NATIONAL LIBRARY OF MEDICINE Washington Founded 1836 U. S. Department of Health, Education, and Welfare Public Health Service -?*^. *LJL ^ OBSERVATIONS / /«? Z-. ON THE DISEASE CALLED THE PLAGUE, ON THE DTSENTERT, THE OPHTHALMY OF EGYPT, AND ON THE MEANS OF PREVENTION. WITH SOME REMARKS ON THE YELLOW FEVER OF CADIZ, AND THE DESCRIPTION AND PLAN OF AN. HOSPITAL TOR THE RECEPTION OF PATIENTS AFFECTED WITH EPIDEMIC AND CONTAGIOUS DISEASES. BY P. ASSALINI, M. D. One of the Chief Surgeons of the Consular Guards, &c. &c. TRANSLATED FROM THE FRENCH BY ADAM NEALE, Of the University of Edinburgh, Member of the Royal College of Surgeons of that City, and late Suigeon of the Shropshire Regiment of Militia. TO WHICH IS ADDED, A LETTER CONCERNING /^ THE SEASONING, OR YELLOW FEVER OF THE WEST-INDIES. BY GEORGE PINCKAKD, M. D. &c. NEW-YORK: Piinted and sold by T. & J. SWORDS, Pointers to the Fafnltj» of Physic of Columbia College. 1806V Ct,> Vl/,.i(eTON.-D.5-,J; V. _. w \ *,, *y ILSZtf TRANSLATOR'S PREFACE, AMIDST the variety of acute diseases which have at different times depopu- lated the earth, and imperiously called forth the energies of governments, and the solicitude and exertions of indivi- duals, the plague has long maintained a fatal pre-eminence. After ravaging, for several centuries, the finest countries of Europe, Asia, and Africa, it seems at length to have usurped a lasting domi- nion over the imperial city of Constan- tinople, the coast of the Levant, and the whole country of the Ptolomies, where, conjoined with the sloth, filth, and misery of the inhabitants, it bids defiance to the power of medicine. ( iv ) Happily for this country, we have long been strangers to its attacks. A period, indeed, of more than a century has elapsed since it has been observed in this metropolis. But although thus fortunately estranged from its destructive influence, we must still continue to feel a lively interest in the progress of this disease, and more particularly since the occurrence of the late campaign in Egypt. That country may again be- come the theatre of war, and it is there- fore doubly incumbent on us to procure every possible information on the sub- ject of its diseases, in order that we may the better be enabled to preserve the valuable lives of our brave troops. It is to be sincerely regretted, that none of our own countrymen who be- longed to the army of Egypt have, as yet, come forward with the information which they must have collected on this disease; and we are therefore constrained, ( v ) for the present, to have recourse to the writings of the medical officers of the French army, who, it may here be re- marked, possessed more extensive means of acquiring an accurate knowledge of the subject than our medical staff, ow- ing to their longer residence in Egypt, and to their having had a larger field for practice and observation, from the superior magnitude of the French army. But independently of the utility of the knowledge of the plague and epi- demics of Egypt, in a military and po- litical point of view, the subject pos- sesses the most general and extensive claims to our attention. A just idea of the nature of diseases is only to be ac- quired by a knowledge and investigation of various facts; and that physician who, to a sound judgment, unites the most extensive acquaintance with the maladies of different countries, will cer- A2 ( vi ) tainly be, ceteris paribus, the best prac- titioner. Such then being my views in under- taking the translation of this work, I trust that it will fulfil the object pro- posed ; and I sincerely hope, • that a knowledge of the facts therein con- tained may conduce to throw further light on the contagious and epidemic dis- eases both of this and other countries. INTRODUCTION BY THE AMERICAN PUBLISHERS. VyNE of the objects of the work of Assalini is to combat a prejudice among the European nations, that the disease which they call the Plague is contagious. He derives his facts and arguments from the Mahometan regions which he has visited; and they come with great force from an eye-witness of so much intelligence and candour. But there is another source whence the like consi- derations may be deduced. We mean the narratives of the people themselves, into whose cities the contagion of plague has been pretended to have been im- ported from the Turkish countries. The ( viii ) greater part of these relations will be found defective in their proofs; and no- thing more is necessary to evince their inconclusiveness than to peruse those publications with this object in view. If it turns out, upon investigation, that this disorder is really not contagious, and that a great noise has been made about it without sufficient cause, and for no good purpose, then a great error in society will be corrected, and many of the evils consequent upon it will be removed. This inquiry is the more important, be- cause the importers of plague from the Levant argue in about the same man* ner with the importers of yellow fever from the West-Indies. The misrepresentations and mistakes which have prevailed in America on the subject of yellow fever, have been pretty fully detected and exposed. It has, however, been a work of time and labour; but in a country, and among ( ix ) a people where the utmost freedom of inquiry is allowed, and where the whole •body of citizens have a deep interest, as well as curiosity, to examine thoroughly the alleged contagiousness of their au- tumnal fevers, there has been collected a great mass of evidence against that opinion within the last ten years. And the result of this minute and patient dis- cussion, that there is no morbid venom or poison sui generis produced by any secretory action of the vessels during a yellow fever, whereby that disease xan be communicated from one person to another, has led many gentlemen to doubt the contagiousness of the distem- per, which, in a small region of Europe, bordering on the Mediterranean sea, be- tween the Adriatic and Atlantic, has been denominated the Plague. The con- nection between the United States and the North African powers has strength- ened these doubts, by affording us strong i x ) evidence against the opinions prevailing among the Christian nations, through Dr. Cowdrey, an American prisoner at* Tripoli, and Dr. Davis, Consul at Tunis, in Barbary. And the expeditions to Egypt have had this good effect, that they have enabled several cautious ob- servers to see for themselves that ma- lady, the very name of which, like that of an apparition among weak and cre- dulous people, fills the inhabitants of Christian Europe with terror; and have induced them to bear witness against its contagious nature. Contemplating the alarming stories about the importation of the plague into Christendom, and the expensive esta- blishments that have been made for the purpose of keeping it out; it appears ex- tremely probable all this dread of con- tagion, and the rigour of quarantines and lazarettoes to guard against it, have, in reality,, no better foundation than the ( xi ) equally positive, though delusive tales propagated about our domestic yellow «fever. With this view, Bertrand's Rela- tion Historique de la Peste de Marseille, en 1720, is worthy of being read. As this is the great authority whence the contagionists derive their arguments, a copy was sought, and fortunately pro- cured from the very place whose cala- mities are therein related. This book is the more worthy of perusal, because, by establishing the belief of contagion in plague, it gave rise to the famous code of regulations which were published in 17 80, under the title of Reglemens du Bureau de Sante. And these rules and orders of Marseilles, predicated upon the existence of a most subtil and viru- lent pestilential .contagion, have had a credit given to them almost as exten- sive and obligatory as the maritime laws of Rhodes and Oleron. The narrative of Bertrand is the ground- ( xii ) work of a mighty superstructure. His historical relation serves the same purpose to prove the contagiousness of the plague, and its introduction from Syria into France, as Chisholm's Essay answers to show that the Malignant Pestilential Fever was carried from Guinea to the West-Indies and the United States. The improbable and unfounded nature of the latter account is now generally un- derstood, and candid members of the profession excuse, while they lament such a capital mistake in so sensible and respectable a writer. This discovery na- turally prompted an inquiry into the weight and pertinency of the evidence which Bertrand's volume contains. For, if it should be found to be weak or irre- levant, then the vision about contagion vanishes, and all the apparatus to keep it away becomes vain or useless. " The facts, (says Dr. Mitchill, in his letter to the Board of Health in New- ( xiii ) York, September 10, 1806), on the oc- currence of the memorable mortality at Marseilles in 1720, as I collect them from Bertrand's book, warrant no such conclusion as he has drawn from them, and may be summarily stated thus: That city had suffered, at different times, nineteen visitations of plague that were important enough to be remembered; this was the twentieth. This year, corn and other necessaries were dearer than common, not so much, says the author, from actual scarcity, as from the remark- able want of money; but which, to all poor people, amounted to the same thing. " The season is described as not being remarkably different from common years. In the course of June, the inhabitants be- came sickly. The disease began among sailors and indigent people near the har- bour, and gradually extended the circle of its action. The people and their ma- gistrates grew uneasy, and expressed a ( xlv ) different opinions about it, and, on re- ferring it to the members of the medical profession, they, as usual, also differed in opinion. One class of them expressed their solemn conviction, that it neither proceeded from a vitiated atmosphere nor a scantiness of food, but was derived from contagion imported from Sidon, in Syria, on board a ship which sailed thence January 31, and arrived on the 25th of May, with a clean bill of health, and a sickly crew, at Marseilles. Mr.Bertrand, who is the chief of this sect, says, the vessel also touched at Tripoli and Cyprus, and brought certificates of health from both those places. The Captain, during the voyage, had put into Leghorn, on account of the wretched and dying con- dition of his crew, and had received a certificate from a physician and surgeon there, purporting that they died of a ma- lignant pestilential fever. Several other vessels arrived from the same ports about ( xv } the last of May and in the beginning of June, bringing foul bills, there being suspicions and appearances of plague; but none of their crews are stated to have been unhealthy. On the other hand, there was a numerous and intelli- gent body that contended in favour of its local origin at home. These ascribed the endemic to atmospheric distempera- ture, vile and scanty food, and to fear and the depressing passions. This side of the question was maintained strenuously in numerous publications, by Mr. Deidier, Professor Maille of Capors, Dr. Boyer of Toulon, and Professors Chicoyneau and Verny of Montpellier. All those were men of high character, and, ex- cept one, were eye witnesses of the dis- temper; beheld it in its worst forms, and deliberately spoke and printed their conviction, that it was an ordinary ma- lignant disease, and by no means conta- gious. { xvi ) '" The points of importation and domes- tic origin were as fiercely disputed at that time, as they have ever been since. Mr. Bertrand, Mr. Pons, Mr. Peysonnel, bro- ther Victorin, and the other persons who were contagionists, ascribed all the mis- chief to the arrival of the vessels from the Levant, and satisfied themselves of the landing of the contagion at the la- zaretto; whence, after having multiplied and recruited itself, it slipped insensi- bly into the neighbouring part of the town, crept insidiously from house to house, and from street to street, until it gained possession of the whole; and, finally, glided by the same secret and silent advances into the adjoining coun- try. Their opponents considered all this to be prejudice, mistake, and delusion. There was no proof, they said, that con- tagion existed in the Syrian and Cyprian ports when the accused ship left them. If contagion had existed, there was no ( xvii ) evidence of its having been taken on board. In a voyage of nearly three months' duration, nothing was more common than the existence of sickness among a crew. There was no necessity of charging such a sickness to the ports whence they sailed; for it was much more probable that it arose on ship- board, and was of strictly local origin there. The occurrence of fevers, and of death during the passage, had no- thing to do with the places whence they took their last departure. Persons at sea had no more security against sickness and mortality than when on shore, and therefore might, in the nature of things, become infirm, and even end their days, from, causes arising within the vessel it- self. So, if a ship had arrived in a sickly and unclean condition at any city, it did not follow that her unhealthiness and filth must be spread far and wide among the inhabitants. Independent of all these a 2 ( xviii ) considerations, on examining the facts it was found, that this dangerous dis- ease had been progressing, by regular steps, among the lower class of people; that it resembled the home-bred malig- nant distemper of 1709 and 1710; that it was connected with the wretchedness and famished condition of the poorer in- habitants, who compose the great body of society; and, in short, that the popu- lace, starving upon meagre and damaged food, became sickly of course from the common necessity of the case. The most decisive proof was adduced, that before the arrival of the suspected ship, to wit, early in May, and in April, and even during part of the preceding year, 1719, diseases, accompanied with buboes, pa- rotids, and carbuncles, had appeared. The sudden deaths of the porters were not owing to a blast of pestilential con- tagion, inhaled from the bales of goods they were landing, but to debility and ( xix ) impoverishment consequent upon bad living, and to the sudden and total failure of their strength when applied to carry a load. The attacks were in situations so remote from each other, and the pa- tients so utterly free from all communi- cation, cither with one another or with the ship and her contents, that the dis- temper was truly endemic in its origin, uncontagious in its nature, and as much a domestic malady as any other that ever afflicted the inhabitants. " If Mr. Malthus, said Dr. Mitchill, had thought of this case, he could not have given a better example than it af- fords, of the increase of human beings beyond the amount of subsistence ; and of the occurrence of a pestilence, to rid society of its superfluous members, and reduce the number of mouths tothequanr tity of aliment provided to feed them. " While this severe, though necessary work was going on, of trimming off the ( xx ) luxuriance and overgrowth of their po- pulation, the Marseillians bore it with the patience with which mankind gene- rally endure misfortunes. Matters went on from bad to worse, until near the end of July, when an opinion was propa- gated that the disorder among them was the true Asiatic plague. This was at first violently opposed by the multitude. The authors of it were reviled and insulted. A more wilful and pernicious falsehood, they declared, had never been propa- gated to the injury of the Burghers. But although these were incredulous, there were, at length, persons enough to give full credit to the story. The rumour that the plague had been brought from .the Turkish dominions, was propagated far and wide. It gained believers almost in every place to which it extended; and in a very short time this unhappy city was put under an interdict, and cut off from the intercourse of society, lest the plague. ( xxi } by which it was desolated, should over- whelm the adjacent settlements, villages and towns by its contagion. " As soon as the disease was declared to be the plague, a series of new proceed- ings and sorrows began, infinitely more tragical than all that had happened be- fore. The surrounding places refused to bring supplies to market. The par- liament indeed forbade the intercourse under severe penalties. Barricades were ordered for the purpose of keeping them in. They were prohibited going into the country for safety, or even to buy provisions. The immediate consequence was an extreme and general failure of food. The bakers were destitute of corn and meal. As early as the third of August the bread fell short, and the multitude marched from one street to another, insulting the bakers at their houses. They were agitated by rage and tumult. At length, to prevent im- ( xxii ) mediate famine, two markets were esta- blished on the great avenues, six miles from the city, and another on the sea- side. These were fortified by double barriers, officers and guards, to allow sales, but to prevent communications. Thus were these ill-fated people sur- rounded, and, in great numbers, literally starved to death. " For, though these supplies relieved the scarcity in some measure, there were multitudes who received no benefit from them. They were two leagues from the city. The poor, the sick, and the helpless could not travel so far. Many of them indeed were unable to buy, had the market been held at its accus- tomed place, or at their own doors. The price of every thing immediately rose. Labour became dearer than ever was known. The stores of wine, so ne- cessary an article of diet to the French, were nearly exhausted. Butcher's meat ( xxiii ) was very difficult to procure upon any terms. In short, famine became more formidable than the plague itself. The original scarcity, bad as it was, did not bear a comparison with the hunger, suf- ferings, and mortality that resulted from these ill-judged regulations. The cala- mity of 1720 ought to be denominated the famine, rather than the plague of Marseilles: for clearly more appear to have been starved than to have died in any other way. " The labouring classes, and those who do the work of society for hire, perished first; and the greater part of them having died, and there being none to replace them, it was impossible to get work done, even for money. A large pro- portion of male and female servants, waiters, and laqueys also famished at an early period; and it was oftentimes quite out of the power of the most wealthy persons to procure domestics to ( xxiv ) perform the ordinary services of life, by the highest wages. The survivors were obliged to perform their own labour and attendance. In the progress of the sea- son, many of the butchers, bakers, and fishermen yielded their lives to the pres- sure of the common calamity. The dis- tress of this was sorely felt by all the in- dividuals yet alive. Of these, the re- maining poor were starving for want of their accustomed employment; and the rich, because they could not exchange their money for common necessaries. The houses, throughout all their apart- ments and recesses, were strewed with the dying and the dead. All the streets were covered with carcases. The grave- diggers had disappeared. LTndertakers and sextons were not to be found. About a thousand corpses were daily thrown in- to the streets to putrify, until, at length, a passenger could scarcely walk without treading on them. In some places he ( XXV ) was obliged to tread on them. In the public walks, and before the Church doors, they were piled up in large heaps, men, women, and children. Persons of all ages and conditions were under- going the process of corruption, as they overspread the pavements, and filling the atmosphere with their noxious ex- halations. And this domestic source of pestilential effluvia was itself enough, without other agents, to have depopu- lated the city. To augment their dis- tresses, an opinion was started, that the contagion was carried from one person and place to another by dogs. Instantly a war of extermination was declared against these poor animals, and the land and the water stank with the septic fluids proceeding from thousands of them that were killed. This shocking condition of things continued until to- ward the end of September. And, con- sidering these concurring causes of mis- b ( xxv'i ) ,-dhief, one is apt to wonder that the mortality was limited to fifty thousand. It might be reasonably expected, that under such circumstances, in a popula- tion of eighty thousand, a much larger proportion would have been destroyed. " Finally, the surviving confessors, physicians and surgeons, exhausted and discouraged by all they had suffered, and by all that they feared, ceased at once, to administer their services, and aban- doned the wretches to their fate. When these men withdrew their attendance, and sought their own safety by flight, the misfortunes of the miserable inhabit- ants were wrought up to the highest pitch. They had long endured the depressing operation of fear. In many the apprehension of danger had been changed into ghastly terror. But now the small remains of fortitude forsook them, and they sunk under the pres- sure of dejection and despair. Their ( xxvii f minds and bodies became the prey of a debility which ended in languor and death, or which predisposed them to receive morbid impressions that they might otherwise have repelled. The dread of the plague, when augmented by the horror of desertion by all who could administer help or comfort, was a fatal aggravation of their woes. " These woes, however, had some alle- viation toward the termination of the calamity. For, during the season of Lent, the good Bishop, the celebrated Castelmoron, who, by an ordinance of 24th February, dispensed with the rule of rigid abstinence, and permitted the use of meat four times a week, substituted, instead of fasting, the recital of certain particular prayers. On the 4th of March, solemn application was made in the Jesuits' Chapel, to St. Francis Xavier, for his intercession with Heaven to ar- rest the mischief; and on the 21st ( xxviii ) a similar service was performed to the sacred heart of Jesus, in the Capuchin's Church, for the same purpose, and con- tinued in both for nine or ten days. Altars were erected in various public places, and mass celebrated there. Even the ancient custom of carrying the via- ticum to the sick in every parish was permitted during the fortnight of Easter. In like manner a procession had been formed on the 31st of December, by the Bishop carrying the holy sacraments, attended by the surviving clergy, around the ramparts. He pronounced the be- nediction at the gates of the town, and in the ditches where the dead had been deposited, to implore the mercy of the Lord upon those unhappy defuncts whom the calamity had deprived of ec- clesiastical sepulture. And, on the 15th of the preceding November, the same pious prelate had walked bare-footed, with a torch in his hand, to an altar ( xxix J which had been erected in the park, and after having celebrated mass, and given the consolation of his advice and exhortation to the people, he ascended to the top of the steeple in the parish Church of Accoules, and pronounced a blessing upon the whole city at once, while the ringing of bells, and the firing of cannon notified the inhabitants to join their prayers to those of their Bishop. It was seriously agitated between two of the great churches, whether the relics of the