WATION OF THE LARYNX IN PRIVATE PRACTICE. Results in Seventy-Eight Cases. BY CHARLES M. WHITNEY, M. D. Reprinted from the Boston Medical and Surgical Journal of October 5, 1893. BOSTON: DAMRELL & UPHAM, Publishers, 283 Wathington Street. 1893. INTUBATION OF THE LARYNX IN PRIVATE PRACTICE: RESULTS IN SEVENTY-EIGHT CASES.1 BY CHARLES M. WHITNEY, M.D. During the seven years that intubation has been before the medical profession, evidence has been slowly accumulating as to its value in the treatment of mem- branous obstruction in the larynx. It was but natural that an operation of such apparent simplicity and free- dom from danger should be received with enthusiasm as a substitute for the older and severer operation of tracheotomy. The experience of many observers in different parts of the world has placed us in a position to-day to calmly judge of its merits as an operative procedure. The frequency and fatality of laryngeal obstruction in children is so great that a clear understanding of the elements which guide us in a selection of one or the other operation is of the greatest consequence. The majority of the reported cases of this operation have been performed in the large metropolitan hospi- tals, where the cases could be watched with the great- est care and where careful nursing was available. While this is of value it also follows that the children are usually taken to the hospital only after every method has been exhausted to expel the membrane and when suffocation is imminent. The resulting weakened condition materially affects the outcome of either operation. Where one can watch the child from the onset of the symptoms, an earlier operation is possible, and the strength can be saved to fight the disease. 1 Read before the Surgical Section of the Suffolk District Medical Society, April 5, 1893. 2 It is in this class of cases that I desire to present the result of five years' experience in the performance of laryngeal intubation. Every practitioner of large experience has met with cases where a child suffering with membrane in the larynx, was growing steadily worse, and where the parents would not permit it to be removed to a hos- pital where an intelligent selection of one or the other method could be made, nor would they submit it to the cutting operation. In this class of cases, there was nothing for the physician to do but to watch the child slowly suffocate, until the originality and patient inves- tigation of Dr. O'Dwyer placed at his disposal a method of relief. It is here that intubation occupies a field peculiarly its own and no comparative statistical tables can show the number of lives which have been saved by it. My own experience has fully substantiated this statement. Not the slightest objection has ever been made to the operation or to a re-intubation when the tube has been coughed out. A case illustrating this fact came to my notice some three years ago through the kindness of Dr. Record, of Wollaston. A child of three years was attacked by diphtheria and rapidly developed symptoms of laryn- geal obstruction. An operative relief was recom- mended and a surgeon was summoned to perform the operation. At the last moment the mother refused to permit the operation. As no tubes were available I was summoned to do an intubation. The operation was easily done and the child completely relieved. The relief continued for two days, when it perished from septic poisoning. Intubation, then, has for its first advantage availa- bility. Any one who has watched a child with the disease 3 in question, and has noted the labored breath, the rest- less tossing and gradual change in color, must agree that both exhaustion and carbonic-acid poisoning are very important elements in deciding the result of either operation. In the beginning this change is so gradual that the parents are loth to believe that a little delay will not result in an amelioration of the symptoms, and thus postpone an operation which is so severe as tracheot- omy. An operation so simple, so painless and blood- less as that under consideration is readily consented to and hours of suffering are saved the child and the strength is by just so much the greater. This, then, is the second advantage of intubation that it can be done early. To safely perform a trache- otomy at the home of the patient, at least one trained assistant is needed and one man with steady nerves to manage the anaesthetic if one is used and to steady the head. Intubation, on the other hand, can be performed by one moderately skilful with aid of two persons of ordi- nary intelligence, one to hold the child, the other to manage the gag. Several times I have inserted a tube with only the parents to help me, and in one instance the original operation was done on a child of thirteen months with the aid of two nervous women. In such a case the most ardent advocate of tracheotomy would find its performance rather difficult. By these comparisons I do not desire to convey the impression that tracheotomy is always extremely diffi- cult and intubation extremely easy, for it is far from being true. Any one who has intubed a young child, gasping for breath, whose small pharyngeal space pre- vents or prolongs free manipulation and in whom the attempt to enter the larynx produces an alarming de- gree of cyanosis, will soon realize that any operation to 4 relieve the condition cannot be simple and easy, but is fraught with the gravest anxiety and responsibility. For this reason no operation should be