted. It is poffible, that the crabs claws are of no farther fervice than as they divide this aaive ingredient, and make it fit more eafily on the ftomach. PULVIS IPECACUANHA ET OPII. Edin. Pulvis Ipecacuanha. Compositus ; olim Pulvis Do- ver i. Lond, Dub. Powder of Ipecacuanha and Opium, or Compound Powder of Ipe- cacuan, formerly Dover's Powder.' Take of Ipecacuanha, in powder, Opium, (purified, Dub. hard purified, Lond.) of each one part; Sulphate of potafs, eight parts. Triturate them together into a fine powder. The fulphate of potafs, from thegrittinefs of its cryftals, is perhaps better fitted for tearing and dividing the tenacious opium than any other fait; this feems to be its only ufe in the prepara- tion. The operator ought to be careful that the opium and ipe- cacuanha be equally diffufed through the whole mafs of powder, otherwife different portions of the powder muft have differences in degree of ftrength. This powder is one of the moft certain fudorifics, and, as fuch, was recommended by Dr. Dover as an effeaual remedy in rheu- matifm. Modern praaice confirms its reputation, not only in rheumatifm, but alfo in dropfy and feveral other difeafes, where it is often difficult by other means to produce a copious fweat. The dofe is from five to twenty grains, according as the patient's ftom- ach and ftrength can bear it. It is proper to avoid much drink- . ing immediately after taking it, otherwife it is very apt to be re- jeaed by vomiting before any other effeas are produced, 604 Preparations and Compositions. [Part III. PULVIS JALAPA COMPOSITUS. Edin. Compound Powder of Jalap. Take of Jalap root, one part ; Supertartrite of potafs, two parts. Grind them together to a very fine powder. The ufe of the cryftals in this preparation, is to break down and divide the Jalap ; and therefore they are direaed to be tritu- rated together, and not feparately. PULVIS MYRRHA COMPOSITUS. Lond. Compound Powder of Myrrh. Take of Myrrh, Dried favin, ------rue, Ruffian caftor, of each one ounce. Rub them together into a powder. This is a reformation of the Trochifci e Myrrha, a.compofi- tion contrived by Rhazes againft uterine obftruaions. From a fcruple to a drachm or more, two or three times a day, may be taken in any convenient vehicle, or made into bolufes. PULVIS OPIATUS. Lond. Opiate Powder. Take of Hard purified opium, powdered, one drachm ; Burntnd prepared hartffiorn, nine drachms. Mix them. Edin. Take of • Opium, one part; Prepared carbonate of lime, nine parts. Rub them together to a fine powder. In thefe powders the opium is the only aaive ingredient ; and it is immaterial whether the phofphate or carbonate of lime be ufed to promote its mechanical divifion. PULVIS SCAMMONH COMPOSITUS. \Lond. Compound Powder of Scammonv. Take of J J Scammony, Hard extraa of Jalap, of each two ounces; Chap. XXXV.] Of Powders. 605 Ginger, half an ounce. Powder them feparately, and mix them* Edin, Take of Scammonyj Supertartrite of potafs, equal parts. Rub them together to a very fine powder. Dub. Take of Scammony, Vitriolated vegetable alkali, each two ounces ; Ginger, half an ounce. Powder them feparately, and then mix them. In the firft of thefe compofitions, the fcammony is combined' with another purgative more aaive than itfelf, and in the others, with one much lefs fo ; which difference muft be attended to in prefcription. The ginger is an ufeful addition, and will render it lefs apt to gripe. PULVIS SCAMMONII COMPOSITUS cum ALOE. Lond. Compound Powder of Scammony with Aloes. Take of Scammony, fix drachms ; Hard extraa of jalap^ Socotorine aloes, of each an ounce and an half; Ginger, half an ounce. Powder them feparately, and mix them. In this formula, the combination of fcammony, jalap, and aloes, furnifhes a very aaive purgative, which, with fome intentions at leaft, may be preferable to either of the preceding. From five to ten grains of it operate as a purgative, even in cafes of obftinate coftivenefs. PULVIS SCAMMONII cum CALOMELANE. Lond. Powder of Scammony with Calomel, Take of Scammony, half an ounce ; Calomel, Double refined fugar, of each two drachms. Powder them feparately, and then mix them. In this formula, we have the fcammony in a more fimple ftate, united with fuch a proportion of calomel, as muft very confidera- bly aid its purgative power ; and accordingly it may be employ- er * 606 Preparations and Compositions. [Part III. ed with advantage, both in cafes of obftinate coftivenefs, and in dropfical affeaions, where a confiderable difcharge is required from the fyftem. PULVIS SENNA COMPOSITUS. Lond. Compound Powder of Senna. Take of Senna, Cryftals of tartar, of each two ounces ; Scammony, half an ounce ; Ginger, two drachms. Rub the fcammony by itfelf, rub the reft together into a powder, and then mix them all. This powder is given as a cathartic, in the dofe of two fcru- ples, or a drachm. The fpice is added, not only to divide, but to warm the medicine, and make it fit eafier on the ftomach. The fcammony is ufed as a ftimulus to the fenna ; the quantity of the latter neceffary for a dofe, when not affifted by fome more power- ful material, being too bulky to be conveniently taken in this form. PULVIS SULPHATIS ALUMINA COMPOSITUS ; olim, Pulvis Styp^Itcus. Edin. Compound Powder of Sulphate of Alumina, formerly Styptic Pow- der. Take of Sulphate of alumina, four parts ; Kino, one part. Rub them together to a fine powder. This powder is compofed of two very powerful aftringents, but which we believe are.not combined with propriety. At leaft, it is certain that a folution of alum is decompofed by a folution of kino. PULVIS TRAGACANTHA COMPOSITUS. Lond. Compound Powder of Tragacanth. Take of Tragacanth, powdered, Gam Arabic, <■ Starch, ot each an ounce and an half ; Double refined fugar, three ounces. Rub them together into a powder. This compofition is a mild emollient; and hence becomes fer- viceable in heaic cafes, tickling coughs, ftrangury, fome kinds of alvine fluxes, and other diforders proceeding from a thin acri- Chap. XXXVI.] Of Conserves. 607 monious ftate of the humors, or an abrafion of the mucus of the inteitines ; they foften, and give a greater degree of confiftency to the former, and defend the latter from being irritated or exco- riated by them. All the ingredients coincide in thefe general in- tentions. The dofe is from half a drachm to two or three drachms, which may be frequently repeated. CHAP. XXXVI. CONSERVES. Conserves are compofitions of recent vegetable matters and fugar, beaten together into an uniform mafs. This management is introduced for preferving certain fimples, undried, in an agreeable form, with as little alteration as poffible in their native virtues ; and to fome fubjeas it is very advantal geoufly applied. Vegetables, whofe virtues are loft or deftroyed in drying, may in this form be kept uninjured for a length of time ; for, by carefully fecuring the mouth of the containing vef- fel, the alteration, as well as diflipation of their aaive principles, is generally prevented ; and the fugar prefervcs them from the corruption which juicy vegetables would otherwife undergo. The fugar fhould be pounded by itfelf, and paffed through a fieve, before it be mixed with the vegetable mafs, for without this it cannot be properly incorporated. Rofe buds, and fome other vegetables, are prepared for mixing with fugar by a fmall wooden mill, contrived for that purpofe. There are, however, vegetables whofe virtues are impaired by this treatment. Mucilaginous fubftances, by long lying with fu- gar, become lefs glutinous ; and aftringents fenfibly become fofter upon the palate. Many of the fragrant flowers are of fo tender and delica;e a texture, as almoft entirely to lofe their peculiar qualities on being beaten or bruifed. In general, it is obvious, that in this form, on account of the large admixture of fugar, only fubftances of confiderable aaivity can oe taken with advantage as medicines. And, indeed, conferves arf* at prefent confidered chiefly as auxiliaries to medicines of g-rater efficacj, or as intermediums for joining them together. Tney are very convenient for reducing into bolufes or pills the more ponderous powders, as fubmuriate of mercury, the oxides of iron. *nd other mineral preparations ; which, with liquid or lefs confiftent matters, as fyrups, will not cohere* 608 Preparations and Compositions. [Part. Ill, The fhops were formerly encumbered with many conferves al- together i ifignificant ; the few now retained have in general eith- er an agreeable flavor to recommend them, or are capable of an- fwering fome ufeful purpofes as medicines. Their conimon dofe is the bulk of -a nutmeg, or as much as can be taken up at once or twice upon the point of a knife. There is, in general, no great danger of exceeding in this particular, CONSERVE CONSERVES Edin. Corticis exterioris recentifruc- Of the outer rind of oranges, tus Citri Aurantii, radula rafped off by a grater. abrafi. FruBus Rofae Caninae, maturi Of the pulp of ripe hips, freed* a f minibus eorumque pube from the feeds and hairs ad- feliate purgata. hering to them. Petalorum Rofae Rubrae nondum Of red rofe buds. explicitorum. Beat each of thefe to a pulp, gradually adding, during the beating three times their weight of double refined fugar. CONSERVE CONSERVES Lond. Ablinthii Maritimi. Of fea wormwood. Corticis exterioris Aurantii Hif- Of the outer rind of the Seville pGl"nfis. orange. Lujula. 0\ wood forrel. Rofa Rubra. Of the red rof:. Pluck the leaves from the ftalks, the unblown petals from the cups, taking off the heels. Take off the outer rind of the oranges by a grater. When pre- pared in this way, beat them with a wooden peftle in a marble mortar, fii ft by themfelves, afterwards with three times their weight of double refined fugar until they be mixed. CONSERVA CYNOSBATI, Lond. Conferve of Hips. Take of Pulp of ripe hips, one pound ; Doable refined f,gar, powdered twenty ounces, Mix them into a conferve. % Chap. XXXVI.] Of Conserves. 609 CONSERVA ACETOSELLA. Dub. Conferve of Wood Sorrell. Beat the leaves of wood forrel. gradually adding twice their weight of double refined fugar. CONSERVA CORTICIS AURANTII. Dub. Conferve of Orange Peel. To the outer peel of Seville oranges taken off with a grater, gra- dually add three times its weight of double refined fugar, while beating them together. CONSERVA ROSA. Dub. Conferve of Rofes. Beat the petals of red rofe buds freed from the calices and heels, gradually adding three times their weight of double refined fu- gar. It is fcarcely neceffary to make any particular remarks on thefe conferves. Their tafte and virtues are compounded of thofe of fugar, and the fubftance combined with it. The wood forrel and hips are acidulous and refrigerant ; the orange rind and worm. wood bitter and ftomachic, and the red rofe buds aftringent. CONSERVA ARI. Lond. Conferve of Arum. Take of Freffi root of arum, bruifed, half a pound ; Double refined fugar, a pound and a half. Beat them together in a mortar. This is one of the beft forms for exhibiting this fimple, as its virtues are deftroyed by drying, and are not extradited by any men- ftruum. It may be given to adults in dofes of a drachm. CONSERVA PRUNI SYLVESTRIS. Lond. Conferve of Sloes. *. Put the floes in water upon the fire that they may foften taking care that they be not broken ; then the floes being taken out o the water, prefs out the pulp, and mix it with three times its weight of double refined fugar into a conferve. This preparation is a gentle aftringent, and may be given a* fuch in the dofe of two or three drachms. 610 Preparations and Compositions. [Part III. CONSERVA SCILLA. Lond. Conferve of Squills. Take of \ Freffi fquills, one ounce ; Double refined fugar, five ounces. Beat them together in a mortar into a conferve. This conferve is direaed to be prepared in a fmall quantity, to guard againft its varying in ftrength. It may be given to adults, in dofes of from half a drachm to two fcruples, efpecially when frefh. The conferve of fquills is a more uncertain and lefs agreeable mode of exhibiting this article, than the powder of the dried root made into pills, or a bolus with any other conferve. The London College conclude their chapter on conferves, with defiring all the conferves, efpecially thofe of arum and fquills, to be kept in clofe veffels. CHAP. XXXVII. ELECTUARIES and CONFECTIONS. Electuaries are compofed chiefly of powders mixed up with fyrups, &c. into fuch a confiftence, that the powders may • not feparate in keeping, that a dofe may be eafily taken up on the point of a knife, and not prove too ftiff to fwallow. Eleauaries receive chiefly the milder alterative medicines, and fuch as are not ungrateful to the palate. The more powerful drugs, as cathartics, emetics, opiates, and fhe like (except in offi- cinal eleauaries to be difpenfed by weight) are feldom trufted in this form, on account of the uncertainty of the dofe; difguftful * ones, aarids, bitters, fetids, cannot be conveniently taken into it; gpor is the form of an eleauary well fitted for the more ponderous fubftances, as mercurials, thefe being apt to fubfide on keeping, unlefs the compofition be made very ftiff. The lighter powders require thrice their weight of honey, or fyrup, boiled to the thicknefs of honey, to make them into the confiftence of an eleauary ; of fyrups of the common confiftence, twice the weight of the powder re fufficient. Where the common fyrups are employed, it is neceffary to add likewife a little conferve, to prevent the compound from drying Chap. XXXVII.] Of Electuaries and Confections. 611 too foon. Eleauaries of Peruvian bark, for inftance made up with fyrup alone, will often in a day or two grow too dry for taking. Some powders, efpecially thofe of the lefs grateful kind, are more conveniently made up with mucilage than with fyrup, honey, or conferve. The three latter flick about the mouth and fauces, and thus occafion the tafte of the medicine to remain for a confid- erable time ; whilft mucilages pafs freely, without leaving any tafte in the mouth. A little foft extract of liquorice, joined to the mucilage, renders the compofition fufficiently grateful, with- out the inconveniences of the moreadhefive fweets. The quantity of an elecluary, direaed at a time, in extempo- raneous prefcription-, varies much according to its conftituent parts, but it is rarely lefs than the fize ofa nutmeg, or more than two or three ounces. ELECTUARIUM AROMATICUM. Edin. -Aromatic Elecluary. Take Of Aromatic powder, one part ; Syrup of orange peel, two parts. Mix and beat them well together, fo as to form an eleauary. Dub. Take of Conferve of orange peel, three ounces ; Cinnamon, Nutmeg, of each, in powder, half an ounce ; Saffron, of each two drachms ; Double refined fugar, one ounce ; Syrup of orange peel, as much as maybe neceffary to form the whole into an eleauary, by beating them well together. CONFECTIO AROMATICA. Lond. Aromatic ConfeBion. Take of Zedoary, in coarfe powder, Saffror>, of each half a pound ; Diftilled water, three pints. Macerate for twenty four hours; then prefs and ftrain. Reduce the ftrained liquor, by evaporation, to a pint and a half; to which add, Compound powder of crabs claws, fixteen ounces; Cinnamon, 612 Preparations and Compositions. [Part III. Nutmeg, of each two ounces ; Cloves, one ounce ; Smaller cardamom feeds, half an ounce ; Double refined fugar, two pounds. Reduce the aromatics together to a very fine powder, and form them into a confeaion, by adding the fugar. These compofitions are fufficiently grateful, and moderately warm. They are given in the form of a bolus, in dofes of from five grains to a fcruple, or upwards, as a cordial, or as a vehicle for more aaive fubftances. The fimple compofition of the Ed- inburgh College ferves all thefe purpofes as well as the compli- cated formula of the London College. ELECTUARIUM CASSIA FISTULA. Edin. EleBuary of Caffia, Take of Pulp of caffia fiflularis, fix ounces ; Pulp of tamarinds, Manna, each an ounce and a half ; Syrup of pale rofes, fix ounces. Having beat the manna in a mortar, diffolve it with a gentle heat, in the fyrup ; then add the pulps, and evaporate them with a regularly continued heat to the confiftence of an eleauary. Electuarium Cassia. Lond. Dub. EleBuary of Caffia. Take of The freffi extraaed pulp of caffia, half a pound ; Manna, two ounces ; Pulp of tamarinds, one ounce ; Rofe fyrup, half a pound. Beat the manna, and diffolve it over a flow fire in the rofe fyrup ; then add the pulps ; and, with a continued heat, evaporate the whole to the proper thicknefs of an eleauary. These compofitions are very convenient officinals, to ferve as a bafis for purgative eleauaries and other fimilar purpofes. The tamarinds give them a pleafant tafte, and do not fubjea them, as might be expeaed, to turn four. After ftanding for four months, the compofition has been found no fourer than when firft made. This eleauary, likewife is ufefully taken by itfelf, to the quanti- ty of two or three drachms occafionally, for gently loofening the belly in coftive habits. Chap. XXXVII.] Of Electuaries and Confections. 