REPRESSION OF MENSTRUATION AS A CURATIVE AGENT IN GYNECOLOGY. BY EUGENE 0. GEHRUNG, M.D., St. Louis. [Reprinted from the American Journal of Obstetrics and Diseases of Women and Children, Vol. XXI., November, 1888.] N E W Y 0 R K: WILLIAM WOOD & COMPANY, PUBLISHERS, 56 & 58 Lafayette Place. 1888. REPRESSION OF MENSTRUATION ZS A CURATIVE AGENT IN GYNECOLOGY. BY EUGENE C. GEHRUNG, M.D., St. Louis. [Reprinted from the American Journal of Obstetrics and Diseases of Women and Children, Vol. XXI., November, 1888.] NEW YORK: WILLIAM WOOD & COMPANY, PUBLISHERS, 56 & 58 Lafayette Place. 1888. REPRESSION OF MENSTRUATION AS A CURATIVE AGENT IN GYNECOLOGY.1 Menstruation is a periodical, usually sanguineous flow of variable quantity and duration, to which most women are sub- ject for a shorter or longer period of their lives. This short definition of menstruation shows at a glance the great uncertainty surrounding every phase of this process. In fact a search through literature on this subject shows as many different opinions as there are authorities consulted. A certain degree of order may, however, be brought into this chaos, suffi- cient for our present purpose, and without the necessity of quoting the different opinions at length, by choosing the outside limits of the various estimates, which will read as follows: Menstruation returns every twenty to thirty-one days; lasts from two to eight or ten days, causing a loss of blood of from two ounces or less to eighteen ounces or more. To encompass the irregularities of menstruation, a still greater latitude must be allowed, as the following quotations will show : " The fluid is not in all cases sanguineous; indeed, its bloody character may be regarded as accidental, though present in the infinite majority of cases.2 . . . "Another observation of great interest has been alluded to by Dr. James Stirton3 to the effect that in certain barbarous tribes of South Africa, whose habits of life closely approach 1 Presented to the American Gynecological Society, Sept., 1888. 2 Diction, of Medicine, Quain. 8 Glasgow Medical Journal and Annal. Univ. Med. Science. 4 Gehrung : Repression of Menstruation those of the brute creation, the women menstruate only at ir- regular periods and in a very scanty manner. And further, that menstruation itself is slowly inaugurated with a discharge of mucus, as in the case of what may be termed the menstruation of the inferior animals. In these women it is said that nothing like normal menstruation takes place until after indiscriminate intercourse has been practised. " Dr. Stirton believes that menstruation is a product of civili- zation, supporting his theory by facts drawn from a study of comparative physiology. . . . Complete suppression of the menses is alleged to take place very frequently among the women of Greenland, especially during the winter season, and that, too, without entailing the slightest disturbances of health. Similar conditions are said to prevail among the inhabitants of the higher mountainous regions'of Switzerland and France." There has been no lack of observation of the phenomena of menstruation, and these have led to a tolerably fair understand- ing of this process as it occurs at present, though little or nothing is definitely known as to Nature's original intentions. The mechanism of menstruation, considered in the light of this essay, is as follows : From some yet unknown or insufficiently known cause a gradual retention of blood in the venous plexuses of the pelvis takes place, causing a hyperemia or engorgement of all the pel- vic organs and tissues. The blood for this purpose is withdrawn from the general circulation, producing lassitude, malaise, etc., while in the pelvis heaviness or fulness, so generally complained of, is produced, constituting what is called the menstrual mo- limina. Only a slight discharge is necessary, usually from the endometrium, to relieve the over-tension, when the balance returns to the general circulation from whence it came. It is not the amount of blood in the body which conditions the amount of engorgement, nor is it the amount of engorge- ment that determines the amount of the flow ; it is the complete or incomplete balance between the engorgement and the resist- ance to it, whereby the amount of the flow is regulated. The engorgement itself is regulated, and stands in direct relation to the tonicity or atonicity of the respective nerves and muscles. The resistance consists in the amount of obstruction placed in the way of the flow, especially the contractile power of the uterus. as a Curative Agent. 5 If the degree of engorgement and the opposed resistance are equally balanced, there will be little or no sanguineous flow ; if the engorgement predominates over the resistance, the flow will be correspondingly profuse ; on the other hand, if the engorge- ment be feeble, and the resistance marked, there will be little loss, if any. Again, a slight engorgement opposed by little or no resistance will result in a considerable flow, while a pro- nounced engorgement meeting with a strong resistance may be followed by scarcely any flow. There are many degrees and variations between these extremes. From what has been said, it is not difficult to see that in weak and nervous women, on account of the imperfect innervation, the engorgement should run high in proportion to the amount of blood in the system, and, on account of the weak musculature, the resistance would be small and, in due proportion, the flow great, while in a strong and healthy woman, from opposite con- ditions, the flow would be small. The engorgement having subserved its purpose, the blood that has not been wasted will slowly return into the general circulation. How much was Nature's intention to be wasted