For the Medical and Pharmaceutical Professions Only 1 Reprint of a Paper Published in the December, '93, Number of the Druggists' Circular- Entitled A Filtering and Distilling Cabinet By W. H. Hostelley V W. H. Hostelley & Co. MANUFACTURING CHEMISTS PHILADELPHIA •SY K. AC ID MY D KIO DIG -HOSTELLEY'S •THE- EIHE5T- FREFARATIOHOFHYDKIopiC ACIDoHTAEMAKKEY' Prepared by a new process and preserved in glycerin. It is generally recognized as the highest expression of pharma- ceutical skill in the manufacture of this delicate product. THE IDEAL FORM OF IODINE. Being superior to the alkaline iodides, inasmuch as it is more readily absorbed and better borne by the stomach, pro- ducing none of the evil effects of potassium, ammonia or sodium iodides. AS AN ALTERATIVE. In conditions suited to its use, the Syrup will be found a prompt and eIIl efficient alterative, so agreeable to the taste that it is readily accepted by the most fastidious, while its slight '■>< ' | * W acid reaction rather promotes diges- * g j tion than retards it, as do the alkaline iodides. In fact, it seldom fails to sharpen the appetite and promote assimilation, displaying this property to a marked degree, even in cases where other treatment fails to pro- fatwswep". duce the desired results. INDICATIONS. Strumous Conditions, Asthma, ' - AN D Chronic Bronchitis, Psoriasis, Ca- tarrhal Conditions, Sciatica, Lead Poisoning, Hayfever, Spinal Sclero- sis, Glandular Enlargements, Syph- ilis, Rheumatism, Adenitis, and all conditions wherein Iodine is used with advantage. DOSE..-The usual dose of the Syrup is from two and a half to four cubic centimetres (four minims to a teaspoonful). After tolerance is established a larger dose may be given- about eight C.c. Always dilute with water. Supplied by all Principal Druggists. W. H. Hostelley & Co., Hostelley's Manufacturing Chemists, Hypophosphites. Philadelphia. A Filtering ^Distilling Cabinet. W. H. HOSTELLEY. " Foul cankering rust the hidden treasure frets, But gold that's put to use, more gold begets." THUS wrote the immortal bard of Avon, and if it is true of treas- ure in gold, it must apply with equal force to wealth of another nature. The writer has devised an apparatus for use in the laboratory, which has in his hands proved such a veritable treasure, that, in the belief that it would be of equal value to thousands of co-workers in the fields of pharmacy and chemistry, he offers the invention. It is felt, if the pharmacist puts to use the information herein contained, it will, if not more gold beget, at least enhance greatly his wealth of laboratory helps. We all recognize the wisdom in the old adage, " A place for everything, and everything in its place," but do we practice it? Sometimes. Who should practice it more than the druggist ? Yet, take a look about the pharmacy, and how do you see the filtering conducted ? Is not the outfit likely to be a funnel stuck in the neck of a bottle, a paper over the funnel, and the whole standing in a perilous position, near or on the prescription section, where, in the rush of business, it is likely to be knocked over ? It may be placed under the section, where, being entirely out of sight, it is almost, or quite, forgotten. Where is the process of percolation carried on ? True, some pharmacists-there should be more-have a place where percolation is conducted, but, ordinarily, is it not anywhere about the store, wherever the fancy of the operator sug- gests ? There is a section in every store for herbs, one or more for tinctures ; fluid extracts have their place ; pills are provided for ; ointments, too ; and the proprietaries are frequently honored with an exclusive resting-place ; though too often the most important operations in pharmacy, those that most of all gauge the real prac- tical ability of the pharmacist, are treated like wandering outcasts ; a home here or there, but seldom a fixed abiding place. Surely, 1 every complete pharmacy-and every pharmacy ought to be com- plete-should be provided with a place exclusively for at least the heavier operations of filtering, and all the operations of percolation. No pharmacy, in my mind, can be called complete without such a department. It gives the writer pleasure to offer, and describe in detail, a piece of furniture which he believes will meet the requirements, and fill a vacancy which more pharmacists than himself have felt. The apparatus to be described is a cabinet, conveniently ar- ranged for facilitating the important manipulations referred to- filtering and percolating. It may also be used in the process of distillation, though it will be found most useful in the two former operations. The manner of constructing the cabinet will first be Fig. i. described, and then its several important features referred to. It will also be shown how the cabinet is calculated to aid the phar- macist in his routine of laboratory work ; no, not calculated to aid, but how it will aid if put to use. This is no experiment; the writer has been using two of these cabinets for over a year, and would rather dispense with any other laboratory apparatus than with these useful pieces of furniture. Here is a description of the cabinet: A case is made, 3 feet high, 2 feet 4 inches long, and 15 inches wide; these are outside measurements. The front of the case is composed of two