613 ELECTUAR1UM CAbSIA SENNA; olim, Electuari- um Lenitivum. Edin. ElECTUAKIcM Sennj;. Lond. EleBuary of Senna, communly called Lenitive EleBuary, Take of Senna, eight ounces ; Coriander feeds, tour ounces ; Liquorice, three ounces ; Figs, one pound ; Pulp of tamarinds, ------■ caffia, ■------prunes, each half a pound j Double refined fugar, two pounds and a half. Powder the fenna with the coriander feeds, and fift out ten ounces ot the nhxed powder. Boil the remainder with the figs and li- quorice, in four pints of (diftilled, Lond.) water, to one half ; then prefs out and ftrain the liquor. Evaporate this ftrained liquor to the weight of about a pound and a halt ; then add the fugar, and make a fyrup ; add this fyrup by degrees to the pulps, and, laftly, mix in the powder. Dub, Take of Senna leaves, in very fine powder, four ounces; Pulp of French prunes, one pound ; .------tamarinds, two ounces ; Molaffes, a pound and a halt ; Effential oil of caraway, two drachms. Boil the pulps in the fyrup to the thicknefs of honey ; then add the powders, and, when the mixture is cooled, add the oil; then beat them all well together, fo as to form an eleauary. This eleauary is a very convenient laxative, and has long been in common ufe among praaitioners. Taken to the fize of a nutmeg or more, as occafion may require, it is an excellent lax- ative for loofening the belly in coftive habits. The formula of the Dublin College is much more fimple and elegant than the other ; but might be rendered ftill more fo, by fubftituting an equivalent quantity of fine fugar for the molaffes. ELECTUARIUM CATECHU ; olim, Confectio Japon- ic a. Edin. EleBuary of Catechu, commonly called Japonic ConfeBwn, Take of Extraa of mimofa catechu, four ounces; 614 Preparations and Compositions. [Part. III. Kino, three ounces; Cinnamon, Nutmeg, each one ounce ; Opium diffufed in a fufficient quantity of Spanifh white wine, one drachm and a halt ; Syrup of dried roles boiled to the confiftence of honey, two pounds and a quarter. Reduce the folids to powder ; and having mixed them with the opium and fyrup, make them into an eleauary. Electuarium Catechu Compositum ; olim, Confec- tioJaponica. Dub. Compound EleBuary of Catechu, formerly Japonic ConfeBion. Tdke of Catechu, four ounces; Cinnamon, Nutmeg, each one ounce; Kino, three ounces ; Purified opium, diffufed in a fufficient quantity of Spanifh white wine, a drachm and a half ; Syrup of ginger, Syrup of orange peel, of each, evaporated to the confiftence of honey, fourteen ounces ; Tinaure ot Tolu, two drachms. Mix them, fo as to form an eleauary. These eleauaries, which do not differ in any material particu- lar, are extremely ufeful aftringent medicines, and are often given in dofes ot a tea fpoonful, frequently repeated, in cafes of diar- rhoea, &c. Ten fcruples contain one grain ot opium. ELECTUARIUM SCAMMONII. Lond. Dub. EleBuary of Scammony, Take of Scammony, in powder, one ounce and a half ; Cloves, Ginger, of each fix drachms ; Effential oil ot caraway, half a drachm ; (Syrup of rofes, as much as is fufficient, Lond.) Mix the fpices. powdered together, with the fyrup (of orange peel, Dub.) then add the fcammony, and laftly, the oil of caraway. This ejeauary is a warm, brifk purgative. A drachm and a half contains fifteen grains of fcammony. Chap. XXXVIII.] Of Troches. 615 ELECTUARIUM OPIATUM ; olim.ELECTUARiUM The. baicjm. Edin. Opiate EleBuary, commonly called Thebaic EleBuary. Take of Aromatic powder, fix ounces; Virginian fnake root, in fine powder, three ounces ; Opium diffufed in a fufficient quantity of Spanifh white wine, halt an ounce ; Syrup of ginger, one pound. Mix them, and form an eleauary. CONFECTIO OPIATA. Lond. ConfeBion of Opium. Take of Hard purified opium, powdered, fix drachms ; Long pepper, Ginger, Caraway feeds, of each two ounces ; Syrup ot white poppy, boiled to the confiftence of honey, three times the weight of the whole. Mix the purified opium with the fyrup heated ; then add the other ingredients, rubbed to powder. The aaion which thefe eleauaries will produce on the living fyftem, is abundantly apparent from the nature of their ingredi- ents. They are combinations ot aromatics with opium ; one grain of opium being contained in thirtyfix of the London con- feaion, and in tortythree of the Edinburgh eleauary. CHAP. XXXVIII. TROCHES. Troches and lozenges are compofed of powders made up with glutinous fubftances into little cakes, and afterwards dried. This form is principally made ufe ot for the more commodious exhibi- tion of certain medicines, by fitting them to diffolve flowly in the mouth, fo as to pafs by degrees into the ftomach ; and hence thefe preparations have generally a confiderable proportion of fu- 616 Preparations and Compositions. [Part lit* gar or other materials grateful to the palate. Some powders have likewife been reduced into troches, with a view to their preferva- tion ; though poffibly for no very good reafons ; for the moiften- ing, and afterwards drying them in the air, muft in this light be of greater injury, than any advantage accruing from this form can counterbalance. TROCH1SCI CARBONATIS CALCIS. Edin. Troches Carbonate of Lime. Take of Carbonate of lime, four ounces ; Gum Arabic, one ounce ; Nutmeg, one drachm ; Double refined fugar, fix ounces; Powder them together, and form them with water into a mafs for making troches. Trochisci Cret^e. Lond. Troches of Chalk. Take of Chalk, prepared, four ounces ; Crabs claws prepared, two ounces ; Cinnamon, half an ounce ; Double refined fugar, three ounces. Powder them, and add mucilage of gum arabic, and make tro- ches. These are ufed againft acidity of the ftomach, efpecially when accompanied with diarrhoea. TROCHISCI GLYCYRRH1ZA. Lond. Dub. Troches of Liquorice. Take of Extraa of liquorice, Double refined fugar, of each ten (fix, Dub.) ounces. Tragacanth, powdered, three (two Dub.) ounces. Powder them thoroughly, and make them into troches with rofe- water. ^ , r Edin. Take of Extraa of liquorice, Gum Arabic, each one part ; White fugar, two parts. Chap. XXXVIII.] Of Troches. 617 Diffolve them in warm water, and ftrain ; then evaporate the fo- lution over a gentle fire till it be of a proper confiftence for be- ing formed into troches. These are both agreeable peaorals, and may be ufed at pleaf- ure in trickling coughs. The former of thefe two receipts is the eafieft and beft mode of making thefe troches. Refined extraa of liquorice fhould be ufed ; and it is eafily powdered in the cold, alter it has been laid for fome days in a dry and rather warm place. The folution and fubfequent evaporation direaed by the Edin- burgh College is exceedingly troublefome, and apt to give them an empyreumatic flavor. TROCHISCI GLYCYRRHIZA cum OPIO. Edin. Liquorice Troches with Opium. Take of Opium, two drachms ; Tinaure of Tolu, half an ounce ; Common fyrup, eight ounces ; Extraa of liquorice, foftened in warm water, Gum Arabic, in powder, of each five ounces. Grind the opium well with the tinaure, then add by degrees the fyrup and extraa ; afterwards gradually fprinkle upon the mixture the powdered gum Arabic. Laftly, dry them fo as to form a mafs to be made into troches, each weighing ten grains. TrocHisci Glycyrrhizj: Compositi. Dub. Compound Troches of Liquorice. Take of Purified opium, two drachms ; Balfam of Peru, one drachm ; Tinaure of myrrh, three drachms. Triturate the opium in the balfam and tinaure mixed, until it be perfeaiy diffolved ; then gradually add ot Tinaure of Tolu, two drachms ; Extraa of liquorice, foftened in warm water, nine ounces. Beat them together thorougly, gradually adding of gum Arabic, in powder, five ounces, and form the mafs into troches, weigh- ing ten grains each. These direaions for preparing the above troches are fo full and particular, that no further explanation is neceffary. Six of the Dublin troches, and feven and a half of the Edinburgh, con- tain about one grain of opium. Thefe troches are medicines of approved efficacy in tickling coughs depending on an irritation of the fauces. Befides the mechanical effea of the invifcating mat- 618 Preparations and Compositions. [Part III. ters in involving acrid humors, or lining and defending the ten- der membranes, the opium muft no doubt have a confiderable fhare, by more immediately diminiffiing the irritability of the parts themfelves. TROCHISCI GUMMOSI. Edin, Gum Troches. Take of Gum Arabic, four parts ; Starch, one part ; Double refined fugar, twelve parts. Powder them, and make them into a proper mafs with rofewater, fo as to form troches. Trochisci Amyli. Lond. Troches of Starch. Take of Starch, one ounce and a half ; Liquorice, fix drachms ; Florentine orris, half an ounce ; Double refined fugar, one pound and a half. Powder them, and by means ot mucilage of gum tragacanth, make troches. They may be made, if fo chofen, without the orris. These compofitions are very agreeable peaorals, and may be ufed at pleafure. They are calculated for allaying the tickling in the throat which provokes coughing. Although the compofition in the London and Edinburgh phar- macopceias be fomewhat different, yet their effeas are very much the fame. TROCHISCI MAGNESIA. Lond. Troches of Magnefia, Take of Burnt magnefia, four ounces; Double refined fugar, two ounces ; Ginger, powdered, one fcruple. Triturate them together, and with the addition of the mucilage ©1 gum Arabic, make troches. v These are excellent antacids, and at the fame time tend to keep the bowels open. Chap. XXXIX.] Of Pills. 619 TROCH1SCI NITRATIS POTASSA, Edin. Troches of Nitrate of Potafs. Take of Nitrate of potafs, one part ; Double refined fugar, three parts* Rub together to powder and form them wkh mucilage of gum tragacanth into a mafs, to be divided into troches. Trochisci Nitri4 Lond, Troches of Nitre. Take of Purified nitre, powdered, four ounces ; Double refined fugar, powdered, one pound j Tragacanth, powdered, fix drachms. With the addition of water, make troches. This is a very agreeable form for the exhibition of nitre ; though, when the fait is thus taken without any liquid, (if the quantity be confiderable) it is apt to occafion uneafinefs about the ftomach, which can only be prevented by large dilution with aqueous liquors. TROCHISCI SULPHURIS. Lond. Troches of Sulphur, Take of Wafhed flowers of fulphur, two ounces ; Double refined fugar, four ounces. Rub them together, with a fufficient quantity of the mucilage of quince feeds, and make troches. This compofition is to be confidered only as an agreeable form for the exhibition of fulphur, no alteration or addition being here made to its virtues. CHAP. XXXIX. PILLS. To this form are peculiarly adapted thofe drugs which operate in a fmall dofe, and whofe naufeous and offenfive tafte or fmell require them to be concealed from the palate. Q2 620 Preparations and Compositions. [Part. III. Pills diffolve the moft difficultly in the ftomach, and produce the moft gradual and lafting effects of all the internal forms. This is, in fome cafes, of great advantage ; in others, it is a quality not at all defirable ; and fometimes may even be of dangerous confe- quence, particularly with regard to emetics ; which, if they pafs the ftomach undiffolved, and afterwards exert themfelves in the inteftines, operate there as violent cathartics. Hence emetics are among us fcarce ever given in pills ; and hence to the refinous and difficultly foluble fubftances, faponaceous ones ought to be added, in order to promote their folution. Gummy refins, and infpiffated juices, are fometimes foft enough Co be made into pills, without addition ; where any moifture is requifite, fpirit of wine is more proper than fyrups or conferves, as it unites more readily with them, and does not fenfibly increafe their bulk. Light dry powders require fyrup or mucilages ; and the more ponderous, as the mercurial and other metallic prepara- tions, thick honey, conferve, or extraas. Light powders require about half their weight of fyrup ; or of honey, about three fourths their weight ; to reduce them into a due confiftence for forming pills. Half a drachm of the mafs will make five or fix pills of a moderate fize. Gums and infpiffated juices, are to be firft foftened with the liquid prefcribed : The powders are then to be added, and the whole beat thoroughly together, tijl they be perfeaiy mixed. The maffes for pills are beft kept in bladders, which fhould be moiftened now and then with tome of the fame kind of liquid that the mafs was made up with, or with fome proper aromatic oil. PILULA ALOETICA. Edin. . Aloetic Pills. Take of Aloes in powder, Soap, equal parts. Beat them with fimple fyrup into a mafs fit for making pills. Dub. Take of Barbadoes aloes, in powder, one ounce; Extraa of gentian, halt an ounce ; Ginger, in powder, two drachms. Beat them together, and form a mafs with jelly of foap, (gelatina faponis.) Chap. XXXIX.] Of Pills. 621- PILULA ALOES COMPOSITA- Ldnd. Compound Pills of Aloes. Take of Socotorine aloes, powdered, one ounce ; Extraa of gentian, hall an ounce ; Oil of caraway feeds, two fcruples ; Syrup ot ginger, as much as is fufficient. Beat them together. Although foap can fcarcely be thought to facilitate the fo- lution of the aloes in the ftomach, as was fuppofed by Boerhaave and others, it is probably the moft convenient fubftance that can be added to give it the proper confiftence for making pills. When extraa of gentian is triturated with aloes, they react upon each other, and become too foft to form pills, fo that the addition of any fyrup to the mafs is perfeaiy unneceffary, unlefs at the fame time fome powder be added to give it confiftency, as is done by the Dublin College. Thefe pills have been much ufed as warm and ftomachic laxatives ; they are very well fuited for the 'eoftivenefs fo often attendant on people of fedentary lives. Like other preparations ot aloes, they are alfo ufed in jaundice, and in certain cafes of obftruaed menfes. They are feldom ufed for producing full purging ; but if this be required, a fcruple or half a drachm of the mafs may be made into pills of a moderate fize for one dofe. PILULA ALOES, cum ASS A FCETIDA. Edin. Pills of Aloes, with Affa Fcetida. Take of Socotorine aloes, Affa fcetida, Soap, equal parts. Form them into a mafs with mucilage of gum Arabic. These pills, in dofes of about ten grains twice a day, produce the moft falutary effeas in cafes of dyfpepfia, attended with fla- tulence and coftivenefs. PILULA ALOES, cum COLOCYNTHIDE. Edin. Pills of Aloes with Colocynth. Take of Socotorine aloes, Scammony, of each eight parts ; Colocynth, four parts ; Oil of cloves, Sulphate of potafs with fulphur, of each one part. *> frf- ^ 622 Preparations and Compositions. [Part III. .Reduce the aloes and fcammony into a powder with the fait; then let the colocynth, beat into a very fine powder, and the oil, be odded ; laftly, make it into a proper mafs with mucilage of gum Arabic. In thefe pills we have a very ufeful and aaive^purgative ; and where the fimple aloetic pill is not fufficient for obviating coftive- nefs, this will often effeaually anfwer the purpofe. Little of their aaivity c;in depend upon the fait which enters the compofition. Thefe pills often produce a copious difcharge in cafes of obftin- z\c coftivenefs, when taken to the extent only of five or ten grains ; but they may be employed in much larger dofes. They are, how- ever, feldom ufed with the view of producing proper catharfis. Halt a drachm of the mats contains about five grains of the colo- cynth, ten of the aloes, and ten of the fcammony. PILULA ALOES cum MYRRHA. Lond. Pills of Aloes with Myrrh. Take of Socotorine aloes, two ounces ; Myrrh, Saffron, of each one ounce ; Syrup of Saffron, as much as is fufficient. Powder the aloes and myrrh feparately ; and afterwards beat all the ingredients together into a mafs. Edin. Take of Socotorine aloes, two ounces ; Myrrh, one ounce ; Saffron, half an ounce. Beat them into a mafs with a proper quantity of fyrup. These pills have long continued in praaice, without any oth- er alteration than in the fyrup with which the mafs is made up, and in the proportion of faffron. The virtues of this medicine may be eafily underftood from its ingredients. Thefe pills given to the quantity of half a drachm or two fcruples, prove confidera- bly cathartic, but they anfwer much better purpofes in fmaller dofes as laxatives or alteratives. PILULA ASSA FCETIDA COMPOSITA. Edin. Compound Pills of Affafatida. Take of Affa fcetida, Galbanum, Myrrh, each eight parts ; Chap. XXXIX.] Of Pills. 