OVARIAN TUMOR COMPLICATING PREGNANCY. Read before the State Medical Society by title BY E. E. MONTGOMERY, M.D., Professor of Didactic and Clinical Gynaecology in the Medico-Chirurgical College, Obstetrican to the Philadelphia Hospital, etc. \Reprinted from the Philadelphia Medical Times for July 23, c88y.~} OVARIAN TUMOR COMPLICATING PREGNANCY. THE field of ovarian disease has been so often gleaned that the hasty ob- server may deem it impossible to cull any- thing new therefrom. While I do not, in this paper, make any pretence to special originality, I hope to be able to present what experience teaches to be the most successful method of treating " Pregnancy complicated by Ovarian Tumor." It may be questioned whether this com- plication is frequent enough to render the subject of sufficient importance to occupy the time of this scientific body. Its fre- quency may be appreciated when I am able, from a very cursory investigation of the literature, to present tables of over one hundred and fifty cases. Ovarian disease does not preclude the possibility of conception so long as the ovaries contain healthy ovarian stroma. In Spencer Wells's first one thousand cases of ovariotomy over two hundred children have since been born. A woman upon whom I did ovariotomy in the Phila- delphia Hospital in 1879, whose second ovary contained so many cysts that its removal was debated, has been treated in the same institution for abortion. Schroe- der, with the knife, and Pippingskoeld, with the galvanic cautery, have destroyed the cystic tissue of the second ovary, and the woman subsequently became pregnant. Indeed, rare instances, have shown that the removal of the ovaries is not an abso- lute safeguard against conception. In such cases there are undoubtedly rudimentary masses of ovarian stroma or supplemen- tary ovaries. This probability of subsequent concep- tion is a strong argument for the preserva- tion of the second ovary during the period of sexual activity. Instead of complete extirpation, we should follow the course of Schroeder and Pippingskoeld. The investigations of Jetter have shown that any form of ovarian cyst may compli- cate pregnancy. Of his collection of one hundred and sixty-six cases, ninety-seven were cystomata, thirty-seven dermoid, eleven carcinomata, and twenty-one un- certain. In a majority of the cases the tumor had existed for a length of time before pregnancy. It is frequently asserted that owing to the pelvic hypersemia consequent upon preg- nancy the growth of these tumors is greatly accelerated. This growth, however, is probably more apparent than real. The great distention and distress are due to the natural growth of the tumor, plus the accompanying development of the uterus. Wernich not only accepts the accelerated growth as an established fact, but asserts that benign cysts, during pregnancy, are more likely to take on malignant action. Ruge explains the latter by claiming that the malignant element was originally pres- ent. The dermoid cysts, from their smaller size, are most frequently found in the true pelvis. The situation and size of the tumor are of marked significance in determining the prognosis. Of seventy-five cases, includ- ing those of Playfair, the tumor was found in the recto-vaginal septum in forty-one, on the right and left sides each five times. When small, the growths may frequently be overlooked, and the hinderance to de- livery remain undiscovered or be ascribed to pelvic narrowing. Grigg's post-mortem researches in puerperal septicaemia render it probable that many cases of this disease are due to injury of unrecognized ovarian tumors during parturition. The diagnosis of the coexistence of pregnancy and ovarian tumor is of the greatest importance, and oftentimes a dif- ficult problem, but the limits of this paper will not permit of its discussion. The mortality of ovarian tumor compli- cating pregnancy treated by the expectant plan is frightful. In the seventy-five cases culled from literature, thirty-one, or forty- one per cent., were fatal, while but twenty- two children, or twenty-nine per cent., are quoted as having been saved. The mater- nal mortality differs but little from that given by Litzman,-maternal, forty-three per cent. ; foetal, eighty-three per cent. Such a death-rate urgently demands the investigation of other plans of treatment. When we come to the consideration of ovariotomy during pregnancy, we find far better results. In the accompanying table of sixty-one 2 OVARIAN TUMOR COMPLICATING PREGNANCY. cases, but seven, or less than eleven per cent., were