[Reprinted from the Transactions of the Philadelphia County Medical Society.] ABDOMINAL SURGERY AT THE KENSINGTON HOSPITAL FOR WOMEN. CHARLES P. NOBLE, M.D., SURGEON IN CHAR&J^ [Read April 8,1891.] The following report embraces all cases of abdominal section done in the Kensington Hospital for Women during my connection with it. Cases of hernia, forming a special class, are excluded. The number of operations is eighty-five, being the work of three opera- tors-Drs. Kelly, Robb, and myself. As it is manifestly impossible to report these cases in detail, they will be given in groups, with com- ments on the nature of each class. And, to add to the practical value of the report, I will give the lessons I have learned and the impression I have formed from the study of these cases. Selection of Cases for Operation.-Certain definite princi- ples have been followed in the selection of cases for operation. Operation has been recommended in all cases of ovarian and par- ovarian tumors, ovarian abscess, pyosalpinx, hsemato-salpinx, and of hydro-salpinx unless organic disease of the vital organs clearly for- bade it; also in cases of fibroid tumor of the uterus in which hemor- rhage or pressure symptoms demanded it; also in cases of extra- uterine pregnancy, both before and after rupture; also in certain cases of simple salpingitis and ovaritis in which well-directed treatment, long continued, failed of relief, and in which life was made burdensome by the continuance of the disease. Operation has been refused only in cases of serious kidney disease or of advanced cancer. Treatment of Patient Before Operation.-Whenever prac- ticable, for a week prior to operation patients have been put upon simple food, the bowels gently purged, and the skin made clean and active by warm baths given daily or on alternate days. This regimen is considered especially important for cachectic women with sluggish 2 NOBLE, emunctories. When time is precious a purge is given, and a thor- ough bath. As my experience grows, I become more convinced of the advantage of preparatory treatment entending over weeks or months in chronic broken-down cases. The nutrition of such cases should be improved in every way; and the state of their emunctories be carefully studied. In acute cases, if operation is to be done, all delay is pernicious. Before operation the abdomen is scrubbed with soap and water, alcohol, and sublimate solution 1:1000. Preparation for Operation.-I believe that the essentials for success in abdominal operations are asepsis, rapid, careful, and thor- ough operating, thorough irrigation in septic cases, and drainage. To secure asepsis an elaborate technique is faithfully followed. The doctrine that infection comes by contact is fully believed ; hence every- thing coming in contact with the patient is rendered aseptic. Treatment of the Hands and Arms.-The hands and arms of the surgeon and assistants are washed carefully through three waters, a good lather being made with soap, and the nail-brush vigor- ously applied; especial attention is given to the subungual spaces. Ten minutes are consumed in the process. The hands are them im- mersed in a saturated solution of permanganate of potassium, next in a saturated solution of oxalic acid to remove the permanganate, and, finally, in a 1 :1000 solution of corrosive sublimate, in which they remain three minutes. Whenever the skin about the fingers is chapped, or the hands have been recently exposed to septic material, the fingers are soaked in peroxide of hydrogen solution before the sublimate bath is used. Dressings.-Gauze is prepared by tearing cheese-cloth in squares of one yard, which are boiled in a solution of carbonate of sodium two drachms to water one gallon, for twenty minutes; then washed through pure boiled water four times; wrung out and soaked in sub- limate .solution 1 : 500 for one hour; then preserved in alcohol. Before use it is washed in sterilized water. Silk is prepared by winding Chinese silk on spools; boiling it for twenty minutes; soaking it for three hours in sublimate solution 1:1000 ; and preserving it in 4 per cent, carbolized alcohol. Before each operation it is boiled fifteen minutes. In the future I propose to sterilize it in the steam sterilizer. Catgut is prepared by heating it in the hot-air sterilizer for four hours, gradually increasing the heat to 280° F. The last half-hour 3 ABDOMINAL SURGERY. the heat varies from 250° F. to 280° F. It is then preserved in carbolized alcohol 4 per cent. Sponges are prepared by-beating to get rid of dust; soaking in hydrochloric acid one drachm to water one pint for from twelve to twenty-four hours; washing through twelve to sixteen waters, until the water ceases to look yellow; soaking in sublimate solution 1:1000 for twelve hours; when they are transferred to carbolic acid solution, 4 per cent., for preservation. Varying qualities of sponges are used, from the reef sponge to the potter's sponge, the cost varying from one to fifty cents each. The coarse sponges are bleached by " White's method " before they are washed. Before using them, sponges are washed in boiled water, and