INTRODUCTORY ESSAY ON THE HUMAN ORGANISM AND ITS FORCES. WITH REMARKS ON DR. LEHMANN'S DOCTRINE OF VITAL FORCES. BY SAMUEL JACKSON, M.D., PROFESSOR OF THE INSTITUTES OF MEDICINE IN THE UNIVERSITY OF PENNSYLVANIA. OF THE HUMAN ORGANISM. GENERAL RELATIONS. The organism of man, in its physiological, pathological, and therapeutical relations, is the subject and object of medical science. A comprehensive view of its general nature, and of its varied phenomena, will facilitate the investigations indispensable for a perfect understanding of them, by which alone medicine can be constituted a science. Without this knowledge, it cannot rank above an art or empiricism. Regarded in its completeness, it is an organic mechanism, the last and the most marvellous of the works of God; the fulfilment of the Creative thought in this world. In its structure, it is in the highest degree complicated ; in its nature, it is compound: it com- prehends within itself all organic nature. As in every mechanism, its phenomena are divisible into statical and dynamical. The first embraces its material structure and forms: the second, its varied movements and its forces, or causes of its actions. It includes three distinct natures, or spheres of existences-vegetable, animal, and spiritual, or psychological. They form three separate classes of phenomena, or branches of science; vegetability, animality, spirituality, or psychology. The first is characterized by growth, development, nutrition, and secretion: the second, by sensibility, general and special; contractility or irritability; spontaneous and voluntary movements and locomotion : the third, by consciousness, perception, ideality, causality, moral sentiments, and instincts. The actions belonging to the first, are vital, chemical, and physi- cal; to the second, mechanical, physical, and dynamical; to the last, psychological and metaphysical. 20 OF THE HUMAN ORGANISM. The special or organic instruments of the first are germs, cells-epithelial, nWcousA and glandular - fibres, and the gan- glionic or sympathetic nervous system: of the second, muscular fibres, muscles, and the spinal nervous Vystem, and nervous organs of the special senses; of the third, the qerebral lobes, hemispheres, or brain. , k » The above phenomena blend together, are interdependent, closely associated; and are the most intricate that exist in nature. They can be understood only when subjected to an accurate analysis, by which each component of a complex phenomenon may be sepa- rately demonstrated. This indispensable process for the acquiring a reliable knowledge of organic phenomena, necessitates a compe- tent acquaintance with each science of which the elementary phe- nomena are subjects. A deficiency of this requisite has been, and continues to be, a source of error in observation, and of fallacy in interpretation. Properly to comprehend a complex phenomenon, it must be recognized as such; it must be viewed in each of its aspects, in each of its separate attributes; the action and influence of each component part must be appreciated in the production of the gene- ral result, the object of research. A partial view, however complete it may be; the determination of a single property, or of a single component, however accurate, cannot explain the attributes, actions, or nature of the compound. Errors of this kind have abounded in medicine. It is only within a few years that the means of correctly analyzing the phenomena of living beings was possible. The unstableness of all former theories and doctrines in medicine arose from this defect. They were based on a partial view, or on a single fact of life, mostly dynamical, as vital force, and irritability, or sensorial power; or on chemical views. Most of the organic chemists of the present day neglect all other components of a phenomenon except the chemical; and the inferences are conse- quently incorrect, although the chemical fact they establish may be of great value when taken in conjunction with others. The chemi- cal view presented of the blood in most works of organic chemistry, gives no adequate idea of that fluid as circulating in the vessels, and of its relations to vital phenomena. The pure physiologists who discard chemistry and physics as the leading characteristics of organic or vegetative functions, are nearly as remote from the truth as are the chemists. A just appreciation of the complex phenomena OF THE HUMAN ORGANISM. 21 of the human organism can be obtained in no other mode than by viewing and treating them by the lights of the collateral, physical, chemical, and other sciences, to which their elementary phenomena belong. The material substance, the basis of the structure of the organism, is plastic, or organizable matter. The elementary plastic matter is albumen, which becomes transformed into various proximate plas- mata, of which the different s^X elementary tissues and organs are formed. CHEMICAL RELATIONS. Organic matter has for its constituents the common chemical elements of inorganic bodies. Four of these, carbon, nitrogen, hydrogen, and oxygen, may be regarded as the special chemical elements of organic matter. They alone, of all the chemical ele- ments, possess the power of forming almost unlimited series of com- binations with each other, and those series again are endowed with similar powers of combination. This attribute adapts them to the purposes of organic nature: without it, organic matter and organic bodies could have no exist- ence. The chemical elements that constitute organic matter, are not divested of their special nature, properties, or relations, when they enter into its composition: they do not cease to be chemical substances any more than when they form inorganic compounds. The older physiologists were firmly convinced that chemical actions and vitality were essentially incompatible; and many physicians of the present day adhere to the same opinion. From the imperfection of chemistry, the chemical actions of living beings could not be recognized or understood, and were denied. So far are these opinions from the truth, that vital actions and organization are impossible without chemical action. Organic matter is not, like inorganic, an originally created, self-existing, and indestructible substance, as it was supposed to be by Bufibn. The vegetable kingdom is the great chemical laboratory of nature, in which are effected the decompositions of carbonic acid, water, and ammonia, in order to obtain the four essential chemical elements of organic matter, and to combine them along with sulphur, phosphorus, &c., into an infinite number of organic matters, vegetable and animal. These are the materials for the organization and development of the 22 OF THE HUMAN ORGANISM. plants themselves, and animal organic substances, for the construc- tion of animals. The albuminoid organic substances, named by Liebig vegetable albumen, vegetable fibrin, and vegetable casein, are the primary or crude organic substances, elaborated by chemical action in vegetable cells, destined to the production of animal albu- men, fibrin, and casein, the crude organic plasmata, or substances from which are formed the immediate organizable or plasmatic matters of the different animal tissues. These last organic sub- stances are produced in The formative act of nutrition or assimila- tion, at the n^ment-the organic form;pl$he special animal structure •is generated. Thus, musculin, a chemical modification of albumen, does not exist in the blood. It is known only as forming the or- ganic material composing the solid portion of the muscular fibrillae: the transformation of the albumen must take place in the muscular fibrilla simultaneously with the production of its form. The or- "ganic matter of animal tissues is not permanent. From the great number of its chemical equivalents, or atoms, it is highly mutable. This character is most striking in some structures, as in mucous, glandular, muscular, and nervous tissues. The functional actions of organs cause waste and destruction of organic material propor- tioned to their activity. This is a result of chemical action, indis- solubly connected with vital action. In vegetables, the predominant chemical action consists in the deoxidation of organic substances, the oxygen being chiefly discharged into the atmosphere, while new organic substances are produced, as wax, oils, acids, &c., from the deoxidation of starch. Oxidation is the predominant chemical process in animals. The oxygen introduced into the blood by the function or act of respiration, combines with the carbon and hydrogen of the organic matters of the blood and the tissues. The whole chemical arrangement is broken up, and a reduction of the complex plastic substance into simpler bodies takes place, from successive processes of oxidation. They are creatin, creatinin, inosin, inosic acid, uric acid, urea, and, in addition, lactic, sulphuric, and phosphoric acids, and other unknown substances that lie con- cealed in the extractive matters enumerated by the chemists as existing in the blood and urine. Independent of these normal chemical actions, consisting in the molecular changes and transformations of the plastic organic matter, there are other chemical changes, some therapeutic, some abnormal or pathological, belonging to the relations of the plastic OF THE HUMAN ORGANISM. 