fatal; thirty-nine went to full term, or reached the period when the child became viable. The comparison of the results of ovariotomy (maternal mortality twelve per cent., foetal mortality thirty- five per cent.) with those of the expectant treatment (maternal mortality forty-three per cent., foetal mortality eighty-three per cent.) unquestionably demonstrates the value of the former. It is seen that the presence of pregnancy does not materially enhance the danger of ovariotomy. Fur- ther, it is rendered prominent that after performing ovariotomy the prognosis is extremely favorable for mother and child. Finding that ovariotomy can give such good results, it remains then to be taken in consideration in each individual case. The following points naturally present themselves for discussion : 1. Is ovariotomy the most secure and best proceeding for the removal of the complication ? 2. Shall one in all cases do ovariotomy? 3. When is the most favorable time for its performance? Those having large experience, as Spen- cer Wells, Tait, Cauchois, Olshausen, and the late Carl Schroeder, unite in commend- ing ovariotomy as the most desirable pro- ceeding. Most agree that it should be done at once in recognized ovarian tumor during pregnancy, on account of the dan- ger of rupture of the cyst, twisting of the pedicle, exhaustion of the patient from the great abdominal distention, the possi- ble complication of labor from the pres- ence of the tumor, and the greatly in- creased mortality where ovariotomy is required during the period of puerperal convalescence. Its early performance is especially important when we take in con- sideration that Cohn has proved every sixth tumor to be probably malignant. With the experience before us of the late Carl Schroeder, of fourteen cases and no deaths, Spencer Wells and Tait each eleven cases with one death each, the presence of pregnancy should hasten rather than retard the performance of ovariotomy. The sixty-one cases of the accompanying table, with a mortality of eleven per cent., show that, while pregnancy does not im- prove the prognosis, it certainly does not make it worse. Next to ovariotomy, tapping has always been more or less employed. Our first table will show that it is just about as dan- gerous and as free from danger as ovariot- omy, with the disadvantage that it is not a radical operation. It is still further un- satisfactory in that it increases the dan- ger of subsequent ovariotomy, and that there is greater danger of wounding neigh- boring organs. Artificial labor is now but little performed, for the reasons that it does not preclude the necessity of ovari- otomy and that it diminishes the chances of the foetus. Abortion and tapping do not preclude ovariotomy, but rather augment the necessity of its performance under un- favorable circumstances. If, then, in the complication of ovarian tumor with preg- nancy, ovariotomy gives clearly better re- sults than either the purely expectant treatment upon the one hand or tapping and abortion on the other, it is the most secure and best proceeding. But shall we do ovariotomy in all or only in isolated cases ? The answer to this question is the fol- lowing : one must, in all cases in which ovarian tumor has been diagnosticated, do ovariotomy, because- 1. Ovariotomy is unavoidable, and the prognosis is not made worse by the exist- ence of pregnancy. 2. The labor and convalescence with the tumor offers a far more unfavorable prog- nosis than without it. 3. Many tumors are malignant, al- though we cannot certainly so diagnose them; and it is difficult to say how far the spreading of the malignant element is favored by pregnancy and the resorption in convalescence. The most favorable period for operation, as recognized by all operators, is during the first half of the pregnancy. In the last months, the increased hyperaemia and engorgement of the broad ligaments ren- der it less favorable. Then, too, there is more probability of the convalescence be- ing complicated by premature labor. The experience of a number of operators, as quoted in the table, shows that the opera- tion can be performed in advanced stages of pregnancy with good results. The case of Pippingskoeld, in which it was per- formed during labor, is eminently encour- aging. My own experience (limited to one case) has led me to question whether, in the last stages of pregnancy, it would not be better to follow the excision of the ovarian tumor OVARIAN TUMOR COMPLICATING PREGNANCY. 