CORRECTED PRESCRIPTIONS FOR PHARMACY TECHNICIANS COMPILED AND PUBLISHED AT THE MEDICAL DEPARTMENT ENLISTED TECHNICIANS SCHOOL (.LETTERMAN GENERAL HOSPITAL SAN FRANCISCO, CALIF. 1942 FOR THE USE OF STUDENTS. Rx Hydrargyrum Chloridum Corrosivum 0.75 Sacchari 2.00 M. FT. Chart, vi Sig, - One at night. 1. Form; The nominative form of the title is incorrect. It should read "HYDRARGYRI CHLORIDI CORROSIVI". "Sacchari" is an old form. The official title is SUCROSUM, In the inscription it would be in the genetive SUCROSI. 2. The proscription as written is intelligible. 3. Dosage: Tliis dose of bichloride is excessive, and would probably prove fatal, A dose this size of mild chloride of mercury night conceivably be given. This is what is intended, here. 4. There are no incompatibilities except the excessive dose. ) 5. Corrected Prescription: Rx Hydrargyri Chloridi Ilitis 0,75 Sucrosl 2.00 K, ft. Cha.rt. vi. Sig. - One at night. 1a Rx Oloi Terebinthinae Roc. Aquae Distillatae qs. Hi see secimdem arten Sig. - One tcaspoonful three times a day. Form: Satisfactory. Ambiguity; None. Dosage; Proper. In c ompatibili ty; The prescription would present an incompatibility but for the dir- ections to the compounder. An emulsion is clearly intended. The emulsion is best made with 5 gm, of acacia. Place the Oil of Turpentine into a perfectly dry bottle, add the Acacia and mix well. Then add exactly 10 cc. of water and agitate till an emulsion is formed. Gr a dully add the remin- der of the water, agitating after each addition. Corrected Prescription: 2a Rx Acidi Boracici 5.0 Aquae Distillatae 60,0 M. Ft. Collyr. Sig. - Tvro drops in each eye every hour. Form: Satisfactory, Ambiguity; Acidi Boracici is probably satisfactory yet would be more properly written as Acidun Boricun. Dosage: Proper. Incompatibility: There is too much acid to dissolve in the amount of water present. A saturated solution should be prepared by filtering out the excess. If crystals of the acid arc used, filtration is easier. Corrected Prescription; 3a Rx. Calcii Lact. 15.0 Aq. Month. Pip Q. S. 60.0 M ft. Sol. Si": 2 cc at mealtime. Pom; Satisfactory. Official abbreviations and doses of active ingredients per dose: Calc. Lact. The dose of Calcium Lactate is satisfactory. Therapeutic Value: Treatment of Calcium deficiency. Inc ompatabili ty: Calcium Lactate is soluble 1 Gm. in 20 cc of water, therefore, a mixture mil have to be. prepared and dispensed as such. To heat the mixture will form a gelatinous mass. Calcium Lactate is not on the supply table, therefore, when asked to compound such a prescription ask the doctor to permit the substitution of Calcium Gluconate. The dose in this case should be altered to about five times that of Calcium Lactate. Method of Compounding: Place the Calcium Gluconate or Lactate in mortar and triturate with a snail amount of water until a paste is formed - then q.s. to 60 cc and dispense with "shake well" lablc. 4a Rx -xid Nltrorauriat. Dil. 30 Spir. Annonii Aron. 30 ti r 1 Gig. Two (2) drops in water every two (2) hours. Form: Latin and English in First ingredient. Latin would be Acidi Nitro- muriatic! Diluti, or more nodcrnly, Acidun Nitrohydrochloricuri Dilutun. Amncnii is incorrect; should be ammoniac-, or Sp. Ammon. Aron. Ambiguity: None. Dosage: Dosage is rather minute. Probably for a very small child. Incompatibility: Chemical The Airnioniun carbonate of the spirit is neutralized hj the acid, probably completely, with the formation of anirsoniuri chloride and ammonium nitrate. Pharmaceutical 'Hie aromatic oils of the spirit are precipitated by the addition of the dilute acid which, of course, is aqueous. There is no way to prevent or correct these incompatibilities. Hie preparations should ho dispensed and administered separately. Corrected Pr e scr ip ti on: Rx Acid Nitrohydrochlor. Dil. 30 Sp. Aranon. Aron. 30 x xm Gig. Two drops in water every two hours. 5a Rx Hydrargyri Protoiodidi 1.0 Potasbii lodidi 10.0 Tincturae Cardarriorii Compcsitae q.s. 90.0 M X'-’X • Sig. 4 cc c.i.d. Form: Satisfactory. Ambiguity: None. Dosage: Dosage v/ould be satisfactory if the ingredients remained as they are written. In the excess of iodide, however, the protoiodide is gradually changed to mercuric (red) iodide, the dose of which is much smaller. In c ompa tib ili ty: As stated above, the mercurous iodide is oxided to mercuric iodide. As the amount present would make a dangerous mixture the preparation should not be dispensed. Corrected Prescription: 6a Rx Extracti Nucis Vomicae Pulverati 0.015 Extract! Digitalis 0.015 Sacchari Lactis q.s. Mi see et fiat capsulae numero xxiv Sig, One capsule three (3) tines a day. Form; Satisfactory. Ambiguity: None. Dosage: The dose is very small, 0.015/24 or 0.0006 gm. of each extract per capsule. In a case of this kind, where the amount of each drug in the whole prescription is almost exactly an average adult dose, the question arises whether or not the amount written is intended for each dose. In the above prescription, this was intended. Inc onpatibili ty: Only the dosage. Corrected Prescription: Rx Extract! Nucis Vomicae Pulverati 0.015 Extract! Digitalis 0.015 Sacchari Lactis q.s. Misce et fiat tales capsulae nuraero xxiv Sig. One capsule three tines a day. 7a Rx Sodii Citratis Sp. Aetheris Nitrosi aa Syr. Aquae aa liisce secundera artem Sig. 4 cc. q. 4h. Form; Satisfactory. The former name for spirit of ethyl nitrite is used. Ambiguity; None. Dosage: Satisfactory. Incompatibility; The prescription presents a perfect case of salting out. The rather concentrated solution of sodium citrate throws out a solution the ethyl nitrite, which if ■warn, rapidly volatilises. There are several remedies. The obvious one would be to increase the volume, and the dose correspondingly. Probably the easiest solution, however, is to add 5 to 10 gm, of acacia to the preparation before adding the niter. Corrected Prescription; Rx Sodii Citratis Sp. Aeth. Nitrit. aa -h-caciae Syr. Tolu Aquas q.s. M. ft. mist. Sig. 4 cc p.c. OR Rx Sodii Citratis Sp. Aeth. Nitrit. aa Syrupi Tolu Aquae q.s. ii m 11 • SOl • Sig. 05 cc Lable: One teaspoonful ffelsv- 8a Rx Acidi Carbolic! 7.5 Aquae 22.5 M. et Sig. Apply with a brush. Form: The name acidi carbolici while not incorrect is less preferable from any standpoint to the present title. Ambiguity: None. Dosage; See incompatibility. Incompatibility: There is more phenol in the mixture than will dissolve. If dispensed as written the heavier phenol will settle to the bottom. If fresh this would not be easily noticed and the last portions of the liquid would be nearly pure phenol. The remedy is to mix the phenol first with an equal volume of glycerin, when it is perfectly soluble. Corrected Prescription Rx Phenolis 7.5 Glycerini 7.5 Aquae 15.0 M. Sig. Apply with a brush. 9a Rx Potass, Chlorat Ac. Hydrochior. Aquae Dost. q.s. M. S. A. as directed for throat. Form Satisfactory. Lable should be corrected to read - in cups of warm water as a gargle. Official abbreviations and doses of active ingredient Doses satisfactory. Therapeutic value: Antiseptic. Incompatibility; None Method of Compounding; This solution is very similar to one formerly official as compound solution of chlorine. Depending upon the manner in which it is mixed, two rather different preparations are obtained. If the chlorate is dissolved in water (almost all of it will dissolve) and the acid added last, the reaction takes place only slowly and incompletely. The intention is to place the chlorate in a larger bottle (200 cc) add the acid and close the bottle loosely with a funnel stoppered with moistened cotton. When the reaction is almost completed (no more effervescence) water is added through the funnel and the bottle agitated until no more chlorine will dissolve. The solution is then transferred to a 50 cc bottle. Needless to say that the solutions should all be cold. 10a Rx Quinine Sulfate 2 Potass. Acetate 8 Arom. Sulf.Acid. 2 Aq. Dest. qs 30. M. Sig. Teaspoonful before meals. Form: Aq. Dest. is the only ingredient written in Latin. The subscription is also a Latin abbreviation. Otherwise the prescription is written in English. Official abbreviations and doses of each ingredient: Quin. Sulf. .25 Gn. Pot.Acet. 1.00 Gn, Acid,Sulfuric.Arom, .25 cc. Aq, Dest. Inc ompa tibility; Quinine acetate is precipitated. Method of compounding: There is no way to avoid, the precipitate save dispensing the pot. acet. in a separate solution. Nor can a suspending agent be used in the very acid liquid. Mix the quinine sulfate and aromatic sulfuric acid and add half the water. Dissolve the potassium acetate in the other half of the water and add it to the first solution. Corrected Prescription: Lable: No. 12 Dr. SHAKE VffiLL BEFORE USING. One (l) teaspoonful before meals. For Jan. 32,1330. Rx Quine ine Sulfate 2 cc. Potassium Acetate 8 cc. Aromatic Sulfuric Acid 2 cc. Distilled Viator to. make 30 cc. Mix them. Lable- Teaspoonful before meals. 12a PRESCRIPTION STUDY Rx Tincturae Ferri Chloridum Liquoris Ammoniac Acetas Ammonii Carbonate- Syrup i Aurantii Aquae qs I'd.see ft, mist. 12. 15. 2. 30. 240. Sig. 4 cc. A.M, and P.K, Form and ambiguities: All ingredients should be written in the genitive case, as follows: ... Chloridi,...Acetatis,...Carbonatis. Latin genitive for ammonium is ammonii not ammoniac. Hie prescription is not ambiguous. U.S.P. or N.F. Atoreviation and dose of each ingredient Tr. Forr. Chlor. 0.2 cc/dose Liq. Ammon. Acet. 0.25 cc/dose Ammon. Garb. 0.03 cc/dose Syr. Aurant. 0.5 cc/dose 0,2 cc/dose Incompatibilities: (Include excessive dosage if any) Ammonium Carbonate precipitates the iron as basic carbonate and oxide. Ammonium Carbonate reacts with acid of the syrup to liberate COg. It is probable also that in the concentrations present, iron will be also precipitated by the citrates present in the syrup. Method of compounding: If physician vd.ll consent, the use of tincture of ferric citrochloride will eliminate most of the difficulty. The carbonate-acid reaction impairs the taste of the prescription, but is harmless. The amount of citric acid present will not appreciably affect the dose of ammonium carbonate. Nothing would bo done about it normally. If it is infeasible to use the citrochloride tincture, 0.5 gm. of tragacanth would suspend the iron oxide, which, however, is inert. Corrected Prescription Rx Tincturac Fcrri Chloridi 12. Liquoris Ammonii Acetatis 15. Ammonii Carbonatis 2, Syrupi Aurantii 50. Aquae qs 240. Misee ft. mist. Sig. 4 cc, morning and evening. 13a PRESCRIPTION STUDY Rx Zinci Oxidi 3. Lin. Cal. qs.6o. M. Sig. Apply locally. Form and ambiquity: Lin. be either linimentum calcis or linimentum calaminae out or at least the N.F. abbreviation used. Interpret.a-tiorT'woulid' be- difficult, here. Linimentum calcis is more the linimentum calaminae already contains the oxide. U.S.P. Abbreviation of each ingredient Zinc. Oxid. Lirf, Caleb Incompatibilities; The zinc oxide breaks down the emulsion, completely, into the water and oil. The preparation is quite unsightly. Method of preparation: If the zinc oxide is triturated with 30 cc. of lime water and the suspension placed into the container, then the linseed oil (30 cc.) added and the whole mixture agitated, a creamy mixture results. Corrected Prescription: Rx Zinci Oxidi 8. Linimenti Calcis qs 60. M. Sig. Apply locally. 14a PRESCRIPTION STUDY Rx Liq. Pot. Cit. Sp. Nit. Aeth. Syr. aa 30.0 Tr. Aconite 30. M. Sig. Tablespoonful t.d. Form and ambiguity: Not all of the abbreviations used are the official ones, but those used are clear to the compounder. The prescription is a mixture of Latin and English. T.d. while not frequently encountered, is cometimes used, for t.i.d. U.S.P. or N.F. abbreviation and dose of each ingredient: Liq. Pot. Cit. 4 cc/dose Sp. Aeth. Nitrit. 4 cc/dose Syr. not abbreviated 4 cc/dose Tr. Aconit. 4 cc/dose Incompatibilities (including any excessive dosage): The dose of the tincture of aconite is too large and the mixture should not be dispensed as written. Method of compounding; The physician should be consulted regarding the dose. There are two possibilities for explaining the error: first that 3.0 should have been written; second that the directions should have been - Teaspoonful t.d. The large but not excessive dose of spirit of ethyl nitrite suggests the latter. Corrected Prescription Rx Liquoris Potassii Citratis Spirit! Aethylis Nitritis Syrupi Tincturae Aconiti aa 30.0 M, Sig, Teaspoonful three times a day. 15a PRESCRIPTION STUDY Rx Acidi Acetylsalicylici 2.0 Codeinae 0.4 Aminopyrinae 2.0 M, et div. in chart, cerat. vi Sig. One powder at night. Form and ambiguity: The form of the prescription is satisfactory and what is meant is clear. Official abbreviation and dose of each ingredient; Acid. Acetylsal. 