are used but once. By exercising some care the average cost for sponges for each operation will not exceed fifteen cents. In comparison with the assurance of always having aseptic sponges this is nothing. Instruments are kept aseptic. Before each operation they are sterilized in an Arnold's steam sterilizer for an hour. Formerly a Rohrbeck's dry hot-air oven was used, temperature 250° F. to 300° F., for two hours.' This heat spoils the temper of steel instruments. After a clean operation the instruments are thoroughly washed and scalded, special attention being paid to the French joints and irregu- larities. After a septic operation the instruments are sterilized, after washing, for one hour, then dried and put away. Basins and trays before operation are thoroughly washed with soap and water, scalded, and washed with sublimate solution. They are then filled with boiling water. After operation the same process is repeated, and after septic operations they soak over night in sub- limate solution. Towels used about the patient have been preserved in 4 per cent, carbolic acid solution, or have been freshly sterilized with steam. The Nurse.-The nurse for the operation is kept away from septic cases, should such be in the hospital. She has a bath and a fresh suit before entering the room. The Operating-room.-Formerly, when the hospital had no operating-room, the room selected was scrubbed and aired for twenty- four hours. Then the woodwork was wiped with sublimate solution 1:1000. All tables were likewise wiped with sublimate solution. Now, with a model operating-room, having tiled floor and walls, abundant light and special ventilation, the walls are wiped, and the floor scrubbed and flushed with water, which runs into an open roof- spout; thus obviating a sewer connection. After foul operations 4 NOBLE-, sublimate solution will be used. Every facility for obtaining and maintaining cleanliness and asepsis is afforded by the apparatus in the room. Wash-basins with an abundance of running water for washing the hands, and instruments and basins, are very convenient. The room, when in use, is protected against sewer-gas by the best modern plumbing used throughout the building; while the waste-pipe leading from the operating-room is doubly ventilated. Further protection is afforded by the modern traps. Between operating days the waste- pipe from the operating-room is shut off from the sewer by an air-tight valve. Thus a maximum protection is afforded against septic hands, instruments and appliances, with a minimum danger of atmospheric pollution. Clean water is obtained by the use of the Pasteur filter; and this is sterilized in a jacketed kettle heated by steam from the boiler. In this way an abundance of sterilized water is assured. The room is warmed with steam by the system of indirect radia- tion, and is ventilated by a warm ventilating flue. The temperature is kept at 75° F. Operation. Anaesthetic.-Ether was used formerly for all cases. Various bad results have made me believe that chloroform is a better anaesthetic for the abdominal surgeon. At the present time I do not use ether in old women, nor when bronchitis, nephritis, or organic heart disease exists. I have found cachectic subjects, " wrecks," and fat women to take ether badly. The anaesthetic is given late, so that the operator waits for the patient rather than the patient for the operator. I believe anaesthesia in itself to be dangerous, and that the danger increases with the duration of the anaesthesia. The Allis inhaler is used for ether; the Esmarch inhaler for chloroform. From ether I have had " collapse " once; pneumonia once; bronchitis twice; uraemia and death twice. From chloroform, "collapse" once; uraemia and death once. Technique of Operation.-The technique employed is not pecu- liar. I believe in rapid, careful, and thorough work. This is shown by the fact that only two exploratory operations are found in the list. No chemical antiseptics are used during operation. The instru- ments and sponges are kept in sterilized water. Toilet of Peritoneum.-In non-septic cases, such as simple ovarian tumors, the peritoneum is simply sponged dry before closing the wound. In these cases the aseptic technique employed completely fills every scientific requirement. No sepsis is in the peritoneum before operation; none is introduced during operation; hence none is present after operation. ABDOMINAL SURGERY. 