3 by removal of the contents of the uterus through Caesarean section. The history of the case to which I allude is as follows. April 4, 1886, I was called in consultation with Dr. George Mays, to see Mrs. N., aged 24 years. She had been married less than a year, and had ceased to menstruate August 15, 1885. The menstrual function had become estab- lished during her thirteenth year, and,while regular, had always been scanty. For the past year she had had considerable distress and sense of weight in the pelvis, with occasional attacks of difficult micturition amounting, at times, to retention. The sensation of weight was greatly increased after marriage, but very naturally was. at- tributed to pregnancy. At the date men- tioned she believed herself in labor. She was complaining of severe pain, and the doctor informed me that upon digital exam- ination he could not find the os. He had also unsuccessfully attempted to catheterize her. Inspecting the abdomen, the uterus was seen distending it as high as the ensi- form cartilage; below, reaching nearly to the umbilicus, was a second spherical tu- mor which fluctuated and was evidently the distended bladder. By the vagina was felt a moderately elastic mass, filling up the curvature of the sacrum and reaching to the symphysis in front. I first supposed it a case of pregnancy in marked ante- flexion of the uterus, in which we would find the os uteri situated high up ; pushing the finger well up forward, I could reach the cervix just above and behind the sym- physis. The os was undilated. The press- ure of the cervix upon the neck of the bladder was the cause obstructing urina- tion. By means of a male catheter nearly two quarts of urine were drawn off. The pelvis was filled up with a smooth round tumor which had pushed the bladder and uterus completely out of the pelvis. A rectal examination disclosed some projec- tions from the cyst, showing that it was not a single cyst, although unmistakably of ovarian origin. Failing in the effort to push the tumor up while the patient was in the genu-pectoral posture, we were con- fronted by the necessity of relieving her of its presence to permit the expected de- livery. She had now about reached the eighth month of pregnancy. Should we induce premature labor ? This would not be possible unless the tumor was simulta- neously reduced. Tapping was thought unwise, for the reason that the majority of these intra-pelvic ovarian growths are either dermoid or multilocular cysts, with very viscid contents. Our examination had shown the growth to be multilocular. The escape of its contents into the pelvic cavity would insure the development of peritonitis, and this would be still further aggravated by the bruising of the sac in the passage of the foetus over it. Accord- ingly, it was thought better to do ovariot- omy. After thorough disinfection of the room, assisted by Drs. Mays, Warder, Eshleman, and West, the operation was performed, April io, 1886. Beginning one inch below the umbilicus, an incision five inches long was made towards the symphysis. The left hand was passed between the left abdominal wall and uterus, behind and below the latter, until the cyst was reached. A small cyst projected above the pelvis and ruptured under the pressure of the hand. Dr. Mays introduced his hand into the vagina to facilitate the delivery of the larger cyst. It also ruptured under the pressure. The sac was raised up, and, having its origin on the right side, it was passed behind the uterus to the opposite side. Its pedicle was ligated with the Staffordshire knot, the tumor removed, the abdomen carefully cleansed, the wound closed with silk sutures. The wound was dressed with sublimated gauze and absorb- ent cotton. The operation was completed in forty minutes. The left ovary presented a cyst the size of an orange, but it was thought best not to remove it. The night following the temperature was 102.20, but soon subsided, not again reach- ing 1020, becoming normal on the fourth day. On the seventh day the sutures were removed and the dressing renewed. The central portion of the integument was un- united, the sutures having cut out. This was supported by adhesive plaster. A few hours later labor set in. This occurred during my absence. Dr. Mays, seeing serum oozing from the abdominal open- ing, applied the forceps and delivered a strong, healthy child. As the forceps were applied with the patient lying upon her back in the centre of the bed, the vulvar orifice was necessarily considerably lacerated. When I saw her about an hour after the labor, she was very much ex- hausted and had lost considerable blood. The second day following the temperature OVAR 1AN TUMOR COMPLICATING PREGNANCY. 