0.3 Gm./dose Coriein. 0.07 Gm./dose Aminopyrin. 0.3 Gm./dose Incompatibility (including any excessive dosage): The dose of codeine is quite large and in addition the acetylsali- cylic acid has a synergistic action. However, the directions are one pow- der a day. This is a prescription requiring tact on the part of the com- pounder, for unless something was known of the habits of the prescriber anc the patient, the dose should be checked. Method of compounding; Triturate the drugs together and weigh-out 1/6 of the mixed drugs into each waxed paper. Corrected Prescription; The prescription is correct as written. 16a PRESCRIPTION STUDY Rx Saturated Solution of Potassium lodide 30 Sig. gtt. xas directed. Form and ambiguity: Form satisfactory. No ambiguity. (it is not necessary to write the ingredients in Latin.) Official abbreviation and dose of each active ingredient: Liq. Pot. lodid. 10 drops/dose Approximately 0.6 Gm. of KI per dose. Incompatibility (including excessive dosage, if any) None. Method of compounding: Dispense the N.F. solution or prepare the solution as directed in the N.F. Corrected Prescription; Correct as written. 17a PRESCRIPTION STUDY Rx Pernang, of Potash 2 Glycerin 30 M. ft. sol. Sig. For local application. Form and ambiguity; The form of the prescription is satisfactory, although an old form of the title potassium permanganate is used. The prescription is written in English except for the subscription. Official abbreviation of each ingredient; Pot. Permang. Glycerin. Incompatability; Glycerin is oxided by the permanganate more or less rapidly according to the concentration. If the permanganate is first powdered by trituration, and a small amount of glycerin added, the mixture will take fire. If a larger amount of glycerin is added the reaction will proceed more slowly with only the generation of heat. In any case, practically all of the permanganate will be decomposed in a very short time. The preparation is utterly useless. Method of compounding; Not to be compounded. Corrected Prescription; 18a PRESCRIPTION STUDY Rx Cocainae Kur, Argenti Nitras Aquae Best. qs. Ft. collyr, Sig. Apply to the eyes as required. Form; Cocainae Murias is an old name for Cocainae Hydrochloridum. Nitras should be nitratis, a genitive. No ambiguity. Official abbreviation and dose of each active ingredient: Cocain. Hydrochlor, No dose is given. The solution would contain Arg, Nitras (Nitrat.) 1% of cocaine and 1/6% of silver nitrate. Aq. Best. One could reason that a dose of up to five drops into the eye would be safe, depending upon the frequency. Incompatibility (including excessive dosage if any): Silver nitrate is precipitated by chlorides. The silver would all be precipitated in a short time, leaving the cocaine in solution as the nitrate. Method of compounding: There are several possibilities, but in any case, the precipitate in the collyrium would not be desired. If cocaine (alkaloid) is available it should be used, along with just sufficient nitric acid (diluted) to dissolve it in the water prescribed. Then add the silver nitrate to the solution. Another alternative is to prepare the mixture as written, warm on the water bath to insure complete precipitation, and filter the mixture until perfectly cool. A third possibility would be to dispense the solutions separately, with directions to alternate the use of them. The first and third methods would require the consent of the doctor. Corrected Prescription; Rx Cocainae Hydrochioridi Argenti Nitratis Aquae Destillatae qs Ft. Collyr. 19a Rx Syr. Ferri lodidi 10,0 Pot. lodide 10.0 Aq, Dost, 10.0 Sig. gtt XV t.i.d. Form: Satisfactory. To make it more convenient to calculate dosage tho prescription could have been written for a definite total amount. Dose of Active Ingredient per dose: Satisfactory, To determine the exact dosage, the prescription will have to be compounded to find the total volume. Therapeutic Value: Alternative. Incompatibility: If there are any ferric salts in the syrups the lodine will be liberated. This is a very unstable preparation, therefore a few drops of Diluted Hypophosphorous Acid may be used to keep the ferrous iodide reduced. Method of Compounding; Combine the KI. with the water and incorporate the syrup of ferrous iodide. Directions: Take 15 drops three times a day. 20a Rx Strychninae Sulfatis 0.06 Potassii Bromidi 5.00 Aquae qs 120.00 Ft, sol. Sig. 4 cc. a.c. Form and Ambiguity; None. Official Abbreviation and dose of each active ingredient: Strych•Sulf. 0,002 Pot.Brom. 0.17 Incompatibility (including any excessive dosage): Strychnine would be precipitated by the bromide. Strychnine and bromides are therapeutically opposite but that is the concern of the prescribcr. Method of compounding: Dissolve the strychnine sulfate in a mixture of 30 cc of alcohol and 60 cc of water. Dissolve the bromide in about 25 cc of water, mix the two solutions and add water up to 120 cc. Corrected Prescription: Lable: Rx Strychninae Sulfatis 0.06 Potassii Bromidi 5.00 Alcoholis 30.00 Aquae qs 120.00 Ft. Sol. 21 Dr . One (1) teaspoonful before meals. For Jan, 32,1340 Sig, 4 cc. a. c. 21 Rx Soda Bicarb. 3 Ac. Acetylsal. 3 M. ft. chart xv. Sig. 1 q 4 h. Form and ambiguity: There is no doubt as to what is meant. Soda Bicarb, is an old name. Official abbreviation and dose of each active ingredient Sod. Bicarb, 0,2 Acid.Acetylsal, 0.2 Incompatibility: Sodium bicarbonate and aspirin react to form sodium acetate and salicylate, water and CO*?, Method of compounding The best thing to do would bo to dispense the drugs separately, but this always creates a doubt in the patient's mind. The next best thing to do is to mix the sodium bicarbonate with about 10 Gm. of some non absorbent substance such as starch or kaolin thoroughly by tritur- ation. The aspirin should then be separately powdered and mixed into the first mixture on a paper or with a spatula. The patient should be cautioned to keep the powders in a dry place. Corrected Prescription: Lable. 22 Dr. Keep in a Dry Place One (l) powder every four (4) hours. For Jan.32,1940. Rx Sodii Bicarbonatis 3. Acidi Acetylsalicylici 3. Amyli 10. M. ft. chart, xv Sig. 1 q 4 h 22 Rx Hydr ar g. Chior, Tr. Cinch. Co. Arom. Sp. Ammon, qs M. ft. mist. Sig. 4 cc. q.i.d.a.c. Form and ambiguity The prescription is written partly in Latin partly in English, There is doubt as to whether mercurous chloride is meant. In view of the directions, however, the use of mercuric chloride is justified. It is not likely that such a dose of mercurous chloride would be given 4 times daily for 15 days. Official abbreviation and dose of each active ingredient: Hydrarg.Bi chlor. Tr .Cs.nch.Co. Sp,Ammon.Arom. Incompatibility (including any excessive dosage); Either mercurous or mercuric chloride is incompatible with ammonium hydroxide and carbonate. Mercurous chloride precipitates as black mer- curous oxide and amino compounds. Mercuric compounds precipitate as am- monia ted mercury. Method of compounding: The prescription should not be compounded unless the Aromatic spirit of Ammonia is dispensed separately. Mercury precipitates are too heavy to take chances with or attempt to suspend with gums. The mercuric chloride should be dissolved in a little water before it is added to the tincture. Corrected Prescription: Lable: 23 Dr. Shake Well Before Using. One (l) teaspoonful four times a day, before meals. For Jan. 32,1940. Rx Hydrarg.Bichlor. Tr. Cinch. Co. qs M. ft, mist. Sig. 4 cc q.i.d.a.c. 23 Rx Ammon. Carb. 15 Pulv. Ipecac 15 Syr. Scillae 30 Syr. Pruni Virg.qs. 120 Ft. Sol. Sig. 4 cc omnia 3 hora. Form and ambiguity: There is no ambiguity and the form is satisfactory, except that the prescription, if compound as written, cannot possibly result in a solu- tion. Official abbreviation and dose of each active ingredient Ammon. Carb. 0,5 Ipecac. 0,5 Syr. Scill. 1.0 Syr. Prim. Virg, 3.0 (approx.) Incompatibility; The first thing to consider is the dosage. The dose of ammon. carb. is large, that of ipecac is excessive, and the prescription would almost surely produce emesis at each dose. The mixture is clearly a cough preparation and no more than an expectorant dose of ipecac would likely be intended. It was found in this case, that the prescription had been transposed to the metric from the apothecaries system, and that in each of the first two ingredients, a half drachm had been mistaken for a half ounce, and this amount transposed. The amounts of ammon, carb. and ipecac should each have been 2.0 Gm. Apart from the dosage, the ammonium carbonate reacts with the acid in the syrup of squill and slowly effervesces. The powdered squill in the preparation is mostly insoluble and must be shaken to suspend it before each dose is taken. Method of Compounding: Triturate the ammonium carbonate to a fine powder, add the syrup of squill and stir until effervescence ceases. Finely powder the ipecac and mix it thoroughly with the syrup of wild cherry. Mix the two liquids. If permission can be obtained, the use of fluidextract of ipecac would make a much better preparation. If used it should be added to the ammon, carb.-syr. squill mixture before adding the syrup of wild cherry. Corrected Prescription: Rx Ammon, Garb. 2 Pulv. Ipecac 2 Syr. Scill. 30 Syr. Prim. Virg, qs 120. Ft. Mist. Lable 24 Dr .-JHHHHHHHHHHHHH* Shake Well. Teaspoonful every three (3) hours. For Jan. 32,1940, 24a Rx Plumbi Acetatis 2.0 Aluminis 1,0 Aquae Rosae qs 120.0 M. ft. lotio. Sig, Use externally as directed. Form and ambiguity: The prescription is clear and the form satisfactory. Official abbreviation and dose of each active ingredient; Plumb, Acet, Alum. Aq. Ros. the lotion is for external use - no dose. Incompatibility; Insoluble lead sulfate is formed in the lotion. Experience would show that the precipitation is intended in the preparation. The final lotion contains in solution; lead acetate, aluminum acetate, ammonium or potassium acetate (depending upon whether ammonium or potassium alum was used)j in suspension, lead sulfate. Method of compounding; Dissolve the lead acetate in half of the rose water, and the alum in the other half. Mix the two solutions with strong agitation. This method produces the precipitate in as fine a form as is possible. No gum or suspending agent would be soluble in the lead acetate solution. The use of such a substance vrould make a worse preparation. Corrected Prescription: As above. Lable: 25 FOR EXTERNAL USE ONLY Shake well and use externally as directed. For Jan. 52, 1940. 25a Rx Sodium Salicylate 5.0 Glycerol 3.0 01, Gaulth, Mi Tr. Ferric Chloride 3,0 Citric Acid 0.3 Liq. Ammon. Acetate qs 60.0 Ft. Sig, 8 cc 2 or 3 times a day. Form and ambiguity: There is no ambiguity but the prescription is written in a mixture of Latin and English, and in metric and apothecaries measures. For complete English-metric prescription, see below. Glycerol is an official synonym for glycerin. The use of fiat as an intransitive form is questionable. Official abbreviation and dose of each active ingredient' Sod. Salicyl. 0,6 Glycerin, 0,4 Methyl.Sali cyl. 0.008 Tr.Ferr.Chlor, 0.4 Acid.Cit, 0.04 Liq.Ammon.Acet. 6,0 (approx.) In c ompa tibili ty: Iron salts form purple compounds with sodium and methyl salicylate, and red compounds with ammonium acetate. Which of these colors will predominate will depend on the order of mixing. Method of compounding: Purple solution: Dissolve the citric acid in the tincture and add the glycerin. Dissolve the sodium salicylate in this solution and add the solution of ammonium acetate. Red Solution: Dissolve the citric acid in the solution of ammonium acetate, then add the tincture of ferric chloride. Dissolve the glycerin and the sodium salicylate in the mixture. In either case the methyl salicylate should be first dissolved in the tincture of iron. The order of mixing should be noted in detail on the prescription and followed closely in the event that the prescription is refilled. Corrected Prescription: Rx Sodium Salicylate 5.0 Glycerin 3.0 Methyl Salicylate 0.06 Tincture of Ferric Chloride 3.0 Citric Acid 0,3 Solution of Ammonium Acetate qs 60,0 Mix. Sig, 8 cc, 2 or 3 times a day. Lable: 26 Dr , *hhhh******* Dessertspoonful two or three times For Jan. 32,1940. 