The Pathologic Impulse to Drink ==Alcohol as a Secondary Factor in Dipsomania. BY WILLIAM LEE HOWARD, M.D. REPRINTED FROM MEDICINE WILLIAM M. WARREN, Publisher February and March, 1898. THE PATHOLOGIC IMPULSE TO DRINK -ALCOHOL AS A SECOND- ARY FACTOR IN DIPSOMANIA. BY WILLIAM LEE HOWARD, M.D., Baltimore, Md. It is to be understood at the commencement that in the present paper the conditions I consider are not to be confounded with those of the common drunkard, the chronic alcoholic, or those found existing in individuals with defective moral sense or continuous unstable mental equilibrium. I shall study in this paper the unfortunate individuals suffering from a pathologic impulse to drink regardless of all effects or results-an impulse considered by many alienists a periodic insanity. The primary condition of the dipsomaniac is not caused by alcohol. The starting-point is a pathologic one; the impulse, the insatiate desire to drink, is due to this pathologic obsession - this paroxysm which has come over an otherwise lucid mind. A clinical picture of one of these dipsomaniacs will enable us to better under- stand the morbid states which we are to study. A man, with wife and children, holding a responsible position, upright and honest in his daily life, shunning coarse companions and avoiding drinking places, educated, refined, and domestic in his habits, who suddenly shows a disposition the very antithesis of his daily life, and after a short interval of abnormal existence returns to his quondam habits, offers an interesting psychologic and pathologic study. The sudden desire, the irresistible impulse, to drink enormous quantities of liquor, concomitant with palsy of the will and moral obmutescence, is rightly called dipsomania. A few days before the irresistible, savage, maddening, overpower- ing impulse to drink exerts its full force, the individual is restless, irritable, suffers from insomnia, or, should he sleep, is disturbed by mild but uncomfortable dreams. Slight muscular tremors may be noticed, and every act is accompanied by an uncertain or impulsive movement, physical as well as mental, showing that though up to this time no alcohol has been taken, and none perhaps for months or years, there exists a slight erethism of the cortex. The struggle, the painful demand for alcohol, the determination to control the crying yearning for some relief from this horrible restlessness, the knowledge of the fact that the higher centers are so disturbed as to make the carrying out of daily duties impossible, are too fearful for even a person perfectly conscious of the ultimate disastrous results to stand against. One drink only will he take to relieve the dis- 2 THE PATHOLOGIC IMPULSE TO DRINK tressing restlessness. He steps into a saloon, an act which a few days ago he would have considered degrading. The one drink is taken, after which there does not appear to be any limit to the amount of alcohol he is capable of consuming. His thirst is savage, uncontrollable, unlimited. Now hours pass as minutes. The indi- vidual becomes voluble, boasting, egotistic, and self-contented; he delivers philippics and enters into polemical discussion with his bar- room companions, considering himself an oracle, the center of every movement. The amount of alcohol imbibed does not affect the motor or sensory centers to any marked extent, but the higher centers are completely in abeyance. No food is taken, and as mid- night comes he departs with his newly made acquaintances to some low, disreputable, all-night hole which is like a palace to him, the parasites being his willing knights. A short doze on a dirty sofa and the morning will find him without the physical or mental energy to leave the rum hole; and humored, flattered, cajoled and contented he will remain in this lycanthropic condition, dirty, filthy, and regardless of his personal appearance, until the nerve storm has spent all its fury. This storm, which approached with its undula- tions of fast-gathering tumults, its psychic murmurs, its sighing, its slow but insidious strength, finally bursts forth in all its horrible- ness and destructive fury, followed by rapid subsidence; leaving the hurtled flotsam, jetsam and moral wreckage to be gathered and dispersed by an interval of normal life. The duration of the storm from its first fitful gusts to its last sigh covers a variable period- generally about three weeks. During this interval but little food is taken, and that at irregular periods. The mental condition during this period is not the one of maudlin drunkenness, not the one of violent, inhuman, tiger-like brutality seen in alcoholic frenzy and pseudo-dipsomania, but one in which the speech is tenuous, light, airy, and teeming with idle gasconade. The ideas expressed are weedy, sedgy, spumy. There seems to be