saints ought not to be brought forth to view; but, owing to a difficulty in settling certain points of ceremony and etiquette, these sacred treasures were not exhibited. " This accident, therefore, partook much-more of a famine than a pestilence, since the true causes were; 1. Scantiness and badness of food; 2. An unhealthy season among the poor and labouring orders; 3. The consternation on their b2 ( XXX ) distemper being proclaimed the true Turkish plague; 4. The starving condi- tion to which the inhabitants were fur- ther reduced by the regulations of the police; 5. The envenomed quality of the atmosphere, from the rotten bodies of unburied men and dogs; 6. The prostra- tion and annihilation of animal power by grief, despondency, and the most depressing passions. And still, notwith- standing all these circumstances and occurrences, enough in all sober consi- deration to desolate a city, it has been the fashion, ever since Bertrand's book was published, to quote it as the highest authority in favour of an imported conta- gion that stirred up such complicated and unspeakable mischief; mischief which derived infinitely more of its fatality from bad management, than its own inherent malignity. This author has written an elaborate and sensible account of the sickness and its accompaniments. He ( xxxi ) is as impartial as can be expected in a person who is a strong and zealous advo- cate for contagion and importation. On the occurrence of a more than common sickness at Marseilles, it became a sub- ject of rational inquiry to discover its cause. Mr. Bertrand adopted the belief of its introduction from a foreign port, and patched up a story about contagion brought from Sidon and Tripoli. I say, patched up a story, because the exist- ence of such contagion has never been proved by the evidence of one of the senses. The contagion is a mere conceit of the mind; and all reasoning upon such a visionary and fancied agent can be but hypothesis, and have no better claim to our assent than the fluid of magnetism and the ether of gravitation. Upon such a conjecture, all the public proceedings were founded; an assump- tion not near so worthy of our assent, as if it had been said that the invisible angel ( xxxii ) ©f destruction had literally and bodily descended, sword in hand, to execute a heavy judgment of his Lord, " On reading this famous book, and comparing and weighing the evidence it contains, I am entirely convinced that the importing party have failed to sup- port their assertions by, I will not say logical or legal proof,, but even by that evidence which is fit to convince a plain understanding here^ in North-America, after a lapse of more than fourscore years. " Are we then to give credit to the phantom, which deceived the people of France to the destruction of the Marseil- lians, and misled their intelligent his- torian himself? By no means. Let us rather sift the whole testimony, and, dis- regarding the erroneous conclusions of our predecessors, decide upon the facts for ourselves. If we do so, we '•hall find the plague of Marseilles, which has been ( xxxiri ) quoted and dwelt upon as the clearest case of imported contagion that ever ex- isted, to be unsupported by the necessary evidence, even on the allegations of its warmest advocates." Having stated thus far a summary of the contents of one of the most cele- brated works on the importation of plague into France, we shall next insert the ac- count of its pretended importation into Sicily, in 1743. This is taken from Dr. Mitchill's letter to Dr. Rodgers, the Health Officer of the port of New- York. *' Analysis of Turriano's Treatise onthe Plague a/Messina, in Sicily, 1743; and an Account of the Use of the Rack and Torture to prove the Dis- temper contagious. " The city of Messina, in Sicily, suf- fered a dreadful visitation of sickness in 1743. An account of it was written by ( xxxiv ) Horace Turriano, and published at Naples, in 1745, under the title of■ Me*- moria Istorica del Contagio dclla Citta di Messina del Anno 1743. Turriano's book contains several particulars well worthy of notice. He says that the spring of the year which preceded the pestilence was rough and cold. South- erly winds prevailed, which were stormy and cloudy. The cold at the time of the equinox was scarcely less than that of the preceding winter. But the winds continued to blow from the same quar- ter, and an epidemical catarrh began to prevail among the people. Soon after an alteration was perceived in the type of the ordinary diseases of the place. This new form of the usual distempers manifested itself in coughing, hoarse- ness, pain in the breast, swellings of the throat and glands of the neck, with other symptoms of the true and spurious an- gina. In some there were swellings of X XXXV ) the glands in the groins and near the ears, and fevers wore a malignant aspect. " Some of their prophets had foretold a sickly season, and now they began to apprehend a mortal epidemic, similar to those which, at different times, had af- flicted Genoa, Alexandria, Milan, Naples, Rome, and other places. " In this state of things they made a discovery, which satisfied all their minds what the true cause of this sickness was. It was established to their satisfaction, that a Genoese tartan, under Neapolitan colours, had arrived at Messina, after a passage of thirty days, from Missolongo, in the mouth of the gulf of Lepanto, opposite to Cephalonia. She brought wool, wheat, and some fine manufac- tures of the Levant. She had a clean bill of health, but had lost one of her crew on the voyage. The survivors were well. She had had no communication with any other vessel or port since she { xxxvi ) "sailed. And the Captain declared that the man had died of an ordinary dis- ease, caused by fatigue on a disastrous and tempestuous voyage. She was ad- mitted to quarantine; and while the wool was unloading, ihe Captain, ex- posed to the sickly atmosphere on shore, fell sick with an erysipelas of his face, and died on the third day. Two days af- ter, another man, who had been ashore, also became sick on his return to the tartan, and died with a swelling in the arm-pit, and petechias all over his body. " A consultation was held by the magistrates and physicians on the alarm occasioned by these accidents, and the tartan, and all her contents, except the men, ordered to be carried to a remote place and burned. Ail the other people continued well. " The full quarantine of forty days being performed, and Te Deum sung, ( xxxvii ) an alarm was given that, in another part of the city, a disease prevailed, accom- panied with buboes and other pestilen- tial symptoms. The physicians sent to examine the sick reported, that the distemper was nothing more than the epidemic which had prevailed since February. They grounded their opinion upon the fact, that it was not conta- gious, and did not spread from person to person. Therefore it could not be the plague, whose essential character, they said, it was to be in the highest degree contagious. Physicians, surgeons, con- fessors and barbers escaped it, though they attended the sick in hospitals. And the like immunity had happened in the malignant sickness at Bronte and Modica some time before. The distemper, how- ever, went on to increase with so much violence and mortality, that on the 4th of June it was allowed by all parties tq be the true plague. c ( xxxviii ) " The story of its introduction by the before-mentioned tartan, was not now deemed sufficient, in the judgment of the magistrates of Messina, to prove the introduction of the plague. They there- fore apprehended two sailors, belonging to another vessel, a suspected pink. By threats of torture, and the sight of the rack, a confession was extorted from them of the arrival of the pink at the port of Messina, after a coasting voyage to Modon, Patras, Missolongo, and other places. The contagion was brought on board in some rolls of tobacco, or bags of biscuit; and after having destroyed several persons belonging to the pink, was landed among the unfortunate Mes- sinians. Being completely satisfied with this forced story, which was modified by the engine of terror so as to answer every purpose they wished, they re- nounced the first one as erroneous and unnecessary. ( xxxix ) " The plague continued with but little abatement of its fury, notwithstanding the relics of St. Lucia and St. Bernard were sent to Messina from Syracuse to stop it, until the 2d of July, when the people took down from the great altar the ancient image of their tutelary saint, the Holy Mary, the mother of God, and carried it in procession through the streets. From that day the plague be- gan to decline, after numerous other processions had failed, and other saints been applied to in vain. " As soon as the sickness was declared to be the plague, the inhabitants were panic-struck. There were no bakers to prepare bread. There were no labourers to dig graves. There were no nurses to attend the sick. And as the distemper was deemed contagious, every person was afraid to touch another, and even to approach him. The people of the sur- rounding country refused to bring fuel ( xl ) or provisions to market, and guarded the roads leading out of town with so much strictness as to prevent the flight of the unhappy citizens into the country. The putrefying carcases of the dead lay scat- tered through the houses, heaped up in the streets, and piled in larger collec- tions at the church doors. These were so dangerous and shocking, that, at length, the furniture and wooden work of houses were carried into the streets for making fires to burn them. From these funeral piles fire was several times com- municated to the neighbouring build- ings. And by those direful consequences of the opinion entertained by the Franks, of the contagiousness and importation of the plague, the Messinians, instead of losing a few hundred persons, as they might have done by proper regulations, managed matters so badly as to destroy above forty thousand lives that season. The Turks judge more like rational ( xli ) creatures about this disease, and do not frighten, starve and poison themselves to death on account of it. " After the abatement of this calamity, so great a part of which was brought upon themselves by their own impru- dence, they concluded that a general purification was necessary to restore to health their city, contaminated by con- tagion. To superintend this grand ope- ration, the famous Dr. Polacco was sent for from Venice. And under his eye they went from house to house, and, after various washings, ventilations, and other processes, concluded by fumigat- ing with mixtures of pitch, brimstone, sal ammoniac, frankincense, storax, harts- horn shavings, raspings of pine, juniper- berries, dried rosemary, old leather, long pepper, camphor, gun-powder, orpiment, and antimony. And this ceremony be- ing over, the surviving inhabitants re- turned to their homes, as fully convinced c 2 ( xlii ) that the perfumery had destroyed the la- tent contagion, as that the image of the Virgin had stayed its ^active malignity. " Professor Thomas Fasano judged better on this subject. He published a book at Naples on the epidemic fever which desolated that city in 1764. It is entitled, Delia Febbre Epidemic a soffcrta in Napoli VAnno 1764. Libra iii. Di Tomasso Fasano. He is so wholly con- vinced of local and domestic origin, that he does not even mention any thing about a ship. And this, in a sea-port, is a very remarkable circumstance. Fasano, with great good sense, lays it down as a principle, that an epidemic is a slight plague, and that the plague is a powerful and furious epidemic, (che I'epidemia fosse un leggiera peste, e la peste un' epide- mia gagliarda e furiosa.) And, in like manner, MichaelSarcone, who wrote an history, in two volumes, of the dis- tempers which prevailed at Naples in ( xliii ) 1764, under the title of Istoria Raggio- nata de Mali osservati in Napoli nelV in- tero corso dell' Anno 1764, does not pre- tend that this epidemic was any thing else than a pestilence consequent upon the extreme scarcity and famine of the. preceding year. CONTENTS, Page;. Introduction 1 Meteorological observations, temperature, weight of the atmosphere, direction of the winds, and state of the sky during the year 7 (1798-9) at Cairo.....- 11 Observations on the diseases which attacked the army of the East in Egypt and in Syria, during the years 6 and 7 (4798-9) of the French Republic, contain- ing an investigation of its identity with the plague 13 Whether this disease be really contagious - 16 Of the symptoms accompanying this disease - 26 Of the causes which could have produced this disease in Egypt and Syria - - 35 Indications of cure _ ... 42 Treatment - - ib. Of buboes and gangrenes, known under the name of carbuncles or anthraxes - - 51 Of the means to be used for preventing the attacks of this disease 56 Of the means which might be employed in Egypt to destroy th« epidemic fevers 68 C xlvi ) Page. Of the seclusion of the Franks during the time of the plague - 73 Of lazarettoes and quarantines - 7d Reflections on the epidemic fever observed in the Ligurian Republic, and in the hospitals of the army of Italy, in the year 8 (1799 1800) - 89 Reflections on the yellow fever which appeared at Cadiz in the year 1800 - 93 Symptoms - 94 Causes ... - 95 Method of cure - - . - - 97 Means of prevention - 100 Queries respecting the yellow fever which appeared at Cadiz in the year 1800 - - 101 On the dysentery ... 104 Treatment, and means of preventing this disorder 108 On the ophthalmy of Egypt - - 116 Description of the ball of the eye - - 117 Description of the ophthalmy - - 123 Causes - - 125 Indications - - - _ 132 General treatment of the ophthalmy - 133 Treatment of the simple ophthalmy - - 136 Ti-eatment of the complicated ophthalmy - 139 The treatment used by the Egyptians for the cure of the ophthalmy - 145 Powders, ointments, and collyriums used in Egypt in the treatment of the ophthalmy - 148 On the means of preventing the ophthahTiy - 150 Description and plan of an hospital for soldiers attacked in Egypt with the disease called the plague, &c. - 15a ( xlvii ) Page, Report made to the Society of the School of Medi- cine at Paris .... 176 Report made to the Consuls of the French Republic, by the Minister of War, the 15 Germinal, year 9 (4th April, 1801) 196 Additional Notes .- - 199 Appendix. Concerning the Seasoning, or Yellow Fever of the West-indies - •. 2lt INTRODUCTION. HAVING been appointed to attend the grand park, of artillery during the expedi- tion to Syria, in the rank of medical officer, I arrived at Jaffa on the 15th Ventose, in the year 7 (the 6th March, 1799), and on the 18th (9th), I took the charge of the hospitals in that city. Forty days afterwards I received order? to follow into Egypt General Damas, and several other soldiers, who had been se- verely wounded ; the unhealthiness of the country and other circumstances requiring that measure. On our return to Damietta the citizens who composed the board of health there considering us to he affected with the plague, put us under strict qua- rantine. To beguile the ennui of my prison, I resolved to commit to writing (although B ( 2 ) in a foreign language) the observations which I had made on the disease which was the cause of otir seclusion.. I employed my- self successively in this not even if I had been ( 57 ) surrounded by the whole guard of health fgarde sanitaire). As I was persuaded that obstructed perspiration, damp and in- fected air, the exhalations of marshes, and bad food, were the principal causes of this disease, I endeavoured to avoid unhealthy places, damp and cold air, and made use of the best food I could procure; and as I knew the influence of the affections of the mind in predisposing to disease, I avoided all melancholy ideas, by being always em- ployed. When I went to the hospital, I always- endeavoured to arrive there without being in a perspiration; and before entering the wards, I took, in the apothecary's shop, a large cup of the bitter coffee. During my visit, I held in my hand a citron stuck full of cloves, without attributing to it any great importance. After paying my visit, I took a walk, or got on horseback; and although not of a constitution to perspire easily, I never returned without being in a sweat. Before going to bed, I took a glass of punch, or spirituous lemonade^ ( 58 j made very hot; after which I lay down^. covering myself well up. During the night I never failed to perspire considerably* These were the only precautions which I took to preserve myself from the disease of Jaffa. During all the epidemic fevers, and even the most dreadfuf-pfagues, there have been in those cities and provinces, where these diseases were raging, some healthy spots. The citadel of Cairo presents one example* It has been observed, that the inhabitants of this fort and its environs have always es- caped from the plague, even from that of the year 1791. If the inhabitants of this fort, in spite of their daily intercourse with those of the city, were preserved from this disease, it must be because the damp and infected air which had destroyed the health of the inhabitants of Lower Cairo, had not sufficient elevation to reach to the highest part of the citadel and its environs, and consequently could not impair the health of those who lived there. At the time when I was doing, duty ia 1 59 1 the military hospital of this fort, I have often seen, at the rising and setting of the sun, the whole city enveloped in a mist so thick, that it was impossible to distinguish even one of the innumerable minarets of this immense metropolis, although the fort was then enlightened by the rays of the sun, and the air which we there breathed was elastic, pure, and light. In 1764, an epidemic fever showed itself in the kingdom of Naples, and, conjoined with famine, made such immense havock, that two hundred thousand persons pe- rished. Negligence and terror had with- drawn from the sick, scattered here and there over the city, all kind of assistance; a circumstance which became the principal cause of the progress of this disease. Ex- perience having shown that the sick remov- ed to the sea shore recovered, a number of hospitals and lazarettoes were esta- blished there. It was observed that the nurses, and those employed in the hospitals, didmot contract the disease, in spite of the contagion. The principal remedies which ( 60 1 were employed at this epoch were iced water, the bark, musk, and the vegetable and mineral acids in large doses. I can recommend nothing more useful and efficacious in such cases, than to re* move from those places where these epi- demics prevail, and to choose a place where the air is more healthy. With respect to soldiers, every time that a disease threatens to spread itself amongst them, a circum- stance very common in Lower Egypt dur- ing the unhealthy season, it is very import- ant to remove the camp to a healthier situ- ation, and to have the garrisons relieved by troops coming from healthy quarters, and then send the former to places where the disease has not been. There they lose the predisposition which they had to contract the disease, while the troops which shall have relieved the garrisons will not contract it so easily, because they will not have that predisposition; and every time that the health of these new troops shall become impaired, they ought, without delaying on any pretext, to be relieved in their turn, ( 61 ) even if it should be by those who were there before. In order to prevent all sus- picion, and avoid all danger of carrying the disease where it has not been before, they should take nothing with them but their necessaries; they should avoid as much as possible halting in villages; and each time when they happen to encamp, they should expose their baggage and cldthes to the air, which would not fail of dispers- ing every principle of contagion, and set- ting at ease the minds of those who are timorous. By thus changing successively the garrisons, we should preserve in good health a whole army, even in places the most infected. When the rains shall have ceased, the heats of summer returned, and the marshes have dried up; in a word, when the season shall have changed, and every place become equally healthy, we may then leave off these useful yet trouble- some marches and countermarches. During the expedition to Syria, the °-e- neral of division Dugas, commandant of Cairo and Lower Egypt, being informed G ( 62 ) that the plague existed amongst the garrison of Fort Birketalagi, immediately stopt its progress, by sending the garrison to Cuba; there the soldiers, respiring a pure and wholesome air, recovered their health in a few days, and the troops just arrived at Birketalagi, preserved themselves in good health, the more easily, by paying a proper attention to cleanliness. This prudent Ge- neral had before observed, at Damietta, the advantages resulting from this measure, as the following letters, which he wrrote to General Bonaparte, the 17th and 24th Ni- vose, 8th year (8th and 15th March, 1800),. bear testimony, " Damietta, 17 Nivose (%th March). " The second demi-brigade of light in- fantry is affected with the prevailing ma- lady, more particularly than the others: this same regiment was also severely attacked at Menzaleh with another fever, which obliged more than two hundred men to .enter the hospital. A battal.on of the 65th ( 63 ) Went to relieve them; they have inhabited the same barracks, and occupied the same posts, during twenty-five days, and have not had a single sick man. Only one officer has had the prevailing fever, and he has recovered. I am convinced that this dis- ease takes its origin from the bitter cold- ness of the nights, and that it is the conse- quence of checked perspiration, a cause which, acting on several individuals at the same time, gives to the disease a contagious appearance, which vanishes on a closer examination." In his letter of the 24th (15th March), he proposes to send to Mansoura the com- panies of the second demi-brigade for change of air, the quarters which they oc- cupied at Damietta being unwholesome, and their spirits dejected by a prepossession which it was necessary to do away. As soon as the second demi-brigade was on its march for Syria, forming part of the division Kleber, it became perfectly healthy; whereas at Damietta, it had furnished five sixths of the sick in the hospital. ( 64 ) I have also remarked, that it is even use- ful for the troops to march from one place to another, although both quarters happen to be equally infected. How often have I not seen soldiers who, on seeing their com- rades dying, fled from Gaza, although they themselves had the fever and buboes! These patients, at the time of their leaving the hospital, were scarcely able to hold themselves upright; but, after having got some leagues into the desert, their strength returned, and they arrived at Jaffa in better health. After having rested themselves some days, I advised them to continue their route to- wards Acre, in order to give rise to a greater change in their physical and moral constiu> tion. It was thus that Citizen Marillac, officer of artillery, recovered, who was not able to get well in Jaffa: he was become so feeble, so meagre, and so much disfigured, that his friends could hardly recognise him, In this state of debility he endeavoured to travel to the camp at Acre. Having ar- rived there, he received orders to return to C 65 ) jfaffa, with some troops appointed to take charge of a convoy of ammunition, and pieces of artillery. In a little time he re- gained his good plight and former colour. Change of place and air, in diseases of de- bility, and particularly in epidemics, has been found useful at all times; and, I will even add, however severe the symptoms, however advanced the disease, or weak the patient may have been. This is so true, that I have actually seen men recover, who had not, to all appearance, two hours to live. Of this fact, those who assisted at the evacuation of the hospitals in Syria were witnesses. It would be impossible to conceive the importance, or appreciate the advantages resulting from this measure, if one had not had the means of judging of it by experience. Whilst the disease was making the greatest progress at Alexandria and Rosetta, the soldiers of the naval legion escorted, for a long while, the caravans which went by land. They all enjoyed the best health during this active service;, but scarcely had they become stationary at G2 ( 66 ) Rosetta, when more than two thirds fell sick. This fact is well known, and parti- cularly by General Martinet, who then commanded that legion. I am persuaded, that if those men had, instead of remain- ing at Rosetta, crossed the desert to go to Cairo, or elsewhere, they would all have been preserved from the disease. The Be- douin Arabs, wandering in the deserts, are never attacked, notwithstanding their com- munication with the infected cities, during the time of their most dreadful plagues. How many individuals, on the return of the army of Syria to Egypt, recovered their health in the desert, even at the distance of a few leagues from Acre, from Kaiffa, from Jaffa, and from Gaza! If they had remained a few days longer in these cities, they would, in all probability, have fallen victims to the disease.