in this process ? My answer is: Little in the strong and healthy; little or none in the weak and anemic. The menstrual flow with women of the present day is greatly in excess of the actual want, even though it be confined entirely within the so-called physiological limits, because of the increas- ing engorgement and the decreasing resistance in consequence of the depressive influences of civilization, the effects of the constant repetition of menstruation, the effects of pregnancy and labor, and finally from the transmitted habit by inherit- ance. Strong and robust women stand the loss of great quantities apparently well during a long period of their menstrual life, yet the final result is that their constitution is undermined, and, despite their healthy appearance, their vital power is sapped, and on closer investigation it will be found that that appearance of health-plethora, corpulence, etc.-is nothing more than a mask for the underlying group of symptoms denoting anemia. If the great losses are tolerated badly even by strong and apparently healthy women, if this waste leads even with them to constitutional depravation, how much more must this be the 6 Geiirung : Repression of Menst/rnation case with the nervous, weak, and anemic women. These having- a far greater propensity to excessive bleeding, because of their weakness and impoverished blood, favoring a greater degree of engorgement, accompanied with diminished resistance. Some of the evils consequent of this uncalled-for waste are: Neuralgia, neurasthenia, melancholia, anemia with all its neu- roses and circulatory disturbances; chlorosis (?); uterine dis- eases, such as flexions and versions, vegetations and even in- flammations, diseases of the uterine appendages, etc. AU of these troubles may prove incurable without removal of the cause. Every practitioner will recall a number of those pitiful cases of broken-down constitution, nervous to the verge of insanity, complaining of all ills flesh is heir to, who under appropriate treatment improve for a while until the next return of the menses mercilessly destroys all that has been gained. The woman's whole existence is spent in making blood enough to be again uselessly spilled at the next menstrual period, while the physician is driven to despair of an ultimate success. Ton- ics, hemostatics, styptics, diet, travel, hydrotherapeutics, rest, etc., are prescribed heroically, and the result is usually disap- pointment. The poor, thus afflicted woman passes from the hands of a neurologist into those of a gynecologist, and again from the lat- ter to the former, until exhausted in confidence, blood, and means. Each in his turn has honestly done the best in his power ; all that teachers and books have taught him. All are more or less conscious that each recurring menstruation destroys again the fruits of their labor. Yet, who has the courage to interfere with that almost sanctified function (?), menstruation 1 The physician is convinced that his patient should not lose blood, in fact that she cannot afford to lose any, but that inex- orable menstruation, that noli me tangere, will exact a certain amount of this vital fluid, while the physician is Pegging nature to relent, by means of the routine treatment, where indeed, if he possesses the courage to destroy this idol, he can corn/mand by the tampon. Yes, the tampon is the remedy (assisted or not by other means, as may be desired) which stands at the disposition of every practitioner, whereby he may regulate the amount of loss in menstruation, according to the necessity of the case, to the best as a Owrati/ve Agent. 7 of his judgment. However little the amount lost in a given case may be, it may be far greater than is admissible for the welfare of the individual under consideration, and it should be lessened or arrested without fear. The blood thrown into the pelvic reservoir, constituting the menstrual engorgement, is certainly not intended to be cast off in toto. If the engorge- ment is great, only a small amount is destined to flow away to relieve the over-distention until the determination to the pelvis is past, when the blood may safely return to the general circula- tion. Since it is not bad blood, as has formerly been imagined,, but the same as is used in the balance of the economy, the quantity so reserved is fully as useful as a similar cpiantity gained by the use of tonics or transfusion. These are not theories, but facts, well proven by the results of my practice, covering a space of nearly two years, and gained from a great number of cases. Despite the great reluctance of gynecologists of even the present day to interfere with a menstruating woman, it will not be long ere, in appropriate cases, the time of the catamenia will be selected for gynecological treatment, in preference to the intermenstrual period. The amount of blood thus saved not only lessens the anemia with its sequelae, but diminishes the tendency to waste in the future, by lessening the tendency to transudation on account of the improved quality of the blood, and by increasing the resist- ance in consequence of improved tonicity of the uterus, etc., and by destroying the habit of great losses. In cases of delayed menopause from the habit of excessive engorgements and losses, this termination of the great menstrual cycle may be enhanced, to the great advantage of the patient, in whom the continuance might have been a source for the de- velopment of tumors, cancer, etc. Besides these immediate benefits of repressed menstruation, the direct benefits of the tampon are gained at a time when the tis- sues are in the best condition to receive them. The pressure, support, and medication of the tampon will frequently bring about results which have been sought in