only a slight clouding of the mind as regards surrounding details; the whole mental condi- tion and attitude is in fitting with his companions and environment. He has not the drowsy, sleepy stare of the drunkard; nor does he have the appearance of being insulated in the gloomy umbrage of alcohol. Regarding his true life, his normal condition, there is a hazy, vague state of intellect if his attention is called to it; some- times total oblivion of his duties and responsibilities. The return to his former self is comparatively rapid, and after the recrudescence he will have but a slight recollection of the length of time passed or the places where he has been. Often close questioning and leading THE PATHOLOGIC IMPULSE TO DRINK 3 questions will throw a ray of light on some obscure act, but even then he is not fully convinced that the fact is not some phantasm, some dream, or idle banter of his questioner. He desires no liquor now, and has neither thought nor idea of ever wishing for a drop of alcohol. It is not the moral determination of the drunkard never to drink again, not the sickening, repulsive, abhorrent feeling of the inebriate for alcohol due to temporary excess, but a condition of psychical contentment. Such is a general outline of this patho- logic condition which is demonstrated by the craving for drink. There are naturally many various minor phases of this condi- tion, many clinical units, but they can all be reduced to the same psychical elements. This craze for drink must not be considered a distinct disease, but as a secondary symptomatic condition, as are other impulses in abnormal mental disturbances. Although one attack of dipsomania is generally followed by another, such is not always the case. I have had many opportunities to study these cases throughout their course, having had them under close observation from the prodromic period to convalescence, during which no liquor in any form was given. These cases exhibit a mental disorder character- ized by great depression, anxiety, and restlessness; inability to apply themselves to the simplest reading or games, an indefinable horror of some impending danger, and discoordinated psychic faculties. They soon become indolent and apathetic, though keeping up an incessant walk around the room and a conversation consisting mostly of lamentations regarding their inability to ever return to their business or profession. Insomnia is persistent, and anorexia so pronounced that often the taste of food will bring on an attack of vomiting. There is often spasmodic gulping down of food, and unsuccessful attempts to swallow, exhibiting an aura as character- istic as the epileptic aura. Frequently the sensation of precordial anxiety will be observed. In a day or so comes the impulsive, uncontrollable desire for drink. Large draughts of water are taken -hot one minute and a vehement demand for cold the next. The relief is only temporary, and soon the demand for alcohol asserts itself in pleading, cursing, and argumentation, sometimes ending in a frenzy-the delire emotif of Morel. During this period, which will last several days, the throat is parched, the skin hot and dry. The pulse varies from 85 to 100. Although large quantities of water are consumed, comparatively little urine is voided, and that is heavily charged with phosphates. At the height of the attack there is a passionate, desperate demand for alcohol - alcohol in any form. THE PATHOLOGIC IMPULSE TO DRINK 4 They plead, clamor, pray and struggle until, exhausted, they sink into a temporary consciousness of the impotency of their will and mental demoralization. This condition lasts for a short time, when the craze for alcohol again commences. With the subsidence of the cortical irritation comes great physical weakness and moral depres- sion, or the oppression of inexpiable guilt, apparently much greater than in the cases which have succumbed to the passionate demand for alcohol. In fact the latter cases recover their physical health in a few days; the former suffer from weakness and mental depression for some weeks after. This mental depression is probably due to a better recollection of the sad state they have been in and the fear and anxiety of future attacks (jnelancolie imptilsive ou anxieuse}. The cases which yield to the impulsive demand for alcohol are little troubled by introspection, as the alcohol has paralyzed the higher centers and the memory of events is too vague and hazy to give these individuals those afflicting, dismal thoughts which cause so great apprehensiveness to the cases which go through the attacks without obtaining alcohol. The cases under strict surveillance and not allowed to have any alcohol last much longer than do those who exhaust themselves by excesses. In these latter cases the abatement of the cortical