6£3 Reaified oil of amber, one part. Beat them into a mafs with fimple fyrup. PILULA GALBANI COMPOSITA. Lond. _, Compound Pills of Galbanum- Take of Galbanum, Opopanax, Myrrh, Sagapenum, of each one ounce ; Affa fcetida, half an ounce ; Syrup of faffron, as much as is fufficient. Beat them together. These pills are defigned for antihyfterics and emmenagogue*, and are very well calculated for anfwering thofe intentions ; half a fcruple, a fcruple, or more, may be taken every night, or often- er. PILULA AMMONIARETI CUPRI. Edin. Pills of Ammomaret of Copper. Take of Ammoniaret of copper, fixteen grains; Bread crumb, four fcruples; Water ot carbonate of ammonia, as much as may be fufficient. Beat them into a mafs, to be divided into thirty two equal piiis. Each of thefe pills weighs about three grains, and contains fomewhat more than half a grain of the ammoniaret of copper. They feem to be the beft form of exhibiting this medicine. PILULA HYDRARGYRI. Edin. Mercurial Pdls, Take of Purified quickfilver, Conferve of red rofes, of each one ounce ; Starch, two ounces. Triturate the quickfilver with the conferve in a glafs mortar, till the globules completely difappear, adding occafionlly a little mucilage of gum Arabic ; then add the ftarch, and beat the whole with water into a mafs, which is to be immediately di- vided into four hundred and eighty equal pills. Lond, Take of Purified quickfilver, two drachms; \cr 3 624 Preparations and Compositions. [Pait III. Conferve of rofes, three drachms ; Liquorice, finely powdered, one drachm. Rub the quickfilver with the conferve until the globules difap- pear ; then, adding the liquorice powder, mix iliem together. Dub. Take of Quickfilver, Extraa of liquorice, each three drachms ; Liquorice root, in fine powder, a drachm and a half. Triturate the quickfilver with the extraa of liquorice, reduced with warm water to the confiftence of honey, until its globules difappear entirely ; then add the powder of liquorice, and as much water as fhall be fufficient to form it into a mafs. The common mercurial pill is one of the beft preparations of mercury, and may, in general, fupercede moft other forms of this medicine. In its preparation the mercury ;s minutely divided, and probably converted into the black oxide. To effea its me- chanical divifion it muft be triturated with fome vifcid fubftance. Soap, refin of guaiac, honey, extraa of liquorice, manna, and con- ferve of rofes, have all been at different times recommended. The foap and guaiac have been reje£ted on account of their being decompofed by thejuicesot the ftomach; and the honey, becaufe it was apt to gripe fome people. With regard tothe others, the grounds of feieaion are not well underftood, perhaps the acid contained in the conferveof rofes may contribute to theextindion of the mercu- ry. We learn when the mercury is completelyjextinguifhed, moft eafily, by rubbing a very little of ihe mafs with the point of the finger o i a piece ot paper, it no globules appear. As foon as this is the cafe, it is neceffary to mix with the mafs a proportion of fome dry powder, to give it a proper degree of confiftency. For tlm purpofe powder ot liquorice root has been commonly ufed; but it is extremely apt to become mouldy, and. to caufe the pills to fpoil. The Edinburgh College have, therefore, with great pro- priety, fubftituted for it ftarch, which is a very inalterable fub- ftance, and eafily procured at all times in a ftate of purity. It is neceffary to form the raafs into pills immediately, as it foon be- comes hard. One grain of mercury is contained in four grains of the Edinburgh mafs, in three of the London, and in two and a halt of the Dublin. The dofe of thefe pills muft be regulated by circumftances ; from two to fix five grain pills may be givea daily. Chap. XXXIX.] Of Pills. 625 PILULA OPII. Lond. Opium Pills. Take of Hard purified opium, powdered, two drachms ; Extraa of liquorice, one ounce. Beat them until they are perfeaiy united. PILULA OPIATA ; olim, Pilule Thejjaic.b. Edin. Pills of Opium, or Thebaic Pills. Take of Opium, one part ; Extraa of liquorice, feven parts; Jamaica pepper, two parts. *v Sotten the opium, and extraa feparately with diluted alcohol, and having beat them into a pulp, mix them ; then add the pepper reduced to powder ; and laftly, having beat them well together, form the whole into a mafs. These two compofitions, though differing in feveral particulars, are yet fundamentally very much the fame. The firft is a fimple opiate, in which every five grains of the rriafs contains one of opium ; and on the opium alone can we fuppofe that the aaivity of the medicine depends. The fecond contains one grain of opium in ten of the mafs. PILULA RHEI COMPOSITA. Edin. Compound Pills of Rhubarb, Take of Rhubarb, one ounce ; Socotorine aloes, fix drachms ; Myrrh, half an ounce ; Effential oil of peppermint, half a drachm. Make them into a mafs, with a fufficient quantity of fyrup of orange peel. This pill is intended for moderately warming and ftrengthen- ing the ftomach, and gently opening the belly. A fcruple of the mafs may be taken twice a day. PILULA SCILLA. Lond. PlLUL.E SCILLITIC/E. Dub. Squill Pills. Take of Freffi dried fquills, powdered, one drachm ; <£T4 626 Preparations and Compositions. [Part III. Ginger, powdered, Soap, of each three drachms ; Ammoniacum, two drachms ; Syrup ot ginger, as much as is fufficient. Beat them together (and form a mafs with jelly of foap, Dub.) PlLULjE SCILLIT1C7E. Edin. Squill Pills, Take of Dried root of fquills, in fine powder, one fcruple ; Gum ammoniac, Leffer cardamom feeds, in powder, Extraa of liquorice, each one drachm. Mix, and form them into a mafs with fimple fyrup. These are elegant and commodious forms for the exhibition of fquills, whether for promoting expeaoration, or with the other in- tentions to which that medicine is applied. As the virtue of the compound is derived chiefly from the fquills, the other ingredients are often varied in extemporaneous prefcription. PILULA STIBII COMPOSITA; olim, Pilule Plum- MERI. Dub. Compound Antimonial Pills, formerly Plummer's Pills. Take of Precipitated fulphur of antimony. Mild muriate of mercury, each three drachms; Extraa of gentian, Hard Spanifh foap, each one drachm. Let the mercury be triturated with the fulphur; then add the ex, traa, and form a mafs with jelly of foap. These pills were recommended to the attention of the public about forty years ago by Dr. Plummer, whofe name they long bore. He reprefented them in a paper which he publifhed in the Edinburgh Medical Effays, as a very ufeful alterative; and on his authority they were at one time much employed ; but they are now lefs extenfively ufed than formerly. Chap. XL.] Of Cataplasms. 627 CHAP. XL. CATAPLASMS. By cataplafms are in general underflood thofe external appli- cations which are brought to a due confiftence or form tor being properly applied, not by means ot oily or fatty matters, but by water or watery fluids. Ot thefe, not a few are had recourfe to in aaual praaice ; but they are feldom prepared in the fhops of the apothecaries ; and in fome of the beft modern pharmacopceias no formulae of this kind are introduced. The London and Dub- lin Colleges, however, although they have abridged the number of cataplafms, ftill retain a few ; and it is not without fome advan- tage that there are fixed forms for the preparation of them. CATAPLASMA ALUMINIS, Lond, Cataplafm of Alum. Coagulum Aluminosum. Dub. Alum Curd, Take The white of-two eggs, (any quantity, Dub.) Shake them with a piece of ajum till they be coagulated. This preparation is taken from Riverius. It is an ufeful af- tringent epithem for fore moift eyes. Where the complaint is violent, this preparation, after the inflammation has yielded a little to bleeding, is one ot the beft external remedies. It is to be fpread on lint and applied at bed time. CATAPLASMA CUMINI. Lond. Cataplafm of Cummin. Take of Cummin feed, one pound ; Bay berries, Drv leaves of water germander, or fcordium, Virginian fnake root, of each three ounces ; Cloves one ounce. 628 Preparations and Compositions. [Part III. Rub them all together to powder ; and with the addition of three times the weight of honey, make a cataplafm. This was intended as a reformation of the Theriaca Londinen- fts, which for tome time paft has been fcarcely otherwife ufed than as a warm cataplafm. In place of the numerous articles which formerly entered that compofition, only fuch ot iis in- gredients are retained as contribute moft to this intention : But even the article from which it now de'rives its name, as well as feveral othi rs which ftill enter, probably contribute very little to any medical properties it may poffefs. CATAPLASMA SINAPEOS. Lond. CATAPLASMA Si N API NUM. Dub. Mufiard Cataplafm. Take of Muftard feed, powdered, Crumb of bread, of each half a pound ; Vinegar, as much as is fufficient. Mix and make a cataplafm. Cataplasms of this kind are commonly known by the name of Sinapifms. They were formerly frequently prepared in a more complicated ftate, containing garlic, black foap, and other fimilar articles ; but the above fimple form will anfwer every purpofe which they are capable of accomplifhing. They are employed on'iy as ftimulants ; they olten inflame the part and raife blifters, but not fo perfeaiy as cantharides. They are frequently applied to the foles of the feet in the low ftate of acute difeafes, for raif- ing the pul(e and relieving the head. The chief advantage they have depends on the fuddennefs of their aaion. CHAP. XLI. LINIMENTS, OINTMENTS, CERATES, and PLASTERS. These are all combinations of fixed oil, or animal fat, with other fubftances, and differ from each other only in confiftence. Deyeux has, indeed, lately defined plafters to be combinations ot oil with metallic oxides ; but as this would comprehend many of Chap. XLI.] Of Liniments, &c. 629 our prefent ointments, and exclude many of our plafters, we fhall adhere to the old meaning of the terms.' Liniments are the thinneft of thefe compofitions, being only a little thicker than oil. Ointments have generally a degree of confiftence like that of butter. Cerates are firmer, and contain a larger proportion of wax. Plafters are the moft folid, and when cold fhould be firm, and fhould not adhere to the fingers ; but when gently heated, fhould become fufficiently foft to fpread eafily and ffiould then adhere to the fkin. Plafters derive their firmnefs, either from a large pro- portion of wax, or from the prefence of fome metallic oxide, fuch as that of lead. To prevent repetition, the Edinburgh College give the follow- ing canon for the preparation of thefe fubftances. In making thefe compofitions, the fatty and refinous fubftances are to be melted with a gentle heat, and then conftantly ftirred, adding, at the fame time, the dry ingredients, if there be any, until the mixture, on cooling, become ftiff. (Edin.) ADIPIS SUILLA, SEVIOUEOVILLI, PRAPARATIO. Lond. The Preparation of Hog's lard and Mutton fuet. Cut them into pieces, and melt them over a flow fire ; then fepa- rate them from the membranes by ftrainitig. These articles had formerly a place alfo among the prepara- tions of the Edinburgh College. But now they introduce them on- ly into their lift of the Materia Medica; as the apothecary will in general find it more for his intereft to purchale them thus pre- pared, than to prepare them for himfelf; for the procefs requires to be very cautioufly conduaed, to prevent the fat from burning or turning black. LINIMENTUM SIMPLEX, Edin. Simple Liniment. Take of Olive oil, four parts; * White wax, one part. This confifts of the fame articles which form the Unguentum fimplex of the Edinburgh Pharmacopoeia, but merely in a differ- ent proportiora, fo as to render the compofition thinner ; and where a thin confiftence is requifite, this may be confidered as a very elegant and ufeful application. 630 Preparations and Compositions. [Part III. UNGUENTUM ADIPIS SUILLA. Lond. Ointment of Hog's lard. Take of Prepared hog's lard, two pounds ; Rofe water, three ounces. Beat the lard with the rofe water until they be mixed ; then melt the mixture with a flow fire, and fet it apart that the water may fubfide ; atter which, pour of the lard from the water, conftant- ly ftirring until it be cold. In the laft edition of the London Pharmacopoeia, this was ftyled Unguentum fimplex, the name given by the Edinburgh College to the following. UNGUENTUM SIMPLEX. Edin. Simple Ointment. Take of Olive oil, five parts ; White wax, two parts. Both tjiefe ointments may be ufed for foftening the fkin and healing chaps. The laft is, however, preferable, as bei; g mere fteadily of one uniform confiftence. For the fame reafon it ic alfo to be preferred as the bafis ot other more compounded ointments. UNGUENTUM SPERMATIS CETI. Lond. Dub. Ointment of Spermaceti. Take of Spermaceti, fix drachms ; White wax, two drachms; Olive oil, three ounces. Melt them together over a flew fire, ftirring them conftantly and brifkly until they be cold. This had formerly the name of Linimentum album, and it is fierhaps only in confiftence that it can be confidered as differing rom the unguentum fimplex, already mentioned, or the ceratum fimplex, afterwards to be taken notice of. UNGUENTUM CERA. Lond- Dub. Wax Ointment. Take ot White wax, four ounces; Spermaceti, three ounces ; Olive oil, onv'pint (fourteen ounces, Dub.) Chap. XLI.] Of Liniments, he. 631 Stir them, after being melted with a flow fire, conftantly and brifkly, until cold. This ointment had formerly the title of Unguentum album in the London Pharmacopoeia. It differs very little from the Un- guentum fimplex of the Edinburgh Pharmacopoeia, and in noth- ing from the Unguentum fpermatis ceti of the other Pharmaco- poeias, excepting that in this ointment the proportion of wax is four times greater. It is an ufeful cooling ointment for excoriations and other frettings of the fkin. SERATUM>SIMPLEX. Edin. Simple Cerate. Take of Olive oil, fix parts ; White wax, tiiree parts ; Spermaceti, one part. This differs from the fimple ointment in containing a greats- proportion of wax to the oil, and in the addition of the fperma- ceti. But by thefe means it obtains only a more firm confiftence without any effential change of properties. CERATUM SPERMATIS CETI. Lond. Dub. Cerate of Spermaceti. Take of Spermaceti, half an ounce ; White wax, two ounces ; Olive oil, four ounces. Melt them together, and ftir until the cerate be cold. This had formerly the name of Ceratum album, and it differs in nothing from the Unguentum fpermatis ceti, or Linimentum al- bum, as it was formerly called, excepting in confiftence, both the wax and trie fpermaceti bearing a greater proportion to the oil. UNGUENTUM RES1NA FLAVA. Lond. Dub. Ointment of Yellow Refin. Take of Yellow refin, Yellow wax, of each one pound ; Olive oil, one,pint (feven ounces, Du.) Melt the refin and wax with a flow fire ; then add the oil and ftrain the mixture while hot. 632 Preparations and Compositions. [Part III. UNGUENTUM RESINOSUM. Edin. Refinous Ointment, Take of Hog's lard, eight parts ; White refin, five parts ; ^ Yellow wax, two parts. These are commonly employed in draftings, for digefting, cleanfing, and incarnating wounds and ulcers. CERATEM RES1NA FLAVA. Lond. Dub