Extra-uterine Pregnancy and its Treatment by Elec- tricity. BY ELY VAN DE WAEKEE, M.D., SYRACUSE, NEW YORK. REPRINT FROM VOLUME XII ejgnecolofltcal ^Transactions. 1887. EXTRA-UTERINE PREGNANCY AND ITS TREATMENT BY ELECTRICITY. ELY VAN DE WABKEB, M. D., Syracuse. The group of pelvic symptoms which lead us to recog- nize the presence of extra-uterine pregnancy, the proper time for interference with the viability of the ovum, the intensity and duration of the electrical current when employed to destroy it, the recognition of its death, and the after-be- havior of the pelvic mass by which we are able to confirm the previous diagnosis, are all matters of accumulated experi- ence, and not in any sense that of argument or opinion. That the subject has not completed the elementary stage of its literature, the following extract from a recent paper in the leading American special journal will prove. It is the report of a case of abdominal enlargement in which a diag- nosis of abdominal pregnancy of the fourth to fifth month was made. Ten applications of the galvanic current, of from six to eighteen cells, lasting ten minutes, were made; " so that, in three weeks from the first use of the galvanic cur- rent," and here is the remarkable part of the statement, " there was nothing left of the enlargement of the abdomen but a small lump on the right side, which proved to be the fundus uteri," and notwithstanding "that the abdomen was enlarged as high as the umbilicus." Here we are asked to accept as a fact that the entire mass of a five-months' fetus, with its fluid and solid annexes, were completely absorbed in three weeks, half of which time was occupied by the period of treatment, all of which, if true, were the contents of a sac 2 EXTRA- UTERINE PREGNANCY. destitute of the machinery of absorption. It is the record of such facts as these which led me to remark that the ele- mentary literature of the subject was not completed, and in- duces me to narrate the following case: Mrs. X., aged twenty-seven years, has had delicate health since an attack of scarlet-fever at eighteen years of age. Mainly these errors were pelvic in their origin, consisting of menstrual neurosis, which existed rather as crises in the per- sistent ovarialgia and sacralgia. During this period she led quite an active life,'but was sure each month to pass several days in bed. She married at twenty-four years of age, without producing any material effect upon either the pelvic symptoms or general health. She aborted of a three-months' fetus in 1885. In June, 1886, she came into my hands. She was leading quite an active life, giving much time and strength to society en- gagements. She was pale and anemic, with uncertain appe- tite. Examination showed a minor degree of retroversion, which appeared the only objective error I could detect. Sub- jectively the entire pelvic space was hypersensitive, more so upon the left side than the right, as is frequently the case. There was no restriction to uterine movement, and yet, on giv- ing the vaginal portion a right-and-left to-and-fro movement, a reflex, narrowly-defined pain was elicited in the right side as high as the umbilicus-the seat of frequent pain on driving or walking. The pelvic space was free from induration or tumors. Menstruation was regular, lasting about five days, and rather scant. She last menstruated regularly on July 25th. On the after- noon of August 28th she was attacked with severe pain, begin- ning in the pelvis, and rapidly extending over the abdomen. There were some signs of collapse, which quickly disappeared on the free use of morphia hypodermically. On the following morning what was taken for menstruation made its appearance, having gone six days over the usual period. There was con- siderable abdominal tenderness, dysuria, and painful defeca- tion. Matters continued in this state until September 7th, when another outbreak of pain took place, which required sev- eral hypodermic injections of morphia to relieve. Following ELY VAN DE WARNER. 3 this outbreak was such a degree of hypogastric and intra-pelvic tenderness that an examination was extremely unsatisfactory. Paroxysms of pain occurred on the 10th and 14th of Septem- ber, and meanwhile metrorrhagia in moderate amount was con- stantly present. On the 17th a decidua was passed with but little pain. It was a complete uterine cast, about three inches long, an inch and a quarter wide, and its w'alls a quarter of an inch thick. This was followed two days later by an explosion of severe pain. Her physician attended her usually during these paroxysms, but, as he had more than usual interest in the case, I was sent for to make a thorough examination. A small tumor was readily detected lying to the right and slightly pos- terior' to the uterus. Combined palpation showed that it was situated either in the right tube or broad ligament. It was, to estimate the size, two inches long by an inch and a half in di- ameter, sharply defined, the walls tense, and 'conveying to the touch the sensation of fluid contents. The uterus was dis- placed to the left anteriorly, and moderately fixed. There was considerable tenderness in and about the tumor. The out- breaks of pain, the metrorrhagia, the casting of the decidua, and the tumor aroused at once the suspicion of ectopic preg- nancy. . The