irritation takes place more rapidly. There is no demand, desire, or physiologic craving for alcohol in these subjects when the nerve storm is over. Alcohol in any form is repugnant to them-a radical difference from the inebriate or drunk- ard. There are few if any symptoms of alcoholism. Of all the phenomena of which the life of the neurotic is replete, this one of dipsomania requires conscientious study by the medical profession. It is not an isolated phenomenon, but a syndrome. Its force, fury, sudden onslaught and periodicity demonstrate that we are dealing with a mental disturbance. For the sake of humanity, science and sociology we should do our utmost to bring it out from the dark chaos in which it is confounded with vicious habits and drunkenness, and place it among those psychoses which the science of medicine studies and treats as mental and nervous diseases. Too great importance has been attached to the alcohol habit in connection with dipsomania. Alcoholism never leads to true dipso- mania, although alcoholism and pseudo-dipsomania are allied, and the error has arisen in confounding the latter with dipsomania. The line between the drunkard and the pseudo-dipsomaniac is not an incised one, the conditions being those of correlation. The pseudo - dipsomaniac is an intermittent drunkard. He will drink to excess whenever opportunity occurs, and at no time does he have THE PATHOLOGIC IMPULSE TO DRINK 5 that repugnance for or fear of alcohol which possesses the dipso- maniac during his lucid intervals. The pseudo - dipsomaniac will enjoy an opportunity to drink to excess, but ceases with the oppor- tunity. The dipsomaniac knows no halt, no restriction; he must, he will, he does, succumb to the impulse to drink to the extent of causing total oblivion of all honor, respect and fealty due himself, and all duties, obligations and responsibilities due others. It was this confounding of dipsomania with pseudo-dipsomania that caused Hutcheson, Bucknill, Hack Tuke and others to divide dipsomania into several varieties. That which distinguishes dipsomania from various alcoholic hab- its and conditions is the impulse. Its periodicity causes Kraft- Ebing to consider it a periodical insanity, a variety of hereditary alienation. Magnan admits that the impulse is a syndrome met with in individuals with a hereditary incubus (les syndromes de la folie des hereditaires). It is evident from what has been said that the victim of dipso- mania is born with defective mental equilibrium; that this unstable- ness is a profound one, and increases from infancy to full growth, and exists throughout the life of the individual. Rabid impulsiveness is a phenomenon demonstrating peculiar mental states. This impulsiveness may take various forms and phases, but whatever its form it diminishes organic and psychic resistance. (Second Paper.) The aim of all scientific research is to understand cause and effect. No one individual can grasp more than a general idea of the widely diversified scientific thoughts and movements to-day. But few of us succeed in even getting a general view of the ever- changing phases of single special branches. The effective power of scientific research depends upon the subdivision of labor; the mutual dependence of any subdivision upon the others, and a har- monious and truthful relation among all. In my last paper I considered and described the condition of individuals suffering from the periodic craving for alcohol - a symptom - complex known as dipsomania. Whether we consider this hyperkinesia as a periodic insanity or as a latent unstable equilibrium of the cells of the cortex aroused by peculiar environment, fatigue, or by one of the numerous rhythms which are continually taking place in the central nervous system, or, as I believe it is sometimes, due to autointoxication, the effects and ultimate results vary but little. 6 THE PATHOLOGIC IMPULSE TO DRINK Berkley,1 Andriezen,2 Bevan Lewis3 and others have given us excellent reports on the conditions existing and changes taking place in the cortical and central cells of individuals suffering from acute and chronic alcoholism. These studies have been useful as far as they go; but what is needed is a thorough understanding of the conditions existing in the central nervous system which cause certain individuals to have an uncontrollable impulse for alcohol- the condition prior to any alcoholic indulgence. I admit that to attempt any such studies appears rather fatuous, from the obvious difficulties which arise. There are various hypotheses, speculations and provisional statements put forward to account for the periodic attacks of dip- somania-statements referring to heredity, environment, predisposi- tion, the inability to control impulses, and many other vague and unsatisfactory reasons. That there is