done without a careful consideration of all the elements in the case. Neither should be done as a routine procedure, but each performed in suitable cases. Certain other self- evident advantages belong to intubation : freedom from shock and haemorrhage, absence of new infecting sur- faces and resulting cicatrices, rapidity of performance, the opportunity of breathing air warmed by the natu- ral passages. My own experience in this operation comprises its performance in 78 cases, all in children under ten years of age. Divided according to age there were: Cases. Recoveries. Under 1 year 2 0 1 to 2 years 12 3 2 to 3 years 18 6 3 to 5 years 20 5 5 to 10 years 26 12 As regards sex, 48 were males, 30 females; of these, 26, or 33 per cent., recovered. As these cases were nearly all seen in consultation with various physicians, they have presented a wide variation as to the time the operation was done. In some it was done early, in others very late, and taken altogether they represent a fair average of cases which one meets both as regards severity and time of opera- tive relief. Earlier operative relief would have saved even more lives. These cases have been of the greatest interest on account of their occurrence in such varying surround- ings. In some the most skilful nursing was available, in others only the simplest attentions were given. In all, the result was so relatively satisfactory that I de- sire to consider somewhat in detail the elements which 5 have a great deal to do with the success of this opera- tion. The first important question which arises is, When has the proper moment arrived for operative inter- ference in these cases ? I am sure there can be no difference of opinion as to the advantage of early re- lief. When a child suffering with diphtheria develops a croupy cough with hoarse voice and harsh respira- tion, and when in spite of the usual treatment has ob- tained no relief, but is gradually growing worse, the intercostal, supra-sternal and supra-clavicular spaces are beginning to retract, then no advantage is to be gained by longer waiting. This may take a longer or shorter time, but the per- sistent and increasing retraction is one of the most important symptoms, and longer waiting is at the cost of the child's strength. The steady progression of the disease with no intervals of relief, together with its gradual onset, serve to distinguish it from catarrhal laryngitis, or spasmodic croup, especially in those cases where no exudation is present upon the fauces. The instruments which are familiar to nearly every one to-day, consist of the introducer, the extractor and gag, varying sizes of tubes with their obturators. It has been a matter of surprise and regret to me, as doubtless it has to many others, to find the instru- ments so carelessly made that they are often unsafe for both operator and patient. The original gag de- vised by Dr. O'Dwyer is difficult to manipulate, and has been replaced in most of the cases, sold now, by a straight one which works with a spring and ratchet. This, for example, is too light, the blades are made of soft iron, the spring and ratchet too weak, which allow the blades to be forced together, or to be snapped quickly when touched by the nervous hand of an un- trained assistant. Twice, with the gag furnished in 6 my first set, were the blades forced together while in the mouths of three-year-old children. In these cases the ratchet held well enough but the soft iron of the blades permitted their closure from the strong press- ure of the jaws. The danger of diphtheritic infec- tion from a wound in the finger is too great to allow us to consider such a matter lightly. The shank in the introducer is not strong enough, and frequently a bend is produced which interferes with the sliding of the fork which pushes the tube from the obturator. The thread which unites the obturator to the intro- ducer wears away so rapidly that after a short time the tube turns half-way round when screwed on tightly. Experience at the City Hospital has shown that this part may even break - a very undesirable accident. I have considered the tubes to be fairly well made, aside from occasional deviations from the correct shape, but a recent experience has taught me that they, too, have the same faults of careless and poor workmanship. In one of my most recent cases, after removing a five-year-old tube from a dead child, a matter of no difficulty whatever, I was surprised to find an opening had been made in the posterior wall of the tube just below the collar, which was produced by the moder- ate pressure of the jaws of the extractor. What the effect of the accident would be in extracting from a living child is at once apparent. The walls of this tube w'ere as thin as paper. I have attempted to overcome some of the disadvan- tages of these instruments by certain slight modifica- tions. The obturator is so easily removed from the tube when the latter is held in position by the finger, after introduction, that I have omitted the apparatus for re- moving it and have had the shank made larger and stiffer, and the thread hardened to prevent wearing. As the sizes below two years will not admit a large 7 thread I have two shanks which are easily interchanged. In the original introducer, the angle made by the shank and obturator is a trifle more obtuse than a right angle. As the larynx is directed slightly backward, with this instrument the handle must be elevated so that the tube will easily enter it. I have