Some of the Limitations of Galvanism in Gynecology. BY WILLIS E. FORD, M.D., UTICA. REPRINT FROM VOL. XIV. (Sijttecofogtcaf Iransacftons. -1889. SOME OF THE LIMITATIONS OF GALVANISM IN GYNECOLOGY. BY WILLIS E. FORD, M.D., UTICA. REPRINTED FROM THE Transactions of the American Gynecological Society, SEPTEMBER, 1889. PHILADELPHIA : WM. J. DORNAN, PRINTER. 1 889. SOME OF THE LIMITATIONS OF GALVANISM IN GYNECOLOGY. By Willis E. Ford, M.D., Utica. Actual results, attained with much labor and experience, are hardly ever equal to the hopes and expectations so com- monly indulged in when a new invention or brilliant discovery is made in science, and yet it is this very enthusiasm that keeps alive the spirit of investigation which is always adding to our knowledge. When Apostoli first wrote of the modern use of the stronger currents of galvanism, the expectations of many, perhaps most of us, outran the natural limits of this agent. It may be profitable now to examine some of the facts which were at first stated, and to see what the actual results of galvanism may reasonably lead us to hope for its future. It is unquestionably true that, under the most favorable cir- cumstances, fibroid tumors of the uterus have been success- fully treated, but there is still a reasonable doubt whether subserous or large interstitial growths have ever been made to disappear entirely by this agent. Certain submucous growths have sloughed and come away when the negative electrode from a very powerful battery has been applied directly to them. Whether this latter process can fairly be called elec- trolysis of tumors, is very doubtful. It more nearly resem- bles electro-cautery. Pelvic exudates and even old indurated masses fixing the uterus in malpositions have been made to disappear also by these stronger currents of electricity. I was the first to call the attention of the profession to the 4 LIMITATIONS OF GALVANISM IN GYNECOLOGY. fact that peritoneal adhesions were permanently removed by galvanism.1 Just what change is produced in living tissues by galvanism has hitherto been largely a matter of speculation. Certain experiments recently made by me upon living animal tissues seem to point to some definite conclusions, not hitherto reached, and to intimate why the field of usefulness of gal- vanism is limited. I will refer to some of these experiments before reporting my clinical facts. It requires some care to obtain accurate measurements of electrical currents. The milliamperemeters I have seen all differ somewhat from each other, though the one I have (made by Gaiffe) is nearly correct, and two others by Liier vary but slightly. A Wheatstone's bridge of full size and Deprez deadbeat galvanometer, both instruments standardized, were used in these experiments, and the electrical facts, so far as given, can therefore be relied upon as being exact. The first point investigated was whether electrolysis produces any change in the interpolar space, or whether the clinical facts observed are due to changes that take place only at the electrodes. Fresh egg albumen in a watch-glass, under a microscope having a large field and about 150 diameters magnifying power, was subjected ten minutes to a current of 100 milli- amperes, with pressure or potential of 21 volts and resistance of 210 ohms. The electrodes were one inch apart. A white puffy mass was formed at each electrode, composed of coagu- lated albumen entangling minute bubbles of gas. The volume of gas eliminated at the negative pole was to that at the posi- tive as two to one, and proved to be oxygen and hydrogen gases. Across the interpolar space there was a slow move- ment of translucent fluid with wavy motion from the positive toward the negative electrode, alkaline near the latter and acid toward the former. On repeating the experiment under the same conditions, with magnifying power increased to 250 diam- 1 Medical Press of Western New York, April, 1888. WILLIS E. FORD. 5 eters, extremely fine filaments were seen extending into the interpolar space a little distance, and arranged in a curved form analogous to the curves which iron filings assume when placed between the poles of a magnet. Therefore, electrolytic and electrophoric action both seemed to be present in this interpolar space. The second experiment consisted of the dissection of the muscle of the thigh and leg of a rabbit under ether, and a current of 105 milliamperes, with a pressure of 9 volts and a resistance of 857 ohms, was passed through four inches in length of the muscle for five minutes, the wound dressed antiseptically, and the rabbit turned loose for a week. At the end of this time he was again etherized; the muscle was found to be shrunken, and though the wound had healed perfectly, there was at the point