Cerate cf Yellow Refin. Take of Ointment of yellow refin, half a pound ; Yellow wax, one ounce. Melt them together, and make a cerate. This had formerly the name of Unguentum citrinum. It is no otherwife different from the Yellow bafilicum, or Ungentum re- tinae flavas, than being ofa ftiffer confiftence, which renders it for fome purpofes more commodious. EMPLASTRUM CERA. Dub. Emplastrum Cer,e Compositum. Lond. Compound Wax Plafter. Take of % Yellow wax, Prepared mutton fuet, of each three pounds; Yellow refin, one pound. Melt them together, and ftrain the mixture while it is fluid. EMPLASTRUM SIMPLEX, sive EMPLASTRUM CE. REUM. Edin. Simple or Wax Plafter. Take of Yellow wax, three parts ; Mutton fuet, White refin, each two parts. This plafter had formerly the title of Emplaftrum attrahens, and was chiefly employed as a dreffing after blifters, to fupport fome difcharge, and it is a very well contrived plafter for that pur- pofe. Sometimes, however, it irritates too much on account of the refin ; and hence, when defigned only for dreffing blifters, the Chap. XLI.] Of Liniments, &c, 633 refin ought to be entirely omitted, unlefs where a continuance of the pain and irritation, excited by the veficatory, is required. In- deed, plafters of any kind are not very proper for dreffing blif- ters ; their confidence makes them fit uneafv, and their adhefive- nefs renders the taking them off painful. Ceiates, which are foft- er and lefs adhefive, appear much more eligible ; tbe Ceratum fpermatis ceti will ferve for general ufe ; and for fome particular purpofes, the Ceratum refinae flavae may be applied. UNGUENTUM ELEMI. Dub. Unguentum Elemi Compositum. Lond. Compound Ointment of Elemi. Take of Elemi, one pound ; Turpentine, ten ounces ; Mutton fuet, prepared, two pounds; Olive oil, two ounces. Melt the elemi with the fuet ; and having removed it from the fire, mix it immediately with the turpentine and oil ; after which ftrain the mixture. This ointment, formerly known by the name of Linimentum Arcai, has long been ufed for digefting, cleanfing, and incarnat- ing ; and for thefe purpofes is preferred by fome furgeons to all the other compofitions of this kind. UNGUENTUM PICIS. Lond. Dub. Tar Ointment. Take of Tar, Mutton fuet, prepared, of each half a pound. Melt them together, and ftrain. Edin. Take of Tar, five parts ; Yellow wax, two parts. These compofitions cannot be confidered as differing effential- ly from each other. As far as they have any peculiar aaivity, this entirely depends on the tar. From the empvreumatic oil and faline matters which it contains, it is undoubtedly of fome ac- tivity. Accordingly, it has been fuccefsfully employed againft fome cutaneous affeaions, particularly tinea capitis. 634 Preparations and Compositions. [Part III. EMPLASTRUM PICIS BURGUNDICA. Dub. EMPLASTRUM PlCls COMPOSITUM. Lond. Compound Burgundy Pitch Plafter. Take of Burgundy pitch, two pounds ; Ladanum, (Galbanum, Dub.) one pound ; Yellow refin, Yellow wax, of each four ounces ; Expreffed oil of mace, one ounce. To the pitch, refin, and wax, melted together, add firft the lada- num, (galbanum, Dub.) and then the oil of mace. EMPLASTRUM CUMINI. Lond. Cummin Plafter. Take of Cummin feeds, Caraway feeds, Bay berries, of each three ounces ; Burgundy pitch, three pounds ; Yellow wax, three ounces. Melt the pitch and wax together, and mix with them the reft of the ingredients, powdered, and make a plafter. This plafter ftands recommended as a moderately warm difcu- tient ; and is direfled by fome to be applied to the hypogaftric re- gion, tor ftrengthening the vifcera, and expelling flatulencies ; but it is a matter of great doubt, whether it derives any virtue, ei- ther from the article from which it is named, or from the caraway feeds or bay berries which enter its compofition. EMPLASTRUM LADANI COMPOSITUM. Lond. Compound Ladanum Plafter. Take ot Ladanum, three ounces ; Frankincenfe, one ounce ; Cinnamon, powdered, Expreffed oil of mace, of each half an ounce ; Effential oil of mint, one drachm. To the melted frankincenfe, add firft the ladanum, foftened by heat; then the oil of mace. Mix thefe afterwards with the cinnamon and oil of mint, and beat them together, in a warm mortar, into a plafter. Let it be kept in a clofe veffel. This has been confidered as a very elegant ftomach plafter. It is contrived fo as to be eafily made occafionally, (for thefe kinds Chap. XLI.] Of Liniments, fcc 635 of compofitions, on account of their volatile ingredients, are not fit for keeping) and to be but moderately adhefive, fo as not to offend the fkin, and that it may, without difficulty, be frequently renewed ; which thefe forts of applications, in order to their pro- ducing any confiderable effea, require to be. UNGUENTUM SAMBUCI. Lond. Unguentum Sambucinum. Dub. Elder Ointment. Take of Elder flowers, four pounds ; Mutton fuet, prepared, three pounds ; Olive oil, one pint. Boil the flowers in the fuet and oil, till they be almoft crifp ; thea ftrain with expreffion. ' Compositions of this kind were formerly very frequent; but vegetables, by boiling in oils, impart to them nothing but a little mucilage, which changes the greafy oils to drying oils, and any refin they may contain ; but that alfo is never in fuch quan- tity as to affea the nature of the oil. We, therefore, do not fup- pofe that this ointment poffeffes any properties different from a fimple ointment ot the fame confiftency. UNGUENTUM CANTHARIDIS. Lond. Unguentum Cantharidum. Dub. Ointment of Spanifh Flies. Take of Spanifh flies, powdered, two ounces; Diftilled water, eight ounces, (water, nine ounces, Dub.) Ointment of yellow refin, eight ounces. Boil the water with the Spanifh flies to one half, and ftrain. To the ftrained liquor add the ointment of yellow refin. Evapo- rate this mixture in a water bath, faturated with fea fait, to the thicknefs of an ointment. UNGUENTUM INFUSI MELOES VESICATORII; vul- go, Unguentum Epispasticum Mitius. . Edin. Ointment of Infufion of Cantharides, commonly called Mild Epu fpaflic Ointment. Take of Cantharides, White refin, Yellow wax, each one part; R r 636 Preparations and Compositions. [Part III. Hogs lard, Venice turpentine, each two parts; Boiling water, four parts. Infufe the cantharides in the water for a night ; then ftrongly prefs out and ftrain the liquor, and boil it with the lard till the water be confumed ; then add the refin and wax ; and when thefe are melted, take the ointment off the fire and add the tur- pentine. These ointments, containing the foluble parts of the canthari- des, uniformly blended with the other ingredients, are more com- modious, and in general occafion lefs pain, though little lefs effea- ual in their aaion, than the compofitions with the fly in fubftance. This, however, does not uniformly hold ; and accordingly the Edinburgh College, with propriety, introduce the following. UNGUENTUM PULVERIS MELOES VESICATORII ; olim, Unguentum Epispasticum Fortius. Edm. Ointment of the Powder of Spanifh Flies, formerly Stronger Epif- paftic Ointment. Take of Refinous ointment, feven parts ; Powdered cantharides, one part. This ointment is employed in the dreffings for blifters, intend- ed to be made perpetual, as they are called, or to be kept running for a confiderable time, which in many chronic, and fome acute cafes, is of great fervice. Particular care fhould be taken, that the cantharides employed in thefe compofitions be reduced into very fubtile powder, and that the mixtures be made as equal and uniform as poffible. But with thefe precautions, there are fome particular habits in which this ointment operates with even lefs pain than the former, while at the fame time it is generally more effeaual. CERATUM CANTHARIDIS. Lond. Dub.' Cerate of Cantharides. Take of Cerate of fpermaceti, foftened with heat, fix drachms, (one ounce, Dub.) Spanifh flies, finely powdered, one drachm, (four fcruples, Dub.) Mix them. Under this form cantharides may be made to aa to any extent that is requifite. It may fupply the place either ot the bliftering plafter or ointment; and there are cafes in which it is preferable to either. It is particularly more convenient than the ernplaftrum Chap. XLI.] Of Liniments, &c. 637 cantharidum, where the fkin to which the blifter is to be applied is previoufly much affeaed, as in cafes ot fmall pox ; and in fup- porting a drain under the form of iffuc, it is lefs apt to fpread than the fofter ointment. EMPLASTRUM CANTHARIDIS. Lond. Dub. Plafter of Spanifh Flies. Take of »Spanifh flies, finely powdered, one pound ; Wax plafter, two pounds ; Prepared hogs lard, half a pound. Having melted the plafter and lard, fprinkle and mix in the flies, a little before they become firm. Emplastrum Meloes Vesicatorii ; olim, Emplas* trum Vesicatorium. Edin. Plafter of Spanifh Flies, formerly Bliftering Plafter. Take of «. Mutton fuet, Yellow wax, White rofin, Cantharides, each equal weights. Beat the cantharides into a fine powder, and add them to the other ingredients, previoufly melted, and removed from the fire. Both thefe formulas are very well fuited to anfwer the inten- tion in view, that of exciting blifters ; for both are of a proper confiftence and fufficient degree of tenacity, which are here the only requifites. Cantharides of good quality, duly applied to the fkin, never fail of producing blifters. When, therefore, the de- fired effea does not take place, it is to be afcribed to the flies ei- ther being faulty at firft, or having their aaivity afterwards de- ftroyed by fome accidental circumftance ; fuch as too great heat in forming, or in fpreading the plafter, or the like. EMPLASTRUM MELOES VESICATORII COMPOSI- TUM. Edin. Compound Plafter of Spanifh Flies. Take of Burgundy pitch, Cantharides, each twelve parts; Yellow wax, four parts; Subacetite of copper, two parts ; Muftard feed, Black pepper, each one part. Having firft melted the pitch and wax, add the turpentine, and to thefe, in fufion, and ftill hot, add the other ingredients, reduced 638 Preparations and Compositions, [Part III. to a fine powder and mixed, and ftir the whole carefully together, fo as to form a plafter. This is fuppofed to be the moft infallible bliftering plafter. It certainly contains a fufficient variety of ftimulating ingredients.. UNGUENTUM HELLEBORI ALBI. Lond. Dub. Ointment of White Hellebore. Take of White hellebore, one ounce ; Ointment of (hogs lard, Dub ) four ounces j Effence of lemon, half a fcruple. Mix, and make an ointment. White hellebore externally applied has long been celebrated in the cure of cutaneous difeafes. UNGUENTUM SULPHURIS. Lond. Dub. Sulphur Ointment. Take of Ointment of hogs lard, half a pound (five ounces, Dub.) Flowers of fulphur, four (three, Dub.) ounces. Mix them, and make an ointment. Edin. Take of Hogs lard, four parts; Sublimed fulphur, one part. To each pound of this ointment add, Volatile oil of lemons, or -----------of lavander, half a drachm. Sulphur is a certain remedy for the itch, more fafe than mer- cury. A pound of ointment ferves for four unaions. The pa- tient is to be rubbed every night, a fourth part of the body at each time. Though the difeafe may be thus cured by a fingle appli- cation, it is in general advifable to touch the parts moft affecled lor a few nights longer, and to conjoin with the friaions the inter* rial ufe of fulphur. UNGUENTUM ACIDI NITROSI. Edin. Ointment of Nitrous Acid. Take of Hogs lard, one pound ; Nitrous acid, fix drachms. Mix the acid gradually with the melted axunge, and diligently beat the mixture as it cools. Chap. XLI.] Of Liniments, Sec. 639 The axunge in this ointment feems to be oxidized ; for during the aftion of the acid upon it, there is a great deal of nitric oxide gas difengaged. It acquires a yellowith color, and a firmer con- fiftency ; and forms an excellent and cheap fubftitute, in flight herpetic and other cutaneous affeaions, for the ointment of nitrate of mercury, EMPLASTRUM OXIDI PLUMBI SEMIV1TREI ; olim, EMPLASTRUM COMMUNE. Edin. Plafter of the Semi vitrified Oxide of Lead, formerly Common Plaf- ter. Take of Semi vitrified oxide of lead, one part ; Olive oil, two parts. Boil them, adding water, and conftantly ftirring the mixture till the oil and litharge be formed into a plafter. EMPLASTRUM LITHARGYRI. Lond. Dub, Litharge Plafter. Take of Litharge, in very fine powder, five pounds ; Olive oil, a gallon, (nine pounds, Dub.) Water, two pints, (two pounds, Dub.) Boil them with a flow fire, conftantly ftirring until the oil and li- tharge unite, fo as to form a plafter. (But it will be proper to add more boiling water, if th» water that was firft added be, nearly confumed before the end of the procefs. Lond.) • Oxides of lead, boiled with oils, unite with them into a plaf- ter of an excellent confiftence, and which makes a proper bafis for feveral other plafters. In the boiling of thefe compofitions, a quantity of water muft be added, to prevent the plafter from burning and growing black. Such water as it may be neceffary to add during the boiling, muft be previoufly made hot ; for cold liquor would not only prolong the procefs, but likewife occafion the matter to explode, and be thrown about with violence, to the great danger of the operator : This accident will equally happen upon the addition of hot water, if the plafter be extremely hot. It is therefore better to remove it from the fire a little before each addition of water. Thefe plafters, which have been long known under the name of Diachylon, are common applications in excoriations of the fkin, flight fleffi wounds, and the like. They keep the part foft and fomewhat warm, and defend it from the air, which is all that can be expeaed in thefe cafes from any plafter. (840 Preparations and Compositions. [Part III. EMPLASTRUM RESINOSUM ; vulgo, Emplastrum Ad- HjESIVUM. Edin. Refinous Plafter, commonly called Adhefive Plafter. Take of Plafter of femivitrified oxide of lead, five parts; White refin, one part. Melt them together, and make a plafter. Emplastrum Lithargyri cum Resina. Lond. Litharge Plafler with Refin. Take of Litharge plafter, three pounds ; Yellow refin, half a pound. To the litharge plafter, melted with a very flow fire, add the pow- dered refin ; mix them well, and make a plafter. These plafters are chiefly ufed as adhefives for keeping on other dreffiiigs, for retaining the edges of recent wounds together, when we are endeayering to cure them by the firft intention, and for giving mechanical fupport to new fleffi, and contraaing the fize of ulcers, in the manner recommended by Mr. Bayston, for the cure of ulcers of \be legs. EMPLASTRUM ASSA FOETIDA; vulgo, Emplastrum Antihystericum. Edin. Plafler of Affa fcetida, commonly called Antihyfieric Plafler. Take of Plafter of femivitrified oxide of lead. Affa fcetida, each two parts ; Galbanum, Yellow wax, each one part. This plafter is applied to the umbilical region, or over the whole abdomen, in hyfieric cafes ; and fometimes with good ef- fect ; but probably jnore from its effea as giving an additional degree of heat to the part, than from any influence derived from the fetid gums. EMPLASTRUM GUMMOSUM. Edin. Gum Plafter. Take of Plafter of femivitrified oxide of lead, eight parts • Gum ammoniacum, Galbanum, Yellow wax, each one part. Chap. XLI. Of Liniments, he. 641 EMPLASTRUM LYTHARGYRI COMPOSITUM. Lond. Compound Plafler of Litharge. Take of Litharge plafter, three pounds ; Strained galbanum, eight ounces ; Turpentine, ten drachms ; Frankincenfe, three ounces. The galbanum and turpentine being melted, mix with thera the powdered frankincenfe, and afterwards the litharge plafter, melted alfo with very flow fire, and make a plafter. Both thefe plafters are ufed as digeftives and fuppuratives ; particularly in abfceffes, after a part of the matter has been ma- turated and difcharged, for fuppurating or difcuffing the remain- ing hard part ; but it is very doubtful whether they derive any advantage from the gums entering their compofition. CERATUM SAPONIS, Lond. Dub. Soap Serate, Take of Soap (hard Spanifh foap, Dub.) eight ounces j Yellow wax, ten ounces ; Litharge, powdered, one pound ; Olive oil, one pint (fourteen ounces, Dub.) Vinegar, one gallon (eight pounds, Dub.) Boil the vinegar with the litharge, over a flow fire, conftantly ftir- ring, until the mixture unites and thickens ; then mix Li the other articles, and make a cerate. Notwithstanding the name, this cerate may rather be confidered as another faturnine application ; its aaion depending very little on the foap. EMPLASTRUM SAPONIS. Lond. Emplastrum Saponaceum, Dub. Soap Plafter. Take of Soap, one part ; Litharge plafter, fix parts. Mix the foap with the melted litharge plafter, and boil them fo the thicknefs ofa plafter. 