THE TREATMENT OF THE VffiOUS FORMS OF CONJUNCTIVITIS AS PRACTISED AT THE GERMAN HOSPITAL, READ BEFORE THE PHILADELPHIA COUNTY MEDICAL SOCIETY, DECEMBER 27, 1893, By LOUIS J. LAUTENBACH, A.M., M.D., Ph.D. PHILADELPHIA. chief of the eye clinic of the german hospital ; surgeon TO THE PENNSYLVANIA EYE AND EAR INFIRMARY ; THROAT AND NOSE PHYSICIAN TO THE ODD FELLOWS' HOME, ETC. Reprinted from the Transactions of the Philadelphia Medical Society for 1893. To which is added a Report of the New Patients in the Eye, Ear and Throat Departments of the German Hospital from their Inception. PHILADELPHIA: J. B. Smith, Printer, 2160 N. 21st St. 1804. Reprinted from the Transactions of the Philadelphia County Medical Society for 1893. THE TREATMENT OF THE VARIOUS FORMS OF CONJUNCTIVITIS AS PRACTISED AT THE GERMAN HOSPITAE. READ BEFORE THE PHILADELPHIA COUNTY MEDICAL SOCIETY, DECEMBER 27, 1893. By LOUIS J. LAUTENBACH, A.M., M. D., Ph. D., PHILADELPHIA, CHIEF OF THE EYE CLINIC OF THE GERMAN HOSPITAL ; SURGEON TO THE PENNSYLVANIA EYE AND EAR INFIRMARY ; THROAT AND NOSE PHYSICIAN TO THE ODD FELLOWS' HOME, ETC. My connection with the Eye Department of the German Hospital dates back to a period of some three and a half years, during which time somewhat over five hundred cases of conjunctivitis have been treated in the clinic. This does not include the cases of hyper- aemia of the conjunctive or of symptomatic conjunc- tivitis, so often observed as a consequence of eye strain from refractive disturbances, nor are these cases recorded in the hospital reports, except as to their refractive error. The Eye Department of the German Hospital is under the charge of Dr. Charles S. Turnbull, under whom I serve as Chief of Clinic, and to whom I am indebted for much valuable aid and advice as well as encouragement, 2 TREATMENT OF CONJUNCTIVITIS. The table here presented gives the number of cases of all the forms of conjunctivitis presenting themselves at the clinic during the years of 1891, 1892 and 1893- a total of 432 cases, as compared with 317 in the years of 1888, 1889 and 1890, showing the clinic to be a growing one, although not rapidly so: 1891 1892 1893 Total Conjunctivitis, Acuta .... . 22 32 29 83 '1 Subacuta . . . . 20 6 6 32 " Chronica . . . • 29 30 36 95 '1 Blennorrhoea . • 7 4 7 18 " Epidemica . . • 17 13 19 49 '1 Erysipelatous . . - - 1 1 " Follicularis . . . 8 3 15 26 " Fhlyctenulosa . . 8 9 23 40 " Trachoniatosa . • 3i 22 19 72 " Traumatica . . • 5 6 5 16 Totals, . . 147 125 160 432 The classification of the various forms of conjunc- tivitis varies with the ideas of different authors-no two seeming to use the same nomenclature-their vary- ing views depending, in the main, on the different pathological opinions held by each. For instance, epidemic catarrh is by many classed as a simple acute catarrh. The classification here presented makes no pretence as to being strictly scientific, but will com- mend itself as being thoroughly practical. Now, it is not my desire to take up each of these forms individually and study it separately and com- pletely, but rather to indicate some general rules about the treatment; some few thoughts which have come to be very important truths, and to indicate, wherever necessary, any modifications or additions. TREATMENT OE CONJUNCTITITIS. 3 The first step in the treatment of all cases of con- junctivitis is necessarily the cleansing of the conjunc- tiva, not simply the ocular or the palpebral portion, but of the whole conjunctiva including the folds-the lower palpebral fold especially. This necessity exists with the most acute as well as the most chronic, the simplest as well as the most complicated case. It is the key-note of the treatment. If we endeavor to cleanse and do not succeed in thoroughly doing so, we may cure many of our cases, but will not get as prompt nor as good results, and many cases we will find it im- possible to cure. For instance, while we may be suc- cessful with the simple catarrhs, we will often fail in the epidemic form, and in gonorrhoeal conjunctivitis we will invariably fail. How is the conjunctiva to be thoroughly cleansed? How is it best accomplished ? My method is to invar- iably cleanse first by means of Peroxide of Hydrogen, which I use in full strength, 15 vol. solution (testing over 10 vols. invariably). Now the pure peroxide stings considerably when used on the conjunctiva, often inconveniencing the patient very much, and when the solution is markedly acid it is far more painful, and indeed, is then unfit for use in the eye. The reason that this remedy has, comparatively speaking, met with so little favor among eye surgeons has been mainly because of the marked acidity of many of the solutions. This acidity is not only a cause of much pain but, indeed, sometimes an element of danger, as the con- jestion of the conjunctiva occasioned, is sometimes sufficient to interfere with the proper nutrition of the cornea. 