doors, in which glass has been set, so that the inside of the case or cabinet can be readily 2 seen without opening the doors. These doors are, of course, hinged on either side and fastened together with a catch in the center. Now we have the plain case, which in the following descriptions will be referred to as a cabinet (Fig. 1). The back view, which will be further referred to, is shown in figure 2. Fig. 2. The top of this case is fitted with lids, two in number, each the same size as the other, and each hinged from the back. Through the center of each lid a hole is made, inches in diameter, and crowning each orifice is a disc of wood 4^ inches in diameter, through the center of which is a hole the same size as the one in the lid This is fastened on, so that, as said before, it forms a crown for the perfor- ation in the lid. This opening is in- tended to receive the neck of an inverted bottle, and the crown supports the same. The latter may be reamed around the edge of the perforation to better fit the shoulder of a bottle (Fig. 3). pro. 3> 3 The funnel supports are made of a strip of hard wood, just the length of the cabinet (inside measurement) and i inches thick by 2 inches wide. A groove is run along one edge of this strip, from one end to the other, ^4 of an inch wide and ^4 of an inch deep (Fig. 4). Two such strips are required, one for either side of the cabinet, and are fastened inside 1% inches from the top, with the grooved side toward the top of the cabinet. These will, if placed as described, support two ordinary gallon funnels. Slight depressions may be made in the edges of the strips so that the fun- nel will rest easily and solidly in place. The next step is to place in position those parts which will make it possible to support any size of funnel or percolator, and for this purpose we must use some device which is at once simple and easily adjusted to any shape, as well as any size, of percolator or funnel which the varying operations of pharmacy call upon us to use. Here is a description of the simple little scheme : A block of hard wood, 4 inches long, ^4 of an inch thick, and one inch wide, is notched on one side transversely. Sixteen such notches are made, each of an inch deep, and pointed toward one end of the block like the teeth of a saw. On the side of the block opposite these transverse notches there are 24 notches cut along the edge of the block. The teeth of these notches are to point in the reverse direction of those previously described (Fig. 5). Bight such blocks are necessary ; four with teeth pointing in one direction, and four with teeth pointing in the opposite direction. These are placed in the grooves (see A, Fig. 4) in such a manner that, when there are two funnels in the cabinet, the transverse notches on four of the blocks will point toward one of the funnels, and the notches in the other four will point toward the remaining funnels. The next step is to describe the cross- pieces or ' ' rests ' ' upon which a funnel or percolator reposes during operation. These are made from a piece of hard wood, 1 inch square, and just long enough to fit across from block to block. A tongue is made on each end so that it fits easily into the notches on the blocks above described (Fig. 6). There are four such cross-pieces, two to support each Fig. 4. Fig. 5. Fig. 6. 4 funnel or percolator used. Depressions may be made on one side of these ' ' rests ' ' so that the funnel or percolator will fit snugly between them. To complete the arrangement of this portion of the cabinet, 8 little button catches are fastened, one above each notched block (Fig. 5), so that, when pressed down into the notch on the edge of the block, the whole moving portion is fastened in any position desired. One of these little buttons holding the block as described is shown at A, figure 7. The object of having- small notches on the back of this movable block, controlled by the button described, is to facilitate finer adjustings when a long, slender percolator is used, a percolator like the Oldberg, for example. Fig. 7. Fig. 8. Now this portion of the cabinet is completed, and while it takes a rather lengthy description to make it clear, which I hope has been done, it is really very simple, and at the same time fills every neces- sary requirement. The arrangement of the supports is shown in figure 8. As the cabinet is self-feeding, a fact previously hinted at, and as a gallon or two-gallon bottle filled with menstruum and inverted is somewhat top-heavy, there must be some contrivance that will hold the bottle upright and remove all anxiety as to it falling over or being knocked off by any sudden movement. The first thing aimed at is, of course, simplicity ; not only simplicity of construction, but especially simplicity of operation ; something that can be adjusted in a few seconds and yet hold the bottle rigid. Here is a description of the device employed : An iron rod about inch in diameter and 3 feet 4 inches long is bent at one end so that if placed against the back of the cabinet, with the bent part over the top and pointing toward the opening in the lid, the bent end of the rod will come directly over the center of this open- ing. On the bent end of the rod described, a wooden hemisphere is securely fastened. This should be 2 inches in diameter and placed on the