83T4 642 Preparations and Compositions. [Part III. Emplastrum Saponaceum. Edin. Saponaceous Plafler, Take of Plafter of femi vitrified oxide of lead, four parts ; Gum plafter, two parts ; Soap, fliced, one part. To the plafters, melted together, add the foap ; then boil for a little, fo as to form a plafter. These plafters have been fuppofed to derive a refolvent power from the foap ; and in the laft, the addition of the gums is fup- pofed to promote the refolvent virtue of the foap ; but it is a mat- ter of great doubt, whether they derive any material advantage from either addition. EMPLASTRUM THUR1S COMPOSITUM. Lond. Compound Frankincenfe Plafler. Take of Frankincenfe, half a pound ; Dragons blood, three ounces ; Litharge plafter, two pounds. To the melted litharge plafter add the reft, powdered. It has been fuppofed that plafters compofed of ftyptic medicines conftringe and ftrengthen the part to which they are applied,, but on no very juft foundation ; for plafters in general relax rather than aftringe, the unauous ingredients neceflary in their compofi- tion counteraaing and deftroying the effea of the others. If conftantly worn with a proper bandage, it will, in children, frequently do fervice, though, perhaps, not fo much from any ftrengthening quality of the ingredients, as from its being a foft, clofe, and adhefive covering. UNGUENTUM OXIDI PLUMBI ALBI; vulgo, Unguen- tum Album. Edin. Ointment of White Oxide of Lead, formerly White Ointment. Take of Simple ointment, five parts ; White oxide of lead, one part. This is a cooling deficcative ointment, of great ufe when ap- plied to excoriated furfaces. Chap. XLI.] Of Liniments, kc. 643 UNGUENTUM ACETICIS PLUMBI; vulgo.U'NGUENTUM Saturn in um. Edin. Ointment of Acetite Lead, formerly Saturnine Ointment. Take of Simple ointment, twenty parts. Acetite of lead, one part. UNGUENTUM CERUSSA ACETATA. Lond. Dub. Ointment of Acetated Cerufe. Take of Acetated cerufe, two drachms ; White wax, two ounces ; Olive oil, half a pint (halt a pound, Dub.) Rub the acetated cerufe, previoufly powdered, with fome part of the olive oil ; then add it to the wax, melted with the remain- ing oil. Stir the mixture until it be cold. These are alfo excellent cooling ointments, of the greateft ufe in many cafes. CERATUM LITHARGYRI ACETATI COxMPOSlTUM. Lend. Ceratum Lithargyri Acetati. Dub, Compound Cerate of Acetated Litharge, Take of Water of acetated litharge, two ounces and a half ; Yellow wax, four ounces ; Olive oil, nine ounces ; Camphor, half a drachm. Rub the camphor with a little of the oil. Melt the wax with the remaining oil, and as foon as the mixture begins to thicken, pour in by degrees the water of acetated litharge, and ftir con- ftantly until it be cold ; then mix in the champhor previoufly rubbed with oil. This application has been rendered famous by the recommen- dations of Mr. Goulard. It is unqueftionably in many cafes very ufeful ; it cannot, however, be confidered as varying effentially from the faturnine ointments, already mentioned. It is employ- ed with nearly the fame intentions, and differs from them chiefly in confiftence. UNGUENTUM HYDRARGYRI ; vulgo, Unguentum Coeruleum. Edin. Ointment of Quickfilver, commonly called Blue Ointment. Take of Quickfilver, 644 Preparations and Compositions. [Part III. Mutton fuit, each one part ; Hogs lard, three parts. Rub them carefully in a mortar till the globules entirely difap- pear. This ointment may alfo be made with double or treble the quan- tity of quickfilver. UNGUENTUM HYDRARGYRI FORTIUS. Lond. Dub. Stronger Mercurial Ointment. Take of Purified quickfilver, two pounds ; Prepared hogs lard, twenty three ounces ; Prepared mutton fuet, one ounce. ' Firft triturate the quickfilver with the fuit and a little of the hogs lard, until the globules be extinguifhed ; then add the reft of the lard, and form it into an ointment. Unguentum Hydrargyri Mitius. Lond. Dub. Milder Mercurial Ointment. Take of The ftronger ointment of quickfilver, one part ; Hogs lard, prepared two parts. Mix them. UNGUENTUM OXIDI HYDRARGYRI CINEREI. Edin. Ointment of Grey Oxide of Quickfilver. Take of Grey oxide of quickfilver, one part; Hogs lard, three parts. These ointments are principally employed, not with a view to their topical aaions, but with the intention of introducing mercury in an aclive ftate into the circulating fyftem; which may be ef- feaed by gentle friaion on the found fkin of any part, particu- larly on the infide of the thighs or legs. For this purpofe, thefe fimple ointments are much better fuited than the more compound- ed ones with turpentine and the like, formerly employed. For, by any acrid fubftance, topical inflammation is apt to be excited, preventing further friaion, and giving much uneafinefs. To avoid this, it is neceffary, even with the mildeft and weakeft oint- ment, to change occafionally the place at which the friaion is per- formed. It is requifite that the ointments, in which the mercury is ex- tinguifhed by trituration, fliould be prepared with very great care ; for upon the degree of triture which has been employed, the Chap. XLL] Of Liniments, he. 645 aftivity of the mercucy very much depends. The addition of the mutton fuet, now adopted by both Colleges, ts an advantage to the ointment, as it prevents it from running into the ftate of oil, which the hogs lard alone, in warm weather, or in a warm chamber, is fometimes apt to do, and which is followed by a fepa- ration of parts. We are even inclined to think, that the propor- tion of fuet direaed by the London College is too fmall for this purpofe, and indeed feems to be principally intended for the more effeaual triture of the mercury : But it is much more to be regret- ted, that in a medicine of fuch aaivity, the Colleges fhould not have direaed the fame proportion of mercury to the fatty matter. If the efficacy of the ointment prepared with the grey oxide were fufficiently eftablifhed, the facility and certainty of its pre- paration would be attended with great advantages. EMPLASTRUM HYDRARGYRI. Edin. Plafter of Quickfilver, Take of Olive oil, White refin, each one part; Quickfilver, three parts ; Plafter of femivitrified oxide of lead, fix parts. Melt the oil and refin together, and when this mixture is cold, let the quickfilver be rubbed with it till the globulus difappear ; then add by degrees the litharge plafter, melted, and let the whole be accurately mixed. EMPLASTRUM AMMONIACI cum HYDRARGYRO. Lond. Plafler of Gum Ammoniac with Quickfilver. Take of Gum ammoniac, ftrained, one pound ; Purified quickfilver, three ounces ; Sulphurated oil, a drachm, or as much as may be neceffary. Triturate the quickfilver with the fulphurated oil, until its glo- bules difappear ; then gradually add the gum ammoniac melt- ed, and mix them. EMPLASTRUM LITHARGYRI cum HYDRARGYRO. Lond. Litharge Plafler with Quickfilver. Take of Litharge plafter, one pound ; Purified quickfilver, three ounces ; Sulphurated oil, one drachm, or what is fufficient, 646 Preparations and Compositions. [Part III. Make the plafter in the fame manner as the ammoniacum plafter with quickfilver. These mercurial plafters are confidered as powerful refolvents and difcutients, acling with much greater certainty tor thefe in- tentions than any compofition of vegetable fubftances alone ; the mercury exerting itfelf in a confiderable degree, and being fome- times introduced into the habit in fuch quantity as to affe& the mouth. Pains in the joints and limbs from a venereal caufe, nodes, tophi, and beginning indurations are faid to yield to them fometimes. UNGUENTUM CALCIS HYDRARGYRI ALBI, Lond. Ointment of the White Calx of Quickfilver. Take of The white calx of quickfilver, one drachm ; Ointment of hogs lard, one ounce and a half ; Mix, and make an ointment. This is a very elegant mercurial ointment, and frequently made ufe of in the cure of obftinate cutaneous, affeaions. UNGUENTUM OXIDI HYDRARGYRI RUBRI. Edin. # Ointment of Red Oxide of Qjiickfilver. Take of Red oxide of quickfilver by nitrous acid, one part ; Hogs lard, eight parts. This is an excellent ftimulating ointment, often of very great fervice in indolent ill conditioned fores, when we wiffi to excite them to greater aaion. If it prove too ftimulating, it may be di- luted with axunge ; and in this ftate it is often applied to the eye- lids in chronic ophthalmia. UNGUENTUM NITRATIS HYDRARGYRI ; vulgo, Un- guentum Citrinum. Edin. Ointment of Nitrate of Quickfilver, commonly called Yellow Oint- ments Unguentum Hydrargyri Nitrati. Lond. Dub. Ointment of Nitrated Quickfilver. Take of : Quickfilver, one part ; Chap. XLI.] Of Liniments, &e. 647 Nitrous acid, two parts ; Hogs lard, twelve parts. Diffolve the quickfilver in the nitrous acid, by digeftion in a fand- heat ; and, while the folution is very hot, mix with it the lard, previoufly melted by itfelf, and juft beginning to grow ftiff. Stir them brifkly together in a marble mortar, fo as to form the whole into an ointment. UNGUENTUM N1TRAT1S 'HYDRARGYRI M1TIUS. Edin. Milder Ointment of Nitrate of Quickfilver. This is prepared in the fame way, with three times the quantity of hogs lard. Although the aaivity of the nitrated quickfilver be very confiderably moderated by the animal fat with which it is after- wards united, yet it ftill affords us a very aaive ointment ; and, as fuch, it is frequently employed with fuccefs in cutaneous and other topical affeaions. In this condition, however, the mercury does not fo readily enter the fyftem, as in the preceding form. Hence it may even be employed in fome cafes with more free- dom ; but in other inftances it is apt to excoriate and inflame the the parts. On this account a reduaion of its ftrength is fome- times requifite ; and it is often alfo neceffary, from the hard con- fiftence which it gradually acquires, in confequence of the aaioil of the acid on the lard. » UNGUENTUM SUBACETITIS CUPRI. Edin, Ointment ofSubacetite of Copper. Take of Refinous ointment, fifteen parts; Subacetite of copper, one part. This ointment is ufed for cleanfing fores, and keeping down fungous fleffi. Where ulcers continue to run from a weaknefs in the veffels of the parts, the tonic powers of copper promife con- fiderable advantage. It is alfo frequently ufed with advantage in cafes of ophthalmia, depending on fcrofula, where the palpebrae are principally affea- ed ; but when it is to be thus applied, it is in general requifite that it ffiould be fomewhat weakened by the addition ofa propor- tion of fimple ointment or hogs lard. An ointment fimilar to the above, and celebrated for the cure of fuch inftances of ophthal- mia, has long been fold under the name of Smellom's eyefalve. 648 Preparations and Compositions. [Part. III. UNGUENTUM OXID1 ZINCI IMPURI; olim, Unguen- tum TuTiiE. Edin. Ointment of Impure Oxide of Zinc, formerly Ointment of Tutty. Take of Simple liniment, five parts ; Prepared impure oxide of zinc, one part. UNGUENTUM TUTIA. Lond. Dub. Ointment of Tutty. Take of Prepared tutty, Ointment of fpermaceti, (hogs lard, Dub.) as much as may be fufficient. Mix them fo as to make a foft ointment. UNGUENTUM OXIDI ZINCI. Edin. Ointment of Oxide of Zinc. Take of Simple liniment, fix parts ; Oxide of zinc, one part. These ointments are chiefly ufed in affeaions of the eye, par- ticularly in thofe cafes where rednefs arifes rather trom relaxa- tion than from aaive inflammation. CERATUM CARBONATIS ZINCI IMPURE Edin. Cerate of Impure Carbonate of Zinc. Take of Simple cerate, five parts ; Prepared impure carbonate of zinc, one part. CERATUM LAPIDIS CALAMINARIS ; olim, Ceratum Epuloticum. Lond. Dub. Calamine Cerate, formerly Epulotic Cerate. Take of Calamine, prepared, Yellow wax, of each (onepart, Dub.) half a pound; Olive oil, (two parts, Dub.) one pint. Melt the wax with the oil ; and as foon as the mixture, expofed to the air, begins to thicken, mix with it the calamine, and ftir the cerate until it be cold. These compofitions are formed upon the cerate which Turner ftrongly recommends, in cutaneous ulcerations and excoriations, and which has been ufually diftinguifhed by his name. They ap- Chap. XLI.] Of Liniments, he. 649 pear from experience to be excellent epulotics, and as fuch are frequently made ufe of in praaice. EMPLASTRUM OXIDI FERRI RUBRI ; olim, Emplas- trum Roborans. Edin. Plafter of Red Oxide of Iron, commonly called Strengthening Plafter. Take of Plafter of femivitrified oxide of lead, twentyfour parts ; White refin, fix parts; Yellow wax, Olive oil, each three parts ; Red oxide of iron, eights parts. Grind the red oxide of iron with the oil, and then add it to the other ingredients previoufly melted. This plafter is ufed in weakneffes of the large mufcles, as of the loins ; and its effeas feem to proceed from the artificial me- chanical fupport given to the part, which may alfo be done by any other plafter that adheres with equal firmnefs. 2E TABLES, Shewing the Proportion of Antimony, Opium and Quicksilver, contained in some Compound Medicines. Tartrite of Antimony. Wine of Tartrite of Antimony contains two grains of tartrite of antimony, or tartar emetic, in the ounce. Edin. Opium. Opiate ConfeBion contains one grain of opium in thirty fix grains. Lond. Opiate or Thebaic EleBuary, contains in each drachm about a grain and a half of opium. Edin, EleBuary of Catechu, or Japonic ConfeBion, contains in each ounce about two grains and a half of opium ; for one grain of o- pium is contained in one hundred and ninety three grains. Edin. Compound Powder of Chalk with Opium contains one grain of opium in about fortythree grains. Lond. Compound Powder of Ipecacuan contains one grain of opium in ten grains. Lond. Powder of Ipecacuan and Opium contains fix grains of opium in each drachm, or one grain in ten. Edin. Opiate Powder contains one grain of Opium in ten. Lond. Pills of Opium contain one grain of opium in five. Lond. Opiate or Thebaic Pills contain fix grains of opium in each drachm, or five grains contain half a grain of opium. Edin. TinBure of Opium or Liquid Laudanum is made with two fcru- ples of opium in each ounce of the liquid, or with five grains in each drachm. But a drachm of the tinaure appears, by evapora- tion, to contain about three grains and a half of opium. Edin. Ammoniated TinBure of Opium, or Paragoric Elixir, is made with about eight grains in each ounce ot the liquid, or with about one grain in the drachm. Edin. TinBure of Soap with Opium, formerly called Opiate Liniment, Anodyne Balfam, is made with one fcruple of opium in each ounce of the liquid. Edin. Troches of Liquorice with Opium, contain about one grain of opium in each drachm. Edin. Table, &' Names. Artemisia abfinthium. Rumex acetofa. Acidum acerofum. fulphuricum. aromaticum. Sub Acetis cupri. ./Ether fulphuricus. Sulphuretum hydrargyri nigrum. Boletus igniarius. Potafla. Carbonas fodas. potafTae impurus. ammoniae. Sulphas aluminas. exficcatus. Murias ammoniae. Carbonas ammoniae. Amygdalus communis. Angelica Archangelica. Pimpinella anilum. Sulphuretum antimonii. Oxidum antimonii cum phofphate calcis. Murias antimonii. Tartris antimonii. Aqua carbonatis ammonias. acetitis ammonae. ammoniae. Solutio fulphatis cupri compofita. in the Edinburgh Pharmacopoeia. 