23 or organizable substances with other bodies. Albumen, fibrin, and other proximate organic bodies, unite chemically with many of the chemical elements, as with additional quantities of oxygen, or with acids, metallic oxides, and earthy, alkaline, and metallic salts. Through this combination some of these substances are absorbed into the blood. Doubtless many other bodies possess chemical relations with the plastic organic substances of the blood and tissues, some entering into combination with them, others exciting molecular action and evolving new compounds, or transforming them into new matters, by causing new molecular arrangements and production of new organic matters. In this mode, abnormal contagious animal poisons are generated in the organism, when in- troduced into it by inoculation or otherwise. A minute quantity of smallpox matter inserted in the skin, or an invisible miasm of it inhaled from the atmosphere, acting as a kind of ferment, will give rise to the production of some ounces of an identical matter, in a case of confluent smallpox. The inoculation of a small quantity of putrid organic matter by a slight wound or scratch in dissection, will so destroy the crasis of the blood as to cause death. Absorption of sanious discharges from the uterus, it is probable, gives rise to some of the fatal forms of what is called puerperal fever. And again, the normal chemical changes attending the organic actions are accelerated by some bodies, as acetate and nitrate of potash, iodide of potassium, and the mercurial preparations. It is this that con- stitutes an alterative action. Those substances are organic altera- tives. Other substances retard those changes and diminish the waste of the tissues; such are alcoholic liquors, caffein, thein, and the narcotics. To a certain extent, it may be the action of some vegetable tonics. The whole history of organic matter, it is apparent, is essentially chemical. Itself a chemical product, it is incomprehensible in its infinite, endless forms, and incessant changes, without a knowledge of chemistry. It is the elaborated product of the chemical labora- tories of nature-vegetable organic cells. But the immediate plastic material of each tissue of an organized being, always a special organic material, is generated or assimilated from a crude plasma of the nutritive fluid, in the tissue itself, by the organizing or germ force of the tissue. The formation of organizable plastic matter, necessitates a living organism, independent of which it can have no existence. In this necessity, we have the scientific demonstration 24 OF THE HUMAN ORGANISM. of a creation, and the direct primary agency of a Creator, the first cause of the organized world. Organic chemistry is identified with physiology and medicine. No absolute progress can be made by either without it. The future progress of both those departments must depend, to a great extent, on the development of its principles and higher perfection of its methods of investigation. The present work, principally a translation of Lehmann's Handbook of Physiological Chemistry, is believed to be the best adapted to initiate the student in a know- ledge of physiological or organic chemistry, indispensable to a scientific medical education. STATICAL RELATIONS. The animal is an organism, a complicated living mechanism. In carrying on its numerous and diversified operations, it presents a great variety of phenomena, and possesses numerous subordinate instruments, each appropriated to a special office. They are termed organs and apparatuses of organs. Each organ and apparatus possesses a special organization, is endowed with a special vital activity and properties, performs a special function, and manifests special phenomena. To be thoroughly known, they must be sub- jected to exact analysis, be investigated by experiment, as are inorganic bodies, and be assigned to the natural class to which their actions and phenomena show them to belong. A chemical, physical, mechanical or dynamic fact does not lose its proper nature and attributes, or cease to be subject to its proper laws, because it occurs in a living organism, and is associated with special vital facts or phenomena, or controlled and directed by vital force. In the living organism of man are found to concentre all the actions and phenomena, chemical, physical, and mechanical, that exist in the exterior inorganic world, combined with those peculiar to organized or living beings. This may be expressed in the formula: inorganic phenomena, plus organic and psychical phenomena. The chemistry, physics, and mechanics of the human organism are transcendental; they are each the development of the highest possible conception in each branch of knowledge; the instruments that execute them are inimitable by any of man's invention, for the purpose of exemplifying the phenomena and principles of the natural sciences. Such, for example, is the eye as an optical instru- OF THE HUMAN ORGANISM. 25 ment, the ear as an acoustic instrument, the larynx as a phonetic and musical instrument, the vascular system as a hydrostatic appa- ratus, and the muscular system as a mechanical mechanism. The organism of man in action is a locomotive engine, in the perfection of its machinery and adaptation to its purposes, infinitely beyond any similar engine that man ever can devise. It is com- posed of a number of distinct mechanisms, or machines and instru- ments, by which it is self-formative; by which it procures and prepares the materials for its repair and renovation, conveys them to every part of its structure where they are required, generates its own temperature and the forces that work its machinery, and brings its mechanical powers into action. The intelligence for whose use this engine exists, whose will it obeys, whose work it performs, that rules and controls it for the purpose of accomplishing the objects of life, resides in and is a com- ponent part of the machine itself. The intellect is to the human locomotive, what the engineer is to the steam locomotive. It em- ploys the extraordinary powers of this wonderful and magnificent mechanism to mould exterior material nature, after the ideal crea- tions of its own interior and spiritual nature, evolved in ideas and thought. The state of society of any country, its institutions, its works, its science, its arts, the meliorating features impressed on the rude face of nature by its industry and labors, are the reflec- tion and manifestation of the intelligence, knowledge, and moral character of its people. By his locomotive machinery, aided by his inventions, that ren- der it more efficient, that augment his powers, man overcomes all the barriers and obstacles of nature. No mountain is so lofty as to be inaccessible to his footsteps, no valley into whose depths he cannot penetrate; he mounts into the upper regions of the air to gratify his curiosity; he perforates the earth and descends into its bowels thousands of feet below its surface, to bring forth its buried treasures; the wide expanse of ocean he has made his highway; and he circumnavigates the earth in the pursuit of pleasure, science, or wealth. These extraordinary powers he owes to his inventive faculties and the knowledge acquired by his intelligence. With their aid he devises the required means that enable him to seize on the forces