always a morbid weakness of control is evident. There is also the fact of transformed modes of nervous energy temporarily bursting the bonds of the individual's will; and the function of the brain, the mind, temporarily loses its normal mediating power. Bad social conditions, unfavorable envi- ronments, a predisposition for alcohol through heredity, faulty training and neglect of moral education, will cause lawlessness, drunkenness, and its concomitant vices; but aside from the vexed question of heredity, we have none of these conditions existing as the cause of true dipsomania, but only as the effect during the attack. The unfortunate victims of this form of hyperkinesia are generally those whose surroundings are of the best, individuals of genial and honest natures, educated, bright, and highly intellectual; many have been the most brilliant of their time. Hence we must seek for some inherent cause in the nervous system which produces this unfortunate rhythm in an individual otherwise normal in all his acts. Dipsomania is a symptom of defective inhibition. Defective inhibition may show itself in multitudinous forms of impulsive acts - from slight exhibition of temper to atrocious crimes. As the majority of individuals suffering from attacks of dipsomania are those who live at a high nervous and mental pressure-physicians, lawyers, litterateurs, and business men-exhaustion of nervous energy is frequent and often continuous, and the reserve brain power is soon used up. Exhaustion of nervous energy always lessens the inhibi- tion. The cells of the cortex become exhausted by long and 1 Johns Hopkins Hospital Reports, vol. vi, 1897. 2 Brain, 1894. s Text-book of Mental Diseases, p. 528. THE PATHOLOGIC IMPULSE TO DRINK 7 continued expenditure of energy; the individual resorts to alcohol to relieve his uneasiness, his restlessness, the result of this cell exhaus- tion, and which prevents him from attending to his ever-pressing duties. It is then that the defective inhibition is shown, and the uncontrollable impulse breaks the bounds of reason and judgment. What the pathologic condition of the cells is in these unfortunates is unknown. I consider it analogous to the hypothetic pathology of hysteria.1 That there is a physiologic similitude between the mild hysteric attacks of a woman who tries to control her actions, but is not able to do so, and the impulse to drink, which the dipsomaniac is aware of, but generally tries to resist, seems evident to me. The protoplasm of the cells of the cortex becomes used up by continued work without the necessary rest needed for recuperation, and while in this vacuolated state they are unable to function their parts; a small amount of alcohol rapidly cuts the higher centers off from the lower, and the result is a disorganized condition of the general nervous system in which the inhibitory power is lost, normal volitional potentialities reduced to mere atoms, and impulsive acts directed by the stimulation of the lower centers. Starting with such conditions it leads one to the hypothesis that a continuance of these would result in some organic changes, or at least in such changes that each attack leaves the connection between the higher and lower centers less active, with a lessened amount of functional force in the cortical cells, all of which changes are exhibited in the force, fre- quency and duration of dipsomaniacal attacks. Some cases of dipsomania can be directly traced to the absence of early education in not correcting uncontrollable impulses in early childhood, but even here we will invariably find the child has inher- ited a richly neurotic soil; demonstrated by uncontrollable impulsive acts. In some cases there seems to be an interruption of develop- ment in certain centers, as is demonstrated by these impulsive acts of childhood. This condition must be understood when training or correcting the child. As Donaldson2 aptly puts it: "No amount of cultivation will give good growth where the nerve cells are few and ill nourished, but careful culture can do much where there are those with strong inherent impulses towards development.'' The following case well illustrates the disastrous results following the neglect to develop the cells of the higher centers by careful and intelligent training and instruction: A patient, aged 40, was referred to me last year by his family 1 Hysteria and Allied Conditions, Preston, 1897. 2 Donaldson: The Growth of the Brain; London, New York, 1896. 