26a Rx Calcii Bronidi Sodii Salicylatis Aquae qs 6 M. et ft. sol Sig, Cochleare parvum ter in die Form and ambiguity; The prescription is written completely in Latin and it is clear what the prescriber intends. Official abbreviations and dose of each active ingredient: Calcii Bromid. Sod. Salicyl. Incompatibility: Insoluble calcii salicylate is formed by double decomposition. Method of compounding: If one knew the prescriber or his methods, he certainly would attempt to secure permission to replace the calcium bromide with sod.brom. In the absence of such permission, however, the two salts would be dissolved separately, in about half the water and the two solutions mixed. Ordinarily, the more dilute the solution, the lighter the precipitate and hence, the better it remains in suspension. Hot concentrated solutions, on the contrary, produce precipitates which fall quickly to the bottoms of containers and are harder to suspend on account of their dense nature. Corrected Prescription; As above. Labi,.; (Shake Well) one (1) teaspoonful three times a day. 27a Rx Tinct. Cardamom! 30 Spititus Chloroform! 30 Codeini 0.3 Pepsini 2.0 Mi see Sig, Agit.vas. 4cc q.i.d. Form and ambiguity There has been no tincture of cardamom except the compound tincture of the U.S.P. Otherwise, what the prescriber intends is clear. Codeini should be codeinae. Official abbreviation and dose of each active ingredient: Tr, Cardam. Co, 2,0 Sp. Chlorof, 2,0 Codein. 0.02 Pepsin. 0.13 Incompatibility: Pepsin is coagulated by highly alcoholic liquids. The above will run into about 10% alcohol. Coagulated pepsin is a rubbery stringy mass which cannot be incorporated into the mixture in any ether way than by adding enough water to dissolve it. Method of compounding; The prescription should not be dispensed as written. The codeine should be dissolved in the spirit of chloroform and the compound tincture of cardamom added. The pepsin should be gradually sprinkled onto the surface of 80 cc of water and stirred gently until it is dissolved. Then the two solutions are to be mixed slowly and without violent agitation. Pepsin is deteriorated by heat, agitation, or long standing in solution. It is only slowly soluble in water and there is no way to increase the rate of solution. It is one of the times a compounder must exercise patience. Needless to say the dose must be doubled if the prescription is compounded after this method. Corrected Prescription: Lable 27 Dr. Keep in a cool place. Shake -well and take 2 teaspoon- fuls four (4) times a day. For Jan . 32, 1940. Rx Tincturae Cardamom! Conpo sitae 30 Spiritus Chloroform! 30 Codeinae 0,3 Pepsin! 2 Aquae Destillatae qs 120 Mi see Sig. Agit.Yas.4cc. q.i.d. 28a Rx Quin. Sulf. 4,0 Tr. Nucis. Vom. 2,0 Sp.Amn. Arom, 8,0 Syr. Aur. 25.0 Aq. qs 180.0 Ft.Mist, Sig, Tablespoonful before meals. Form and ambiguity: This is a case where the U.S.P, abbreviation comes to one's aid. Quin.Sulf. is the official abbreviation for quinine sulfate, which might otherwise be interpretted as quinidine sulfate. Not all of the abbrevia- tions used in this prescription are the official ones, however, although there is little doubt as to what is meant, Aur, might be either gold or orange (aurum or aur antiurn), but since there is no syrup of gold, syrup of orange is intended. Official abbreviations and dose of each active ingredient Quin. Sulf. 0.33 Tr.Nuc,Von 0.17 Sp. Ammon. Arom. 0.66 Syr.Aurant. Aq. Incompatibility: The quinine is soluble in the tincture of mix vomica and water but is gradually thrown out of solution along with the oils of the aromatic spirit of ammonia by the alkalinity of the finished prescription. These substances coat the sides of the container and cannot be removed from the bottle. Method of compounding: Powder the quinine sulfate and add the tincture of mix vomica to it in the mortar, add the syrup of orange and most of the water and stir with the pestle. Add the aromatic spirit of ammonia and as soon as effervescence has ceased, add 15 cc of mucilage of acacia and stir rapidly till emulsified. Dispense the mixture with a shake lable. Corrected Prescription: Lable: 29 Dr. -JHHHHHHHHf SHAKE ML BEFORE TAKING. Tablespoonful before meals. For Jan. 32,1940 Rx Quin,Sulf. 4.0 Tr, Nuc. Vom. 2.0 Sp. Ammon. Arom, 8.0 Syr. Aurant. 25.0 Mucil.Acac. 15.0 Aq. qs 180,0 Ft.mist. Sig. Tablespoonful before meals. 29a Rx Sp, Mindereri 60 Hartshorn 6 Succi Limonis 60 Ft. Sol, Sig. Teaspoonful every hour. Form and ambiguity; The prescription is written in a mixture of old synonyms and these have been latinized. With the aid of a list of synonyms, it is easily understood. See corrected prescription below. Official abbreviations and dose of each active ingredient Liq. Ammon. Acet. 2.0 Ammon. Garb. ) These two ingredients react to form Succ.Limon. (not official) ) ammonium citrate, so that the dose cannot be calculated directly. About half of the ammonium carbonate is converted to citrate, which means the finished preparation contains roughly; Ammon. Garb. 0.2, Ammon.Git. 0,5, Ammon,Acet. 0.12 Gm. per dose. None of these is excessive. Incompatibility; As mentioned it is intended that the ammon, carb. and lemon juice react to form ammon. cit., so this can hardly be called an incompatibility. The worst feature of the prescription is that an excess of ammonium carbonate remains, more than enough to neutralize the excess of acetic acid in the sol, of ammon. acet. Ammonium acetate is unstable and rapidly decomposes in neutral and alkaline solutions. Method of compounding; Powder the ammonium carbonate and dissolve it in the lemon juice. Lastly add the solution of ammonium acetate while the mixture is still in the mortar. Not to be filtered. Corrected Prescription: Rx Liq, Ammon* Acet. 60 Ammon, Garb. 6 Succ. Limon, 60 Ft. sol. Sig. Teaspoonful every hour. Lable: 30 Shake well before using. One teaspoonful every hour. For Jan, 32,1940. 30a Rx Sodii Salicylatis Sodii Broniidi Aquae Bestiliatae qs M# ft. sol, Sig, teaspoonful three times a day. Form and ambiguity; No ambiguity: form satisfactory. Official abbreviations and dose of each active ingredient: Sod. Salicyl, Sod. Bron. i.q.Dest. Incompatibility: None Method of compounding; Dissolve the salts in the water. Corrected Prescription: As written Lable: 31 Dr Teaspoonful three (3) times a day. For Jan. 32,1940. 31a Rx Gelatin! 1.0 Glycerin! 25.0 Aquae Dest. qs 15.0 Mis co Sig. Glycerin jelly. Forn: Satisfactory. Official abbreviations and dose of each active ingredient: Gclat, Glycerin Aq, Dost. No doses, the preparation being for external use. Incompatibilities; None Method of Compounding: Add the gelatin to the water and warm 'the mixture on a water bath until completely liquefied, then add the glycerin. Mix well and allow to cool. If the jelly is dispensed in jars they should be kept tightly closed. The jelly is hygroscopic. Collapsible tubes are the ideal containers for such preparations. Correct English Prescription; Rx Gelatin 1,0 Glycerin 25.0 Distilled Water 15.0 Mix Lable- Glycerin jelly. Lablc: 32 Dr Glycerin jelly. KEEP THE JAR TIGHTLY CLOSED. For Jan. 32, 1940. 32a Rx Phenazone 50- Sod. Sal. 30- M. f t,char t.no,xv Sig. One powder three times a day. Form: Written in a mixture of Latin and English. Phenazone is an official synonym for Antipyrine U.S.P. Otherwise what the prescriber intends is clear enough. Official abbreviations and dose of each active ingredient; Antipyrin. 2.0 On. OVERDOSE Sod. Salicyl. 2.0 Gm. A large dose. Incompatibility The dose of antipyrine is excessive. A recheck on the quantities found that 5.0 Gm, of each had been dictated, and had been written as 30. Antipyrine and sodium salicylate liquefy when brought into intimate contact. Method of compounding; Powder each ingredient in a separate container and mix on paper, or measure then separately directly onto the powder papers. This pr eparation could be dispensed advantageously in solution. Each of the drugs is sufficiently soluble to permit dispensing as 60 cc. of a solution containing 3.0 Gm. of each. Correct English Prescription; Rx Antipyrine 3 0 Sodium Salicyl- ate 3 0 Mix and prepare 15 powders. Lable- One (l) powder three tines a day. Lable: 33 Dr . ■JHHHHHHHHHr# One powder three (3) tines a day. For Jan. 32,1940. 33a Gm. or cc. Rx Chloral Hyd, 20* Sod. Brom, 10* Barbital! 2* Tr. Bellad. 20- Elix. Arom. qs 120- T'T ivi • Sig. 8 cc hor. dec. Form: There is no ambiguity. Official abbreviations and doses of active ingredients Chloral. Hydr. Sod. Brom. Barbital. Tr. Bellad. Elix. Arom. 1.3 Gn. .6 Gn. .13 Gn. 1.3 cc. Incompatibility; Chloral alcoholate is precipitated as an oily liquid floating on the surface of the mixture. It is likely that there is more barbital than will dissolve in the liquid, only experiment will determine this. Method of compounding: Triturate the barbital until finely powdered and add the tincture of belladonna. Powder the chloral hydrate and sodium bromide,with about 15 Gm, of acacia and dissolve it in the aroma-tic elixir. Add the first mixture to the second with constant stirring. DO NOT USE SOLUBLE BAR- BITAL. It is sufficiently alkaline to decompose the chloral hydrate. The incompatibility cannot be avoided unless the chloral and sodium bromide are dispensed as one liquid and the other ingredients as a second. Correct Latin Prescription: Lable: 34 Dr.-XHHHHHHHHHHc SKAKE WELL BEFORE USING. Two (2) teaspoonfuls before retiring. For Jan.32,1940, Rx Chloralis Hydratis 20.Gn. Sodii Bronidi 10,Gn, Barbitali 2,Gm. Tincturae Bclladonnae 20.Gm, Elixiris Aromatici qs 120.cc. Misee. Sig. 8 cc. hora decubitus. 34a Rx Phenobarb. Sodii 75 Tr, Bellad. 10 Elix.Peps,Comp. qs 60 Mi see Sig. Teaspoonful every four hours. Form; Satisfactory, although some of the abbreviations are not the best. Official abbreviations and doses of active ingredients; Phonobarb. Sol. 0.05 Gm, Tr. Bcllad. 0.6 Elix, Pepsin. Co. Inc ompatib ili ty: Soluble phenobarbital is converted to the insoluble acid form by acids in the compound elixir of pepsin, with a corresponding loss of acid by the elixir. It is doubtful whether the phenobarbital will be precipitated due to the alcohol in the elixir. Method of Compounding; Dissolve the soluble phenobarbital in the tincture of belladonna. Determine by trial of a portion whether or not phenobarbital is pre- cipitated by the elixir in ’the proportions given. If it is add sufficient alcohol to the phenobarb!tal-belladonna solution before diluting vd-th the elixir. Correct English Prescription; Lable: 34 Dr . One (l) teaspoonful every four (4) hours. For Jan .32,1940. Rx Soluble Phenobarbital 0.75 Tincture of Belladonna 10,00 Compound Elixir of Pepsin up to 120,00 Sig. Teaspoonful every four hours 35a For John L, Green Ward 5 Jan.32,1940 Rx Arg. Prot. Mit. 1.5 N, S, S. qs. 30, M. Sig. Locally. Form: The abbreviation N, S. S, is one familiar in some hospitals. It means normal saline solution. Official abbreviations and doses of active ingredients: Arg. Prot. Mit. no dose {o% sol.) Liq,Sod.Chlor.Physio. Incompatibility: Silver chloride is very slowly precipitated and the preparation gradu- ally becomes milky brown in color. Method of Compounding; Dissolve 1,5 Gm. of mild silver protein in 15 cc, of water. Dissolve 0.13 Gm. of sodium chloride in 15 cc, of water. Mix the solutions. No suspending agent is required. Since the directions do not state to what part the application is to be made, none should be used, as the suspending agent might interfere with body fluids in some cases. Correct Latin Prescription; Rx Argenti Proteinici Mitis 1.5 Gm. Liquoris Sodii Chloridi Physiologic! qs 30.0Gn. Ilisce Sig, Locally. Lable: 36 Dr. J. J. Jay Shake Well Before Using. Use locally as directed. For John L. Green Ward 5. Jan. 32,194-0. 