and appliances of nature, to turn them to his purposes, and, through their agency, to triumph over nature herself. The amount of mechanical force and power, produced, and 26 OF THE HUMAN ORGANISM. expended in the daily working of the animal machinery, is far beyond what can be conceived by those who have not investigated this subject. I will here merely state that, for the organic functions of respiration and circulation, the daily amount expended is not less than some thousands of pounds; and a considerable sum is required for the daily operations of the ingestion and digestion of food and expulsion of the excretions; while the aggregate result during labor and locomotion of various kinds, is often enormous, exceeding frequently, two millions of pounds a day. The immediate mechanic force by which the mechanic power of the muscular system is brought into action, is generated in the spinal system, the anterior nervous ganglia of the spinal cord or axis, and appears to be either derived from a transmutation of heat into the nervous motor or excitor force; or that force and heat are correlative. A direct relation certainly exists between the two. MM. Jules, Serres, and other physicists, have demonstrated the identity of heat and me- chanic force: they are mutually correlative and equivalent to each other. This fact is expressed by M. Jules in the following for- mula :- One degree of heat is equivalent to 750 pound-feet. Or, One degree of heat is the equivalent of a mechanic force that will raise 750 pounds one foot. The same principle is equally true and applicable to animal me- chanics. In the animal mechanism, the heat, the equivalent of its mechanic nervous force, is evolved by the oxidation or slow combustion, chiefly of carbon and hydrogen, in the blood. The oxygen is introduced into the blood by the process of respiration, and the hydro-carbons and carbo-hydrates, by the food-as oils, sugar, starch, &c., digested and prepared by the functions of the alimentary canal, so as to be absorbed, and introduced into the circulatory apparatus. The amount of pure carbon that must be introduced into the blood, by the food, and oxidized, to furnish the heat cor- relative of the nervous mechanic force each day, in labor, is not less than from 10 to 12 ounces. In this exhibition of facts is de- monstrated the close, immediate connection between different func- tions and actions, as respiration, digestion, absorption, circulation, oxidation, animal heat, nervous force, and mechanical actions. The working power of man is a product of the food on his dish; it comes OF THE HUMAN ORGANISM. 27 from his meals: and so also is it with his blood, and flesh, his limbs, organs, and viscera. They are constructed of the nitrogen- ized organic matters of food digested in the stomach, absorbed and assimilated. Food or aliment is the commencement of organization; it may be said, of life; for the first vital action of the germ is to absorb and assimilate nutritive matter, for the augmentation of germ material, and the formation of the germ mass, the first stage in the develop- ment of the organism; and the whole of organic or nutritive life is the repetition of its first commencing act. FORCES, OR DYNAMICAL RELATIONS. This word dynamics is derived from the Greek power, force, rule. It was confined for a long period to the science of mechanics, to designate the laws and actions of mechanical machines and movements of bodies. It has acquired, with the progress of science, a much more extended application. It is now the equivalent or synonym of forces, and is employed to express the science of acting and moving causes, not only of solids or mechanical bodies, but of all actions and move- ments whose cause is unknown. In this sense it is introduced into medicine; and in physiology, is applied to designate the forces of the living organism, or causes of its actions; and in therapeutics, is used by some to express the causes of medical action as dis- tinct from the medical substance itself. In the mechanics of the muscular system, the term is of as legitimate application as in common mechanics. The spinal nervous apparatus is a dynamical system, generating forces that excite and control muscular actions, that perform the mechanical functions of the economy. The direct meaning of the word force, synonymous with dyna- mics, derived from the Latin fortis, is strength, power, energy. It is used for want of a more fitting word in science to express an abstract idea, a result of a mental process of reasoning. The common experience of our senses teaches us that inorganic bodies, at rest, never move unless set in motion by an impulse derived from some other body, agent, or matter. It does not move of itself. Whatever produces the motion, is regarded as the cause of the motion, and the mind infers it exerts an action indicating a force as the cause of the motion or action. 28 OF THE HUMAN ORGANISM. But movements and actions are observed to occur often without any known tangible or perceptible cause of the movement or ac- tion. Of this unknown cause of action and movements, the mind forms an abstract idea by a process of reasoning, as a force or unknown cause, producing actions, movements, or, in other words, phenomena. Phenomena, actions or movements, of the same na- tures and characters, are constantly reproduced under the same conditions. The mind infers from this circumstance the existence of constant, persistent, and special forces. The term force has no other meaning-expresses no more than an unknown cause for known or observable phenomena. Phenomena, recognizable by our senses, and comprehensible by the intellectual faculties, are numerous, various, and different. From their resemblances, coincidences, and differences, always permanent and consistent, they are capable of being arranged into divisions, classes, orders, genera, &c.: that is, the mind arranges and classifies phenomena according to the above circumstances of agreements and dissimilarities which are observed to exist in nature. The forces to whose action the special phenomena observed in nature are to be attributed, are divisible into two classes: the physical or general, and the organic or vital forces. The first are classed and named by physicists, as gravity, light, electricity, mag- netism, and chemical affinity. These terms in reality express no more than constant modes of actions, or phenomena: characterized by Mr. Grove as " affections of matter." They are the only forces recognized by physicists. To- which, it appears to me, are to be added the second class, or vital forces. They are, 1st, organic, or formative force ; 2d, the spinal nervous excitor, and motor forces ; and 3d, muscular contractility, or irritability. Before proceeding further in this discussion, it will be necessary to make a short digression for the better understanding of this subject. It is a remarkable feature of intellectual operations, that from the earliest period of knowledge, of science, and philosophy, down to our day, two distinct modes of viewing this subject, two oppo- sides of this question have occupied, and been presented by, -i-ffimking and observing minds. The ideas arising from these views have lain, and yet lie, at the root of scientific principles and philosophic thought, forming two antagonist schools. They generally date from two of the eminent intellects of Grecian OF THE HUMAN ORGANISM. 