made this angle a trifle more acute than a right angle so that the tube will be directed forward and more easily enter the larynx. The joint in the obturator should be carefully oiled to prevent rusting and a possible breakage when removing it from the tube when in the larynx. To perform this operation quickly and with as little shock as possible, certain precautions are of value. The child's arms should be placed by its sides and a blanket should be firmly wrapped about it leaving the neck as free as possible. In young children two safety pins will make this se- cure, but in older ones a bandage should be added. If this is not thoroughly done, the child will seize the thread and pull the tube out in the struggle immedi- ately following the introduction. A firm, straight- back chair should be placed so that there is plenty of space about it. The person who is to hold the child should be seated squarely on this chair, and the child placed in his arms, and firmly held. The position which I have found most convenient and which gives the most working space in the pharynx is one midway between the upright and reclining, the head resting on the bend of the elbow of the person who holds the 8 child. Displacement of the gag by the shoulders strik- ing it, or the hand of the assistant, is thus avoided. The gag is then inserted far back in the mouth, tak- ing care to open it widely or it may slip out. The as- sistant then holds this, and also steadies the head if no other person is available to do this. The operator, standing opposite the child, passes the left index finger well back into the pharynx and on bringing it for- ward the epiglottis is quickly seized and retained. The finger and metacarpal joint of the operator should be well covered with adhesive plaster to pre- vent injury in case the gag slips. The threaded tube is then introduced precisely on the median line, the handle being at first depressed and then quickly ele- vated so that upon entering the larynx the tube is di- rected slightly forward. If the case is an easy one the tube slips quickly into the larynx, and as it is nearly in position the finger is pressed firmly upon the collar of the tube and the obturator removed. It frequently happens, however, that after the tube enters the larynx it meets with some obstruction, the child stops breathing, gives a gasp and the tube slips in easily. This is caused, I imagine, by the ap- proximation of the vocal cords, which upon separation permit the entrance of the tube. The presence of the tube in its proper position is determined by two facts: first, the peculiar dry cough, which if once heard is sufficient to make one fairly sure ; and second, by the presence of a septum between the finger passed into the oesophagus and the tube in the larynx. If this is felt its position is assured. With finger resting on the collar of tube the thread, which should be waxed to prevent sticking together, can be quickly removed and the operation is completed. The relief in most cases is immediate. The child, after coughing a short time, breathes quietly, the face 9 loses its drawn and anxious look, and for the first time in many hours goes quietly to sleep. This quick tran- sition from the sufferings of severe dyspnoea to peace- ful slumber is one of the pleasantest features of this operation, and it is one not so constantly seen after tracheotomy in my experience. While this is by far the most common result after this operation, it must not be forgotten that frequently certain variations are found, and (rarely, fortunately,) other grave emergen- cies arise, which one should always be prepared to meet. Among the former we find introduction difficult from enlarged tonsils, from swollen epiglottis and ary- epiglottic folds, and from a larynx small and deeply placed. In all these the first attempt may fail, but it rarely fails to dislodge a considerable quantity of tena- cious mucus, or even membrane, which clears the way for the second attempt. Not more than eight to twelve seconds should be allowed for any one attempt and frequent short at- tempts are far less productive of shock than a single prolonged one which should never be made. Among the latter, we have the one possible danger of this operation, one fortunately so rare that it does not deter us in the least from performing it. That is, the danger of the membrane blocking the end of the tube, either by being pushed down and folded up, or by its presence below the lower end of the tube. In these cases the operation gives no relief, and the child may stop breathing. The tube should be instantly removed and the cough which follows the procedure may dislodge the mem- brane, and render a second attempt possible. When this does not occur an immediate tracheotomy is the only alternative and it must be done quickly. The outcome of these cases is usually fatal. The more strictly the tube is kept in the median line the 10 less liable is it to dislodge membrane from the sides of the larynx and carry it before it into the trachea. As the tube reaches to within a half-inch of the bifurcation, it is not often that membrane is present in large enough amount below this to cause trouble. In contrast to the number of deaths which occur from shock and haemorrhage during tracheotomy, in- tubation has nothing to fear from a comparison of possible accidents. It not infrequently happens that during the cough- ing which follows its introduction the tube may be ejected. One size larger should be selected