36a Rx Sp. Glenoin 2 Aq, Best. qs 120 Ft. Sol. Sig, Teaspoonful p.r.n. Form; Satisfactory. Sp. Glenoin is a synonym for spirit of glyceryltri- nitrate. Official abbreviations and doses of active ingredients; Sp, Glyceryl, Trinitrat, 0.06 Aq. Best. Incompatibility: Spirit of nitroglycerin will not form a clear solution ■with this amount of water. There is also likelihood of hydrolysis of the ester in aqeous solutions of the spirit. It would be better in all respects to dispense the spirit as such and measure the dose with a dropper. Method of Compounding; Determine with a smaller amount the amount of alcohol necessary to dissolve the nitroglycerin, this amount to the spirit and dissolve the solution in sufficient water to make 120 cc. Correct Latin Prescription: Rx. Spirit! Glycerylis Trinitratis 2. Aquae Destillatae qs 120, Misce fiat solutio Sig. Cochleare parvum pro ro nata. Lable: 37 Dr. -::-!hhhhhhhh:- One (1) teaspoonful as needed. For Jan.32,1940 37a Rx Liq, Acid, Arsenosi 15,0 Strychnin, Sulfat. 0.06 Ft.Sol, Sig. gtt.ii t.d. Form: Satisfactory although the abbreviations used arc not the official ones. Official abbreviations and doses of active ingredients Liq.Acid.Arsen. 0.125 (approximately, depending Strych.Sulf. 0.0005 upon the size of the drop) Therapeutic Value: Alterative and stimulant probably for a child as average adult doses are about twice the size of the ones prescribed. Such mixtures are used in nerve disorders, and digestive disorders. In c ornpa tibili ty; Strychnine arsenite is precipitated. Method of compounding: Alcohol will prevent the precipitation but mil involve increasing the total volume. The only other solution is to dispense the drugs separ- ately. In either case the prescriber should be consulted. The mixture should not be dispensed as written, because the precipitate cannot be equally diffused through a liquid being used with a dropper. Dissolve the strychnine sulfate in 15 cc. of alcohol and add the solution to 15 cc, of solution of potassium arsenite. Lable accordingly. Corrected Prescription: Lable: No. 58 Dr.-JHHHHHHHHHHHfr Four (4) drops three (3) times a day. For Jan.32,1940. Rx Liq, Acid. Arsen. 15.00 Alcohol!s 15.00 Strych.Sulf. 0.06 Ft.Sol. Sig. gtt.iv t.d. 38a Rx Sod.Sal. Ac.Sulf.Aron. Aq.l'.Pip. qs ll.rt.nist. Sig. 4 cc. alt. hor. Form; The abbreviations used are very brief, but fortunately are easily interpreted. Official abbreviation and doses of active ingredients; Sod. Salicyl. Acid.Sulfuric.Aron. Aq. Month. Pip. Therapeutic value;: The nixture is intended as an analgesic and antipyretic, ins aromatic sulfuric acid is added probably in an effort to decrease the irritation and nausea frequently associated "with the administration of salicylates. Incompatibility; Sodium Salicylate is decomposed by the ionically strong sulfuric acid liberating salicylic acid with the formation of sodium snli^ylateL. There is not enough water present to keep this amount of salicylic acio in solution. Method of Compounding: A rough calculation shows that 2/3 of the sulfuric acid is con suned in the reaction, so that the finished preparation contains enough salicylic acid to make it more irritating than the sodium salicylate i self The acid should be left out of the mixture, with the consent- of the prescribe!’, of course, If it is impossible to obtain this consent there is no alternative but to dispense the mixture as written, wiii a shake lable. Lable: NO. 39 Dr . SHAKE WELL BEFORE TAKING One (1) teaspoonful every other hour. For Jan.32,1950. Corrected Prescription; Rx Sod. Salicyl. Acid.Sulfuric.Aron. Aq,Month.Pip. qs M. ft. mist. Sig. 4 cc. alt. hor. On the assumption that the acid is used in the prescription. 39a Rx lodo 3,0 Alcoholis 9.0 Olci Terebinthinae 50,0 Ft.mist. Sig, For inhalation. Form: Satisfactory. Official abbreviations and doses of each active ingredient; lod. None for alcohol 01. Tereb. No doses. The preparation is for inhalation. Therapeutic value: The preparation is intended as an expectorant by inhalation, presumably from the surface of boiling water• Fixtures oi the sort night be used in bronchitis, laryngitis, etc. Incompatibility: Oil of turpentine is oxidized vdth considerable violence by iodine or other oxidizing agents, as in other oxidations, the violence of the reaction is controlled by the concentrations of the reagents and this prescription can be handled safely only by diluting the iodine. Method of compounding: Dissolve the iodine in the alcohol and add the solution a little at a tine to the oil of turpentine. Corrected Prescription; As written Lable; Not to be swallowed. For inhalation as directed. Rx Ac. Nit. Hyd, 8.0 Tr.Card.Co. qs 30.0 M. Sig. gtt. v a.c. Form: Not too much difficulty should be encountered with Ac. Nit. Hyd. Nothing but Acid.Nitrohydrochlor. could be meant. One is faced however, with the possibility of the diluted acid being intended. Since the dose is not excessive if diluted sufficiently, however, the strong acid should be used. The directions should include dilution. Official abbreviations and doses of active ingredients; Acid. Nitrohydrochlor, 0.05 cc. Tr. Cardan.Co. 0.25 cc. (approximately) Therapeutic value: Diluted acids are an aid to gastric digestion, and Tr, Car dam. Co. is added for the same purpose. It is difficult to see the value of it in the 3 to 4 drop dose this prescription contains. Incompatibility: The preparation will blow up in a few hours time, ihe delay in the reaction makes the preparation all the more dangerous. Method of compounding: The Compound tincture of cardamom should be entirely omitted. If the prescriber will not consent to this a refusal to compound tne prescription is in order, A safe preparation results if water is used in its place and an amber container used. Lable: 41 Dr. Five (5) drops diluted with water before meals. For Jan.32,1940. Corrected Prescription: Rx Acid.Nitrohydrochlor. 3.0 Aq, Destillatae qs 30,0 M. Sig, gtt. v diluted with water before.meals. 41a Rx .Arg. Nit. 7.5 Aq. Lavand. qs 60.0 M, ft.sol, Sig, Apply e.m.p. Form; The official abbreviation of silver nitrate is not used. As the nitrite is not commonly used in medicine, however, there is no doubt that the prescriber intends the well-known nitrate. Official abbreviations and doses of each active ingredient Arg, Nitras (Nitrat. in gen.) 12-0$ No Dose - External. Aq. Lavand, Therapeutic value: The solution is a typical caustic and is intended to remove soma obnoxious growth such as warts. In c onpatibili ty: Organic matter is oxidized by the silver nitrate with consequent reduction of the silver nitrate. Method of Compounding: Distilled "water should be used to dissolve the silver nitrate. This substitution could be defended and should require no consent of the prescriber, other things being equal. The lavender "water is added in an effort to make the preparation pleasant smelling. It has no medicinal value. Corrected Prescription: Rx Arg. Nitrat. 7,5 Aq. Best. qs 60.0 11, ft. sol. Sig. Apply e.m.p. Lablc: 42 Dr. ********* Poison 1 - FOR EXTERNAL USE ONLY. Apply to affected part as directed. For Jan,32,1940. 42a Rx Mag,. Sulf. 30. Elix. Aron, 120, M. ft. Sol. Sig: 15 cc at night. Form: Satisfactory. Official Abbreviations; Magnesium Sulfate is sparingly soluble in alcohol. The aromatic elixir being approximately 25$ alcohol would of course ppt, the magnesium -sulfate. Method of Compounding: The magnesium sulfate is desired in solution to insure correct dosage, therefore water may be used or Low-Alcoholic Elixir, which contains approximately 10$ alcohol. Table: Take one tablespoonful at night. 43a Rx Bis. Subnit. 6,0 Sodii vcl potassii iodidi 6.0 Misce et in chart, no xii div. Sig. Capiat unam ante cibnm. Form; Ciburn should bs cibo. Official abbreviations and Doses of Active Ingredients: Bisnu Subnit. Sod, lodid. Pot. lodid. 0.5 Gnu 0.5 Gnu or Therapeutic Value; The pui'pose of such a mixture is somewhat obscure. It is probably intended to relieve nausea. The iodides themselves arc ratner nausea ting however. There are many ailments in which the use of iodides is indicated. In conpatibility: If triturated strongly iodine is liberated from the iodide. Method of compounding; As iodides are somewhat deliquescent, the iodide should be first triturated id. th about 12 Gm. of starch. The bismuth subnitrate should be incorporated into this mixture on a piece of paper or by sifting. Corrected prescription: Rx Bisn. Subnit. 6.0 Sodii lodidi 6.0 Llisce et in chart. No.xii div. Lable; 44 Dr. -)hhhhhhhhhhh;- Take one powder before meals. For Jan.32, 1940, Sig, Capiat unam ante cibo. 44a Rx Benzyl Benzoatis 5,0 Aquae 60.0 Misce sec. art. Sig. Cochleare parvuin quaque quatuor hora. Form; Should be horae in directions. Should be Benzylis Benzoatis. Official Abbreviations: Benzyl Benzoate is not official. Dose 0.5 cc./teaspoonful. Aq, Therapeutic Value: The prescription is intended as a liquid preparation of benzyl benzoate intended to relieve spasm. There is no way to determine from the prescription, the location of the trouble. In compatibility: None, when the nature of benzyl benzoate is known, and the sub- scription taken into consideration. Benzyl benzoate is insoluble in water. An emulsion is intended. Method of Compounding: Place the benzyl benzoate into a perfectly dry bottle and add 5 Cm, of acacia. Mix well by agitation. Add all at once, 10 cc. of distilled water and agitate violently until a primary emulsion is formed. Dilute gradually with small additions of distilled wa.ter. Corrected Prescription: Lable; 45 Dr, Stars Shake Well Before Using;. One (1) teaspoonful every four hours. For Jan. 52, 1940. Rx Benzoatis 5.0 Acaciae 5.0 Aquae qs 6.0 Mi see sec art. Sig. Cochleare parvum quaque quatuor horae. 45a Rx Said 0,3 K16"01 Chlorobutanol aa o.ob Misce et dent, tales doses decim. Sig. A capsule every two hours. Form Satisfactory if somewhat far-fetched as regards the subscription. Official Abbreviations and Doses of Active Ingredient: Phenol (no abbreviation) .05 Gm. Chlorobut »G5 Gm, Phenyl Salicyl. *3 Incompatibility; All of the ingredients form a liquid by eutexsia. The liquid is oily and will not dissolve gelatin. Method of compounding; There .ore two possibilities; 1. Add sufficient of some absorbent powder to permit encapsulating the mass. This will make a rather large capsule. 2, Dispense the liquid as such in a capsule. If this is done a^small amount of some bland oil should be added to cut down irritation. Olive or sweet almond oil or liquid petrolatum may be used. The vegetable oils would be preferable. In all such cases a certain amount of loss oi liquid is inevitable. It is well to make up enough liquid for 12 capsules to insure adequate and even dosage. In this case, a satisfactory method would be to liquefy by trituration; 3.6 Gm. of salol, and C.6 Gm. oi salol and chlorobutanol. Then by the addition of a small amount of olive oil transfer the liquid to a small graduate and add olive oil to a conyenien multiple of 12 in tenths of a cc. Then with a graduated pipette place the liquid in capsules and seal them with mucilage oi acacia. Corrected Prescription; (Latin) La.blc; Rx Phenylis Salicylatis 0.5 Phenolis Chlorobutanolis aa 0.05 Misce et dent, tales doses decim. Sig. Capiat capsulam unan quaque duo horae. 46 Dr. Stars Take one capsule every two (2) hours, For Jan•32} 1940. 46a Rx Tinct. Ferr. Chlor. Antipyrinae Glycerini Aquae qs Ft. garg. Sig. Dilute with an equal volume of water and gargle every hour. Form; Satisfactory. Official abbreviations and Doses of Active Ingredients; Tr. Ferr. Chlor. Antipyrin. Glycerin. nq. If swallowed Incompatibility Intentional - the antipyrine colors the solution a brilliant reddish color. Glycerin also modifies the color somewhat. Method of Compounding Dissolve the antipyrine in some of the water and add the glycerin anu then the iron tincture. Add water up to 60 cc. Corrected Prescription: Lable: 47 Dr. Stars Dilute with an equal volume of water and gargle every hour. For Jan.s2, IS4O. Rx as 47a Rx Potass. Git, Potass. Acet. aa 15 Liq.Ferri et toon. Acet atis qs 120 Ft. sol. Sig. Dessertspoonful twice a day. Form; Satisfactory. Official abbreviations and doses of active ingredients: Pot. Git. 1.0 Gm. Pot. Acet. 1.0 Gm, Liq. Ferr. et Ammon,Acet. approx. 6 cc. In compa tibili ty: The solution is colored green by the same reaction that takes place in the preparation of tr. ferr. citrochlor. Method of Compounding: Dissolve the salts in the solution of iron and ammonium acetate. Corrected Prescription: As written. Lable: 48 Dr. Stars. Dessertspoonful twice a day. For Jan. 32, IS4O. 48a Rx Antipyrinae 10 Sp. Nitre 20 Liq, Pot. Cit. qs 120 Ft. sol. Sig. 4 cc. q hor. feb, dur. Form: Sp, Nitre is the only thing written in English. Official abbreviations and doses of active ingredients: Antipyrin. 