* * General Damas, severely wounded in the mountains of Mont Tabor, by a ball which had broken the humerus near its articulation with the fore arm, was removed to Jaffa, and lodged in the house of the fathers of the Holy Land. The accidents following upon this wound were very severe, and se- veral times endangered the loss not only of the arm, but the life of the patient. This General, during the times of dresa- ( 67 ) It is a fact, that some of our sick soldiers in Syria, on seeing the departure of the army for Egypt, endeavoured to follow it on foot; and although from their debility* they fell several times on the ground, they got up again, and contrived to follow the columns until their arrival in Egypt, where they recovered their health. Citizen Mechaud, chief of a battalion of engineers, communicated to me the follow- ing fact, which happened whilst he cora- > manded at Katie. Some soldiers, on their return from Gaza with a convoy, discovered at a distance a French soldier wandering ing his wound, was supported by his valet de chambre, who, without any bad design, kept concealed a pestilential bubo-, which he then had, and continued in that state for two days to wait upon his master. There was at the same time in the house four persons attacked with the plague, two of .whom died, which made General Damas determine to dismiss his ser- vant, and change his lodging. I had him removed to the most elevated part of the castle of Jaffa, in order to avoid the damp air as much as possible. In spite of this, his wounds, which had before showed every appearance of healing, shortly took on a bad aspect, and I observed him from day to day contract- ing the predisposition to the disease. The fear of seeing him die of the plague determined me to advise him to quit Jaffa. From the second day of his being at sea, all the symptoms of the plague disappeared, and his arm healed: he can now make use of it as well as formerly. He has since been nominated general of division, and chief of the etat major general, and performed the glorious campaigns of the year 8 against the army of the Grand Vizier. ( 68 } amongst the sands, about two leagues from the fort; they went up to him, and found him with a bundle of sorrel under his arm: .this man had been attacked with the epi- demic disease, and during his delirium, had run off from the hospital. During the fif- teen days which followed, he had taken no other nourishment but sorrel, and he reco- vered perfectly. I have seen this plant in several places in the desert, its leaves scarcely raised above the sand: on pulling it up by the roots, it presents a weak means of diminishing the burning thirst of the traveller.. Of the means ivhich might be employed w Egypt to destroy the epidemic fevers. Before speaking of the means which might contribute to render Lower Egypt as healthy as the finest countries of Europe, it will not be useless to premise some to- pographic medical notions of Alexandria; Rosetta, and Damietta; in which cities every year epidemic fevers break out, f 63 ) Alexandria is a city celebrated in ancient history, situated at 31° 13' 5" northern la- titude, and at 27° 35' of longitude from the meridian of Paris. It is washed by the sea on the west and the north, and on the east and south are situated the lakes Ma>- reotis and Madiez. Rosetta is situated at 28° 8' 30" of longitude from the meridian of Paris, and at 31° 25' 20" of northern latitude. It lies about two leagues from the sea, upon the left bank of the Nile: to the eastward, on the other side of the Nile, there are a great number of flat grounds, which, after the inundation of the river, form very numerous and extensive marshes. Damietta, the third celebrated city on the coast of Egypt, on the eastern bank of the phatnitic branch of the Nile, lying in 29° 29' 15" of longitude from the meridian of Paris, and 31° 25' 43" of northern lati- tude, has the sea and the lake Menzaleh to the north, and is divided by the Nile. The fields of rice which surround this city contribute to infect the air; besides, there are several lakes, pools, and marshes in its ( TO ) environs, which render it very unhealthy; Senanieh, among others, is a village remark- able for its insalubrity. The heavy rains which fall during the winter at Damietta, at Rosetta, and Alex- andria, contribute greatly to produce dis- eases, which the sonth winds, the fogs, and exhalations of the marshes render more dan- gerous. It is asserted, that these diseases are more frequent when the inundations of the Nile are high, and of long duration. The inundation of the year 6 (1798) was ©ne of the most considerable; notwithstand- ing which the disease did not show itself but in those cities on the coast of the Me- diterranean. The other cities of the Delta, Boulac, Cairo, Gizeh, and the whole of Upper Egypt, were preserved from it. In the fort of Birket-El-Agi alone, a few deaths hap- pened from a suspicious disease, which, in my opinion, without having recourse to contagion, were occasioned by the evapo- ration of the stagnant waters of the Lake af the Pilgrims, so called on account of the ( 71 ) meeting together, at this spot, of the grand caravan, which every year sets off from Cairo for Mecca. The putrefaction of the aqua- tic plants, and of the immense quantities of fish in this, lake, contribute to its develope- ment. In the ancient histories of Egypt, there is no mention made of the plague. The former inhabitants of this celebrated coun- try either did not distinguish this disease from others, or were unacquainted with it. It is certain that Alexandria, Rosetta, and Damietta, as, well as the whole surface of Lower Egypt, are so much changed, that formerly these places might have been the most healthy parts of Africa. The ruins of entire cities, destroyed and overwhelmed; the majestic remains of ancient monuments, preserved in spite of the overthrowing ac- tion of time, which at this day are in part submerged and surrounded by water, are sufficient to prove the revolutions which this part of the globe has undergone. The profound and interesting researches made by General Andreossi, and by the respect- ( W ) able body of philosophical men and mem- bers of the French Institute in Egypt, are worthy of examination: they are preserved in the Egyptian decade. At this day the lakes, the marshes, and the filthiness which one finds in the cities of Lower Egypt, are the principal causes of the frequent diseases to which they are subject, and which can never be eradicated until we have found means to purify the atmosphere of their environs. This import- ant advantage may be obtained by draining off the waters of the lakes, and filling them up; by keeping the cities clean, paving them, and giving a free exit to the rain water, which, stagnating in different parts of the cities, becomes corrupted, and, con- joined with filths, infects the atmosphere. By similar operations, several cities and provinces in Europe, Amerca, and the In- dies, have been rendered healthy. I have no doubt that the salubrity which we at this •day enjoy in France and Italy, is the result of the amelioration of agriculture, and the perfection of the arts. ( 73 ) Of the Seclusion of the Franks during the time of the Plague. When the Franks residing in Egypt are assured that the plague has broken out in the place where they live, they retire into their houses, shutting all their doors, and having no intercourse with any one until the 23d of June, the eve of St. John. Not only are their doors closely shut, but they block up with care even the smallest holes, in order to prevent any animal entering their dwelling; and if by chance a cat should creep in, they immediately pursue and kill it. For this purpose they have loaded mus- kets always in readiness, and springs set in the suspected parts of the house. The cats of the family are shut up in cages, like fowls; and if, unfortunately for them, they chance to leave their prison, and make their escape, on their return they are killed with- out mercy, according to the sanitary lazvsi in case they should, during their absence, have contracted the poison of the plague, H ( 74 ) and brought it home attached to their tail, or hair of their skin. In the lower court, or near to the gate of the house, they place three large earthen vases filled with water, a bason with vinegar, a furnace with coal, some odoriferous herbs, antipestilential powder and pastes,iron pincers, a large knife or stiletto, and some other utensils used for destroying the poison of the plague. Each family has a Turkish domestic, who is not comprised in the shutting up, and who is employed to transact all commissions: this man comes every morning to his master's house with the necessary provisions, which he hasbought at market. The porter, who is generally the steadiest person in the family, and the most strict observer of the sanitary laws, after having reconnoitred the domes- tic, descends with the key in his hand, opens the door, and retires to the top of the stair- case, in order to avoid all risk of contagion from the servant, who, entering into the court, puts the provisions, such as meat, fish, herbs, and fruit, into the vases full of water. If he has money, he puts that into ( 75 ) the vinegar; if papers of importance, such, as bills of exchange, invoices, &c. he puts these near the furnace; and after he has heard from a distance the porter give him his orders for the following day, he with- draws. The porter follows, and shuts the gate of the house: then, after having taken in his hand a kind of magic ring, he stirs about in the water the meat, the fish, and the herbs, in order to drown and destroy the pestilential poison. He then takes the mo- ney out of the bason of vinegar, and, hav- ing lighted the coals, he throws on them some powders and perfumes: afterwards, with the pincers, he takes the papers, and places them over the furnace, where they remain at least for two hours in the smoke; by this method, in their opinion, they are freed from all poison, and may then be touched without communicating the plague. They likewise purify sealed letters, and other papers, by piercing them with the stiletto in two or three places, and dipping them in the vinegar. The linen and other clothes washed out of the house may be admitted ( 76 ) without any risk, provided they be still wet. The bread prepared in the house, and sent to the oven to be baked, may be received without any precaution, provided it has never been touched as long as it was hot. Tobacco, pulse, sugar, coffee, and every thing which, in the lazarettoes, is called a substance not contaminating (substance non contumace), may be admitted without pre- caution into the insulated houses. The con- taminated substances are absolutely ba- nished the house till the 23d of June, the day when all danger of the plague ceases, whatever may have been its violence. The inhabitants of the Levant have a general belief that the eve of St. John puts a limit to the plague; and at this epoch they leave their cloisters,embracing andcongratulating each other on having escaped the scourge. Of Lazarettoes and Quarantines. Lazarettoes are large buildings situated commonly on the sea beach, at a little dis- tance from the harbours, consisting of lodg- ( 77 ) ings, hospitals, magazines, and very exten- sive enclosures, and including a portion of the roadstead, or harbour, capable of con- taining a certain number of vessels. These lazarettoes are destined to receive and retain, for a limited time, passengers and ships' crews, merchandise and vessels coming from places where the plague is rag- ing, so that they may have no intercourse with any one whatever, till the termination of the quarantine. Quarantines are divided into quarantines of rigour, and those of observation. Qua- rantines of observation never exceed fifteen days, and are neyer less than five: quaran- tines of rigour consist of thirty-nine days, or forty, computing from the day of com- mencing. Such vessels as come either from the coast of Africa, in the Mediterranean, or from any sea-port town in the Levant, are put under quarantine; that is to say, they sail into that part of the roadstead, or harbour, which is appropriated to the lazaretto; after which the captain of the vessel presents H2 C 78 ) to the board of health (bureau sanitairej his certificate of health, in which are spe- cified his destination, the day of his depar- ture, the names of himself and his vessel, the cargo, the number of his crew and passengers, and whether, in the place from whence he came, there were any instances of the plague. This certificate is taken through a grating by means of a pair of long pincers, and is not read until it has been thoroughly perfumed and dipped in vinegar. If the certificate gives notice of the plague, the vessel is considered foul (brute) ; if on the contrary, it states that, for some time past, there has not been an instance of the plague in the place from whence she sailed, she is considered clean (nette)s if it was only a short time since the plague had ceased, she is considered suspected (sus- pecte). In the first case, the passengers and ship's crew are strictly reviewed at a dis- tance; and although every one of them should enjoy perfect health, they are all placed under a quarantine of rigour. When the certificate is clean, the quarantine lasts ( 79 ) a shorter time; and in the third and last case, it is a quarantine of observation, which lasts a longer or shorter time, according to the decision of the conservators of health. If any vessel, before entering the harbour, has been visited by a vessel from the coast of Africa, or from a sea-port in the Levant, or belonging to an enemy, she is placed under strict quarantine, even if she had come from the nearest port; as, according to the sanitary laws, her certificate is considered foul (brute). When merchandise is put under quaran- tine, it is deposited within the enclosure, or in the magazines appopriated for that purpose. The establishment for this end, at Marseilles, is very beautiful, of prodi- gious extent, and shows the importance of the commerce which France carries on with the Levant. The passengers are put on shore, and sent into the enclosure with one or more guards of the committee of health fcomite sanitaire), while the ship's crew re-» main on board, with some others. The por- ters, and those persons employed to purify ( 80 ) the merchandise, in order to ascertain whe- ther or not the bales of wool and cotton con- tain the vapour of the plague, open them in the middle, and thrust in their bare arms, believing that, if they contained the plague, the disease would without fail show itself on them. They break open the chests and trunks, and expose to the air the bales of flax and of silk, the cloths, sails, stuffs, and, in short, every article on board. They pre- tend in this way to facilitate the evapora- tion of the pestilential fomes, which per- chance might have been brought in along with the merchandise. At length, after having exposed every thing day and night to the air for the space of thirty-nine days (serene) ; after having, in the course of the quarantine, perfumed the passengers, the ship's crew, and the vessel, three times, they permit them to enter the harbour. If, during the time of the quarantine, any one falls sick and dies, should the cause of his death be suspected, the quarantine is prolonged, and sometimes it recommences, and this every time such an accident happens. ( 81 ) When the death of several persons on board puts out of doubt the existence of the plague, and that it is making progress in- stead of diminishing, the laws of health condemn the vessel, without any reserve, to the flames. Those who compose the crew, after being stripped of all their clothes, and having their whole bodies shaved and washed in sea-water, are admitted into the lazaretto, in order to undergo there a rigor- ous quarantine. The vessel, with its mer- chandise, is towed out to sea, where it is either sunk or committed to the flames. If the porters employed to purify the merchan- dise are attacked with the plague during the quarantine, or some days after that ope- ration, the committee of health pronounce the goods infected, and, without delay, cause them to be burnt or sunk. It has often been said, that in breaking open a letter, or in opening a bale of cotton containing the germ of the plague, men have been struck down and killed by the pestilential vapour. I have never been able to meet with a single eye-witness of this ( 82 ) fact, notwithstanding the inquiries which I have made in the lazarettoes of Marseilles, of Toulon, of Genoa, Spezia, Leghorn, Malta, and in the Levant. All agree in repeating, that they have heard of such an occurrence, but that they have never seen it happen. Among those whom I have interrogated about this fact, I may name Citizen Martin, captain of the lazaretto of Marseilles, who, for thirty years past, has held that situation: this brave and respect- able man told me, that during that time he had seen opened and emptied some millions of bales of cotton, silk, furs, feathers, and other goods, coming from several places where the plague raged, without having ever seen a single accident of the kind. Observation, necessity, and experience have taught that all substances which are necessary to life, are not equally susceptible of imbibing the pestilential poison; that there are even some which are not suscep- tible of contracting it, and which conse- quently cannot communicate the plague. The substances liable to communicate ( 83 ) the plague are called contaminating, while those which cannot imbibe this poison, are called non-contaminating. I think we may distinguish three classes of contaminating substances. For example, wool, cotton, silk, hemp, stuffs, hides, all kinds of hairy skins and furs, are contami- nating substances of the first class. These substances do not lose their infectious qua- lities until after forty days exposure to the air (serhie). There are goods which, in order to pu- rify from the poison of the plague, it is suf- ficient to put in vinegar, or in perfumes; such are papers, as well as samples of stuffs, &c. which I rank in the second class. Gold, silver, and all the other metals, porcelain, delft-ware, and glass, although they are non-contaminating substances, may contain some foreign body, charged with pestilential poison, if they have been hand- led by infected persons; and they ought to be put in water, as well as fresh fish, meat, herbs, fruits, and all kinds of animals hav- ing hairy skins. I consider these substances ( 84 ) as contaminating of the third class; fresh, or sea-water being perfectly sufficient to de- stroy any of their contagious properties. Wax-cloth and stuffs, when they are wet, do not communicate the plague. Every kind of wood, straw, hay, flowers, osiers, mats, provided no hempen nor cotton threads enter into their texture, wax lights and candles, provided the wick be burnt to the level of the wax or tallow, ivory, mother of pearl, wheat, seeds, tobacco, coffee, sugar, pepper, and aromatics, salt, oil, and liquors, are not liable to imbide nor to communicate the plague. These principles being established, the officers of health prolong, abridge, or mo- dify the quarantine, delivering or detaining for a longer or shorter time the persons and goods in the lazarettoes. It follows from these principles, acknow- ledged by the officers of health, that you may inhabit the same house, the same ves- sel, the same chamber, walk together, sleep upon the same beds, or the same mats, and keep company with persons under qua- ( 85 ) rantine, even whilst they are attacked with the plague, provided you do not touch them neither directly nor indirectly. You may take snuff offered by a person having the plague, provided the box be of wood or of shell. There is no danger even in breaking bread with them, provided the bread be cold; for if it were warm, it might communicate the plague. How then is the reason of all this to be explained? Those who wish to have the fullest details upon lazarettoes, quarantines, the manner of pu- rifying contaminating substances, and to acquire the fullest ideas on the subject of the plague, should consult the codes of health at Marseilles, at Toulon, and at Ve- nice. They will also find, in a work of J. P. Papon, ci-devant historiographer of Provence, printed at Paris in 1800, the memorable epochs of the plague, from 1491 before the birth of Christ, till that of Marseilles in 1721 of the Christian sera. They will there learn the means which are proposed for preventing this disease, upon the frontiers of a country which it is ravage I ( 86 ) ing, as well as the precautions to be adopted in cities having the plague. There is also a good deal said ofthe purification of goods, of houses, of preservatives, of lazarettoes, of the police of sea-ports, &c. Had I not predetermined to state nothing but the ob- servations made by myself in Egypt and Syria, I should have added a few reflections on the work of this author. I, however, reserve them till a future occasion, when I mean to analyse this disease more at length. On an unprejudiced examination of the works of writers on the plague,' we find nothing but frightful recitals of what hap- pened in the epidemics which they have described. They alHnsist on the necessity of quarantines, and forbid the inhabitants, under pain of death, to quit their houses, whenever there has happened any death by the plague; believing that this means will suffice in stopping its progress. It is not difficult to conceive that the shutting up together of several people in good health, .and some sick, and obliging them to breathe the same air, which every day becomes more C 87 ) and more infected, must augment the dis- ease of those who are already sick, and ex- pose the others to contract it. Experience has proved that these seclusions, or shuttings up (renfermemens), have never succeeded in arresting the progress of the plague. This disease always commences by attack- ing the poor in the most unwholesome quarters of the city; after which the health of the inhabitants in good circumstances be- comes impaired, and at length death levels indiscriminately the poor and the rich. Then, all becomes confusion in the city: the magis- trates are no longer able to maintain their authority, the shuttings up cease by little and little, the season changes, the atmosphere becomes purified, those who have escaped recover strength and courage, and all at once the epidemic ceases. This is what has been observed in all plagues, but par- ticularly in that of Marseilles, in 1721, The history of these epidemics strikes one with horror; and, after comparing them with the most malignant plagues of the Le- vant, where the shuttings up are only in use amongst a very small number of individuals, ( 88 ) I have no hesitation in declaring, that in Europe the mortality has been the greatest. It is generally thought that the principles of fatalism of the Turks contribute greatly to increase the propagation of this disease amongst them, because they will not make use of any precautions. This much how- ever is certain, that the Mussulmen, during the plague, attend on their sick with parti- cular care even to the last moment of their lives; whilst, on the contrary, our sick are separated from the rest of the family, and abandoned to their unfortunate lot, the mother even refusing to carry assistance to her own son during the agonies of death, and the husband not daring to approach the dearest object of his affections, who re- quests from him a drop of water in a voice the most tender and supplicating. A like inhumanity has place neither in Asia nor in Africa; and if I were doomed to be at- tacked by the plague, I should by far pre- fer being in the hands of the Turks, than in those of the Europeans. Si quid novisti rectius istis, Candidus imperti; si non his utere mecunv ( 89 ) REFLECTIONS THE EPIDEMIC FEVER Observed in the Ligurian Republic, and in the Hospitals of the Army of Italy, in the Year 8 (1799-1800). 