5 In septic operations, including pus accumulations, hsemato- and hydro-salpinx, more or less irrigation is used. If the presence of sepsis be doubtful, as, for instance, from the escape of some fluid from a hydro-salpinx, water is poured into the pelvis, and it is sponged dry. If septic matter has escaped into the pelvis in small amount, the pelvis is irrigated with sterilized water by means of the Davidson syringe-care being taken to protect the general peritoneal cavity. When large amounts of septic material are to be removed, I use the " flusher " and irrigate the entire peritoneum with gallons of water. This process requires time, and entails shock. I do not like it alto- gether, yet know of no substitute. In septic cases the scientific requirements are not met by an aseptic technique. The flusher may disseminate the septic matter throughout the peritoneal cavity. Moreover, when plain sterilized water is used, septic foci in the belly are not disinfected. Yet, practically, the results obtained in such cases by asepsis with free irrigation and drainage are much better than by the use of chemical solutions to disinfect the peritoneal cavity. Hence, until some disinfectant is discovered which will kill germs without irritating the peritoneum, the present plan must be adhered to. I only use sublimate solution in the belly to disinfect a limited area, such as a pedicle. It should be used on a sponge spar- ingly. The peroxide of hydrogen may prove useful for this purpose. Ligatures and Sutures.-In abdominal surgery aseptic silk is the best material for ligatures and sutures. Drainage.-Drainage is necessary for safety in all cases having dense adhesions; and I believe it is always of advantage. I use it in almost every case. When the drainage-tube is properly cared for, I believe that there is no objection which can be urged against it. The plea that it favors hernia is apparently an objection; but it only favors hernia when left in a long time, and it is only left in a long time in cases in which there is excessive drainage; cases which would frequently die without it. Such women should be glad to have a hernia-it is hernia or death. Of the 85 cases reported, 77 were drained, and 8 were not drained. Dressing.-After the incision is sutured the abdominal wall is washed with sublimate solution, and a wet sublimate gauze dressing is applied. A layer of cotton is applied over this; and the whole is held in position by a Scultetus bandage. The drainage-tube is buried in the cotton, and the bandage is.applied over all. Rubber- dam is used about the tube only in cases in which an excessive flow is expected. 6 NOBLE, During the operation the patient's legs are wrapped in a blanket, and her underclothing is protected by covering with towels. The use of the Kelly pad to drain away all fluid is, also, of the greatest assist- ance in keeping the clothing dry. After opeiation the patient is put in a bed which has been warmed with hot-water cans. The cans remain ; care being taken to avoid burning the patient. Shock and Collapse.-One patient has " collapsed " from ether, and one from chloroform. There was distinct paralysis of respiration in each case. The collapse from chloroform was the more profound. The lower end of the table wTas elevated immediately; the chin drawn forward; artificial respiration by Sylvester's method kept up ; and hypodermics of strychnia solution and tincture of digitalis given. In the chloroform case, in addition, ether and brandy were given hypodermically, and the faradic current was used over the phrenic nerve. These methods were used in the order in which I estimate their value. I may say that drawing' the chin forward is not Howard's method. It has been used in Baltimore for many years, and was in constant use from 1882 to 1884. For shock on the operating-table strychnia and digitalis have been used; at times whiskey. Careful anaesthesia and quick operation are the best preventives. After-treatment.-In the majority of cases this is simple. Nothing is given for twenty-four hours. One drachm of water every half-hour is given the second day. Two to four times this amount is given the third day, with milk and lime-water of each one drachm, or two drachms of beef-tea, every half-hour. These amounts are rapidly increased, and the frequency of administration decreased. On the sixth day liquid diet practically ad libitum is given, and about the eighth day soft diet. The bowels are moved early, especially if there is much pain or any fever. Most pain after section comes from flatus. The bowels are moved, preferably by enema, or by calomel in broken doses, or by citrate of magnesia solution. As an enema the following is employed : B.-Magnesii sulph ^ij. Glycerini ^i. 01. terebinth. 5ss. Aquae q. s. ad giv.-M. This is a very satisfactory formula. The tube is attended to by myself. It is drained two or three times in twenty-four hours; oftener if the drainage is excessive, or if ABDOMINAL SURGERY. 7 bleeding is going on. Sterilized cotton is seized by the tube-forceps and passed down the tube. In this way all fluid is removed. Then a rope of gauze is passed down the tube, and the cotton and bandage reapplied. Each time before cleaning the tube the hands are scrubbed, and if septic cases are being handled, a sublimate bath is used. The tube is removed early ; usually on the second day. It is re- moved as soon as the drainage is straw-colored and does not run up the gauze into the cotton. After removing it the provisional stitch, which has been placed during the operation, is tied. The wound is now dusted with a powder containing one part of iodoform to seven of boric acid. Fresh gauze and clean cotton are now applied, and, in general, the wound is not looked at again until the seventh or eighth day, when the deep sutures are taken out and adhesive straps