and will usually be retained. If the tube is coughed out later in the progress of the case the same rule should be observed. There is usually in these cases an interval of relief, long enough for the operator to reach the patient, and after the first twenty-four hours it occasionally happens that its re-introduction is unnecessary. In general, I have found that the tubes were a little small, and that the relative size of the child was the best guide in the original selection of the proper size of tube. The after-treatment of these cases requires patient and unremitting care. Children have been, and will be, lost from lack of attention to certain essential de- tails. Where it is possible, the care that a trained nurse can give, will greatly aid in carrying out these details. To my mind the most important weapons we have to fight this dread disease are : abundant stimulation and nourishment; the free use of steam, and mercurial medication locally and internally. The child must not be wakened from its sleep, how- ever long it may be, for any purpose whatever. After wakening, however, if it is given some thin liquid and be allowed to take it in the usual upright posture, a 11 violent attack of coughing ensues from lack of complete closure of the epiglottis over the tube. It does not take many such attacks to discourage a child from taking anything. If, on the other hand, a semi-solid, like ice-cream, thick cream or the like be given the coughing is much lees, or none at all, and the child soon adapts itself to its new condition and will soon attain a certain facility of swallowing which will permit even liquids to be swallowed with comparative ease. The most important advance in the treatment of these children was made when Dr. Casselberry, of Chicago, showed us that a child lying down so that the pharynx was lower than the larynx could swallow with the greatest ease. When this position can be maintained the battle, so far as nutrition is concerned, is half won. This position, in my experience, is very difficult to get children to submit to, but by patience and firmness considerable can be done in this direction. In young children a nursing bottle is a great help and in older ones a tube through which they can take liquids when lying down. As a rule, the younger the child the more difficult is the swallowing. Among the articles of food from which a selection can be made the following are of the most value - cream, ice-cream, egg-nog, bread and milk, blanc- mange, rennet, oysters raw or stewed, bananas and cream, shaved-ice, eggs in various forms, milk, milk- punches, beef-meal, peptonoids solid and liquid, Valen- tine's extract, bovinine, custard, Charlotte Russe, corn- starch pudding, sherbet, Roman punch, jellies of various sorts, thick gruels. Rectal feeding has proved very disappointing, the rectum soon becomes intolerant of even the blandest injections, and there is more or less exhaustion result- ing from the necessary manipulation. Before we un- 12 derstood the proper method of feeding it often became necessary, now, it is seldom required. If one wishes to use this method, peptonized milk, with the addition of peptonoids liquid or powdered, gives the most satis- factory results. Half-hourly administration of nourish- ment during the day is advisable unless the coughing is extremely troublesome when hourly administration may be substituted. I u obstinate cases where other means have failed, re- sort may be had to feeding through a tube. The child is held in the arms, a gag inserted, and a soft catheter passed into the oesophagus and the milk poured into the stomach. The procedure is easily accomplished after a little practice and any nurse can quickly learn to do it. About four ounces should be used each time, with some form of stimulant. The free use of alcoholic stimulants in these cases serves to most effectually fight the septic poisoning of the disease. It seems impossible to over-stimulate these cases, enormous amounts are taken without Hush- ing or other evidences of too great an amount ingested. For a child of three years, from a half to a tablespoon- ful of whiskey or brandy can be safely given hourly to be increased or diminished as the case demands. By combining it with milk it is more easily taken and is less liable to cause coughing. When a child objects strongly to these two, champagne may be substituted. In order to loosen the tenacious secretions steam is one of our most valuable agents. I have given up entirely the various steam atomizers, they are always untrust- worthy, a cool vapor is produced and they are not available in all cases. I have found the most practical method was to utilize the ordinary tea-kettle which is always at hand. To the nose of this a rubber tube is at- tached and conducted to the bedside of the patient. The objection which 1 found to this was that so large 13 a calibre of tube was required that much of the steam was lost by condensation. To obviate this I have availed myself of a device of steam fitters, which is shown in the diagram, called a " reducing coupling." By means of this a large tube may be used on one side and a small one on the other. They can be ordered from any plumber, by simply designating three-fourths inch and one-eighth inch nipples and a three-fourths- inch reducing coupling. The cost is slight, about thirty cents, and the convenience great. If a large volume of steam is to be used, the child's bed or crib should be enclosed in a sheet-tent and the steam