rod as shown in figure 9. To fasten the rod on back of the cabinet so that it is easily adjusted to any height, four pieces of hard wood are used, each 1 inch wide, % inch thick and 6 inches long. A groove is made in one side of these pieces, so that the rod above described will just fit nicely into it. These grooved pieces are fastened on the back of the cabinet, well up toward the top, and on a direct line with the perfor- ation in the lid. A space % of an inch wide is left between each two strips, and in the center of this space a hole is bored through the back of the cabinet. In the opening thus made-which should be about of an inch in diameter-is placed, from the back, a screw- eye, the loop of which will admit of the passage of the iron rod, and the thread of which will protrude y? inch on the inner side of the cabinet. On this thread is screwed a button of very hard wood- hickory will do, or gum is good on account of its cross grain. The rod is now run down these grooves and through the screw-eye, and the arrangement is complete. A separate drawing of this is not deemed necessary, as a faithful idea can be gathered from the follow- ing cuts. When a bottle is inverted in the lid, bring down the rod until the disc rests on the top of the bottle, press the top of the rod a little and turn the button inside the cabinet. The container is thus held solidly in place. This is not complicated, as can be seen ; the fastening of the bottle can be done in less time than it takes to Fig. 9. 6 explain its operation. The arrangement is shown in figure 2. There is left now but one feature of the cabinet to be arranged, and the whole piece will be finished and ready for use. Two sliding platforms are to be adjusted, one on either side of the cabinet-inside-and so arranged that they can be instantly elevated or lowered at the will of the operator, and remain solidly at any elevation desired. This is accomplished by fastening securely on the side of the cabinet-we are now speaking of the inside-a strip of hard wood, of an inch wide, ^6 of an inch thick, and two feet long. This is fastened in the center of the side, in a perpendic- ular position, one end resting on the bottom of the cabinet. Another piece of hard wood, inches wide, % inch thick, and the same length as the former, is fastened on top of the first strip, letting it project over evenly on each side. Now another strip, identical with the first in size, is fastened on top of this just described. This last strip is to be transversely notched with nicks about 3-16 of an inch deep and % of an inch apart. These notches, like those previously described, are to be made like the teeth of a saw, and the strip is fastened on so that the notched side is toward the center of the cabinet, and the notches pointing upward. The whole piece is shown in figure 10. One of these notched devices is to be placed on either side of the cabinet. These are to support the platform, which will now be described : A piece of strong wire, a little heavier thar telegraph wire, is bent into the shape shown in figure 11. The ring part is to be 5 inches in diameter, anc the distance from the ring to the end of the claws (D, Fig. 11) is 2^ inches. A piece of smaller wire is fastened around the narrow part, where the heav> wire meets to form the circle (C, Fig. 11). This holdsit firmly together. Next, a piece of wire, 12 inches long, and the same thickness as the first, is bent into the shape of a wish bone, with ^4 of an inch at each end bent out at right angles. The latter wire now presents the appear- ance shown in figure 12. The idea is easily grasped ; when the bent portions A A, figure 12, are placed into the loops B B, figure 11, the ring with bracket support is complete. Two of these are required, one for either side of the cabinet, and are adjusted as shown in figure 13. As can be seen, the ring may be run up and down this notched scale and made to dwell at any point Fig. io. Fig. ii. Fig. 12. 7 desired, or can be removed at will. This is necessary in some operations, where, if not re- movable, it would be an encumbrance. The ring above described will hold a funnel, flask or retort, but for supporting a receiving bottle or jar, for which purpose the bracket is chiefly intended, it is necessary to fit to this a remov- able platform, which is done in this way : Out of a piece of board 3^ of an inch thick is cut a disc 6 inches in diameter. From another board of an inch thick, is cut a second disc, 5 inches in diameter. This is fastened securely onto one side of the first disc so that % inch space is left on all sides, this disc being just 1 inch smaller than the first. On one side of the smaller disc is securely fastened a small wooden button in such a manner that it projects over the side of the disc % inch. On the other side of the same disc is placed a movable button, in such a way that, when both buttons are pointing in the same direction, the latter button will also extend over the side of the disc % inch. The platform will now present the appearance shown in figure 14. The manner of adjusting this platform hardly needs explana- tion. The stationary button is simply run under the wire of the ring, the movable button having been turned aside. The small disc fits easily into the ring ; the button is turned back, and the platform is thus