4 began to rise, the lochia became offensive, the abdominal wound opened, and offen- sive serum was discharged. Intra-uterine injections were given, and the abdomen washed out with chlorinated soda and lis- terine, but despite all our measures the septic symptoms continued, and death occurred April 24, two weeks after the operation. It has since been a regret that while the abdomen was open I did not remove the contents of the uterus and close the uterine wound with sutures, after Sanger's method. I am encouraged to believe such a course would have been suc- cessful from those cases of Wells and By- ford in which the uterus was injured during ovariotomy and emptied of its con- tents. In Byford's case the pregnancy had reached the eighth month. My patient showed no septic symptoms until after the delivery, and by the course suggested this source of origin would have been avoided. Cases of Ovarian Tumor complicating Pregnancy Treated. Expectantly. Reference. Position of Tu- mor in Pelvis. Left to Natural Powers. Punctured. Embryotomy. Pushed above Brim. Turning. Forceps. Rupture of Uterus. Results. Remarks. Mother. § I Hewlett, Med.-Chir. Tr., vol. vi. Recto-vag.pouch. I ... D. D. Tumor flattened by pressure; ex- tensively adherent. 2 Merriman, Ibid., vol. iii • • D. D. 3 Ibid., vol. x I I R. R. R. D. D. Preceded by puncture. 4 I 5 6 Parks, Ibid., vol. ii •• I I D. Preceded by puncture. 7 I R. A. 8 ft tt it •• I R. A. Same patient as JNo. 7. 9 I A. 10 11 « « « « I I ... D. Ovarian origin somewhat doubt- 12 T3 Lever, Guy's Hosp. Rep., 1842.... Left side of pelv. I D. R. D. A. ful. I R. A. 15 tt tt ft tt Recto-vag.pouch. D. D. Cyst ruptured spontaneously. 16 tt tt tt it Left side of pelv. I R. A. J7 tt tt it it Recto-vag I R. A. 18 Ingleby, Facts and Cases in Obst. •• R. 19 I I I D. R. D. Embryotomy on account of child's death. 21 tt tt it tt I R. A. 22 Denman, vol. ii. p. 102 tt tt tt I D. D. 23 R. A. 24 Jackson, Lond. Med. Rep., vol. ii. I R. D. 25 26 Behrend Beclard, Bulletin Lond., No. •> I I R. D. A. D. Puncture followed by version. 27 Meissner, Diet, de Med. et Chir.... ? R. ? Cyst ruptured spontanously. 28 " ** 9 I ... D. b. Arm - presentation; spontaneous evolution. 29 Herbineaux, Sur les Accouch.Lab. Recto-vag.pouch. I ... R. 9 3° Baudelocque, Traits del'Accouch. I D. 31 Moreau, Nouveau J. de Med., 1820 Right side I R. A. 32 Steir (Puchelt) I I R. D. Perforation only on account ot child's death. 33 Davis, Op. Midwif... tt tt tt Recto-vag I ... R. A. 34 I D. D. 35 Huper, Grafe, and Jour. de Chir Right side I D. D. 36 Shuzer( Puchelt) Leftside I R. D. 37 J. G. Baker, Rev. Med., vol. vii... ? I D. A. Cases 35 to 40, inclusive, were 3« 39 La Chapelle Greenhalgh, Guy's H. Rep., vol. i. ? Posteriorly and I D. D. of malignant disease. laterally I ... D. D. Spontaneous premature labor. 40 11 tt tt Recto-vag. at- tached to bones. D. D. Csesarean section. 41 tt tt tt tt Recto-vag R. A. Premature labor induced. 42 tt tt tt tt I I R. A. " ' spontaneous. 43 La Chapelle D. D. 44 Perfect, vol. ii. p. 341 I R. I). 45 Lees, Clinical Midwif., Case 46.... " " « " 49.... I D. D. 46 I D. D. OVARIAN TUMOR COMPLICATING PREGNANCY. 5 Cases of Ovarian Tumor complicating Pregnancy Treated Expectantly.-Continued. 1 No. Reference. Position of Tu- mor in Pelvis. Left to Natural Powers. | Punctured. Embryotomy. | Pushed above Brim. | Turning. j Forceps. Rupture of Uterus. Results. Remarks. Mother. | Child. 47 48 Lees, Clinical Midwif., Case 48.... << cc <c << << Recto-vag 1 1 R. D. D. D. j- Nature of case doubtful. 49 Ward, Path Trans., vol. vi 9 . ... 1 D. D. 5° Mr. Wroman, Lane., vol. ii., 1849. Recto-vag 1 R. A. 5i Headland, Lancet, 1846 •• 1 D. A 52 Ramsbotham, Obst. Med., p. 216. 9 1 1 R. D. Perforation; after child's death tumor had disappeared. 53 Ashwell, Guy's Hosp. Rep., No. 2. 9 ? 9 Spontaneous rupture. 54 Langley, Lond. M. and S. Jour.... Right side R. A. << it 55 Playfair Recto-vag 1 D. D. 5<> Benny, Obst. Trans 9 1 R. A. Laceration of vagina; tumor 57 1 R. D. passed through and removed by Right side D. ligature. 58 Abdom. Tumors, Sp. Wells 1 D. Died four days after peritonitis from cyst-rupture; one child born during life of tumor. 59 • • D. D. Premature labor spontaneous at sixth month; week later, after great pain, cyst ruptured; death immediate. 60 << Two tumors D. D. Death from rupture of cyst; unde- livered. 61 62 1 " " ? 2 ... 2 R. 2D. Ovariotomy a few weeks after la- bor; one died, other recovered 63 Above 1 ... R. A. Subsequent successful ovariotomy. 