Summer Complaint: A Clinical Contribution to the 2Eti- ology, Pathology, and Treatment of the Disease. /BY H. ILLOWAY, M. D., Lecturer on Diseases of Children, Cincinnati College of Medicine and Surgery. REPRINTED FROM THE Neto York fHetocal journal. Reprinted from the New York Medical Journal. SUMMER COMPLAINT: A CLINICAL CONTRIBUTION TO THE ETIOLOGY, PATHOLOGY, AND TREATMENT OF THE DISEASE. By II. ILLOWAY, M. D., LECTURER ON DISEASES OF CHILDREN, CINCINNATI COLLEGE OF MEDICINE AND SURGERY. Despite all that has been written of late years upon this subject, our knowledge of the intimate nature of this mala- dy, the great scourge of infantile life, has not made great progress, and the treatment being therefore vacillating and uncertain, directed now to one special symptom, now to an- other, is not attended by any greater success, as is clearly shown by the mortality statistics of our health offices, than it was formerly. I use the term " summer complaint " as I know of no other more applicable, and certainly none that would better indicate the nature of the malady and the therapeutic meas- ures necessary for its relief. I hold this disease to be a morbid entity entirely dis- tinct from the gastro-intestinal catarrhs produced by errors in feeding or diet or by toxic agents developed in the food, and most certainly distinct from cholera infantum, a term so frequently applied to it. In order that the subject of this paper may be still more Copyright, 1892, by D. Appleton and Company. 2 SUMMER COMPLAINT. clearly defined, a symptomatic description is here appended at the outset: " A malady of the infantile period of life, a disease essentially of hand-fed children, affecting more espe- cially those passing through their second summer." It is a disease that prevails more particularly among the poorer class-those living in crowded tenement-houses and in close, badly aired apartments. It usually makes its ap- pearance with the first days of July, though sometimes with the middle of June if that month be already very hot, as has happened in the last few years, and lasts until the early part of September, when, the nights having become cool, it rapidly disappears. Symptoms.-The symptoms of this malady are restless- ness, vomiting, diarrhrea, fever, emaciation. (a) Restlessness.-After two or three hot days and nights the infant, which previously had slept well, becomes rest- less. The sleep is fitful and disturbed; there are frequent paroxysms of crying, these crying spells lasting from ten minutes to half an hour and even longer. The child is peevish; wants to be carried around on the arm; it will not rest in the cradle or bed. This restlessness, which is most marked at night, is also present in the day-time. When, however, the infant is taken out in the wagon or upon the arm into the cool morning air, or, if it be night, into some open space where the breeze has free play, it will sleep a nice, pleasant, quiet sleep that may continue unin- terrupted for hours. As soon, however, as it is taken back into the house the restlessness and peevishness return. With the increase in severity of the malady the restless- ness increases. The infant gets but very little sleep, and only then, as already mentioned above, when out in the open air, or when under the influence of whisky or of some hypnotic. It will not stay in the cradle or bed; wants to be carried upon the arm continually; will cry for hours, till SUMMER COMPLAINT. 3 exhaustion compels it to stop. It kicks its legs, moves its body, rolls its head. This restlessness is generally greatest at night. (6) Vomiting.-After a restless night or two, as already described, it will be observed that the child does not feed naturally; it will either not take all of its bottle or it will drink it down very greedily as if it had great thirst. After feeding, eructations of wind or sour-smelling material are apt to occur; or, if the food has been taken very greedily and hastily, some of it, perhaps the larger part, may be vomited. With the continuance of the conditions produc- ing these phenomena the vomiting becomes more frequent, until, when the malady has reached its climax, nothing at all in the form of food will be retained upon the stomach ; it will be ejected almost as soon as taken. With the increase in the frequency of the vomiting there is also an increase of thirst and of hunger, and the infant will take its bottle or its drink greedily only to eject again what it has taken. The great thirst is one of the marked features of the malady. (c) Diarrhoea.-With the setting in of the restlessness and of the vomiting there occurs also an increase in the number of the stools. At the outset there may not be more than three to six stools in the twenty-four hours ; at a little later period they may go up to ten, and at the climax to fifteen to twenty in the same period of time. At first they are semi-solid, homogeneous, yellow in color, and neutral in reaction; then they become more liquid in consistence, green in color, and acid in reaction. Or they may be semi-fluid, heterogeneous, and green, with fragments of yellowish-white casein, and acid in reaction ; or quite watery, with numerous flakes of yellowish or green- ish matter, and acid in reaction. Or the stool may contain a large quantity of mucus mixed up with the greenish or 4 SUMMER COMPLAINT. yellowish matter, almost like that of a mucous diarrhoea. Or it may be entirely white in character, like a deposit of casein coagulated in small lumps, as if the casein had been expelled from the intestines just as it had come from the stomach, without undergoing any change in them. Usually there is considerable mucus mixed in with the lumps of casein. Sometimes the stool is half white and half green. The character of the stools is not constant, changing from day to day; and this inconstancy is marked from the outset of the disease. Nevertheless, it is considerably de- pendent upon the food that is administered. Thus the white or half-white stool mentioned above is only observed in children fed with cows' milk that has undergone no other preparation than boiling and dilution with water. The odor of the stools is at first faecal, then it may be either acid or sour-smelling, or offensive and putrid. Or we may have the three odors in the following order: First, the ordinary faecal; then the sour-smelling; and, last, the offensive or putrid. Occasionally we also find a moldy or musty odor. The putrid stool is alkaline in reaction. The act of defecation is preceded by pain, manifested by the expression of the face, by crying, by twisting of the trunk, and drawing up of the legs. When this diarrhoea has continued for any length of time there may be tenes- mus, and there is very frequently prolapse of the rectum with the stool. Under these circumstances a minute quan- tity of blood in the shape of a bright, red streak will be noted in the stool. Sometimes great exhaustion follows it, and the child will lie back on the arm or on its bed with its face pale and eyes closed and very near to a syncope. The abdomen is distended with flatus. Undoubtedly this is the source of the frequent colicky attacks observed. Tenderness of the abdomen I have never noted. SUMMER COMPLAINT. 5 (d) Pyrexia.-With the setting in of the restlessness it will be found that the hands of the infant are warmer than usual, but the increase of temperature is especially well marked on the head, over the verto-occipital region, which is hot to the touch. A thermometer placed in the axilla will indicate an increase of from 2° to 3°. Usually the highest temperature is noted at the outset, and sometimes also just before death. This increase of temperature con- tinues throughout the whole period of the disease, with variations therein. However, when the diarrhoea becomes very profuse and the exhaustion thereupon marked, the temperature may fall to, and even below, the normal. It is a rather noteworthy feature that even then yet the head does in many cases feel hot, or at least warmer than natu- ral, to the hand applied to it. The pulse is increased in rapidity, beating 130 to 150 per minute. It is weak. (e) Emaciation.-It is one of the noteworthy features of the malady that emaciation sets in very early and may reach an extreme degree. And it is but natural, as, from the fre- quent vomiting and the diarrhoea, but very little food is carried into the system to supply the deficit. The face be- comes pale; the eyes are surrounded by dark circles; the nasal lines appear; the fontanelle is depressed. The fat disappears from the body; the muscles grow soft and flabby. This diminution of the fat continues until the in- fant is a mere skeleton. Its face then presents a peculiar appearance-an appearance characteristic of the disease : the face of advanced old age. The skin is dry and wrinkled. The buttocks and inner surfaces of the thighs are reddened by the acid stools and concentrated urine. There is great feebleness and languor, but the voice usually maintains its vigor up to a late period; and an infant too feeble to hold up its head will cry lustily for a considerable time at a 6 SUMMER COMPLAINT. stretch. Toward the end of the malady, when the drain upon the system has almost completely exhausted the vital forces, the voice becomes weak and piping. The urine, as might be expected, is diminished in quan- tity and passed only three to four times daily ; frequently at longer intervals-as much as twelve hours. It is a noticeable feature that with a remission of the heat-i. e., with a little fall in temperature, with a little cooling of the atmosphere, as occasionally occurs during the summer-all the symptoms ameliorate and the infant ap- pears much better, only to relapse again with the next rise in temperature. When death approaches, all the phenomena are usually exaggerated: the pyrexia is greater; the restlessness is greater, the infant rolling around and moaning and emit- ting, occasionally, shrill cries; the vomiting is incessant; that is, everything administered by the mouth is imme- diately ejected. The discharges from the bowels are either entirely arrested or passing involuntarily, and small in quan- tity, almost continually. There is frequently strabismus; if not that, indolent pupils. Occasionally convulsions set in shortly before death. Sometimes the phenomena are just the reverse : A sub- normal temperature ; a cool skin ; a dull, drowsy state verg- ing on stupor; an apathetic refusal of food and drink; a cessation of vomiting, even though a little drink, as of cool water, be put into the mouth and swallowed; arrest of diar- rhoea ; coldness of the extremities. When the malady tends to recovery, the vomiting stops -that is, food and drink begin to be retained; the stools decrease in number and become more normal in character and appearance ; the fever disappears; the skin becomes moist; the restlessness grows less pronounced and disap- pears and the sleep thus becomes sound, uninterrupted, and SUMMER COMPLAINT. 7 refreshing. The eyes grow brighter, and the infant be- gins to manifest interest in its surroundings. It takes its food better and rapidly regains flesh and strength. Micturition becomes more frequent, more in accordance with the normal state; the urine normal in quantity and character. Summer complaint is a disease of comparatively long duration, lasting from four to six weeks, and I have seen cases that have lasted eight weeks.* This applies more particularly to hand-fed infants. Infants nursed at the breast-and these are but very rarely attacked-generally, if appropriate measures are instituted, quickly recover. Death is most frequently due to the extreme exhaustion of the vital forces, f There is one special feature of this disease which, though rarely observed, merits some attention here, as but few text-books make mention of the same. This feature is a peculiar exanthem which makes its appearance usually at a late period in the disease. Small, roseola-like spots appear upon the arms, upon the legs, or upon the whole body, and it looks very much as if the child were going to have an attack of measles. When very abundant, it is very likely to be mistaken for measles by the laity, and the poor little patient, who is already burning with fever and consumed with thirst, is swathed in heavy flannels and dosed with warm saffron tea J until either compassionate Death relieves him or the intelligent physician saves him from further torture. The spots remain isolated, or not more than three coalesce. The skin between them retains * See report of eases further on. f See Diseases of Children, by J. Lewis Smith, edit. 1890. Dis- eases of Digestive Organs in Children, by Louis Starr, 1886. | This is no exaggeration; it happened in a case under my obser- vation. 