made fast. These buttons are not absolutely essential, but it is well to have them to avoid danger of tipping. The cabinet itself is now complete, as shown in figure 15. While the manner of constructing the cabinet has been described, there yet remains one feature to be spoken of, and while it is not a part of the cabinet proper, the latter would be of less value without it. This is the device for the self-feeding of the funnel during the process of filtration, or of the menstruum during percolation. There are in books on the subject of pharmacy descriptions of tube- feeding devices, the most frequently shown consisting of a single tube run through a perforated cork, which is to be placed in the neck of a bottle and the same inverted. This method is sometimes practically used, though, as is well known, where this form of self- feeding is employed, it is necessary to have a large tube, and if rather long, it will not feed freely even then, on account of capillary attraction. With thick, heavy liquids, the process is usually unsat- isfactory. Aside from these objections, the difficulty of procuring a rubber cork-and rubber is much the best-having large perforation, with many forms a barrier to its use even where it would answer. Fig. 13. Fig. 14. 8 The form of self-feeder designed to be used with this cabinet, and which I have found to be admirably adapted to all purposes, consists of two glass tubes, each of about ^-iiich bore, one long and the other short. The exact length of these rods will depend upon the depth of the feeding bottle, and the distance from the mouth of the same, when inverted on the cabinet, to the liquid in the funnel or percolator. For the cabinet described, when an ordinary gallon bottle is used, the lengths are: Fong tube, 15 inches; short tube, 3 inches. They are placed in a perforated rubber cork-a cork having two perforations-the long tube reaching nearly to the bottom of the bottle, and the short one just showing through the cork on the inner side of the bottle. The short tube should extend % inch further outside of the bottle than the long one. The long tube is for admitting air to the bottle, without which the operation would not proceed, and the short tube is for supplying the liquid to the receptacle below. As the liquid in the funnel or percolator falls below the air tube, air is at once admitted to feeding bottle, which causes the necessary atmospheric pressure, and the process proceeds until all the liquid has been fed. The reader is heard asking if a Fig. 15. 9 thick, heavy liquid will feed through such a small tube in the man- ner described. Yes, it will, and freely, too ; in fact, the cabinet and feeder were first devised expressly for filtering heavy syrup of hydri- odic acid, composed largely of glycerin. For the past twelve months four of these feeders have been kept running almost constantly on this product, and, to my knowledge, they have not clogged once. That is the best example of their satisfactory working that can be given. For the heaviest syrups I use a tube of only 3-16 inch bore. The entire mechanical construction of the cabinet and its attachments have now been explained, and, it is hoped, made clear. I will now proceed to review the various uses to which the cab- inet may be put, and endeavor to explain, by the use of drawings, the most convenient manner of conducting the different operations. First and foremost in pharmacy comes the process of filtering, for surely there is no performance in the round of laboratory work more frequently conducted. For this purpose the filter bed is made in a funnel, which has been properly arranged in the adjustable rack (see Fig. 15), the funnel is filled to the top of the bed, and the feeding bottle, which has been nearly filled with liquid to be filtered, is inverted over the funnel, the neck through the perforation in the lid support is tightened on top of the feeder, and the arrangement for filtering is complete. All the care required is to replace the re- ceiver below, when filled. The process is automatic and continuous until the product is finished. A 5-gallon bottle may be used for a feeding bottle as well as 1 gallon, and where large operations are in hand, this is advisable. Attention is here called to a form of filtration which is exceedingly useful in treating syrups intended for medicinal use. The pharma- cist has for some time noted with disfavor, not to say apprehension, the excessive amount of ultramarine which the refiners are using in their granulated sugar. This is certainly detrimental to a medicinal product into which it enters, and is especially objectionable in elixirs. Here is a scheme which will remove a goodly proportion of the blue : Arrange a gallon funnel on the supports of the cabinet, and into the neck of this funnel pack tightly a small sponge, which has been previously moistened. Remove the platform from the ring inside of the cabinet, and place in this ring another and smaller funnel, into which also pack, though not so tightly as the first, a small moistened sponge. Into the neck of the receiving bottle, which should stand upon the bottom of the cabinet, place another funnel, packed with sponge in a similar manner, though not so tightly as either of the others. Start the syrup filtering and conduct the process as shown in figure 16. At