where the negative electrode had been placed, a cyst containing about a drachm of alkaline, straw- colored serum. The pathologist, Theodore Deecke, who ex- amined the muscle, reported that the muscular tissue was unchanged excepting for a short distance near each pole, where there was tonic contraction of the fibres that persisted several days in the fresh specimens that were kept on ice. No degeneration was found. The dried and therefore shrunken appearance of the muscle as compared with the corresponding muscle removed from the same rabbit at the same time, through which no electricity had been passed, was all that could be discovered. Another experiment of the same nature through three inches of a muscle of the live rabbit with a current of 15 volts, 22 milliamperes, and 681 ohms, was most carefully conducted, and the wound dressed and the rabbit turned loose. No new facts were elicited when the animal was taken up and the muscle dissected and examined, and fur- ther experiments on muscular fibres gave uniformly these results, viz.: Where, as in these experiments, the live muscles alone were used, care being taken to avoid large nerves and bloodvessels, the resistance to the current was considerable. 6 LIMITATIONS OF GALVANISM IN GYNECOLOGY. The results found in such muscles removed a week after the electrolysis are, a general appearance of dryness, slight shrink- ing in bulk, and microscopically no change in the muscular fibre excepting a condition of permanent contraction near the place of contact of the poles. No degenerative change could be found. The passage of a current of 15 milliamperes, with a pressure of 19 volts and a resistance of 1266 ohms, using salt sponge electrodes five minutes, directly through the ear of a rabbit, including the large bloodvessel which can be dis- tinctly seen in this animal when the hair is sheared, produced some atrophy and thinning of the tissues at the point of con- tact ; but after a week the artery was found not to be obliter- ated, though it was much smaller and contained less blood. On the other hand, a current passed through a space of four inches lengthwise of the ear, the platina tips actually piercing the bloodvessel, showed the following results : Using a current of 30 milliamperes, with a pressure of 9 volts and a resist- ance of 300 ohms, for five minutes, the artery was totally ob- literated, and when the animal was examined a week later collateral circulation had been partially established. In all the experiments, which were too numerous to relate here, the collection of an acid liquid at the positive pole, and an alkaline at the negative pole, was seen whenever they touched exposed tissues, and the bubbles in the fluids were similar in physical appearance to those observed in the experiments with albumen. From these and others in the same line, the conclusion seems inevitable that the changes produced in living tissues are mainly chemical, and due to the separation of the fluids of the body into more simple compounds, or into their ulti- mate constituent elements, and that this change is not con- fined to the point of contact of the electrodes, but takes place with more or less energy through the entire interpolar space. The fact so commonly observed of the bubbling of the alkaline, watery exudate in the vagina when the negative electrode is in contact with the projecting fibroid mass, is con- firmatory in part of the above conclusions. WILLIS E. FORD. 7 Some of this fluid was carefully collected, free from extra- neous matter, at the negative electrode. The patient had an intramural fibroid filling the brim of the pelvis and extending to the umbilicus. The current ufeed had 90 milliamperes, 16 volts pressure, 178 ohms resistance, and was passed for fifteen minutes. About half a drachm of transparent straw-colored fluid was obtained. Its chemical composition was chlorine, phosphoric acid, ammonia, sodium, iron, and albumen. It is probable that the combination was sodium chloride, acid phos- phate of soda, ammonium chloride combined with the iron as a ferri ammonium chloride. Under the microscope there were found little lumps of sediment consisting of spindle-cells and round cells with two to four nuclei, leucocytes, shrivelled blood corpuscles, and large bundles of broad connective tissue fibres, also bundles of fine fibrillae and small capillary blood- vessels. Some of these small capillaries were provided with an adventitious sheath, some of them contained shrivelled blood corpuscles and leucocytes, while others contained a solid fibrinous clot. There was no muscular tissue found, even sur- rounding these capillary vessels. There were also some irreg- ular-shaped epithelial cells and fat globules. This exudation of fluid, as is well known, is very