0.3 On, Sp. Aeth. Nitrit, 0.6 cc. Liq.Pot,Git. approx. 3.5 cc. Incompatibility: Spirit of ethyl nitrite probably will form a colored compound vrith the antipyrine and mth the strength and concentration varying as it must in such a mixture, the color is apt to vary in depth. Method of compounding: Dissolve the antipyrine in sufficient of the solution of potassium citrate to make 100 cc and add the spirit. Corrected prescription: Rx Antipyrinae 10 Spiriti Aethylis Nitritis 20 Liquoris Potassii Citratis qs 120 Ft. sol. Sig, 4 cc. q hor. fob. dur. Lable: 49 Dr, Stars One teaspoonful every hour as long as the fever lasts For Jan. 32, 1940 49a Rx lodoformi 2,0 Collodii Flexib. 30.0 M. Sig. Apply with a brush. Form; Satisfactory. Official abbreviations and doses of active ingredients: lodof. 6% approx. Collod. Flex. In c ompa tib ili ty: None Method of compounding; Dissolve the iodoform in the form of a fine powder in the flexible collodion. Corrected Prescription; As written Lable: 50 Dr. Stars For External Use Only Apply with a brush. For Jan. 32, 1940, 50a I-? 'V' IWL Hydrarc# Chlor. hit. Sod. Bafom. I,:, ft. Chart XV Sig: 1 in Aq at bedtime. Form: Satisfactory, Official Abbreviations: Hydr ar g. Chi or i cl, I£L t. Incompatibility: The bromide mil oxidize the calomel to the bichloride. Method of Compounding: This prescription should not be compounded or dispensed, ■JVhen dispensing Calomel one should always avoid contact with the halides or any agent which nay oxidize and form the bichloride. Lable: One powder in water at bedtime. 51a For... ,L. .C. .Brown Rx On. or cc Soap Liniment 45 Methyl Salicylate !0- j Mix Sig. Rub well into back at night. No. Surgeon U.S.A. Form: Satisfactory; the prescription is written in English. Official abbreviations and doses of active ingredients: Lin. Camph. et Sapon. Methyl. Salicyl. no doses Therapeutic value: An analgesic for external application as stated in the directions. In c ompatibility: The methyl salicylate is insoluble in the soap liniment, but the soap emulsifies the oil temporarily, long enough for the efficient application of the liniment. Method of Compounding: Mix the ingredients as written. No gum should be added. The use of a small amount of Lin. of Soft Soap while not objectionable is net essen- tial. Corrected Prescription As written. Lable; 52 Dr*. Stars. FOR EXTERNAL USE ONLY Shake well and rub into back at night. For L.C.Brown, 1940. 52a Rx Potassi-Acetatis 15 Tr. Belladonnas 10 Elix. Aromat. qs ad GO Misce fiat solve. Sig, Teaspoonful three times a day before meals. Form: Potassi-Acetatis is a queer form but clearly intelligible. The form otherwise is regular. The verb solve should be a noun solubio. Official abbreviations and doses of active ingredients; Pot. Acet. 1.0 Gn. Tr. Bellad. 0.6 cc. Elix. Arom. Therapeutic value; The mixture is an alkaline diuretic. Potassium acetate is oxidized in the system to potassium carbonate and is so excreted in the urine. Bella- donna relaxes peripheral vessels and thus indirectly increases the -i-low of urine. Incompatibility; None. Method of Compounding; Fix the ingredients and shake until the potassium acetate is dissolved. Corrected Prescription; Rx Potassii Acetatis 15 Gin, Tr. Belladonnas 10 cc. Elix. Arom. qs 60 cc. Misce et fiat solutio. Sig. Teaspoonful three times a day before meals. Lable: 53 Dr. Stars. Teaspoonful three (o) times a day, before meals. For Feb. 30,1940,1940 53a Rx Pot. Brom. 10 Chloral. Hyd. 10 Aq. Chloroforni qs 30 lift Sol. Gig. 2 cc in hot aq. s. h. Form a.h. should be h.s.; otherwise the prescription is correct. Official abbreviations and doses of active ingredients; Pot. Brom. 1. Cm. Chloral.Hydrat. 0.25 Gn. Aq. Chlorof. Therapeutic Value: A sedative mixture• Both chloral, hydrate and potassium bromide are sedatives or hypnotics. The chloroform water is of little value except to disguise the taste of the other ingredients. In c ompatibility; There will probably be some salting out of the chloroform, therefore the quantities of the salts should be reduced to 8 Gm. for the Pot. Brom. and 5 Gn. for the Chloral. Hydrate. Method of Compounding; Dissolve the salts in the chloroform water. Filter if necessary. Corrected Prescription: Rx Potassii Eronidi 8 Gnu Chloralis Hydratis 2 Gm. Aquae Chloroforni qs 30 cc. Mi see Sig. 2 cc. in hot aq. h. s. Table; One teaspoonful in hot water at bedtime. 54a Rx Hyd. lod. Rub, Elix, Aron, Aq. Dost. I'isce. Sig, 2 cc. in aq. t.i.d.a.c. No. 55 Form: Hyd. lod. Rub. is perhaps, ambiguous at first glance. It could, however, be nothing but an abbreviation for Hydrargyri lodidi Rubri or red iodide of mercury (red mercuric iodide.) Official abbreviations and doses of active ingredients Hydrarg, lodid. Rub. Elix. Aron. Aq, Dest. Incompatibility: Red mercuric iodide is insoluble in a mixture of alcohol and water of this nature. Method of compounding Triturate the red mercuric iodide with an equal amount of potassium iodide and add the water. Stir until dissolved. Add the aromatic elix- ir and transfer to a prescription bottle. Add sufficient distilled water to make 60cc. Corrected Prescription: Rx Hydrargyri lodidi Rubri Elixiris Aromatici Aquae Destillatae Ilisce Sig, 2 cc. in aq. t.i.d.,a.c Lable: 55 Dr. Stars. A half (J) teaspoonful in water three (5) tines a day, before neals. Per Jan. 30,1940. 55a Rx On. or cc, Strychninae Sulfatis 5 Alcoholis 10 Aq. Best. qs 50 Fiat Sol. Sig. 1% solution of strychnine sulfate. No. 56 Form; Satisfactory. Official abbreviations and doses of active ingredients. Strych. Sulf, Alcohclis. Aq. Best. No doses of the preparation given -a 1% solution. Incompatibility: None, Method of compounding; Bissolve the strychnine sulfate in the nixed solvents. Corrected Prescription; As written Lable; 56 Dr. Stars 1% Solution cf Strychnine Sulfate. For F0b.30, 1940. 56a Rx Gn. or cc. Kal. Chlor. v ’7' 5^ Acid. Tannici £ 0 Acid. Borici £ 0 Glycerin! 10 0 Aquae Destillatae ad I£o 0 n. Sic* Dilute to 15 cc. with water and use as a gargle. No. 57 Form: The directions are apparently incomplete, A call to the physician was made and it was learned the directions meant were "Dilute 4 cc. to 15 cc. with water etc.". Official abbreviation and doses of active ingredients: Pot. Chieras, (chlorat. here) 0.25 Gn. Acid. Tan. ■ 0.06 Gm. i'xcid. Boric. 0.06 Gn. Glycerin. Aq. Best. If swallowed, which is unlikely. Therapeutic Value An astringent and antiseptic gargle. Incompatibility: Potassium Chlorate is incompatible with the organic matter present. If it is separately dissolved first, however, the reaction proceeds very slowly. In sufficient time none of the ingredients would escape change except the water. Method of Compounding; Rub the two acids with the glycerin in a mortar, .mid 100 cc. of satur- ated solution of potassium chlorate and when solution is conpletea, timu- fer to a prescription bottle. Add water if necessary to make 120 cc. De- fer e the transfer. Corrected Prescription; As witten, except; Sig. Dilute 4 cc. to 15 cc. with water and use as a gargle. Lable; 57 Dr. Stars. Dilute a teaspoonful with water to make a tablespoonful and gar- gle as directed. For Feb. 30,154( 57a Rx Gm. or cc. 7 5 Acid. Sod. Garb. 15 Tr. Nucis Vomicae 7 5 Elix. Pepsini Comp, qs 120 A. Sip, 4 cc. 1 h. a. c. No. 58 Form: The prescription is written in a Fixture of chemical names in English and of Latin names of preparations. Official abbreviations and closes of active ingredients: Bisn. Subnit. 0,25 Gn. Sod. Bicarb. 0.5 Gm. Tr, Luc. Von. 0,25 cc. Elix. Pepsin. Co. Therapeutic Value: The mixture is probably intended as a stimulant to digestion, with perhaps, the bismuth salt probably added to combat some nausea. In c onpatib ility: Both tincture of Kux Vomica and Compound Elixir of Pepsin contain acids which are necessary to their stability and therapeutic activity. The acids are of course, neutralized by the bicarbonate, and the pepsin rendered inactive in the alkaline mixture. The strychnine liberated from the sulfate will likely remain in solution as the preparation contains roughly ZG% alcohol; but other ingredients of the tincture will precipitate and make an unsightly mixture, which gets worse on standing. Method of compounding; Triturate the subnitrate and bicarbonate with 0,5 Gm. of tragacanth till thoroughly powdered and nixed, Fix the tincture with 100 cc, of the elixir and gradually add it to the powdered mixture in the mortar. The sodium bicarbonate which causes most of the trouble cannot be elim- inated without the prescriber’s consent. The basic bismuth salt will act in a similar manner but more slowly in any case. Corrected Prescription; Rx Bismuthi Subnitratis 7,5 Cm. Sodii Bicarbonatis 15,0 Gn. Tincturae Kucis Vomicae 7,5 Gm. Elixiris Pepsini Compositi 120.0 cc Labia: 58 Dr. Stars. SHAKE THE BOTTLE. One (l) teaspoonful one fl) hour before eating. For Feb,so, 1940. Rx Gm, or cc, Hydrargyri Bichloridi 2 Liq, Calcii Hydroxldi 30 Mucilagin, Acacia 30 Aquae ad 120 nr c ' l i • O • J.L • Sig. Dab on skin. No. 59 Fora: Satisfactory. Official abbreviations and doses of active ingredients; Kydrarg. Bichior, Li q, Calc. Hydrox. Llucil. Acac. Aci. no dose. Therapeutic Value; Doubtful. The lotion is intended as an antiseptic wash. In conpatibili ty: Mercuric oxide is precipitated in an aqueous mixture such as this. The mucilage here, however, prevents complete reaction here and the result is merely an unsightly precipitate of indiscriminate color. Method of Compounding; It is believed that the prescriber wanted a lotion containing the mercuric oxide, similar to the yellow lotion of the N.F. The bichloride should be dissolved in GO cc, of water an 1 this solution poured into the lime water. The mucilage should be added lastly. If the mucilage has not already been prepared, it should be made in a mortar and the mixed other ingredients added to it. Corrected Prescription: As written. Lable; 59 Dr. Stars. FOR EXTERNAL USE ONLY. Shake well and dab on skin as directed. For Feb.SO,'4o 59a Rx Gm. or cc. Sodium Salicylatis > 3 Aq, Menth. Pip. ad 4 , H.T.D.XV Teaspoonful q.i.d. No. 60 Form Unusual but satisfactory. Here the prescriber has written what he wants each dose to contain and then pr escribed a definite number of such doses in the same manner he would have written for pills or capsules. Official abbreviations and doses of active ingredients; Sod. Salicyl. Aq, Month, Pip. 0.3 Gm. Therapeutic Value; Sodium, salicylate has analgesic and antipyretic properties. It is frequently used in the treatment of neuritis and arthritis. Incompatibility None. Method of compounding Dissolve 4.5 Gm. of sodium salicylate in sufficient peppermint water to make 60 cc. Filter if desirable. Corrected Prescription: As witter, or Rx Sod. Salicyl. 4.5 Aq, Ilenth# Pip. qs SO.O T T i L« Sip. Teaspoonful q.i.d. Lable: 30 Dr. Stars. One (l) teaspoonful four (4) times a day. For Feb. 30, 1940. 60a Rx On, or cc. Olei Ricini 251 Salolis 1 Acaciae qs Aq. Cinnan, qs 60 Ft, Enulsio Siq. Take half a bottle at once. Repeat tomorrow. No, 61 Form: The form is satisfactory and clearly intelligible. It would bo better to write the actual quantity of castor oil, however, as a general practice; if the percent sign were to be misread or effaced, an error is possible. Official abbreviations and. doses of active ingredients 01. Ricin. 7.5 cc. Phenyl. Sali cyl. 0,5 Cxn. Acac. Aq, Cinnan. Therapeutic Value: .1 laxative and intestinal antiseptic. Incompatibilities: The salol is insoluble in water, and if carelessly mixed, separates readily from the mixture. Ilethod of compounding: Dissolve the salol in the castor oil until a clear solution is the result. Add the acacia all at once (at least 2 Gn.) and nix uniformly with the oil—salol solution. Add twice the amount oi water as acacia, all at once and stir briskly until an emulsion is the result. Dilute to 60 cc. by the gradual addition of cinnamon wo.ter. Corrected Prescription: Rx Olei Ricini 15.0 Phenyl. Sali cyl. 1.0 Acaciae P.O Aq. Ginnam. qs 60.0 Ft. Emulsio. Lable: 61 Dr. Stars. SHAKE WELL BEFORE USING. Take half the bottle at once. Repeat tomorrow as directed. F0r.... Fob. 30, 1940. 61a Rx Gn» or cc# Petrolat. Liq. I^o Fldext. Case. Saq. Aron. 30 Acaciae qs _ , o /tn Aq. nest. qs 11. S. A. Siq, Tablespoonful before oreakfast. No. 62 Form: Satisfactory. Official abbreviations and "loses of active inpredion os: Petrolat. Liq. ‘ cc* Fldext, Case. Saar. .