659 Names changed, Aqua lixivia cauftica. zinci vitriolati. Arabicum gummi. Argentum nitratum. Arfenicum. Afa fcetida. Aurantium Hifpalenfc. B. Balfamum Canadenfe. Copaibas. Gileadenfe. Peruvianum. Tolutanum. traumaticum. Bardana. Barilla. Barytes. Belladonna. Benzoinum. Biftorta. Borax. Butyrum antimonii. C. Cajepufa. Caiamus aromaticus, Calomelas. Calx viva. Cancrorum lapilli. Cantharis. Cardamomum minus,. Carduus benedidtus. Carica. Carvi. Caryophylla aromatica. rubra. Cafcarilla- Caffia fiftularis. lignea. Catechu. Caufticum commune acerrimum. mitius. lunare. Centaurium minus. CerufTa. acetata. Chamasmelum. Cicuta. Cinnabaris fadtitia. Cinara hortenfis. Cineres clavellati. Cinnamomum. Coccinella. Colocynthis. Netv Names. Aqua pofafHe. Solutio fulphatis zinci. Gummi mimofas nilotica:. Nitras argenti. Oxidum arfenici. Gummi refina ferula: affa: fuetidas. Citrus aurantium. Refina pini balfameae. copaifferas ofticinalis. amyridis Gifeadenfis. Balfamum myroxyli peruiferi. toltiiferas balfami. Tindtura benzoes compofita. Arctium lappa. Carbonas fodas impurus. barytas. Atropa belladonna. Balfamum ftyracis benzoes. Polygonum biftorta. Boras fodas. Murias antimonii. Melaleuca leucadendron. Acorus calamus. Sub Murias hydrargyri; Calx. Carbonas calcis prasparatus. Meloe veficatorius. Amomum repens. Centaurea benedidta. Frudtus ficiis caricae. Carum carvi. Caryophyllus aromaticus. Dianthus caryophyllus* Croton eleutheria* Caffia fiftula. Laurus caffia. Extractum mimofas catechu. Potaffe. cum calce. Nitras argenti. Gentiana centaurium. Oxidum plumbi album. Acetis plumbi. Anthemis nobilis. Conium maculatum. Sulphuretum hydrargyri rubrum. Cinara fcolynnis. Carbonas potalfas impurus. Laurus cinnamomum. Coccus cacti. Cucumis colocynthis, oGO Table oJ Names changed. Confectio japonica. Contrayerva. Cortex peruvianus. Creta alba. Crocus antimonii. *) metallorum. J Cryftalli tartari. Cucumis agreftis. Cupium ammoniacum. vitriolatum. Cynofbatos. D. Daucus filvcftris. Decoctum chamasmeli vel commune. hgnorum. Dens leonis. E. Elaterium. Electuarium lenitivum. Elixir paregoricum. facrum. falutis. ftomachicum. Emplaftrum adhaefivum. cereum. lithargyri nes changed. N. Nafiurtium aquaticurn. Nitrum. Nux mofcha'.a. O. OLri fiillatitia. Oleum fuccini redtificatum. terebinthmas. reetificatuni. Olibanum. Oliva. P. Pal ma. Petroleum Barbadenfe. Petrofelinum. Pilulas cupri. theba'Cae. Pimento niuni. Sulphuretum antimonii pr*cipita- tum. Svrupus toluiferas balfami. papaveris fomniferi. Lcontodon taraxacum. Super Tartris potatl* impurus. pota^sr. Tartris potaffas. Sulphas potaffas. * Tartris antimonii., Refinn pini laricis. Extradtum mimofas catticlm. Tindtura aloe's astherea. lauri cinnamomi compcS ta. muriatis ferri. meloes veficatorii. mimofas catechu. rhei cum gentiana. Vinum aloe's focotorina:. Tindtura toluiferas balfami. Rhus toxicodendron. Gummi afhagali tragacanthx- Menyanthes trifoliata. Trochifci gumr.iofi. 664 Table of Names changed, &e. Names changed. Turpeihufh minerale. Tutia. U. New Names. Sub Sulphas hydrargyri flavus. Oxidum zinci impurum. Unguentum album *vel ceruffae. Unguentum oxidi plumbi albi. aeruglnis. fub Acetitis cupri. coeruleum. hydrargyri. ' citrinum. nitratis hydrargyri. epifpafticum fortius. pulveris meloes vefica< toni. mitius. irifufi meloes veficatorii faturninum. acetitis plumbi. tutiae. <*xidi zinci impuri. Uva paffa. < Frudtus ficcatus vitis viniferi. urfi. Arbutus uva urfi. V. Valeriana fylveftris. Valeriana officinalis. Vinum amarum. Vinum gentiana: compofitum. Vinum antimoniale. Vinum tartritis antimonii. Vitriolum album. Sulphas zinci. coeruleum. cupri. viride. ferri. Vitrum antimonii. Oxidum antimonii cum fulphure vi trificatum. ceratum. antimonii vitrificatum cuir cera. w. Winteranus cortex. Cortex Winterx a romatic. Z. Zincum uftum. Oxidum zinci. vitriolatum. Sulphas zinci. Zingiber. Amomum zingiber. Norn.—(Edin.) In thefe Indexes of changed names, fearing left they might become too long, and fatisfied if every poffible error might be a'- voided, we have only introduced thofe fimples of which we have changed the principal and common names, called in natural hiftory Generic Names ; fuch as Anethum fceniculum for Fceniculum, Aatbemis nobilis for Cham- aemelum, Gentiana Centaureum for Centaurium minus ; but we have o- mitted all thofe fimples whofe former generic names remain, and to which we have only added their fpecific or trivial names, or fuch as Digitalis pur- purea, Rheum palmatum, Papaver* fomniferum. * For the fame reafon, we have thought it fufficient to introduce into thefe Indexes the changed nama of every fimple, having generally omitted the titles of the preparations and compofitions which are formed of them. Thus, we have mentioned, that Laurus Cinnamomum is to be ufed in place of Cinnamomum ; but we have omitted the Aqua, Spiritus, and Tinctura Lauri Cinnamomi, trufting that their new names cannot be a fource of doubt or error to any perfon. ENGLISH INDEX. \ Pag. Page Absorption 74 Alum curd 627 421 Abftraction 70 purified Acetated cerufe 475 water, compound 482 kali 3«5 Alumina 10 vegetable alkali ib. Amalgams 24 quickfilver 455 Amber 311 Acetates 43 prepared 4i5 Acetic acid ib. Ammonia j. 5, iS Acetite of lead 475 prepared 402 of potafs 3 34 Ammoniacal copper 442 of quickfilver 454 iron 450 Acetites 43 Ammoniac, gum 136 Acetous acid 43i 37° Ammoniaret of copper 442 Acetous acid, diftilled 368 Ammoniated alcohol 401 impure 123 oil Sot ftrong 3^9 Amnates 46 Acetous fermentation «3 Amnic acid ib. Acidification 79 Angelica 144 Acids 15 Anguftura "4.5 Aconite 126 Animal oil 517 . Adhefive plafter 640 Anife 276 Adipocere 37 Anodyne liquor of Hoffman 486 ./Ethiops mineral . 472 liniment 5?6 Affinity, laws of 2 Antimonial pills, compound 6x6 Agaric, female 169 powder 43 2 Aggregation, forms of 2 wine 43 *47 foffil, purified 392 calcined by nitre 423 mild 393 Antimony, prepared 415 , 422 vegetable cauftic 378 Apparatus 55 mild 381 Arabic emulfion 5 SO volatile mild 403 Ardent fpirit 483 Alkalies 1°, 375 Aromatic ammoniated alcohol 581 Alkanet 143 electuary, 6ir Alloys 24 confection ib. Almond , 139 powder 600 emulfion, or milk 549 fulphuric ether witl oil 500 alcohol 579 Aloes 133 fulphuric acid ib. Aloetic pills 620 tincture 5^9 wine 5»5 vinegar 554 Alum 312 ArfeW =S > li^ burnt 421 666 English Index. Arfenic acid Arfenious acid 31 Arfeniate of potafs • Arfeniates Arfenite of potafs Arfenites Artichoke Afarabacca Afhcolored powder of quick- filver Affa fcetida Atmofpheric air Attradtion, fpecies of Azotic gas 16 Page 3i 1 156 160 3' J59 3i 2I5 163 4^5 225 n Buckthorn, purging Burdock Burgunday pitch Burgunday pitch plafter, com- pound Page 291 'S3 276 6i4 B. Balauftine Balm Balfam of Canada of Copaivi of Gilead of Peru of Tolu Balfamic fyrup Barberry Barbadoes aloes tar Barilla Barley water Barras Baryta Baytree Bears foot Beaver Beluga Benzoates Benzoic acid Benzoin Birch Bifmuth Biftort Bitter apple Bitter infufion Bitter fweet Bitter wine Bliftering plafter Blue ointment Bole, French Boracic acid Borates Borax Brooklime Broom Bryony 289' 252 276 207 142 262 318 545 167 134 168 177 233 53i 277 12 247 232 182 120 *5 4J"> 37i 310 167 27 *8.S 211 523 306 586 637 643 169 33 ib. 310 322- 307 170 4X5 Caballine aloes Cabbage tree bark ~ Cajeput Calamine cerate • ■• prepared' Calcined antimony magnefia' quickfilver zinc Calomel Caloric Calx of antimony, precipitated of quickfilver, white Camphor liniment, comp. Camphorated acetous acid emulfion or mix- ture liniment oil fpirit Camphorates Camphoric acid Canella Caoutchouc Caraway Carbon Carbonate of ammonia of baryta of iron precipitated of lime prepared of magnefia of potafs pure impure of foda impure of zinc, impure prepared Carbonates 29 Carbonic acid gas oxide gas Carbonous oxide *34 228 25i 3*S 648 480 427 40S 467, 479 459 4- 43i 464. 38, 245 58d 555 5 50 5S0 503 562 45 ib. r73 40 179' • 18 400 175 445 446 176 4i5 419 3»o. 381 176 39a 177 325 480 174 374 29 20 it. English Index. 667 Carbonous oxide Carburetted hydrogen Cardamom, leffer Carr»t, wild Cafcarilla Caffia bark tree water Caftor 20 34 139 317 210 244 180 509 182 oil 295, 500 Cataplafms 627 ©f allum ib. of cumin • ib. of muftard 628 Catechu 255 Cauftic, common, ftrongeft 378 milder 380 lunar 438 Caviare 125 Cayenne pepper 173 Centaury, fmaller 188 Cerated glafs of antimony 425 Cerate of acetated litharge compound 643 of cantharides 636 of impure carbonate of zinc 648 of foap 641 of fpermaceti . 631 of yellow refin 632 fimple 631 Cerufe 383 Chamomile 145 Chalk i7 74 Citrates 44 Citric acid '*" Uu Page. Clarification SS Claffification of fimple fubftances 3 Clove gillyflower 218 Clove tree 221 Coagulation 71 Cobalt 27 Cochineal 200 Cohobation 70 Collection of fimples 47 Colomba 203 Colophony 378 Coloquintida 311 Coloring fermentation 83 Colts foot 320 Columbates 32 Columbic acid 31 Columbium 28 Combination jl Combuftion 15, 7* Compounds, primary and fecon- dary 4 Concentration 65 Condenfation ib. Confections 610 Congelation 71 Conferve of arum 609 of orange peel 60& of hips ib. of rofe buds ib. of fea wormwood ib. of floes 609 of fquills 610 of w ood forrel 608 Contrayerva 220 Copper 35, 313 Copperas 224 Coral, red 239 prepared 415 Coriander 20S Cork 40 Cowitch 220 Crab *7a Crab's claws ib. prepared 415 eyes 17 2 prepared 415 ftones *72> 4'5 Craw fifh * 7* Cream of tartar 3 '4 Creffes, water 3°J Crocus of antimony 423 Crucibles 6a Cryftallization 76 Cryftals of tartar 3'4 Cubebs 2S t 668 English Index. 53 74 53i Cucumber, wild Cumin plafter Currant, black red Damfon, bitter Dandelion Decantation Decodtion of barley compound ib. of cabbage tree bark 530 of chamomile 528 of elm 533 of guaiacum, com- pound ^30 of hartfhorn 553 of hellebore, white 531 of marftimallows 527 of mezereon 530 of Peruvian bark 529 of farfaparilla 532 com- pound 533 of feneka 532 Decoction for fomentation 528 for glyflers ib. Decompofition 74 Decrepitation 65 Deflagration 79 Deliquefcence 73 Dephlcgmation 70 Defpumation ' 53 Digeftion 74 Dill 143 water 509 Difoxygenizement 81 Diffalution 75 Diftillation 66 Diuretic fait 38^ Dover's powder 603 Dragon's blood 288 Drying of herbs and flowers 491 rage. 256 Egg 212 mells, prepared 634 Elaterium 295 Elder, common ib. rob ointment Elecampane Electricity 289 2AS Electuary of caffia of catechu Earthern ware Earths Edulcoration Effervefcence Efflorefcence 13 10 73 75 73 Page. 27$ 416 497 301 497 635 238 8 612* 613 compound 614 of opium 615 of fcammony 614 of fenna 613 Elemi 141 Eleutheria 21 o Elixer of healrh 563 Elm 3*° Elutriation 45 Emulfions 549 Emulfion, almond ib. Arabic ib. camphorated 550 of afla fcetida 551 of gum ammoniac ib. Epifpaftie ointment, mild 635 ftronger 636 Epfom fait Jij Epulotic cerate 648 Erygno 221 Ether 35, 484 Evaporation 64 Expreffion 54 Exficcation 65 of fimples 47 Extract of aloes 592 of black hellebore 59 r of broom tops 592 of cafcarilla, refinous 595 of chamomile 592 of cinchona 593 of coloquintida, com- pound 596 of gentian 591 ofjalap 593 of lead 477 of liquorice 229, 591 of logwood 592 of oak bark ib. of opium 594 of Peruvian bark 593 of Peruvian bark, hard ib. of Peruvian bark, foft ib. of Peruvian bark with the refin 59$ English Index. 669 Page. Extract of red Peruvian bark, refinous 595 of rue 59i of favin 592 of fenna 591 of white poppy 592 of wild valerian, refin- ous 596 Extraction 73 Extradtive 40 F. Fat 36 > 3»5 Fennel, fweet 144 water 5°9 Fenugreek 319 Fermentation 82 Fern, male **S Fibrine 4* Fig 226 Filtration 53 Fir hemlock 276 Scotch 277 fpruce 276 Fixed oils 35 .499 Flax, common 249 purging ib. Flowers 319 of benzoin 371 of fulphur, wafhed 359 of zinc 479 Fluates 32 Fluoric acid gas ib. Fowl 275 Foxglove 218 Frankincenfe, common 276 Fuel 59 Fumitory, common 227 Furnaces 60 Fufion 61 G. Gadolina 11 Galbanum J7° Galipot 277 Gallates 44 Gallic acid lb- Galls 39* Galvanifm 9 Gamboge 308 Garlic x3« Gafeous oxide of carbon 20 Gelatine 40 fcfr * Gentian German leopard's bane Germander, water Ginger Ginfeng Glafs of antimony Glauber's fait Glucina Gold Golden root Goofe fat Granulation Grapes Groats Guaiac Gum ammoniac, purified Arabic plafter refins, properties of tragacanth troches H. Hartfhorn burnt Heat Hellebore, black white Hemlock Hepatic aloes Hepatized ammonia Henbane black Hips Hog Hogs lardj prepared Honey acetated Honey, clarified of rofes of fquills Horehound, white Horfe chefnut radifh Hydro carbonates Hydrogen Hydroguret of nitrogen Hydroguretted phofphorous fulphur Hydrofulphuret of ammonia Hyp«roxygenized muriates muriatic acid Hyffbp hedge Page. 227 154 3i* 238 269 424 396 11 24 307 i43 5a 322 166 230 39 59* 25* 640 242s 164 618 iSS 418: 59 232 32E 204 134 410 236 297 629 25* 546 ib. 547 548 250 128 202 34 *7 18 23 2r 409 32 ib. 238 229 670' English Indexi Page. Kino tsgi. 24* Incombuftible coal 20 Inflammation i\5, 78 infufion 74 Infufions 522 ofcatechu 524 of cinchona 522 of foxglove 523 of gentian, com- pound ib. of Peruvian bark 522 of rhubarb 524 of rofes 525 of fenna fimple 526 tartarized ib. of tamarinds with fen- na ib. Infpiffation 65 Ipecacuan 184 Iron 2j, 222 filings 223 purified 444 fcales of 224 purified 444 Ironatedwine' 452 Ifinglas 125 J. jalap Japonic confection infufion Jelly Juice of blackcurrant infpif- fated of deadly nightfhade, in- fpiffated of elder, infpiffated of hemlock, infpiffated of henbane infpiffated of lemon, infpiffated of poifonous lettuce, infpif- fated of fcurvygrafs, compound of wild cucumber, com- pound of wolfsbane Juniper K. Kali, pure prepared Kermes mineral 2p6 614 524 39 496 ib. ib. ib. ib. ib. ib. 495 497 4V6 340 378 380 426 26, 28 L. Laccate*s Laccic acid Lactates Ladtic acid Ladanum plafler, compound Ladies fmock Larch Lard Laudanum Laurel Lavender Lead Lemon Lemon peel water Lenitive electuary Leopards bane, German Lettuce, wild Levigation Ley, cauftic mild Light Lignin Lily, white Lime 11 water with pure kali Liniment of ammonia ftronger fimple Linfeed' oil with lime Liquefaction Liquid Laudanum Liquor of acetated volatile alkali 40 of ammoniated cop- per of cauftic volatile alkali of mildeft vegetable alkali of mild volalile alkali liquor, volatile, df hartfhorn Liquorice Litharge plafter with refin Litharge plafter with quick- filver Liver of fulphur Lixiviation Logwood 45 ib. 44 ib. 197 634 179 276 3»5 573 247 248 2 199 509 613 154 243 5 * 375 383 6 46 248 171 4>3 380 5°r ib. 629 249 500 502, 6a 57 443 399 383 405 ib. 228 284 639 640 645' 3«9 73 231 English Index. Lobelia Lunar cauftic Lutes Page. 249 438 57 M. Mace 261 Maceration 74 Mackaw tree 202 Madder 297 Manganefe 27 Magnefia ?i, 418 alba 419 calcined ib. Magnet ifm 9 Mahogany 316 Malic acid 44 Malates ib. Manna 226 Marjoram, fweet *68 wild ib. Marfh mallow 136 Marfh trefoil 354 Martial flowers 45° Maftich 282 Syrian herb 3'7 Meafures 5° Mechanical operations of phar- macy 49 Mercurial ointment, milder 644 ftroBger ib. pills ^ 623 Mercury 26, 233 Metals 22 Mezereon 216 Millipeds, prepared 493 Molaffes 299 Molybdates 31 Molybdenum 28 Molybdic acid 31 Monks hood 126 Mucilage of gum Arabic 533 tragacanth 531 of quince feeds 536 of ftarch 534 Mucites 45 Mucous acid 44 Mulberry 257 Muriate 258 Muriates 32 Muriate of ammonia 359 and iron 450 of antimony 430 ofbaryta 410 of quickfilver 457 Of foda 260 fcr 3 671 Page. 39* 457 462 Muriate, dried Muriated quickfilver, corro- five mild quickfilver mild, pre- cipitated *b. quickfilver, mild, fub- li mated 459 Muriatic acid 366 gas 32 Mufk 257 mixture 55a Muftard cataplafm «2 8 common 3°4 white 3°3 Mutton fuet 269 prepared ^29 Myrrh 263 N. Natron prepared Nettle Nickel Nightfhade, deadly .Nitrates Nitrate of potafs of filver Nitrated, quickfilver, red filver Nitre purified Nitric acid oxide gas Nitrous acid diluted oxide gas Nitrites Nitrogen Nutmeg Oak Oats , Oil of almond of amber rectified of anife of cajeput of caraway of caftor of fennel feeds flowers 393 3.20 27 164 29 265 266, 387 438 469 43* 366 387 29> 36S 17 29> 362 3^3 17 29 16 261 290 166 500 372 5i6 jn. 251 5" 500 5'i ib. 672 English Index. Page. Oil of hartfhorn 405 rectified 517 of juniper berries 511 of lavender ib. of linfeed 349, 50b of muftard ib. of mace 262 of olives 267 of origanum 511 of pennyroyal ib, of peppermint ib. of petroleum 516 of pimento 511 of rofemary ib. of rue ib* of faffafras ib. of favin ib. of fpearmint ib. of turpentine ib. rectified 512 of turpentine 276 of vitriol 124 of wine 486 Oils fixed 35 volatile 37 Oily ethereal liquor 486 Ointment of acetated cerufe 643 of acetite of lead ib. of elemi, compound 633 of grey oxide of quick- filver 644 of hogs lard 630 of impure oxide of zinc 648 of infufion of cantha- rides 635 of nitrate of quickfil- ver 646 of nitrate of quickfilver milder 647 of nitrous acid 638 of oxide of zinc 648 of powder of Spanifh flies , 636 ofq ickfilver 643 of red oxide of quick- filver 646 of Spanifh flies 635 of fpermaceti 630 of fub acetite of cop- per 647 of tar 633 of tutty 648 of wax 630 of white calx of quick- filver 646 of white hellebore 638 of white oxide of lead 642 Ointment of yellow refin 631 fimple 1 630 Ointment, white 642 Olibanum 24t Olive 267 Onion 135 Opiate electuary 615 powder 604 Opium 270 pills 625 purified 596 Opoponax 274 Orange 197 peel water 5*8 Orris Florentine 239 Oxalic acid 43 Oxalates ib. Oxides 15 Oxide of antimony, with phof- . phate of lime 433 of antimony, with ful- phur, by nitrate of potafs 423 of arfenic 156 of iron, black, purifi- ed 444 red 448 of lead, white 283 r«d ib. femivitrified 284 of quickfilver, afh color- ed 465 of quickfilver, red by ni- tric acid 468 of fulphur ii of zinc 478 impure 325 prepared 480 Oxidizement 79 Oxygen X4 Oxygenized muriates 32 muriatic acid 367 muriatic acid gas 32 0#ygenizement ' 14, 78 Oxymel fimple 346 Oyfter 268 Oyfter fhells p repared 415 Palm oil 202 Panary fermentation 83 Paregoric elixer 573,584 Pareira brava 196 Parfley 152 Pearl afhes 176 English Index. 