29 origin, Pythagoras, born 584 B. C., and Thales, 640 B. C. The first taught that matter was incapable of any action or movements from its innate powers. God was the power whence all natural phenomena proceeded through subordinate agents. This is the origin of the spiritual philosophy and the modern dynamic theories. The abuses and perversions of this doctrine by the ignorant, and those incapable of enlightened and broad intellectual views, have produced ontology in science, and superstition in religion. Thales, on the other side, regarded matter as possessed of inherent or innate forces and properties, from which all natural phenomena, and all objects, animate and inanimate, have proceeded, and con- tinue to be produced. This is the material school, and, pushed to its extreme results, leads to atheism. In our time, the first of these primary conflicting opinions is represented by the doctrine that matter is devoid of active forces, and that phenomena are dependent on imponderable forces acting on ponderable matter, changing, modifying its states, conditions, and forces; and are the sole causes of action or phenomena. The second is embodied in the doctrine that matter is endowed with active forces as properties, by and through which, all the phe- nomena of nature, its forms, actions, motions, molecular or in masses, are accomplished. This doctrine escapes from the inevitable con- clusion to which it leads-atheism-in attributing, as is done by some, the possession of these properties by matter, as endowments conferred on it by the Supreme Creator. Modern researches have shown that the forces of nature, pre- viously enumerated, are correlative, cannot exist independent of, and are convertible into, each other. The conclusion from the above facts and views, is that what are termed natural or physical forces, are no more than modes of mani- festation of one force, one agent. In 1836-7, I advanced this opinion, and, in addition, that the phenomena of living beings were to so great an extent identical with the ordinary phenomena of physics, that " Physiology might very properly be designated as organic physics." In 1843, Mayer, of Ileilbron, promulgated the same opinion. But it was Mr. Grove, of London, who first, in a complete treatise, undertook to prove the truth of this proposition. In a 2d edition, 1850, he throws out the conjecture that the doctrine of correlation will apply in physiology; and cites muscular action and animal heat as probable instances. This very application of the 30 OF THE HUMAN ORGANISM. doctrine I had made the year previous, 1849, to animal mechanic force as correlative of heat, in a paper read at the meeting of the American Medical Association, held in Boston. This doctrine was announced by me as early as 1837, in a pub- lished lecture. This proposition was then laid down, " that the same causes and actions which in inorganic bodies constitute physics, in organic bodies constitute physiology, or, as it may be more aptly termed, organic physics." The idea then broached, subsequently ripened into a complete development; and my lectures were arranged on a plan in con- formity to it. Dr. Carpenter, in the preface to the third edition of his General and Comparative Physiology, claims " as more particularly his own," the doctrine of the " mutual connection of the vital forces and their relation to the physical." I indulge the hope that this statement of similar views promulgated by myself eighteen years since, annually repeated and so extended as to form a full section of my course, will not be considered out of place on this occasion, or subject me to the imputation of egotism. The doctrine of the correlation of the physical forces has been generally adopted; and consequently, if a clear insight has been obtained of the nature of any one or more of them, that of all the others must be similar or identical. AV hatever theory is adopted to explain the phenomena of one must be applicable to the others. Now, as respects two of the forces, light and heat, physicists have, without an exception at this time, embraced the dynamical or undulation hypothesis. According to this doctrine, the phenomena of light and heat are due to motion or undulatory vibrations excited in an aerial fluid existing throughout the universe, occupying the interplanetary spaces, and penetrating and existing in the interstices, and surrounding the molecules of the densest bodies, whether inorganic or organic. This fluid is named the Ether. It is mentioned by Aristotle; Newton advocated the hypothesis, and employed it in solving some of his philosophical problems; he estimated its specific gravity as 750 times less than the difference between the atmosphere and granite rock. Euler assumed that the ether is 36,000,000 times thinner, and 1,278 times more elastic than atmospheric air. The grounds of this hypothesis are by no means vague. It is clear, without any doubt, that in vision or seeing there must exist OF THE HUMAN ORGANISM. 31 some agent or body between the retina of the eye, the nervous sensitive tissue or membrane, and the exterior visual object. The retinal membrane is the portion of the eye that receives the direct impressions proceeding from the external body. In this* impres- sion, in reality, consist light and color. It is not a single and simple membrane, but a complex one; it is composed of thousands of minute, independent and distinct sensitive spaces, or, as they may be regarded, associated retinas. Each one of these receives a separate, distinct impression, coming from each separate distinct point of the exterior body seen, a perfect miniature mosaic picture of which is thus represented on the retina, or is, it may be said, pricked into it by the rays of light; or, more properly, the undulations of the molecules of the ether. This body, this agent intermediate between external bodies and the retina, exists in the interior of the eye, diffused through all its tissues and interior media. It is the sole normal or physiological excitor of the special nervous sensibility of the retina, and the nervous central optical organs, provided in the order of nature, that animals may possess the function of vision. This is effected by the immediate relation this agent possesses with the nervous sensibility of the retina of the optic nerve and the optic lobes. The two must be closely related, and analogous or identical in their nature or innate constitutions. This accumulation of scientific probabilities almost amounts to a demonstration that a body or most tenuous fluid is present between all external bodies and the retina in the eye of animals. It is not the atmosphere, for it cannot penetrate the cornea, the lens, or the humors of the eye. Its presence would be injurious to vision by disturbing the course of the rays of light. Vision is not limited to the surface of our globe; it extends to the infinitely remote regions of space, and consequently the ether, whose systems of undulations or waves traverse those immeasurable dis- tances, and, impinging on the retina, cause light, or vision, must fill all space. The present philosophical hypothesis of physical or natural forces, presented in the preceding summary, in the present state of our knowledge must be accepted as the truest exposition of the causes of natural phenomena. Having it before us, we are better prepared to examine the relation in which they stand to the forces 32 OF THE HUMAN ORGANISM. that, in the living organism of man, are the causes of its special actions and phenomena. These forces are manifested in the organic actions of which they are the causes, and must be studied and interpreted through them. In this manner alone can their identity or diversity, their correla- tion or irrelevancy with the physical forces be correctly appreciated and determined. ORGANIC FORCES. The only forces and phenomena that can properly be named organic or vital, are such as are exclusively found in organized and living beings. Two series of phenomena alone possess this charac- ter. They are, for the first series, the production of a formless plastic matter, and the development of typical organic forms-tis- sues, organs, organisms-from this formless material, and their maintenance by growth and nutrition. For the second series, they are the nervous excito-motor forces, and muscular contractility. Sensibility and intelligence, or the psychological actions, are nervous phenomena, to which the term force, and the actions oi force, are not applicable. The first series is common to all organic, or living beings-vege- table and animal: the last exists exclusively in animals. As the causes of the .above pheno ntena present special characters that distinguish them as mu^h from the physical forces as they are themselves distinguished from each other, I can perceive no valid reason why they should not be placed in a separate class, named organic forces, as they are most clearly the antecedents, or causes of especial organic phenomena, or actions. Guided by the light of our present philosophy, the organic or vital forces are regarded by many physiologists, among them Dr. Lehmann, the author of this work, as correlative of the common forces of the inorganic world. I now proceed to an investigation of the phenomena character- istic and distinctive from all others, that are specially organic, that are exclusive to living beings and to animal life. The first is- - ORGANIC, FORMATIVE, OR VITAL FORCE. This force presides over all organic beings-vegetable and animal. No organic form or action, or any phenomena of life, can have OF THE HUMAN ORGANISM. 