abundant for the first forty- eight hours after the application of galvanism, and continues for several days, not unfrequently excoriating the vagina and vulva. If, then, it is true that the changes produced in the tumor are due to chemical changes in the fluids of the inter- polar space, it is useless to expect that a true muscular ele- ment will disappear rapidly under galvanism, or otherwise than as a result of the altered nutrition of the parts, and that complete disappearance is improbable unless the mass can be sloughed by the actual contact of electrodes. I have elsewhere stated the fact observed by me, that during the time galvanism has been applied at stated intervals, all patients suffer more or less systemic disturbance, and this would be quite expected if certain disorganized fluids had to be removed by the emunc- 8 LIMITATIONS OF GALVANISM IN GYNECOLOGY. tories of the body.1 The other fact, also noted in the same article, that some weeks after the discontinuance of galvanism, tumors so treated were found to shrink slowly, can only bo explained on the hypothesis that the nutrition of these neo- plasms had been permanently interfered with, and that atrophy was the slow result. The examination of the urine of patients under treatment showed great fluctuations in the amount of sediment, this uniformly being markedly greater a few hours after galvanism had been given than at any time between the applications. This sediment consisted mainly of an increase in the sediment that was found before using the galvanism. There were present in both cases amorphous urates, epithelial cells, and mucus; the acid reaction of the urine remained and the specific gravity was increased, from which I could draw no conclusion, though perhaps it might be considered confirmatory of the facts stated above. As to the effect of a current of electricity on the blood, experiments with rabbits showed that the current of 19 volts and 1266 ohms of resist- ance passed through the ear directly across a large bloodvessel, including cartilage and skin, did not permanently obliterate it, and the current was stopped only when the needles pierced the bloodvessel, when the resistance was very slight and the blood coagulated, permanently obliterating the vessel. A frog's tongue under a three-fourths inch objective shows arte- rial circulation to perfection, and without piercing the tissues but with blunt platina electrodes three-fourths of an inch apart, a current of 8 volts was passed, the resistance being 40 ohms, and the millamperemeter therefore marking 200. At the first contact of the electrodes a distinct spasmodic contraction of the bloodvessel was observed and a stopping of the current of blood. This was but momentary, and the blood slowly re- sumed its former rapid pace. After two minutes the current was markedly sluggish and seemed slower at the walls of the artery than at the centre, and finally came to a standstill. On 1 Translations of the Medical Society of the State of New York, 1889. WILLIS E. FORD. 9 removing the electrodes the blood slowly resumed its course, but after the current had passed four minutes the artery was blocked by thickly packed blood globules, and the sides of the vessel showed a slight milkiness due to coagulation of the albumen. On removing the electrodes the artery was found to be blocked. Here, again, the change due to electrolysis was of a chemical nature and the tissues were found not to be injured. From these experiments on the bloodvessels of living animals it would seem improbable that a current could be applied of sufficient strength to a fibroid tumor to produce any marked changes in the bloodvessels, unless the volume of the current was large enough actually to cauterize at the poles. The electrodes must get into the blood-current in order to change the bloodvessels. As to the effect of the current on peritoneal adhesions, the following experiment was most satisfactory. A large rabbit was etherized, the abdomen opened and closed again after the ordinary method of laparotomy. A week later the same rabbit was taken up and found to be in perfect health and vigorous. He was again etherized and the abdomen opened on the side and the flap thrown back, showing the site of the former incision. Here was found a firm adhe- sion of the small intestine to the abdominal wall, three- quarters of an inch in width and two lines in thickness. A current of electricity was now' passed through this from side to side by means of blunt electrodes, the current strength being 42 ma., 9 volts, and resistance 214 ohms. After about four minutes the band became soft and elastic, and after five minutes parted without any appearance of cautery. The wall of the intestine was uninjured and scarcely congested. The shrivelled