65 66 J " " ? 4 ... 4r. 4 A. One tapped three times, one twice, two once. 68 Obs. Tr. Lond., vol. xi. p. 266 ? I R. A. Successful ovariotomy later. 69 Fischel Recto-vag 1 R. 9 70 Crawford, Med. Rec., 80, xviii. R. P- 473 9 I ? At a subsequent tapping pus was 71 Wiart, Arch, de Tocol., 82, ix. 428. Recto-vag I 1 R. ? found ; ovariotomy ; recovery. Dermoid right ovary ; subsequent enlargement, peritonitis, dis- charge of tumor and contents Warn, Obs. Tr., vol. xi., p. 198.... D. per rectum; recovery. 72 ? I ? Rupture of cyst. 73 Grigg, Br. Gy. J., 86-7, p. 264 << << it Ci Recto-vag 1 D. 9 Died following dav. 74 Left side ... 1 D. Multilocular, suppurating, ovarian cyst. 75 Recto-vag D. Braxton Hicks.-Six cases left to nature; all did well. Barnes saw death in one case from cyst-rupture at seventh month; in another peritonitis caused death. Rogers saw five cases : one tapped before delivery, mother and child lived; a second went to full term, mother and child did well; three premature labors, all mothers lived. Chadwick.-Three cases, non-interference ; all recovered. Battey.-Four cases, non-interference ; three died from cyst-rupture; one died from abortion. Sutton.-Two cases in which death followed abortion from twisted pedicles. Table of Cases in which Ovariotomy was Performed during Pregnancy. No. Reference. Operator. Months Preg- nant. Re- sult. Remarks. I Zeits. f. Geb. u. Gynak., 1880, p. 383. Schroeder. 7 R. Delivered at full term. 2 • • 4 •» Previously tapped ; aborted thirteenth day. 3 < t it 3 * ' Delivered at full term. 4 << 7 • • Premature delivery on fifth day. 5 • « 3 • • Delivery at full term. 6 •» • * 3 ' * Normal delivery at full term. 7 4 Aborted in seventh week, followed by septic infection. 6 OCA RIAN TUMOR COMPLICATING PREGNANCY. Table of Cases in which Ovariotomy was Performed during Pregnancy.-Continued. No. Reference. Operator. Months Preg- nant. Re- sult. Remarks. *8 Abdominal tumor. Spencer Wells. 4 R. Delivered of a living child at full term. 9 IO tt 3 3 t. tt tt it tt tt 4 ** " at sixth month. 12 • • »» 7 " next morning after operation. T3 <« Ci 5 D. Previous rupture of cyst; peritonitis and moribund when operation done; delivery nine hours later; death fifth day. 14 • • tt 4 R. Delivered at full term. IS • • 7 • • Child born twenty-five days later. " at full term. 16 tt (( 4 T7 tt 3 *• Abortion six days later. fi8 tt cc 4% *• Uterus opened by mistake ; contents removed. >9 Austral. Med. Gazette, Fortescue. 4 • • Accidental puncture of uterus ; Porro's operation. 1883-4, iii. p. 169. 20 Berl. K. Wochenschrift, W. Baum. 4% Aborted two days later. 1876, p. 172. 21 Am. Journ. Obstetrics, Munde. 5 *• Uninterrupted pregnancy. 1886, xix. p. 1272. 22 Ib., p. 525. Thornton. 3 Both ovaries removed ; delivered eighth month ; healthy child. 23 Canada Lancet, 1886-7, Gardner. 3 »• Delivered at full term ; living child. xix. p. 161. 24 Centralbl. f. Gynak., Barony. 6 " twenty-one days later. 1887, xi. p. 139. 25 Medical Record, 1882, Bennett. 3 •• Abortion ten days later. xxi. p. 22. 26 London Lancet, 1885, Stony. 3 Delivery at full term. 11. p. 985. 27 Am. Journ. Obstetrics, Pippi ngskoeld. ( ( " seven hours after. 1880, xiii. p. 304. 28 Trans. Am. Gyn. Soc., Wilson. 4 tt Continuation of pregnancy. 1880, v. Ixxxi. p. 100. 29 tt J. M. Sims. 4 tt Delivery at full term. 30 W. L. Atlee. 2 tt Died a month later from exhaustion. 31 • * ? • • Went to full term. 32 F. Bird. ? Abortion two days later. 33 • • Gabahin. 6 • • Delivered at full term. 34 L. Tait. 7 D. Labor sixth day after, and death in a few hours. 35 36 tt W. Baum. T. G. Thomas. 6 9 Miscarriage day following; peritonitis resulted. 37 (( J. G. Kimball. 3 tt Peritonitis. 3« Am. Journ. Obstetrics, • ' 3 »• »t 39 W. H. Byford. 7 R. Pregnancy unsuspected ; uterus punctured; contents re- 1879, xiii. p. 31. moved. 4° Austral. Med. Gazette, Thomas Hillas. 8 Uterus accidentally wounded; opened; contents re- February, 1875. moved ; living child. 4i Unpublished. Montgomery. 7% D. Premature labor seventh day, followed by septicaemia; Stratz Zeitschr. f. Geb. death thirteenth day. 42 Schroeder. 4 R. At full term ; convalescence normal; child living. u. Gynak., 1887. 43 3 twins; child living. 44 8 forceps delivery ; child living. « tt 3 3 tt child living. (I tt 6 (( 49 Unpublished private letter. E. Y. Beall (Texas). 3 Operation May 12,1887 ; course of gestation undisturbed. * Winckel (Parvin's edition) operated twice; both recovered ; no miscarriage. t Tait (Disease of the Ovaries, fourth edition, p. 293) reports ten additional cases ; all recovered.