8 SUMMER COMPLAINT its normal color. The eruption lasts from two to five days, gradually paling in that period, and then disappears with- out desquamation. The very few instances in which I ob- served this exanthem were cases of summer complaint that had either not been treated at all or only indifferently up to the period of eruption. Baginski * says that in the few cases in which he observed the exanthem it was not of bad import; in the cases under my observation it heralded a fatal issue. Occasionally, and still more rarely, another form of ex- anthem is observed. This, as Baginski f rightly observes, can hardly be called anything but an erythema multiforma. It appears in the form of pale or bright-red patches, of greater or lesser extent, and with more or less infiltration of the cutis. This also disappears in a few days. In the years 1871, 1872, 1873, 1874, and 1875, while connected with a colleague in medical practice in a tene- ment-house quarter of this city, I had occasion to see many cases of thij disease during the summer months of each year. From the setting in of the hot weather it was noth- ing but summer complaint day after day, almost ad nau- seam. In the course of this large experience I had occasion to try almost every method of treatment recommended and every remedy that up to that time had been advised : bis- muth, chalk, oxide of zinc, calomel, hydrargyrum cum creta, pepsin, lactopeptin, tannic acid, haematoxylon, opiates, vari- ous kinds of infant foods, the raw-beef treatment imported from Russia and so highly lauded by Trousseau. The results of all and the several methods were mostly nil. The children whose parents were not of the poorest, * Berliner klin. Wochenschrift, 1889. No. 49. f Ibid. SUMMER COMPLAINT. 9 whose habitations were not of the worst, and who had suffi- cient vital powers to carry them through the long siege, dragged through a miserable existence until the setting in of the cooler nights, when the disease began to abate, and the infant that had been worn down to skin and bone gradu- ally revived, gained in vigor, and lived, while those not so endowed died, despite all and everything that was done for them. This experience was further verified by the obser- vations made, though not in such numbers, in subsequent years. In view of this unsuccess in treatment with all the remedies at command, even with such as had been heralded at one time or another as veritable specifics; in view of the fearful mortality attendant upon this disease, it became evi- dent to me that the nature of the malady was not yet at all understood, that the supposed pathology of the disease, as taught by post-mortem section, was erroneous, and hence this failure. This conclusion arrived at, I began the study of the subject anew. With this purpose in view, I carefully re- viewed the mass of notes taken and the histories of cases kept during the past years. From a careful collation of these, the following facts stood forth prominently : a. Nursing infants may be attacked by the malady. b. That even in families where the most scrupulous care was exercised as to feeding, bottles, and milk, such cases would occur. c. That infants were affected who received no milk at all, but were fed with different kinds of infant food. d. That even the most restless and sleepless child in the house became quiet and slept when kept out in the open air. I have seen mothers keep their little patients out till two and three in the morning. e. That the infants that were quiet and slept while out in 10 SUMMER COMPLAINT. the street (that is, in the parks and open spaces, away from the large brick houses) would be but a short time in the house when they again became restless, noisy, and fretful, and had to be carried around upon the arm until morning, when, usually from sheer exhaustion, they would fall into a short, fitful slumber. f. That the infants that vomited and purged at short intervals in the house would, while out in the street (in the open places above described), be able to retain food and have rest from the diarrhoea for as much as three to four hours and even longer. As soon as they returned to the house, or rather a short time thereafter, the vomiting and diarrhoea recurred with their previous frequency. To these points I added the already well-established facts laid down in all text-books and corroborated by my notes : 1. That this disease always prevailed at one and the same season-to wit, the hot months of the year. 2. That it was chiefly among the tenement-house popu- lation that lives in apartments that are hot and stuffy and which are still further heated by the cooking, washing, ironing, etc., and by the burning of lamps at night, that the disease manifested itself. A careful consideration and weighing of all these facts- and they are facts that will be verified by all who have Irad sufficient opportunity for observation in the homes of the people-led me to the inevitable conclusion that heat was the principal, if not the sole, factor in the Aetiology of this malady. The therapeutic indication, the logical sequence of such a conclusion, was clearly this: that we must address our- selves to the modification of the aetiological factor, heat or its effects, if we desired success for our therapeutic inter- vention-remotus causa tollitur effectus. But how to do SUMMER COMPLAINT. 11 this ? It is true that I might have advised removal to the country, to the mountains, to the sea-shore; but, unfortu- nately, it is mainly those, as already said, who do not pos- sess the necessary means to get away whose children are thus afflicted. I determined, therefore, as 1 could not change the temperature, to resort to such a measure as would do for the time being what is accomplished by removal to the country, to the mountains, or sea-shore-i. e., remove the child from the heated atmosphere, and at the same time re- move any effects already produced by it-a measure that had proved of greatest service in heat stroke *-viz., the wet pack. The opportunity for testing the correctness of my views did not present itself to me, owing to absence from home during several summers and for other reasons, till the sum- mer of 1887, which was an exceedingly hot one, and cases of summer complaint were numerous. As the treatment was very nearly alike in all cases, I shall report here only a few, selected from the whole number treated by me after the new method for some special feature that each pre- sented : Case I.-Sammy F.. aged nine months, tenth child, bottle-fed with Nestle's milk food since his third week, rather stout, always a very good child, giving his mother but little trouble, is now in a period of dentition. The family occupy a small house of eight rooms on one of the best streets in the city. Some years previous they lost two children with summer complaint. In the early part of July the child became very restless, cried all night, was very fretful through the day, and wanted to be carried around constantly upon his mother's arms. Diar- rhoea has set in and continues to grow worse. He is nauseated, * Heat Stroke (Thermic Fever) in Infants. By H. Illoway, M. D. Medical News, August 8, 1891 ; Cincinnati Medical News, September, 1891.. 12 SUMMER COMPLAINT. gags, and when he takes food be vomits. He usually sleeps up stairs, in a rather small bedroom, in a bed with one or two adults. As the nights were exceedingly hot, I advised the mother to keep the child down stairs, even throughout the night, in a rather roomy parlor and much cooler than the upper Hoors. For the sickness at tbe stomach I prescribed a weak solu- tion of cocaine, a dose of which was but eight drops, and given at intervals of from two to three hours. For some reason or other the mother did not take my advice with regard to keep- ing the child down stairs, and the cocaine was of but tempo- rary benefit. For the time being the nausea was allayed, tore- turn in a little while after the administration of the medicine. The diarrhoea continued, the number of stools increasing in fre- quency despite the usual mixtures that were given to check them-in short, the child grew very much worse. Though I had hesitated at first, I determined now to follow out tbe thera- peutic indication above mentioned. I therefore directed the mother to wrap the child in a wet pack (as already described in my paper on Hydrotherapy and my paper on Heat Stroke), to renew it when warm, and to continue this process for two to three hours ; then, when the child was quiet, to leave it off, and resume again as soon as he manifested any signs of irritability. The mother did as I directed, and the effect was marvelous. The infant went to sleep and slept very quietly and nicely, and even the renewal of the pack did not disturb him much. As soon as tbe process was completed he fell asleep again. This continued thus nearly the whole of the first day. The nausea disappeared, the diarrhoea was very much improved, and the child every way better. The mother continued the application of the wet pack every day-that is, two to three in the morning from about 10 a.m., and three to four in the evening-for two months, and the marked improvement obtained at the outset con- tinued. His appetite was fair. The food (Nestle's) was fairly well borne, though not quite as it should be, and not in the usual quantity. A little red wine (claret or Ives's seedling) and water, with a biscuit broken in it, was given twice daily and very much relished. The diarrhma was almost completely arrested, not more than three to four stools a day, and frequently not more than one SUMMER COMPLAINT. 13 or two, and these of good character ; when the stools were more than the latter figure they usually contained some undigested masses. He slept well at night and did not disturb his mother much. When the cooler weather set in, the infant, which had weathered the great heat of the season and had gone through the process of cutting four teeth, was in excellent shape, some- what thinner, it is true, but very fat in comparison to other chil- dren similarly affected that I had seen in my former experience. It took but a very few days until he began to eat again his usual quantities, and very rapidly regained his fat. His mother, who had had the sad experience with this mala- dy above mentioned, said to me, when the child had fully re- covered, that she would not have believed it possible to accom- plish so much with so little medication had she not witnessed it herself. Case II.-Baby R., aged eleven months; well developed, well nourished, and nursing at the breast. The family occupied the lower floor of a house, the front half of which was occupied by them as a store and the rear half divided off into living-rooms. The bedroom was thus in the center, a small compartment without any windows and no ventilation except what came from above, the partitions not reaching to the ceiling. The family is well to do, and every- thing is kept scrupulously clean. Was called to see the baby in the morning and learned that it had been seized with vomiting and diarrhoea, whether in the night or in the early morning hours the mother was not posi- tive. Temperature, 102° ; it is extremely restless, tosses about in its cradle, and cries constantly. I prescribed a febrifuge mixt- ure (spirits of Mindererus, sweet spirit of niter, and a minute quantity of tincture of aconite), but this was vomited every time, and about 1 p. m. I was hurriedly called to see it again. I now directed the mother to wrap the child in the wet pack, and this to be continued till night; then to discontinue it for a while and to resume it again when the child became restless. 1 also directed that it be not given the breast, but that a tea- spoonful of equal parts of lime water and milk, cold, be given every half-hour to allay thirst. This was done; the diarrhoea 14 SUMMER COMPLAINT. and vomiting ceased at once, and after four hours the mother again gave it the breast, which it nursed; the milk was re- tained ; the lime water and milk were then discontinued. The wet pack was continued for two days, with intervals of absten- tion, and the infant then discharged well. Case III.-Baby L., aged fifteen months; weaned; well- developed child ; eats, and is evidently well nourished. The four incisors, both upper and lower, cut for some time already. Is now in the developmental period of another group-the an- terior molars. The family lives on the third floor (top) of a tenement house, occupying two large rooms, separated, however, from each other by a stairway. There are not more than three families in the house proper, the lower floor-separated from the others altogether-being occupied by a store. The apartments of the family are scrupulously clean and fairly well aired, the rooms having three and two windows respectively. Nevertheless, the heat in them, especially in the large front room-the best room- is exceedingly great; at times it seemed to me like a bake-oven and this though no fire, for any purpose, was made in this room. The heat poured down from the ceiling and was so great that when I came to visit my little patient, despite the perspi- ration rolling down, I kept my hat on to shield my head from it. The infant is exceedingly restless, tosses about in its cradle, cries constantly, and is especially bad at night. The mother is almost distracted. It vomits and has some diarrhoea; the evacu- ations are of a greenish color. I directed the mother to wrap the infant in the wet pack and continue its application for three hours; then to intermit and resume again as soon as the child again became restless. For the thirst, to give it lime water and milk, equal parts, a tea- spoonful every half-hour. The effect was excellent. The vomiting ceased at once; that is, the milk and lime water ad- ministered were retained. The diarrhoea was arrested. The child fell into a slumber and slept quietly and peacefully for quite a time. After the condition of the child had been greatly improved under this treatment I advised taking it out and keeping it out of the house even at night. As long as it was SUMMER COMPLAINT. 