in- troduced beneath it. Nipple (J in.). Reducing Coupling. Nipple (f in.). Gas Tip. Among the various medicinal agents which have been used to prevent the formation and extension of membrane in the larynx, mercury occupies the first place. Children suffering from diphtheria exhibit a remarkable tolerance to this drug. Doses which would salivate an adult are taken with perfect immunity by them. To accomplish anything, large doses must be used. In a child of three years it is well to begin with one-sixtieth of a grain of corrosive sublimate every hour, in Fairchild's essence of pepsin ; and this should be increased to one-thirtieth of a grain every hour, if ex- udation on the pharynx is increasing, or if extension below the tube is taking place. I have occasionally, in severe cases, given one-sixteenth of a grain every hour, and no toxic symptoms were produced. In one 14 case, which was treated under conditions particularly favorable for careful observation, being the child of a physician, during the eight days of the laryngeal in- vasion six grains of corrosive sublimate were taken in hourly doses of one-sixteenth of a grain. Absolutely no discomfort was noticed. The symptoms of the toxic action are quickly detected by abdominal pain, nausea and vomiting, and by loose greenish stools. Even more remarkable is this toler- ance as shown in the results of the method known as " calomel fumigation." A half-drachm of calomel is sublimed under a tent, and the child breathes this without injury, and with apparent benefit, while the nurses are usually mildly salivated by the slight amount of vapor which escapes from the tent. This method seems to promise good results in the treatment of this disease, but I have not as yet had a good opportunity to try it. I have seen several cases of beginning laryngeal obstruction which have subsided without an operation where steam and mercury had been freely used, and in these cases the improvement seemed to be due to the mercury. In three cases, I have seen a fresh ex- udation form on the tonsils where it had disappeared after the use of this drug, and when from fear of poison- ing its use had been discontinued. Upon again using it, the exudation promptly disappeared. If enough similar cases can be observed, it will materially aid us in deciding as to its value. From my experience so far I should hesitate to treat diphtheritic croup without it. In addition to the drug internally, a spray of corrosive sublimate (1- 2,000) is of service, used both in the nose and throat. I have given up the use of local applications if a child objects very strongly ; for the exhaustion more than balances any benefit to be derived from their use. 15 Among other agents which are of service are digitalis* if there is defective action of heart or kidneys ; also iron and peroxide of hydrogen in very septic cases, applied by spray or swab in the strength of one to four. The temperature of the room should be moder- ately elevated, 70° to 74°, and the air should be fre- quently changed to ensure plenty of fresh oxygen. In favorable cases the child soon becomes reconciled to the presence of the tube, breathes quietly but rather more rapidly than normally, has now and then a severe paroxysm of coughing as it raises masses of tenacious mucous membrane through the tube, and often sits up in bed playing with its toys. More or less cough is constantly present, chiefly for the raising of the large quantities of secretion which come through the tube, but which being swallowed are not so easily noticed, and do not require the care that the secretion from a tracheotomy tube does. In fatal cases the child may gradually sink, the respiration becoming more frequent and the pulse weaker, and death may occur within the first ten hours. The shortest interval that I have observed has been eight hours. In many cases no unfavorable symptoms arise until the third day, when the temperature begins to rise, the respira- tion becomes rapid and somewhat labored, and the child dies from the resulting broncho-pneumonia in twenty- four to forty-eight hours. In the majority of fatal cases death occurs before the fourth day ; and if they pass the third day without the development of these symptoms we can feel tolerably sure of a favorable outcome. The longest time that has elapsed in these cases which I have met with has been six days. If sudden occlusion of the tube occurs, a rare accident in the experience of those who have seen the largest number of these cases, the only resource is to use the method mentioned by Drs. Prescott and Goldthwaite, 16 as used by a nurse at the City Hospital, which was to raise the child by its feet, wheu the tube may be moved enough to dislodge the obstructing membrane. Dr. O'Dwyer suggests the value of firm pressure on the chest in cases of this kind, in the hope that the air thus compressed may force the tube out. It seems reasonable and deserves a trial. The prognosis in these cases is a matter very difficult to estimate. Cases which look favorable will develop the most serious symptoms, and die; while those who have apparently no chance will pull through. In the cases which have come under my notice there were two well-marked classes: The one, where there was or had been, little or no exudation upon the fauces, glandular enlargement or nasal discharge. This class of cases is often mistaken in the beginning for ordinary follicular tonsillitis, and I have in several cases noted the history of an attack of follicular