the end of the operation much of the ultramarine will be found on the three sponges. This idea of 10 three funnels is applicable to other forms of filtering, the triple process being conducted in about the same time that it would take to manage a single operation. There is one other form of filtering which should be mentioned in this connection, and this is a form which is very useful in clarifying thick, heavy liquids which pass through the filter beds slowly, or where time is an object. I refer to forced or vacuum filtration. This is conducted in the following manner: In one side of the cabinet arrange the funnel and feeder as in ordinary filtration. In the end of the funnel fit a perforated cork, into the per- foration of which there has been placed a small glass tube, projecting down 2 inches from the neck of the funnel and flush with the top of the cork inside of the same. Arrange in a similar manner two glass tubes in the neck of a re- ceiving bottle, which is placed in an elevated position on the platform, immediately under- neath the funnel. Connect one of these latter glass tubes, by means of a closely-fitting rubber tube, with the glass rod in the funnel described. Now fill a large bottle with water, adjust the self-feeding tubes previously referred to, put a small plug in the end of the short tube-the end outside of the bottle-and invert the same in position on top of the cabinet. Place a receiving bottle directly underneath, and on the bot- tom of the cabinet. Next connect the air tube of the tank bottle with the remaining tube in the receiving bottle under the funnel. Having done this, place on the platform of the cabinet-the one directly under tank bottle-a hydrometer jar. To complete the arrangement, secure a long rubber tube, one end of which is to run into the neck of the receiving bottle under the jar, and the tube wound around the latter until it reaches the short stoppered rod in the tank bottle. Remove the plug from this rod and slip the rubber tube over the same. This process is pictured in its entirety in figure 17. The cabinet is not shown in this drawing, but the arrangement of the apparatus in the same can readily be traced by the figures exhibited. As the water leaves the tank bottle A by way of tube B, falling into the receiver C, a partial vacuum is produced in D, and as the atmospheric pressure is thus removed, the liquid to be filtered more freely runs through tube E. It may appear to some that the rubber Fig. 16. 11 tube B is superfluous ; in reality it is one of the most important con- nected with the operation, as it is this tube which, by its length, gives the suction power necessary to exhaust the air from the receiver D. The longer the tube, the greater is its suction power, though it should never be run further into the bottle indicated by C than is shown in the drawing. Fig. 17. I cannot refrain from making a parting remark about this form of conducting forced filtration. I am familiar with many methods and have used most of them in the laboratory, but the arrangement above explained is, in my thinking, the simplest, and at the same time the most effectual, that I have ever used or seen used. The apparatus for its construction is found in every pharmacy, and the process is especially adapted to the requirements of the retail 12 druggist. Let this remark be emphasized, however : See that all tube connections are tight. While the subject of filtration, as applied to the cabinet, has not been exhausted, its most important features have been reviewed, and now a word in reference to the subject of percolation. While probably not so frequently conducted as filtration, the importance justly attached to this process is shared by few other operations in pharmacy. It is not thought necessary in this connection to refer at any length to plain or ' ' straight ' ' percolation, as this is so simply carried on in the cabinet that the manner of operating will at once suggest itself. It is well, however, to call attention to official percolation, as the cabinet is especially well adapted to this use, as will be seen by explanation, the movable platform being the particular feature of elegance in this connection. In fact, I feel that somewhat of a treat is in store for those admiring and using official percolation-all should use it, but do we all ? By referring to figure 18, it will be seen at a glance how official percolation may be conducted conveniently and simply by the inter- vention of this new device. To entirely stop the flow of the percolate raise the platform so that the end of tube A is above the level of the liquid in percolator B. To start the flow, lower the platform ; by raising or lowering the latter, the flow may be instantly regulated to conform to the ten to thirty-drop requirement of the Pharmacopoeia. Figure 18 shows the percolator in the right side of the cabinet, while the left hand platform is being used to hold the receiver. If two such operations are to be conducted at once, or if the left side of the cabinet is required at the same time for another purpose, it may be well to have one of the notched supports (C, Fig. 18) placed on the back of the cabinet, directly in the center. This, then, can be used for receiver A in official manipulations, and the platform on the left side of the cabinet will be clear for