673 Pearl Barley Pellitory of the wall Peppermint water Pennyroyal water Pepper, black Cayenne Jamaica long Peruvian bark Pharmaceutical operations Pharmacy, elemenu of Phofphates Phofphate of lime of foda Phofphites Phofphoric acid Phofphorous acid Phofphorous Phofphurets Phofphuretted nitrogen gas Pills of aloes compound with affa fcetida with colocynth with myrrh of ammoniaret of cop- per of affa fcetida compound of galbanum, compound Pills of opium of rhubarb, compound Pimento water Pink, Carolina Plafters 37 Plafter of affa fcetida of burgundy pitch, com- pound of frankincenfe, com- .,_ pound '"" of gum ammoniac, with quickfilver of litharge, compound of quickfilver of red oxide of iron of femivitrified oxide of lead of foap of Spanifh flies compound common funple or wax Plates, explanation of Page. 233 146 274 254 5C9 254 509 281 173 264 281 189 47 1 3* 418 394 30 /*. ib. ■21 22 ib. 620 621 ib. ib. 622 623 622 623 625 ib. 264 509 3°7 , 628 640 634 642 645 641 645 649 639 641 637 ib. 639 632 no Page. Platinum 24 Plumb 287 Plumbago 20, 26 Plummer's pills 626 Pneumatic apparatus 69 Poifon, oak 294 Polypody 285 Pomegranate 289 Poppy,red 270 white ib. Porcelain 13 Potafs 378 with lime 380 Potafhes 176 Powder of aloes with ca- nella with guaiac with iron of afarabacca, compound 601 Powder of carbonate of lime compound of chalk, compound with opium, compound of crabs claws, com- pound of ceruffe, compound of contrayerva, com- pound of ipecacuan, with opium compound of jalap, compound of myrrh, compound of fcammony, compound with aloes with calomel of fenna, compound of fulphate of alumina, compound of tin of tragacanth, compound 606 Precipitation 75 Prefervation of. fimples 47 Prooffpirit 13° Prunes 3S7 Pruffiates 46 Pruffic ib. Pulps, extraction of 498 Pulverization 51 5°7 600 ib. 601 602 ib. ib. 603 ib. ib. 604 ib. ib. 605 ib. 606 ib. 477 0_ Quaffia Quickiime 290 171 674 English Index. Quickfilver Qmnce purified with chalk with fulpher R Page. 233 453 467 472 389 Raifins 343 Rafpberry 298 Ratilefnake root 284 Receiver 68 Redtification 70 Redudlion Si Repulfion, fpecies of 2 Refin 280 Refins Zl, 588 Refinous ointment 632 • ...; plafter 640 Retorts 67 Rhododendron 294 Rhubarb 292 wine 587 Rock oil 1'6 8 Rofe, damafk 296 dog .. 297 red 396 water 5°9 Rofemary 297 Rofin, white 277 yellow 27s, 597 Rue 298 Ruft of iron 445 S Saccharine fermentation 12 Sacred tindture 5*5 elixer 574 Saffron common or Engl fh 209 meadow ' 203 Sagapenum 300 Sage 301 St. John's wort, common 238 Sal ammoniac 259 polychreft 3»9 Salifiable bafes , 9 Salt of amber 3.73 purified ib. of benzoin 37i of hanfhorn 405 of fteel 447 of tartar 38i Saponaceous liniment 575 plafter 642 Sapphire water Sarcocolla Sarfaparilla Saffafras Saturnine ointment Saunders wood, red Savin < Scammony Scurvygrafs, garden Sea fait dried Sebaccic acid Sebates Seneka Senna Septfoil Serruga Sheep Sifting Silica Silver 24, Simple fubftances, claflifica- tion of Simarouba Sinapifm Skerrit creeping Slaters Sloe Snakeroot Virginian Snakeweed Soap Soaps Soap liniment, compound Socotorine aloes Soda carbonate of Soluble tartar Solution of acetite of zinc of muriate of ba- ryta of muriate of lime of fulphate of zinc of fulphate of cop- per, compound Sorrel wood Soot of wood Southern wood Spanifh fly Spar, ponderous Spearmint water Specific gravity Spermaceti 36, Spirit of ammonia rage '443 3°3 306 247 643 288 241 205 201 260 396 46 '**. 284 181 3i8 "5 369 52 jo 153 3 62s 335 367 287 153 285 302 37 576 .12 177 39* 72 483 412 4'7 482 441 298 269 227 160 252 3»3 254 5°9 5° , 275 4OJ Englih Index. 675 Page. Pagr. Spirit aromatic 58i Sub nitrate of quickfilver 469 fetid 521 Sub fulphate of quickfilver, fuccinated 582 yellow 470 of anifeed, compound 52P Suber 40 of caraway 5*8\ Suberates 4S of cinnamon 5'9 Suberic acid ib. of horfcradifh, compoun d52i Sublimation 71 of Juniper,, compound 520 Succinates 45 of lavender 5i9 Succinic acid 45 ,372 compound 57° Suet 269 of mindererus 408 Sugar 38 ,299 of nitrous ether 489 cane 299 of nutmeg 5»9 double refined ib. of pennyroyal ib. raw ib. of peppermint ib. of lead 475 of pimento ib. Sulphate 3C >3rI of rofemary 520 of alumina, dried 421 of fpearmint 5'9 of baryta 313 of vitriolic ether 485 of copper 315 compound 486 of iron 224 447 of Volatile alkali 401 dried 448 i. i aromatic 581 of magnefia 3'3 fetid 521 of potafs 387 of wine 130 with ful- rectified 128 phur 3«9 Spirits, diftilled '■■■'■ 5i8 of foda 396 Sponge 307 of zinc 325, 481 burnt 493 Sulphites 3«> Spontaneous evaporation 73 Sulphur 30 Spurge laurel , 216 of antimony, preci- Squill 303 pitated 427 i ; dried 49 2 ointment 638 prepared ib. precipitated 360 pills 625 fublimed 3U vinegar 555 fublimed, wafhed 359 Starch 58,319 Sulphurated kali 39° Starch, wheat i4r oil 5°3 Stavefacre 217 petroleum ib. Steel 25 vegetable al- Sterlet 125 kali 39° Still 67 quickfilver, Stomachic elixer 567 black 47 2 Storax 3»o red 473 purified 598 Sulphurets 21 Sturgeon *25 Sulphuret of antimony 147 Strengthening plafter 646 precipi- Strontia 12 tated 427 Styptic powder 606 prepar- water 441 ed 4:2 Sub acetite of copper 2'3 of iron 4c 9 Sub borate of Soda 310 of potafs 3§9 Sub muriate of quickfilver 459 of quickfilver, precipi - black 47 ^ tated 461 Sulphuretted nitrogen gas 21 of quickfilver hydrogen gas ib. 676 English Index. Page. Sulphuretted phofphorus 22 Sulphuric acid 30,124 diluted 361 ether 484 - with alcohol 485 Sulphurous acid gas 29 Super fulphate of alumina and potafs 312 Super tartrite of potafs 314 Sweet flag 127 Swietenia, febrifuge 316 Syrup of acetous acid 539 of balfam of Tolu 545 of black currants 540 of buckthorn 543 of clove July flowers 546 of colchicum ib. of garlic 537 of ginger 538 of lemon juice 530 ofmannt 541 of marfhmallows 537 of mulberries 539 of opium 542 of orange peel 538 of poppies, red 543 white 542 of rafpberries 339 of rofes, pale 544 red ib. of faffron 541 of fquills 544 of Tolu 545 of vinegar ib. of violets ib. fimple 537 T. Table of the preparations of an- timony 149 the preparations of mercury 234 the fpecific gravity of mixtures of alco- hol and water 1-1 Tallow 36 Tamarind 316 Tannin 29 Tanfy 317 Tar 2S0, 476 Tar ointment 633 Tartar 3*5 emetic 433 Tartarized iron 451 kali 391 vegetable alkali ib. Tartarous acid 43 Bag«. Tartrites 44 Tartrite of antimony 433 of potafs 39i Tellurium 26 Temperature 4 Thebaic eledtuary 6i5 pills 625 tincture 573 Thiftle, blefled 183 Thorn apple 217 Tin 26, 309 Tincture of acetated iron 45 2 of aloes 558 ethereal 57» compound 559 with myrrh 558 of ammoniacal iron 451 of affa fcetida 560 of balfam of Peru 561 of balfam of Tolu 577 of benzoin, compound 56 \ of black hellebore 567 of camphor 362 of cantharides 571 of cardamom 559 compound ib. of cafcarilla 562 of caftor 563 compound 582 of catechu 571 ofcinchona 564 compound ib. ammoni- ated 583 of cirfnamon 569 compound 569 of colomba 565 of foxglove 566 of galbanum ib. of ginger 578 of gentian, compound 567 of guaiac 567 of guaiac, ammoniat- ed, or volatile 583 guaiac ib. of henbane 568 ofjalap 565 of kino « 568 of lavender, com- pound 570 of muriate of iron 449 of mufk 572 of myrrh ib. of opium 573 camphorated ib. ammoniated 584. English Index. m Page. Tincture of orange peel 561 of Peruvian bark 564 compound ib. of rhubarb 574 bitter 575 compound 574 of rhubarb with aloes 574 gentian 575 of rofes 574 of faffron 566 of favin, compound 575 of fenna 563 offnake root 560 offoap 575 with opium 576 of focotrine aloes 557 of Spanifh flies 571 of fquills 576 ofTolu 577 of valerian ib. of valerian, ammon- iated 5§4 of white hellebere 577 Titanium ' i 27 Tobacco 264 Tobacco wine $%T Toxicodendron 294 Trituration 52 Troches of carbonate of lime 616 of chalk ib. of liquorice ib. compound 617 * with opium ib. of ftarch 618 of magnefia ib. of nitrate of potafs 619 of nitre ib- of fulphur ib. Tungftates 3r Tungftein 28 Tungfticacid 31 Turmeric 2I5 Turpentines 277, 279 Turpeth mineral 47° Tutty, prepared 4'5> 480 U. Uranium Urates Urea Uric acid Uftulatipn Valerian, wild 27 46 4a 46 63 321 Vaporization Verdigris Verdegris, prepared Veffels Vine Vine, wild Vinegar diflilled medicated Page. 63 213 4i5>44i 55 322 170 x23 368 553 aromatic 554 of meadow faffron ib. of fquills ' ib. Vinous fermentation 82 Violet, March 322 Vitrification 62 Vitrified antimony 424 Vitrified oxide of antimony with fulphur 424 with wax 425 Vitriol, blue 335. green ib. white ib. Vitriolated foflil alkali 397 iron 447 kali 388 natron 397 quickfilver 470 tartar 387 vegetable alkali 388 zinc 481 Vitriolic acid 124 diluted 36* ether 485 ethereal liquor 486 Volatile liniment 501,581 oils 37, 510 empyreumatic 515 W. Wake robin Walnut Water Water, diftilled flag of acetated ammonia 162 240 18 563 239 408 litharge 477 compound ib. of acetite of ammonia 408 of aerated iron 446 ofammonia 39S of ammonia 404 of ammoniated copper 443 of carbonate ofammonia 404 of cauftic ammonia 398 of fixed air 374 ✓ 678 English Index. Page. Page Water, of potafs 375 Wine of rhubarb 5«7 of prepared kali 383 of focotorine aloes 5»5 of pure ammonia 399 of tartarized antimony 43 6 of pure kali 375 of tartrite of antimony ib. of fuper carbonate of of tobacco 5»7 potafs 383 Winter's bark 324 of fuper carbonate, of Wolfsbane 126 foda 394 Wood 40 of vitriolated zinc with Wood forrel 269 camphor 842 Worm feed 161 Watery fufion 65 Wormwood, common i6z Wax 36 fea i6t ointment 630 Woulfe's apparatus «9 plafter 632 yellow 187 Y. white ib. Weights 49 Yttria *i Wheat 3,19 Whortleberry 152 Zi Willow, crack 300 Wine 322 Zedoary, long 138 of aloes 5*5 round 241 of antimoniated tartar 43<5 Zinc 3=4 of antimony ib. Zirconia 10 of gentian, compound of ipecacuan 586 Zoonates ^ 46 ib. Zoenic acid ib. of iron 452 LATIN INDEX. A. Page. Page A BROTANUM 160 Adiantum cajiillus veneris 32$ Abfinthium maritimum 161 ■/Erugo 213 ponticum 329 praeparata 44r vulgare 162 /Efculus hippocaftanum 12S Acetofa pratenfis 298 ./Ether fulphuricus 4S4 Acetofella 269 vitriolicus 485 Acetis hydrargyri 454 fulphuricus cum alco- plumbi 475 hole 48S potaffae 384 aromaticus 579 Acetum *23 ^Ethiops mineralis 47* aromaticum 554 Agaricus albus 329 deftillatum 368 chirurgorum 169 > 329 colchici 554 mufcarius 32S fcillae maritimat ib. Aggregatae 355 fcilliticum 555 Agrimonia eupatoria 32S Achillea millefolium 328 Alcea rofea ib. nobilis ib. Alcohol 128 »483 ptarmica ib. ammoniatum 40 L Acidum acetofum 370 aromaticum 5«r camphoratum 553 fcetidum 52* diftillatum 368 dilutum 130 forte 369 Algae 357 impurum 123 Alkali foflile mite 393 benzoicum 37i foflile vitriolatum 397 caibonicum 374 vegetabile acetatum 3&S muriaticum 366 caufticum 37« nitricum 363 mite 38r nitrofum 362 fulphuratum 39° dilutum 3*53 tartarifatum 39* fuccini 372 vitriolatum 388 fulphuricum 124 volatile mite 403 aromaticum 579 Allium cepa »33 dilutum 361 fativum »3i Acidum vitriolicum 124 Alnus 329 dilutum 361 Aloe perfoliata 133 Acipenfer fturio, &c. 125 Althaea officinalis 130 Aconitum napellus 126 Alumen 3'2 neomontanum ib. purificatum 421 Acorus calamus 137 uftum ib. Adeps anferinus 143 Ambra giyfea 32S ovis arietis 369 Amentaceae 354 fuis ferofae 315 Ammonia praeparata 402 fuillus ib. Ammoniaretum cupri 442 prajparatus 629 Amomum cardamomum *39 680 Latin Index. Page. Page, Amomum grana paradifi 328 Aqua compofita 477 repens U9 menthae piperita; 509 zedoaria 138 pulegii 509 z.ngiber ib. . fativae ib. Ammoniacum 136 myrti pimentae " 5°9 purificatum 598 pimento ' ib. Amygdalae '39 potaffae 375 Amygdalus communis ib. pulegii 5°9 nana 328 rolae centifoliae ib. Amylum 141 fappharina 443 Amyris elemifera ib. flyptica 441 Zeylanica 142 fuper carbonatis potaffae 383 Gileadenfis ib. fuper carbonatis fodae 394 Anagallis arvenfis 320 zinci vitriolati cumcam- Anas anfer *43 phora 482 Anemone nemorofa 329 Aquifolium 342 pratenfis ib. Arbutus uva urfi *52 Anethum graveolens 143 Arctium lappa r53 fceniculum ih. Argentum ib. Angelica archangelica 144 nitratum 438 Anguftura 145 Ariftolochia clemaritis' 329 Anifum 276 r«tunda if. ftellaturh 342 ferpentaria r53 Anthemis nobilis 145 trilobata 329 pyrethrum 146 vulgaris ib. Antimonium 147" Arnica montahsi *54 calcinatum 437 Arfenicum *5« muriatum 430 Artemifia abrotanum 160 praeparatum 422 abfinthium 162 tartarifatum 433 maritima 161 vitrificatum 424 pontica 329 Antirrhinum linaria 329 fantonica 161 Apis mellifica 187 Arum maculatum 162 Apium petrofelinum 152 Affa fcetida 225 Aquaaeris fixi 374 Afarum Europaeum 163 acetitis ammoniae 408 Afcyroideae 35* aluminis compofita 482 Afperifoliac 355 Ammoniae 398 » 404 Afphaltum 168 acetarae 408 Aflragajus exfeapus 329 caufticae 398 tragacantha 164 purae 399 Atropa belladonna ib. anethi 509 Aurantium Hilpalenfe 197 calcis 4i3 Avena fativa 166 carbonatis ammoniae 404 Aves ^ 349 cinnamomi 5°9 citri aurantii 508 B. medicae 5P9 cupri ammoniati 443 Balauftia 289 ■ deftillata 508 Balfamum Canadenfe 276 ferri aerati 44« Copaiva 307 fceniculi dulcis 5°9 Gileadenfe 142 kali pracparati 383 Peruvianum 262 puri 375 myroxyli Peruiferi 262 lauri caffiae 5°9 ftyracis benzoini 310 cinnamomi ib. officinalis ib. lithargyri acetati 477 Toluifcrse balfami 318 Latin Index. 681 Tolutanum traumaticum Bardana Barilla Beccabunga Belladonna Bellis perennia Benzoinum Berberis vulgaris Betula alba alnus Bicornes Biftorta Bitumen petroleum Boletus igniarius laricis Bolus armena alba Gallicus Boras fodae Borax Bos taurus Botrys vulgaris Braffica eruca Bryonia albat Bubon galbanum C. Cacao Cajeputa Calamariae Calamus aromaticus Calculi cancrorum Calendula officinalis Calomelas Calx cum kali puro hydrargyri alba ftibii praecipitata viva zinci Calycanthemae Campanaceas Camphora Cancer aftacus pagurus Canella alba Cannabis fativa Cantharides Capillus veneris Capficum annuum Carbonas ammoniae barytae calcis praeparatus Page. 3»8 56i lS3 in 322 164 329 310 167 ib. 329 355 285 167 169 329 ib. ib. 169 310 ib. 340 ib. ib. 170 ib. 348 25» 357 127 172 340 459 380 464 43i 171 479 35* 355 247 172 ib. 173 340 252 328 173 174 402 175 176 415 Carbonas ferri praecipitatus magnetise potaffae impurus puriffifnus fodae impuruS zinci impurus praeparatus Cardamine pratenfis Cardamomum minus Carduus benedidtus Marianus tomentofus Carex arenaria Carica Carpobalfamum Carum carui Carui CaryophyJla aromatica1 Caryophyllas Caryophyllata Caryophyllum rubrum Cafcarilla Caffia fiftula fenna Caftor fiber Caftoreum Cataplafma aluminis cumini finapeos Catechu Caufticum commune acerrimum 378 Page. 445 446 419. 380 176 38r 392 177 325 48Q '79 *39 183 340 344 34<> 226 142 I79 ;*. 22 1 35* 342 2lg 2IO 244 180 I8£ ib. ib. 627 ib. 628 255 minus lunare mitius Centaurea benedidta Centaureum minus Cepa Cephaelis ipecacuanha Cera flava alba Cerafus Ceratonia filiqua Ceratum cantharidis 380 438 380 *«3 18S 133 184 187 ib. 346 340 636 carbonatis zinci impuri 648 epuloticum tb. lapidis calaminaris ib. lithargyri acetati com- pofitum 643 refinae flavas 632 faponis 641 fimplex 631 fpermatis ceti ib. 682 Latin Index?. Page. Pag?. Cerefolium 347 Conferva rofae 609 CerufTa 283 caninae 608 acetata 475 rubrae ib. Cervus elaphus 188 fcillx 610 Chamaedrys 348 Contort re 355 Chamaemelum 145 Contrayerva 220 Chamaepitys 348 Convolvulus Americanus 341 Chamomilla vulgaris 344 jalapa 206 Chela? cancrorum 172 fcammonia 205 praeparatae 416 Copaifera officinalis 207 Chelidonium majus 340 Corallium rubrum 239 Chenopodium ambrefioides ib. Coriandrum fativum 208 botrys ib. Cornu cervi . 