($■ CdsTof (Refentfts (ptgmenfoera triaitb (Bfecfricaffp. A CASE OF RETINITIS PIGMENTOSA TREATED ELECTRICALLY. BY MYLES STANDISH, M.D. ' Ophthalmic Surgeon to Out-patients Carney Hospital, Assistant Ophthalmic Surgeon Boston City Hospital, Instructor in Ophthalmology Boston Policlinic, etc. BOSTON: DAVID CLAPP & SON, PRINTERS. X5 Reprinted from Transactions of American Ophthalmological Society, 1887. A CASE OF RETINITIS PIGMENTOSA TREATED ELECTRICALLY. I am well aware that to report the result of the treatment of a single case of any disease and to draw deductions there- from as to the efficacy of the method of treatment is a rash proceeding, and I would not occupy the time of the Society by reporting this case except for the fact that it is one of several cases reported at the last meeting of this Society by Dr. Hasket Derby, in a paper which excited considerable discussion at that time. The patient was a woman thirty-three years of age. She had myopia of 1.50 diopters in each eye, and had worn cor- recting lenses since she was seventeen years old. Her parents were not relatives. She was the only child of her father's first marriage, and had several half brothers and sisters who have never had any trouble with their eyes. Several members of her mother's family were "near-sighted." When first seen by me on the 14th of April, 1886, she had noticed an increasing failure of vision for the previous three years, which had increased very rapidly in the three months previous to her visit to me. Her night-blindness had recently become so great that she could no longer go on the street after night-fall with safety. The ophthalmoscope showed a 4 considerable number of the characteristic star-shaped spots of retinitis pigmentosa in the periphery of the fundus in each eye. Her vision was, right ; left The field of vision did not extend over 20° in any meridian in either eye, as will be seen in the accompanying diagram. --- Fmo Hn. M. The only treatment employed in this case was the contin- uous electrical current. The positive pole was placed upon the closed eye-lid and the negative pole on the brow or temple. The strength of the current used was only such as could be comfortably borne, and has generally been derived from not more than four or six cells of a Stohrer's battery. The current has been passed in this manner for five minutes at a time, at intervals of several days. For the last ten months there has been a uniform interval of five days between the sittings. The patient has not been restricted in the use of her eyes while under treatment, and has used them constantly for fine work. 5 For the fifteen months that she has been under treatment there has been a steady improvement both in central and eccentric vision from the commencement up to the present time, except as hereinafter stated. These exceptions are, first, that there has been no improvement of vision for the last three months, although under treatment during that period; and, second, that in the summer of 1886, after the patient had been under treatment for four months, she went out of the city on a vacation, and was absent for six weeks, during which period the electricity was omitted, and upon her return it was found that her vision had fallen somewhat, both centrally and eccentrically, but .the loss did not exceed a quarter of what she had previously gained. Her present vision is, right ; left The present horizontal diameters of the fields of vision, as will be seen by the diagrams, are, right 750; left 70°; and the vertical diameters are, right 70°; left 68°. This rather startling result has been verified by repeated examinations. The fields of vision have been taken with great care in the earlier, as well as the later periods of obser- vation ; upon a perimeter, at noon, on a clear day, with the perimeter facing the light, and at the same distance from the window at each trial. The objects used in determining the areas of the fields have been pieces of white paper, one centi- metre square. On testing central vision the test types have been changed from time to time to avoid the danger of making too high a record by the use of familiar letters. Some ophthalmoscopic changes have taken place while the patient has been under treatment; but these changes have been confined to a widening out of the prolongations of each patch of pigment, so that they do not now present such char- 6 acteristic bone-corpuscle-like shapes as they did when first seen. No new patches of pigment have appeared. To argue from this case that all or even a very considerable number of cases of retinitis pigmentosa would be similarly benefited by the use of electricity would be manifestly absurd ; but that such an improvement in central and eccen- tric vision should happen to any case of retinitis pigmentosa, either with or without treatment, is a noteworthy fact, and one that should draw our attention to the circumstances of that particular case. We have present in this case, besides the constant treatment during a period of fifteen months, several other peculiarities. It came on fully as late in life as this disease ever develops, that is, if we may believe the patient's statements, at about thirty years of age, but did not progress very rapidly until the last three months before she came under observation, during which period, however, the onset of the disease was unusually rapid. Again, when first seen, the impairment of vision was very much greater than we should be led to expect by an ex- amination of the fundus, from which it would appear that treatment was begun while the disease was yet in its active stage, preceding the visible deposition of pigment in the retina. From these considerations it would seem, in so far as one case is capable of teaching anything, that when a case of retinitis pigmentosa is seen in its earliest stages, or when there is a sudden exacerbation of the disease, as evidenced by diminution of the functions of the eyes, a trial of galvanism should be made.