tonsillitis perhaps a week before the onset of the laryngeal symptoms. Too great care cannot be taken in clearly establishing the diagnosis in such at- tacks ; and in the present state of our knowledge I do not believe it can be done absolutely until a bacteri- ological examination has been made. The other class has the ordinary symptoms of diph- theria ; the fauces are more or less covered with mem- brane, the glands are enlarged, and more or less nasal discharge is present. In fatal cases, the cause of death in the first class is from bronchial extension, and in the latter from septicaemia. From the fourth to the sixth day the tube should be removed. It is often difficult to decide just when this should be done. In general the younger the child the longer the tube is required ; and it is also true that the shorter time a tube is in the less the liability to 17 to produce any ulceration from pressure, or to produce an irritation in the larynx which may be sufficient to require its insertion even in the absence of membrane. In cases where there is an exudate on the fauces, the disappearance of this is a valuable guide in deciding this point. If the temperature is normal or nearly so, the respiration easy and not increased in frequency, and if, in other words, the pathological process is at a standstill, the removal of the tube is advisable as soon as possible after the fourth day. The operation of removal of the tube is far more difficult in my experience than its introduction. If any one doubts that it is difficult, let him attempt to localize the opening in a small tube, where the pharynx is small, and where every thing is covered with slip- pery mucus and feels alike, and after having done this successfully to attempt at the same time to hold the epiglottis out of the way while the point of the ex- tractor is inserted into the tube. Far more practice is required and less is available (for removal from a dead child is quite another matter than from a living one), in the extraction of a tube than its introduction. The instrument designed by Dr. O'Dwyer has the marked disadvantage that it does not hold the tube firmly enough, so that when partial removal is accom- plished the tube slips off. Dr. Nichols of the City Hospital has skilfully worked out the mechanical prob- lem, and has devised an extractor so excellent that any trouble in this direction will be avoided. Two points should be kept in mind in removing a tube : keeping the handle depressed as the tube is raised from the larynx, and also avoiding too great pressure down- ward in difficult cases. If there is much difficulty, it is safer to have an assistant place a thumb against the trachea where the lower end of the tube can often be easily felt, and by pressure upwards a greater firmness 18 is given which renders a pushing into the trachea im- probable. If the tube is to be reinserted, the dyspnoea may at once recur, but in most cases not for four or five hours ; after twelve hours they are usually safe. A most in- teresting exception to this was seen in a case which I saw with Dr. Francis Murphy, of Roxbury. A child of eight and one-half years was intubed on November 27, 1890. The case progressed favorably, and the tube was removed on the sixth day. No re- currence took place until December 7th, when a second intubation was necessary. Removal was again accom- plished on the fifth day, December 12th, and the case continued to perfect recovery. This is the only case of the kind I have ever seen, and the only one in which I have been obliged to reinsert a tube. After removal, the same treatment should be kept up for twelve hours. Children, from a stiffness of the epiglot- tis swallow little if any better for that length of time than when the tube is in position. Steam can usually be omitted on the second day, and the bichloride dimin- ished rapidly till it is omitted on the fourth day. From the foregoing considerations it will be seen that intubation is an operation especially adapted to private practice. It is always available, can be done early, is both painless and bloodless. In a majority of cases it relieves the dyspnoea perfectly and leaves no after-effects. It saves as many lives as tracheotomy, and many more where the latter could not be per- formed. On the other hand, it cannot be selected in all cases. It is not advisable where the tonsils are so large that they prevent the necessary manipulation, or where the fauces are full of putrid debris and the epi- glottis immovable from the destructive action of the disease. Nor is it advisable in cases at a great dis- tance on account of the possibility of the tube being 19 coughed out and the dyspnoea recurring before the op- erator could reach the patient. . If one is called upon to operate upon his first case of croup, it would be wiser to select tracheotomy; but after a certain familiarity with the feel of the parts has been attained, which largely does away with the awkward and even brutal attempts seen in the begin- ner, I am sure that intubation would nearly always be selected. The operation is not and can never be an easy and simple one; extremely so at times, at others it is so difficult as to perplex the most skilful intubator. When its advantages have become thoroughly known, I am sure that many lives will be saved which now are lost, and that the profession will feel an increasing sense of gratitude to the skilful physician who devised it, Dr. Joseph O'Dwyer. S. J. PARKHILL 4 CO., PRINTERS BOSTON