vain to be obtained at other times and by other means. In opposition to this treatment, the bad results of amenor- rhea, suppression of menstruation, etc., may be mentioned, but these are the results and not the causes of some local or general 8 Gehrung : Repression of Menstruation diseases, and besides this treatment is not intended to be a sup- pression, but merely a repression of menstruation, in appropri- ate cases. The tampon is preferably made of absorbent cotton ; that made by Johnson & Johnson, for the use of surgeons and den- tists, consisting of a thin, endless layer, is the most convenient to handle. This may either be made in little balls of the size of a pecan to that of a walnut, or torn lengthwise in two to four slips of twelve to twenty-four inches in length. These being squeezed dry from a solution of 1-100 to 2-100 alum and water are packed, the former in lumps, the latter in strips around and upon the cervix secundum artem, until the vagina is filled. Either a Sims' speculum or a bi- or tri-valve specu- lum may be used. I prefer a short bivalve speculum for ordi- nary cases, and for virgins a small trivalve, which I had expressly constructed for that class of cases, and which can be used without stretching the hymen. To make the tampon solid, I use two pairs of uterine dressing forceps, the one to press the tampon in the opposite direction from where I intend to make the next application by the other. In this manner a very effi- cient tampon can be applied, without much inconvenience to the patient or the physician. When complete, the tampon can be fixed by the two points of an open pair of forceps, while the speculum is withdrawn. Of course variations may be made in the kind of speculum used, the medication of the cotton, and manipulation in placing the tampon to suit the operator. The tampon is then left untouched for forty-eight hours, unless the bleeding should recur sooner, when it should immediately be applied fresh. This does not only lessen or stop the bleeding, but also the duration of menstruation; as a person habitually bleeding for eight or ten days may be entirely through in two or three days. Nothing should be introduced into the cervix or uterine cavity. During this treatment rest is desirable, though not absolutely necessary. When should the tampon be applied 't I give the patient directions to call at my office or send for me on the first sign of the coming menstruation. I find that even with this precaution, as much or more blood is usually lost before the tampon is applied than is necessary or desirable; if not, the latter may be applied more or less loosely, so that a sufficient quantity can soak into the tampon. as a Curative Agent. 9 If a tampon lias been used during the full time of the usual duration of menstruation in a given case, and if, after the bleeding had ceased, it recommences again, one may almost be sure to find intra-uterine vegetations, tumors, or other compli- cations that may have formerly been overlooked, as the cause. My first attempts were of course made hesitatingly, and al- most unconsciously, because I was held in abeyance by the same dread which everybody else possesses, that any inter- ference with menstruation is fraught with danger. Who has not, at times, studied with anxiety a sanguineous flow from the uterus, for the purpose of distinguishing whether it be a hemorrhage or menstruation, to enable him to treat the same correctly, that is, to arrest a hemorrhage or to let the menstrual flow alone. At times, this distinction is not easy, if at all pos- sible, but the differential diagnosis is not so important, since both will come under the same treatment. There are certainly exceptions to this rule, as for instance when there is hemorrhage from a possibly pregnant womb, etc. " I would not touch a woman during menstruation with a forty-rod pole," is the warning ejaculation of a prominent gynecologist of this city, and the majority of the profession doubtlessly sympathize with him on this subject. The laity is possessed of still greater awe for the mysteries of menstrua- tion. At times it is not an easy task to overcome the super- stitious fear of a woman so as to gain her confidence and per- mission to interfere with her menstruation. It is, however, gratifying to see with what facility the better class of women will recognize the soundness of the practice when explained to them. With the lower classes, the less reasoning the better. One of my first cases was that of a plethoric and well-de- veloped lady, set. 48 years, widow of a physician, who had been menstruating profusely.for eight to ten days at each period all her menstrual lifetime, but is still the picture of health. For several years she suffered from occasional hemorrhages, caused by vegetations on the endometrium, for which I curetted the uterus several times with temporary benefit, as the vegetations were constantly reforming, apparently on account of the great relaxation of the entire uterus. These attacks became rather more and more frequent and it appeared as if a malignant degeneration had set in, as even curetting ceased to give lasting 10 Geiirung : Repression of Menstruation relief. After a hemorrhage that lasted from one menstrual period to nearly the next, only controlled by the vaginal tam- pon (intra-uterine tamponing made matters worse, as the uterus relaxed so completely that the blood would find its way around the ping, no matter how tightly packed), the cessation of the flow was finally accomplished. The patient, instead of being gratified with the result, ex pressed her displeasure in the following words: " Doctor, what is to become of me ? I am completely discouraged. Now we have succeeded in stopping the hemorrhage and in two days from