1 HE analogy and affinity which all epi- demic fevers bear to each other; the facility with which an alarm is propagated as soon as one of these dreadful diseases discovers itself in any city or province, has induced me to state here my opinions upon a pecu- liar epidemic fever, which alarmed the in- habitants of the environs of Montpellier, during the first months of the year 8 (1799- 1800). See the Journal de Medecin, page 373. An epidemic disease spread its ravages m the hospitals of the army of Italy3 and carried off daily its numerous victims. Fly- ing report, which always magnifies every 12 ( 90 ) danger, and attenuates every good, spoke of nothing but the number of deaths: al- ready even the name of the pestilential dis- ease spread dismay far and wide. In this alarming situation, the public authority thought proper to consult the school of me- dicine of Montpellier, which hastened to calm their inquietude, and reanimate their spirits, by proving that this fever, falsely regarded as pestilential, was not at all dif- ferent from the fever of hospitals, the typhus carcerum of Pringle, or the fever of camps and armies, febris castrensis : and, as a mode of preservation, they recommended a generous strengthening regimen, great cleanliness, pure and frequently renovated air, and a state of mind exempt from fear and inquie- tude. On my return from Egypt to France, I arrived in the gulf of Jouan the 25th Prai- rial of the year 8 (14th June, 1800), and I collected the particulars of the epidemic which had just carried off a great number of the inhabitants, and of the soldiers in the environs. It was the same as that which { .91 } we have just been describing; and it was observed during this epidemic, that the in- habitants residing near the sea were more exposed than those who were at some dis- tance ; and that there were several villages situated on the heights, which had not even a single sick person. With regard to this disease, the majority attributed it to the rains and the fogs. A citizen of the environs of Antibes assured me, that if this disease had taken place some months before, it would, without fail, have been attributed to the vessels just ar- rived from Egypt, and which had put ashore at Frejus without performing quarantine. A similar epidemic, probably the same, showed itself in the hospitals of Genoa some months after; and it was stated in the pub- lic papers, that a physician of that city had refused to go and take charge of the sick of the hospital, for fear of the contagion. I am led to think that this citizen was read- ing at the time the work of M. Papon, in which are related the particulars of the plague of Marseilles. If I were to give ( 92 ) advice to medical officers employed in treat?- ing epidemic diseases, it would be to banish melancholy and fear, to live well, and avoid all excess; and if they are fond of readings to choose amusing books in preference to- those which treat of the plague. { 93 ) , REFLECTIONS on THE YELLOW FEVER OF CADIZ In the Year 1800. AN treating of the disease of Egypt, known by the name of the plague, and of the epi- demic fever, observed during the year 8 (1800), in the bay of Genoa, at Nice, and at Montpellier, we have seen with what facility we are deceived with regard to the nature and causes of these diseases. When a dreadful epidemic breaks out in any city or province, we, without fail, have recourse to some peculiar poison, imported from dis- tant countries. Hence, some have made the yellow fever come from Palestine, and others from the West-Indies. Amongst the authors who have written on this disease, some say that it spreads it- self by contagion ; others, that this happens ( 94 ) but rarely. (See Hillary's Description of the Yellow Fever which prevailed at Bar- badoes.) There are even some physicians who maintain that it is no wise contagious. In the Journal de Medecin, of Paris,in the year 9 (1801), Citizen Halle, professor of the school of medicine, has given us the history of the yellow fever of Cadiz. As we have been treating of an epidemic which may have some affinity with other diseases of this nature, I may just be permitted to mention here its principal features, and to add some reflections and queries, which may perhaps tend to procure us some more distinct ideas of this disease. Symptoms. From the 10th to the 15th of August, in the year 1800, there broke out in the quar- ter of St. Mary, at Cadiz, a fever, which, in the end, ravaged this city, in a short time: it had the character of a slow nervous fe- ver. In the supplement of the Gazette of Madrid, we read, that some corsairs and ( 95 ) sailors, consisting both of strangers and na- tives, brought this disease into a single fa- mily in this populous part of the town, and that from thence it communicated itself to all those who had any intercourse with them, and afterwards spread itself to all the other quarters, attacking indiscriminately all classes of the inhabitants of this city. •Causes. With regard to the cause of this disease, the author of the Journal de Medecin thinks that it certainly was not caused by the im- portation of any contagion. He thinks^ with reason, that fear and terror, and the long-continued heats of a burning summer, preceded by heavy rains, and followed by a very warm easterly wind, which lasted forty days, and which made the thermome- ter of Fahrenheit mount to 85 degrees, might, in the end, have facilitated and ren- dered more rapid the course of this disease, called the yellow fever on account of the yellowness which supervened. It began ( 96 ) by shiverings, accompanied by general un- easiness, and a bilious vomiting of a yellow or green colour, stools of the same nature, loss of strength, quick pulse, burning skin, heavy pains in the head, temples and or- bits, pains in the loins, the bones, and su- perior orifice of the stomach. If these symptoms continued increasing until the fourth or fifth day, the patient was in jeo- pardy : the yellowness supervened, accom- panied by subsultus tendinum, petechias, and hiccough; the vomitings and stools be- came bloody, blackish, and foetid; the ex- tremities cold; and all the symptoms of putridity appeared. If, on the contrary, the sick felt some relief on the first days of the disease, there was then reason to look for their recovery: the yellowness, haemorrha- ges from the nose or the fundament, were not bad symptoms, provided vomiting or hiccough did not supervene. Some pati- ents were observed to have phlyctense, and swellings of the parotids; and others had phlegmonous tumours, which were termi- nated by gangrene. t 97 ) 'The dissections of several dead bodies showed bilious collections in the liver, the gall bladder distended, the gall ducts ob- structed, and in general an erysipelatous inflammation of the abdominal viscera, and very frequently gangrene of the intestines and stomach. Method of cure. Several patients, who were slightly at- tacked, were cured by a little of the ack dulous tartrite of pot-ash, some decoction of bark, slight sudorifics, lemonade, and nitrous drinks, not omitting glysters, and some gentle laxatives. In the more severe attacks, vomits on the first day of the dis- ease were employed ;* the second day bark was administered, in order to prevent the exacerbation on the third; whey, with a little syrup of borax, or nitrous aether, was * Citizen Halle has with reason remarked, that almost all those who have seen the yellow fever in the West-Indies, have dreaded emetics, as augmenting the irritation in the stomach, exciting vomitings which could not be stopt, and hastening the gangrene of this viscus. (See Roupp, Bruce, Lind, Hi) fary, &c.) K ( 9* ') added to the tisans, and advantage was de- rived from glysters of decoction of tama- rinds, or decoction of bark. In order to moderate the vomiting, and calm the hic- cough, they gave camphor emulsion in large doses: emulsion, with lemon juice in par- ticular, was most successful in stopping the hiccough. In the haemorrhages they made use of the sulphuric acid, sufficiently diluted, but in repeated doses. Blisters produced the best effects during the comatose state.* In those cases where, with the yellow- ness, a bilious diarrhoea came on, they ad- ministered a laxative tisan made from ta- marinds. If the evacuations were accom- panied with fainting fits, they gave the pa- tient a few spoonfuls of a cordial mixture, with some vitriolic aether mixed with water of linden tree flowers; the burning heat in the intestines was moderated by emollient, oily, and anodyne glysters. In the worst cases they employed the decoction of bark * Hillary says, that blisters, so far from being useful, aug- mented the comatose affection, the trembling, subsultus tendt- num, colduecs of the extremitie-s, and haemorrhage. C 9'9\ ) with vitriolic aether, opium, the liquor ano^ dynus, &c. Sometimes a violent fever showed itself, followed by fits of intermis- sion ; and although the bark prevented the attack on the following day, the patient was destroyed in a very short time. This circumstance recals to my mind a case nearly of the same kind, which occurred to me whilst I was physician and surgeon in chief of the Duke. of Modena's body guards. M. Volpi, a young man belonging to the corps, of a very robust habit, not being able to void his water, endeavoured to in- troduce into the urethra some thick violin string, which irritated the prostate and pas- sage to such a degree, that a considerable swelling of the yard followed, accompa- nied with inflammation. The case was so severe, that I called in consultation one of the physicians of the city, who considered the patient to be attacked with an intermit- tent fever, and persuaded him to take bark in large doses, in order to stop the double tertian, which was merely symptomatic, arising from the inflammation of the uri- ( 100 ) nary passages, and followed exactly the course of a true fever of suppuration. The physician gave himself credit on seeing the patient free from fever, but the gangrene made such a rapid progress that death fol- lowed when we believed him out of dan- ger. It is clearly to be perceived, that bark was not the most appropriate remedy in such a case, and that its tonic action only augmented the disorder, particularly as it was administered at a period of the disease when the irritation and state of the patient required emollients and refrigerants. It appears evident to me, that the yellow fever of Cadiz, in spite of its resemblance to the slow nervous fever, had at times the inflammatory character; and it is not sur- prising that the bark then hastened the gan- grene, by augmenting the inflammation. Means of prevention. At the breaking out of the disease at Ca- diz, the common sewers were ordered to be cleansed, and the dead bodies buried with- ( 101 ) out the city. An hospital also was provided for the soldiers and sailors, at some distance. These means could not fail of being very proper, and much more useful than water- ing the doors of the houses, than the smoke of the branches of green pine burnt in the public squares and streets, the fumigating and sprinkling the houses with aromatic vinegar, and the firing off of gun-powder in different quarters; means truly of small avail in purifying the atmosphere of a city such as Cadiz. Queries respecting the Yellow Fever which appeared at Cadiz in the year 1800. 1. Is it quite certain that this disease was the yellow fever? 2. Is it sufficiently proved that it was contagious? 3. Is it a certain fact that the corsairs and sailors brought this disease into Cadiz? 4. What are the circumstantial details which prove these assertions? 5, The heavy rains of the spring, the ex- K2 ( 102 ) eessive heats of the summer, the hot and constant easterly winds, the hardships which the inhabitants had experienced, and were still suffering—were these not sufficient cau- ses to give rise to a disease dreadfully epi- demic, contagious, and mortal? 6. What were the means employed for arresting its progress? 7. How were the means of curing and destroying it discovered? 8. If it was contagious, how came its progress to be stopt amongst that class of people who possessed neither the means nor the possibility of avoiding the contagion? 9. If it was evidently contagious, how came it not to be communicated at other times, when there were received into Cadiz without precaution, persons recently con- valescent, and perhaps attacked with the yeUow fever, coming from Carolina and Philadelphia? If a predisposition be requi- site to produce it, the disease then cannot be eminently contagious. 10. The influences of seasons, times and situations, are equally fatal to all, and not ( 103 ) more so to the poor than to the rich. The effects of contagion, on the contrary, may be prevented by persons possessing the • means of preserving themselves from it. As to the poor, it is impossible for them to avoid it, particularly, if they have any sick amongst them. 11. Was the number of deaths known ? 12. Was it as considerable as is re- ported I. Ssepe fama crescit eun.do. ( 104 ) ON THE DYSENTERY. 1 HE dysenteric flux attacked a great number of our soldiers in Egypt, at the be- ginning of autumn, in the year 6 (1798), that is to say, when the coolness of this season began to moderate the excessive heats< of summer. Obstructed perspiration was the chief eause of this disease. It is well known that when the pores of the skin are closed up, the fluids are carried to the intestines, and: give rise to diarrhcea. Cutis stricta, alvus- lax a est. Sanctorius has proved to us, that of the eight pounds of nourishment which a man takes during the twenty-four hours, he loses five by perspiration. If this perspiration happens to be stopped by any cause what- ever, derangements in the animal functions must necessarily follow. Experience has shown us that it is to the intestines the fluids are carried, and produce diarrhoea. ( 105 ) This disease showed itself on the majority of our soldiers a very short time after their arrival in Egypt. We have said, in the In- troduction, that the nights were cold and damp, and that the men took no precaution to guard against their bad effects. Hence,. amongst other inconveniences which neces- sarily followed, our troops were first at- tacked with diarrhoea. The pasteques, or water-melons, the milk,, and the water of the Nile, which our soldiers drank in too great a quantity, contributed to keep up this excessive evacuation. In several indi- viduals, the diarrhoea degenerated into the white dysentery; and it was not unusual to hear the patient say, " My stomach does not now digest my food, for it passes in the same state as when I take it." They did not suffer any cholic pains, and very few made use of any remedies for its cure. The frequency of the stools did not fail to irritate and heat the extremity of the rectum. This excoriation was nothing but the effect of the quantity, and not the quality of the stools, as the slight inflammation which attacks the ( 106 ) nostrils in coryza is owing to the quantity of lymph which flows over the parts, and not to its acrimonious quality, as some suppose. Besides the fluids of perspiration, which are carried to the intestines, the bile flows in a greater quantity into this canal, the stomach loses its strength, and the gastric juice becomes less powerful, or when scarce^ ly secreted, flows into the intestinal tube; on account of the over-increase of the pe- ristaltic motion. This derangement of the stomach must of course produce bad diges- tion; and the half-digested food must give rise to the disengagement of a quantity of air. It is to this particular gas that I attri- bute the first cholic pains which the sick experience. In this period of the disorder there supervenes, in my opinion, on the irritated parts, some slight inflammations upon different spots in-the intestines, and segments of the internal coat are in some points detached, whence there follows the mucous or glary dejections, which many persons call the grease of the intestines, { 107 ) When the diarrhoea has arrived at this second stage, it is then become dangerous, and requires to be treated in the manner we shall now point out. If we neglect to use the means proper for checking the progress of this disease, it very soon becomes a true bilious fever, accom- panied with very frequent stools, requiring very considerable efforts to void a quantity of glary and often bloody matter. Several of the sick in this state, weary of following the advice of physicians, tried to arrest the course of their disorder by eating hard boil- ed eggs, sprouting beans, and other reme- dies, considered as specific. A great weight at the stomach, burning thirst, bilious vomit- ings, stools of a blackish colour, putrid, and of an insufferable stench, were soon the consequence of this bad practice. But still, hoping to be cured in twenty-four hours, they preferred going on taking a load of medicines, directly contrary to each other, which were given them by quacks; and in this manner completely dissipated the little strength they had left. ( 108 1 After this statement, it is easy to be per- ceived that I distinguish three stages in the dysentery of Egypt. The first stage is the simple flux, or diarrhoea; the second is when it is accompanied by cholic pains, and mucous evacuations; and the third, when fever shows itself, and the evacuations be- come bilious, putrid, and bloody. Treatment, and means of preventing this Disorder. The indications which present themselves in the treatment of the dysentery, vary ac- cording to the different stages of the dis- ease. In general, in the simple flux it is necessary to facilitate the evacuation of the putrid or vitiated matter contained in the stomach and intestines; to diminish the great sensibility of these parts, and to re- establish the obstructed perspiration. In order to facilitate the evacuation of the pu- trid and vitiated matter in the stomach and intestines, I constantly prescribed an emetic in the morning. I preferred ipecacuanha to ( 109 ) the tartarised antimony; and in the even* ing I gave the sick an anodyne draught, with twenty drops of the liquid laudanum of Sydenham: I recommended to them at the same time to keep themselves well co- vered, and I afterwards made them take some boluses of diascordium, the white de- coction for ordinary drink, some rice and sheep's trotters for food. The oranges and pomegranates, fruits in great abundance in this country during the season when this dis- order prevails, were very useful in quench- ing the thirst and refreshing the mouth, without relaxing the stomach and intestines, as watery drinks are apt to do. Afterwards, the conserve of orange peel, preserved with sugar and not honey, coffee, and a little Cy- prus wine, contributed greatly to strengthen the functions of the stomach. When the evacuations had recovered their proper consistence, the patient was considered as cured : but if a too great con- stipation followed, glysters were preferable to purgatives, since the slightest laxatives exposed the patient to a relapse. When the I, { no ) fitix was accompanied with colic pains, and the patient's stools were mucous and glary, I had recourse to injections of de- coction of lintseed, poppy heads, of milk, of broth made from tripe and sheep's trot- ters, &c. &c. For a long time, and under different circumstances, I made use of a number of remedies, cried up in that country as specifics in the cure of the dy- senteric flux; but I have never been able to collect a sufficient number of facts to convince myself of their good effects. I am persuaded, that in order to treat this disease in the second and third stages, we must pay attention to the constitution and strength of the patients, in order not to irritate too much with tonics and as- tringents on the one hand, nor to relax them by laxatives and refrigerants on the other. I have seen individuals, to whom bleeding was of great utility: I have also seen others, to whom it proved quite the contrary. Opiates have, in the course of twenty-four hours, cured some who had $?een long ill, without any inconvenience ( 111 ) accruing afterwards; but I have seen the same class of remedies augment consider- ably the fever and colic pains in persons of a meagre, delicate, and bilious habit. In this case lemonade, with the acidulous tartrite of pot-ash, or the tisan made from tamarinds for drink, rice for food, and glys- ters of milk, produced the best effects. I am, however, persuaded, that the food of which the sick made choice,, and the ex- cesses which they committed, were fre- quently the chief causes which prevented their recovery. When the dysentery, accompanied with fever, has arrived at its third stage, the fever ought to- be treated as putrid, and the, bilious evacuations accompanying it should not be stopt; but as soon as we can flatter ourselves with having evacuated all the bile and other corrupted matter, by a moderate use of gentle laxatives, sometimes giving a weak decoction of rhubarb, at another small doses of ipecacuanha, we ought then to have recourse to anodynes and opiates. ( 112 ) Citizens Desgenettes and Larray, chief officers on the medical staff of the army of the East, and all my colleagues, have ac- knowledged, in the treatment of this dis- ease, the sovereign powers of opium, which, administered at a proper period, produces constantly the best effects. I have not had occasion to make use of blisters, as I do not believe them to be of much utility. In order to quiet the pains in the abdomen, I have always preferred, in every kind of colic, to have recourse to anodyne fomentations and tepid baths, when the strength of the patient admitted of it, according to the practice of Pringle, Lind, and other celebrated authors. These great practitioners, in order to dispel the pains, likewise made use of a blistering plaster applied over the abdomen; and Citizen Barbes, physician in ordinary to the army of Egypt, used to apply large blisters over the abdomen of several patients at- tacked with dysentery, of whose safety he despaired, and in a few days they recovered, (See the Egyptian Decade.) ( IIS ) Several persons stopt the dysenteric flux by giving small draughts of decoction of the peel of pomegranate, three times a day, or still oftener. InUpper Egypt they make use of quinces seasoned with pepper, to stop the diarrhoea-and dysentery. In Italy they boil this same fruit in a small quantity of water till it becomes reduced to a jelly, which they give with advantage by spoon- fuls to the. sick. In France it is given in the form of a conserve. Amongst the remedies which the physi- cians of Cairo recommend for curing the dysentery, is a fruit, from Sennaar, called hao-bab, or the monkey's bread. The rind of this fruit powdered and taken in small doses, frequently repeated, as well as the substance adhering to the seeds, which has a sourish-sweet agreeable taste, is extolled as a specific in the dysentery of Egypt. I mvself made use of it at Cairo in several cases with advantage; and I found in the sweet powder of the hao-bab, an antiseptic as well as an astringent, quality. The means to be employed for preserv- L2 ( 114 ) ing oneself from the dysenteric flux, con- sists in avoiding the suppression of perspi- ration, by sleeping in a well-closed apart- ment, and by covering oneself thoroughly when forced to pass the night in the open air. It is very useful in Egypt, in order to prevent too great a relaxation of the fibres of the stomach, to mix with the Nile wa- ter, which serves for ordinary drink, a little brandy, in preference to vinegar. This pre- caution becomes the more necessary, if much use be made of lemonade. The want of wine is of great consequence to those who are habituated to that liquor. In Egypt they who substituted brandy and coffee in place of wine, enjoyed good health : those, on the contrary, who drank nothing but the Nile water in great quantities, and took a good deal of milk, greens, and watery fruits; who, in the evening and night, to enjoy the cool air, undressed themselves, or slept upon the damp ground, were attacked with dy- sentery ; and when these individuals perse- vered in following this regimen, they were soon under the necessity of applying for ( us ) medical assistance. Doctors Bruant, Bar- bes, Savaresi, and Renati, physicians in or- dinary to the arfny of the East, paid par- ticular attention to this disease. (See their Memoirs in the Egyptian Decade.