Endometritis Fungosa ITS PATHOLOGY, DIAGNOSIS, AND TRE A TMENT BY JAMES B. HUNTER, M. D. SURGEON TO THE WOMAN'S HOSPITAL, NEW YORK ; PROFESSOR OF GYNECOLOGY IN THE NEW YORK POLYCLINIC, ETC. Reprinted from The Medical Record, April 25, 1885 NEW YORK TROW'S PRINTING AND BOOKBINDING CO. 201-213 East Twelfth Street 1885 Endometritis Fungosa ITS PATHOLOGY, DIAGNOSIS, AND TRE A TMENT BY JAMES B. HUNTER, M. D. SURGEON TO THE WOMAN'S HOSPITAL, NEW YORK ; PROFESSOR OF GYNECOLOGY IN THE NEW YORK POLYCLINIC, ETC. Reprinted from The Medical Record, April 25, 1885 NEW YORK TROW'S PRINTING AND BOOKBINDING CO. 201-213 East Twelfth Street I88S ENDOMETRITIS FUNGOSA ; ITS PATHOLOGY, DIAGNOSIS, AND TREATMENT.1 The disease known to us as endometritis fungosa was described by Robert, a pupil of Recamier {Bill. Therapeut., 1846, tome 21). Recamier himself wrote on the sub- ject, under the title of " Fongositees Uterines," in 1850 {Union Med de Paris, tome 1, 1850). In 1848 Robin {Arch. Gen. de Medicine, xvii.) said of these fungosities: They are, from an anatomical standpoint, simple vegeta- tions from the uterine mucous membrane, having therefore the same anatomical composition, and enclosing fibro- plastic tissue." Rouyer ("These de Paris, 1848") says: "The frag- ments made with a curette are generally from three to five centimetres long ; from five to six millimetres wide, and from one to five millimetres thick. Their free sur- face is smooth, and covered with epithelium ; the tissue is very vascular. In this hypertrophied mucous mem- brane there appear granular forms of three kinds, viz. : 1, Granules which resemble small gooseberry seeds, and are opacpie or transparent-these raise up the mucous membrane, and form white spherical, almost sessile, pro- jections ; 2, masses of a spongy character, like placental tissue ; 3, granules about as large as the head of a pin, which are seen beneath the mucous membrane. These may attain the size of a pea, and resemble the forms described, except that they are more numerous and regu- larly distributed. Nelaton {Gazette des Hopitaux, 1853, No. 17), states 1 Read before the New York Academy of Medicine, April 16, 1885. 4 that fungosities have two surfaces-a free surface, which is of a rosy red color, and growths resembling the intes- tinal villi, and an attached surface, the latter having a deep red shade, and suggesting freshly torn tissue. Fenier ("Th^se de Paris, 1853") had an opportunity to observe these growths in situ, on several occasions, in the dead-house. He describes them as small, spongy, pulpy masses, red or rose-colored, soft, easily detached with the finger-nail, with or without pedicles. Goldschmidt (" These de Strasburg, 1859 ") states that Koeberle found them fifteen times in the cadaver. Richet, Robert, and Nelaton all took opportunities to study this condition at autopsies. For the gross pathol- ogy of this affection we are indebted largely to early French observers, and some after them recognized its nature quite clearly. The German authorities have in- vestigated more thoroughly the microscopical anatomy of the subject; Olshausen (Archiv fur Gynakologie, vol. viii., No. 1) having contributed the most important paper. Among those who have written on the subject are Aran (" Mal. de 1'Uterus") ; Courty (" Mal. de 1'Uterus"); Gallard, Ruge and Veit; Nonat ("Mal. de 1'Uterus ") ; and Winckel, under the title of " Adenoma Papillosum Diffusum Corporis Uteri." The disease does not seem to have been studied or appreciated by the English authori- ties. In this country it has long been recognized and successfully treated. There is some confusion as to the term " fungosity." Olshausen writes of " endometritis hyperplastica chronica vel polyposa ; " Hegar and Kaltenbach include the con- dition under "endometritis;" Weber refers to it as " endometritis hemorrhagica ; " Slavjansky employs the term " metritis villosa ; " Courty treats of granulations and fungosities, and considers fungosilies a development of granulations. Throughout his whole chapter on this subject, Courty singularly confounds fungosities of the uterine cavity with erosions, and with hypertrophy of the follicles of the cervix. According to my experience 5 fungosities proper are never found in the canal of the cervix, though often abundant just above the boundary- line between the cervix and the body of the uterus. They are certainly never found, as Cdurty seems to be- lieve, " commencing at the os uteri." Pathology.