other use. Attention is now called to what the writer considers an important improvement in the manner of conducting official percolation. This improvement is made possible and practical by the intervention of the movable platform. As is well known, there are three objections to the usual mode of carrying on percolation according to the Pharmacopoeia. These are : The length of rubber tube required-considering that the same tubing should not be used for many operations, and never the second time for the finer products, unless thoroughly washed and carefully labeled, to be used again on the same class of work-makes this a rather expensive process. Then again, as the receiving bottle must be raised and lowered, a series of blocks are required, which are seldom at hand when needed. The third, and possibly most serious, objection to official percolation, is found in the fact that the 13 rubber tube, where it makes the bend under the percolator, and also over the neck of the receiving bottle (see F and G, Fig. 19*), is apt to bend at an acute angle and shut off the flow of percolate (see H and I, Fig. 20). If this occurs, when unobserved, as sometimes happens, much valuable time may be lost in making the product. If, however, a modification of the usual process is brought into use, as shown in figure 18, all the objections are removed, and it is the writer's humble belief, founded on comparative tests of different methods of percolation, that this is the method par excellence. As will be seen Figs. 18, 19 and 20. by referring to figure 18, the length of rubber tube is much reduced by this method. The hooked glass tube at the end of the rubber tube can be readily hung on the mouth of the receiver, no bend in the rub- ber being required. As the receiving vessel is lowered during the * This drawing represents the arrangement of tubing, etc., as prescribed by the U.S. P., and as shown in text-books on pharmacy as conforming to the Pharmacopoeial requirement. 14 latter part of the operation, the glass rods E and D may be run fur- ther into the tubing H, and in this manner take up the slack. Tubing should be selected which will not fit too tightly over the glass tubes. It is hoped the reader will give this method a practical trial. It will be found that, while the arrangement described fills all the re- quirements of the Pharmacopoeia, and is, in fact, official percolation, it presents advantages over the usual operation, and as the new Pharmacopoeia expressly directs percolation to be pursued in this manner, i. e., with rubber tubing, etc., the method'of manipulating above explained and pictured will be found of much practical value. There is another use to which the cabinet can be put, and for small operations I have found it simple and effective. I refer to distillation and the use of the Eiebig's condenser. This is shown in figure 21, and needs but little explanation. A is, of course, the feeding bottle, into which the liquid to be distilled is placed ; B is the feeding tube, and C the air tube ; D is a tube conducting vapor- ized liquid to the condenser. These three tubes are run through perforated corks, as shown in the drawing. The condensed vapor or distillate is collected as it drops from tube E. The tank bottle F is filled with water-iced is best-and this is fed through the tube G Fig. 21. 15 as slow or fast as needed, the flow being regulated by a screw pinch- cock. The course of the liquids may readily be traced by following the arrows. Direct heat is shown in the drawing, but, of course, sand or water bath may be as readily used, if desired. The orifice H, for admitting a gas tube, is here shown in the side of the cabinet, but, if preferred, it may be made in the back, where it will not dis- figure the fixture. The usefulness of the cabinet has now been, at least partially, reviewed from a laboratory standpoint, but there is one other feature of this invention which attention is here called to ; that is its exhibi- tion or trade-getting feature. As most of us are inclined to the mercenary, are apt to look on the commercial side of things, it may not be altogether unpardonable, in a scientific paper, to refer to the money-getting feature of a laboratory appliance. Aside from the good impressions which improvements in the laboratory or pre- scription department make upon the physician, the displaying of the cabinet in the window, in active operation, would be a most novel and interest-drawing display to the laity, and for the druggist himself, a pleasant relief from the old stock exhibition of chamois, sponges, bird- seed, soap, et al. There are many ways in which the cabinet could be made to do display service to the pleasure and profit of the pharma- cist, which, for want of space, will not be referred to. They will suggest themselves to the bright druggist. If tastefully constructed, the cabinet presents an attractive appearance, and if " a thing of beauty is a joy forever, ' ' this should certainly be a joy " forever and a day, ' ' as it combines with the beautiful that which is useful, and in the useful is found something that is ornamental; it establishes a home for the most necessary and important functions in pharmacy, and greatly assists the tidy druggist, who wishes to have " a place for everything and everything in its place."-Druggists' Circular, December, 1893. 