33 existence in its absence. It is as perfect in the lowest and simplest as in the most complex and elevated of organic beings; in the monad as in man; in the cell vegetable as the oak; in the lowest form of tissues as in the most complex and developed. Organic force is the first cause of organic forms. Modality, or the production of organic forms from a formless, plastic fluid, or organic matter, is its distinctive characteristic. It is embodied in the germ. No living, no organic form, endowed with vital activity, ever had existence, or can exist, independent of germs. Every organic form is the realization, in an appropriate and special or- ganic material, of an Neal model, or type, of that form. This force is not self-acting. It is dormant like electricity, caloric, light, until excited into action. A definite temperature is an indis- pensable condition. In warm-blooded animals, 100° F. to 102° F. in the blood, is the normal temperature. Below this, say 96° to 97° F., germ development is imperfect, and arrested in its first stage. ORGANIC, OR VITAL ACTION. The result of the activity of organic force, excited by caloric, or heat, is the production of an organic action, life or formative action, summed up in the term nutrition. The nature and constituent factors of this action are now to be analyzed. It is a compound action, composed, 1st, of the production of an immediate, or special plastic organic matter, from a crude or proto- plasm ; 2d, of the creation, or production of special organic forms from the organic plastic matter ; 3d, of the death, or chemical dis- integration of the organized substance of the interior structures, and its transformation into simpler and lower combinations, form- ing the matters and substances of the excretions ; 4th, the moulting, desquamation, or casting off the dead and recremental material of the organic structure of the internal and external surfaces, in com- munication with the exterior world. At the same time, new or- ganic forms, and organized structure are being produced. The organic plastic matter is special for each tissue-musculin is the material for ^.uscular tissues, neurin for nerve tissue, the vari- ous gelatiniform^materials for areolar, serous, fibrous tissues, &c. Organic forms are equally various. Each tissue and each organ has its speciality of form, and arrangement of its component parts. These component parts, each having a special plasm and a distinct organization, are interwoven with the utmost intricacy, necessitating 34 OF THE HUMAN ORGANISM. different and complicated chemical and constructive processes simul- taneously occurring in the same place and same moment of time, which are utterly inexplicable and impossible as the operations of the physical forces. The organic form produced is maintained amidst the incessapt decomposition of the organic substance in which the type of form is expressed. This is the most significant and characteristic fact of the organic or life action. It individualizes and separates it from every other kind of action. All inorganic forms are maintained by the absolute repose, or equilibrium of molecular actions. The form is destroyed utterly, when molecular actions are excited. Incessant molecular activity, and persistence of form, are the essentialities of organic, or life action. The cessation of the special molecular activity of living structure, is productive of the cessation of organic, or life action: it is death. The organic force disap- pears ; chemical affinity, that was forced by it to effect special com- binations of chemical elements, to form special plasmata, is now set free, to exert its natural tendencies, and the result is putrefac- tion, if the temperature be such as to excite it into a certain degree of activity. An organic action analyzed, reduced to its component phenomena, presents evidences of the combination of the following series of actions and phenomena:- 1. Organic, or formative force, producing, creating it may be said, organic forms, or manifesting modality, stamping the form after an ideal type of tissue, or organ. 2. Chemical affinity, chained, con- trolled, and forced into the formation of special chemical combina- tions and formation of plasmata. 3. Chemical disintegration, retro- grade chemical products to be eliminated, or the dead organic material desquamated, and thrown off from exterior surfaces. This scries and union of forces and actions, entering into an or- ganic, or life action, can occur and exist only under absolute special conditions. These are, 1st, the presence of organic force embodied in a germ; 2d, a crude organic plasm; albumen in animals of the higher classes, capable of transformation into special plasmata; 3d, a definite temperature of 100° to 102° F.; 4th, oxygen, to effect, by its direct action, the chemical decompositions of the organized mate- rials wasted in the organic actions, and indirectly accomplishing the same result by the thousand acts of oxidation occurring in the organism, generating its temperature, and maintaining the endless OF THE HUMAN ORGANISM. 35 chemical actions required for the production of the secretions, ex- cretions, and numerous other products of the economy. The preservation of the above conditions of organic, or life actions, is the object of dietetics and regimen, or art of preserving health; and the investigation, of those conditions, in all their varied rela- tions, constitutes the science of hygiene. Their restoration, when in an imperfect state, or in any mode disordered so as to con- stitute disease, is the object of therapeutics and the practice of medicine. NERVOUS, OR MECHANIC FORCE. This force is wholly dissimilar, in every respect, to organic force. The character and object of this force, is to work the machinery of the organism so as to bring into operation the mechanical power of the organism required for various objects indispensable to its existence, to maintain the conditions of the organic actions, and for the pur- poses of animal existence in the creation. Its most perfect mani- festations are in animals of the higher classes. This nerve force is generated in the spinal cord, or axis, and the cerebral axis, medulla oblongata, crura cerebri, thalami, and corpora striata. These organs constitute the dynamic, or force generating apparatus. Mechanic nerve force is to the animal organism what steam is to the locomotive. The dynamic apparatus, or cerebro- spinal axis, is in the organism what the boiler is in the steam engine. This statement exhibits, in strong relief, the difference between organic and nervous force. The first exhibits no mechanic power in the organism, produces no direct mechanic effect. It is limited to the molecular actions required for the production of plastic matter and organic forms. The spinal nerve force is exclusively manifested in the mechanical movements of masses, as of the circulation of the blood, the expan- sion of the chest in respiration, in movements of the limbs and body in locomotion, and in the production of other mechanical effects. Notwithstanding these wide and strongly marked differences between them, the two have been, and continue to be, confounded together as one-as identical. This error, regarding nerve force as an Organizing force, as the cause of all organic phenomena, was committed by Oken, by Carus, by Klencke, by Unger, by Lamarck, Legallois, and Dutrochet, and is yet entertained by many French 36 OF THE HUMAN ORGANISM. and German physiologists. It is advocated by a distinguished teacher in this city, who bases many of his pathological views on this hypothesis. This error arises from not analyzing the complex phenomenon of an organic action, and of not studying it in its first inception in the formation of germ matter, and development of the multiplication of the germ into the embryonic germ mass, the first stage of the animal organization; and further, the ignoring of the process of development in the seeds of plants, and of their organ- ization. To find the truth, it is not to be sought