now, my menstruation is to come on again, with a good prospect for another month's bleeding." I said to myself and to the patient that it could not be possible that, after a hemor- rhage of nearly four weeks, there can be any need for more loss of blood, though it may come under the pretense of men- struation. So I gave directions to inform me of the first symp- tom of the expected flow, to enable me to use the tampon from the very outset, so as not to lose one drop of blood if it could be prevented. This appeared quite rational to the patient, but soon superstition gained the upper hand and she raised all possible objections against such a proceeding. These were reasoned away one by one and finally I succeeded in getting her consent and promise to send for me in due time. The tampon permitted but an insignificant loss and the lady felt stronger than after any menstruation for many years past, besides she began to recover rapidly from other complications which before had resisted all treatment directed against them. I succeeded in persuading the patient to permit the same treatment for several successive months, despite the prophecies by lady friends of the terrible consequences of such a practice. The result of the treatment is, that the uterus is now per- fectly healthy and the lady enjoys better health than she has done for many years past, in fact is well. This and many other cases of a similar character emboldened me to use the same remedy in cases of profuse menstruation with symptoms of anemia and its sequelae, and finally to use it even where menstruation was considered to be normal or even scant, where I had previously been attempting in vain to make blood by the usual means. I am at liberty to state that I have not met with any un- pleasant or detrimental effects, and certainly have not had cause as a Curative Agent. 11 to regret the treatment. On the contrary, in almost all cases which I have so treated, and their number is large, the patients have been as highly elated with the results as I was myself. In many cases which have been in my care, or that of others for a long time, the first signs of improvement in the otherwise incurable diseases have been noticed soon after this treatment had been instituted. It is easily comprehensible that it takes a long time to collect satisfactory results of a mode of treatment which can be used not oftener than about once a month in an exclusively private practice. Therefore, I shall not prolong this article unnecessarily by a report of cases and other minor details, but shall content myself by having thus broadly stated the results of my ob- servations with the remark that further study of this plan of treatment, by myself as w'ell as others, may develop even more encouraging results than those here reported; while on the other hand the results may have been overestimated or misinterpreted by me. Further observations will help to decide in what class of cases and to what extent the remedy is admissible ; to what ex- tent the flow may be repressed with benefit, and what benefits may be expected therefrom. Heretofore I feared that I was standing alone in the proposi- tion of artificially restricting menstruation, as a curative means for many diseases which have been a stumbling block to gyne- cologists, and felt great hesitancy to come before the profession with such a proposition, but to my great pleasure and relief my eye fell upon an abstract in the Medical Times for June, 1888, of an article by Loewenthal in the Revue de Therapeu- tique which in a certain way serves to corroborate my observa- tions, and which, in the absence of the original article, I shall quote here in full. " Artificial Repression of the Menses in Chlorosis. " Loewenthal, of Lausanne, records twenty-three cases in which the artificial repression of the menses has been very advanta- geous in this disease. The method employed consisted in in- jections of warm water of about forty-nine degrees (Cent.), with absolute rest in bed. In some cases iced water was employed in preference to warm. Eighteen cases were chlorotic, and all were cured rapidly without other treatment than from three to 12 Gehrung : Repression of Menstruation. five menstrual suppressions. Five were grave cases of hysteria, one of whom showed marked improvement, while three other cases were convalescent from exhausting illness, and in them the convalescence was much shortened. No bad effects were noticed." The means employed by Dr. Loewenthal to effect the repres- sion appear to me of doubtful propriety, because of their un- certainty and dangerous character. My rale for submitting a case to the use of tampon has here- tofore been based on the answer of the following questions: How much blood does the patient lose ? And How much can she afford to lose ? If the sum of the former question proved to be in excess of the latter, I did not hesitate to use the tampon to a sufficient extent to limit the loss to the amount calculated, to the best of my ability. I feel quite convinced from my observations that a loss of from two to four ounces (sixty-four to one hundred and twenty eight grammes) will satisfy the demand in any case ; while in anemic persons, from profuse menstruation or from any cause whatsoever, all should be saved that can be saved. Even where no flow at all was permitted in such cases, no bad effect has been observed; on the contrary, the benefits were marked in propor- tion to the completeness of the suppression. If my estimate of the quantity of blood which should or may flow during menstruation is correct, then it is pitiful to behold what rivers of life are wasted monthly. I sincerely hope that in the future much of this waste may be arrested and used to a better purpose in the economy.