-If the lining membrane of a uterus which is the subject of fungosities be gently scraped with a blunt curette there will appear, together with some blood-clots, a number of small, pink, firmly organized bodies, sometimes gelatinous, resembling small polypi, and varying from the size of a pin's head to that of a small pea. I have seldom found them to exceed five millimetres in size, and, as a rule, they are much smaller. They cannot be easily broken down by the finger, and are very easily distinguished from blood-clots when put into water. Neither the size of these growths nor their number is in proportion to the amount of hemorrhage to which they may give rise. The scraping, if carried over tjie whole surface of the uterus, will generally exhibit a few whole fungosities and a quan- tity of fragments, mixed with blood-clots. The true fungosity is always of a pale pink color after removal, but is probably congested while attached to the mucous membrane of the uterus, as the structure is highly vas- cular. Aran divides fungosities into sessile tumors, with broad bases, and pediculated or polypoid masses. Munde {Edin. Med. Jour., April, 1878) speaks of three varieties, including " uniform hyperplasia of the entire mucous membrane," which, pathologically speaking, is questionable. The difference between sessile and pedi- culated fungosities is one of form only. All fungosities consist essentially of a hypertrophy of the muco'. s mem- brane, in the form of papillary growths having a distinct fibrous basis, and covered by a single layer of cylindrical epithelial cells. I have examined a large number of specimens microscopically, and have often found these characteristics so distinct, and accompanied by so great an increase in the size of follicles, as to offer some ground for considering them new specimens, which might be re- garded as adeno-papillomata. The abundant vascular 6 supply of these fungosities has been well described by Olshausen, who also notes the constant presence of num- bers of leucocytes, which not only crowd the interstices of the fibrous tissue which forms the bulk of the fungosities, but are also found abundantly in the surrounding mucous membrane. The presence of these white blood-corpus- cles in unstained specimens often gives an appearance which it is extremely difficult to distinguish from that of round-celled sarcoma. De Sin^ty (Paris, 1879) is the only author who has laid stress upon the close resem- blances of fungosities to true granulation tissue. He says : " In other cases the fungosities are specially con- stituted of embryonic tissue with few blood-vessels. There are only traces of the glands, and some remains of more or less degenerated epithelium. We have then to do with a truly inflammatory tissue, and comparable to that which remains upon an exposed wound. At certain points there are islands of degenerated elements which are not colored by reagents, and are analogous to those observed in foci producing pus." This statement is im- portant, as showing that we have to deal with something more than simple hypertrophy. Thomas, in using the term " fungous degeneration," does not mean to imply that there is any process akin to degeneration in the de- velopment of fungosities, which are really local hyper- trophies of the uterine mucous membrane. Fungosities are never friable, and never show evidences of degenera- tion. They are not homogeneous on section, and con- tain a good deal of fibrous tissue. The question naturally arises, why the hemorrhage should be so great, as we know it to be clinically, from a cause apparently so trifling. The amount of hemorrhage will not appear excessive if we consider the extent of surface from which it springs. In normal menstruation the escape of blood occurs because of the fatty degenera- tion of a portion or of the whole of the epithelial lining of the uterus (Kundrat, Leopold, Engelmann). The epi- thelial covering of these fungosities probably undergoes the same change as that of the rest of the mucous mem- 7 brane. In the diagram before you, which is probably not exaggerated as to proportion, the distance from A to B is about six inches. The surface of this fungosity measures ninety-six inches ; so that it is evident that the superficial area of the cavity of the uterus may be enormously increased by the existence of a small num- ber of fungous growths. The extreme vascularity of the growths under consideration is not apparent in sections of specimens that have not been injected. The oppor- tunity for obtaining such specimens is very rare. The question of the cause of the prominent symptom, hemor- rhage, has been avoided by all the authors I have con- sulted who have written on this subject. Microscopic appearances.