4 TREATMENT OF CONJUNCTIVITIS. Having used peroxide of hydrogen steadily for a period of almost ten years, I feel it but right to indi- cate the basis of my faith. I have in these years used various brands of the solution*. For a long time I relied upon the Marchand peroxide and found it fairly stable, but its acidity was so great as to prove a great bar to its use; indeed, very rarely could it be used in the eye without previously neutralizing the free acid. Later on I tried Bene's, and found this to answer my purposes very well, the acidity being still noticeable however. Among others, which I tried some three years ago, was that manufactured by the Oakland Chemical Co., and I to-day rely mainly on that prepara- tion. It is fairly constant in the amount of Oxygen it contains; fairly stable; is not much deteriorated by moderate changes in temperature; and the amount of free acid present is very small. It tests beyond io vols. invariably, usually from 12 to 16 vols. At the hospital I employ the Rosengarten brand and find that it and the Oakland are much the same in their action. Be- tween the two I can detect no marked difference. I lately tried Peuchot's, but find it entirely too acid to be used in the eye. Of all the kinds I have employed, having experi- mented with upward of a dozen, I can recommend for use in the eye only the preparations of Bene, of the Oakland Co. and Rosengarten's. The characteristics which these preparations have in common and which should be possessed by any peroxide employed, are first, invariably testing beyond 10 vols., preferably be- tween 12 and 16 vols. of oxygen; second, in being fairly stable-not losing their oxygen upon slight TREATMENT OF CONJUNCTIVITSI. 5 changes of temperature; third, and most important: having little or no free acid present; the amount of acid should be as small as is consistent with the stability of the preparation. By the use of a pure preparation, the entire con- junctiva can be most thoroughly cleansed; not only will the discharge on the surface be washed off, but that lying in the crevices and chinks will be decomposed and washed out. A word as to the method of use. From io to 30 drops of the solution should be instilled at the outer canthus and the eye then closed, and with the fingers a degree of massage applied over the entire surface of both eyelids. Then the eye should be looked at, and, if necessary, a second, a third, and evena fourth appli- cation should be made. Often in trachomatous cases, after its application, it is well to evert the trachomatous lid, and, with the rubber end of an eye dropper, rub its conjunctival surface. The thorough application of the peroxide should invariably be followed by the liberal use of a saturated solution of boracic acid. This will wash out all the debris and soothe the possibly irri- tated conjunctiva. This treatment I never intrust to the patient, but always do it myself, using it as often as necessary from twice a week to once or twice a day. Occasionally I allow a patient to use a weaker solution of the perox- ide, from a three to an eight volume solution, but never stronger, used once or twice a day. The cleansing method that I advise the patient to follow is the liberal use of a saturated solution of boracic acid as a wash or eye bath, used almost invariably as hot as the eye can 6 TREATMENT OF CONJUNCTIVITIS. bear, from two to eighteen times a day, even every half hour in many gonorrhoeal cases. Having thus thoroughly cleansed the conjunctiva, we have a surface upon which we can apply our appropriate remedies pnd are sure they will have the maximum effect. Not that it will always be neces- sary to employ anything beyond the cleansing before indicated, as indeed we will find many mild cases of conjunctivitis yield through these simple means. In cases of acute conjunctivitis, when further treat- ment is indicated, we direct the patient to use a mild solution of acetate or sulphate of zinc, or a solution of borax in camphor water, advising the hot boracic acid solution as a wash. In sub-acute conjunctivitis we employ usually either the solution of sulphate of zinc or of copper. In chronic conjunctivitis especially if there be much thickening of the conjunctiva, I direct, in addition to the treatment employed in the sub-acute cases, the use of massage on the eyelids three times a day immedi- ately following the instillation of castor oil (the oil to be used after the eye has been thoroughly bathed with hot boracic solution and roughly dried). The persist- ence in this method has, in numerous cases, been fol- lowed by what might almost be termed marvelous results. In conjunctivitis blennorrhcea or gonorrhoeal con- junctivitis, the peroxide treatment is to be used regu- larly once a day, and in very virulent cases, twice a pay. It is to be followed by the boracic acid solution, TREATMENT OF CONJUNCTIVITIS. 