15 kept out it rested well, but when taken in it was but a little while till the child was again restless, tossed about, cried, until wrapped in the wet pack, when it at once became quiet and went to sleep. However, after a while the mother, perhaps owing to multi- farious duties incumbent upon a poor woman with a large family of small children, somewhat relaxed in her attention to the baby, and one morning early I was hastily summoned to see it, as it was very bad, as the messenger said. I went at once and found the child almost wild, as one might say. At times it almost stood upon its head, the head and feet resting upon the bed and the body forming an arch between these two points. There was marked rise of temperature, but it could not be ascertained by the thermometer, as the child could not be kept quiet or in one position for two minutes at a time. There was great thirst. I at once had the child wrapped in the wet pack and had some sherry wine brought, which I poured into a tumbler upon a lump of ice, and gave the child four to five small teaspoonfuls of it-two drachms and a half perhaps in all. The child quieted down in a very little while, and went into a refreshing sleep. Anxious to learn if possible what had caused this sudden change, I inquired of both father and mother as to their treatment of the child since the day before. The father told me that the child had been very comfortable the day be- fore ; it had been in the wet pack twice. In the evening he had taken it out and kept it out till 1 a. m., and it had slept, well and even soundly, and had taken its milk and lime water. Feeling tired himself, he had then gone into the house and put the child into bed. It had slept till about 3 a. m., and then be- gan to cry and toss around and stand upon its head; it had also vomited some milk that they had given it. When asked why he had not put the child in the pack, he said that he really could not say whether it was forgetfulness, owing to fatigue, or whether they were frightened by the child standing upon its head. As the infant seemed to me to suffer considerable pain-and to this I attributed the remarkable positions it would take-and as it displayed some nervous symptoms (slight twitchings), I pre- scribed a mixture of chloral hydrate in lac asae fcetidae, to be 16 SUMMER COMPLAINT. administered by rectal injection if needed; but so soothing was the effect of the pack that it was not required. The plan of treatment pursued was this: Twice in the day, oc- casionally three times, the child was wrapped in the wet pack and kept therein for an hour and a half to two hours. In the even- ing it was taken out and kept out the greater part of the night, except on the rare occasions when it rained, and then the house was much cooler-sufficiently to permit of the child being kept in. The food which it received was milk-plain, ordinary milk -mixed with a little more than one third lime water. This treatment was carried out faithfully by the parents for two long months, I visiting the patient occasionally to keep myself fully informed as to the progress made, and for the pur- poses of history. When the cooler weather set in the child did not show any evidences of suffering; it had weathered that frightfully torrid summer in excellent condition; it was reduced somewhat, it is true, but not more so than other children that had kept well, and it was but a very short time till it had re- gained its previous weight and vigor. It had also cut, during the period referred to in this history, the four anterior molars and two lower canines. Case IV.-Baby II., aged ten months; partly nursed at breast, but chiefly bottle-fed with milk and lime water. A large child. The family occupied a large, airy house in an ex- cellent part of the city. They had just come from New York city, where the baby had been taken sick with summer com- plaint and a rather bad prognosis made for it. The child was restless day and night; wanted to be carried upon the arm, and cried almost incessantly. Both father and mother seemed dis- tracted. It vomited, no matter what was given it, and had a marked diarrhoea, using a great number of diapers daily. It was very much emaciated. For the purpose of assisting the stomach in digesting any material that might remain in it, and for the purpose of allaying its irritability, as also that of the intestinal tract, I prescribed a powder of- SUMMER COMPLAINT. 17 R Bismuth, subnitrat gr. viij ; Pancreatin (F. & R.) gr. iv; Sodii bicarbonat gr. j. M. Make one powder. One such powder to be given three times a day. For the great thirst, which was evident, a little good sherry to be poured upon ice, and two or three half-teaspoonfuls to be given every two or three hours. To wrap the child in the wet pack and allow it to remain for two hours and a half and then to leave off; to resume again as soon as the child became restless. To abstain from bottle feeding. Two days afterward I was sent for again to call and see the child, as it was worse. I called and made inquiry and found that my orders had not been carried out with regard to the wet pack. The powders had been given, so also the sherry, and it had been fed but little. The vomiting and diarrhoea continued as before, and the restlessness was as marked-greater, if such a thing was possible. On learning this, 1 asked the mother why she had not fully carried out my orders. She made answer that it was too much trouble, and that the child would not live any- how ; her physicians in New York had said so. All she wanted was something to quiet the child so that it would not cry so. I gave her a sound lecture upon the duties of a mother, with rather vigorous denunciation of her conduct, and told her to get whom she pleased, but that 1 would not treat her child any longer. She begged me to continue, and promised faithful com- pliance. The effect of the pack was as excellent in this as in the previous cases. The child became quiet and slept well while in the pack, and even when out of it. Already, after the first few days, it was much quieter than previously. The vomiting and diarrhoea ceased. The treatment as described was continued (under careful supervision), and under it, despite the hot weather, the child began to gain. To still further assist recovery of vital power, embrocations of cod-liver oil, twice daily, into the axilla were added to the treatment, and as the mother did not have sufficient milk, a little strained oatmeal was allowed morn- ing and evening. The child continued to do well and to gain 2 SUMMER COMPLAINT. 18 in flesh, and after a week of cooler weather it was as fat as hutter. Case V.-Baby M., aged ten months, partly nursed, partly fed-mostly fed, however, as the mother says she has but little milk. A large child. The family live in the attic of a five- story tenement-house and are exceedingly poor. The child be- coming sick, it was taken to a college dispensary for treatment. The physician in attendance gave her some medicine, but at the same time informed the mother that the child was in a dangerous state, and that its death might be looked for in two or three days. Upon hearing this, she brought the child to my office for treatment. The baby presented the usual symptoms-rest- lessness, vomiting, and diarrhoea, and, superadded to all this, a state of feebleness that I ascribed to previous insufficient feed- ing. I reassured the mother and allayed her fears. I then di- rected her to wrap the child in the wet pack (she had witnessed the procedure in Case III) and to continue this at intervals for two days, then leave off; but always thereafter to keep the child well cooled off either by the cool sponge bath, cool bath, or, if it became very restless at any time, by means of the wet pack. To keep it out of the house most of the time; to give it every three hours (later on four hours) ten drops of good whisky in a teaspoonful of cold water. Not to feed it at all for the day, and not to nurse it oftener than every three hours and a half. Directed the mother to nourish herself better. Five days afterward the mother again brought the child to my office to show me how nicely it had done. It was apparently in good health, and kept so throughout the whole summer. Case VI.-Baby M., aged twelve months, a well developed child and apparently well nourished ; weaned since tenth month. The two central incisors, both upper and lower, already cut. The family live on the ground floor of a frame barrack, in two miserable back rooms, one of which is used as a kitchen and dining-room, the other as a bedroom for the family-two adults and three children. The rooms are rather dirty. Child is very restless ; cries day and night; vomits everything given it; diarrhoea. Temperature 101'5°; considerable emaciation. Treatment: The wet pack, as already described in the other SUMMER COMPLAINT. 19 cases; to abstain from feeding the child for the next twenty- four hours, and to give it during that time nothing but lime water and milk, equal parts-one drachm every half-hour. Under this treatment improvement was rapid. Vomiting and diarrhoea airested; temperature normal; child quiet. I now- advised the mother to see that the child was kept cool by spong- ing with cold water, the cool bath, or by occasional application of the wet pack ; to feed it for a time on nothing else but boiled milk, with an addition of one third its bulk of lime water. The child kept well, despite the great heat, and after a time a regular dietary was prescribed for it. Summarized, the results obtained with this treatment were: 1. It at once calmed the restlessness and fretfulness of the child and gave it rest and refreshing sleep. The value of sleep-quiet and invigorating sleep-to the sick infant need not be expatiated upon, as it is patent to all who have treated children with any attention. 2. Cessation of the vomiting. 3. Arrest of the diarrhoea, or at least such decidedly beneficial modification of it that it ceased to be a source of danger. 4. Improvement of the digestion. 5. The children were maintained in very good condi- tion, and when the cooler weather, especially the cooler nights, set in they rapidly and in brief time regained their former weight. These results were certainly most remarkable in their excellence and far'superior to any that I had ever obtained with any other plan of treatment or that I had seen ob- tained. However, in a certain number of cases there was still room for further improvement in a certain special direc- tion-viz., the digestion of the infant. Though the vomit- 20 SUMMER COMPLAINT. ing ceased and the diarrhoea was arrested, or at least so greatly modified that it did not constitute any more a source of danger, and though the children picked up, still the fact remained that the digestive power of the infant was enfeebled, and its feeding required the greatest tact and attention. It suffered from some form of dyspepsia; undigested particles were occasionally found in the stools; and any neglect of the mother in the matter of food was followed by an increase in the number of discharges and the development of considerable flatus. The question that naturally presented itself to me was therefore this: In what especial manner is the digestive function of the stomach affected by the a?tiological factor, heat ? An answer to this was readily found in the investiga- tions and experimental studies made upon this point by others. It is now a well-established fact, demonstrated by numerous clinical investigations, that in all febrile states there is a diminution which may amount to a total sup- pression of the hydrochloric acid secreted by the stomach. And it is not requisite that we have a very high degree of temperature; even a moderate elevation will have this effect. This has been well shown by the investigations of Gluzinski.* As is seen from Table I of his paper, his patient (typhoid fever-exanthem, typhoid.), with a tem- perature of not more than 102° F., had no hydrochloric acid in his gastric secretion, as was shown by careful ex- amination of the stomach contents; this absence of free 1IC1 continued even at 99°+ F. It was only when the temperature had descended to the normal that 11C1 was clearly demonstrable in the stomach contents. Even Sasseckif and Edinger, who oppose this statement as too * Gluzinski. Deutsch. Archie f. k/in. Med., 1888, p. 484. | St. Petersburger Mediz. Wochenschrift, 1878, No. 19; Deutsch. Archie f. klin. Med., loc. tit. SUMMER COMPLAINT. 21 broad, acknowledged that in all febrile states where dys- pepsia is present, this dyspepsia is due to the absence of or deficiency in IIC1. It might, perhaps, be claimed by some that this defi- ciency was due rather to the effect of the malady upon the economy in general than to the pyrexia eo ipso. This point has also been very clearly established by the experi- mental studies of Manassein.* This investigator found that in animals put into a febrile state by artificial over- heating, the stomach secretion showed a marked deficiency in IIC1 and a consequent diminution of its digestive capa- city. Furthermore, his experiments have shown that such a deficiency of IIC1 may occur even when the pepsin con- stituent of the gastric juice is normal in amount. " Auf Grund des eben angefiihrten halte ich mich zum Schlusse, dass bei fiebernden Thieren die Sauremenge in dem Magen- safte der Quantitat des Pepsins unentsprechend sei, berecht- igt." The conclusion was therefore necessarily this : that the dyspeptic condition was due to a deficiency of IIC1 in the gastric secretion. The further results of this study were an additional ex- planation of the marked beneficial action of the wet pack and the further therapeutic indication : To assist the digest- ive function where it still remains enfeebled by the adminis- tration of hydrochloric acid. I determined, should the opportunity offer, to carry out in my treatment of summer complaint, in addition to the measure that had given me previously such favorable re- sults, the last-mentioned therapeutic indication. However, the material, so far as 1 am concerned, has been very scant, but a small number of cases that would come under the category of summer complaint, as described at the out- * Manassein. Virchow's Archiv, vol. Iv, p. 423. 