| ( 116 ) ON THE OPHTHALMY OF EGYPT. 1 HE ophthalmy of Egypt is a true de- fluxion of humours which deposits itself either upon one eye only, or upon both at the same time. This disease is endemial, sporadic, and epidemic; and takes place principally on the approach of autumn. Autumno lippitudines 8C oculorum fluxiones Jhint. (Hippocrates.) The ophthalmy of Egypt showed itself among the soldiers of the army of the East at the commencement of the year 6 (1798), and continued till the month of Frimaire (middle of November) in the year 7 (1799). More than two-thirds of the army were attacked almost at the same time, which made the duty of the garrisons very severe. This disease harassed not only our soldiers, but also the inhabitants of Lower and Up- ( "7 J per Egypt. The common duration of the ophthalmy was from seven to eight days. I have seen a great many recover in less time, and I have seen others continue to suffer under it for several months. Many individuals, after having, been cured of ophthalmy once, were attacked again. I had a little Maltese servant, who had this disease euery time that he slept in the open air. Those who took care to manage them- selves as they were ordered, recovered per- fectly in a short time; others had a great deal of difficulty in getting rid of this dis- order; and some who unfortunately were at a distance from all medical assistance, contracted very complicated organic affec- tions, which often terminated in the total loss of the organ of sight. Description of the Ball of the Eye. The wish which several very respectable persons have expressed of having first some ideas of the organization of the ball of the ( 118 ) eye, has induced me to give the following short description : The eye is composed of three coats, which are, the cornea, the choroid, and the retina; and of three humours, namely, the vitreous, crystalline, and aqueous. The cornea is divided into the transparent and opaque cornea. The opaque cornea is the most external coat, or what is commonly called the white of the eye; its texture is very compact, and like that of the cornea: it extends from the bottom of the eye forwards to the an- terior part, where it meets the transparent cornea: The transparent cornea is the most ele- vated part, commonly called the black of the eye, and may be compared to the glass of a watch set in its case. The transparent cornea is composed of a great many very minute diaphanous la- minae, placed the one over the other, and has a serosity which exudes through the pores of these laminae. The choroid is a coat like the skin of a ( H9 ) black grape; it is spread all over the opaque cornea, from the bottom of the eye to its junction with the transparent cornea. The retina is a coat formed by the ex- pansion of the optic nerve : it is very mi- nute, soft, of a whitish colour, and spread over the bottom of the eye. The optic nerve is a round white cord, which extends from the brain into the ca- vity of the eye, where it is expanded, and forms the retina. The cavity of the eye is divided into two chambers, the one called the anterior, and the other the posterior chamber: the first is very small; the second forms almost the whole cavity of the eye. The diaphragm, or membranous circle, which divides the cavity of the eye, is cal- led the iris. This very delicate and minute membrane is contiguous to the termination of the transparent cornea, at the place where it is united with the opaque cornea, and has in its middle a small hole called the pupil, which contracts itself in a strong light, and dilates itself in a weak light. The ( 120 ) colour of the iris varies, and according to its varieties, the eyes are black in some persons, and blue in others. The posterior chamber of the eye is filled by the vitreous and crystalline humours, and the anterior by the aqueous humour. The vitreous humour is so named from its resemblance to melted glass : it is formed by an extremely fine coat, which includes in its cells a kind of gummy water. The crystalline is a little transparent body, like a diamond, of a lenticular form, convex on its two sides: it is placed on the anterior part of the vitreous humour, imme- diately behind the pupil, where it is retained by a very minute coat, called the crystal- line. The anterior chamber comprehends the space which remains between the crystal- line lens and transparent cornea, where we find the aqueous humour, so called from its resemblance to water. The rays of light which convey to the eyes the images of bodies, undergo a refraction in passing through the transparent cornea ( 121 ) and aqueous humour: after having passed through the pupil, the crystalline lens causes them to undergo one still greater, which is lessened by the vitreous humour, and the image is stopt by the retina, the seat of sight. The ball of the eye is covered by two eyelids, the one the superior, the other the inferior; and we distinguish here two angles, the one the large, or internal, the other the small, or external. The eyelids, or palpe- bral, are formed by strong minute liga- ments, which support two small curved car- tilages, running lengthwise on their edges, which are called tarsi: these tarsi, towards the great angles, have two holes, called la- chrymal points; they are fringed with hairs, known under the name of cilia. The palpebral are covered by the common in- teguments, and are lined internally by a soft flaccid membrane, known by the name of conjunctiva, which is stretched over the surface of the eye as far as the transparent cornea. The inner surface of the palpebral is furnished with a number of follicles, M ( 122 ) called the glands of Meibomius, which se- crete from the blood a peculiar fluid for the purpose of keeping the eye moist, and les- sening the effects of friction, which results from the continual winking of the palpe- bral. A small gland, situated under the smaller angle of the orbit, furnishes the tears, and ,is called the lachrymal gland. At the great angle of each eye we ob- serve a little reddish tubercle, which se- cretes a mucilaginous fluid, that contributes -to retain in the great angle, the dust and other foreign matter which are casually blown into this part. I saw, in Egypt, -several individuals who had hairs in this tubercle. The fluids secreted by the lachrymal glands, the serosity which exudes through the pores of the transparent cornea, the fluids of the glands of Meibomius, and of the tubercles, after having moistened theball of the eye, are absorbed by the lachrymal points, and carried into the lachrymal sac, and from that by the nasal canal into the ( 123 ) nostrils. All these parts have, in their organization, arteries, veins, nerves, and lymphatic vessels, which it would be too tedious to detail. Description of the Ophthalmy. The ophthalmy of Egypt first showed it- self by a slight head-ach: sometimes it was preceded by a few shooting pains in the ball of the eye, followed by a flow of tears, which, for the moment, assuaged the pain : often the patient fancied that he had a par- ticle of sand in his eye, which distressed him. We generally remarked, that those in the best health were attacked all at once with ophthalmy, accompanied with an un- easiness and considerable weight in the eyes, followed by an excessive flow of scald- ing tears, to make use of the expression of the sick. On examining the eyes in this state, the vessels of the conjunctiva ap- peared red and distended; often the con- junctiva was elevated to such a degree, that Jhe transparent cornea appeared quite bu- f 124 ) ried in it, and of very small diameter. Then the palpebral became cedematose, the pa- tient could no longer endure the light, the flow of tears increased, and generally be- came changed into a thick, and sometimes yellow matter.* I think we may call the ophthalmy, ar- rived at this stage, although very severe, the simple ophthalmy; and the ophthalmy complicated^ when the gorging of the con- junctiva, the swelling of the palpebral, and the pain of the eyes became so consider- able, that fever showed itself, and some in- jury or organic lesion was perceived in the ball of the eye, as specks, staphylomas, hy- popius, and other diseases peculiar to this organ. * This matter was nothing more than the fluid of the glands, or follicles of Meibomius, which the inflammation had ren- dered thick. We see this change happen to the skin in slight burns, and after the action of cantharides ; for the first day there is nothing poured out from the affected parts but lymph, the day after, thicker matter, which finally becomes changed into true pus. The inflammation of the conjunctiva, in the ophthalmy of Egypt, and that of the membrane of the urethra* afford discharges, of which the appearance is exactly similar. ( 125 ) Causes. With regard to the cause of the ophthal- my of Egypt, some say that it is the sands of the desert which bring it on; others, that it is ammoniac mixed with the dust; and others that it is nitre. Savaresi says, that the nitrate of pot-ash, which has been im- properly called nitrous dust, does not at all injure the eyes, but that it is the clay which has alumine for its base, and the chalk, which is a combination of the carbonic acid with lime, earthy substances widely scat- tered over the whole soil of Egypt, which cause the ophthalmy. (See the Egyptian Decade, vol. ii. page 161.) Amongst the causes, I consider the in- tense light of the sun as the principal, and that what contributed most to cause a de- termination to the delicate parts of the ball of the eye, was a considerable degree of ir- ritation, followed by an indirect debility, to make use of the Brovvnonian expression. It is not in Egypt only that we find com- M2 ( 126 )■ plicated diseases of the eyes, but in many other places. At Bologna in Italy, for ex- ample, when a stranger arrives there, he is not long in remarking a considerable num- ber of blind people, who, during the day, sing and play on different instruments in the squares of this great city: one also observes. there a great many individuals, who have the eye-ball projecting, and more bulky than in its natural state, and staphylomas, specks, and other defects of that kind. It is well known that these affections are the conse- quence of different inflammations caused by the light of the sun reflected from the walls of the houses, which are white-washed with lime. This light, during the summer, be- comes so intense, that it fatigues and in- jures the organ of sight, particularly in those persons who, from their sphere in life, or property, cannot avoid it. (See the Memoires de la Institut de Sciences de Bologne.) At Malta, in the year 7 (1799), one half of the garrison was attacked with the me- ralopie. This disease was attributed to the too great irritation caused by the rays of the ( 127 ) sun reflected by the surface of the walls, and from the ground, which is composed of very white calcareous earth.* In Egypt the view of immense barren plains, the reverberation of the rays of the sun, reflected from the ground,, intersected with streets and squares, and from the water and sandy banks of the Nile, the heat and blaze of which are so great at mid-day, that the eye can scarcely see the spot where one^ wishes to place one's foot, must necessarily enfeeble, fatigue, and dispose the organ of, sight to particular affections. The masons of Egypt being more exposed to this glare of light than others, have almost all dis- eased eyes. Savaresi asserts that this arises from the lime which they are constantly handling, and from the atmosphere in which they live, being loaded with chalky, argil- laceous, and calcareous particles.^ The fol- * Citizen Rober, physician to the army of the East, at the head of the hospital staff of the island of Malta, has made some very interesting remarks upon this disorder, on the topo- graphy of the island, and the physical and medical constitu- tions of the years 6, 7, and 8 (1798, 1799, and 1800). It is to be wished, for the benefit of the profession, that he may commit this w. ( 141 ) when the strength and constitution per- mitted. When the ophthalmy approached its ter- mination, the patient began to distinguish objects, which appeared to him surrounded with a thick mist; this mist disappeared by little and little: the conjunctiva re- covered its natural colour instead of the purple hue which it had before;, the exces- sive sensibility of the retina diminished;; and, at length, after a good deal of time, trouble, and suffering, the patient found himself quite recovered. But when the oph- thalmy became complicated with organic lesion, the consequences were much more troublesome; the treatment varied accord- ing to the seat and nature of the affection;; sometimes the conjunctiva was so very turgid, that it projected quite beyond the palpebral, which then could not entirely cover it. In this case, besides the common remedies, we recommended and practised scarifications, and even horizontal incisions, thereby removing whole portions of the conjunctiva; but I observed that this prac- ( 142 ) lice was seldom productive of any good ef- fects: therefore I prefer the application of leeches, which bring away a greater quan- tity of blood. The use of the citron oint- ment, No. 14, was of some use, and gradu- ally removed the turgidity of the vessels of the conjunctiva. At other times the portion of the conjunc- tiva lining the palpebral,, became so volu- minous, that these were reverted, producing the most hideous effect: we then made use of the same remedies as in the turgidity of the conjunctiva. A bandage indeed was suggested, to compress and retain in its po- sition the superior eyelid, after having care- fully replaced it; but it very soon became reverted anew. The majority of those individuals who were attacked with this particular affection, had,, at the same time, some other defect in the ball of the eye: in some the whole of the transparent cornea was become ei- ther opaque, or projecting,, or ulcerated. In this last case, the transparent cornea being - no longer able to resist the pressure of the ( 143 ) humours contained within the eye, gave way, and the patient at this moment expe- rienced a shock which he compared to the shot of a pistol, the aqueous humour escaped as at the moment of the incision of the cor- nea in the operation for extracting the ca- taract, and the iris coming into contact with the cornea, adhesion of these parts took place, and cut off every hope of re- storing sight to these unfortunate sufferers. When specks arose from pus collected be- tween the laminae of the transparent cornea, they disappeared on giving the matter vent; and when produced by the inflammation of the cornea, they vanished and re-appeared, in proportion as the inflammation dimi- nished or increased. In several soldiers whom I accompanied from Egypt to France, I observed that the specks which they had at their departure from Alexandria, were diminished after some days sail; and on their arrival in France they clearly distinguished objects, not only sideways, as before, but when placed di- rectly before them. I know some of these ( 144 ) Individuals, who had been reported as in- valids in Egypt, and who are at this time in the Consular Guards. Whenever the specks on the transparent cornea do not arise from the disorganization of its laminae, there is always reason to hope that the lymphatic vessels will absorb the extrava- sated and thickened fluids forming these specks ; but whenever the organization is so much changed, that the transparent cor- nea is become opaque in its centre, then there remains no other method of restoring vision, but performing the operation for the artificial pupil.* The staphylomas, hypopions, cataracts, and other similar consecutive diseases re- quire particular treatment, and the most delicate operations, which it was not always * 1 had made at Reggio, in 1788, a small pair of forceps for separating a portioa-of. the iris from the opaque cornea, and making in this manner an artificial lateral pupil, in the form of a. crescent. In the year 5 (1797), Citizen Demours, a celebrated oculist in Paris, succeeded in making an artificial pupil, by cut- ting off a small shred quite close to the opaque cornea, where there did not remain above a fifth of the transparent cornea in a natural state, and separated from the iris. This operation has been followed with the greatest success, and proves the daily progress of surgery in France. I 145 j prudent to undertake in Egypt. Citizen Larray performed at Cairo some operations of this kind with various success. This in- genious and zealous practitioner was one of the foremost in applying himself to inquiries into the nature of the ophthalmy, and pre- sented to the Institute of Cairo a very full account of this disease. Citizens Bruant and Savaresi have also inserted some reflections on this subject in the Egyptian Decade. The Treatment used by the Egyptians for the Cure of tlie Ophthalmy. When the natives of Egypt are attacked with the ophthalmy, they cover their eyes with several muslin handkerchiefs, and are very careful not to touch or apply any thing •to them during the first seven days. At night they cover, with great care, their head and body, by which means the perspiration is restored, which greatly contributes to their recovery in a short time. Often severe symp- toms show themselves; and then they make use of various powders, and astringent and O ( 146 ) tonic collyriums. (See the table, p. 148.) Several have their heads shaved, and scarifi- cations made on their temples and fore?- heads; they apply leeches to the angles of their eyes, and cupping-glasses to the nape of the neck,* blisters behind the ears, where they also sometimes apply cautery; they, at the same time, make use of different oint- ments, and coloured and thick collyriums; for if the Collyriums were liquid and trans- parent, they would, in their opinion, be hurtful and injurious to the eyes. At Giseh, and other places, I have seen them paint their eyebrows and all the edge of the orbit, with a pencil dipt in a mix- ture, either white or yellow, or sometimes black. It was difficult to keep oneself from laughing at seeing these poor sick people almost blind, with the contour of their eyes besmeared with these different colours. * The Egyptians, for performing this operation, make use of a small cow's horn, open at it? base, the other extremity also open, and provided with a kind of parchment valve: they place the base of this horn upon the skin, at the spot where they wish to perform their cupping; they then exhaust the air by means of suction, and after having in this way formed the necessary vacuum, they close the valve, which prevents the en- trance of the external air into the cavity of the horn. ( 147 ) They were expressly forbid to touch, wash, or cover their eyes, and were not to use anf other remedy for three days, if they wished to get well. The astonishing number of persons of both sexes, blind in one or both eyes, whom one meets with in Egypt, proves that theiu treatment is not at all efficacious. Indeed, in the complicated ophthalmies/ what can we expect from such remedies, but loss of eyesight, as some of our soldiers experi- enced wTho were thus treated. I agree with the inhabitants of Egypt, that emollients, cataplasms, and water, are hurtful in the cure of this disorder; but I assert likewise, that to neglect every kind of remedy is to confide too much to nature, and too little to the resources of art. Their principle of fatalism, God decrees, God has decreed, makes them neglect many things which might be of utility to their health.