stump of the adhesion remained attached to the ab- dominal wall. Further on, a similar band of adhesion of equal firmness attached a portion of the omentum to the abdominal wall. The negative electrode was placed near its omental attachment, and the positive current was dispersed on the ab- dominal wall at some distance, and a current of 40 ma., 15 10 LIMITATIONS OF GALVANISM IN GYNECOLOGY. volts, resistance 375 ohms, was passed. The adhesion readily parted at the end of three minutes without injury to the omen- tum and without any cautery effect. In both instances an alkaline fluid was plainly seen to collect at the negative pole and a less amount of acid fluid at the positive pole. Further experiments on adhesions did not offer anything new. It is difficult to escape the conviction that new-formed tissues, the result of serous exudates, having but few blood- vessels, if any, show the destructive effects of a current of galvanism, though a higher resistance to the current than the adjacent tissues in which there is a normal circulation of blood, which are left comparatively unharmed by the same current. By careful measurements, I have found the normal resistance of the tissues between the vaginal electrode pushed firmly into the vagina in front of the cervix, and the large abdominal dispersion plate in a healthy, well-nourished woman to be 44 ma., 15 volts, 340 ohms. In Douglas's cul-de-sac, behind the cervix to be 46 ma., 15 volts, and 326 ohms. In a thin sub- ject about one-third less. Using the blunt end of Apostoli's platina needle introduced well up to the fundus of the normal uterus, the resistance was 288 ohms. Of course, these resist- ances differ greatly in different individuals, and I have only introduced the readings of the current in these two healthy women, in order to be able roughly to distinguish between normal and abnormal tissues in their resistance to the electri- cal current. A fibroid (interstitial) which had been under treatment for a month, and was, therefore, somewhat lessened in size, but was still as large as a cocoanut and nearly sym- metrically round, at this time being movable and free from adhesions, and with the negative oval-shaped platina electrode an inch in diameter against the vaginal protuberance, the posi- tive current being dispersed over the abdomen on a one foot square surface, the current measured 52 ma., 15 volts pressure, and showed a resistance of 288 ohms. The intra-uterine electrode 78 ma., with pressure 15 volts, showed a resistance of 192 ohms. WILLIS E. FORD. 11 A much larger interstitial fibroid, too broad at its base to get into the pelvis, and extending two inches above the um- bilicus, also free from adhesions, showed with intra-uterine electrode (current in all cases dispersed as before) 50 ma., volts pressure, and 333 ohms resistance. The intra-vaginal electrode showed 100 ma., with a current of 16j% volts and 166 ohms resistance. A fibro-cyst, with solid part the size of a large orange, and with perhaps three pints of fluid above, adherent, but with no free fluid in the abdomen, showed with intra-vaginal elec- trode against the solid portion, 80 ma., with a current of 16 volts pressure, 208 ohms. An ovarian tumor of three years' growth, with small appre- ciable amount of solid material, springing from the left side, and fairly filling the abdomen to an extent at least as great as the eighth month of pregnancy would do, showed with intra-vaginal electrode 50 ma., with a current of 16T volts pressure a resistance of 333 ohms. Here the resistance was so considerable that the vagina was thoroughly cauterized by the negative electrode, though there was little inconvenience from the burning of the dispersion - plate on the abdomen. It would, therefore, be impossible to force much of a current through this cyst without danger of injury at the negative electrode. The following experiments were now made with a view of throwing some light on the behavior of ovarian cysts under electrolysis. An artificial cyst wTas made of a small India-rubber balloon three inches in diameter filled with pure egg albumen. Plati- num foil electrodes, of one square inch surface each, were intro- duced within the cyst, and a current of 33 ma., with pressure of 9 volts and 272 ohms resistance, was used. A white clot filled with minute bubbles, and giving a decided acid test, was formed at the positive pole, while a tumid mass with larger bubbles, of alkaline reaction, and about twice the size of the other clot, was formed at the negative electrode. A second cyst of identical size and under the same condi- 12 LIMITATIONS OF GALVANISM IN GYNECOLOGY. tions was then filled with an intimate mixture of egg albumen and saturated sodium chloride solution, equal parts. A cur- rent