22 SUMMER COMPLAINT. set, having come under my observation since. Of these, I shall report in detail but three. Though I was fully convinced of the correctness of my conclusions, and though 1 had administered pepsin and hy- drochloric acid in certain cases of infantile dyspepsia, I had not the courage, when the time arrived, to break at once with the received traditions and to strike out in a course directly the opposite to that recommended by all the authorities in paediatrics; and that is the explanation for the apparently halting manner in the treatment of the first case to be reported. Case I.-R. F., aged four months, a stout and healthy child, that I have known since its birth. It was nursed at the breast for about five weeks, and then the mother's milk gave out and it was given the bottle with Nestle's food. This is the sister of Sammy F. reported as Case I, ante, who is now a big fat boy. The surroundings of the child are the same as reported above. August 1st.-The night previous, of July 31st, was excess- ively hot. The baby was restless and irritable, and had, as the mother, a very intelligent lady, reported, a marked eleva- tion of temperature. The mother, recollecting the previous practice, had wrapped the child in the wet sheet, but only once, as she was in doubt as to its applicability in so young a child. For the time being it did good, however, and the child rested and had some sleep. The next day, August 1st, was equally hot and close. The child was restless, crying continu- ally; it vomited; diarrhoea set in, and till evening the child had eight stools, when I was sent for to see it. It presented the characteristic shriveled appearance, had considerable eleva- tion of temperature, and great thirst. I advised that the child be put in the wet pack and that this be kept up for at least two hours; forthethirst, that it be given a teaspoonlul of lime water and milk, equal parts, cold, every half-hour. August 2d.-This was done. The baby went to sleep in the pack, and slept well even after its discontinuance; it did not vomit any more. The child is brighter this morning; does not SUMMER COMPLAINT. 23 vomit; and has had but two stools since last evening. This treatment was kept up till the next day, and then the child be- ng much better, it was given its bottle, though in smaller quan- tity and at longer intervals. The applications of the pack were repeated at various times for the next few days, and the benefi- cial effect maintained ; still the digestion of the infant left much to be desired. I finally mustered up courage to abandon the beaten track and follow out the therapeutic indication last mentioned-viz., to administer hydrochloric acid. Being somewhat at a loss as to the best manner of adminis- tering this remedy in this case, 1 took advantage of a formula given by Jacobi* and credited to Dr. J. Rudisch, which is as follows: " 7b one pint of water one half teaspoonfid of official di- lute muriatic acid is to be added. To this mixture add one quart of raw, cold milk; mix the two liquids thoroughly, and then boil for ten or fifteen minutes.'1'1 I instructed the mother in the details of preparation of the above nutriment, adding to the formula that only water that had been thoroughly boiled previously and cooled should be used, and gave explicit directions as to the quantity to be given at a time and as to the intervals -namely, three ounces every two hours and a half. For further precaution I had but half the quantity prepared at a time. The child took the milk thus prepared very well and throve nicely upon it. It was about the 2d or 3d of September when an incident happened which was rather unpleasant. The child was seized in the afternoon with a profuse diarrhoea, and till evening, when I saw it, it was more dead than alive. I directed the following treatment: Subnitrate of bismuth, two grains every two hours. A mild sinapism-equal parts of wheat Hour and mustard stirred into a paste with cold water-to be applied over the abdomen and to be shifted till the whole belly was reddened. To give it eight drops of whisky in a teaspoonful of cold water every two hours. In place of its * Am. Jour, of Obst., vol. xii, No. 3. Treatment of Infant Diar- rhoea and Dysentery. By A. Jacobi. Reprint, p. 10. 24 SUMMER COMPLAINT. food, which was inhibited, I gave half a teaspoonful of Reed & Carnrick's liquid peptonoids* every two hours. In three days under this treatment the child recovered, and was again able to take its bottle with Nestle's food, to which the mother recurred again; but, as it did not tolerate it well, it was again given milk (obtained from a cow kept by a private family, and therefore rich) diluted with boiled water, at first one half and then one third. The cooler nights setting in, the baby was soon as fat as ever. I can only explain this incident in one of two ways: either it was due to carelessness in the preparation of the milk-and there is good ground for this belief, for the mother, seeing the child doing well, became somewhat lax in her supervision, and allowed her daughters, very young girls, to prepare the food; and every physician knows how difficult it is to get an accurate history of things if the family are at fault-or it may have been possible that the IIC1 mixture was continued too long and a state of gastric hyperacidity created, and thus the diarrhoea produced by the exaggerated peristalsis to which this state gives rise. This can be readily understood when the fact is kept in mind that in the infant the stomach and intestinal tube are very nearly one organ. Case II.-Baby R., aged seven months, bottle-fed with condensed milk since the second month; family live in a tene- ment-house, occupying three rooms on the third door. The apartments are clean and have fair ventilation. August 3d.-Called to see the child. The history of the child's illness the same as in the foregoing case-restlessness; crying, especially marked at night; vomiting; diarrhoea; some elevation of the temperature. Treatment.-The wet pack as already described. To allay thirst, a teaspoonful of milk and lime water, equal parts, cold, every half-hour. In the place of food, to give it-that is, be- * This preparation is an excellent one and has done me good service in many cases of infantile dyspepsia and gastric catarrh due to over- feeding, in which I desired to withdraw for a short time the usually given food. SUMMER COMPLAINT. 25 ginning not earlier than the afternoon-half a teaspoonful of Reed & Carnrick's liquid peptonoids every two hours. Jfth.-The child is in good condition ; has slept well the night previous; no more vomiting, and diarrhoea arrested ; but three stools since my last visit. I instructed the mother to re- peat the wet pack whenever the necessity therefor arose, and to look carefully to the child's feeding. 10th.-I was sent for again. The child, though doing fairly well, had occasional recurrence of the diarrhoea, and the mother desired something for that. Believing that this recurrence of the diarrhoea was due to indigestion, I instructed the mother in the preparation of Rudisch's milk, and directed her to give no more than five ounces and a half at a time, and not oftenerthan every three hours. To let me know then how the child got along. About six weeks after this last mentioned visit, having occa- sion to be in the house, I inquired of the mother how the milk had acted. She informed me that it had done very well; that she had continued it for two weeks, and, the child doing well and gaining, she returned to her ordinary food, as the preparation of the milk required too much of her time-more than she could spare, as she was engaged in work that she could not neglect any longer. Case HI -Baby B.. aged seven months, apparently a well- nourished infant, nursed at the breast and also fed somewhat. Of good size for its age; cutting its upper incisors. The family live in two back rooms, opening upon a porch, of a tenement-house in a narrow street-one that is generally not over clean. The child is very irritable and fretful through the day, and cries the greater part of the night. It has a pro- fuse watery diarrhoea ; considerable thirst, as it takes water with great avidity; slight elevation of temperature above nor- mal, 99'6° F. Ordered chalk mixture with syrup of ginger. Two days thereafter the child was again brought to the office; as its father said, it was no better; he also brought a soiled diaper along to show me the character of the stool. It was white and consisted principally of unchanged flocculi of casein. I ordered the baby a cool sponge bath-ordinary hydrant water, to which 26 SUMMER COMPLAINT. a little warm water had been added-twice daily. Sponging of the abdomen especially with cold water. Inhibition of artificial food and proper regulation of breast feeding. Medicine.-Acid, hydrochloric, dilut., gtt. j, in a teaspoonful of slightly sweetened water every two hours. I also advised a measure which I had found useful in other cases and to which I shall recur again-viz., the mother to sponge herself with cold water, at least the upper part of the body to below the breasts, twice daily-in the morning before nursing the child, and at night before retiring. 1 saw the child no more: but a short time thereafter I met the father and he told me that they had given the medicine for three days, and the child ap- pearing well, they had discontinued it. The child has remained well since. As already stated, the cases of summer complaint that came under my observation from the summer of 1888 to the present time were but few in number-ten; of these, there were six in which a persistence of a certain degree of indigestion led to the administration of hydrochloric acid in one or the other described form. The result of such ad- ministration in these few cases was very satisfactory; the digestion improved rapidly, and in consequence thereof the appetite became better, and the stools normal in character. Furthermore, in children fed with the bottle, the milk prepared according to Rudisch's formula solved in a satisfactory manner the question of what to feed for the time. The accident that occurred in Case I of the second series can not be regarded as testimony strongly contra- dicting the assertions here made; for, as already stated in the history, there were several factors that may have tended to produce it; but the most important of all, perhaps, was my lack of precise notions as to the length of time for which the acidulated milk should be administered. SUMMER COMPLAINT. 27 Total number of cases. Recoveries. Deaths. First series, 1887 Second series 25 10 25 9 1 Total 35 34 1 Summary of Results. Though the number of cases is comparatively small, it can nevertheless be safely maintained that the results ob- tained by me, as illustrated by the table, are far superior to what have ever been obtained with any of the other meth- ods of treating summer complaint. And even the case which died strongly illustrates the value of the therapeutic measures here indicated, as can be seen from the following history: Baby F., aged five months, bottle-fed with condensed milk; had received the breast for about four weeks; puny. Sister of baby F., referred to above. When the mother discov- ered about the second month that she was again pregnant, she was disconsolate. She bad already had fourteen children and several miscarriages, and the hard work and suffering that she had gone through with them had told on her frame, producing a scoliosis. She therefore resorted to various drugs-ergot, quinine, cotton root, pennyroyal, and to patent nostrums-to rid herself of the impediment, without avail, however. When about five months gone she had a recurrence of an old middle-ear catarrh ; she became greatly debilitated and had attacks of syncope ; she had to be kept in bed for a week at a time, and stimulants free- ly administered became requisite. To cap the climax, financial difficulties overtook the family shortly after her confinement, and though no direct suffering ensued, it entailed great mental distress upon her and put upon her a great amount of work that was generally attended to by the husband. Family living in a small, narrow house adjoining a livery stable, in a very excel- lent street, however. May 29, 1890.-The weather is very hot. Called to see the 28 SUMMER COMPLAINT baby. The mother said that the baby had had a greater num- ber of stools than usual since the 10th. but that she bad not given the matter much attention. To-day the infant had ten stools. I asked to see the diapers, but there was none to show just then. The mother described the stools as green- ish. I ordered a mixture of bismuth subcarbon, with some aromatics. June 5th.-The bismuth did not do any good. A couple of diapers were shown me; the stools were of a greenish color. There is some elevation of temperature; the child is peevish, restless, and rather haggard in appearance. Vomits occasion- ally. I called the mother's attention to the necessity of apply- ing the wet pack, as she had done in the other two children, and of frequent sponging after the temperature had been re- duced. 1 also directed that the child be fed with milk prepared with hydrochloric acid, with which she was already familiar. 