7 and this in turn by a strong solution of nitrate of silver brushed upon the lids with a small pledget of cotton on a cotton holder. I never employ brushes as I con- sider them incapable of being kept clean. Upon the first visit, I usually use a solution of 60 grains to the ounce; on the second day, if necessary, I employ the same solution, or may even use a solution as weak as 5 grains to the ounce, or any strength between the two. Of course, in using such strong solutions, care must be taken to limit its action to the conjunctiva-not to allow a drop of it to touch the cornea, and to neutral- ize any excess of solution immediately. If there be much conjunctival swelling, especially of the circum- corneal conjunctiva, and particularly if this threatens the nutrition of the cornea, I scarify this freely in sev- eral places in lines radiating from the cornea. After the use of the nitrate of silver, again wash with bor- acic acid solution and send the patient home, with directions to wash the eye with hot boracic acid solu- tion either every 30 or 60 minutes as circumstances demand, and to use 2 drops of a two grain solution of nitrate of silver twice a day, and report the next day. Since adopting this method I have not had a case to resist a cure for over seven days, and in one instance, had a perfect eye after three days. I invariably direct these patients to use smoked glasses, as they, in addi- tion to protecting the eye from the dust, light and wind, prevent him from wiping them as much as he otherwise would. Epidemic conjunctivitis is treated in much the same way, except that the peroxide and boracic acid solu- tions are followed by a solution of nitrate of silver of 8 treatment of conjunctivitis. five grains to the ounce, and the patient is directed to bathe the eye with boracic acid solution every hour or two, and to use a one grain to the ounce solution of nitrate of silver twice a day, and to wear smoked glasses. In follicular conjunctivitis the cleansing is the same. This may often be followed by the application of the alum stick, or sometimes the follicles are opened, or castor oil may be used by the massage method; the patient is directed to use the hot boracic acid solution as a wash three or four times a day, and the castor oil after each cleansing; again, at times, I direct an ointment of acetate of lead, one grain to the ounce, to be used in the lower lid at night. Of course, this is never to be ordered without cautioning the patient never to use the ointment for any other treatment than the present one, as it is never to be employed unless the cornea be intadi. In conjunctivitis phlyctenulosa, the cleansing is employed as above and is followed by the use of atropia, and this again, perhaps, by calomel. The patient is directed to use the hot wash four times a day with, perhaps, a weak solution of atropia and the yel- low oxide or mercury salve at night, protecting the eyes by means of smoked glasses. In conjunctivitis trachomatosa, the cleansing is in- variably very thoroughly employed, any source of irri- tation, such as misplaced cilia is, if possible, removed; all trachoma present are opened and thoroughly scraped out, any contracting bands being superficially incised and redundant tissue, if present, removed. After this peroxide is to be employed; to be followed, if neces- TREATMENT OF CONJUNCTIVITIS. 9 sary, with alum, sulphate of copper, or nitrate of sil- ver in stick. The patient is directed to cleanse the eye thoroughly and frequently with hot boracic acid ; to, in some cases, use castor oil with massage, either alone or in connection with the yellow oxide of mercury ointment at night; treating sequelae as they arise. In connection with the above local treatment there should be employed whatever general treatment may be found necessary. This is indeed often of the utmost importance in this class of patients. We will not here enlarge upon this subject. Each patient is a law unto himself and must be treated accordingly, but the key- note should be to rectify any abnormal conditions need- ing correction, and to restore the body to as nearly a normal one as is possible. The above is necessarily but a brief outline. It has been presented thus with the objedt of calling atten- tion to what I deem the foundation stone of the suc- cessful treatment of inflammation of the external parts of the