in complicated phenomena, but in the simplest, in which its expression is clear and distinct. Nerve force has been shown to be limited to an apparatus. Actions or phenomena requiring an organ or apparatus are, and must be, functional. Nerve force is, consequently, a function or office of the organs and apparatus on which it depends-the spinal dynamic apparatus. The apparatus itself is constructed by the formative organic actions directed and maintained by organic or vital force. Spinal nerve force is restricted to two series of phenomena-ex- citation of muscular mechanical actions and of general sensibility. Organic or vital force is universal in the organism; it requires no apparatus. It is present in every act of life, in every tissue, in the simplest as in the most complex: it is active in every living organic molecule. Spinal nerve force is composed of two distinct forces-an excitor force and a motor force. Each has a separate nervous apparatus or combination of organs for its manifestation. Excitor Nerve Force. The first, or excitor force, has a close affinity with sensibility; they are constantly confounded. It is an excitor of general sensibility, as well as of motor force. It is somewhat difficult to distinguish between them. Sensibility may, possibly, be no more than the mental perception and consciousness of the excited state of the excitor force, or of the afferent nerves. The excitor force, like special sensibility, is in contact with the exterior world. Impres- sions on the skin or mucous membranes excite it into action, as cold air, or water sprinkled on the face, recalling respiration in fainting, and worms or indigestible food in the alimentary canal, causing convulsions or spasms. OF THE HUMAN ORGANISM. 37 Certain irritations and impressions also of which we have no consciousness, excite its action normally, as in respiration, main- tained by the unconscious presence of carbonic acid or black blood in the lungs, and abnormally by splinters lodged in fascias, causing no sensation, yet producing tetanus after the wound has healed. It is independent of the brain or cerebrum. This is shown in complete palsy of sensation and motion, caused by injuries to the spine. The lower extremities will be drawn up violently, from tickling the soles of the feet, though the patient is unconscious either of the sensation or the movement of the limb. The apparatus of the excitor force are the posterior ganglia of the spinal marrow or axis, of the medulla oblongata, and nerves commu- nicating between those nerve centres and exterior and interior sur- faces. These nerves have ganglia on their roots, which is a distin- guishing character, though their office yet remains unknown. All impressions on, or states or conditions of surfaces are transmitted to the excitor ganglia or the posterior nerve centres of the spinal cord and medulla oblongata. Motor Force. The second or especial relation of motor force is with muscular contractility, and its function is to excite muscular contractions from which result mechanical effects. The apparatus to which it belongs, and through which it acts, are the anterior ganglia or nerve centres of the spinal marrow or axis and medulla oblongata, and the nerves that place them in connection with the muscular system. These nerves have no ganglia at their roots. This force is the direct physiological excitor of muscular contractility; and, in the normal state, is the only proximate cause of muscular action. Excitor and motor force are, in the organism, constantly asso- ciated in action. The continuous play of the respiratory muscles, of the heart, of the muscular coats of the stomach and intestines, is maintained in this manner. They are involuntary machine or automatic actions. The two forces are not identical, and often act independent of each other. Irritation, or any excited state of excitor nerves and surfaces, will cause pain without producing muscular actions or influencing motor force, as in some pure neuralgias. Sen- sations and muscular actions sometimes occur simultaneously, are 38 OF THE HUMAN ORGANISM. connected, but more frequently sensations are unattended with muscular actions. The nervous force exhibits in some of the inferior animals remarkable varieties of susceptibility to the impressions of external bodies. The Batrachians, when placed in water of the temperature of 100° to 110° F., are immediately thrown into a state of spasmodic rigidity; a tetanic state is developed, which in a short time would prove fatal. If in this state they are thrown into water of the ordinary temperature of spring water, 45° to 48° F., the spasm immediately ceases, and they resume their usual activity. In the Ophiura, or Luidia, a species of the starfish, the very reverse of what occurs in the frog is observed. If taken from sea water, and plunged into fresh water of the same temperature, they die instantly in a state of the strongest tetanic extension and rigidity. Motor force, associated with and excited by excitor force, pro- duces what are called reflex actions. This name, though generally employed, is objectionable, as it involves a hypothesis which has not been verified. Excito-motor actions and automatic actions are preferable, as they indicate positive phenomena. Motor force is also excited into action by other causes, the whole forming four classes of actions. The first is the excito-motor or automatic actions as above de- scribed, constituting involuntary actions. The second are the excitements of the motor force by the emo- tions, constituting emotional actions. The third are the excitements of the motor force by acts of the mind, attended with a consciousness of the mental action, and are called voluntary actions. By these actions is carried out some determination, or is accomplished some desire or purpose, or is fulfilled some idea. The fourth is a new class, unknown to metaphysicians, but recognized by physiologists. Motor muscular force is often ex- cited by a fixed, strongly impressed and vivid idea, without that active participation of the consciousness that is called volition. Hence the individual is unaware of the cause of the muscular action, and in some instances is unconscious of its occurrence. The nervous excito-motor or mechanic force is not constant; it varies incessantly. The apparatus generating it is exhausted by prolonged muscular exertions. This state is expressed by a sense of weariness, lassitude, or fatigue, according to the degree of ex- OF THE HUMAN ORGANISM. 39 haustion induced. It is renovated by repose, from which proceed feelings of vigor and activity. The following are the conditions indispensable to its generation and normal action :- 1. Gray neurine vesicles grouped into centres or species of ganglia in the posterior and anterior cornua of the spinal axis and in the medulla oblongata. 2. Nerves communicating between interior and exterior surfaces and the posterior ganglia of the spinal axis-afferent or excitor nerves; and nerves communicating between the anterior ganglia of the spinal axis and muscles-efferent or motor nerves. 3. Red blood corpuscles, in the proportion of 130 to 140 to 1000 of dry blood, or 510 to 520 of liquid blood. 