6th.-Child is better. 7th.-Continues to improve; stools not more than eight in the twenty-four hours and rather small; still greenish in color, with the addition of some mucus. To-day the stool was but a few hard lumps of casein. As, in my opinion, this clearly pointed to either an inefficient preparation of the milk or to the administration of plain milk, I called the mother's attention thereto, and urged upon her a little more care upon this point. The child had slept much better the night previous, and pre- sented a much better appearance. 15th.-Stools still of the same frequency-eight in twenty- four hours. Directed bismuth subnitrate, gr. ij, every three hours. 20th.-Stools still as frequent. Child is bright, has a fair ap- pearance ; in no way the aspect peculiar to children with sum- mer complaint. It appeared to me, however, that the rules laid down for the care of the child were not very strictly observed, neither in the matter of the wet pack and spongings nor in the preparation of the food; but more especially in the latter. I therefore advised the substitution of Reed & Carnrick's pepto- genic milk powder, and impressed upon them the necessity of sponging the child ; furthermore, I directed that whenever the SUMMER COMPLAINT. 29 head got warm to put upon it a towel wrung out of cold water, and I instructed the sister, a girl of fourteen, and the little nurse girl, upon whom the care of the child principally devolved, in this last point. 23d.-The milk powder preparation disagreed with the child, and the milk with hydrochloric acid was resumed. The child strained somewhat at stool, and for this I directed a small rectal injection of a strong decoction of peppermint with the ad- dition of a few drops of paregoric-gtt. vj. This relieved the trouble at once. July 31st.-Since last report the child did well. Once about the middle of the month during the hottest part the child had a slight recurrence of the trouble, but the same measures, pre- viously employed, soon relieved it. This evening was called to see the child. The weather is extremely hot and has been so for the last three days. The mother states that the child had some diarrhoea, but the injection of peppermint decoction, as above described, soon relieved this. However, the child is rest- less, whines, and seems rather feeble. Some tendency to vomit. Body cool, but the head, especially about vertex and occiput, is hot. I directed the child to be immediately taken out of the house, which was frightfully hot. The cold applications to be applied to the head. As a stimulant and to relieve the evident nausea, I prescribed a few drops of spirit, amnion, aromat. to be given every three to four hours. The child was taken out in its wagon, a cold compress applied to the head, and in a very few minutes thereafter it was enjoying a sound sleep. August 2d.-The hot weather continues; atmosphere sultry. Called to see the baby. Bowels loose; stools have a moldy odor. The mother gave it last evening an injection of peppermint and put it in the wet pack. As long as it is kept in the wet pack the bowels are checked, the child ceases to moan, and seems to feel much better. It did not take the bottle so well through the day, but takes it much better this evening. Four stools to-day; while I was in the house the child had a stool; it was of the consistence of pap and light yellow in color. It takes ten drops of whisky with a little cold water every three to four hours. 10th.-Child doing well; looks bright; has a fair appear- 30 SUMMER COMPLAINT. ance ; thin, but not a wrinkle in its face. Sleeps fairly well, though occasionally it may wake up two to three times in the night, cry a little, and go to sleep again. 16th. -The child is very bad; it has lost its good color; face is wrinkled; body much emaciated; is very feeble; extremities cool; lies in a sort of stupor. I ascribed this sudden change for the worse to a sudden and remarkable fall in temperature that occurred at this time-a fall so great that the houses actually felt cold and chilly. Coming on so suddenly, it had a very depressing effect upon my little pa- tient. ^Oth.-Child died this morning. That, despite the great difficulties the child labored under-a constitution undoubtedly already prenatally enfeebled, deprived of mother's milk, a mother rendered almost indifferent by amul- titude of troubles and worries and sickness (she suffered from menorrhagia and pains in the back during the. whole period em- braced in the history of the child's illness), almost wholly de- pendent for the necessary attentions upon the two little girls, children themselves-it should have withstood so long and so well the ravages of the torrid summer of 1890, and that with but trivial medication, as can be seen from the history, I regard as a triumphant demonstration of the great value of the thera- peutic measures here advocated, and ergo of the position here assumed as to the true nature of summer complaint. I said, with- stood so long and so well. The history certainly proves this; and I am furthermore of the positive conviction that had it not been for the very great depressing effect upon a system already im- paired in vitality by the long struggle, of the sudden cold spell, the child would have survived. It can not be denied that the proposition here laid down as to the aetiology of summer complaint is opposed by emi- nent paediatric authority in this country. But upon what grounds ? J. Lewis Smith, in his treatise The Diseases of Infancy and Childhood, edit. 1890, in the chapter Intestinal Catarrh SUMMER COMPLAINT. 31 of Infancy (Entero-colitis), page 788, says : " The fact is therefore undisputed and is universally admitted that the summer season, stated in a general way, is the cause of this annual recurring diarrhoea. That atmospheric heat does not in itself cause the diarrhoea is evident from the fact that in the rural districts there is the same intensity of heat as in the cities, and yet the summer complaint does not occur." Louis Starr, in his very excellent book The Diseases of the Digestive Organs of Children, makes a similar statement, edit. 1886, chapter Entero-colitis, page 178. He says : " There must be another factor at work here besides the ele- vated temperature, since in the open country immediately surrounding affected cities, where the thermometer ranges nearly as high, the disease is of exceptional occurrence." Shattuck, the translator of Strumpell, in the chapter on cholera infantum, in a paragraph in brackets, repeats this argument. To anyone who has lived both in the city and the coun- try the fallaciousness of the argument will be at once ap- parent. What are the facts I 1. It is true that the intensity of heat is the same in the country as in the city, but only in the open plain and only part of the day. 2. The dwellings in the country are much cooler, even throughout the day, than those of the city, and certainly much more so than those occupied by the urban, middle, and poorer classes. 3. There is a vast diifcrence between the night atmos- phere of the country and that of the city. The night at- mosphere of the country is cool even to chilliness; that of the city is hot. Though for part of the day there may be the same in- tensity of heat in the country as in the city, nevertheless the houses, not alone in the farming districts but also in 32 SUMMER COMPLAINT. the small villages, are cool. They are generally built apart, and whatever of breeze is blowing finds but little obstruc- tion to penetrating them, while the shaded windows keep out the hot rays of the sun. Then the shade trees which usually surround these habitations still further tend to keep them cool and comfortable. What the houses in the large cities are-especially in the crowded districts with their narrow streets, the cramped and crowded habitations swarming with living beings, and their cooking and washing, and the multitude of lights at night -is so well known that it need not be expatiated upon here. But the greatest difference is in the atmosphere of the night. In the country the air is cool and pleasant, and re- freshing sleep waits upon tired Nature. But how is it in the great city ? While the heat was great throughout the day, it is stifling at night. With the setting of the sun and the fall of darkness the immense mass of brick and stone of house and pavements gives forth the heat absorbed through- out the day, and an atmosphere is created very much like that of a furnace. Here poor tired humanity seeks in vain for a cool spot to woo sleep, and house-tops and porticoes and cellar doors and hallways are turned into sleeping apart- ments. But the poor little infant is kept in the room which is too hot for every one else, in its cradle with feather pil- lows, perhaps a feather bed to lie on. Furthermore, a light is usually kept burning all night and adds its share to ren- der the atmosphere still more intolerable. And it is really not so much the heat of the day as it is the great heat of the night of the large cities, which de- prives the little children of their much-needed rest, that is the factor in the production of summer complaint. The proof of this lies in the fact that the children are attacked after the first hot nights ; that the children are much more SUMMER COMPLAINT. 33 restless and seem to suffer more at night than in the day- time ; in the repeatedly verified observation that though the days be hot, as long as the nights remain cool summer com- plaint does not occur ; in the generally admitted fact that with the beginning of September summer complaint ceases -and certainly we still have hot days in September ; but the nights are cool. It is this continuous heat, day and night, of the city that causes summer complaint. It is the coolness of the coun- try at night, the coolness of the early morning hours, the coolness of the dwellings, that gives it exemption from this really dread disease. It is for these same reasons that the children taken to the country do so well. These are facts patent to all and can not be gainsaid. Foul odors, decaying vegetation, domestic filth, and the like have been set down by these authors as the direct causes of summer complaint. Any such aetiology, however, can be at once excluded for the following reasons : (a) Summer complaint occurs in dwellings whose sur- roundings are clean, that are themselves kept perfectly clean, wherein the children are kept clean, wherein clothing and bedding are kept perfectly clean. (6) It occurs among the rich in their fine mansions in the broad streets as well as among the poor. (c) Localities with noisome odors are, comparatively, not in any way more afflicted than localities free from them. It is true, as has been said and as I have stated, that the disease is more prevalent in the densely populated dis- tricts of the large cities, which are usually characterized by high tenement-houses and narrow streets; but it is not because of any such fancied aetiological factors as were just mentioned above, for in many instances-aye, in the ma- jority of instances-they are absolutely wanting. But it is 3 SUMMER COMPLAINT. 34 because in these parts the heat is positively greater, both day and night, than in the less crowded districts, or, better, in the newer districts, with their wide streets. Each house in the populous district is much hotter for the further rea- son that so many families dwell therein, usually large ones, and each one cooks, bakes, and washes; at night each one has one or more lights burning. Furthermore, in these, usually the oldest parts of the cities, the streets are short and crooked, and the free access of air to them is cut off by other piles of masonry that block the street at either end. A careful scrutiny of the histories here given clearly shows that in but two out of the ten cases reported was there any ground for the assumption of such an aetiology, and even here it was but slight. That the disease does not occur among the poor only these gentlemen themselves indirectly admit. In the chap- ters on the therapeutics of the disease they recommend re- moval to the mountains or to the sea-side as the best of remedies. Now, such advice can certainly only be given to the richer class who possess sufficient means, and they must be quite considerable for compliance therewith. And cer- tainly such people do not, as a rule, live among stenches, decaying vegetation, and tilth. But we have more direct proof. It is a well-known fact that if these factors are anywhere present it is in the quarter inhabited by the negro population of a city. The squalid, rickety dwellings, densely populated-almost a family to a room-reek with a thousand odors from decay- ing animal and vegetable matter. The streets in which these dwellings are situated-usually alleys or abandoned streets-teem with tilth, being the receptacle for the gar- bage, etc., from the houses on it. The street-cleaning de- partment visits these places only in times when a pestilence SUMMER COMPLAINT. 35 threatens; otherwise they remain undisturbed, year in and year out. Now, if these factors are so potent, the mor- tality among the colored children should be something frightful. How is it in reality ? The following table will show: Deaths from Cholera Infantum.* White. Colored. 