-The actual appearance of these growths under the microscope has not been satis- factorily described, notwithstanding the vital importance of distinguishing between endometritis fungosa and ma- lignant disease of the uterus. Unaided by the history and clinical features of a given case it is not always pos- sible, by the microscope, from a single small specimen, to make an absolute diagnosis, even for the most experi- enced microscopists. In a typical case, and under favorable circumstances, there would be little difficulty in doing so. While a diagnosis of sarcoma or epithe- lioma may often be made from the examination of a single specimen, it may be necessary to examine a num- ber of specimens in order to certainly exclude those dis- eases and pronounce a diagnosis of an innocent affec- tion. The papillomatous masses are absolutely characteristic of fungosities, even if there should be no enlarged glands and other appearances characteristic of uterine mucous membrane. This, taken in connection with the amount of fibrous tissue, the glands, etc., will generally suffice for a diagnosis. On staining, the smaller size and irregu- lar distribution of the leucocytes will exclude sarcoma- tous tissue. In cases where characteristic sections can- not be obtained the diagnosis must be guarded. According to Olshausen, microscopical examination 8 shows a greatly hypertrophied mucous membrane with increase of all its elements, dilated follicles, enlarged blood-vessels, and great cell infiltration of all the connec- tive-tissue. There are large dilated blood-vessels, and around them many white blood-corpuscles. Around the i follicles are spindle-cells arranged in regular lines. "These," he says, "prove the chronicity of the affection." I have quite recentlyhad an opportunity of examining, post-mortem, a perfect specimen of fungosities in situ that presented the appearance of very small dentritic masses, pale and shrunken, covering the greater part of the anterior wall of the uterus. A number of sections made by Dr. H. C. Coe, through the entire uterine wall of a similar case, including the basis of the growths, showed conclusively that there was no line of demarca- tion between the normal hypertrophied tissue, but that the uterine mucous membrane was continuous with that covering the fungoid masses. The submuqous connec- tive-tissue extended directly into the masses, giving an appearance suggestive of the benign growths in the blad- der figured by Thompson as " fibro-papillomata." Important as the microscope is to enable us to form a diagnosis of this affection, much care and patience is necessary in its use. A hasty examination of a single section, especially a fresh one, is by no means sufficient. Specimens should be examined both fresh, and also hard- ened in alcohol, and stained. At least a dozen different sections should be looked over carefully and compared with each other, or other specimens and plates. Such an examination, together with the history of the case, will generally enable us to make a positive diagnosis. Symptoms.-The principal symptom of this form of endometritis is menorrhagia. Rouyer makes the ques- tionable statement that pain is always present, and that it is generally unilateral, radiating from the iliac region to the sacrum and hip of the corresponding side. I have found pain to be rare as a consequence of the existence of fungosities. As a rule, the hemorrhage consequent upon fungous growths is a menorrhagia-that is, it con- 9 sists in an increase of the quantity of the normal men- strual flow, and especially in a lengthening of the period, which instead of five may last eight or ten days or more. In sarcoma there is generally a metrorrhagia, which occurs independently of the menstrual period, and which often breaks up entirely the menstrual rhythm. A long train of symptoms follow, but they are in nowise different from those common to anaemia from other cases. In some cases there is in place of hemorrhage a con- stant discharge of serum, perhaps only tinged with blood. The subjects of such watery discharges lose flesh and strength and become anaemic, as though the loss were of blood. According to Olshausen the increased flow due to fungosities often comes on suddenly in women previously healthy, and causes an anaemia, as a result of which there is an absence of menstruation for several months. This is directly contrary to my experience. Lusk reports a case {Am. Jour. of Ob stet., January, 1878) which died from progressive cachexia, probably from the existence of fungosities. Dr. M. D. Mann, who exam- ined the uterus, post-mortem, pronounced the case one of " villous degeneration of the uterine mucous mem- brane." He says of the specimen examined (Trans. Obstet. Soc., Am. Jour. Obstet., January, 1878, p. 133), " it consists histologically of structureless basement sub- stance containing great quantities of small round cells and nuclei, and portions of uterine follicles and vessels." Etiology.