breasts gave negative symptoms, nor could any corroborative evidence be gained in any other direction. On September 19th, 23d, 25th, 26th, and 29th, there were paroxysms of pain, but of lessened intensity. There was a lull in the more active symptoms until October 4th, when there was a renewal of the pain, with an increase in the flowing. The next day Dr. Mann, of Buffalo, saw her with a view of confirming my diagnosis of the case, as I hesitated to expose the patient to the pain and danger of powerful faradisation without an expert opinion other than my own. When Dr. Mann had examined the decidual cast, he remarked that he would not hesitate to pronounce it a case of extra-uterine preg- nancy on its appearance alone, as it was so characteristic of the accident. After a careful examination of the patient, he con- firmed my diagnosis. The next day, the 6th, we began the electrical treatment. The tumor by this time had doubled in size. The uterus meas- ured three and a quartex* inches, and was displaced to the left 4 EXTRA-UTERINE PREGNANCY. and forward, so that there was some bladder irritation and strangury, while the mass pressing backward into the rectum caused defecation to be difficult and painful. It did not require deep palpation to define the mass as occupying the entire ex- tent of the right tube. We had a powerful induction coil, with two zinc carbon cells, employing the full force of the secondary current. The tolerance of the pelvic region to the pain of the faradic current is remarkable. The irritation of the current from our induc- tion coil was such that it could not be tolerated elsewhere about the body for a moment, but our patient could bear it fairly well, provided the external electrode was firmly held with uniform pressure. She had ten seances of half an hour's duration each on the same number of consecutive days. During this period the pain continued in paroxysms, not uniform in intensity, but varying from day to day. The metrorrhagia continued ; the pelvic hyper-sensitiveness was unchanged, and rendered the application of the electrode additionally difficult and painful. On the pelvic mass there was no evidence that I had made any impression whatever. Its size remained the same, and its re- sistance to the touch, or what I would prefer to term tension, was unchanged. As neither her physician nor I was satisfied that the cur- rent had killed the fetus, we resolved to follow Dr. Mann's advice, and prolonged the treatment to one hour. Begin- ning on October 20th, we did so for three successive days, using the full strength of the induction coil. On the third day we found evidence that the electricity was accomplishing its work. After the first one-hour treatment the paroxysms of pain ceased ; there was pain, to be sure, but it had lost its ex- plosive character, and was the result of the mechanical effect of the mass. The most important evidence was a lessened ten- sion in the cyst-wall. We are told to look for a shrinkage in size as the first symptom of the death of the fetus, but it is an exceedingly difficult matter to determine slight differences in size of a small intra-pelvic mass, which from the nature of things must be palpated with great care and gentleness. It was weeks after that before we could say positively that it was any smaller, but from the time mentioned I could say without ELY VAN DE WARNER. 5 doubt that it -was softer. I believe this to be a sign more easy of early detection than shrinkage ; and, as shrinkage is evidently the result of diminished tension, it follows that the latter will be first evident to the touch. At least, it was so in this case. Another matter that appears important is, how far we are to regard the persistence of paroxysmal pain after begin- ning the electrical treatment as evidence of the viability of the ovum. I have read reports of cases in which the pain ceased partly or completely after one or two treatments. We were working in expectation of such a result, but it failed. I do not believe there was anything to criticise in our appli- cation of the current. The inner electrode was a small cone pressed directly against the vaginal expansion of the cyst; and the outer, a flat disk an inch in diameter, covered with cham- ois wet in water and applied to the part of the cyst most evi- dent by external palpation. Pain of an intense and explosive character might persist after the death of the fetus; but, if the theoretical explanation of pain of this character is true, namely, that it is due to steady expansion of the cyst-wall by a growing fetus, it ought not. Inasmuch as the cyst has been repeatedly known to rupture during an attack of pain, it would follow that it was caused by either expansion in its contents or contraction in its wall, or rupture in greater or less extent. Under the former, when the viability and growth of the fetus ceases, pain ought to stop, and under the latter explanation it might readily continue. There are sufficient muscular filaments in the expanded tube to explain intermit- ting and painful contraction after the arrest of fetal growth. So doubtful were we of the results that I kept sponges, liga- tures, and instruments ready packed to make laparotomy at any moment. My case does not make plain which of the two explanations was the true one, but the fact was