put on. This method of dressing I find perfectly satisfactory. I have had but one stitch-hole abcess in over a year. The catheter is not used if it is possible to avoid it. When neces- sary, a glass catheter is employed. This is taken from sublimate solution; the vestibule is dried with cotton ; the, catheter properly smeared with vaseline, is inserted ; after use it is thoroughly cleaned and put back in sublimate solution. Catheter cystitis is rare. Patients are kept on their backs for two weeks. The bed-rest is used after ten days. After two or three weeks they are allowed to get up, and are discharged, in general, after four weeks. I think it is best to keep section cases in bed three weeks. Fat women should lie fully three weeks ; they are most liable to have hernia. Treatment of Complicated Cases.-Shock is met by the use of strychnia and digitalis given hypodermically external heat and hot coffee, or hot beef-tea and whiskey given by enema. I do not like to give more than thirty minims of tincture of digitalis, nor one- eighth of a grain of sulphate of strychnia, within six hours. If shock gives way to asthenia, strychnia and digitalis are continued. In twenty-four hours one drachm of tincture of digitalis, and from | to | of a grain of strychnia, are given. For stimulation, enemas of beef-tea one pint, whiskey two ounces, are used. For rectal alimentation, the following combination is used: One egg. Milk £viii. Peptonize, and add whiskey This is given every six hours. I have not found rectal injections to relieve thirst. When fever occurs, every effort is made to move the bowels. 8 NOBLE, An enema, calomel, or magnesia citrate solution is used. I have found the stomachs of those needing purgation too irritable to retain Epsom salts or Seidlitz powders. Morphia or opium is used scarcely at all. Cases that do well do not need it. A little encouragement enables them to bear the pain for twenty-four hours, after which time it usually is not severe. In very excitable women, and in cases where pain has kept up for several days, morphia has been given sparingly. Whether this plan is the best in patients that are suffering severely I am not entirely convinced, nor that if is best to withhold morphia in all cases, but have yielded to the current of modern practice. I intend to try phenacetin, antipyrine, chloral, and the bromides for sleeplessness, in cases in which the condition of the pulse does not contra-indicate depressants. Patients requiring stimulation usually have an irritable stomach; hence whiskey is given by enema, or champagne by the mouth. Less can be done by alimentation and medication after abdominal section than after other operations, to combat asthenia; because the stomach is not available, as a rule. The fate of the patient is decided, in general, when the operation is completed. Analysis of Cases.-Of the 85 cases operated on, there were of single 5 double 6 Pyosalpinx Chronic salpingitis and ovaritis 18 (Of these, 10 were densely adherent.) Cirrhotic ovaries 5 Tubercular peritonitis: cancer of ovaries (same patient operated on five times) 5 Parovarian cysts 2 Ovarian cysts 14 11 Tubal pregnancy unruptured 2 ruptured 2 4 Retroflexion-hysterorrhaphy 4 Hydro-salpinx 4 Fibroid of uterus (1 myomectomy, with removal of one appendage; 3 removals of uterine appendages; 1 removal of one appendage) 5 Caesarean section 1 Bowel adhesions 1 Mixed cases. Ovarian tumors complicated by salpingitis 4 pyosalpinx 4 hydro-salpinx 1 haemato-salpinx 2 11 Total 85 ABDOMINAL SURGERY. 9 Of these abdominal sections, 18 were done by Dr. Kelly, 7 by Dr. Robb, and 60 by myself. There have been 7 deaths, in my own cases. Both uterine appendages* were removed in 60 cases for ovarian tumors, or the various forms of salpingitis or tubal pregnancy. One uterine appendage was removed in 13 cases-or really in 12 cases, for in one the other tube and ovary was removed subse- quently. This poor woman figures as 5 cases of tubercular perito- nitis and cancer of the ovaries. She will be mentioned later. Of the women who had but one appendage removed one has had a baby, and a second is pregnant. The first was operated on in extremis for a huge pyosalpinx and abscess of the ovary ; the other had a myo- mectomy and removal of one lightly adherent appendage. In 4 cases hysterorrhaphy was done. In 1 case the operation was to separate bowel adhesions resulting from a previous section. There was 1 case of Caesarean section ; a thoroughly unique case, which will be reported in full to the College of Physicians. There were two exploratory incisions. The first was made to determine the nature of an exudate forming after the removal of the appendages for fibroid of the uterus. It proved to be a cellulitis of the broad ligament, caused by an infected pedicle. This case and two similar cases suggest to me that many of the so-called haematomas reported by Mr. Tait are cases of infected pedicle. The other ex- ploratory incision was an incomplete operation, in the sense that I started to remove a fibroid tumor, but, finding an anomaly of the bladder, I desisted. The bladder was developed to within