-iron. -■-•3 0c• ixCclC • Aq. Dest. Therapcutic 7alue: A laxative. Incompatibility: None except that the preparation must be properly nixed. Method of compounding: Add to the liquid petrolatum, 50 Gn. of dry powdered acacia and mix it thoroughly throughout the oil. Add, all at once, 6*oc. water end rdx briskly until an emulsion is fornea. -uu xn small i-orti . , after each addition, the fluidextract. Transfer to a pre- viously graduated bottle, and by means of the remaining few cc. of water, brinq the preparation up to quantity. Corrected Prescription: Lablc: 09 Dr. Stars. Shake -Yc-.il Before Using. One (l) tablcspoonful before breakfast. por Feb. 30, 1940. 62a puX Gm. or cc. Ext. Belladonna© 01. Month. Pip. Map. Ox.Pond. Ft, chart, i. D.T.D. no.x Sip. One in aq. 15 min. ac. No. 63 Form: Satisfactory, except that, perhaps, "ac" should be a.c. Official abbreviations and doses of active ingredients: Ext. Bellad, 01. Menth. Pip. Hag. Oxid. Pond. Therapeutic Value: An antacid powder of a type commonly used in cases of gastric ulcer. The belladonna is added to depress secretion of gastric juice, keeping down the acid content of the stomach. Incompatibility; None. Method of compounding; Carefully dilute the extract with the oxide by trituration, the oil of peppermint to a portion of the oxide and gradually dilute this into the extract by trituration also. Heigh out the powders onto papers and fold neatly. Corrected Prescription; (shoving total quantities) Lable: 65 Dr. Stars. Shake Well Before Usinft. One powder in water, fifteen minutes before each meal. For 2-30-40 Rx Ext. Bellad. 01. Menth. Pip. Mag. Oxid. Pond. To be divided into 10 papers. 63a Px Gin. or cc. Creosote 2 01. Olive qs Div. in caps. no. x Sir;, One three tines a day. No. 64 Form: Intelligible but could be improved by writing "Olive Oil" completely in English. abbreviations and Joses of active ingredients: Creosot. 0,2 cc, 01. Oliv. Therapeutic Value Antiseptic. Creosote is eliminated principally by the is used for infections in the lungs, in an attempt to secure the action of the creosote at the point of infection. Incompatibility: None, Method of Compounding: The amount of olive oil used depends upon the size of capsule used. Enough should be used to dilute the creosote to 3 or 4 times its volume. The creosote may be diluted into the oil or added from a pipette or a calibrated dropper directly into the capsules after -which olive oil may be added. The inner half of the capsules should pot be completely filled with the mixture. A little space avoids spilling over the sides with the result that sealing is impossible, and it also allows more room for air, which if too tightly compressed in the capsule, causes bubbles and misshapen capsules. It is a good plan to make up several extra capsules and test for leaking ones before dispensing. Corrected Prescription; Rx Creosote 2,0 Olive Oil qs Div- in caps, no.x Lable: 64 Dr. Stars. One (l) capsule three (3) times a day. For 2-30-40. 64a Rx Gn, or cc. Caffeinae Citratis 1 Strych. Sulfatis 001 Sacch. Lact. qs LI. Ft. tal. caps, v Sig. One after breakfast and lunch. No. 65 Form: "Caffeinae Citratis" should properly be "Citratae" othen-vise it is satisfactory. Sacch, Lact. is an abbreviation for Saccharin Lactis, an old official title for lactose. Official abbreviations and doses of active ingredients Caff. Cit. 0.1 Gm. Strych. Sulf. 0.001 On. Lactos. Incompatibility: None. Therapeutic Value: Both caffeine and strychnine salts are stimulants. They are also synergists to each other when combined. There is not enough of each pre- sent here to be dangerous. Nevertheless, it is likely the mixture will prove more stimulating than the less than average doses would indi- cate . Method of compounding; The strychnine should, be carefully diluted into the caffeine and if possible a tracer should, be added to it before the caffeine is added. The mixed caffeine and strychnine are then to be gradually and care- fully diluted with the milk sugar (199 mgm.)and the powder equally divided into five $2 capsules. These are to be weighed to detect any error either in calculation or weighing. If a trituration ol strychnine is at hand it should be used in such a preparation. Corrected Prescription: Rx Caffeinae Citratae Strych. Sulf. Lactosi. ll.ft. tal caps, v Lable: 0.100 Gn. 65 Dr. Stars. 0.001 Gn. 0.199 Gn. One capsule after breakfast and one after lunch. For Feb. 5 0,1940. 65a Rx. Gm. or cc. Acid Tan. 2 Glycerini 25 Gelatini Glycerinati qs Ft. Suppos. Rect. Dent.vi Sig. Insert one at night. No. 66 Form: Satisfactory: Official abbreviation and doses of active ingredients; Acid. Tan. 0.2 Gm. Glycerin. Gelat. Glycerin. Therapeutic Value An astringent suppository intended for use to relieve hemorrhoids. In c onpa tibility: Gelatin is precipitated by Tannic Acid. The rate oi reaction increases as more water is present in the preparation, mven if no water is used in the preparation of the glycerin jelly, enough is gradually absorbed to cause the reaction. liethod of compounding; Dissolve the Tannic Acid in the Glycerin, /ilhile it is dissolving, cool the suppository mold and if necessary calibrate it xor the glycerin Jelly you are poing to use. Have the gelatin liquid, but not sensiolg warn, '-jet all ready before nixing the tannic-in-glycerin-solution and the molten jelly. DO NOT OPT Till HOLD SO COLT) THAT IT V[lLb_.gdg-±II.L- Pour the suppositories as rapidly as accuracy permits and as scon as firm, remove them from the mold, and place then in a well s oopperem bottle i.hich io not much larger than the volume needed ior the suppositories. -*■ '-••■-. Suing powder may be used to advantage• Bear in nine, tnroughout the prepare, uion that water will cause a precipitation. If cnougn tannin were usea the suppositories would form a leathery mass which would not molt at body temperature. In this case it would be necessary to change the base to theobroma oil. Corrected Prescription; Lable: 66 Dr. Stars Keep tirhtly closed and in a cool, dry place. Insert one (l) at night. For Feb.3o, 1940. Add amount of glycerinated gelatin and number of mold, if more than one is being used. 66a Rx Liq, Potass, Ars. Syr, Ferri lodicl. 11. Sig, gtt.x t.i.cl.a.c. No', 67 Form: The abbreviation for liq. pot. arsenit. is incorrect. There is little danger in this case because potassium arsenate is not a common chemical, while solution of potassium arsenate is a commonly used galenical. The apothecaries abbreviation gtt. is probably incorrect also, but practice has sanctioned its use. Official abbreviations and doses of active ingredients Liq, Pot. Arsen. Syr. Ferr, lod. The drop-size in this preparation will be large due to the thick nature of the liquid and actual doses delivered from a dropper nay be larger than those given above. Therapeutic Value: Alterative and hematinic. Arsenic and iron "tonics’1 are commonly used, in all sorts of debilitated conditions. Incompatibilities: Both ferrous arsenite and ferrous carbonate arc precipitated in alkaline solutions. Drop preparations containing insoluble potent ingredients are very dangerous and should never be dispensed if it is possible to avoid doing so. Method of compounding: The substitution of solution of arsenous acid which is a similar preparation in strength and dose, will eliminate the trouble. Ferrous arsenite is soluble in acid solution. The consent of the prescriber is necessary to such a substitution and should be obtained. If the sub- stitution is allowed the two solutions are simply mixed by agitation. Corrected Prescription Lable: 67 Dr. Stars. Ten (10) drops three (3) times daily, before meals, as directed. For .2—30—40 Rx Liq. Acid. Arsen. Syr. Ferr. lod. 11. Sig, Ten drops t.i.d., a.c. 67a Rx Gn. or cc. Strych. Sulf. 016 Potass. lodid. 5 Aq. Cinnam. qs 60 Solve Sig. 4 cc. p.c. Ho. 68 Form: Satisfactory. Official abbreviations and doses of active ingredients: Strych. Sulf. 0.001 Gn, Pot, lodid. 0.300 Gn. Aq. Cinnam. Therapeutic Value Alterative and stimulant, night be given in several ailments. It is evidently not desired to stimulate appetite so the medicine is given after meals. Incompatibilities; lodides precipitate most of the less soluble alkaloids in aqueous solutions. Method of compounding: Dissolve the strychnine sulfate in a mixture of SO cc, of alconol and 35 cc. of water/’ Slowly and with constant agitation add 5 cc. of saturated solution of potassium iood.de X.i1. Corrected Prescription Lable: 68 Or. Stars. One (1) teaspoonful after meals. For 2-50-40 Rx Strych. Sulf. 0,016 Gn, Alcoholis 20. cc. Dist. Water 35. cc. Liq.Pot.lodid. 5. cc. Solve. 68a Rx Gm. or cc. Sulfur Peruvian Balsam aa 3 Petrolat. 9 Ft. Una. Sig, Apply, No. 69 Form; Satisfactory9 except the prescribe!’ does not specify the form of sulfur, Official abbreviations and doses of active ingredients: Sulfur. Sublim Balsam. Peruv. Petrolat. Therapeutic Value: A dermatologic paste or ointment for some itching skin ailment. Incompatibility: A grainy precipitate forms, rendering the preparation both useless and unsightly. Method of compounding: Incorporate finely powdered sulfur into 5 Gm. of petrolatum. Mix the Peruvian balsam with 4 cc. of castor oil and gradually work the sulfur paste into the balsam mixture on a pill tile. Corrected Prescription: Lable: 69 Dr. Stars. Apply as directed. For 3—30—40. Rx Sulfur 3 Gm. Petrolat. 5 Gm. Peruvian Balsam 3 Gm, Castor Oil 4 cc. Ft. Una. 69a Rx Gm. or cc. Cocainae Hydrochlor, 1 Petrolat, 5 Ft. Ung. Sig. Apply to eyelid p.r.n. Mo. 70 Form Satisfactory. Official abbreviations and doses of active ingredients; Co c a in. I lydro chior. Petrolat. Therapeutic Value: Local anesthetic. Incompatibility; Ordinarily none; but in eye preparations, particles however small, should be avoided. The cocaine hydrochloride is insoluble in petrolatum. Method of Compounding; If cocaine alkaloid is at hand, substitute that. If cocaine hydrochloride must be used, dissolve the 0.1 Gn, in a drop or two of water, incorporate the solution in 0,5 Gra. of hydrous wool fat and add the petrolatum, taking care throughout the process to exclude dust or other foreign matter. Corrected Prescription; Rx Cocainas 0,1 Cm. Petrolat, 5.0 Gm, Ft. Ung. Lable: 70 Lt. Stars. Apply to eyelid as needed. For 2—30—40. 70a Rx Said Soda Bicarbonate aa Mist. Rhei Comp. qs Ft. Mist. Sip. Teaspoonful every three hours. No. 71 Form: The prescription is written in a mixture ol Latin and Lnglish. The use of soda instead of sodium is essentially wrong. Official abbreviations and doses of active ingredients: Phenyl. Sailcyl. Sod, Bicarb. Mist. Rhei Comp. Therapeutic Value: Antacid, intestinal antiseptic, and laxative. Might be used in the treatment of a number of complaints. Incompatibility; Phenyl salicylate is insoluble in aqueous vehicles. In this mixture it forms" a flaky light insoluble portion which is particularly hard to keep evenly distributed throughout the mixture even long enough to pour out a dose. The sodium bicarbonate is also present in too large a quantity to dissolve. Method of compounding: Finely powder the phenyl salicylate by trituration and incorporate the sodium bicarbonate and 10 Gnu of acacia with it in the mortar. Add about 20 cc. of compound mixture of rhubarb and triturate to a smooth mixture. Add the remaining compound mixture of rhubarb, bring the mixture to quantity and bottle. Corrected Prescription: Lable: itx Salol Sodium Bicarbonate aa Compound Mixture of Rhubarb qs Make a mixture. 71 Dr. Stars. Shake Well Before Using One (l) teaspoonful every three (3) hours. For March 32, 1940. 71a Rx Gm. or cc. Chloral. Ilydrat. Camphorae aa 10 M« Sig, Apply to gums. No. 72 Form: Satisfactory. Official abbreviations and doses of active ingredients: Chloral. Hydr. Camph. no doses. Therapeutic Value: Local anesthetic for application to guns. Incompatibility; None. The eutectic mixture formed is desired by the prescriber. Method of Compounding: Place the finely powdered ingredients in a wide mouth bottle and warm slightly. If time is not a factor. The ingredients need not be powdered. Corrected Prescription; As written. Lable: 72 Dr. Stars. Dc Not Swallow Apply to the gums as directed. For 3—32—40, 72a Gm. or cc. Caffein Citr. Camph. aa 75 Aspirin 1 0 Salol 3 M. ft. caps. no. xii Sip. One (l) capsule every 4 hours. No. 75 Form: Satisfactory. The use of synonyms, while not the most desirable practice, is not incorrect if the synonyms are well known and not ambiguous. Official Abbreviations and Doses of Active Ingredients: Caffein. Cit. 0,06 Gm. Camph. O.Ca; • un. Acid.Acetylsal. 