16 Two Valuable Prescriptions for conditions following - La Grippe. These prescriptions have been used with such perfect satisfaction in previous seasons that we take the liberty of offering them here, and suggesting for them a wider use. From reports that have reached us, we can confidently recommend them to our medical friends : Syrupus Acidi Hydriodici (Hostelley's), . f 5iv Liq. Potassii Arsenitis, f3ij M. Sig.: Teaspoonful in water three times daily. (The above will be found useful in the catarrhal conditions accompanying or following La Grippe.) Syrupus Acid Hydriodici (Hostelley's). Syr. Hypophos. Comp., " ^f3ij M. Sig.: Teaspoonful at meal time and on retiring. (The above prescription is in much favor as an "alterative tonic," and is useful after the acute effects of La Grippe have passed.) 17 Hostelley's Hypophosphites. (Syr. Hypophosphites Comp., Hostelley's.) "THE BEST OF THE BEST." Hypophosphite salts, being of a delicate chemical nature, and prone to decomposition when unprotected by II a saccharine vehicle or other good preservative, are seldom found in the market in a condition to produce full therapeutic results. In fact, to secure the entire thera- peutic effects which, under favorable circumstances, these valuable salts are capable of producing, they must be combined with the syrup IMMEDIATELY after preparation. For this reason we manufacture our own Hypophosphite salts, and can therefore vouch for their chemical purity and unimpared condition at time of combination, after which they are fully protected from change by the preservative used. The additional value over ordinary preparations which this fact lends to " Hostelley's " Syrup cannot be overestimated. To establish the correctness of this assertion it is only necessary to observe results. Hostelley's Syrup is the richest in combined salts of any preparation of the Hypophosphites now on the market. This is made possible by the greater solubility of the salts when used AS SOON AS MANUFACTURED. The advantage is apparent, i. e., less syrup is required to secure the usual dose of the remedial agents. The Richest in Salts. Alkaline carbonates are contami- nants frequently-very frequently -found in the Hypophosphites. Examine fifty specimens of the Hypophosphite of Potassium or Sodium salts, and as likely as not forty of them will contain these contami- nants. There could not be present more deleterious agents. They delay and partly destroy the action of the Phosphide Element, upon which the efficacy of the remedy depends, and are also apt to precipitate the compound. In reference to the pernicious effects of alkaline carbonates in the Hypo- phosphites, their author, Dr. Churchill, says: "I had found, by repeated clinical experiments, that when a certain portion of alkaline carbonate was added to the pure Hypophosphites, that their physio- logical and therapeutic effects were manifested but slowly and incompletely, or failed altogether." Eater writers on the subject likewise refer to the evil effects on the Hypo- phosphites of these destructive agents, and they are unquestionably accountable for the non-success of some practitioners in the treatment of various wasting diseases with Hypophosphites. It is scarcely necessary to say that ' ' HOSTEL- LEY'S " SYRUP is free from any trace of alkaline carbonates or other objec- tionable elements. Every physician recognizes the fact that a careful diagnosis is essential to the successful treatment of disease. Is not an intelligently and scientifically prepared remedy a necessary and fitting adjunct? Certainly without such a remedy half the physician's skill counts for nothing. Free from the usual Contaminants. 18 We do not claim that Hostelley's Hypophosphites is "just as good" as any preparation on the market, but superior to any syrup of a like nature. If our product was only "just as good," we would have no excuse for offering it, as the market is flooded with preparations to fill such a field. We sincerely believe it to be the best, and that our belief is shared by a large body of the medical and pharmaceutical professions, its rapidly increasing popularity fully attests. From a contracted field in and about Philadelphia, its use has extended until physicians in almost every State now regularly prescribe it, and a modest export trade has been created. This, too, with but little advertising. MBRIT WINS 1 Not "Just as Good," but Better. The custom indulged in by some manufacturers, and which is to be discouraged, is that of adding citric, tartaric or other acids to the Hypo- phosphites to render them soluble and give the resulting compound a pleasing appearance at the expense of therapeutic worth. It has been shown that preparations treated in this manner undergo a chemical change which destroys, in a measure, the action of the delicate Phosphide Element, and after long standing such a preparation will be found entirely void of the therapeutic properties of the true Hypophosphites. No Destructive Solvents. To fully appreciate the elegance of Hostelley's Compound Syrup Hypophosphites it is necessary to to test it practically. We feel con- fident you will give it the prefer- ence thereafter. To facilitate a trial we will send any physician or pharmacist willing to pay express charges a half pound bottle of the Syrup gratis. That our product may lack no desirable feature, it is put up in bulk as well as in pound bottles. The price is moderate. It will be to your advantage to specify ' ' HOSTELLEY'S '' when prescribing the Compound Hypophosphites. Please Specify Hostelley's. W. H. Hostelley & Co., Manufacturing Chemists, Box 638, Philadelphia. Our preparations are supplied by leading druggists. 