8 77/A PATHOLOGIC IMPULSE TO DRINK physician. His social position was of the best; and in his lucid intervals, which generally covered a period of four or five months, his environments were those of cultivation and refinement. During his attacks he was an individual of the type described in my last paper. In childhood he was wilful, disobedient, and exhibited a temper beyond all self-control. His mother told me that so furious would he become over trivial matters that his screaming and violent actions would frequently terminate in epistaxis. In one of these outbreaks he attempted to stab his mother with a carving knife. He would drive the servants out of the house as he grew older, by his violent threats and uncontrollable temper. Ordinary mild per- suasion and admonition had no effect on him, and thus he grew up with defective inhibitory power. He developed extraordinary busi- ness capacity, and rapidly rose to prominence in business matters. When about 25 years of age the defective inhibition began to show itself in dipsomaniacal attacks, which, on account of his value as a business man, were overlooked for years, until they became so fre- quent and prolonged as to make him useless in any capacity. His mother is a neurotic, and displays slight defective inhibitory powers. One sister I strongly suspect of being addicted to the morphine habit; a brother is a "ne'er-do-well," an aunt died insane, while a grandfather on his mother's side was a steady drinker. While in' this case we have a history of a neurotic soil, I believe that had his training been such as to have compelled him to control his morbid impulsiveness, or in other words, had the early signs of his defective inhibition been recognized and corrected, we should now have a valuable member of society, instead of what his acquaint- ances consider a degenerate. There is no degeneracy in such cases. The condition is simply one of inherited defective inhibition, which can, in most cases, if early recognized, be greatly modified if not corrected. As pointed out by Crandall,1 heredity and degen- eration are two totally different phenomena. One is an inheritance of tendencies or qualities possessed by the ancestors; the other is a loss of those qualities. The one produces a condition similar to that of the progenitor; the other, a condition dissimilar. The one is always transmitted; the other may be transmitted or acquired. The victim of dipsomania, like the sexual pervert,2 is one gen- erally born of ancestors whose central nervous systems have been on an exhaustive strain throughout life. Many men in this country, in the last decade, have not married until they have rushed through 1 Archives of Pediatrics, December, 1897. 2 William Lee Howard: Psychical Hermaphroditism, Alienist and Neurologist. April, 1897. THE PATHOLOGIC IMPULSE TO DRINK 9 the best portion of their life in the hurry, push and excitement of an early business or professional career. They bequeath to their progeny the dregs of a former vital and equilibriated cell proto- plasm, and the natural result is an unstable nervous mechanism which the heir is unable to adjust. In these cases the law of heredity prevails, but between the laws which are to act and the indefinite variety of forces and circum- stances upon which those laws may operate is a vast stretch of uncertainty. There is another large class of dipsomaniacs whose history shows the early disturbance of the cortical cells (in using the word cell I refer also to its appendages) during their developmental periods. These are the cases which in infancy have been given by " the old nurse" alcohol in some form. If one carefully investigates he will be surprised to learn what a large number of individuals were early quieted by doses of gin and brandy. I have one case on hand with a history of gin being given to him daily from birth up to the age of two years. I am not referring to the low, ignorant class among whom this habit is not unusual, but of a class which consent and courtesy calls intellectual. In these cases it is not surprising that we find an absence of harmony and lacunae of function rhythmically appearing when cell fatigue has exhausted all reserved force. That these conditions may exhibit it in phases of the various neuroses other than dipsomania is evident; but I am now only speaking of some of the causes of this particular symptom of defective inhibition which shows itself in the impulsive action to drink alcohol in any form and regardless of the consequences. I have referred to the favorable social conditions generally sur- rounding the victims of dipsomania. It is necessary to accentuate this factor so as to bring out more distinctly the neurotic origin of this symptom-complex. As Donaldson1 says: ''The central nervous system, whatever its natural perfection, must be extremely respon- sive to surrounding social conditions, and thus growth processes in it be modifiable in no small degree, hence the conditions which social states imply." Among the other causes producing this dynamic disturbance of the central nervous system is autointoxication. As this is a subject by itself I merely mention it