eye-cleanliness and thoroughness. It is a truth which holds good in the treatment of the cornea as well as the conjunctiva. I wish to call attention to the method of obtaining cleanliness-the most thorough with which I am acquainted; and secondly, to the use of massage as one of the efficient but little used methods of treating conjunctival affections, especially conjunctival thickenings. Medicines prepared as oint- ments or as solutions in some oily menstruum lend themselves readily to this mode of treatment; thirdly, I have desired to call attention to the wonderfully suc- cessful results of the above treatment of gonorrhoeal conjunctivitis; and fourthly, I have wished to call 10 TREATMENT OF CONJUNCTIVITIS. attention to the method in phlyctenular cases, as upon numerous occasions we have had cases which having proven unusually intractable at other hospitals, have readily succumbed under our method. In cases of phlyctenular diseases involving the cornea, this has been more often and more thoroughly illustrated than in the simple conjunctival cases. I recall two such cases now under treatment. One of a boy of twelve, who in a month, has obtained a better result than had been accomplished at any time during the past ten years of almost continuous treatment at other institu- tions in this and other cities. Upon several occasions, he was house patient at various eye hospitals. The other, a parallel case, is the one referred to in my paper on phlyctenular conjunctivitis in the Rhode Island Medical Society Monthly, November, 1893, page 53°- The conclusions which I have reached as a result of my hospital work are: that in these cases, thorough- ness, especially in cleanliness, is essential; that the entire conjunctival cavity must be effectually cleansed and prepared for any such curative agent which we may desire to use; and in addition to this, the patient should be directed to keep the eye as clean as is possible, but necessarily he can not do this as thoroughly as we can. Every case should be seen as often as necessary; in cases of doubt, have the patient come rather too often than not often enough. If necessary for the welfare of the case, donate some of your time at your office ; do for him all you can and always as thoroughly as neces- sary, even more so. If you fail at all, fail in doing for him too much. The results thus obtained will sometimes be unexpected, but ever gratifying. TREATMENT OF CONJUNCTIVITIS. 11 The Eye, Ear and Throat Departments of the Ger- man Hospital have clinics two days per week (Tuesdays and Fridays). The time to be devoted to the clinic work is presumably one hour, but it is upon rare occa- sions only that from two to three or more hours are not consumed. Considering the number of clinic days (100 in the year 1893), it will appear from the accom- panying table that the number of new patients in the Eye Department is not a meagre one. It will indeed compare most favorably with that of any general hos- pital in Philadelphia, and compared, even with the special hospitals, its record is by no means a poor one. Of course, as contrasted with the New York Ophthal- mic and Aural Institute, under the charge of Dr. Her- man Knapp, with a record of 6,961 new eye patients in 1893, largest number of any institution in this country) our number of new cases (910 in 1893) may not seem very great, but one must not forget that this dis- pensary is situated in the heart of the metropolis of America; that it has a daily service; that it is over 24 years old; that it is a special hospital with a large build- ing, fitted with all necessary and convenient appliances; and that it is under the charge of one whose reputa- tion is world wide and who has the aid of numerous assistants. The record of 910 new eye patients treated at the German Hospital during 1893 is, under the conditions there present, a vary gratifying one, and one which has never been equalled in the history of the hospital. The eye and ear departments were opened in 1883, while the throat clinic was inaugurated in 1888 by (Dr. A. A. Bliss, who still has charge of the same). 12 TREATMENT OF CONJUNCTIVITIS. Since 1890, all eye patients under 12 years of age have been referred to the clinic opened at the Mary Drexel Home, which is now under the charge of Dr. George Friebis. Number of New Patients treated in the Eye, Ear and Throat Clinics of the German Hospital: Eye Patients, 1883 1884 1885 1886 1887 1888 1889 1890 1891 1892 1893 Ger. Hospital, 304 425 617 441 701 642 654 602 723 677 764 Mary Drexel Home, * * * 166 146 Total,843 910 Ear Patients, 124 165 207 145 177 260 222 226 199 186 183 Nose and Throat Patients, 128 210 198 * 288 232 * Not recorded in Annual Reports. 1723 Walnut Street, Phila.