0 • 3 Gm. Phenyl Salicyl. 0.25 Gm, Therapeutic Value: Antipyretic and analgesic. Probably for use in treatment of a cold. Incompatibility Camphor and salol liquefy wnen intimately mixed. Method of Compounding 1, Powder and mix by trituration, the caffeine citrate, aspirin, and salol, and remove from the mortar. Powder the camphor^by the use of small amount of alcohol and add to it, 5 Gm. of magnesium carbonate. Div- ide the powder and place into 24 #0 capsules. Lable "Two capsules every 4 hours." . . _ . .■] 2, Powder and mix by trituration the caffein, aspirin and salol; divine and pack tightly into the longer end of 12 fto capsu3.es; and fill the half'1 of the capsules with lactose. Powder the camphor by the use of a few drops of alcohol and divide and place it into the capsules whose other end contains the previously mixed other ingredients. Place the caps containing the camphor on the filled capsules. This is the better solution of the problem. Corrected Prescription: Lable: Rx Caffein. Cit. Camph. aa 7 5 Acid. Acetylsal. 1 5 Phenyl Salicyl. 5 Mag. Garb. 0 M. ft. caps. no. xxiv Si.:, 2 capsules every 4 hours. 73 Dr. Stars 1. Two (2) capsules every four (4) hours. 2. One (1) capsule every four (4) hours. (Corrected prescription is shorn dor method of compounding 1 onl^.) 73a Rx Gm. or cc, Camphorae 2 Phenylis Salicylatis 3 Fae Caps, xii Sig. One t.i.d.a.c. No. 74 Form; Satisfactory. Official abbreviation and doses of active ingredients: Camph. 0.015 Gm. Phenyl. Salicyl. 0.25 Gm. Therapeutic Value. Intestinal antiseptic. Incompatibility: A eutectic mixture is formed by camphor and salol. Method of compounding: To the salol, powder by trituration, add 1,6 Gm. of magnesium carbonate and mix well. Remove the powder from the mortar. Powder the camphor and incorporate it into the first mixture without trituration. Divide the powder and place it into 12 #1 capsules. Corrected Prescription; Rx Camph. 2 Phenyl. Salicyl. 3 Mag, Garb. 1 6 M. fae caps xii Lable: 74 Dr. Stars One (l) capsule before meals, three (5) times a day. For 3-32-40 74a Rx Gm. or cc. Phenyl. Salicyl. 3 Acetophenet, Quinin. Hydrochlor. aa 1 3 Camphor 5 Calomel 06 M. ft. cap, no. xx Sig. 1 q 3 h. No, 75 Form; Satisfactory. Official abbreviations and doses of active ingredients; Phenyl, Salicyl. 0.15 Gm, Acetophen. 0.065 Gm, Quin. Hydrochlor. 0.065 Gm. Camph, 0.025 Gm. Hydrarg. Chlorid, Mit. 0,003 Gm. Therapeutic Value; The tt eparation is evidently for cold or grippe or influenza, al- though it might be for any of several conditions. It is not a generally accepted practice to administer calomel in this manner. Incompatibility Camphor and salol form a eutectic mixture. Method of compounding Mix by trituration, the salol, calomel, quinine, and acetophenetidin, and remove the mixed powder from the mortar. Powder the camphor and add to it 2.44 Gm. of magnesium carbonate. Mix thoroughly, add the previously mixed powder, and mix without trituration. Divide die powder into 20 $1 capsules each containing 0,43 Gm, Corrected Prescription; Rx Phenyl. Salicyl. 3 Acetophen Quin. Hydrochlor. aa 13 Camph. 5 Hydrarg. Chlorid, Mit. 06 Mag. Garb. 2 44 M. ft.cap.no, xx #1 cap. Lable: 75 Dr. Stars. One (l) capsule every three (5) hours. For March 32, 1940. 75a px Gm. or cc, Salol 8 Aspirin Antipyrine aa 4 Strych. Sulf. 815 Div. in caps, xxiv no. Sig. 1 every 4 hours. No. 76 Form; Satisfactory. Official abbreviations and doses of active ingredients: Phenyl. Salicyl. 0.333 Gm, Acid. Acetylsal, 0.166 Gm. Antipyrin. 0.166 Gm, Strych. Sulf. 0.0006 Gm. Therapeutic Value; Analgesic, antipyretic and intestinal antiseptic. There is so little strychnine in the preparation that it can have only a slight stomachic action. Incompatibility Aspirin and antipyrine interact with the liberation of water and a pasty powder results which if encapsulated soxtens the capsules. Method of Compounding: 1. Powder and mix by trituration the salol, aspirin and strychnine. Place the mixed ingredients in the inner halves of 24 #OO capsules; pack tightly and add a little lactose to the capsule then place in it 0.166 Gm. of powdered antipyrine. 2. Powder by trituration and mix the salol, aspirin, and strychnine sulfate; and remove the powder from the mortar. Mix the antipyrine with 4.335 Gm. of magnesium carbonate and incorporate the first ture with the second with only light trituration; divide the powder into 24 #OOO capsules each weighing 0.85 Gm. Corrected Prescription: Lable: Dr. Stars Rx Phenyl Salicyl. 8 Acid. Acetylsal. 4 Antipyrin. 4 Strych. Sulf. 848 Lactose qs Div. in caps, xxiv no. #OO caps (Corrected prescription for method of compounding No. 1 only). 76 One capsule every four (4) hours. For March 32, 1940. 76a Rx Gm. or cc. Aspirin Amidopyrine aa 5 Caffein. Git. 1 Div. Cap. no. xv Sig. One t.i.d. No. 77 Form; "Div. cap. no. xvM means divide 15 capsules, which does not make sense. It is, ho?rever, easy to guess what the prescriber means, Amido- pyrinc was the official title for aminopyrine in a former revision of the pharmacopeia. Official abbreviations and doses of active ingredients Acid. Acetylsal, .333 Gm. Aninopyrin. .333 Gm, Caff. Git. .066 Gm. Therapeutic Value Analgesic and antipyretic. Incompatibility; Aminopyrine and aspirin interact with the liberation of water, resulting in the formation of a pasty mass, which if encapsulated results in softened and messy capsules. Method of compounding: Pulverize and mix by trituration the caffeine citrate, the aspirin, and 1 Gm, of magnesium carbonate; remove the powder from the mortar. Finely powder the aminopyrine and mix it thoroughly with the first nixed powder without trituration. Divide the powder into 15 jfOOO capsules each containing 0.8 Gm. Corrected Prescription: Rx Acid.Acetylsal. 5 Aminopyrin. 5 Caffein. Git. 1 Mag. Garb. 1 Div. in cap, no. xv Sig. One t.i.d. Lable: 77 Dr. Stars. One (l) capsul three (3) times a day. For 3-32-40 77a Rx Gm. or cc. Aspirin Methenamine aa 5 M. Ft. Caps. XV Sig. One before each meal. No. 73 Form: Satisfactory. Official abbreviations and doses of active ingredients Acid, Acetylsal. 0.355 Gm, Methcnam. 0.333 Gm, Therapeutic Value: Urinary antiseptic, antipyretic, and analgesic. Inc ompat ibili ty; Methenamine and acetylsalicylic acid liquefy when triturated together. It is not -well to administer methenamine in capsules, if the capsules are to be kept more than a few days, as it slov/ly liberates formaldehyde which renders the capsules insoluole. Method of compounding: 1. If the prescriber will consent it is by far the best solution to dispense tablets in separate containers, directing the patient to take one of each. 2. Probably the second best solution is to make up capsules of methen- amine each containing 0.33 Gm. (#2 capsule). Then place 0.35 Gm. of acetylsalicylic acid and the methenamine into a larger capsule (//000), working the aspirin around the sides by rolling and shaking the capsule after it is closed. 3. Place 0.33 Gm. of methanamine (finely powdered) into the lower half of a #OO capsule, pack tightly, add a layer of lactose, and fill the capsule by adding 0,33 Gm. of aspirin. Make 15 such capsules. The second and third methods have the advantage of not requiring any consent of the prescriber. Corrected Prescription; Method 2. Rx Acid. Acetylsal. 5 Methenamine 5 M, Ft. Cap. XV Sig. One before each meal, (methenamine in #2 capsule inside #OOO capsule with aspirin). Lable: Method 2 78 Lt, Stars. One (l) capsule before each meal. For Mar. 32, IS4O. 78a Rx Crude Coal Tar Zinc Oxide Starch aa Petrolatum Ft. Past. Sig. Apply without friction. No. 79 Form; Satisfactory. Official abbreviation and doses of active ingredients: Pix. Carbon. Zinc, Oxid. Amylum Petrolat. Therapeutic Value: Antiseptic and protective paste used in dermatology. Inc ompatib ility: The crude coal tar gradually separates, leaving globules of darker colored oily material throughout the paste. Method of Compounding; (if the paste is to be used up within a few days, it would remain uniform without any admixture). To the crude coal tar add 1 cc. of castor oil mix and add the pet- rolatum. Have the powders finely divided and free from lumps. Incorp- orate the two powders into the tar—petrolatum mixture, working the mass until it is uniform. Corrected Prescription: Rx Crude Coal Tar Castor Oil aa Zinc Oxide Starch aa Petrolatum Ft, Past. Lable: 79 Dr. Stars. Apply without rubbing. For 5-32-40 79a Rx Gm. or cc. Ephedrinae Sulf. Potass. lodid. 4 Caffein. Cit. 8 Arseni Triox. 015 Aq. Best. 60 M. ft. sol. Sig. Teaspoonful as directed. No. 80 Form: Satisfactory. Official abbreviations and doses of active ingredients: Ephedrin. Sulf. 0.027 Gm. Pot. lodid. 0.027 Gm. Caff. Cit. 0.05 Gm. Arsen. Trioxid. 0.001 Gin. Aq, Best. Therapeutic Value: Stimulant and alterative, probably for use in the treatment of bronchial asthma. Incompatibility; The preparation Trill probably tern dark after standing for some time. lodine is liberated from iodides in acid solution. This preparation contains arsenous and citric acids. II free iodine is liberated it precipitates the ephedrine. Method of Compounding; Determine from the patient, what the "as directed" means in the directions. If it is found that the preparation will be used up vri.Lh.in a few days, compound it as written. If the preparation is to be taken only infrequently, and is given to the patient to be kept and taken when needed, use the following method of compounding. Replace the caffeine citrate by half the amount of caffeine alkaloid, and the arsenic trioxidc by 0.025 om. of sodium arsenate (crystalline). Corrected Prescription: Lablo: Rx Ephedrin. Sulf. 4 Pot. lodid, 4 Caff. 4 Sod. Arsen. 023 Aq. Dest. qs 60 80 Capt. Stars. One (l) teaspoonful as directed. For March 32, 1940. Note: Sodium Arsenate N.F. is exsiccated and 0,015 Grn. equal 0.023 Gm. on crystals. 80a Rx Gm. or cc. Phenolphthal. 1 Sod. Bicarb, Lactosi aa 5 Ft. Chart, zv Sig. One b.d. No. 81 Form; Satisfactory. Official abbreviation and doses of active ingredients: Phenolphthal. 0.06 Gm. Sod. Bicarb. 0.35 Gm, Lactos. 0,55 Gm. Therapeutic Value; Phenolphihalein is a laxative. It is frequently prescribed in combination with sodium bicarbonate, which should make it more soluble, and less irritating. Incompatibility; Phonolphthalein is colorless in combination with pure sodium bicarbonate, but is colored pink by even a small amount of sodium carbonate. If there is any carbonate in the bicarbonate or if any of it is formed by decomposition of the bicarbonate, the powder will turn pink. Method of Compounding; Powder and mix the powders by trituration. Add a drop or two of a dilute solution of one of the alkali hydroxides or carbonates and triturate to a uniform pink color• Divide the powders, place in papers and fold. Each paper weighs 0.72 Gm. Corrected Prescription: Lable: No. 81 Gapt. Stars. One (l) powder twice a day. For 5-32-40 81a Rx Grn, or cc, Ferri Reducti Quin. Sulf. aa 2 Strych. Sulf. Arsen. Trioxid. aa 015 Ft. Mass. Div. in caps, no, xv. Sig, One (l) three (3) tines a day Fifteen minutes before eating. No. 82 Form; Satisfactory. Official, abbreviation and doses of active drugs Ferr, Reduct. 