1889, June 18 " ' July 42 1 " August 27 1890, June 56 1 " ' July 45 2 " August 22 This table loudly proclaims the contrary of what, upon this theory, we should have expected. Not alone that, but it also clearly indicates that summer complaint is of exceed- ingly rare occurrence among colored children. If foul odors, decaying vegetation, and tilth are the chief factors in the production of summer complaint, then this table is certainly a riddle the solution of which is as yet to be found. It can not be claimed that the colored race has an immunity against such agents, for there are no grounds upon which to base such an assumption; more- over, the much greater mortality of the race, as shown by Southern statistics, clearly indicates the contrary. If heat, however, is the chief aetiological factor in its production, as is maintained here, the exemption of colored children from this disease is perfectly clear. I say exemp- tion, because I firmly believe that, if the cases were thor- oughly sifted and summer complaint separated from the cases in which the vomiting and diarrhoea were due to * This table was prepared for me by the registrar of vital statistics from the records of our city, by the kindness of the present able health officer, Dr. Pendergrast. 36 SUMMER COMPLAINT. the ingestion of decaying animal substances, stale meat, stale fish, etc., and these cases are not so rare, the mortality under the head of cholera infantum would, so far as col- ored children are concerned, have been nil. It is readily explained upon the ground of the much greater tolerance of the colored race for heat-a fact well established and not needing further elucidation here. As additional proof the following brief mortality table is adduced. It is taken from the official records of the health office, giving the mortality by wards for the year 1890 : Wards. June. July. August. Total. 14 2 1 3 16 3 3 1 7 Deaths from Cholera Infantum* In Ward 14 are located slaughter-houses, soap factories, tanneries, melting houses, factories for sausage casings, and other like odoriferous institutions. A thousand smells, dense and strong, assail the passer through this portion of the city. Ward 16 is one of the best wards of the city, free from any odors and smells, nothing more formidable than retailers of meat, and these not many, being located therein. And, still, see what the table says. The ward with the numerous smells had the smallest mortality, and conse- quently must have had a much smaller number of cases than the other. The facts here adduced clearly show, I believe, that foul odors, decaying vegetation, etc.-the factors to which the authors mentioned above attach so much importance-really play no role at all in the production of summer complaint. * This table was prepared for me by the registrar of vital statistics from the records of our city, by the kindness of the present able health officer, Dr. Pendergrast. SUMMMER COMPLAINT. 37 We have also the weight of opinion with us. The well- known Dr. Parrish, of Philadelphia, speaking of summer complaint, says of it: " It begins with the hot weather, increases and becomes more fatal with the rise of the ther- mometer, and declines with the cool weather in autumn. During its continuance it may be observed to vary with every prominent change of temperature* A few very hot days in succession in the month of June are sufficient to call it into action, and during the length of its prevalence a spell of cold weather will diminish if not suppress it." " Let any one take a walk in a summer morning through the thickly-built lanes and alleys of Philadelphia; he will be struck with the appearance of the children, reclining their heads, as if exhausted, upon the breasts of their mothers, with a pale, languid countenance and clammy skin, a shrunken neck, and other signs of debility arising from their confinement during the night * to close and hot apart- ments." f Dr. Joel Shew, the author of an excellent treatise on The Hydropathic Management of Children in Health and Disease, referring to the disease under consideration, says thus : "Effects of Heat.-High atmospheric temperature is manifestly a great cause of this disease. It is aptly termed summer complaint. It commences with the hot weather, etc." J Dr. T. Clark Miller, in an article entitled Cholera Infan- tum and the Weather, says : "Observation also justifies the belief that a continuance of high temperature, for a more or less definite period of six to ten days, is necessary to the * Italics mine. f Children, their Hydropathic Management in Health and Disease. By Joel Shew, M. D., Philadelphia, 1852. t Ibid. 38 SUMMER COMPLAINT. development of the disease, in an epidemic form, in the early part of the hot season, while, as the season advances, the number of days of continued high temperature neces- sary to inaugurate new epidemic outbreaks becomes less. This being true, it is not at all strange that unprofessional grandmothers, as well as physicians, have associated the disease with the continued high temperature as effect and cause, not ignoring the existence of co-operating causes, nor the varying degrees of susceptibility in children." * Finkelnburg f has expressed himself in this sense, and has set forth more especially that it is not so much the high temperature per se as it is its continuance, and particularly its continuance in the dwellings even at night, that is the aetiological factor in the production of the disease and its great mortality. Dr. A. Seibert, in a graphic study entitled Cholera In- fantum and the Weather, has demonstrated for some of the largest cities of the United States what had been already graphically shown by Baginski for Berlin-that the disease prevails in the hot months, that the greatest prevalence is in July, that it diminishes in August and ceases in Sep- tember. It is true that, though compelled by his charts to admit the direct and decided influence of the weather upon this disease, he does not regard a high temperature as the neces- sary factor. He says: " Now, then, we have found so far that, though the temperature evidently has some decided relation to the frequency of cholera infantum, yet we have no right to accept our first impression that the higher the more, the lower the temperature the less, frequent do we find this complaint; on the contrary, we must admit that comparison of monthly means of temperature during the * Med. Record, July 21, 1888. f Berlin, klin. Wochenschrift, No. 49, 1889. Quoted by Bagin ski. SUMMER COMPLAINT. 39 summer months shows that the frequency of summer com- plaint (like its mortality) is independent of the rise and fall of atmospheric temperature." * This conclusion, which is contrary to the direct obser- vation of every practitioner, is based upon an erroneous method of study, as has already been pointed out by Dr. Clark Miller, who very truly says : " A monthly record does not satisfy the requirements, from the fact that there may be two or even three weeks of low temperature, giving the month a low mean, and yet enough of days of high tem- perature to give the month a high mortality record from cholera infantum; or, from a succession of hot days at the end of the month, the cumulative effects show on the mor- tality records of the following month of perhaps low mean." f But we have most striking proof to demonstrate that a study of the " monthly means of temperature during the summer months " is erroneous and leads to false conclu- sions. In his summary Dr. Seibert says: 2. Warm weather (either dry or moist) showing mini- mum daily temperature of not less than J 60° F. brings on the epidemic appearance of cholera infantum invariably in every year irrespective, etc. 3. Summer complaint loses its epidemic character as soon as the daily minimal temperature remains below J 60° F., as in the latter half of October of nearly every year. Dr. Turner,* in bis report upon the Sanitary Condition of Portsmouth, studied the statistics of epidemic infantile diarrhoea (summer complaint) in sixteen towns in England for the ten years from 1867 to 1876. Admitting the influ- * Med. Record, March 24, 1888. f Ibid., July 21, 1888. | Italics mine. # Lancet, July 13, 1878. 40 SUMMER COMPLAINT. ence of meteorological conditions, he finds, by a study of the monthly means of temperature during the summer months for the period given, that a continued minimal tem- perature of 50° F. is necessary to produce epidemic infantile diarrhoea. If further proof were necessary, it could be brought in the fact that summer complaint was never observed at a steady temperature of 60° F., and certainly not at 50° F. Schoppe,* in a study of cholera infantum, expresses him- self plainly and unmistakably to the effect that high tem- perature is essentially the setiological factor of this disease. Dr. A. Baginski, that eminent and painstaking investi- gator of the diseases of the digestive organs of jchildren, is very explicit upon this point. In an address delivered be- fore the Berliner medicin. Gesellschaft, after referring to the graphic study of this disease made by him for Berlin, and published in his Verdauungskrankh. der Kinder, 1884 he says: "Vergleicht mann nun die Thatsachen, die wir fiir Berlin gefunden haben, mit den Thatsachen aus anderen Stadten, so hat mann die eigenthiimliche Wahrnehmung, dass in den verschiedensten Grossstadten sowohl Europa's als auch Amerika's die Erscheinung ganz dieselbe ist, und es ist vom hbchsten Interesse die Curven welche aus Ameri- ka verblfentlich werden f mit unserer Curve zu vergleichen. Es ist fast als ob die Amerikaner die Berliner Curve ab- gezeichnet batten, so genau decken sich die Curven, etc. Under solchen Verhaltnissen ist es begreifich wenn mann die Hohe der Temperatur fur die Mortalitat an Kinderdiarrhoen verantwortlich macht." J Further on he says : " Wenn mann * Schoppe. Der Brechdurchfall der Sauglinge a. seine Behandlung, Bonn, 1887. f I believe reference is here made to the charts of Dr. Seibert, men tioned above. | Italics mine. SUMMER COMPLAINT. 41 sich mit dieser Frage so weit abgefunden hat dass mann, ganz allgemein ausgedriickt, die Hbhe und lange Dauer der hohen Sommertemperatur als massgebend betrachtet, so," etc.* The general effect of this continuous high temperature, with its attendant heating up of the dwellings, is the pro- duction of a state of fever in the infant. This needs no demonstration here. It is sufficiently proved by experimental investigation and clinical study.f The aetiological factor having been clearly determined and its general effect upon the organism of the child being- evident and well understood, the next question, the logical one, that presented itself was this: What special effect is produced upon the digestive tract ?-the system pointed to by the symptomatology as specially involved in this disease. And first as to the stomach. The question of organic lesion required no considera- tion. It was excluded by the aetiology, by the rapidity of the involvement, and most positively by the many necrop- sies which have been made and which have shown the stomach free from such lesion. There remained therefore but functional disturbance-a dyspepsia-to account for the symptomatology. That it is but a functional disturbance has apparently never been doubted. Upon this point there is a consensus of medical opinion, demonstrated by the general use of pepsin, lactopeptine, malt, pancreatized preparations, etc., and by the many different nutritive preparations introduced by manufacturers, and all recommended as a panacea for the dyspepsia of summer complaint. It has been clearly and * Berliner klinische Wochenschrift, No. 46, 1889. f Litten. Ueber die einwirkung Erhohter Temperaturen etc., Vir- chow's Archiv, Band 70.-Heat Stroke in Infants, by H. Blow ay, Med- News (Phila.), August 3, 1891; Cin. Med. News, September, 1891. 42 SUMMER COMPLAINT. definitely expressed by Dr. L. Emmet Holt. In an article entitled The Antiseptic Treatment of Summer Diarrhoea he says : " One conclusion has long been forcing itself upon my mind with increasing strength every summer-viz., that, excepting the rare cases of pure cholera infantum, nearly all the diarrhoeas and intestinal catarrhs of young children are essentially dyspeptic in their origin." * What is the precise nature of this functional disturb- ance ? This was the point to be determined, and in only one way, by taking into consideration the well-established factors in this disease-the setiological factor, heat, and the morbid condition produced by it, the pyrexia-and ascer- taining what special effect they have upon the stomach. What this effect is has been sufficiently demonstrated in the foregoing-namely, an inhibition or marked restriction of the secretion of hydrochloric acid in the gastric juice. In addition to the theoretical considerations which led to this conclusion, and which are amply sufficient in them- selves, being based upon incontrovertible and well-estab- lished facts, we have direct testimony from the malady itself. (a) Leo,f in his studies upon the infantile stomach in health and disease, investigated the condition of its con- tents in one hundred and four children, laboring under various maladies. Of these, twenty-two were cases of cholera infantum-summer complaint. In all these cases there were found, in large quantities, the volatile fatty acids, butyric, acetic, and lactic acids. Now, the presence of these acids in any quantity in the stomach contents is due, as has been amply shown by care- ful investigation, to the absence of IIC1 in the gastric se- * N. K Med. Jour., July 29, 1887; f Ueber die Functionen des normalen u. kranken Magens, etc., ini Sauglingsalter. Berliner klinische Wochen., 1888, No. 49. SUMMER COMPLAINT. 43 cretion.