-The growth of fungosities seems to be gen- erally a result of chronic congestion of the uterus. It is commonly found in cases of subinvolution. In unmar- ried women it is often a consequence of neglected retro- version or retroflexion. In cases of laceration of the cervix, where there is much hypertrophy of tissue, there is commonly an interference with the circulation, which, if sufficiently prolonged, promotes these vascular growths from the endometrium. They seem to result from a moderate amount of congestion, as from a mild form of endometritis, long continued, rather than from the more 10 severe or acute forms of that disease. They have no connection whatever with gonorrhceal or syphilitic infec- tion, as far as I have been able to ascertain. They oc- cur usually during the child-bearing period, but may be found before and after that time. It is some aid in di- agnosis to remember that sarcoma, as a rule, does not occur till between thirty-five and forty. One of the causes of hyperaemia of the uterus is the existence of fibroid tumors in connection with that organ. Hence fungosities are often found associated with fibroid tumors, and in some cases are the chief cause of excessive hemorrhage. They should always be suspected in cases of fibroids, as their removal may be of great temporary benefit to the patient. Differential diagnosis.-The conditions with which fungosities are liable to be confounded are : i. Benign growths, A. Submucous polypus; B. Adenoma of the uterus ; C. Benign papillomata; D. Villous degeneration of the endometrium ; E. Placental or decidual remains. 2. Malignant growths, A. Carcinoma of the body of the uterus ; B. Round celled (or diffuse) sarcoma. Benign Growths.-A. Fragments of soft myxomatous polypi removed from the uterine cavity sometimes resem- ble fungosities on gross inspection. Under the microscope the loose fibro-muscular tissue, the enclosing layer of epi- thelial cells, the enlarged blood-cells, and the free leuco- cytes give an appearance which might easily be mistaken. A few stained sections of the suspicious masses will bring out the well marked papillary remains, and clear up the diagnosis. The rare form known as " channelled poly- pus" is distinguished by the presence of a large number of cavities of a size never seen in true fungosities. Klob describes a vesicular polypus which seems to be of the same character as the variety just named. Polypi are more limited in number, and more localized. They are often found in the cervix, while fungosities are not. B. Adenoma of the uterus is a rare condition, and the descriptions of it are vague. Savage seems to regard it 11 as not uncommon, but he evidently confounds it with fun- gosities. C. True benign papillomata are said to be confined to the cervix, while fungosities are, in the opinion of all authors except Courty, limited to the body of the uterus. The microscopical differentiation of these two conditions would be difficult, if not impossible. It is a question whether some of the large fungoid growths should not be regarded as true morbid growths rather than simple hypertrophies. D. Goodell refers to a condition which he calls vil- lous degeneration of the endometrium, the same being described by Hirschfeld as " cylindrical cell adenoma," and by Winkel as " adenoma papillosum diffusum corpus uteri." The cases described by Goodell were probably either villous cancer or simple fungosities. E. The diagnosis of fragments of placental polypi or retained decidual remains is not easy. The embryonic cells of foetal remains are larger than those covering the fungoid masses. The cells covering fungoid masses are cylindrical, and the connective-tissue basis is firmer and more pronounced than in the chorionic villi. The latter are generally longer and more delicate, and have clubbed rather than accuminate extremities. Malignant Growths.-A. Epithelial or medullary carci- noma of the body of the uterus is so different in its history, and so different microscopically, that there is little danger of confusion. The cells of an epithelial type, infiltration, excessive degeneration, alveoli, fragments, etc., are suffi- cient to make the diagnosis of carcinoma easy. B. Round-celled sarcoma of the uterine mucous mem- brane is more likely to be mistaken for fungosities than any other condition. Sarcoma of the body of the uterus is not so exceedingly rare as it is stated to be by Dr. Munde in his article already quoted, in which he says that Schroeder has found only sixteen cases re- ported in literature. I have seen seven cases in my own practice, and in that of Dr. Thomas, in the Woman's Hospital and elsewhere, I have seen twice as many. Dr. 12 Coe, Pathologist to the Woman's Hospital, has examined six cases, in which there could be no doubt of the diag- nosis, within the present year. Munde believes that localized fibro-sarcoma (the hard variety) is the more frequent. In this iny own experience is not in accord- ance with his. I believe sarcoma is not so very uncom- mon, but that it is often overlooked ; and it should al- ways be suspected in cases where we exclude fungosities and carcinoma. The symptoms of sarcoma may be very similar. Virchow (" Onkologie," vol. ii., p. 350) thinks many innocent hyperplasias of the mucous membrane are mistaken for sarcoma, but he gives no differential diag- nosis. In sarcoma scraping generally yields a consider- able quantity of soft, brain-like material, breaking down readily upon handling, homogeneous on section, fre- quently showing marked degeneration (pus, etc.). It never appears in distinct formations, but the fragments are always irregular in shape, whatever their size may be. The difference is marked, even to the naked eye, and is rendered very distinct by a lens of low power. Microscopically sarcomatous tissue is homogeneous in appearance, being entirely made up of round cells with a fine stroma. The cells are mostly somewhat larger than leucocytes and have a large central nucleus. Transi- tional forms, "alveolar sarcoma," "sarcoma carcinoma- todes," may be found in the uterus, the cells assuming an epithelial type, and being arranged in alveoli. These appearances are of course never seen in fungosities. In the examination of fresh and unstained specimens there is a liability of error, because in both cases the field is filled with masses of round cells. Differential Diagnosis. Symptoms. Little or no pain. Menorrhagia the rule, metrorrha- gia the exception. Discharge generally odorless. Fungosities. Considerable pain. Menorrhagia and metrorrhagia us- ual. Discharge often offensive. Sarcoma. 13 Fungosities. Gross Appearances. Sarcoma. Pale pink color, semi-transparent, sometimes gelatinous. Distinct formations, of firm con- sistency ; undergo no degenera- tion. Grayish white, brain-like. Soft, friable, amorphous, and prone to degeneration. Microscopical Appearances. Single layer of normal columnar epithelium and irregular groups of leucocytes. Stroma considerable and not in- tercellular. Papillomatous arrangement. No infiltration of healthy tissue. Surrounding mucous membrane normal. Structure entirely cellular, single nuclei. Stroma slight and intercellular. No papillomatous arrangement. Healthy tissue invaded. Surrounding mucous membrane destroyed. Clinical differences between fungosities and sarcoma. -The thorough use of the curette in cases of fungosi- ties is followed by little or no hemorrhage. If the case is one of sarcoma, there is apt to be much bleeding for several days after the use of the curette, the condition of the patient is aggravated rather than improved, and there may be considerable pain lasting for several days. In case of simple fungosities, if they are thoroughly re- moved by the curette, and if the cause of the congestion of the mucous membrane be remedied, the patient is often permanently cured after a few months. In sarcoma similar treatment is of no avail whatever to arrest the tendency to hemorrhage, nor does the patient in the lat- ter case improve much under tonics, food, and general hygienic measures. Fungosities recur after six or eight months if the original cause remains, but for a period the patient is free from hemorrhage, and gains health rap- idly. Sarcoma recurs after removal, and after mere scraping with a blunt curette it often assumes a rapid growth. Treatment.-The disease having been recognized and a positive diagnosis made, the treatment of the existing condition-the fungosities-is very simple and satisfac- tory. The cure of the condition that gives rise to a hy- peraemic condition of the uterus is a very different and 14 much more tedious affair, and must obviously be adapted to each individual case. • It is not usually necessary to dilate the canal of the cervix in order to use the curette. The presence of any growth or body within the uterus tends to cause a patu- lous condition of the cervical canal. The operation of curetting should be done under the influence of ether. The patient being on the side, a Sims speculum is intro- duced, and the canal of the uterus is cleansed by the use of cotton on the ordinary applicators. The whole surface of the uterus is then gently scraped with the blunt curette, the curve of the instrument being changed so as to enable every part of the cavity to be reached. Cotton should again be used to remove the loose fungosi- ties and to cleanse the uterus. An application of the strong tincture of iodine (Churchill's), or of strong car- bolic acid, should then be made tb the whole surface, a little absorbent cotton placed in the vagina, and the pa- tient put directly to bed, where she should remain for two days, or longer if there be any pain. The operation may be done without anaesthetics, but it is almost always painful, and it is not likely to be done so thoroughly. Apart from the effect of the curette on the growths in the cavity of the uterus, it has an excellent effect on the congested uterine mucous membrane, and has been re- commended as a means of cure. Diirelius, assistant to Martin, of Berlin, reports sixty cases of pregnancy, oc- curring in women who had been curetted-forty-nine of them for endometritis. Dr. Clinton Cushing, of San Francisco (Western Lan- cet, August, 1882, p. 340), recommends the blunt curette in the treatment of hemorrhage from congestion of the uterus, and considers it especially valuable in cases of hyperplasia of the body of the uterus, or subinvolution, its use in such cases being followed by marked improvement. Patients should be warned not to expect immediate improvement. The first period after curetting is often quite profuse, and it is not till the second or third that there is marked improvement. 