4. A temperature of 100° F. in the blood. The identity of electricity and nervous force is a favorite suppo- sition with many writers at this time. The facts relied on are far from being positive. Those of Matteucci and Du Bois Raymond possess the largest amount of probability, but are not absolutely demonstrative. Molecular action is always attended with electrical phenomena. This kind of action is a constant characteristic of vital activity: and in those tissues and organs in which molecular action is ener- getic, electric phenomena are the most clearly manifested. Every living organism, as a whole, and in its several structures, is an electro-genetic apparatus. During life, the muscles, and the mucous membranes and skin, exhibit, with the galvanoscope, the most marked and highest evi- dences of free electricity. The nervous structure fails to affect this instrument in a decided manner, though the more delicate sensitive- ness of " the prepared frog's leg" proves its existence. This fact tends rather to show a less degree of electrical development in nerve structure, corresponding with slower molecular changes of organic substance, than in muscles and mucous membranes. Du Bois Raymond has demonstrated, by the peculiar apparatus he has constructed, and by his manipulations, that dead nerve struc- ture exhibits a feeble electric current. This can scarcely be con- strued as an evidence that the nerve force of the living apparatus is electricity. There is also a source of fallacy in the experiment that has not been noticed. Spallanzani had observed the fact that organized structure, when dead, until putrefaction has commenced, 40 OF THE HUMAN ORGANISM. continues to exhibit the constant phenomena of living structures, the absorption of oxygen and elimination of carbonic acid. Robin and Verdeil assert that they have verified the correctness of this obser- vation. This chemical action must of course generate electric currents. Although the proofs of the identity of nervous force and elec- tricity remain as yet inconclusive, there is every reason to regard as probable a correlation between them; and that nervous force belongs to the same class; that it is, in fact, a special modification of the physical forces manifested in living organisms, and adapted to the special class of mechanical actions in them. It is ether transformed into nerve force, or this last is itself a modification of ether. REMARKS ON DR. LEHMANN'S DOCTRINE OF VITAL FORCES. BY S. JACKSON, M. D., PROFESSOR OF THE INSTITUTES OF MEDICINE IN THE UNIVERSITY OF PENNSYLVANIA. The foregoing views respecting the forces of the organism are at variance with the doctrine of the author of this work, Dr. Leh- mann. They are the opinions I formed early in my professional studies, and have been since entertained by me. The conviction of their general truth has strengthened with time and increased knowledge. The facts and arguments of Dr. Lehmann have been carefully considered and weighed, but have failed to convince me of their correctness, or to weaken confidence in my previous con- clusions. It is a fault not unfrequent with those absorbed in the pursuit of the positive sciences, and accustomed to find the objects of their researches subject to the application of fixed laws, and their diffi- culties solved by experimental demonstration, to expect that simi- lar means and processes are available and applicable to all other sciences. Habituated to reach certain results in the investigations of their limited range of phenomena, they demand the same con- ditions in those infinitely more complicated and widely different. The confidence with which they are inspired, leads them to assume that man's intellect is the measure of the universe, and that no truth can have a depth outreaching its capacity, or is placed beyond the grasp of its logic and comprehension. The unknowable is not acknowledged, and any hypothesis is preferred to a concession of a mystery. 42 REMARKS ON Yet, a moment's reflection must show, that the causes of the laws whose unerring certainty they boast, are unknown, are mysteries, and must forever remain as such. It is the error of Dr. Lehmann, and it is common to most physicists, more particularly chemists, that he views the complex phenomena of life in one aspect-in their chemical relations. The physiological, or especial organic phenomena, are entirely neglected or overruled, though the settle- ment of the question in discussion must depend almost exclusively on a thorough investigation, not of the mere organic substance and its nature, but of the sole material fact to be determined-the proximate cause, or origin of specialized individual organic forms- of the different organs and organisms of living beings. The principal arguments of Dr. Lehmann are battlings with shadows. The former physiologists were generally ignorant *of chemistry, and could not recognize chemical facts in the living organism. They were denied, and the matter of the animal eco- nomy was believed to be exempt from the laws of chemical affinity. All its actions were imputed to vital forces, exclusively existing in the organism. These opinions are attacked and refuted, though no longer advocated by modern physiologists. The identity of the chemical actions of living beings and of in- organic bodies is now generally admitted. It is granted " that the same chemical laws preside over the constitution and transforma- tions of different compounds, whether organic or inorganic." Ad- mitting the accuracy of this proposition, it does not authorize the assertion, that "all the differences observed between these two different classes of bodies are accidental, relative, and have nothing essential." Will it be affirmed that when an unfecundated egg is placed in the conditions for incubation, and the result is its putre- faction, while, in a fecundated egg, the albuminoid contents are transformed into blood, muscles, viscera, nerves, brain, heart, ves- sels, and organs of sense, and it is endowed with special sensibilities, with consciousness and voluntary movements, that these two classes of phenomena are only accidental, relative, and non-essential? It is certainly true, that chemical affinities and molecular actions are indispensable to produce the varied special proximate organic materials of the fluids, tissues, organs, and the living organism of the chick. But, without the presence of the germ, a fact neglected by Dr. Lehmann, this extraordinary play of specific chemical affini- ties, and specialities of chemical actions, and the development of some dr. lehmann's doctrine of vital forces. 43 hundred organic forms, included in the living being, from the form- less organic matter, could not have occurred. Certainly, here are displayed, in the two classes of bodies-inorganic and organic- differences that are not accidental, or relative, and that are essential. The same general facts are observed in the germination of seeds. If the germ cell at the hilum of a seed be artificially ruptured, and it be placed in the same circumstances of germination with a per- fect seed, the first will rot, while, in the other, are formed dextrin, grape sugar, cellulose, and albuminoid compounds; and these or- ganic matters are developed into the tissues and organs of a perfect plant. In these, which are but single series of organic phenomena, the most absolutely marked and undeniable differences are to be ob- served between the two classes of bodies: it is impossible to regard them as "accidental, relative, and non-essential." These phenomena have occurred in living beings with absolute constancy, in all generations of animals and vegetables, and are so completely under the control of positive law, that any one, or all of them, can be predicated and foretold with as much certainty as any chemical or physical action. Another argument urged as conclusive is the following: "We should not lay down a new force, a general specific cause, until we have eliminated all other possibly operative forces from the group of phenomena in question. A proof of the existence of a purely vital force is hence only to be obtained by an exclusion of every physical force.'' A full assent is given to the conditions of the argument; and it is affirmed most positively that the only phe- nomena-the exclusive attributes of a vital or organic force-the creation from a liquid formless plasm of typical organic forms, and organic instruments to execute physical, chemical, mechanical, and dynamical actions, in the living organism, which are operative only during life, cannot be explained by any one, or all of the physical forces combined. They ar.e absolutely excluded. Let the subject be expressed in special terms, and it is affirmed that neither heat, nor light, nor electricity, nor magnetism, nor gravity, can construct an eye, can form a retina, heterogeneous in its organic materials) complicated in the distinct organized anatomical elements of its structure, and endowed with a special sensibility-light and colors- manifested normally only when excited by a special external agent, 44 REMARKS ON the luminiferous ether. Nor can they generate the black pigment cells of the choroid coat, for the express purpose of suppressing the luminous rays, which have accomplished their impression, with- out which there can be no distinct vision; nor cause the formation anterior to the retina of the vitreous humor and the crystalline lens, admirably adapted in form, shape, and density, to refract the rays of light