* This is to-day an established fact. The explana- tion thereof is this : All fermentative processes occurring in the digestive tract (and these acids are the results of such) are due to the activity of micro-organisms which abound therein. It is a characteristic of these micro-organisms that a strongly acid medium inhibits their activity. The presence, therefore, of hydrochloric acid, which is a very energetic and strong acid, prevents any and all fermen- tation. f (6) The microscopical examinations of the faeces of summer complaint have shown therein a great number of bacteria, a greater number than are found in the infantile intestinal canal in a state of health. Baginsky, J in his latest discourse on this subject, enumerates eleven different species that he has found therein. It is an established fact that the greater number of bac- teria that are taken up with the food, the drink, the air, are destroyed in the stomach,* and though a few may pass it unharmed-e. g., as is claimed by Lesage || for his green- coloring bacillus-nevertheless, their activity is inhibited, as the effect of the admixture of the hydrochloric acid to the chymus continues even in the small intestine. A It is furthermore an established fact that it is the hydrochloric acid in the gastric secretion Q that is the * Boas. Allgemeine Diagnost. a. Therap. der Magenkrankh.-Ewald Klinik der Verdauungskrankh., vol. ii, p. 26. f Boas. Loe. cit.-Maefadyen, Nencki u. Sieber. Archiv f. ex- periment. Path. u. Pharmacolog., B. 28, II. 1, 2. | Ueber Cholera Infant. Berl. klin. Woehen., 1889, No. 46. * Some New Bacterial Poisons, etc. Victor A. Vaughan. Med. News (Phila.), August 16, 1890. || Archives de phgsiologie normale et path., 1888, No. 2. Le- sage, etc. A Maefadyen, Nencki u. Sieber. Archiv f. experiment. Path. u. Pharmac., loc. cit. Q Ibid., and Boas, loc. cit. 44 SUMMER COMPLAINT. guardian at the portal of the stomach and destroys or ren- ders harmless the invaders that come from without. The presence, therefore, of such great numbers of bac- teria of varied form demonstrates an inhibition or marked diminution of the (IIC1) acid constituent of the gastric juice. We have corroborative evidence from analogous patho- logical conditions. (c) Boas,* in his clinical investigations, has found that in the majority of cases of chronic intestinal catarrh there is anacidity (absence of HC1) of the stomach. Troitzky,) in a recent article on the gastric disturbances in children, says that the majority of gastric dyspepsias in children are caused by the deficiency of HC1 in the gastric juice. The large quantities of gas J ami the acids, especially the volatile, fatty acids, developed in the stomach as a re- sult of the fermentation therein set up, are the direct cause of the nausea and of the vomiting. The Bowels.-The bowels are not affected at the out- set ; after a period, however, a catarrhal condition super- venes, excited by the constant passage of irritating material over the intestinal mucous membrane. The diarrhoea is the direct result of the dyspepsia. The food not being properly digested in the stomach and undergoing abnormal changes therein is thus thrown in an improper state into the intesti- nal canal; it acts as an irritant therein, and provokes fre- quent and abnormal peristalsis and its own more or less early expulsion. These fermentative changes begun in the stomach are * Boas. Loe. cit. f Troitzky. Jahrb. f. Kinderheilk., xxxii, 4; Archives of Paedi- atrics, November, 1891. | Leo. Loe. cit. SUMMER COMPLAINT. 45 continued in the intestinal canal, and still others originated there de novo ; there is consequently a still further devel- opment of flatus (additional to that which has passed from the stomach), readily recognizable by the tympanitic condi- tion of the belly; and this, by the distention it produces and the irregular peristalsis it excites per se, is the chief source of the pain. Diarrhoea and flatulence as a result of indigestion-dyspepsia-are so firmly established in pa- thology that they need no further demonstration here. The variegated color of the stools in this disease, as set forth in the symptomatology, is readily explained. The preen stools, which predominate, derive their color from the presence of a special bacillus, first described by Lesage. * This bacillus is found in greatest abundance in the upper two thirds of the intestinal canal, is very rare in the lower third, and altogether absent in the colon. These green stools constitute that part of the intestinal chymus which is expelled from the small intestine and passes to the ex- terior without previous sojourn in the colon. The yellow stool consists of material which has undergone a more nor- mal digestion, and has taken the course usual in the healthy state. Or it may be that the natural color is due to the fact that the previous evacuations had so thoroughly re- moved the chromogenic bacilli that none were present when this special portion passed their habitat.f If it turn green on exposure to the air, it is owing to the presence of this bacillus of Lesage, but so thoroughly concealed in the cen- tral portion of the mass as to have been occluded from the air. On reaching the exterior, and exposure to the greater atmosphere, the bacillus, which is decidedly aerobic, is at once roused into activity, and produces its special effect- the green color. The white stool (only found in milk-fed * Lesage. Loe. dt., also Bulletin medical, 1887. f On this point see Baginski, loc. cit. 46 SUMMER COMPLAINT. infants) is due to this, that the food is expelled too quickly for any change, except curdling, to take place therein * ; perhaps also due, in part, to a previous clearance of the in- testinal tract of everything except mucus, a considerable quantity of which is found in all stools. The abundance of the mucus is due to the catarrh of the intestinal mucous membrane. The acid stool is accounted for, as will have been al- ready surmised from the foregoing, by the fermentation developed in the carbohydrate elements of the food and by non-sojourn, or lack of sufficient sojourn, in the large bowel. The putrid stools are due to putrefactive fermentation of the albuminoid constituents of the chymus. I believe that there are two important factors concerned in the de- velopment of this form of fermentation - namely, high fever and lesions of the mucous membrane of the large in- testine. In support of this belief may be adduced the fact, -a fact so far at least as my observation goes-that putrid stools are not observed until a late period in the disease,) at a time when we have both high fever and destructive lesion of the mucous membrane of the large bowel. The inhibition of the acid fermentation is undoubtedly a necessary preliminary to the development of the putre- factive process. This is accomplished by the high fever which, at the period referred to, reaches 103° F. and more. The lesions in the mucous membrane of the colon, by ar- resting the normal secretion of this portion of the digestive tract, favor the activity of Bienstock's bacillus, and of other bacilli that may be concerned in putrefactive fermentation. * Beale. Slight Ailments, their Nature, etc., 1882, p. 49. f I hold that the cases called foudroyante are not summer com- plaint. They are cases either of heat stroke (see my paper already re- ferred to, Heat Stroke in Infants) or of true cholera infantum. SUMMER COMPLAINT. 47 My reason for believing that the lesions in the large bowel are more responsible for the putrid stool than those of other parts of the intestinal tract is this: Under normal conditions the albuminoid constituents of the chymus are not affected in the small intestine; it is only after they have entered the large bowel that their decomposition be- gins, and it is only therein that the results of such decom- position as indol, skatol, etc., are found.* It is evident therefrom that this part of the digestive tract is the place specially adapted for the breaking up of the albuminoids into their ultimate elements. It is possible that 1 am mistaken upon this point; how- ever, there is this additional in favor of it: Bienstock main- tains that it is his special bacillus only and solely that effects the decomposition of the albuminoids,! and, accord- ing to the observations of Macfadyen, Nencki, and Sieber, this bacillus is not found anywhere in the organism but in the large bowel. Putrid stools are of rare occurrence, at least in my experience, and when they do so occur, it is only at a late period, as has been stated in the foregoing. Exceptionally we meet with them at an early period in the malady, and then it is only in children who have been fed strongly nitrogenous food, such as eggs, meat, etc. J Epitomizing the foregoing, we have the following as the natural history of the malady under consideration : Summer complaint is a disease produced by the high temperature usually prevalent in the summer months, espe- cially July and August-a high temperature that is con- tinuous day and night. This high temperature produces in the infant a state of pyrexia. * Macfadyen, Nencki, and Sieber, loc. cit. | Ztxchrft. f. kiln. Medizin, 8, 1884. | For explanation of this difference, see Bienstock's article, loc. cit. 48 SUMMER COMPLAINT. As an effect of this pyrexia we have an inhibition of the secretion of hydrochloric acid, or at least a marked diminution in the quantity secreted, and therefore an in- ability on the part of the stomach to properly perform its functions, consequently a dyspepsia. As a result of the dyspepsia we have the diarrhoea and subsequent intestinal catarrh. Two important conclusions force themselves upon us as a result of this study. 1. Summer complaint is not an entero-colitis, as has been hitherto assumed, and as it has been up to the present designated. 2. The treatment with alkalics is unscientific, and not alone that, but positively injurious. In further support of the first conclusion, we have the results of post-mortem examinations of recent date made by so competent an observer as Dr. L. Emmett Holt.* These necropsies demonstrate that- (o) Well-marked lesions are found only at a late period of the disease. Dr. Holt, in concluding his report, says: " We may be pretty certain that at the end of three weeks lesions of a good deal of importance exist in the intestines." (6) The lesions are the results of a catarrh of the intes- tines. As to the origin of this catarrh there can be no ques- tion. It is a well-established fact in pathology that dys- pepsia, vddh its attendant consequences, is the most frequent cause of intestinal catarrh. Ziegler, in his Lehbruch der path. Anat., is very explicit upon this point. He says: " Chronische Katarrhe koinmen namentlich bei anhaltender Einfuhr reizender Substanzen in dem Darmkanal und bei abnormer Zersetzung des Darminhaltes &c. vor." f * Medical News (Phila.), June 9, 1888. f Ziegler. Lehrb. der speciell. path. Anatomic, p. 536. SUMMER COMPLAINT. 49 We have also the evidence of Boas, already quoted above, that in most cases of chronic intestinal catarrh there is anacidity of the stomach (lack of HC1). It is therefore clearly evident that the entero-colitis found at a late date is not the true pathology of summer complaint; it does not in any way constitute the disease, but is itself only a secondary result of a primary patho- logical condition elsewhere located-to wit, the dyspepsia. The correctness of the second conclusion is demonstrated by the results of late physiological investigations. It can not be doubted that the alkaline plan of treatment, which has been handed down to us by a former generation, was based upon an erroneous idea as to the normal condition of the chymus in the intestinal tract. It is not so long since that we were taught that the function of the bile and of the intestinal secretions was to render alkaline, or at least neu- tralize, the acid mass coming from the stomach. Further- more, the fermentative processes, the bacteria (and their nature) that induce them, were altogether unknown. To day, however, we know better. The investigations of Ewald * have shown us that the chymus in the small in- testines is normally acid, and this has been fully corrobo- rated by the extensive studies of Macfadyen, Nencki, and Sieber, already referred to here. We are also familiar with the fermentative processes occurring in the digestive tract and with the nature of the bacteria inducing them. We know that to correct the hyperacidity of the chymus-i. e., to inhibit the fermentative process-it is not an alkali that is required but an acid. The correctness of the views enunciated here is very strongly attested by this: that upon the basis of this ex- position all the numerous contradictions that have hitherto existed between observed facts and accepted theories dis- * Ewald. Klinik der Verdauungskrankh. 