from the same battery and connections as before gave 22 ma., 9 volts, and 409 ohms. The resistance was unex- pectedly large. The experiment was repeated with the same results. These experiments repeated and varied somewhat, gave the one significant fact that pure albumen, a high chemical com- pound, has a resistance not differing materially from that of a fibroid tumor. Where an alkaline solution of albumen is made, the resistance is nearly doubled. The resistance of live muscle is nearly twice as great as that of a fibroid tumor, about -the samezas that of an ovarian cyst, and the same as the solution of ajburaen in salt-water. When dead animal tissue was 'examinedlthe most astonishing results were obtained, which showed how little analogy there is between the action of electricity in living and in dead tissue. An intercostal muscle of a lamb was taken five hours after death, cold, and platina • electrodes one inch and a quarter apart, time five minutespcurrent 21 volts, the resistance was 11,000 ohms. Some kidney fat from the same animal, undis- turbed, the electrodes one ihch apart, a current of 21 volts showed a resistance of 3070 ohms. I regret that I had but one ovarian tumor available while preparing this paper, and that I did not on former occasions measure the resistance of such growths. 'But I never enter- tained the idea that galvanism would benefit ovarian tumors, and until I got into this subject it did not occur to me to find out why it would not benefit them. From the facts and experiments detailed above, it seems probable that the fluid within these growths offers very unusual resistance, and that from this fact galvanism fails. I see no physiological reason, however, that should deter from further experiments, and, in cases that refuse operation, gal- vanism should be tried with a view to ascertain whether the growth may not at least be checked in such cysts. I have had under actual treatment by galvanism during WILLIS E. FORD. 13 the year from July 1, 1889, to July 1, 1889, seven cases of sub-serous fibroids, eleven of interstitial, three of submucous, and three of fibro-cysts. Very few' applied for treatment because of the presence of the tumor alone, but usually because of pain or of difficulty of locomotion from the pressure and fixation of the growths. The submucous fibroids have disappeared partly by sloughing and partly by absorption. The others have not disappeared, but have been reduced in size from one-quarter to one-half, and in all cases the pain and the adhesions have disappeared, and the general health of the patients been restored. Too little time has elapsed to show' the permanency of these results, though in two years and a half of this work there has been no instance of a return of the grow'th, excepting in submucous fibroids, and the uniform testimony has been that improve- ment continues. Case I.-The largest fibroid I have ever seen was treated two and a half years ago, the measurement about the body below the umbilicus being fifty-seven inches. The patient was an unmarried woman, forty years of age, who had observed the growth about seven years. Before coming under my observation she had had two sharp attacks of peritonitis, producing in each in- stance a long sickness, and resulting in such extensive adhesions as to prevent her doing any work for the last year or more. Her figure was that of a woman in the last month of pregnancy. The current used was from a small cup battery, and, therefore, of higher tension than I now use. After twenty applications of eight minutes each, at intervals of three days, she was able to move about easily without pain, and the tumor was free from adhesions. She returned home, and afterward wrote me that for the succeeding three months she was in bad health; was weak, and had a poor digestion. Subsequently she resumed work, and after two years wrote me she had worked steadily without sick- ness, and that the tumor was twelve inches less in its measure- ment than when she discontinued treatment. The measurements of course may be inaccurate, but the fact that she is a well woman two years after treatment remains. 14 LIMITATIONS OF GALVANISM IN GYNECOLOGY. Case II.