188 Chinai 347 cervinum uflum 418 Chironia centaurium 188 Cortex angufturae 145 Cichoreum intybus 34° Peruviauus 189 Cicuta 204 Cremor tartari 3'4 Cinara hofenfis V-S Crocus antimonii 423 Cinchona Caribaea *95 fativus, 209 officinalis 189 Croton eleutheria 21O Cineres clavellati 176 Creta 176 Cinnabaris factitia 473 praeparata 4*5 Cinnamomum 344 Cruftacea 350 Cilfampelos pareira 196 Cryptogamia 354 Ciftus Creticus lb. Cryftal'.i tartari 3H Citrus aurantium 197 Cubeba 281 medica 199 Cucumis agreftis 256 Clematis erecta 341 colocynthis 211 Coadunat;e 35S melo 34i Coagulum aluminofum 627 Cucurbita pepo ib. Coccinella 200 Cucurbitaceae 355 Coccus cacti ib. Cuminum cyminum 212 Cochlearia armoracia 202 Cuprum ib. officinalis 201 ammoniacum 442 Cocos butyracea 202 ammoniatum ib. Colchicum autumnale 203 vitriolatum 214 Colocynthis 2ir Curcuma longa 2*5 Colomba 203 Cycas circinalis 341 Columniferas 356 Cydonia malus 289 Compofita: 3 54 Cymofae 355 Confedtio aromatica 611 Cynara fcolymus 2I5 Japonica 613 Cyniphis nidus 291 opiata 6i5 Cynomorium csccineum 34i Conferva dichotoma 34i Cynofbatus 297 Conglomerates 355 Cytinus hypociftis 34* Coniferae 354 Conium maculatum 204 D. Conferva abtinthii maritimi 608 acetofellae 609 Daphne mezereum 216 ari ib. Datura ftramonium 217 citri aurantii 608 Daucus carota ib. corticis exterioris au- fylveftris 217 rantii Hifpalenfis ib. Decandria 352 cynofbati ib. Decoctum althaex officinalis 527 lujulas ib. anthemidis nobilis 528 pruni fylveftris 609 chamsemeli ib. Latin Index. (3cV3 Becodtum cinchonae officinalis 359 commune 258 cornu cervi 553 corticis Peruviani 259 daphnes mezerei 510 Geoffraeae ineruais ib. guaiaci officinalis, com- pofitum i&m hellebori albi 531 hordei diftichi • ib. compofitum ib.. lignorum 530 polygalae fenegae 533 pro enetnate, 528 pro fomento ib. farfaparillae 532 compofi- tum 533 fmilacis farfaparillae 53 a ' . ulmi 533 Delphinium ftaphifagria 217 Diadelphia 353 piandria 350 gianthus caryophyllus 218 ictamnus albus 341 Creticus 345 Didynamia 352 Piervilla . 343 Digitalis purpurea 318 Dicecia 354 podecandria 352 Dolichos pruriens 220 Dorftenia contrayerva ib. Dulcamara 306 Dumofae 356 £. Ebulus 347 Elaterium 256, 497 Electuarium aromaticum 611 cafliae fiftulae 612 fijnnae 613 catechu ib. compofitum 614 lenitivuiri 613 opiatum 615 fcammonii 614 Thebaicum 615 Elixir paregoricum 573>584 facrum 574 falutis 563 ftomachicum 567 fcmplaftrumadhaefivum 640 ammoniaci cum hy- drargyro 4<\s W \r Pag?- Emplaftrura antihyftericum 646 affae foetidas ib. caniharidis 637 cerae 632 compofitum ib. cereum 632, commune 639 cumini 634 gummofum 640 hydrargyri 645: ladani compofitum 634 lithargyri 639 lithargyri compofi - turn 641 lithargyri cum hy- drargyro 64S lithargyri cum re- fina 640 meloes veficatorii 637 meloes veficatorii compofitum ib. oxidi ferri rubri 649 oxidi plumbi femi- vitrei 639 picis Burgundicae 634 picis compofitum 634 refinofum 640 roborans 649 faponis 641; fimplex 632 thuris compofitum 64ai veficatorium 637 Emulfio amygdalis communis 549. Arabica ib. camphorata 550 Enneandria 35a Enfatae 35* Enula campaoa 238 Epidendrum vanilla 34^ Eruca 340 Eryngium maritimum 22c Eryfimum officinale 34* Eugenia caryophyllata 22t Euphorbia officinalis 34t Exficcatio herbarum et florum 49^ Extractum^ aloes 59* ar.themidis nobilis ib. cafcarillae 595 cafllae fennae 59c chamaemeli 592 cinchonae 593 cinchoua: officinalis 594 colocynthidis com- pofitum' 596 cdnvolvuli jalapae 595 eorticis Peruviani 593 684 Latin Index'* Page. G. Extractum corticis Peruviani , durum 593 Gadus lota 34: corticis Peruviani Galanga 344 molle lb. Galbanum 170 corticis Peruviani Gallae 291 cum refina 595 Gambogia 301 corticis Peruviani Genifta 3©7 rubri refinofum ib. Gentiana 227 geniftae 592 centaureum 188 gentianae luteae 59i pannonica 342 glycyrrhizoe glabrae 229 Geoffraca inermis 228 haematoxyli Campe Geum paluftre 342 chenfis 592 rivale ib. hellebori nigri 59i urbanun% ib. jalapae 592 Ginfeng 269 jalapii 595 Glecoma hederacea 342 ligni Campechcnfis 593 Glycyrrhiza glabra 228 mimofae catechu Gramen 348 opii 594 Gramina 357 papaveris albi 592 Grana paradifi 328 querciis ib. Granafum 289 rufae graveolentis 59i Gratiola officinalis 229 iabinas 592 Gruinales 35<5 faturni 477 Guaiacum officinale 230 fennae 594 Gummi Arabicum 256 > 344 Valerianae fylveftris aftragali tragacanthae 164 refinofum 596 mimofae Niloticae 256 tragacanthae 164 F. refina aloeS perfoliatae *33 ammoniaci 136 Faba 349 342 bubonis galbani 170 Fagara odtandrai convolvuli fcammanii 205 Ferrum 222 ferulae afTae fcetidae 225 ammoniacale 450 gambogia 308 tartarffafum 45i guaiaci officinalis 230 vitriolatum 324,447 juniperi lyciae 241 Ferula affa fcetida 225 kino 242 Ficus Indica religiofa 342 myrrha 263 carica 226 fagapenum 300 Filices 357 Gynandria 3 S3 Filix fcemina 34^ mas 285 H. Flammulajovis 34i Flores benzoes 37i Haematoxylon Campechianum 2%t martiales 45° Hedera terreftris "42 ftilphurisloti 359 Hederaceae 355 zinci 479 Helleborafter 232 Fceniculum aquaticani 345 Helleborus albus 321 Fcenuin Grsecum 319 fcetidus 232 Formica rufa 342 niger ib. Fraxinusornus 226 Hepar fulphuris 389 Fuligo ligni combufti 227 Heptandria 35 2 Fumaria officinalis ib. Hefperideae 35. pimpinellse anifi ib. pini laricis pul- egii ib. 688 Latin Index. Page. Oleum volatile rorifmarini oific inalis ib. rutae ib. fabinae ib. faffafras ib. feminum fcenicul 1 dulcis ib. terebinthina; pu- riffimum 5i2 Olibanum 241 Oliva 267 Onifcus afellus ib. Ononis fpinofa 344 Onopordium acanthium ib. Opium 270 purificatum 596 Opobalfamum 142 Opoponax 274 Orchideae 357 Orchis latifolia, &c. 345 Origanum dictamnus ib. Origanum majorana 268 vulgare **. Oryza fativa 345 Oftrea edulis 268 Oftrearum teftae praeparatae 416 Ovis aries 269 Gvorum teftaf praeparatae 416 Ovum 275 Oxalis acetofella 269 Oxidum antimonii cum phof- phate calcis 432 antimonii cum fulphure per nitratem potaffae 423 antimonii cum fulphure vitrificatum 424 antimonii vitrificatum cum cera 4?5 arfenici 156 ferri nigrum 224 ferri nigrum purifica- tum 444 ferri rubrum 44S hydrargyri cinereum 4^5 hydrargyri rubrum per acidum nicum 46 S plumbi album 283 plumbi rubrum ib. plumbi femivitreum 284 zinci r 478 zinci impurnm 328 zinci imptirum prae- paratum 480 Oxycoccos 348 Oxymel aeruginis .548 colchici 547 Oxymel fcillae fimplex Page. 54« 54$ P. Paeonia officinalis Palmae 354, Panax quinquefolium Papaver album erraticum rhceas fomniferum Papilionaceae Pareira brava Parietaria officinalis PafTulae minores Paftinaca opoponax Pechurim faba Pentandria Pentaphyllura Pepo Perfonatae Peruvian us cortex Petroleum Barbadenfe fulphuratum Petrofelinum Phafianus gallus Phellandrium aquaticum Phofphas calcis fodae Phyfeter macrocephalus Phytolacca decandra Pilulae aloes compofitae cum affa fcetida cum colocinthide cum myrrha aloeticae ammoniareti cupri affae fcetidae compofitae galbani compofitae ■ hydrargyri opii opiatae Plummeri rhei compofitae fcillae fciliticae ftibii compofitae Thebaicae Pimento Pimpinella alba anifum faxifraga, Pinus abies balfamea 345 357 269 270 ib. ib. ib. 35<5 196 274 349 274 345 35i 287 341 355 189 168 167 503 i52 275 345 41S 394 275 345 631 ib. ib. 622 620 623 622 623 ib. 625 ib. 626 625 ib. 626 ib. 625 264 345 276 345 276 Latin Index. 689 Pinus larix fylveftris pinea fativa Piper cubeba Indicum longum nigrum Piperita? Pi fees Piftacia lentifcus terebinthus Pix Burgundica liquida Plantago media pfylliurn Plumbum Polyadelphia Polyandria Polygala amara vulgaris fenega Polygamia Polygonum biftorta Polypodium filix mas vulgare Pomaceae Populus balfamifera Potaffa cum calce Potentilla reptans Potio carbonatis calcis cretacea Praeparatio quofundam, aqua non folubilium 415 Prunus cerafus 346 domeftica 287 Gallica ib. lauro cerafus 346 fpinofa 287 Prunus fylveftris ib. Pfyllium 345 Ptarmica 328 Pteris aquilina 34<> Pterocarpus fantalinus 288 draco ib. Pulegium 254 Pulparum extradtio 498 praeparatio 499 Pulfatilla nigricans 329 Pulvis aloes cum canella 599 aloeticus cum guaiaco 600 cum ferro ib. antimonialis 432 Page. 276 277 345 ib. 28 r 175 28r ib. 357 35° 282 ib. 280, 276 280, 277 345 ib. 282 353 352 345 346 384 354 285 ib. 34<5 35<5 346 378 380 287 552 ib. Page. Pulvis carbonatis calcis compof- itus ib. cretaceus ib. cretae compofitus 603 cum opio. ib. chelorum cancri compof- itus ib. cerufTa? compofitus ib, contrayervae compofitus 603 Doveri . ib. hydrargyri cincreus 465 ipecacuanha? et opii 603 compofitus ib. jalapae compofitus 604 myrrhae compofitus ib. opiatus ib. fcammonii compofitus ib. ■ cum aloe ib. cum calomela>ne ib. fennae compofitus 606 ftanni 477 ftibiatus 433 ftypticus 606 fulphatis alumina? com- pofitus ib. tragacanthae compofitus ib. Punica granatum 289 Putaminea? 356 Pyrethrum 146 Pyrus cydonia 289 Qc Quaffia excelfa fimaruba Quercus robur cerris R. Ranunculus albus Raphanus n*fticamis Refina alba amyridis Gileadenfis 290 ib. = S9 *9° 291 329 202 280 ib. 142 aromaticus 600 fari Europaei compofitus ib, copaifera? officinalis 207 flava 597 guaiaci 230 piniabietls 276,280 balfamea? 276 laricis ib. fylveftris 277, 280 piflaciae lentifci 282 p.teiocarpi draconis 288 6S0 Latin Index'. ^.habarbarum . Sibiricum RhamnUs catrjarticus Rheum palmatum undulatum Rhododendron cryfanthum Rhceadeae Rhus toxicodendron Ribes nigrtim rubrum Rfcinus communis Rob fambuci Rofa canina centifolia Damafcena Gallica rubra Rofmarinus officinalis fylveftris Rotaceae . « .. . Rubia tiirctoruni Rubigo ferri Rubus ardticus caefiu? chamaemorus frutrcofus idaeiis 2< Rumex acetofa aquaticus acutus Ruta graveolens Page. 292 346 291 292 346 294 356 294 295 ib. ib. 497 297 296 ib. ib. ib. 292 343 355 297 445 346 ib. ib. ib. h 346 298 34^ ib.. Sabadilla $abina . , Saccharum non purificatum officinarum purificatum puriffimum rubrum faturni Sagapenum Sago Sal alkalinus fixus foffilis puri- ficatus ammoniacus benzoini communis exficcatus cornu cervi diureticus Glauberi mar ris muriaticus 349 241 398 ib. ib. ib. ib. 475 300 34i 392 259 37i 26b 396 4°5 385 396 447 i6o Sal polychreftus Rupellenfis fuccini purificatus tartari Salep Salix alba fragilis 30O( pentandra vitellina Salvia officinalis Sambucus ebulus nigra 5 Sanguis draconis Santalum rubrum Santonicum Sapo Saponaria officinalis Sarcocolla Sarfaparilla Sarmentacea? Saffafras Satyrium Scabiofa arvenfis- Scabrida? Scamnionium Scandix cerefolium Scilla maritima exficcata Scilla? praeparatae Scitamineae Scordium Scorzonera Hifpanica Scrophularia nodofai Secale cereale Sedum majus Sempervivtim tedtoram Seneka Senna Senticofa? Sepia odtopoda Sepiariae Serpentaria Virginiana Serpyllum Sevum bovinum ovillum praeparatum phyfetens macrocc- phali Siliqua dulcis Siliquofa? Simarouba Sinapis alba Sinapis nigra Sifymbriuni nafturtiura Sium nodiflorum r..gc. 3*3 398 373 ib. 381 345 347 347 ib. ib. 301 347 3©t 288 ■ib. 161 302 347 3°3 3°d 355 247 3451 347 357 205 3471 303 492 ib. 357 3i* 347 i6. ib. ib. ib. 284 181 356 34? 35.< '.'3 348 340 269 629 2 75 340 35* 289 304 3°5 ib. ib. jirglih Iridcx-. o^ ?>i Page. Smiiax china farfaparilla 347 306 Solanacea? Solanum dulcamara 355 306 Solidago virga aurea 3°7 Solutio acetitis zinci 4«3 muriatis baryta: 412 calcis. 417 fulphatis cupri com- pofita 441 zinci 482" fepartiuin fcoparium 3°7 Spermaceti 275 Spigelia anthelmia 347 Marilandica 3°7 Spina cervina 291 Spiritus setheris nitrofi 489 vitriolici 485 compofitus 486 alkali volatilis 401 aromaticus 581 fcetidus 521 ammoniae 401 aromaticus 58i compofitus ib. fcetidus 52t fiiccinatus 582 linifi compofitus 520 camphoratus 562 cari carvi 5i9 carvi ib. cinnamomi ib. juniperi communis compofitus 526 lauri cinnamomi" 5r9 Iavandula? fpicae ib. compofita 570 menthae piperitae 5i9 fativae ib. Mindereri 408 myrifticae mofchata? Si9 myrti pimenta? ib. fiucis mofchata? ib. pimento ibi. pulegii ib. raphani compofitus S-i rorifmarini officinalis 520 vinofus camphoratus 562 Spongia officinalis 307 ufta 493 Squama? ferri purificatae 444 Stalagmitis cambogioides 308 Stannum 3°9 Sia^hifagria 217 Stellatae 355 Stibium 147 nitro calcinatum 4-3 muriatum caufticum 43° X* Page. 422 217 348 310 ib, 343 3*9 598 213 310 459 4*4 470 495 £ 3 495" Stibium praeparatum Stramonium officinale Strychnos nux vomica; Styrax beuzoin calamita liquids officinale purificata Sub acetis cupri Sub boras foda: Sub murias hydrargyri praecipitatus et ammonia? flavus Succt ad fcorbuticos Succinum ' Succulents ..... Succus cochleariae officinalis * compofitus concretus fraxini orni 226 rhanihicathartici 291 fpjffatus aconiti napelli 495 atropa? bel- ladonnas ib. cicuta? 497- conii maculati 496 byofciamitiigri ib. ladtuca? virofae ib. limonis ib. inomordicae eiaterii ib, papaveris fom- niferi 370" ribis nigri 495 fambuci nigri 496 3ir aluminae eAficcatus barytas cupri ferri exficcatus 448 magnefia? 313 potaffae 3S7 cum fulphure 389 focirc 396 zinci 325, 481 Stilphur antimonii prxcipitatum 427 360 4-6- 427 3H 359 J47 427 Salphas 312 42 x 313 214 —4, 447' praecipitatum ftibiatum fufcum rufum fublimatum * lotum .Sulphuretum antimonii praecipitatuiri hydrargy ri nigrum 47 7. potafla? 389 692 Latin Index.' Page. Super fulphas aluminae et pot- affae 31a Super tartris potaffae 314 impurus ib. Sus fcrofa 315 Swietenia febrifuga 316 mahagoni ib. Syrupi 536 Syrupus acid! acetofi 537 allii ib. althea; officinalis ib. amorni zing.beris 538 balfamicus 545 caryoj,hylh rubri 540 citri auranrii 53S med :ci 539 colchici autumnalis 5+0 1 communis 537 corticis aurantii 539 croci 541 dianthi caryophylli 540 mannas 541 opii 54a papaveris fomniferi ib. albi tb. erratici 543 ihamni cathanici ib. rofae 544 Gall cae it. centifolis? ib. facchari rubri 298 fcillae maritimae 544 fimplex 537 fpiiue cervin« 543 fucci frudlus m»ri 539 ■ ribis nigri 540 ida?i 539 limonis fucci ib. Toluifera? balfami 545 Tolutanus . ib. viola? oderata? ib. zingiberis 538 Symphitum officinale 348 Syngenefia 3S3 T. Tucamahaca 34:, 346 Tamarindus Indies; 316 Taraxacum 248 Tanacetum vulgare 3^7 I artari cryfialli 3H Tartarus emeticus <433 Tartarum 314 folubile 391 ftibiatum 433 vitnolatum 387 faga. Tartris antimonii 433 potaffae 39i et fedgs 398 Terebinthiria ■) Chia 2\T, Veneta 276 vulgaris 277 Tetradynamia 35? Tetraadria 351 Teuciium chainaedrys 348 d'am.^pitys ib. nid ..a 3i7 fcordium 3i8 Theobroma cacao 348 Thus 276, 280 Thymus ferpyllum 348 vulgaris ib. Tindtura aloe's a.therea 378 foCvyCoiina? 557 cum myrilu 558 compofira 559 amomi rer>entis ib. ar:ltolocliiaeferpentariae56Q an matica 569 affje fcetiJa? 560 an; antii cortic'» 561 ball arm Peruviani ib. Tolutani 577 benz»es coli.pofita 561 camphorae 563 canthar.dum 571 cardaniomi 559 compofita ib. cafcarilla? 562 caflia? fennae compofita 563 caftorei ib, compofita 582 catechu 571 cinchonae ammoniata 583 compofita 564 officinalis ib. cinnamomi 569 compofita ib. Colomba? 565 convolvuli jalapa? ib. corticis Peruviani 564 ■^ compofita ib. croci 566^ digitalis pnrpurea? ib. ferri acetati 452; ammoniacalis 451 muriati 449 galbani 566 gentiana? compofita 567 guaiaci 567. 583 ammoniata /'-'■. •fLatin Index. 693 Tinctura volatilis hellebori nigri hy >fci;nni nigri ja'apa? Japonica kino lauri cinnamomi compofita lavandulae compofita meloes veficatorii mimofa? catechu mofchi niyrrhae muriatis ferri opii camphorata ammoniata rhabarbari Pagfr" 583 567 568 £«5 57i 563 569 ib. 570 57i ib. 572 ib. 448 573 ib. 5?4 574 compofita ib. 575 rhei amara cum u!oe $74. gentiana 575 paln-ati 574 rofarum 525 fabina; compofita 575 faca 585 faponis 575 cum opio 576 fcilla? ib. fennae 563 ferpentariae 560 theha'ca 573 Toluitera? balfami 577 Tolu tana ib. va'erianaa ib. vera'ri albi ib. zingiberis 578 Toluifera balfamum 318 Tormentilia ereda ib. Toxicodendron 294 Tragacantha gummi 164 Triandria 351 Tricocca? 357 Trifolium melilotus officinalis 348 paludof'um 254 Trihilata? 357 Trigonella foenum graecum 319 Tripetaloidea? 357 Triticum aeftivum 319 hybernum ib. repens 348- Trochifci carbonatis calcis 616 cretacea ib, glycyrrhiza? ib. cum opio 617 compofiti ib. Page. Trochifci gummofi 618 amyli ib. ma;'iiefine ib. nitratis potaffae 619 nitri ib. fulphuris ib. Turpethum minerale 470 Tuffilago farfara 320 Tutia 325 pra?parata 480 u. Ulmus campeftris Umbellatae Unguentum acetitis plumbi acidi nitrofi adipis fuilla? album calcis hydrargyri albi cantharidis cerae cerulfae acetatae coeruleum elemi compofitum epifpafticum forti- us mitius hellebori albi hydrargyri fortius mit'■■:■:'''■ '; M^€i .; :•.••;'.:•;-:;mi:,.r^.-Ji::>;*,W#Mw . . .i*,....... i-.. . —.-r- .u..jii^'lrI;-.flj,Ht.(