* * Amongst the great number of blind people whom I ex- amined at Cairo, I saw very few individuals who had true ca- taracts capable of being operated upon with success. The ma- jority had either staphylomas, or the cornea totally opaque, or the eyes almost entirely evacuated. When I proposed to cure those having cataracts by means of a small incision, they r£- ( 148 ) Powders, Ointments, and Collyriums, used in Egypt in the Treatment of the Oph- thalmy. No. 1. Nut galls and pulverized anti- mony, each equal parts; mix and make into a powder. No. 2. This powder, mixed with vine- gar, forming a kind of ink. plied to me with the greatest coolness, J shall be cured without any incision if God decrees it: and it was not possible for me to persuade any of these fatalists to allow the operation to be per- formed. Citizen Berti, of Venice, surgeon oculist, only performed at Cairo, during eighteen months, two operations for the ca- taract, on two beys, with whom lie was very much displeased, because, after having completely cured them, they said that they could not see so well as formerly, and that the operation had been badly performed, because he had not evacuated the humours of their eyes with his lancet. This instance of the folly of the Turks made me determine to abandon the operation for the cataract, to which I had paid a good deal of attention when in France and Italy, where I had practised it with success, both according to the method of Demours, and with an instrument of my own invention, which bears some resemblance to that of Guerin. I had this instrument made at Paris in 1786: it was presented to the Academy of Sciences by Citizen Sebatier, who wished much to read to them my sentiments upon that instru- ment, and likewise upon that of Citizen Guerin, of Bcurdeaux, which had then appeared at Paris. Citizen Malacarne, professor of surgery at Padua, had these same reflections, and the case in which I had made use of my1 instrument with success, inserted some time afterwards in the Journal of Citizen Bragnatelli, entitled, Bibliotbeca Physko jtfedica. ( 149 ) No. 3. Sugar-candy, sulphate of alumine, nitrate of pot-ash, equal parts; mix and make into a powder, for destroying specks on the cornea. No. 4. Chichm* in powder, sugar-candy, alum or sulphate of alumine, equal parts; mix the whole with vinegar. No. 5. Infusion of saffron, and some drops of the tincture of opium as a resolutive anodyne collyrium. No. 6. The soap collyrium, a solution of soap in alcohol. No. 7. The tonic collyrium, a solution of the sulphate of zinc in water, mixed with * The-chichm is a black seed very common at Cairo: it is brought by the caravans from Darfour and Senaar. Citizen Delille, member of the Institute of Cairo, sowed this seed in Egypt: it gave the cassia, absus; Linnaeus, ccssia hispida ; of which he communicated to the Institute of Egypt, and that of France, the following description:—The cassia, absus, is a small hairy plant, whose stalk is slender and herbaceous, its leaves alternate, pinnate, composed of two pairs of leaflets, occupying only the upper part of the plant. The flowers are of a-deep yellow, and disposed in little loose clusters; they pro- duced hairy, narrow, compressed pods, about five centimetres in length (one inch), enclosing black roundish-oval shining seeds. Citizen Fontaine, professor at the Jardin des Plantes, told me, that about three years ago Citizen Olivier, member of the Institute, had brought this seed from Persia, under the name of' cassia, absus; that these seeds had been sown in the Jardin des Plantes; and that they also had produced the cassia hispida. 02 ( 150 ) vinegar and brandy; useful in affections of the palpebrae and tarsi. No. 8. Muriate of soda, dissolved in water, mixed with vinegar; useful in the simple ophthalmy. No. 9. Solution of verdigrise. No. 10. Solution of acetite of lead. No. 11. Cerusse mixed with water, used to paint the contour of the eyes white. No. 12. Saffron bruised and mixed with cerusse, and a little vinegar, for painting in yellow. No. 13. Ink of antimony, for painting in black. (See No. 1.) No. 14. The desiccative ointment, made by adding some oxyde of mercury, formed by the nitric acid to any ointment. No. 15. The vegeto-mineral water. On the Means of preventing the Ophthalmy. We have already said that it was not at all difficult to preserve oneself from the ophthalmy, provided we keep ourselves pro- tected from the currents of cold and damp ( 151 ) air, it being well known that this precaution alone is sufficient. At Cairo, the Monks and Franks, and also those inhabitants who adopt proper precautions, are not at all sub- ject to this disease. The soldiers on guard, or upon night piquet, should, during the night, cover up well both their head and feet, and particu- larly if they are obliged to make a voyage on the Nile; and in cold and damp places, they should avoid, as much as possible, the smallest currents of air. Several persons have been attacked with the ophthalmy after having slept near a window which had not been properly closed, it was in this way that Citizen Fevre, engineer of bridges and causeways, and member of the commission of arts, was attacked with the ophthalmy in one eye, the first night after his arrival at Cairo from Syria, although he had slept the preceding nights in the open air, in a bark on the Nile, without experiencing the smallest inconvenience, because he had taken care to keep himself well covered. He had a great deal of difficulty in getting rid ( 152 ) of his ophthalmy; and if he neglected for a single day to make use of the collyrium (No. 9), he was attacked without fail on the day following. We have remarked, that this collyrium prevented or stopt the progress of the ophthalmy; and I have no doubt that it might also be useful as a pre- servative.. This slight styptic must neces- sarily act uponthe vessels of the conjunctiva, the lachrymal ducts, the glands of Meibo- mius, the lachrymal caruncle, the pores of the cornea, and- preserve these parts from that state of relaxation which is the princi- pal cause of the ophthalmy of Egypt, andr of a great many of those of Europe. The- general of division, Beillard, was severely attacked with the- ophthalmy at Giseh, while he commanded that province. He attributed his cure to that same collyri- um ; and sometime afterwards, having gone into Upper Egypt, I sent to him, as a pre- servative, a mixture of verdigrise and ace- tite of lead in powder, which he dissolved in rose-water. When he happened to be short of the collyrium, I recommended to ( 153 ) him the use of a mixture of brandy and pure water. The ointments, besides other in- conveniences, were very apt to turn rancid. In order to diminish the impression of the light, green spectacles have been recom- mended. This method is very good, but one must use spectacles a little better made than those which the Turks sold to us. They consisted of a half-mask of Morocco leather, furnished with two miserable pieces of coloured glass, pasted between two bits of leather: they lay too close upon the eyes; and heated them very much. Indeed, all those who used them, laid them aside in a short time, after having experienced not only their inutility, but also their inconvenience. As to myself, I never made use either of spectacles, of collyriums, nor of any pre- servative to protect me from the burning sand, the nitric, ammoniacal, or calcarious dust, nor even to protect myself from the excessive light: but at no time either the refreshing coolness of the evenings, or the beauty of the nights, could induce me to kave my windows open, or to sleep in the ( 154 I open air; and when I was obliged on duty to do so, my boat-cloak served me for a tent, and became my aegis. Note. I have no doubt that the catarrhal ophthalmy which prevailed at Vienna, in Germany, in 1799, was of the nature of the Egyptian ophthalmy. (See the Bibliotheq. Germanig. torn. iv. page 132.) j( 155 ) THE DESCRIPTION AND PLAN OF AN HOSPITAL FOR SOLDIERS, Attacked in Egypt with the Disease called the Plague. J.N speaking of the disease epidemic in Egypt and Syria, called the Plague, we pointed out the means to be used for self- preservation ; but it must be confessed that it is not always in our power to avoid the causes which produce it; and the soldiers composing the garrisons of Alexandria, Rosetta, and Damietta, may be attacked with it, particularly during the rainy and unhealthy seasons. It is well known, that in order to cure any epidemic disease what- soever, there is nothing more useful than to place the sick in healthy, dry, and well aired places. ( 156 ) During the twenty years that I have stu- died and practised physic, I have seen a great many hospitals in Italy, Switzerland, France, England, and Egypt, and met with many very beautiful; but very few indeed which united the advantages necessary for the object proposed: that of Heggio is, in my opinion, the most healthy, and best con- ducted of all those which I have examined in detail. As surgeon in chief of this hos- pital for nine years together, I had every op- portunity of convincing myself of this truth. The large hospitals are seldom kept clean, and are always unhealthy on account of the number of sick brought together into the same place. The hospitals which I have seen in Lower Egypt, and particularly that at Alexandria, called the Hospital for Plague Patients, was more adapted for producing than for curing the fever. I am also well convinced, that it is by no means easy to convert churches and mosques into good hospitals,notwithstanding the good will and talents of the engineers; and if we consider the enormous expense which the repairs of ( 157 ) such a place require, before it is converted into an hospital, I am certain that one might have constructed the whole quite new. It is for the purpose of procuring, if pos- sible, for these establishments all the ad- vantages of which they are susceptible, that I have conceived the plan of an hospital for the garrisons of the principal cities on the coast of Egypt. I take for granted, that we follow the advice which I gave for pre- venting the epidemic fevers of this country at the same time; and then an hospital ca- pable of holding about one hundred fever patients will be sufficient for any garrison whatever, either at Alexandria, Rosetta, or Damietta; and if experience should prove that such an hospital as the one proposed will not be sufficient for the number of sick, we may construct, at a certain distance, another like the first; but we ought to avoid bringing together into the same place too great a number of fever patients. The crowding together a number of sick in the same hospital, has been, and always will P ( 158 ) be, contrary to the true principles of the practice of physic, whatsoever may be the disease; a fortiori, in the treating an epi- demic, whose symptoms are such as to have procured it the title of the plague. The hospital of which I submit the plan, will not contain more than one hundred beds : it will consist of three wards; a large one for the sick soldiers, a smaller for officers, and a third for convalescents. It will also have a sudatory, or dry bagnio, for oily fric- tions, the whole on the first floor. The ground floor will contain the necessary offices. This building will be very simple, and easily erected, particularly in Egypt. Particulars. There ought to be in each room for the reception of patients, a fire-place, a large bason, a cistern with a bath, some stone Seats and presses. There should be in the room for warm oily frictions, a stove chimney, or a fire-place d la Desarnold, and some presses. ( 159 ) In the great ward there should be two tiers of windows, one over the other; the latter should be open down to the floor of the wards, the better to renew the air, the carbonic acid of which always occupies the lower parts of the wards. They should have gratings formed of perpendicular bars for at least half their height, in order to prevent all accidents which might happen to pati- ents in a state of delirium. Each of these windows, or balconies, should be closed by two shutters, which should open into the wards ; their upper halves should be glazed, and have ventila- tors to facilitate the passage of light and air into the wards. The shutters of the windows should be made to fit well to each other, so that they may close accurately. The pavement of the wards should have some degree of slope inwards, so as to pre- vent, in case of any accident, or after wash- ing the floor, any moisture remaining under the beds, which is a circumstance very es- sential to the healthiness of an hospital, and generally too much neglected. ( 160 ) The necessaries in that part of the galle- ries which we have pointed out, would unite the advantages of being without the wards, and, at the same time, within the reach of the convalescents and those patients able to walk. They should be placed in excava- tions in the pillars, in the form of nitches, and should be paved and lined with marble. The water from the roofs should flow off by leaden pipes into the necessaries, as well as that from the cisterns; and the troughs for the tisans, that from the pharmacy, the kitchen, the baths, and wash-house, should be carried off into the sea, or the Nile, by the same common sewer. Such sick as are unable to go as far as the necessaries, should be placed, by the assist- ance of the attendants, on a copper vessel, tinned over on both sides, and the edges rounded off, to prevent its hurting the thighs of the sick : it should also be pretty strong and wide at its base, so as to sustain the whole weight of a body without any dan- ger of upsetting: it should likewise have a cover to fit its opening exactly. Hence, ( 161 ) when thus closed, it will not spread any dis- agreeable smell, which is an inestimable ad- vantage, particularly to the attendants. The earthen utensils commonly used should be banished from this hospital, since, if they are not quite new, they become infectious. If, during some of the days in winter, the cold be considerable, which is not uncom- mon, particularly at Damietta, it will be useful to light pans of coals in the wards, which will also help to change the air. Among other advantages attending this hospital would be that of having its own wash-house and burying-ground distinct, and, at the same time, quite near. Wehav-e all observed with what facility an alarm spreads itself in any city which is suspected of having the plague, while the sight of the dead bodies justifies the dread, and spreads dismay. I confess that I never saw any thing so hideous and shocking as the.ferry- boat into which the dead bodies proceeding from the hospitals at Jaffa were thrown, for the purpose of being taken out of the city to be buried. In the hospital which I P2 ( 162 ) propose, whenever a death happens, the body would be immediately removed into the dead-room, and afterwards consigned, along with some quick-lime and sand, to a deep grave in the burying-ground. The rose de vents (wind dial), in the in- terior of the tower, would point out to the officer on guard, whether or not it would be preferable to have the windows of the south or north sides opened, and whether or not the sick should be advised to remain in their wards, or to walk on the great terrace. By the aid of the necessary instruments with which modern philosophy has made us acquainted, it would be easy to learn not only the degree of heat, but all the other qualities or properties of the atmosphere. These meteorological observations, the me- dical topography of the environs of the hos- pital, as well as remarks respecting the suc- cession of diseases, and their causes, should be preserved in a journal kept for this pur- pose, which would become valuable towards improving the practice of physic. { 163 ) Citizen Desgenettes, in Thermidor of the year 6 (July 1798), addressed a very inter- esting circular letter to the physicians of the army of the East, recommending a plan for collecting the physical and medical topo- graphy of Egpyt. The majority of his fellow practitioners complied with the wishes of the physician general; but among their reports, I do not find the topographical, meteorological, and medical observations brought together into one journal, or table, as in thatwhich I-propose, and which would be very easily kept, whenever the medical officers were furnished with the necessary instruments. Subjoined is the form of a table, which would pretty nearly fulfil and present atone view the object proposed. ( 164 ) ' METEOROLOGICAL Made in the Military Commencing —— day At sun-rise. Two hours after mid-day. At sun-set. State of the sky. Direc-tion of the winds. Thermometer placed. In the ward. In the open air- C Sun-rise Monday. -\ 2 o'clock. £ Sun-set. C Sun-rise. Tuesday. <2 o'clock. (_ Sun-set. C Sun-rise. Wednesday < 2 o'clock. (_ Sun-set. C Sun-rise. Thursday. < 2 o'clock. £ Sun-set. C Sun-rise. Friday. -s 2 o'clock. £ Sun-set. C Sun-rise. Saturday. < 2 o'clock. £ Sun-set. C Sun-rise. Sunday. ■s 2 o'clock. C Sun-set. ( 165 ) OBSERVATIONS Hospital at of the Month ——, of — year. Barome-ter. Hygro-meter. Electro-meter. Nilome-ter. Observations. { 166 ) MILITARY HOSPITAL AT MEDICAL TOPOGRAPHY. PROGRESS OF THE SICK. THE SPECIES OF DISEASES. OBSERVATIONS AND REMARKS. ( 167 ) Practice to be followed on the Beception of the Sick into the Hospital. Whenever a patient arrives at the hos- pital, the porter should show him into the Small room adjoining the admitting board. There he must be examined by the surgeon on guard, who, after having made himself acquainted with the nature of his disease, should give him a billet, with which he should immediately pass to the room for receiving patients, where the store-keeper must make him undo his knapsack, and, after taking an accurate account of all his property, ought to throw his foul linen into a bason full of water, burn his useless effects, and then place the rest in the magazine for the knapsacks, and his mus- ket and sabre in the room for depositing arms: every article should have a ticket ' affixed. The patient, after being stript, should be washed with tepid water, and rubbed well with soap from head to foot, after the manner of the Turks. After this ( 138 ) operation, they should throw over him a shirt, a great coat and cap, and give him a pair of wooden sandals: he should then be conducted to the room for frictions. On being brought into this sudatory, he ought to be placed on a bed, and one or two hos- pital-attendants should begin rubbing him rather briskly from head to foot with a spunge dipt in warm olive oii. These fric- tions must be performed quickly, and .should not last longer than three or four minutes at farthest: the freshest and purest oil should be made use of. If he has buboes, it will be sufficient merely to anoint them. The patient should be well covered, and will then soon begin to sweat j to encourage which he should take some tea, or other diaphoretic drink. When the sweating be- gins to subside, the patient should be again dressed in his shirt and great coat, and re- moved, well covered, to a bed in the large ward, or into the officers' ward. These fric- tions should be repeated every day till the patient is out of danger; and when the physician thinks fit, he should be removed ( 169 ) into the convalescents' ward. It is useless to add, that the necessary medicines should be administered at the same time, to facili- tate the patient's recovery. As to regimen, that should be regulated by the attending physician. To those at- tacked with the plague at Smyrna, they give, during the first five or six days, some vermicelli, well boiled in water without salt; afterwards a little rice, some spoonfuls of sweetmeats, a cup of strong Moka coffee, and one or two biscuits. When the patient begins to get better, they give him some soup made with herbs, a little fine white bread, a few raisins, and a very ripe orange or pear. It is not till after the thirtieth day that they give him soup made from meat; and about the end of forty days they permit him to take a little boiled or roasted veal, with a moderate quantity of wTine. With respect to the duty and employ- ment of those attached to this hospital, the regulations should be nearly the same as those of the other military hospitals of the ^Republic. a ( 170 ) As it is of importance, in order to pre- serve oneself from this disease, not to re- main too long in the same place, the medi- cal officers, and all the attendants, should be relieved every two months, or sooner, if their health requires it. All the persons attached to the hospital ought to be lodged out of doors. The sur- geon and the apothecary on guard should be changed every twenty-four hours, and they ought to be at least three days off duty. The hospital orderlies, the servants, and others attached to the ward for receiving pa'ients, to the room for frictions, to the wash-house, stores, &c. should do duty al- ternately; and when they are not employed, they should be prohibited from entering the hospital. This measure is of more import- ance than may be imagined, since often the allurement of a few indirect gains, causes them to forget the dangers which they run by remaining too long close to the sick. I have seen these fellows lavish their attentions on some poor wretch, because he happened to jpossess a little money, and they foresaw that his death was at hand ; but no soonee had his purse or his girdle disappeared, than- their assiduities diminished, and the more rapidly if some fresh object for plundering happened to be presented to these demons of avarice. It was in this way that several indivi- duals contracted the disease, and finished their days without enjoying either the spoils or compensation* which they had scraped together. The salaries of the orderly men, as well as their rations of wine, brandy, and coffee, ought to be augmented, which would con- tribute to preserve them from the epidemic, and would induce them to pay attention to their duty. Before concluding, it will be of some utility to mention here some facts which have been published by Father Louis, of Padua, director of the hospital for plague- patients at Smyrna. In 1793 twenty-two Venetian sailors inhabited, during twenty- five days, a damp chamber on the ground floor, along with three persons affected with ( 172 ) the plague, who died: the inunction with oil saved all the others. In the same year three families of Armenians, one thirteen, the second eleven, the third nine in num- ber, preserved themselves by the same means, and attended on their relations who had the plague, without contracting the contagion, although they slept on the same beds, and supported almost constantly these poor creatures in their arms. In 1794 one poor woman remained shut up in the same apartment, along with thirteen persons hav- ing the plague: she nursed them all, and pre- served herself from the contagion, by using frictions with oil. One Ragusan family had that year two of its number attacked with the plague: they dipt themselves (if I may be allowed the expression) in oil, and, in consequence, entirely escaped. At this day the use of oily frictions is very generally adopted in the Levant. Citizen Peron, of Toulon, surgeon of the first class in the navy, who has resided at Smyrna for several years as a physician, communicated to me several particulars ( 173 ) respecting the plague and oily frictions, all which have confirmed me in the opinions which I have delivered in the course of this work. It is to be wished, that Father Louis, of Padua, and all those who adopt this practice, would publish their observa- tions; since, in my opinion, the frictions with oil are not only useful in curing, but in preventing the plague. I therefore felt anxious to propose the adoption, and to detail the particulars to be observed in the use of this remedy; and I will add also, that I think the use of oily frictions in a su- datory (frictions oVhuile (I etuve), may be made of much more extensive application. A great deal might be said on the modus agendi of this remedy; but I disclaim all system, and we have not as yet a sufficient number of observations on which to ground a theory: let us be contented, for the pre- sent, with consulting experience, and foL lowing its indications. If it should so happen, that, from the draining of the marshes, the plague, and other diseases of that nature, should dis- Q2 ( 174 ) appear, and the coast of Egypt, along the Mediterranean, should become as healthy as the rest of that fine country, this hospi- tal may then be appropriated to the recep^ tion and cure of patients having the itch and venereal disease, as the chamber of reception would serve for a bath, and in that set apart for warm oily frictions might- be performed the frictions proper in these diseases. After what I have set forth in this work* there could be nothing to be dreaded on the score of the contagion, which might be communicated to these fresh tenants; be-r sides an exposure to the air (une serene) of all effects for forty days, if judged requisite, would remove every danger and objection. Patients with dysentery, ophthalmy, and even those with wounds, might be also cured there> as they would be in no danger of hospital fever,, or gangrene: the surgeons might perform their operations in the room set aside for frictions. A fter an engage- ment, either by sea or land, or in case of a debarkation of troops, if more space should ( 175 ) be requisite, the great terrace which is above might be very soon converted into a ward, which would double the number of beds, and by placing those in the other wards a little closer, room might be made for three hundred provisional beds: and the same number of offices would be sufficient. for this service. During the time of an epidemic, the bringing together so great a number of sick would be perfectly inadmissible, and the hospital should then be put into its former state.. C !76 > REPORT MADE TO THE SOCIE TY or THE SCHOOL OF MEDICINE AT PARIS, Opon a Work written by M. Assalini, entitled, Observations upon the Disease called the Plague, &c. Extracted from the Registers of the Society of the School of Medicine of Paris: the Sitting of the 14th Ventose, Year 9 (6th March, 1801). 