-A woman, aged thirty-six, married, three children, the last one thirteen years old, was operated on by me four years ago for lacerated perineum with rectocele. She had at the time a sub-serous fibroid the size of an orange growing from the pos- terior wall of the uterus, causing much discomfort from pressure. It caused almost complete retroversion uteri. I hoped that with good vaginal support a pessary would remove the disability. The improvement was slight and temporary, for the fibroid in- creased in size and no support held for a long time. A slight laceration of the cervix justified, perhaps, an operation here, and I made the incisions deep and removed the cicatricial tissue up to the vaginal junction. Some improvement followed, but about this time Apostoli's paper appeared, and I at once began galvan- ism. The relief of symptoms was speedy, so that I did not have to urge the continuance of this treatment. After four months of treatment at intervals of a week to ten days, the patient reported herself comfortable. Since beginning this article, I have exam- ined this case, and find the general health restored, the uterus small and in position, menstruation normal, and it is difficult to detect the thickening of the posterior wall of the uterus where the fibroid was attached. Case III.-A woman, forty years of age, married, nulliparous, was brought to me in May last. I found a uniform enlargement, peaked perhaps a little at the umbilicus, filling to distention the abdomen, with the uterus drawn high up out of the pelvis. It had a history of four years' slow growth, springing from the left side, and for six weeks proceeding her admission to the hospital a rapid and alarming increase in size, apparently upward, so that the dyspncea had become very great. I opened the abdomen and found I had mistaken a large fibro-cyst for an ovarian tumor. The cyst was at the apex, contained not a large amount of fluid, enclosed in a sac that was richly studded with bloodvessels, and that looked like an ovarian cyst. I closed the abdomen, and in twenty days began the use of galvanism. After twenty applica- tions the top of the hard mass was on a level with the umbilicus, and seemed reduced nearly one-half in all its dimensions; was freely movable in all directions; caused no inconvenience in walking, and the woman went home in comfortable health. The WILLIS E. FORD. 15 fluid in the cyst is certainly gone. The current used was one- third ampere, with sixteen to twenty-four volts to push it, and the milliamperemeter marked from sixty to ninety during the sitting. Case IV. was also a fibro-cyst, springing from the left cornua, having a solid base the size of an orange, and a sac that was estimated to hold three pints. On the right side was a well- defined ovarian cyst that extended to the short ribs, and must have had a capacity of sixteen pints. Treatment was begun with the vaginal electrode, and after the mass became more movable, so that the intra-uterine electrode could be used, this was alter- nated, because of the sloughing caused by the negative pole. The abdominal plate was two feet long and one foot broad, and a current of eighteen volts pressure caused the milliamperemeter to mark from 80 to 110. The patient complained bitterly of the burning on the left side of the abdomen, but declared she felt almost nothing over the ovarian tumor. Indeed, if the abdominal plate was applied to a small surface over the fibro-cyst, the mil- liamperemeter marking 110, and then the plate moved gradually so as to cover only the ovarian tumor, the milliamperemeter would at once run down to 60 or 80. The treatment has been continued up to this time, sixteen applications having been made, with the result that the fibro-cyst is one-half its former size, allow- ing the ovarian tumor to roll up into the median line, while the abdomen is no longer tense, but quite flaccid ; locomotion is easy, and the two growths can be made out with the greatest ease. The patient thinks the ovarian growth is not so tense nor so large, but it seems to me this is due rather to the relief from out- side pressue and change of position than to any appreciable lessening of its contents. Indeed, the important fact that the resistance is markedly greater through this growth than through other tissues, makes it certain that an electrical current will find its way about the mass, and not through it, unless the electrodes be placed inside the cyst walls, an obvious impossibility. The limits of this paper will not permit me to speak at length of other conditions in which I have found galvanism useful, to which I can only briefly refer in this place. Fif- 16 LIMITATIONS OF GALVANISM IN GYNECOLOGY. teen cases of fixation of the uterus in malpositions, the results of various peri-uterine inflammations, were satisfactorily re- lieved by galvanism. Here the current proved most useful which had large volume and but comparatively small pressure, and from twelve to twenty applications at intervals of three days were sufficient. A rather large vaginal electrode tipped with platina is pushed up against the resisting point and the positive current dispersed over the abdomen in the ordinary manner. The same transudation of an alkaline fluid takes place into the vagina as has been described before, and the adhesions certainly disappear. As shown by actual