here. A peculiar condition sometimes met with is the coexistence of chronic alcoholism and dipsomania. Generally such cases terminate rapidly. What original inherent strength the brain had is soon 1 Op. cit. 10 THE PATHOLOGIC IMPULSE TO DRINK weakened by disease or tissue degeneration due to the chronic alcoholism, and a few dipsomaniacal attacks cut off the individual in early life. In these cases we generally find a true dysthymia, and the end is often by suicide. Two cases in my practise terminated in this manner last year. In taking up the subject of prophylaxis and cure we must con- stantly bear in mind the somatic cycles by which many of our unconscious actions are governed. These physiologic rhythms are habits of organic activity. I believe that the long rhythms in nutri- tion and heat regulations of the body are factors in augmenting and aggravating the periodicity of dipsomania. Under pathologic con- ditions such as hypothetically exist in this psychic explosion, its intervals appear to be governed by the organic cycles, including the monthly rhythm of the female with its concomitant changes,1 and which in this sex, at this time, is often marked by slight attacks of dipsomania. It is evident from what has been said about the uncontrollable impulses of childhood that the prevention of these analogous attacks in adults is in the early training of the child, and a thorough under- standing of the heredity of the child. When physicians and parents fully realize the meaning and ultimate disastrous results of the passionate, paroxysmal, and violent outbreaks, a veritable faire le diable a quatre, then will many an individual bless the day that he was compelled to control the outbreaks and by such training throughout the developmental stage reach manhood with a nervous system work- ing in harmony the balance of his life, and able to adjust itself to the various circumstances and rhythms as they occur. If we have cells controlling inhibition they are dormant in the cases where the child shows uncontrollable impulses. Education cannot cause any fundamental changes in these cells, but it can vastly strengthen them. In all functional activities a tendency to the formation of habit occurs, and it makes all the difference between happiness and sorrow when by habit we rouse these dor- mant cells into constant activity. The treatment of dipsomania offers such a perplexing chaos of conditions to deal with that I approach the subject with hesitancy. The result of studious, laborious and earnest work on one of these cases may result in such complete failure as to cause the general practitioner to consider them hopeless, and often to ignore or refuse to treat them. Only a short time ago a young man came to me with pleading aspect and anxious appearance and all the other psychic 1 Havelock Ellis: Man and Woman, London, 1894. THE PATHOLOGIC IMPULSE TO DRINK 11 and somatic appearances of an approaching attack of dipsomania. He had been to his old family physician, who gave him the sound advice not to take a drink, not realizing for a moment that the young man needed intelligent and immediate assistance to follow this advice. The conditions existing in dipsomania are so different from those in inebriety that confinement in an institution offers many difficult problems. It is impossible in the early years of the dipsomaniac to foretell the time and frequency of an attack. The individual may go for a year or more without any symptoms of the dangerous psychic mine hidden in the soma, or give any indications when that mine will explode. The best we can do is, after getting a complete history, past and present, of the case, to educate the dormant cells, and as closely as possible correct the defective inhibition. Sugges- tion, with or without hypnosis, is of considerable value at this point. Everything possible must be done to prevent the exhaustion of nerve force, and efforts made to store up reserve material. The physiologic rhythms must be watched, and when we see the approach of the ebb of these rhythms the patient must be care- fully guarded. The rhythm which is particularly apt to be danger- ous is the daily one occurring in the afternoon about three o'clock, although there is one occurring about eight in the evening which also needs to be remembered. It is at these hours that I have my patients come to me, giving them an hour or two rest, through sug- gestion, thus tiding over an anxious and perilous period, while also allowing the necessary recuperation of the cells of the central sys- tem. Success greatly depends upon aborting a few attacks. The patient feels greater confidence, sees hope ahead, strives with strengthened desires, and anxiety is lessened - all of which con- tributes to the ultimate psychic result needed, control over morbid impulses. It is not desirable to keep these patients restricted or confined; they require the mental work and exercise of their daily vocations, and the idea of daily treatment is to compel them to give the cells of the central system a much needed rest, which they would not get, or be incapable of getting, without the moral and material assistance given them by one whose heart and mind is devoted to these unfortunate and much misunderstood victims of this fin-de- siecle period.1 Strychnine is of great value in these cases if used in large doses and for a long period. It is surprising how tolerant these cases are to strychnine. I often give one-twentieth of a grain 1 Wm. Lee Howard: Alcoholic Maniacal Epilepsy, Quarterly Journal of Inebriety, July, 1897. 12 THE PATHOLOGIC IMPULSE TO DRINK hypodermically every two hours during waking hours, while the restlessness, the mental irritation and the other prominent signs of an approaching attack continue. I prefer the nitrate of strychnine, and keep my patients on it for two years or more. During an attack of dipsomania strychnine should not be given. When the normal mental condition begins to return it may be used in small doses, as the object is to keep the cerebellum as quiescent as pos- sible; hence considerable judgment must be used at this period in giving strychnine. Under no circumstances should chloral be used at any stage in dipsomania. Chloral lessens the inhibitory power of the brain. It is scarcely necessary to more than mention the fact that all the rational methods used in functional neuroses must at one time or another be utilized as adjuncts in the treatment. The diet calls for careful supervision and judgment. The amount of proteids must be regulated, for it should not be overlooked that an exclusive proteid diet causes the formation of excessively large quantities of soluble peptones and albumoses, which have an excit- ing action on the nervous system and constitutes a favorable basis for the development of the multitudinous neuroses. There are several important and interesting medico-legal ques- tions to be considered in dealing with uncontrollable impulses. Rigid lines should be drawn for the courts to recognize between the responsibility for acts committed by the inebriate and those com- mitted by the dipsomaniac. It is to be hoped that teachers, parents and physicians will per- ceive in the child the basis for a useful or useless life according to the understanding of the heredity, and thus prevent an increase of uncontrollable impulse which so often leads to the distressing and ruinous neurotic disease, dipsomania. MEDICINE * * ♦ EDITOR-IN-CHIEF: - HAROLD N. MOYER, M.D., Adjunct Professor of Medicine, Rush Medical College; Neurologist to the Cook County Hospital, Chicago. ♦ * ♦ DEPARTMENT EDITORS: Medicine: James B. Merrick, A.B., M.B., Adjunct Professor of Medicine, Rush Medical College; Attending Physician to Cook County Hospital, Chicago; and Bertram W. Sippy, M.D., Professor of Medicine in the Chicago Post-Graduate School. Surgery: Weller Van Hook, A.B., M.B., Professor of Surgery in the Northwestern University Medical School and in the Chicago Policlinic; Surgeon to the German Hospital. Pathology and Bacteriology: Arthur R. Edwards, A.M., M.B., Professor of Therapeutics, Northwestern University Medical School; Professor of Practise of Medicine and Clinical Medicine, Northwestern University Woman's Medical School; Attending Physician to Cook County and St. Luke's Hospitals; Pathologist to Wesley Hospital. Therapeutics: N. S. 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Baum, M.D., Professor of Dermatology and Syphilology in the Post-Graduate Medical School, Chicago; Fellow of the Chicago Academy of Medicine. Ophthalmology: C. P. Pinckard, A. B., M. B., Professor of Ophthalmology, Chicago Post-Graduate Medical School; Attending Ophthalmologist, Michael Reese Dispensary, Genito-Urinary Biseases: G. Frank Lydston, M.B., Professor of Surgical Diseases of the Genito-Urinary Organs and Syphilology in the Chicago College of Physicians and Surgeons. Climatology and Public Health: Norman Bridge, M.B., Los Angeles, Cal., Professor of Clinical Medicine and Physical Diagnosis, Rush Medical College; and Joseph M. King, M.B., Los Angeles, Cal. Forensic Medicine: M. B. Ewell, M.B., LL.B., Dean of the Kent College of Law, Chicago. We are endeavoring to place before physicians a journal that shall contain strictly scientific matter, equally interesting to members of the profession in all parts of the country. All matters of a personal or con- troversial kind are excluded; also society news, and items of local impor- tance only. MEDICINE shall be kept abreast of the times, but matters which, as yet, do not admit of an authoritative opinion will not be ex- tensively considered. HAROLD N. MOYER, M.D., Editor.