1 HE work which M. Assalini presents to the Society, under the title of Observa- tionson the Disease called'the Plague, &c. contains some remarks made by the author on the diseases which prevailed epidemically in the army of the East, both in Egypt and in Syria; upon some other diseases reputed contagious; the dysentery and the ophthalmy of Egypt; and the plan of an hospital proper for the treatment of the diseases which are epidemic in this colony. ( 177 ) The intention of the author is to make known the facts to which he was witness. He has drawn a conclusion differing widely in many respects from the common opinion, particularly on the fact of contagion, as well as on the supposed cause of the disease known under the name of the plague. We shall just give a summary idea of the observations contained in this work. In the Introduction, M. Assalini men- tions the circumstances which might pos- sibly affect the health of the soldiers, after the epoch of their landing at Alexandria, The heat of the days, the cold damps of the nights, the exhalations of the marshy lakes, the quality of the food, the scarcity and want of water during their march across the desert plains, from Alexandria to Cairo, in the year 6, the imprudence of sleeping out of quarters, or in the currents of air from open windows, comprise the whole of the causes to which the author attributes the greater part of the ophthalmies and dysenteries. He gives afterwards a short description of Jaffa (the ancient Joppa), ( 178 ) of the lakes which surround it, and the miseries which the war brought together in that city, in the course of the year 7 (1799). In the meteorological table of the year 7 (1799), at Cairo, we perceive the climate of Egypt characterized by a remarkable se- renity of sky, interrupted only in the month of Nivose (December, January) by some rains; and the whole year divided into six uninterrupted months of a clear serene sky, and into six other months of a sky covered with some clouds, among which are two months of mists; namely, the months of Brumaire and Frimaire (October, Novem- ber, December). After these preliminary remarks, the au- thor treats of the diseases which afflicted the army of Egypt during the years 6 and 7 (1798 and 1799), The principal is a disease which attacks several individuals at the same time; the chief symptoms of which are, fever, buboes, carbuncles, loss of strength, head-ach, and delirium ; which most frequently carries off the patient about the third or fifth, day, and ( 179 ) which every year showsr itself more or less, along the coasts of the Mediterranean and the Archipelago, from Alexandria to Con- stantinople. It has been called the Plagues a dreadful name, because it conveys to the mind the combined ideas of an inevit- able contagion, and almost certain death. Hence, to avoid the fatal influence of a word to which so dreadful an appendage has been linked, the author calk the fevers which desolated the French army by the name of epidemic fevers. By others it has been called the fever with buboes. Among the characteristic symptoms of these fevers, the author especially remarked an uncommon apathy, in consequence of which the patient seeks out some solitary spot, where, covering his head, and giving himself up to sleep, he becomes totally in- different to the most powerful calls of in-, terest; in which state he remains till seized with delirium: he dies on the third or fifth day after the.attack. Here M. Assalini puts the query, whe- ther or not this disease be really contagious? ( 180 ) The following are the facts on which he grounds his reply. Although a great many persons were at- tacked with the fever with buboes, after having had communication with the sick, there was a still greater number on whom this intercourse produced no such effect; and, on the other hand, many, in spite of the most complete shutting up, fell under its influence. The Egyptians, Syrians, and Turks, who communicated without any precaution with the sick, and shared the effects of those who died, did not contract the disease. The neglect with which the regulations of lazarettoes and the laws of quarantines, on the roads from Alexandria and Damietta to Cairo, were observed, did not occasion the disease to spread itself to the latter city. Into the hospital of Ibrahim Bey three patients were received, who died two days after of the disease; yet, of sixty persons who were then in that hospital, not one caught the contagion. The physicians of the country, and Citi- ( 181 ) zens Desgenettes and Larray, braved the contagion throughout: the first inoculated himself in the arms and groins, yet none of them were attacked with the disease. The author received on his hands the pus of buboes which he was laying open: he slept in sheets washed by a woman who died the next day of the disease ; a sick wo- man reposed herself on his bed, and died in like manner on the day after: yet he had no attack of the malady. In his inquiry into the causes which gave rise to the developing of this disease in the army of Syria, M. Assalini makes the foli lowing reflections. The Turks made prisoners at El-Arish,) and at Jaffa, could not have communicated the contagion, because they themselves were not affected with the disease. The division Kleber, at its departure from Damietta, was in very good health, in which - state it continued while crossing the desert: the army then arrived free from contagion j it could not, according to the author, meet with the germs of the disease, but in the fa- ll ( 182 ) tigue, want of water, and scarcity of live stock in the desert, in the winds, the rains, and the inconstant weather, and difference of the climate of Syria from that of Egypt, in the topographical disposition of the en- campments around Jaffa, in the marshy waters of a lake in the neighbourhood of which was encamped that division of the army which was the first attacked, although it came direct from Cairo. Rosetta^ Damietta, and Alexandria, sur- rounded by marshes, and of course exposed to the like influences, are subject to the same diseases. In Egypt the places elevated above the damp and infected vapours which fall down upon the plains, were constantly exempt from contagion. These vapours envelope the habitations of the lower country in a mist, which is very visible either at the rising or setting of the sun. Of the places which, on account of situation, are pro- tected from this scourge, the ciradel of Cairo is quoted as one instance. Its inha- bitants, during the plague of 1791, were ( 183 ) exempt from the disease, which laid waste the lower town, with which, nevertheless, they continued to hold constant intercourse. The author mentions other examples, pre- senting similar results. It is a known fact, that in the unhealthy latitudes of Africa and America, one method not only of preserving from, but likewise of curing those affected with the diseases ende- mic in those places, even when threatened with approaching death, is the removing them to another situation. Often the wished- for effect is produced by the mere change of place, although perhaps the spot to which the journey is made does not afford superior advantages in point of healthiness.* M. Assalini observed the same fact in the Egyptian fevers with buboes. He cites a great many instances, from which he con- cludes, that no distinction ought to be drawn between the causes and phenomena of the production of fevers with buboes, * In America, however, it is in the removing from the coast to the interior of the country, that these fortunate changes are* most remarked. ( 184 ) and of those which desolate other countries, and which have never been suspected to be of a contagious type. Lastly, the author mentions an observation which he thinks important. During all the time that the English pre- vented the arrival of any vessel in Egypt, the disease raged in the army of the East, On the contrary, when the blockade was abandoned, and Tripolitan, Algerine, and other vessels were permitted to come in, the disease did not take place during that period. From all these observations, as might be expected, M. Assalini concludes, that the disease which attacked the army of the East in Egypt and Syria, and which, considered in its individual symptoms, bore a good deal the character of the disease known by the name of the plague, considered collec- tively, was evidently epidemic, and not truly contagious; and that it was occasioned by local causes, and not by a germ brought from abroad. After these reflections, M. Assalini pro- ceeds to the consideration of the treat- ( 185 ) ment. He reduces it to three indications: to diminish plethora when it exists, to empty the primae viae when they are loaded, and to excite perspiration and sweating. As the two first indications are only condi- tional, it is evident that the third is that which he considers as essential and funda- mental. We shall not follow him through the de- tails, but will only remark, that one of the means of which he speaks most favourably, either as a preservative, or as useful in the treatment, is the use of corlee without sugar, mixed with citron juice, and given by cup- fuls five or six times a day. He treats pretty fully on oily frictions, which have been for some time celebrated, and appears to place a good deal of confidence in them. In general, the tonic and sudorific treatment followed by Citizens Desgenettes and Lar- ray in Syria, Dieche near Acre, Savaresi at Damietta, Sotira at Rosetta, Ghisleni and Balbes at Alexandria, constantly saved, he says, two thirds of the sick, the greater part affected with buboes. R2 ( 186 ) As to the particular treatment of the car- buncles and buboes, M. Assalini condemns the practice of opening or burning them with the actual cautery, before they come to maturity. He recommends the use of cinchona internally, externally anointing the tumours with oil; and he thinks that they should be opened whenever symptoms of suppuration have appeared. The particular precautions which M. Assalini made use of for his own preserva- tion, consisted merely in avoiding as much as possible remaining in the unhealthy places, making use of the best food he could pro- cure, and keeping himself constantly em- ployed, in order to avoid low spirits. He took care to arrive at the hospital without being in a sweat; before going his round, he drank a large cupful of bitter coffee; on leaving the hospital, he rode out on horse- back, till he brought on sweating; and, before going to bed, he took a cupful of punch quite hot, which made him perspire profusely during the night. As to the rest, he took no precautions against the contact ( 187 ) of the infected, except avoiding the direct impression of their breath. With regard to general precautions, one of the principal which he recommends, to support which he quotes a number of facts, and on which he relies with most confi- dence, is. the moving the troops, and suc- cessively changing the garrisons from one quarter to another. Lastly, measures of police for keeping the streets clean, and in good order, the necessity of paving them, and of draining the morasses by canals, and filling them up to prevent the stagnation of the waters, are precautions, the importance of which appears to him evident, on consi- dering the present state of the environs of Damietta, Rosetta, Alexandria, and the fort of Birket-El-Hadji, and which, con- jointly with the restoring and bringing to perfection the art of agriculture, appear to him necessary, in order to place Egypt in that state of salubrity which it undoubtedly enjoyed in the time of its ancient prosperity. May his wishes be accomplished: may the beginning of this century witness the ( 188 ) complete extermination of two of the most dreadful scourges of humanity, the small- pox and the plague ! After these different observations, the author gives an account of the customs followed by the Franks or the Europeans in the Levant, the precautions used in la- zarettoes, and the laws of quarantines. The particulars of this department of the public police are sufficiently known. But possibly some concern may be felt on seeing in what an unfavourable light the author views these establishments, from his comparing together the deplorable effects resulting from terror and shuttings up during the European plagues, and the less fatal effects, as he says, of the unconcern of the Mus- sulmen ; an indifference which at least prevents them from being deaf to the calls of their friends and relations, who, on their death-bed, implore their assistance. How- ever true the author's reflections mav be, his intention can never be to authorize the national gratitude to be withheld from the patriotism of those citizens who have esta* ( 189 ) blished and supported, to the present time, the lazaretto of Marseilles, and who, dur- ing twenty-four years, have been the senti- nels of France, for the purpose of preserv- ing the public health. M. Assalini next says a few words on the disease which, in the year 8 (1799- 1800), attacked the army of Italy in the Ligurian Republic. It was of the nature of the jail fever, and was not at all conta- gious. He adds some reflections on the yellow fever of Cadiz. The several ques- tions which he puts on this point, the doubts which he starts on the- degree of mortality caused by that disease, and on its spreading by contagion, can only be re- solved and removed by an exact knowledge of the facts. The dysentery, to which he was witness in Egypt, appears to him uniformly to arise from the suppression of perspiration, owing to the imprudence with which the soldiers exposed themselves, by sleeping in the cold and damp night air. He distinguishes it into three, degrees: the first consisting of ( 190 ) simple dysentery, without colic; the second accompanied by colic and mucous evacua- tions; and the third accompanied by fever, bilious, putrid, and bloody evacuations. In the treatment, varied according to the indications and circumstances, the author mentions the advantages obtained by means of opium, the utility, in certain cases, of blisters applied to the abdomen, and of the fruit called bao-bab, or monkey's bread (Adansonia bao-bab), much recommended by the native physicians. He recommends the practice of adding a little coffee, or brandy, to the Nile water, as a preserva- tive against this disease. Lastly, the ophthalmy, divided by the author into the simple and the complicated, that is to say, with swelling of the con- junctiva and palpebrae, violent pains and fever, and various organic lesions of the ball of the eye—the ophthalmy appeared to M. Assalini constantly produced by the influence of the cold night air, joined to the fatiguing effect of the burning heat and excessive light of the sun on the organ ( 191 ) of sight. The sands driven by the winds, and the saline substances with which they are impregnated, appeared to him to be only accessory influences, which may pos- sibly aggravate the effects, but which are subordinate to the principal cause: in short, that this disease, and the dysentery, in his opinion, only differ from each other in the -part affected, and are especially determined in proportion as the one or the other be- comes most irritated or enfeebled. The treatment of the ophthalmy presents nothing new. He reduces it to the em- ploying of means to produce revulsion, and of tonic and astringent collyriums, not for- getting to follow the indications presented by the several consecutive organic lesions. The remedies of the country are of little value, and the precautions for preventing the attack consist in being careful not to sleep in the open air, but particularly in the current of air from open windows ; and when on duty in the field, to keep the head covered, and protected with a cloak. ,M. Assalini concludes his work with the ( 192 ) plan of an hospital adapted to the country. It consists of a large building, the fronts look to the east and west, and the windows extend from the ceiling to the floor. The ends looking to the south and north are easily shut against these winds, so danger- ous in that country. There are likewise rooms adapted for stoves, oily frictions, for the reception of convalescents, and for other purposes. A wind-dial (rose de vents), communicating with a weather-cock, is plaeed in the ward, in order that the phy- sician may regulate the opening and shut- ting the windows, and ventilating the wards according to the weather. The building is terminated at top by an open terrace, adapted for a promenade during the time of the epidemic. There are likewise seve- ral other arrangements, well adapted to the necessary purposes of such a building. Such is the concise idea which we have thought fit to give here of M. Assalini's work. It remains for experience to decide the queries therein discussed on the subject of contagion; queries on which immediately ( 193 ) depends the theory of the preservative means, and of those proposed for the destroy- ing the source of the pestilence. However strong his reasoning may appear, before pro- nouncing judgment it behoves us to wait until the united observations of all those physicians who have observed the same phe- nomena as himself upon the same theatre, and at the same time, shall begin to dissipate our doubts, and to teach us whether or not the ancient opinions, consecrated by time, and the authority of the greatest names, ought to be ranked amongst those preju- dices which time destroys so slowly, but which the lights of philosophy and science ought at length to overturn. In supposing the decision perfectly con- formable to the observations of M. Assa- lini, and to the conclusions which he draws from them, there will still remain on the phenomenon of contagion, a great num- ber of other questions to be resolved: and when we not only consider the diversity of qpinion amongst the observers, but when we compare the facts with each other, and, S ( 194 ) at the same time, consider the phenomena of contagion in those diseases in which this property exists beyond a doubt, it may be asked, whether it may not be possible to imagine that the same disease mav not be more or less contagious, or even not at all so, according to circumstances,such as the violence of the epidemic, the state of the intervals of the contagion, and the particu- lar predispositions of those individuals who are attacked with it; predispositions which may have something both of an epidemic and also endemic tendency; so that a dis- ease exactly the same in its characteristic symptoms, shall perhaps have been re- marked at different times, and in different places, to be contagious or non-contagious, by observers of equal accuracy and inftnv mation? This is not a question of simple theory, or of pure curiosity. In pursuing this inquiry, the physician ought, without doubt, to be cool, and un- biassed by prejudice, or any foreign consi- deration; but he should also be persuaded of this very important truth, that if it be ( 195 ) useful in such cases to inspire individuals with confidence, it is no less important not to lull into a false security the solicitude of governments. Nevertheless, the work of M. Assalini appears to us to be important in its object; valuable from the collection of facts which it presents us, useful and judicious from the manner in which they are compared and discussed; and, without prejudging its ul- timate consequences, we think that it may contribute to diffuse information on a sub- ject become more interesting than ever, and which is thus submitted to the meditations of observers, and the attention of govern- ments. (Signed) Thouret and Halle, Commissioners. A true Copy, in the name of the Committee of Administration of the School of Medi- cine, the 24 th Ventose, in the year 9. (Signed) Thouret, Director. ( !96 ) REPORT Made to the Consuls of the French Republic, by the Minister of War, the 15 Germinal, Year 9 (Uh April, 1801J Minister of War has received such important details on the state of the hos- pitals of the army of the East, that he thinks it proper to submit the result to the inspec- tion of the Consuls. In Europe, during the war, the number of sick was to that of effective men as one to twelve; and before the revolution, during peace, the proportion was the same. In Egypt it has been, during the month of Brumaire (October and November), as one to twenty-eight; and during Frimaire (No- vember, December), as one to thirty In Europe, in the military hospitals, the number of deaths is to that of sick admitted The ( 197 ) during the month, as one to twenty-three. In Egypt, during the month of Brumaire, the proportion has commonly been as one to forty-three; and in Frimaire, as one to thirty-seven. The increase of deaths during this last month was owing to the contagious dis- cs o ease which, though little spread, was be- ginning to show itself. It is known that in Europe the number of sick is to the population as one to twenty, and that in a month the mortality is to the number of sick as one to nineteen ; so that the best established facts prove, that the climate of Egypt is already become to Frenchmen more healthy than their native country, or than any other country in Eu- rope : what then will it be when the sci- ences and arts shall have diffused all their advantages, and shall have banished from it its contagious diseases, and instructed us in the means of preventing the ophthalmy ? By making for those two months the number of daily reports of the sick in the hospitals of the army of the East equal to S2 ( 198 ) unity, we find that the daily reports have been, For febrile diseases - - 0.393 Wounded - - 0.187 Venereal - - 0.369 Contagious disease - 0.007 The ophthalmy - 0.044 1.000 You perceive, Citizen Consuls, the re- markable salubrity of this fine country, for* merly the cradle of the arts and sciences, which was the granary of Rome, which ought to be the emporium of commerce between India and Europe, and which is one of the theatres on which have been most signally displayed the spirit and bra- very of Frenchmen. (SignedJ Alex. Berthier, i 199 X ADDITIONAL NOTES, Page 71, line 11. ClTIZEN CERRESOLI, physician of the army of the East, in his journey from Cairo to Siout, speak* ing of the plague, says, that he never has been able to collect the information be wished for respecting this disease; but, after a great many accounts, he concludes, that the word plague, or koube'h in Arabic, is a generic denomination applied to acute and ma- lignant diseases.. Page 72, line the last. It is commonly asserted that the, heat in • Egypt puts a stop to the progress of the plague, whilst it makes it burst out at Constantinople.. How is this fact to be accounted for? The explanation is, in my opinion, very simple. At Constantinople the exhalations from various bodies in a state of putre- faction are very copious during summer: the cold «f winter prevents their, formation, and the disease ( 200 > ceases. In Egypt, on the contrary, the action of the sun is very powerful, even during winter, and gives rise to noxious exhalations, as we have proved elsewhere. When the, low grounds have become dry, which happens about the month of Messidor (in June, at the festival of St. John), then the coast of Lower Egypt becomes as healthy as the rest of that fine country. The environs of Modena were formerly subject to a class of diseases, which Torti has with justice denominated malignant fevers^ because they frequently carried off the patient during the third paroxysm, and even when considered out of danger. Debility, drowsiness, and excruciating head-ach, were the principal symptoms of these fevers ; between which and those of Egypt there exists a strong resemblance. At this day the malignant fevers of Torti have either disappeared altogether, or are become very rare. This change has been attributed to the filling up of the ditches and morasses which surround the city and citadel of Modena, the corrupting waters of which occasioned exhalations which infected the air. The celebrated Torti has taught us the mode of curing this disease as if by enchantment, by means of Peruvian bark, given in large doses, frequently repeated. I had an opportunity of seeing and treating this disease near Mantua: its course is so rapid, and its symptoms so violent, that in order to stop its pro- gress I was always obliged to give three ounces of ( 201 ) bark, mixed with wine or water, in the course of twenty-four hours, between one paroxysm and ano- ther; and when the patient was weak, I did not omit adding more or less of liquid laudanum, ac- cording to their state of constitution. Those physicians who, from a dread that this practice will overheat, or cause obstruction, prefer the use of refrigerants, or purgatives, in order to evacuate the bile, have constantly the mortification of seeing their patients carried off as if apoplectic, and in a very short time; and if they escape, after suffering from fever for several months, they at length become dcopsical, which they never fail to attribute to the bark, which they were too late in prescribing. Practitioners of experience, who treat this disease successfully, according to Torti's me- thod, agree, that these diseases may be cured with bark of a good quality, but not with powdered oak- bark, such a was furnished at one time to the mili- tary hospitals of the army of Italy; which was the real cause of the loss of many brave men, and of the disease frequently terminating in obstinate obstruc- tions. The physicians and apothecaries who did duty in the different hospitals for febrile diseases at Milan can attest the truth of this fact. Page 109, line the last. Change of place and air was often useful in the ,most obstinate cases of dysentery. ( 202 ) Citizens Livron, Pagliano, and Corance, attacked with a diarrhoea which would not give way to all the remedies which Citizen Desgenettes and myself had prescribed them, very soon recovered by removing from Cairo to Alexandria. A great many persons who had the dysentery very severely at Alexandria, got well by removing to Cairo. I remember Gene- ral Bessiere, who now commands the cavalry of the Consular Guards at Paris, so ill and pulled down at Cairo, that his life was thought in danger: he re* covered in a very short time at Giseh. Page 113, line 24. The hab-hab is the fruit of the bao-bab, or baho-bab, a tree of a monstrous size, which grows in Ethiopia and Senegal: by the natives of this island it is called goui, and its fruit boui; by the French callebassier, or gourd-tree, and its fruit pain de singe, or the monkey- bread. Adanson, after returning from Senegal, com- municated, in the year 1761, some very curious and interesting particulars respecting this tree, and its medical properties, to the Royal Academy of Sci- ences at Paris. As these are a good deal connected with the subject I have been just treating, it may not be amiss to give here the following particulars. The bao-bab, on a near view, looks more like a forest than a single tree. Its trunk is seldom more than ten or twelve feet high, but its circumference is generally from seventy-five to seventy-six feet and ( 203 ) a half. This immense trunk Is crowned by a great number of branches, remarkable on account of their size, but still more on account of their length, which varies from fifty to sixty feet. That branch which springs from its centre rises vertically, but those from its sides have generally a horizontal direction* These trees commonly have a great many roots, almost as large and numerous as their branches, but of a still greater length. Adanson saw one which measured one hundred and sixty feet long: it be- longed to a tree of the middling size. The leaves of the bao-bab are elliptical, pointed at the extremities, about five inches long, and one or two inches broad, of a moderate thickness, glossy, entire, having no serrated edges, the upper surface of a bright green, the under surface of a pale green colour, crossed obliquely by alternate nerves, rounded off, little elevated, and attached from three to seven together, upon a common foot stalk like a fan, pre- cisely like the horse-chesnut. The flowers of this tree, when in bud, form a globe of almost three inches in diameter; and on blowing become four inches in length, and one in breadth: two or three spring out from every branch, each suspended by a cylindrical peduncle, a foot long, and five lines thick. The xalix of each of these flowers is of a single piece, in the shape of a saucer, the edges of which are divided into five equal triangular portions: it is entirely covered with bairs of a whitish colour, and shining on the upper ( 204 ) surface, and green on the under surface; it falls off as soon as the fruit is set. The petals are five in number, within which arises a hollow cylinder, crowned with about seven hundred stamens, in the form of a ring, the filaments of which have on their summit small anthers, which, on bursting, throw out a whitish pollen. From the centre of the calix arises the pistil, the length of which a little exceeds that of the petals; it is composed of three parts, namely, an oyary, a style, and several stigmas. The ovary is egg-shaped, ending in a point, and entirely covered by thick shining hairs; its summit supports a very long cylindrical style, a little bent, hollow in- ternally, and crowned by ten or fourteen prismatic triangular bodies, pretty large and shaggy, called stigmas. The ovary of the flower of the bao-bab, on ripening, becomes a considerable fruit, of an egg- like shape, pointed at both ends, about a foot or a foot and a half long, and from four to six inches thick, suspended by a cylindrical peduncle, about two feet long, and more than one inch in diameter; its rind is woody, very hard, two or three lines thick, .and covered externally with a down composed of green hairs, which give it that colour. On rubbing off this down, it appears blackish, and strongly marked by ten or fourteen furrows, which run along its whole length like so many rays-: when we cut this fruit through, we discover in it ten or fourteen membranous partitions, of a reddish colour, and stringy texture, which divide it longitudinally from ( .263 ) top to bottom into as many cells, which are com- pletely filled with seeds : these partitions are attached to the inner walls of the woody rind, and are.joined together at the centre of the fruit, as round a com- mon axis, as long as it preserves its first moisture; but, on becoming dry, they separate widely apart, leaving a hollow at the centre. In this dry state they resemble a good deal, both in substance and shape, that part of the dura mater called the falx. The seeds, on opening the fruit, do not appear dis- tinct ; nothing is at first seen but a spongy substance, which is whitish in the sound fruits, and reddish in those which are ill formed, or very old. When the fruit is first ripe, this substance forms but one massi on account of the moisture which it still possesses; but on drying it becomes friable, and separates either of itself, or on the smallest shake, into a great many irregular polygons, each of which contains a blackish brown seed, glossy, kidney-shaped, about five lines long, and three lines thick, from the sinuosity of which arises a cord, or reddish filament, very long, which is attached horizontally, as to a placenta, into the inner edge of the partitions at the centre of the fruit. This tree sheds its leaves in the month of Novem- ber, and puts them forth anew in June, flowers in July, and in the months of October and November its fruits are quite ripe. With regard to the medical virtues of this tree, Adanson says, that the natives of Senegal dry the T ( 206 ) leaves in the shade, and then reduce them to pow- der, which powder they call lalo: they put two or three pinches of this into their food, in order to moderate the excessive heat of their blood, and keep up a plentiful perspiration, which preserves them in good health. Adanson asserts, that he himself was preserved from the fevers which he calls ardent, and which spread epidemically, attacking the natives of Senegal, and especially the Europeans, whom they carry off in great numbers, during the months of September and October; that is to say, on the sudden ceasing of the rains, when the sun begins to dry up the pools of water which are left on the ground. At this dan- gerous season Adanson made a weak tisan from the leaves of the bao-bab: this tisan is tasteless: when it is made very strong, it discovers a faint taste, which is easily corrected by adding a litttle sugar, or a little liquorice root. . Every year, during these two months only, he took half a pint of this decoc- tion in the morning, and the same quantity in the evening after the great heat. He likewise took it towards the middle of the day; but that was only when he felt some degree of head-ach, indicating the attack of fever. By this means he prevented, during a residence of five years in Senegal, the diarrhoeas and ardent fevers, which are almost the only diseases to be dreaded in that country. To display more strikingly the good effects of this tisan, taken during the critical season, he relates the following fact: C 207 ) " In the month of September, 1751, when the ardent fevers were raging more than had been remembered for several years past in Senegal, I continued," says Adanson, " my fatiguing excursions a hunting and botanising, with as much eagerness as I could have done at home; and one of my friends who followed my example, in using the tisan, was the only one besides myself who pursued his usual occupations, whilst all the other French officers were confined to bed, a circumstance which surprised them much, particularly as to my friend, whose very delicate constitution appeared more susceptible of the im- pressions of bad air, which was believed to be the chief cause of the epidemic diseases of this season. A remedy so innocent, so simple, and from which I experienced such good effects, ought to be employed during this season, to prevent not only these burning fevers, but also the ardor urince, which is very com- mon during the sickly season; that is to say, from the month of July till the month of November. Ex- perience has convinced me, that this tisan alone is sufficient, provided wine is abstained from." The fruit of the bao-bab is of no less use than the leaves we have just mentioned ; they eat the fungous pulp surrounding the seeds; it has a sourish taste, rather pleasant, particularly in the fruits of that year, which are still in some degree fresh. In time this fruit loses considerably in its good qualities; never- theless, it is exported from Senegal to the neigh- ( 208 ) bouring nations in the kingdom of Morocco, and in Egypt. Prosper Alpinus says, that this fruit is brought to Cairo in so dry a state, that its pulp can be reduced into a powder, which is there called earth of Lemnos. It is generally used in pestilential fevers, in spittings of blood, the lientery, dysentery, and hepatirrhcea: it is likewise used to moderate the menstrual dis- charge. The dose of this powder passed through a fine sieve, is one drachm: the physicians prescribe it for the sick above-mentioned, and make them take it either in solution in the plantain water, or in in- fusion or decoction in common water. Prosper Al- pinus is the first botanist who has mentioned this tree, and he has given the following description of its fruit: o " Bao-bab est fructus magnitudine mali citri, cu- curbits similis, intus semina nigra, dura, extremis in unum seminarium quasi inclinantibus, et substan- tiam cucurbitarum similcm habent, quse in recenti- bus est humida, rubra, sapore acido non ingrato fructus recenter ab arbore exscissus, gustui admo« dum gratus est: valentes extinguit multumque re- frigerat, febresque omnes putridas, prsecipueque pes- tilentes sanat. Cairi habitatores fructum in pulve- rem reddunt, quse terra Lemnos appellatur; estque apud multos familiarissimus illius ce terrae usus ad pestiferas febres, turn ad sputum sanguinis, ad lien- terias, dysenteriam, cruentumque hepaticumfluorem, ( 209 ) necnon ad uteri menses firmandos. Alii hujusce terra; in subtilissimum pulverem redacts drachmam cum aqua plantaginis dissolutam exhibent, alii de- cocto, alii infuso iitentis." See Alpinus Des Plantis Egypt i. In the Jardin des Plantes at Paris there are seve- ral specimens of the fruit of the bao-bab, in very good preservation. The celebrated Jussieu pointed out to me a covering on the outside of the green ( 227 ) through the human frame, begets a poison sui ge- neris, which may be conveyed from one person to produce the disorder in another. The contagious or infectious fever which pro- ceeds from distempered human exhalations is a distinct maladv. The yellow fever has a different origin—is different in its svmptoms—and requires a different mode of treatment. They both have their different degrees, and the mild typhus, and typhus gravior of England are not more alike than the continued and the remittent fever of the West- Indies. Perhaps the mild and the confluent small- pox are more unlike: yet no one denies that either is small-pox—nor doubts that both are derived from the same cause—the same specific virus. If the medical attendants, and the (white) order- lies, who have been employed in the hospitals, have suffered from the fever; still they have only suffered in common with the officers and soldiers, who have not been quartered near the hospitals ; and, as their proportion of duty and fatigue has been uncom- monlv great, it were not to be expected that they could escape better than their comrades. But I have said that this fever does not attack the blacks of the West-Indies: I may, therefore, mention a remarkable fact, which, more than all others, would seem to militate against the doctrine of the yellow fever being, originally, a contagious, or becoming, in the course of its progress, an in- fectious malady, viz. that, of the multitudes of ( 228 ) black men and women whom I have had occasion to see employed constantly in the hospitals, and who have executed all the menial duties about the sick, the dying, and the dead, I never yet knew even a single instance of any one of them, either male or female, taking the disease. Perhaps no one will contend that this would have happened had the hospitals been equally crowded with patients in small-pox, measles, scarlet fever, the common jail fever, or any complaint decidedly infectious.* The yellow fever prevails most commonly, and most extensively, at the decline of the wet season of the year, when the rains and the sun irregularly alternate, and cause unsettled weather; and this is also the period when the bilious remittent, and the ague appear among the Creoles and negroes. In the midst, or at the very height of the wet season, and during the finer dry season, the fever, in all its * In the year 1793, a body of emigrants from St. Domingo, amounting to upwards of SCO in number, who had made their escape from that colony, under all the circumstances of the most afflicting depression, arrived at Philadelphia, at the time when the yellow fever raged with its utmost malignity: yet, not one of them was attacked with the afflicting malady which was then desolating the town. And, as if expressly to make this fact the more striking, it likewise happened that the emigrants who arrived at the same distressing period from Ireland, the States of Germany, and other parts of Europe, were attacked by the fever, even in greater proportion than the Americans themselves.—It is not the property of any con- tagion to exhibit such marked partialities The autumn tem- perature of Philadelphia was .congenial to the emigrants from St. Domingo: they were acclimates, and therefore not suscep- tible of the disease ; while those from Europe, being the in- habitants of colder regions, were in a peculiar degree predis- posed. ( 229 ) shapes, is far less common: likewise in the dry and elevated parts of the country, which are open to the breeze, it is out of all proportion less frequent than in low damp situations, in the vallies, and about the openings of the rivers. In North-Ame- rica it is principally, nay almost exclusively a dis- ease of the low and crowded towns, situated upon the borders of the rivers, and the bays of the sea; and is scarcely known in the higher, or more inte- rior parts of the country. The great favouring circumstances, therefore, appear to be a high degree of temperature, and a moist state of the atmosphere ; to which may, per- haps, be added the ill chosen situation of the towns: but, from the particular season in which it spreads its ravages, and from all the host of concomitances, it would seem that we are to regard some miasma, or unwholesome exhalation, as the true pabulum of the disease. At the high period of the wet season the ditches and canals are full, and the brooks and rivulets fluent, so that the noxious exhalations are neither so readily formed, nor so easily taken up into the atmosphere : and, in the dry season, these deadly vapours are either chased away by the breeze, or rendered effete by the intense rays of the sun—but during the intermediate period, at the decline of the wet season, every circumstance tends to favour their production, and to promote their diffusioa and suspension in the surrounding air. X ( 230 ') The fever is most readily generated in new cols- nies, where the land is only partially cleared of its wood, badly cultivated, and the half-drained soil left to exhale its noxious vapours into the surround- ing atmosphere. In the older colonies, where the forests have been long cut down, the land brought under general cultivation, and its surface more opened to the breeze, it is found to be less prevalent. Examples of this are seen in the old islands of Barbadoes and Antigua, contrasted with those of Grenada and Trinidad. The former are well cleared, and universally tilled, and from situ- ation, as well as culture, freely exposed to the in- fluence of the trade wind;—in these, the disease but very seldom appears. The latter are not yet brought under general cultivation, but are partially covered with wood, and the atmosphere is damper, and less purified by the breeze:-—here, the fever frequently and fatally rages. In new settlements where the land is recently brought into cultivation, and not well cleared of drained, and particularly in the vicinity of the towns or habitations, which are commonly placed at the lowest and most insalubrious spots, for the tonvenience of commerce, the drainings of the higher lands, and often the filth of rivers, or of ha} s and inlets of the ocean, together with decayed leaves, plants, and roots, and, in short, the whole exuvice of the vegetable world collect, remain, and grow putrid, and, in such situations, the very ( 231 ) weeds and coarser plants become rank and exu? berant, and, growing up only to decay, add to the fermenting mass, which, by holding the impure waters stagnant, accumulates and creates a noxious swamp ; and thus is generated the hideous Python who, though often conquered by the darting rays of Apollo, again uplifts his deadly front, and can only be subdued by the more steady and persevering in., dustry of man* Wnen the effect of climate and situation shall be fully understood, and duly estimated, the yellow fever may be no longer the scourge of our mer- chants, or planters, and our armies: yet, after the long and fatal experience the world has had, it is equally lamentable and surprising that men should still blindly continue in error, with respect to the situations chosen for their towns and dwellings. Contrary to their better knowledge, they prefer the convenience of commerce to the more import- ant advantages of health, and fix their habitations, as it were expressly, upon the most unhealthy points of the globe. In every nation, and almost every colony, striking examples might be selected of the strange folly and neglect with which we regard a circumstance of such serious magnitude. Armies, perishing with fever, or dysentery, have been snatched from threatened destruction, by change of situation; and countries, almost m.-riting the reproachful term pestilential, have been rendered salubrious by attentions to the soil; still, on the ( 232 ) score of health, much remains to be done, by manr kind fixing their residence where the atmosphere is least exposed to noxious exhalations. But, alas ! commerce, and her prostitute suite, riches, dissi- pation, and luxury, deafen the loud calls of the fair Hygeia, with her more virtuous train, ease, tranquillity and happiness ; and while man remains ambitious, and wealth be made the public road to honours and distinctions in society, health will con- tinue to be only a secondary object of his consider- ation. It is in the province of the physician to ex- pose this fatal error—to philosophy it belongs to .remove it. I woidd remark that the fever of these regions seems, in many respects, to be governed by the same circumstances as the endemic fever of Kent and Lincolnshire, in England, and, indeed, when it attacks the natives of the country, it even assumes the same type and symptoms : and I much suspect that if it could happen that the temperature of these provinces should continue as high as from 80° to 90° during the summer, and heavy rains should fall in July, you would have yellow fever in the months of August and September: but, while die general heat of the summer shall continue below 70°, there can be no fear of yellow fever being generated in England— Cavallo on Electricity, Celsus of Medicine, Chaptal's Chemistry, Chemical Pocket Book, Chemical Vocabulary, Chisholm on. 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