19 THERE is a prevalent belief among physicians that Syrup of Hydriodic Acid should always be administered by itself. This opinion is traceable to the fact that most preparations of Hydrogen Iodide are decomposed when in combination with other drugs. This does not apply, however, to Hostelley's Syrup, as will be observed by the following list of combinations, all of which have been thoroughly tested, both from a laboratory and clinical standpoint. They are offered merely as suggestions, and we hope they will be received in the spirit in which they are published. W. H. HOSTELLEY & CO. SOME PRACTICAL FORMULAE. A POWERFUL ALTERATIVE. In those cases characterized by loss of sleep, dimness of vision, poor appetite, tendency to shun society, etc., the following is used with decided advantage : R Diq. Potassii Arsenitis, ..... f5ij Hy drarg. Bichloridi, ...... gr.j Syr. Acidi Hydriodici (Hostelley's), .... fSvj M. Put the bichloride, previously powdered, into the Syrup of Hydriodic Acid, and after reaction has taken place add the arsenic solution. Sig.: Teaspoonful three times daily in water. FOR PERSISTENT COUGH. g Syr. Pruni Verg., . . . . . f3jss Syr. Picis, ....... fSj Syr. Scill® Comp., ...... fSjss Syr. Hypophos. Comp., . -- f... Syr. Acidi Hydriodici, J SA • • . aa 13ij M. Sig.: Teaspoonful three or four times daily. To be given after meals, and in a wineglassful of water. A GOOD GENERAL TONIC-No. 1. g Syr. Hypophos. Comp. (Hostelley's), .... fSiv Tiq. Potassii Arsenitis, ..... f 5ij Bxtractum Malti, ...... f3vj M. Sig.: Teaspoonful before meals. Dilute with wineglassful of water. A GOOD GENERAL TONIC-No. 2. In cases where there is malnutrition, imperfect inervation, etc., the following is recommended: g Strych. Sulph., . . . . . . gr.j Pepsin (scale), ....... 5jss Tinct. Gentian® Comp., { -- f Tinct. Cinchon® Comp.,) ' • ' ' ' J Syrupus Acidi Hydriodici (Hostelley's), .... fSiijss M. Sig.: Teaspoonful before each meal, in water. RHEUMATISM. g Tinct. Cimicifug®, . . . . . . f 3ij Vinum Colchici Sem., ...... fXiss Syrupus Acidi Hydriodici (Hostelley's), . . . fSivss M. Sig.: Teaspoonful in water four times daily. ALTERATIVE TONIC-No. 1. g Quinin® Sulphat., ...... gr. xxx Tinct. Gentian® Comp., ..... f5ij Strychnin® Sulph., . . . . . . gr.j Syrupus Acidi Hydriodici (Hostelleys), . . . f3ij M. Sig.: Teaspoonful in water three times daily. ALTERATIVE TONIC-No. 2. g Acidi Arseniosi, ) -- : Strychnin® Sulphat., J ' ' • ' Tinctura Columbo, ...... f8ij Syrupus Acidi Hydriodici (Hostelley's), . . . f3iv M. Sig.: Teaspoonful in wineglassful of water three times daily, preferably before meals. NERVOUS DEBILITY-No. 1. g Syrupus Hypophos. Comp. (Hostelley's), .... f3iij Tinctura Columbo, ...... f 3ij Uxtractum Zingiber Fid., ) -- Tinctura Cardamomi Comp., f M. Sig.: Teaspoonful three or four times daily. NERVOUS DEBILITY-No. 2. g .Syrupus Hypophos. Comp. (Hostelley's), .... f3iv Tinctura Gentian® Comp., )' -- Elixir Aromaticum, J J M. Sig.: Teaspoonful at mealtime, and on retiring. HOSTELLEY' S Syrup Hypophosphites Comp. PRONOUNCED BY ALL WHO USE IT "The Best of The Best." Hostelley's Syrup represents fresh salts, carefully combined and preserved in a vehicle of glycerin and beet sugar. They are united with the vehicle /IS SOON AS PREPARED, and consequently undergo no chemical change, as is the case when Hypophosphite Salts are bottled and kept for a time before combination. A A ® EbK 1*1 Hmm I l^fiw>ti!ii>w I I J K==r-- -ito* Linr rmriii m1 I || §^-|ggl \ 1 Eg=l v BWb ~ «*»■ I | I ~ 1ima mi " I ) A IRMmmw* ,ob »hu«'* A / i. - jMMgy I ■mihirawi.Mnim"*""*'*. i\ . 1\ /£ ■oz-••!«• »f ■ *eiinuHi -:-f , i\ it / e //S /A MUON Ju ' Spr BOt^ ZzZzZ/Zv, N .yCggS faff A, ,.fwpe*de.v.r J HzzZv2z^7rrS^iiZZ^?^\v^y^V' j - B ''^ORDINARY DOSE | w^~ ip.»■«•.<> -»/*■*>"*' 11 Tg I >\s>» B' . P'snaredby | rv g W.M.iHTOS'FElLlLEY&CO' . ffl vy A VV ife'*"''1' | <zy A\xJ •/\* IMMsiflSt, TJUIJUWLWUL ] </k » KL^IKeep iu a □□□kf'b4CE|o A GOOD PREPARATION of the Hypophosphites represents Phosphorous in its most available form, contributing to the proper development of the osseous structure of the body, and supplying the vitalizing principle so much needed in all wasting diseases. SPECIFY HOSTELLEY'S. As you are constantly ordering Hypophosphites and frequently with- out designating any make, why not specify "Hostelley's" the next time this remedy is required? Much of the disappointment which physicians experience when using Hypophosphites can be traced to an inactive syrup; the salts having probably lost their virtue before combination or their activity being destroyed by improper combining. Specify Hostelley's and note the difference between this and other preparations of a similar nature. PUT UP IN POUNDS, FIVE-PINTS AND GALLONS. W. H. Hostelley <& Co., Supplied by all manufacturing chemists, LEADING DRUGGISTS. LOCK BOX 638, PHILADELPHIA. D. S. WILTBERGER, Special Agent for hostelley's Preparations, 233 North Second St., Philadelphia, Pa.