experi- ment, these peritoneal adhesions have high resistance, much higher, for instance, than fibroid tumors, and yet they are small in bulk and can be brought so immediately into the current and the distance to be traversed is so small that their electrolysis is comparatively easy. I am convinced that danger lies in the use of these currents while inflammatory action is still present, and once in my ex- perience the serious result of an abscess occurred, lighted up, as I believe, by the current. In the light of these experiments, it seems reasonable that the chemical degradation of the fluids in a congested or in- flamed mass, by the passage of the current, directly favors the formation of pus. In view of these facts also, one would hardly think of plunging a needle electrode into any sort of tumor within the abdomen unless the passage of the needle also made a drainage for the disorganized fluids caused by the electrolysis. Abdominal puncture can never be justified in the light of our present knowledge of the actions of the stronger currents of electricity upon the fluids of the body- Chronic metritis, of which I have notes of fourteen cases under treatment during the year, seemed to do as well by passing the current directly through the whole uterus from a vaginal electrode as when the intra-uterine electrode was used, and, curiously enough, the resistance to the current in the in- stances in which it was accurately measured, was not mate- WILLIS E. FORD. 17 rially greater. The shrinking of the uterus is marked and the change in the nutrition of the organ and restoration of normal circulation are easily accounted for by the intense chemical activity between the poles. Watery exudates, such as hydrosalpinx and fluid free in the abdominal cavity, due to chronic peritonitis or to pressure, disappeared readily, though the current required high voltage. This subject must be left to some future time as it is too im- portant to be briefly treated, and the same must be said of pus cavities and the behavior of pus and of blood under a current of electricity. As to apparatus, it is apparent from the foregoing remarks that a generator of electricity to be of the greatest service in gynecology, must deliver a current in which the amperage and voltage may be changed at will. This is not possible with a stationary two-fluid battery, unless the coupling of the cells be changed frequently, which is quite out of the question. So, too, in a current from a dynamo the relative proportion between the amperage and voltage of the current cannot be changed. A rheostat is simply a resistance which impedes the flow of both elements of any current. The simplest form of battery, namely, the zinc-carbon, with bichromate fluid is best. The cups or cells must, however, be large, holding at least a quart each, in order that the current may have per- manency and also that it may have amperage. A number of cells coupled together in series will not give greater amperage than will one cell of the series, and a quart cell, with zinc eight inches by three, immersed, will give, roughly speaking, a third of an ampere. Such a cup gives from 1 to 2 volts. Now, lowering the zincs and carbons to different depths, will, of course, change the amperage, while the voltage depends upon the number of such cups used. Such a battery main- tains its strength for a considerable time, is easily renewed, and requires but little attention. It has been my intention to present facts simply and to avoid theories in this paper, and I have, therefore, omitted 18 LIMITATIONS OF GALVANISM IN GYNECOLOGY any reference to the literature of this subject. A patient search in current literature, however, has not been rewarded by as accurate and as definite statements regarding galvanism as I expected. As a basis for further observations, I think the following conclusions can be accepted : First. There is a change in animal living tissue wrought by galvanism, in the entire interpolar space. Second. This change is a chemical disintegration, mainly of the fluids. Third. The tendency of this chemical change is to convert the higher and more complex combinations of matter into simpler compounds. Fourth. Electrolysis of recent inflammatory products, or by introducing electrodes into inclosed fluid masses, is likely to produce pus, and is therefore dangerous. Fifth. The resistance to the electrical current varies greatly in different animal tissues, and may be so .great in a large mass, as, for instance, in an ovarian tumor, as to make it probable that galvanism will not affect it. Sixth. The bloodvessels and muscular fibres are not easily affected by galvanism unless the electrodes pierce them. Seventh. Electrolysis, to be successful, requires a battery of special adaptation.