15 If done only in suitable cases, with due preparation, proper regard to cleanliness, and with antiseptic pre- cautions, and if the patient is put in bed immediately afterward, and kept quiet by morphine if there is much pain, I consider the operation of curetting little more hazardous than the passage of the uterine sound, which in certain fare cases has proved exceedingly dangerous. Contra-indications.-The curette is on no account to be used in case of recent pelvic inflammation or any degree of parametritis. Nor should it be used without thorough preparation in cases where the uterus is so sensitive that it will not tolerate the passage of the smallest probe. Such cases should be prepared by the abundant use of hot water, and should be watched very closely after the operation. The czirette.-A few words in conclusion as to the instrument known as the curette. Recamier's curette, though not described by him in his article on fungosities in 1850, was doubtless a cutting instrument. It was first a steel scoop, and afterward a loop of flat steel, sharpened on each side. It has recently been claimed in England that Recamier's instrument was blunt, but no evidence is given in support of the state- ment. Recamier speaks of it himself as the sonde curette^ and speaks of taking out with it a tablespoonful of fun- gosities. He refers to the operation as la cath'eterisme uterine. He speaks of having first used the curette, and then having applied the cautery, and also of hav- ing had unpleasant symptoms afterward. He reports the removal of a fibrous polypus by means of his instru- ment. The introduction of the curette met with much opposition, and Recamier seems inclined either to apolo- gize for it, or to stand on the defensive. Trousseau {Gazette des Hopiteaux, 1856) says the in- strument was so sharp that Recamier perforated the uterus with it on three occasions. Olshausen condemns Recamier's instrument as danger- ous, and recommends that of Sims; he speaks of Recamier as being very harsh in his methods.' Both Sims' and Simon's curettes were of steel, and 16 had sharp cutting edges. About the year 1870 Dr. Thomas devised the blunt curette, and with slight modi- fications in shape that instrument has been very gener- ally adopted in this country. It has nothing in common with the sharp curette except the name. The name be- ing derived from the French verb curer, to cleanse, is more appropriate to this instrument than to one capa- ble of cutting. The introduction of this blunt curette has made the treatment of ordinary fungosities safe and simple. For general purposes the blunt curette should be of two sizes. The smaller one is an oval loop, one-fourth of an inch wide, outside measurement. This is used chiefly for diagnostic purposes. The larger one is three- eighths of an inch wide. Both are made of copper or soft metal, with a shank that can be adapted to the curve of the uterine canal, the entire handle being nine inches long. For obstetrical purposes they are made larger, and with much longer handles. Many modifica- tions of the blunt curette have been recommended, but the bluntness is the essential feature of Thomas' instru- ment, and so long as that is preserved the precise shape of the instrument is of little consequence, provided it will reach every portion of the uterine cavity without the use of force. Emmet's curette forceps is a different in- strument, and is intended to crush the fungosities without the possibility of danger to the healthy tissue. It was devised to avoid the evils sometimes consequent on even the most careful application of the sharp curette. Those dangers do not belong to the blunt curette, which, as has been said before, with proper care can do no more mis- chief than the passage of the sound. The therapeutic uses of the blunt curette were fully discussed by Dr. Munde in a paper published in the Edinburgh Medical Journal in 1878. A paper on the same subject was read by Dr. George T. Harrison before the New York State Medical Association, November 19, 1884, and published in the New York Medical Journal, December 20, 1884, and is, as far as I know, the latest addition to our scanty literature on this subject.