evident that the paroxysms ceased when tension of the cyst diminished, a result obtainable under either conditions of the cyst-wall or contents. Was it necessary to continue the use of the current to the 6 EXTRA-UTERINE PREGNANCY. extent that we did is an important and practical question ? Might we safely regard two or three transmissions of the powerful current we were using as sufficient ? I was in doubt then ; I believe that I know more about it now. I was called in consultation since the above in a case of chronic albuminuria in a young married woman, believed to be about three months pregnant. In her last confinement she had such a narrow escape of her life from the same cause that I did not hesitate to give the opinion that the production of abortion was justifiable. While in London during her second pregnancy the late Dr. Meadows gave the same opinion. I used the fara- dic current to cause the death of the fetus. An olivary- pointed metallic electrode was inserted in the os externum, and a small sponge electrode held over the uterine fundus exter- nally. . The current was from an induction-coil of a Waite & Bartlett cabinet battery run by four Leclanche cells. The full force of the coil was gradually turned on for half an hour every third day, and it required six seances before the subjective symptoms of pregnancy ceased, followed a week after by an easy and very safe abortion. Contrast with this a still later experience: A young woman twenty-nine years old had suffered from a large, non-fluctuating, intra-pelvic tumor for several years, de- veloped posterior to the uterus. It was difficult to curve the finger over the mass, and reach the cervix. She very impru- dently married, and about the first experience she met with after that event was pregnancy. Iler physician brought her to me, and we both agreed that to permit the pregnancy to go on gave her no hope for delivery at full term except by lapa- rotomy. This time I used the galvanic current, being dissatis- fied with my experience of the faradic. A strength of 50 mil- liamperes was used. An olivary electrode covered with cotton was pressed against the os externum, which was reached with difficulty, and the external positive electrode was a flat sponge. The current was passed for fifteen minutes, and repeated on the third day, when the nausea ceased and the mammary signs abated, followed four days later by abortion. ELY VAN DE WALKER. 7 The current was given slow interruptions by a rheatome, so as to pass it through the uterus in a series of shocks. It was far more painful than the faradic, as the burning sensa- tion of the external electrode was severe. The electric cur- rent destroys fetal life by inducing permanent molecular changes, and its power to reduce vital as well as non-vital compounds to their ultimate constituents, and thus rendering the process of life impossible. We do not expect to attain this result by the faradic form of the current, which has no electro-chemical force, but by the galvanic, which we know in its various degrees of intensity will induce such molecular and chemical changes as to destroy any form of life. The faradic current acts by a series of shocks that, continued long enough and repeated often enough, will cause fetal death. Hence I have come to the conclusion that I did not continue the use of electricity unnecessarily long, and that in all cases in which electricity is used to attain this end, it ought to be continued until this is indicated by some objective or subjective evi- dence. I say this in the absence of any evidence whatsoever of the character or quantity or intensity of current necessary to destroy the fetus in ectopic pregnancy. A word or two concerning the subsequent behavior of the cyst. It was seven months before one might say, by exter- nal and internal palpation, that no further trace of it could be detected. Having regard to the nature of the sac and its contents, this appears to conform to the normal. It would take about the same length of time for an inflammatory exu- date to disappear by absorption, and neither the sac nor its con- tents in electopic pregnancy is exposed to the same function in equal degree, to say nothing of its more difficult absorp- tion owing to the higher organization of its elements. Mild galvanization to the extent of ten milliamperes appear to con- siderably expedite the absorption. To say, then, that a five- months' fetus and its cyst could disappear to a mere trace in three weeks must be an instance of a fact observed obliquely. One other fact in the after history of this case is to me diffi- cult to account for, but may be important as an item of ac- 8 EXTRA-UTERINE PREGNANCY. cumulated experience. The metrorrhagia that attended the active phase of the case has continued in a very passive form nearly constantly. It is just sufficient usually to cause a small stain upon a napkin, although until about four months ago it occasionally would cause her to change three or four times a day. The discharge is dark, containing minute granular mat- ter, and is never offensive. Menstruation is regular and the discharge totally different in character. Blunt curetting and intra-uterine applications of Churchill's tincture produced no effect. Multiple tampon with antiseptic wool has done more good than any other treatment.