4 50 SUMMER COMPLAINT. appear, and all facts, symptomatology, pathology, and therapeutics are united into one harmonious whole. We understand readily why this disease prevails only in the summer months. Why it occurs only in cities. Why the country is exempt. Why it is more common among the poor than among the rich. We understand readily why it is principally hand-fed children that are affected by this malady. The investigations of Einhorn* as to the time required for the digestion of various artificial foods have shown that in hand-fed children the stomach is always taxed to the ut- most to properly perform its function. Now, it is well known to all familiar with gastric pathology that a stom- ach that is always working under a high pressure, as it were, is very easily functionally disabled and very difficult to restore to its normal state. In these children, therefore, dyspepsia is very easily induced, and, owing to the fact that even the blandest of artificial foods is rather hard of digestion for them, difficult to overcome. Why it is that breast-fed infants are but rarely affected, and when so affected quickly recover. We understand readily why removal to the farm, to the mountain, to the sea-shore, is so efficient in curing this dis- ease. The child being removed from the sphere of influ- ence of the aetiological factor heat, is naturally relieved of its effects. The fever ceases ; as a result, hydrochloric acid is again secreted and the stomach soon recovers its func- tional power. That this is the modus operandi is very strikingly illustrated by a case reported by Dr. Boardman, * N. Y. Medical Journal, July 20, 1889. The Time required in the Stomach Digestion of Different Foods in Infants. SUMMER COMPLAINT. 51 of Atlantic City. In this case, despite all the advantages of the sea-shore, the disease continued, because the stomach was kept disabled by the continuous administration of a strongly opiated mixture which the parents had brought with them. As soon as this was stopped the child began to recover.* Why removal even at a late period of the disease is beneficial and effective. We understand readily why the treatment with alkalies has been unavailing; why all the remedies like pepsin, pan- creatin, bismuth, etc., have proved more than useless, and why even antiseptics-e. g., naphthol, sodium salicylate- are of but little benefit. Consequently, why the disease has been hitherto attended by so great a mortality. Why opium, to any extent, is not orly ineffective but positively injurious. We understand readily why any sudden cool spell oc- curring amid the torrid summer weather should be attended with immediate improvement of the children sick with this malady. Why such measures as excursions upon the water for a day (as are arranged by various charitable organiza- tions of New York city) should be attended with striking benefit to the sick children. We understand readily how lavage of the stomach, in- troduced into paediatrics by Epstein f and highly lauded by Seibert, J should prove of benefit, especially if it be aided by enemata of cool water, as seems to be the practice of Seibert. Why rectal injections of cold, * even of ice, water should be beneficial. Cold enemata have a marked cooling effect * Med. Record, Oct. 4, 1890. f Prager med. Wochenschr., Band 45, 1880. | Archives of Paediatrics, April, 1889. * Annals of Gynaecol, and Paid., December, 1890. 52 SUMMER COMPLAINT. upon the organism; this lias been very clearly shown by Dr. Cantani.* The Treatment.-The therapeutic indications are very plain. They may be summed up as follows: 1. Obviation of the aetiological factor, heat. 2. Cure of the dyspepsia. Of course, where removal to the farm, to the mountain, to the sea shore is possible, it is the best measure that can be advised, as it fulfills in itself both therapeutic indica- tions. Where, however, this is impossible, and it is so in the majority of cases, I know of no better way of fulfilling indications than by the wet pack as described in the clinical histories. The advantages of the wet pack are many. It accom- plishes rapidly a removal of the heat effects. It invigo- rates the system. It promotes the cure of the dyspepsia by favoring the secretion of IIC1. It is easily applied, and even the dullest mother learns readily its mode of applica- tion and the indication therefor. Its use can be kept up through the whole hot season, if necessary; two or three or more applications in the morning, two or three in the afternoon, and, if the indication therefor manifest itself, a repetition at night. There is no danger connected with its use; not the least harm can be done. I have never found a mother who did not at once con- sent to its application and who, seeing its beneficial effects, did not carry out faithfully and intelligently the instruc- tions for its use, which were simply to apply the wet pack whenever the child's skin, especially of the head, felt over warm to the touch-a condition usually indicated by marked fretfulness and irritability. In cases of breast-fed infants, entirely or partially, be- * Berl. klin. Wochensehr., No. 31, 1890. SUMMER COMPLAINT. 53 sides the measures above described, I direct certain hygi- enic regulations for the mother-viz.: 1. She shall sponge herself (at least the whole upper half of the body, from the root of the neck to the last rib) with cool water (the ordinary hydrant water suffices) twice daily-on rising in the morning and before she nurses the infant, and at night before retiring. 2. That she shall not nurse the child at any time throughout the day when overheated from cooking, wash- ing, etc. She shall wait until she has cooled off and rested herself. It is a well-established and well-known fact, set forth in numerous treatises, that morbid states affecting the mother have a decided influence upon the milk, and thence upon the child. The importance of these regulations for the wel- fare of our little patients and their rationale will be there- fore readily understood without further elucidation. If the dyspepsia has not been completely relieved by the wet pack, we can aid Nature to a rapid cure by («) medi- cation and (6) regulation of diet. As regards medication, there is only one remedy indi cated, and that is hydrochloric acid. The value of the acid in all cases where the natural secretion is deficient therein (malignant disease excepted) is fully established. Its usefulness in the malady under consideration was already long ago attested by Jacobi.* Lesage f advises an acid as the remedy par excellence for green diarrhoea. It is remarkable to observe how quickly the dyspepsia and its symptoms disappear under the use of the acid. The green or white stools give place to stools of normal color and consistence, all offensiveness disappears, the de- velopment of flatus is inhibited, the appetite becomes good, and the child regains its bright and cheerful look. * Loe. (if. f Loe. tit 54 SUMMER COMPLAINT. Mode of Administration.-The acid may be adminis- tered combined with milk according to Rudisch's formula, which has been detailed above, or it may be given in doses of two drops in a teaspoonful of water every two to three hours at first; later on, as the dyspepsia improves, at longer intervals-three to four times daily. I have found this method very effective in many cases of infantile dyspepsia due to deficient secretion of 1IC1. I generally prefer this latter method, but where the child is very much enfeebled, either from neglect or improper treatment, I should employ Rudisch's method for the first few days, and as soon as the child gained in strength give the acid in the ordinary way. The preparation I employed and still usually employ is the acidum hydrochloric dilutum of the U. S. P. Tn exceptionally severe cases that had already lasted some time-two weeks and over-before coming under treat- ment, the administration of two to three grains of the bis- muth subnitrate (in powder) every two to three hours (for one or two days) proved an excellent adjuvant to the treat- ment above described. For the flatulence and the pain thereby caused, 1 found the rectal injection of a small quantity of a strong decoc- tion of peppermint, or the administration of lac asae foetidae, in half-drachm doses, of excellent service. The regulation of the diet is of the greatest importance in the treatment of dyspepsia. The quantity of food (and 1 usually advise no other than plain cow's milk from a reliable dairy, boiled and kept in a closed vessel, though I have occasionally found some artificial foods and condensed milk well borne) for each feeding should be somewhat less than the normal quantity. The number of feedings must not be beyond the ac- cepted standard; better less, but never more. The child must not take a bottle to bed with it (a very common prac- SUMMER COMPLAINT. 55 tice among people). As it need not be fed more than twice in the night, a fresh bottle should be prepared for it about 11 p. m. and 3 a. m. When milk is badly tolerated in any form, 1 have found nothing better than the decoction of barley, prepared according to Jacobi's* directions. With all this there must be enjoined upon the mother an observ- ance of the most scrupulous cleanliness of all clothing of the child, of its bedding, and of all its feeding utensils. It is almost superfluous to say here that an abundance of fresh air is insisted upon ; the child to be taken out of doors in the early morning hours and later in the evening, if possi- ble to a park. This is of special importance to those liv- ing in rather cramped and close apartments, that are gen- erally more like bake-ovens. Of the many measures otherwise proposed for the treat- ment of this disease, but two require any consideration here-lavage of the stomach and intestinal irrigation. To lavage there are many serious objections. It re- quires the skilled hand of a physician for its application. This alone would be an insuperable obstacle to its general use. The poor can not pay a physician for frequently re- peated and long-continued visits, and but very few physi- cians will burden themselves with such a task where there is no prospect of remuneration. It is true that it has been maintained that one, or at most two, applications suffice for the cure.f Experience, however, has not substantiated this allegation. A moment's consideration will show that it can not be so. The aetiologi- cal factor being constantly active, the pathological condition that necessitated the lavage is reproduced, and such repro- duction certainly makes requisite a repetition of the reme- dial measures. * Loe. cit. f Seibert. Archives of Pcedia'rics, lot. cit. 56 SUMMER COMPLAINT. It is not by any means so harmless and simple a meas- ure as we have been led to believe. In an article on the Treatment of Diarrhoea in Early Life, Dr. H. C. Chapin re- ports the occurrence of fatal syncope from introduction of the tube and distention of the stomach with water. * But lately a case was reported in which longitudinal rupture of the mucous coat near the pyloric extremity and death re- sulted from lavage of the stomach. It does not fulfill the therapeutic indications in the meas- ure requisite. This needs no further elucidation here, for it will be at once apparent to all that, if the views as to the aetiology and pathology of summer complaint as set forth here be correct (and they undoubtedly are), lavage of the stomach is a very inadequate remedy-too inadequate to be employed when simpler and much more effective measures are at our command. As a matter of fact, despite the glowing accounts from Epstein's clinic and the high recommendations of Seibert, lavage of the stomach has found but little favor in the eyes of practitioners and is but rarely resorted to, undoubtedly for reasons as set forth above. Intestinal Irrigation.-I believe I am keeping within the bounds of truth when I say that no such process is at all resorted to (generally); the injection of a little cool wa- ter into the rectum is not intestinal irrigation-not at all as understood by its author. Rectal injections of cold water are not sufficiently ef- fective in any way. The same objection, therefore, holds good here also: They do not fulfill the therapeutic indica- tions in the measure requisite. Taking all things into con- sideration, it can be safely maintained that the plan of treatment as outlined and advocated here is far superior to any that has been devised. It answers thoroughly all the * A. K A fed. Record, June 21, 1890. SUMMER COMPLAINT. 57 therapeutic indications furnished by a careful study of the aetiology and pathology of the disease. It is simple, and, once instructed as to its purposes, any person of ordinary intelligence can carry it out. It is economic, it is cheap, and therefore within reach of the poorest of the poor. Note.-As will be seen, I have made no mention in the section on treatment of sterilization of milk, now regarded as one of the most im- portant factors to recovery. This, from my standpoint, becomes un- necessary. I seek to accomplish and do accomplish, as the cases here set forth show, a restoration of the normal antiseptic qualities of the gas- tric juice. This I hold a far superior method, as it effects not alone the destruction of bacteria introduced from without, but also the inhibition of the activity of the bacteria that normally inhabit the digestive tract. And this superiority is still further enhanced by the knowledge afford- ed us by the valuable investigations of Leeds and Davis, that the nutri- tive value of milk is destroyed by sterilization.* My directions as to milk used for infant food are: That it shall be obtained from a reliable dairy; that it shall be gotten twice daily, morning and evening; that it shall be boiled as soon as received for half an hour in a vessel kept solely for that purpose; that it shall be kept covered, not allowing the cover to be off at any time longer than necessary to take therefrom the modicum of milk needed for each feeding; that it shall be kept in a cool place; if that is impossible, and it frequently is among the poor, I direct that it be put in a large vessel containing cool water, to which a piece of ice is from time to time added. * Am. Jour, of the Med. Sei., June, 1891. ® a REASONS WHY Physicians Should Subscribe The New York Medical Journal, Edited by FRANK P. FOSTER, M. D., Published by D. 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