one inch of the umbilicus, and there was an absence of the vesico-abdominal pouch of the peritoneum; that is, the peritoneum simply covered the posterior wall of the bladder. As the bladder was three inches wide at its upper limit, it would have been necessary to make a lateral inci- sion along the outer border of the rectus muscle. To do a hyster- ectomy under such circumstances I felt to be unwise. Two operations were incomplete. The operation was made for the removal of both appendages. In the first case there was a chronic salpingitis on the right side, and a pyosalpinx and intra-peritoneal abscess on the left side. The right appendage and the left tube (pyosalpinx) were removed. The left ovary was imbedded in exu- date, and could not be felt. This patient is now the picture of blooming health, has gained thirty-five pounds, and menstruates regu- larly without pain. 10 NOBLE, The other case was one of defective development of the sexual organs ; having, in addition, hydro- and hmmato-salpinx. On opera- tion the left ovary was not removed, because it was apparently imbedded in the broad ligament near the pelvic wall. To have re- moved it would have required violence to tear it from its bed. As the operation had been prolonged, I did not think it wise to take the time necessary to control free bleeding from a ruptured ovarian artery. The woman has not menstruated-which fact shows the functional condition of the ovary. One broad-ligament cyst was removed from a woman who some years before had had the appendages removed for pyosalpinx. The exciting cause of the cyst was an infected pedicle. Two cases were simple sections for the evacuation of fluid in a case of tubercular peritonitis with cancer of the ovaries. The case last referred to deserves special notice. She had had both breasts removed and axillas cleared out some years ago for cancer. Five operations were performed for the primary and secondary growths. While my patient, there were a number of nodules about the thorax, which were quiescent. She had six abdominal sections ; one before the time covered by this report. Four times the fluid was removed, and twice in addition one uterine appendage was removed. After each operation she filled less rapidly than before. The perito- neum was everywhere studded with miliary bodies, supposed to be tubercles. The appendages wrere supposed to be tubercular, but microscopic examination demonstrated carcinoma. She died eleven days after the last section. The autopsy showed cancer of the stomach, duodenum, and liver. It was noticed at the last section that the tubercular peritonitis was undergoing a cure. The tubercles had disappeared, leaving the peritoneum thick and opaque. At the autopsy it was noted that the tubercles had disappeared in the pelvis and lower abdomen, but that in the upper abdomen they were still abundant. This fact suggests the query as to whether there is a relation between tubercle and cancer in the abdomen; and, again, were the miliary bodies really tubercular? Vomiting had been constant for nearly two months before the last operation. No pain was complained of, and the vomit was not bloody. It was attributed to the presence of the accumulating fluid. After operation the vomiting continued, everything being rejected. Death occurred from exhaustion on the eleventh day. This death is not included in the seven as a death from abdominal section, as the operation had nothing to do with it. ABDOMINAL SURGERY. 11 Deaths.-Three deaths occurred from suppression of urine. In one case albumin was found in the urine, and chloroform was given. Death after two days. This woman was a "wreck." She had adhe- rent appendages and an intra-ligamentous ovarian tumor adherent to the right ureter. The ureter was dissected away from the tumor and dropped. Operation was difficult. Autopsy showed right surgical kidney and left contracted kidney; no peritonitis. In the second case no albumin was found in the urine. Ether was given. Operation: Difficult enucleation of appendages imbedded in exudate. Death resulted on the fifth day from uraemia. Autopsy showed contracted kidneys; no peritonitis. This woman figured in the news- papers as having escaped from the hospital in her gown while delirious. In jumping from a low second-story window she fractured her olecranon, but otherwise I was unable to find any injury. She had been sick many years. The third case was a " wreck," having been an invalid several years. No albumin was found in the urine. Ether was given. An ovarian and a parovarian tumor were removed; rapid, simple operation. Death after three days from uraemia. Autopsy showed contracted kidneys; no peritonitis. These cases taught me the necessity of having the urine examined microscopically-even repeatedly in the cases having arterio-capillary fibrosis. With the knowledge of the kidney disease I would not operate now on such cases as the first and second. Women with con- tracted kidneys will not stand difficult operations. In such a case as the third I would try in every way to improve nutrition and to assist the kidneys, and then operate under chloroform. One