into a focus, the distance from the retina calculated so truly, as to subtend on it a visual focus, in which is a perfect repre- sentation of external bodies. The formation of this organic optical apparatus, constructed in the foetus included in the ovum or uterus, excluded from the direct operations of the physical forces except heat, it is affirmed, is absolutely inexplicable by the physical forces, or by any known physical process or actions. The insuperable difficulties presented by these facts, it is sought to evade by assuming that, as the causes of physical actions are unknown, and that new physical phenomena may be discovered, a resort to a new force is useless and unscientific. But it will not be pretended that the causes of physical actions will ever be better known than they are at present; and, whatever new physical actions may be discovered, they cannot differ in their nature from those of the present known physical actions. They will be unable to furnish any new light to solve the nature and origin of phenomena that reach far beyond the range of the physical forces; to which physical forces and actions are accessories, but cannot hold the relation of productive causes. From the admission by Dr. Lehmann, in his argument " that a new force may be assumed in science, whenever groups of pheno- mena are inexplicable by any known forces," the assumption of an organic or vital force, as distinct from physical forces, and as presiding over the developments of the organic forms of living beings, is an authorized and legitimate deduction. A third argument, and the last that will be noticed as having a bearing on the question is, "that the idea of a vital force is illogical; for a force is merely the abbreviated expression of a law from which the causal connection of certain phenomena may be deduced; and that a vital force corresponds to no law." This statement proves that Dr. Lehmann has not investigated the physiological facts of embryology or organic development, or he could not have so broadly asserted that the vital or organic force dr. lehmann's doctrine of vital forces. 45 corresponds to no law, and is not a necessary cause of multitudi- nous consequent phenomena. So far is this statement from being correct, it may confidently be asserted that the evidences of law, of causal connection and depend- ence are as strong, as palpable, in the phenomena, the direct results of organic or vital force-those of organization-as are to be found in any of the physical forces. A few facts will prove this position. Prevent the spermatozoon from reaching the egg, no monadiform germ cell, the primary form of all animals, is produced. Let this germ cell be artificially broken or injured, and no blastoderm will be formed; injure the blastoderm, and either no embryon and chick will be developed, or this last will be imperfect. Here are law and causal dependence and connection. Professor Owen, in his Hunterian Lectures (ed. 1855), has demonstrated that " every animal, in the course of its development, represents some of the permanent forms of animals inferior to itself, but it does not successively repeat them all, nor acquire the organization of any of the inferior forms which it transitorily typifies. One organic form, the microscopic infusorial monad, is either permanently or transito- rily represented throughout the animal kingdom. Other forms are represented less exclusively in the development of the animal king- dom, and may be regarded as secondary forms. These are the polype, the worm, the tunicary, and the lamprey. They are second- ary in relation to the animal kingdom at large, but are primary in respect to the primary divisions or provinces." In the above statement is demonstrated the subordination to a law, to a great overruling force in the organic world, on the pre- sence and action of which depend the type of organic forms, and the order of development of animal organisms. In the immutable harmony of organic nature, in the unchangeable characters that mark the distinction of species, genera, families, orders, and classes, are displayed unmistakable signs of the opera- tion of laws, of causal connections and dependency. Cuvier demonstrated the persistence, as he believed the permanency of species, and certainly the permanency of genera and families, by his anatomical researches. Goethe, as it were by a philosophical inspira- tion, had previously conceived and evolved the idea of the "Unity of Organization." In 1790, he enunciated the generalization, that " all the parts of an animal, taken together or separately, ought to be found in all animals." This deep-reaching thought of the 46 REMARKS ON" philosopher anteceded the empirical demonstration of the anato- mist. Oken and Geoffroy St. Hilaire struck on the same vein of thought, and by their researches and investigations established its truth, and made it the crowning fact of organic science. This widest and boldest generalization in natural science is, in the organic world, what Newton's law of gravity is in the universe. In the infinitude of the phenomena and forms and beings that compose the organic world, the universality and dependence of causal connections and special law, and in the evidences of its ever-during beauty, order, and harmony that pervade organic nature, is demonstrated the supremacy of a dominant force, far transcend- ing the physical forces in the higher nature of its productions, and more exalted character of its powers, influences, and relations. In its operations it appears as a ray emanating from the divine intelli- gence, stamping on each created living being types of organic structures, a revelation in material forms of the creative ideas of the Eternal Artificer of the universe. That force cannot be more appropriately expressed, than as the Organic or Vital force. This conclusion will no doubt be condemned as unscientific by physicists generally. In the present state of knowledge, the inexplicable and inconceivable in the physical, and still more in the physiological sciences, constantly cross our path, and arrest our investigations. Knowledge, science, philosophy, have their ultima thule, beyond which lie the vague and dreamy realms of conjecture. The sciences are the facts or phenomena discovered in the order of their connection, and interpreted by man's intelligence, such as they exist in the world exterior to itself. Indissolubly connected, they form the circumference of a vast circle, each advancing as it progresses, and is developed like radii, and meet in one common centre. That centre is the incomprehensible, the infinite; it is the first Eternal Cause-the creative God! It is always to me an assurance that the line of inquiry pursued is the true one, when its direction tends obviously to this termina- tion. Whenever investigation is turned from this course, it is invariably lost in misty and groundless hypotheses. In dissenting from the author's views of organic or life force, there has been no purpose of disrespect, or intention to undervalue his knowledge and the authority of his opinions on the special branch he has cultivated. It has been rendered necessary by the manner in which the subject has been treated. Almost exclusively DR. LEHMANN'S DOCTRINE OF VITAL FORCES. 47 physiological, it has been handled as a chemical question. All that has been urged by the author as to the extent, variety, and import- ance of the chemical actions and influences of chemical laws in the living organism is perfectly just; but to force chemical affinity and its laws from their appointed ordinances in nature, is not correctly scientific, and leads to serious errors and misconceptions. Yet such a perversion, it strikes us, takes place when physics and chemistry are summoned to explain the origin and the permanent constitution of the typical forms of organization, differing so widely from the molecular processes and actions, exclusively the results of their special activity and energies in the plan of creation. In adopting the handbook of Dr. Lehmann as a manual of organic chemistry for the use of the students of the University, and in recommending his original work of physiological chemistry for their more mature studies, the high value of his researches and the great weight of his authority, in that important department of medical science, are fully recognized.