0.13 Gm. Quin, Sulf. 0,15 Gm. Strych. Sulf, 0.001 Gm. Arsen, Trioxid, 0.001 Gm. Therapeutic Value: A hena-tinic and stimulant tonic. Prescriptions similar to this one are frequently prescribed. It will be noted that the ingredients are similar to the familiar elixir, with the addition of arsenic. In some cases the addition of another metal has definitely proven of value in iron metabolism. Small amounts of copper salts are sometimes used in preparations for the same purpose. Incompatibility: None as written. Some prescribers will not permit preparations of reduced iron with potent ingredients in a powdered sta.te to be dis- pensed because of the danger of separation of the heavier iron by gravitation. Massing, of course, prevents any such separation. Method of Compounding: Dilute the strychnine and arsenic into the quinine sulfate by trit- uration, then add the reduced iron and 2 Gm, of extract of glycyrrhiza. Add water drop by drop until a stiff mass is formed. Roll into a cylinder, divide into 15 equal parts and place in frl capsules. Corrected Prescription: Rx Ferr. Reduct. Quin. Sulf. Ext.Glycyrrh. aa 2 Strych, Sulf, Arsen. Trioxid. aa 015 Ft.Mass.Div. in caps. xv. #1 caps. Lable: No. 82 Capt. Stars. One (l) capsule three (5) times a day, fifteen (15) uinutes befor eating. For March 32, 1940, 82a Rx Sod. Brondd. Aq. Camph. qs Ft. Sol, Sig. Tcasnoonful at night if restless. No. 05 Form; Satisfactory. Therapeutic Value: A sedative. Official abbreviations and doses of active ingredients: Sod. Bron. Aq. Careph. In compatibility: The solution is quite concentrated and throws the camphor out of solution. As the camphor is not present in a medicinal quantity in any case, the solution nay be filtered. If it were necessary to keep all of the camphor in the preparation, it would be necessary to increase the total quantity and the dose proportionately. Method of Compounding: Dissolve the sodium bromide and filter the solution. Corrected Prescription: Lablc: No. 85 Capt. Stars. One (1) teaspoonful in water at night, if restless. For I larch 32,1940, 83a Rx Gm. or cc. Quin. Sulf, 1 Hyd. Bichlor. 03 Liq. Pot. Arsenit. 2 Elix. Arom, qs 60 Ft. Mist. Sig. 3i t.i.d. No. 84 Form: The abbreviation ”Hyd.Bichlor.” is not above criticism; but there is no doubt as to what is meant. Official abbreviations and doses of active ingredients Quin. Sulf. 0,06 Gm. Hydrarg. Bichlor, 0.002 Gm, Liq. Pot. Arsen, 0,13 Gm, Elix. Arom. Therapeutic Value An alterative mixture, it is difficult to pick out any definite therapeutic action in so complex a preparation. Incompatibility; 1. There is an insufficient amount of solvent to dissolve the quinine sulfate. Z, Arsenites are reducing agents and in contact with mercuric chloride reduce it to mercurous chloride, especially in an alkaline medium. 3. Any excess of potassium bicarbonate will precipitate the mercury as carbonate. 4. Mercuric or mercurous arsenite is insoluble in the mixture. 5. Excess of alkali present precipitates quinine. It is likely that there is sufficient alcohol present to prevent this, however. Method of Compounding; The ideal method is to dispense the Fowler’s solution separately. In the event this is not possible, solution of arsenous acid should be substituted for it. The quinine is to be dissolved in 50 cc. of aromatic elixir with the aid of sufficient aromatic sulfuric acid (2 cc.) Dissolve 10 Gm. of acacia in the mixture, add the solution of arsenous acid, and the bichloride dissolved in water. Dispense with a shake lable,- a mixture of mercurous chloride and mercury arsonites precipi- tates but may be reincorporated to some extent by shaking. Corrected Prescription; Rx Quin Sulf 1 Acid.Sulfuric.Aron. 0 Kydrarg.Bi chior, 03 Liq. Acid. Arsen. 2 Elix. Arom. qs 80 Ft. Mist, Lable; No. G4 Dr. Stars SHAKE WELL BEFORE USING. One (l) teaspoonful three (3) times a day. 84a Rx Gn. or cc. Pot, Garb. 4 Ferri Sulf. 2 Glycerin! 1 Sucrosi 1 Ft. Mass. Div. in caps. no. xxv Sig. One t.i.d, between meals. No. 85 Form: Satisfactory. Official abbreviation and doses of active ingredients Pot. Garb. ) Ferr. Sulf. ) 0.06 Gn. ferrous carbonate per pill. Glycerin, Sucros. Therapeutic Value; Hematinic. Incompatibility; Potassium carbonate is intended to react with ferrous sulfate to form ferrous carbonate. Method of Compounding: Triturate the potassium carbonate in a mortar with the ferrous sulfate and glycerin until a uniform dark green mass or paste is formed. Add the sucrose near the end of the reaction. The excess of moisture comes from the water of crystallization of the ferrous sulfate. Sufficient inert insoluble powder should be added to make a mass. Calcium carbonate or powdered glycyrrhiza is suitable. The quantity as marked on the prescription. The mass is then rolled, cut, and encapsulated. Corrected Proscription; Rx Pot. Garb, 4 Ferr. Sulf. 2 Glycerin. 1 Sucrosi 1 Calc. Garb. 1 Ft. Mass. Div. in cap. no, xxv Lable: No. 85 Lt. Stars. One (l) capsule three (a) times a clay, between meals. For March.32,1940. 85a Rx Gm. or cc. Mass. Ferr. Garb. 5 Div. in cap. xx Sig. One t.i.d. #2 caps. No, 86 Form: Satisfactory. Official abbreviations and doses of active ingredients: Mass. Ferr. Garb, 0.25 Gm, Therapeutic value: Hematinic. Incompatibility: None. Method of Gompounding: Prepare the mass according to tne U.S.P. weigh out the 5 Gm., roll, divide and encapsulate. Use #2 capsule. Corrected Prescription: No corrections. Labis: No. 86 Capt. Stars. One (l) capsule three (3) times a day. For Liar. 32, 1940 86a Rx Quin. Sulf. Acid. Sulf. Aronu qs Ft. Pil. xv Sig. One t.i.d. No. 87 Fora; Satisfactory. Official abbreviations and doses of active ingredients Quin c Sulf. Acidc Sulfuric. Aron, Therapeutic Value: May be used for any of the various properties possessed by quinine. Incompatibility It is intended that quinine bisulfate be formed. Method of Compounding: To the uowdered quinine sulfate in a mortar, add aromatic sulfuric acid drop by drop until a mass of consistency suitable for pill making is obtained. Roll out the mass into a cylinder, cut it into lb equal parts and roll each into a round pill between the fingers. Corrected Prescription: No corrections. Lable: No. 87 Maj. Stars. One (1) pill three (o) tines a day. For I larch 32, IS 40. 87a For Jake Jacons Mar. 32, IG4O Rx Acid. Boric. 2 Quin. Sulf. 1 016 Theobrom. qs Ft, Suppos. Vag. M.T.D, viii Sig. One e. n. p. No. 88 Form: Satisfactory. The patients name hardly agrees with the kind of suppository, but otherwise there is no ambiguity. Official abbreviations and doses of active ingredients Acid. Boric. 2 Gn. Quin. Sulf. 1 Gn, Therapeutic Value: Antiseptic and in all probability, contraceptive. In c ompat ib ility: There is probably too much powder for the theobroma oil to hold in a firm mass. Suppositories so made will crumble. 0.5 cc, of olive oil or castor oil should be added. In any case, it will do necessary to make a .suppository weighing 5.0 Gm., at least, in order to have one which will hold together. Vaginal suppositories as large as this may be made the sane shape as a gelatin capsule. Method of Compounding: Mix the powders in a nortar by trituration. Add 0.5 cc. of olive oil per suppository, then 1.5 Gn. of theobrona oil per suppository and work into a mass by warning if necessary. When the nass is uniform ana of proper consistency, remove it from the nertar, roll to a cylinder on a pill tile and divide unto eight equal parts, flake a spherical suppository then elongate it by rolling until it is of a proper diameter. Corrected Prescription: Rx Acid. Boric. 2 Quin. Sulf. 1 01. Olivae 5 Theobrona Oil 1 5 Ft•suppos.vag. M. T.D.viii Sig. One e.n.p. Lablo; No. 63 Lt. Stars One suppository as directed. For Jake Jacons 1iar,32,1940 88a Rx Gm. or cc. Rhei Pot, Garb, Aloe. Sapo Dur, aa 1 Ft. Cap. xv Sig. One at night. #2 cap No. J3S_ Form: Satisfactory. Official abbreviations and doses of active ingredients: Rheum (no abbreviation) 0.06 Gm. Pot. Garb. O.OG Gm. Sapo Dur. 0,06 Gin. Aloe (no abbreviation) 0,06 Gm. Therapeutic Value; Laxative. Incompatibility: None. The potassium carbonate is added to render more soluble the resins in the rhubarb, especially. Method of Compounding: The fact that the prescription contains soap is the only indication the compounder has that a massed capsule is intended. The mixed ingred- ients, finely powdered and very slightly moistened, form an easily worked pill mass. The mass is then to be divided into 15 equal parts and placed into a ffZ capsule. Corrected Prescription; No correction. Lable: No. 89 Capt. Stars. One (1) capsule at night. For 3-62-40. 89a Rx Gra. or cc. Potassii lodidi 5 Salol qs Ft, pil. vel cap. xv, enteric coated. Sig. One q.i.d. No. SO Form; Salol is written in English, most of the remainder of the prescrip- tion is Latin, Official Abbreviations and doses of each active ingredient: Pot, lodid. Phenyl Salicyl. 0.33 Therapeutic Value; May be desired for any of the varied properties of potassium iodide'. The prescriber intends that the potassium iodide pass into the intestine before being absorbed, probably to prevent stomach irritation. Incompatibility None.. Method of compounding: Potassium iodide is a difficult substance to got into a piil mass. It is not easily powdered, and a very little water liquefies it so completely that a great deal of inert material must be used in order to make a workable mass. A small amount of theobroma oil makes a fair medium under ordinary conditions, but such a pill cannot be coated with salol. The easiest solution ?_s to encapsulate the pot- assium iodide and coat the capsules by rolling then in congealing salol. About two Gn. of salol will coat the 15 #2 capsules. The amount used should be marked on the prescription for future reference. Corrected Prescription: Lable: No. SO Capt. Stars, One (1) capsule four (4) tines a day. For ...March 32, 1940. Rx Pot. lodid. 5 Phenyl. Salicyl. (coating) 2 Ft, cap. xv enteric coated. #2 caps. 90a Rx Gnu or.cc, Phenobarbital Alcohol Dilute Hydrochloric Acid Tr. Gentian Comp, Elix, Pepsin Comp, qs/ad Sig, One tsp. after meals. No. 91 Form: Essentially satisfactory. The prescription is written in English, with the exception of Mqs/ad" and MSig.M The U.S.P, gives the titles as follows: Diluted Hydrochloric Acid, Compound Tincture of Gentian, and Compound Elixir of Pepsin. No English abbreviations are given in the U.S.P,; but that fact alone does not prohibit the use of abbreviations in a prescription written in English, "ad" is superfluous. Official abbreviations and doses of active ingredients; Phcnobarb, Alcohol (no abbreviation) Ac.Hydrochlor, Dil. Tr. Gentian. Co. Elix, Pepsin, Co, Therapeutic Value: A bitter digestive mixture, with phenobarbital added to give a sedative action on the stomach. There is little value in bitter mixtures used after meals. Incompatibilities: Hydrochloric acid precipitates extractive material from the compound tincture of gentian, especially in this mixture which is higher al- cohol than the tincture itself. Method of compounding: No way of preventing the precipitation is known. Moreover, the process is a slow one and filtration solves the problem only momentarily. The precipitate is readily suspended by agitation and does no harm. Dissolve the phenobarbital in the alcohol and compound tincture of gentian. Mix the diluted acid with the compound elixir and add this sol- ution to the phenobarbital mixture gradually. Dispense with a shake lable. Corrected Prescription: Lable: No. 91 Maj. Stars. Shake Tfcll Before Usinp;. One (l) teaspoonful after meals. For 1 larch 32, 1940. Rx Phenobarbital Alcohol Dil. Hydrochlor. Acid Comp. Tr, Gentian Compound Elix. Pepsin.qs Mix Sig. Ono tcaspoonful after meals. 91a Rx Gm. or cc. Sod. Sal. 39 Sod. Bicarb, 3 9 Syrup 6 0 Aq, Month, Pip. qs 60 Shake Sig. 4 cc. t.i.d. No. 92 Form: Intelligible enough, but a mixture of Latin and English. Sodium salicylate is more correctly abbreviated as shown below. Official abbreviations and doses of active ingredients; Sod. Salicyl. 0.25 Gm, Sod. Bicarb. 0.25 Gn. Syrup (no abbrev.) Aq. Menth. Pip. Therapeutic Value: An analgesic and alkaline mixture of a type frequently given in arthritis end neuritis. Incompatibilities; Sodium salicylate gradually darkens in alkaline solutions. It will become completely black if allowed to stand long enough* Method of Compounding; Various methods of compounding such mixtures have been originated; but all of them involve adding an active reducing agent or an acid, neither of which is indicated in a mixture already apt to prove nauseating. The quantity and dose of this mixture indicate that it mil be all consumed within 4 days, so the mixture may be dispensed as written with a shake lable, and a warning that if not soon used up it will darken. If the mixture were to be dispensed in large quantities, it -would be advisable to color it dark brown in the first place so that the change would not be so marked. Corrected Prescription: Lable: 92 Lt. Stars. Shake The Bottle. One- (l) teaspoonful three (3) tines a day. No. 92 3-32-40. Ibc Sod, Salicyl 3 9 Sod. Bicarb, 3 9 Syrupi 6 Aq. Menth. Pip. qs 60 Nix. Sig. Shake. 4 cc. t.l.d. 92a Rx Gm, or cc. Hydrous Wool Fat 5 Glycorite of Boroglycerin 15 Petrolatum qs SO V i