death occurred on the third day from intestinal obstruction. At the autopsy it was found that an organic stricture of the colon existed, which had resulted from a long-standing adhesion of the colon to the broad ligament. Two deaths occurred from peritonitis-one on the fifth day from septic peritonitis, after the removal of double hydro-salpinx. The drainage-tube was used, but it did not empty the pelvis. This death is the only one after operation in my experience in which death would not have occurred without operation. The other occurred on the second day after the removal of double pyosalpinx and a right ovarian tumor. Free irrigation and drainage. Peritonitis developed the first day. The abdomen was again opened and flushed. Death within forty-eight hours. These are the only deaths which have occurred in my practice, except after the gravest 12 NOBLE, operations, or when the patients have been extremely prostrated by acute or chronic disease. Both of these women were feeble. One death occurred thirty-six hours after operation for ruptured tubal pregnancy. The abdomen was full of blood. Fever shortly developed, and the patient died within thirty-six hours in hyper- pyrexia. This death was attributed to sepsis, but I do not feel clear as to its cause. It was more probably due to acute anaemia. Results.-After all, the important question is, What good was accomplished by these operations ? It is gratifying to be able to say that the results have been good. I do not know a single patient who is not distinctly better than before operation. Because of the fact that all these patients are not under under my care at present it is not possible to give the exact percentage of those cured, improved, etc. Many become immediately and permanently cured after con- valescence from the operation. More are improved after operation, and their cure is delayed six or more months. Some will never be well women, although the operation accomplished all that was ex- pected. The menopause with its nervous manifestations annoys some patients, but in none have serious symptoms been found. Finally, those patients became well quickly who were operated on early, before the general health and nutrition were impaired. The operation removed all disease. Depending upon the chronicity of the disease and the local complications, and upon the impairment of the general health, the restoration to health has been rapid or slow. The " wrecks " have improved, but none of them are robust women. The question of prompt, early operation for grave pelvic disease is now the most important one in gynecology, and results can only improve when the profession becomes convinced of this fact, and women are sent to the gynecologist while it is yet possible to cure them.1 1 The technique employed is based on that introduced by Dr. Kelly. I am under many obligations to him, and to Drs. Robb and Boyd, for advice and assistance. ABDOMINAL SURGERY. 13 No. Name, and date of operation. Age Disease. Operation. Drainage Result. Operator. 1 Mrs. McG., Jane 8,1889 30 Pyosalpinx. Abdominal sec- tion ; removal of uterine append- ages. 1^ days Recovered. Dr. H. A. Kelly. 2 Mrs. H., June 24 27 Double pyosal- pinx. Removal of uterine appendages. 36 hours Recovered. Dr. H. Robb. 3 Mrs. S., July 5 18 Large cirrhotic ovaries. Removal of uterine appendages. 10 hours Recovered. Dr. H. Robb. 4 Miss E., July 24 23 Double pyosal- pinx. Removal of uterine appendages. 2% days Recovered. Dr. H Robb. 5 Mrs. N., July 29 23 Salpingitis and ovaritis. Removal of uterine appendages. None Recovered. Dr. H. Robb. 6 Mrs. 0., July 31 40 Tuberculous peri- tonitis. Abdominal section. 12 hours Recovered. Dr. H. Robb. 7 Mrs. K., Aug. 5 30 Salpingitis and ovaritis. Removal of uterine appendages. 12 hours Recovered. Dr. H. Robb. 8 Mrs. J., Aug. 14 31 Cirrhotic ovaries. Removal of uterine appendages. None Recovered. Dr. H. Robb. 9 Mrs. X., Aug. 19 36 left, pyosalpinx; right,salpingitis. Removal of uterine appendages. 48 hours Recovered. (Stitch-hole abscess.) Dr. C. P. Noble. 10 Mrs. J., Aug. 22 20 Double salpin- gitis ; cheesy tubes; dense adhesions. Removal of uterine appendages. 24 hours Recovered. (Sinus.) Dr. C. P. froble. 11 Mrs. P., Sept. 10 30 Pyosalpinx, double. Removal of uterine appendages. Yes Recovered. Dr. H. A. Kelly. 12 Mrs. W., Sept. 12 31 Parovarian. Removal of one appendage. None Recovered. Dr. H. A. Kelly. 13 Mrs. G., Sept. 23 27 Left tubal preg- nancy ; right ovarian cyst. Removal of ap- pendages. 48 hours Recovered. Dr. C. P. Noble. 14 Mrs. S.( Sept. 26 39 Ovarian cyst. Removal of ap- pendages. 36 hours Recovered. Dr. C. P. Noble. 15 Mrs. B., Oct. 14, 26 Ovaritis; varico- cele of broad ligament. Removal of ap- pendages. None Recovered Dr. C. P. Noble. 16 Mrs. M., Oct. 19 43 Retroflexion. Hysterorrhaphy. None Recovered. Dr. H. A. Kelly. 17 Mrs. C., Oct. 24 40 Pyosalpinx; intra-peritoneal abscess. Removal of ap- pendages. 33 hours Recovered. (Sinus.) Dr. C. P. Noble. 18 Mrs. L., Oct. 26 30 Gonorrhoeal sal- pingitis. Removal of ap- pendages. 29 hours Recovered. Dr. C. P. Noble. 19 Mrs H., Nov. 30 33 Hydrosalpinx. Removal of ap- pendages. 3 days Recovered. Dr. H. A. Kelly. 20 Mrs. P-., Jan. 3, 1890 23 Pyosalpinx and abscess of ovary. Removal of one uterine appendage. 48 hours Recovered. Dr. 0. P. Noble. 21 Mrs. 0., Jan. 4 28 Ovarian tumor. Removal of uterine appendages. 48 hours Recovered. Dr. H. A. Kelly; 22 Mrs. 0., Jan. 28 35 Fibroid of uterus. Removal of left uterine appendage; right, inaccessible. 48 hours Recovered. Dr. C. P. Noble. 23 Mrs. J., Jan. 30 29 Double pyosal- pinx ; abscess of left ovary. Removal of both appendages; % pint of pus. 72 hours Recovered. Dr. C. P. Noble. 24 Miss 0., Feb. 1 22 Retroflexion. Hysterorrhaphy. 48 hours Recovered. Dr. H. A. Kelly. 25 Mrs. S., Feb. 1 28 Ovarian tumor on right side; cystic ovary on left. Removal of uterine appendages. 5 days Recovered. Dr. H. A. Kelly. 26 Mrs. 0., Feb. 4 28 Salpingitis and cystic ovaries. Removal of ap- pendages. 16 days Hemor- rhage. Recovered. Dr. C. P. Noble. 27 Miss B., Feb. 8 19 Dermoid cyst of left ovary. Removal of left appendage; very dense adhesions. 22 days Recovered.1 Dr. C. P. Noble. 28 Mrs. Y., Feb. 27 40 Ovarian tumor on right side; sal- pingitis on left. Removal of tumor and appendage on left side. 58 hours Recovered. Dr. C. P. Noble. 29 Mrs. S., March 1 32 Salpingitis, double. Removal of uterine appendages. 48 hours Recovered. Dr. H. A. Kelly. 1 Fecal fistula discovered after 48 hours. After third week fecal fistula closed, and after eight weeks sinus entirely closed up. 14 NOBLE, No. Name, and date of operation. Age Disease. Operation. Drainage Result. Operator. 30 Mrs. R., March 7 29 Right, intraliga- mentary ovarian cyst adherent to ureter; left,tube and ovary ad- herent ; chronic nephritis. Removal of uterine appendages ; chloroform. Yes Death 3d day. Sup- pression of urine after 24 hours. Post-mort. Dr. C. P. Noble. 31 Mrs. Z., March 13 31 Double hydrosal- pinx, size of orange, on right side. Removal of uterine appendages. Yes Death third day from intestinal obstruction coming on after 24 hrs. Organic stricture of colon. Post-mort. Dr. C. P. Noble. 32 Mrs. MeV., March 15 42 Retroflexion of uterus. Hysterorrhaphy. None Recovered. Dr. H. A. Kelly. 33 * Mrs. N., ■March 20 28 Unruptured tubal pregnancy on right side ; sal- pingitis on left. Removal of preg- nant tube and ovary, also left appendage. 48 hours Recovered. Dr. C. P. Noble. 34 Miss V., March 29 21 Ovarian cyst on right side. Removal of right uterine appendage 48 hours Recovered. Dr. H. A. Kelly. 35 Mrs. X., April 3 24 Cystic degenera- tion of ovaries; double salpin- gitis. Removal of uterine appendages. 50 hours Recovered. Dr. C. P. Noble. 36 Mrs. 0., April 5 40 Tuberculosis peri- tonei ; cancer of ovaries. Evacuation of fluid and removal of left uterine ap- pendage. 48 hours Recovered. Dr. H. A. Kelly. 37 Miss R., April 7 23 Gonorrhoeal sal- pingitis. Removal of uterine appendages. 36 hours Recovered. Dr. C. P. Noble. 38 Mrs. X., April 12 30 Salpingitis with extensive adhe- Removal of uterine appendages. 77 hours Recovered. Dr. C. P. Noble. 39 Mrs. McC., April 12 sions. Myoma uteri. Myomectomy; re- moval of right ovary and tube Yes Recovered. Dr. H. A. Kelly. 40 Miss C., April 12 30 Large cystic ova- ries ; menstrual epilepsy. Removal of uterine appendages. 48 hours Recovered. Dr. H. A. Kelly. 41 Mrs. J., April 15 44 Fibroid of uterus and double sal- pingitis. Removal of uterine appendages. 50 hours Recovered. Dr. C. P. Noble. 42 Mrs. R., April 15 33 Salpingitis with adhesions. Removal of ap- pendages ; right tube rudiment- ary with ovary separated from pelvis and at- tached to omen- tum. 67 hours Recovered. Dr. C. P. Noble. 43 Mrs. W., April 19 39 Intraligamentous cyst right side. Removal of cyst. 48 hours Recovered. Dr. H. A. Kelly. 44 Miss J., April 19 23 Double ovarian tumor. Removal of tumors; pedicle to right tumor very fleshy. 72 hours Recovered. Hemorrhage -reopened belly next day and flushed ; sutured broad liga- ment. Dr. C. P. Noble. 45 Mrs. R., April 22 27 Small ovarian cyst. Removal of uterine appendages. 48 hours Recovered. Dr. C. P. Noble. 46 Mrs. B., April 22 20 Double salpin- gitis, with ova- rian cyst on left side. Removal of uterine appendages. 78 hours Recovered. Ether pneu- monia. Dr. C. P. Noble. ABDOMINAL SURGERY. 15 No. Name, and date of operation. Age Disease. Operation. Drainage Result. Operator. 47 Mrs. R., April 26 29 Dense adhesion of small intestines and rectum to pedicle of left tube and ovary resulting from operation one year ago. Adhesions broken up. 55 hours Recovered. Dr. C. P. Noble. 48 Mrs. J., April 27 28 Pregnancy com- plicated by con- tracted pelvis. Caesarean section. None Recovered. Dr. C. P. Noble. 49 Miss X., May 3 22 Ovaritis; large left ovary. Removal of left uterine append- age. 43 hours Recovered. Dr. C. P. Noble. 50 Mrs. M., May 7 34 Specific tubo-ova- rian inflamma- tion. Ether: removal of both tubes and ovaries with dif- ficulty. 42 hours Death from uraemic poisoning. Post-mort.: chronic nephritis. Dr. C. P. Noble. 51 Mrs. K.( May 10 37 Double ovarian cyst. Tumors removed; 4 gals, pus eva- cuated from right cyst; ligated fleshy pedicle 7 or 8 inches wide 30 hours Recovered. Dr C. P. Noble. 52 Mrs. C., May 13 35 Double hydrosal- pinx, with ad- hesions. Removal of uterine appendages. Yes Death from septic perito- nitis on fifth day. Recovered. Dr. C. P. Noble. 53 Mrs. A., May 31 54 Ruptured colloid cyst of right ovary. Removal of cyst and free colloid material in peri- toneum. 2 weeks Dr. C. P. Noble. 54 Mrs. A., June 2 40 Extra-uterine pregnancy. Ruptured tube. Belly filled with fluid and clotted blood to diaph- ragm ; append- age tied off. Yes Death from acute sepsis within 36 hours? hy- perpyrexia ; no other symptom. Dr. C. P. Noble. 55 Mrs. L., June 4 22 Right ovarian cyst; double pyosalpinx. Removal of uterine appendages. Yes Belly re- opened and flushed. Death from acute septic peritonitis. Dr. C. P. Noble. 56 Mrs. B., June 11 27 Double salpin- gitis. Removal of uterine appendages 65 hours Recovered. Dr. C. P. Noble. 57 Mrs. T., June 19 Salpingitis and extensive adhe- sions. Removal of uterine appendages. 10 days Slight hemor- rhage. Recovered. Dr. C. P. Noble. 58 Mrs. W., Sept. 4 40 Ovarian tumor on right side; par- ovarian on left side. Removal of uterine appendages; ether. Yes Death from uraemia on third day. Post-mort.: contracted kidneys. Dr. C. P. Noble. 59 Mrs. S., Sept. 4 30 Parovarian cyst on left side. Removal of cyst. 72 hours Recovered. Dr. C. P. Noble. 60 Mrs. B., Sept. 6 34 Pyosalpinx with ovarian cyst on right side ; left salpingitis. Removal of ap- pendages. 10 days Recovered. Belly re- opened for peritonitis; flushed. Dr. 0. P. Noble. 61 Mrs. M., Sept. 13 58 Intra-ligamentous ovarian cyst on left side. Removal of cyst containing 8 qts. of fluid material. 40 hours Recovered. Dr. C. P. Noble. 62 Miss W., Oct 15 30 Fibroid tumor. Removal of ap- pendages. 2 days Recovered. Dr. C. P. Noble. 63 Mrs. Y., Oct. 15 26 Small ovarian tu- mor and large hydrosalpinx on .right side; hae- mato-salpinx on left. Removal of ap- pendages ; left ovary not re- moved. 4 days Recovered. Dr. 0. P. Noble. 16 ABDOMINAL SURGERY. No. Name, and date of operation. Age Disease. Operation. Drainage Result. Operator. 64 Mrs. X., Oct. 18 27 Double pyosal- pinx; ovarian tumor on right side. Removal of tumor and appendages. 4 days 2 tubes. Recovered. Dr. C. P. Noble. 65 Mrs. W., Nov. 5 42 Chronic invalid- ism ; adherent cirrhotic ovaries. Removal of appen- dages. 5 days Recovered. Dr. C. P. Noble. 66 Miss W., Nov. 8 30 Cellulitis right broad ligament. Exploratory in- cision. Yes Recovered. Dr. C. P. Noble. 67 Mrs. P., Nov. 19 24 Cheesy tubes with cystic ovaries. Removal of uterine appendages. 2 days Recovered. Dr. C. P. Noble. 68 Miss 0., Nov. 23 23 Dysmenorrhoea; constant pelvic pain; cystic and cirrhotic ovaries; neurasthenia. Removal of uterine appendages. 2 days Recovered. Dr. C. P. Noble. 69 Mrs. X., Dec. 10 30 Double pyosal- pinx. Removal of uterine appendages. 4 days Recovered. Ether bron- chitis. Dr. C. P. Noble. 70 Mrs. J., Dec. 17 24 Ovarian cyst and hsemato-salpinx on left side. Removal of left uterine append- age. 2 days Recovered. Dr. C. P. Noble. 71 Mrs. 0., Jan. 10,1891 37 Double salpin- gitis; unruptur- ed tubal preg- nancy on left side. Removal of uterine appendages. 32 hours Recovered. Dr. 0. P. Noble. 72 Mrs. A., Jan. 17 41 Cystic ovaries and chronic salpin- gitis. Removal of uterine appendages. 4 weeks Hemor- rhage. Recovered. Dr. C. P. Noble. 73 Mrs. H., Jan. 17 38 Ovarian cyst on left side ; fibroid of uterus; mens- trual insanity. Removal of uterine appendages. 2 days Recovered. Dr. C. P. Noble. 74 Mrs. Y ., Jan. 22 28 Chronic salpin- gitis and ova- ritis ; very dense adhesions. Removal of uterine appendages. 2% days Recovered. Dr. C. P. Noble. 75 Mrs. 0., Jan. 28 42 Tubercular peri- tonitis and can- cer of stomach. Evacuation of fluid. 80 hours Recovered.1 Dr. 0. P. Noble. 76 Mrs. M., Feb. 5 26 Pyosalpinx on right side ; sal- pingitis on left. Removal of uterine appendages. 2 days Recovered. Dr. C. P. Noble. 77 Mrs. P., March 11 33 Ovarian tumor on right side; sal- pingitis on left. Removal of uterine appendages. 2 days Recovered. Dr. C. P. Noble. 78 Mrs. H., March 11 33 Retroflexion; ad- herent append- Removal of uterine appendages 5 days Recovered. Dr. 0. P. Noble. 79 Mrs. K , March 16 38 S • Double hydrosal- pinx. Removal of ap- pendages. 4 days Recovered. Dr. C. P. Noble. 80 Mrs. A., March 16 36 Double hydrosal- pinx. Removal of uterine appendages. 2 days Recovered. Dr. C. P. Noble. 81 Miss T., March 23 17 Fibroid of uterus. Exploratory sec- tion. None Recovered. Dr. C. P. Noble. 82 Miss S., March 23 34 Rudimentary ap- pendages ; neur- asthenia. Removal of uterine appendages. 2 days Recovered. Dr. C. P..Noble. 83 Mrs. N., Sept.27, 1890 34 Ovarian cystoma on left side. Removal of one appendage. 12 hours Recovered. Dr. H. A..Kelly. 84 Mrs. 0 , Sept. 27 40 Tuberculous peri- tonitis. Removal of right uterine append- Yes Recovered. Dr. H. A. Kelly. 85 Mrs. M., Sept. 28 30 Right, ovarian cystoma; left, adherent ovary and tube. age. . Removal of uterine appendages. Yes Recovered. Dr. H. A. Kelly. 1 Death from exhaustion on the 11th day caused by constant vomiting excited by cancer of stomach. Had been vomiting for two months. Post-mortem.