A CLINICAL STUDY OF A CASE OF DOUBLE CHORIO-RETINITIS IN THE MACULAR REGIONS, FOLLOWING A FLASH OF LIGHTNING AND A FLASH FROM BURNING LYCOPODIUM. READ BEFORE THE 1896 MEETING OF THE AMERICAN OPHTHALMOLOGICAL SOCIETY. BY CHARLES A. OLIVER, A.M., M.D., One of the Attending Surgeons to the Wills Eye Hospital; one of the Ophthalmic Surgeons to the Philadelphia Hospital, etc. Reprinted from the International Medical Magazine for October, 1896. I. Right eye. A CLINICAL STUDY OF A CASE OF DOUBLE CHORIO- RETINITIS IN THE MACULAR REGIONS, FOL- LOWING A FLASH OF LIGHTNING AND A FLASH FROM BURNING LYCOPODIUM. On the 27th of April, 1894, A. P., a twenty-year-old engraver and artist, came to my clinic at the Wills Eye Hospital, complaining of mus- cular and accommodative asthenopias. A week later the total error of refraction was most carefully and repeatedly obtained during several days' time by the use of atropine. Two weeks were then allowed to elapse before the formula for glasses was given. During the intervening time medium smoked coquilles were constantly worn, and no manner of near work was attempted. The correction ordered, which was for low grade or compound hypropic astigmatism, gave an acuity of vision aud a power of accommodation that were normal in each eye. Extra-ocular muscle balance for both far and near was restored from a slight esophoria to proper equilibrium. Just after the patient left the hospital with the formula for his glasses a violent electric and rain-storm suddenly appeared. The details of what now happened cannot be better given than in the exact words of the patient's own intelligent account. a On May 28, after being at the hospital to have the glasses examined which were ordered by Dr. Prendergast, of Dr. Oliver's clinic, I started home at 3.30 p.m. A heavy storm came up and there was a great deal of lightning. " While I was walking on Filbert Street, between Ninth and Tenth Streets, a flash of lightning which appeared like an electric arc light (that is, it was a blinding flash) passed from left to right in front of me. a A queer sensation came over me, and I thought every bone in my body was being wrenched from its joints, and I staggered. A horse, which was on the opposite side of the street fell, but regained his feet a moment later. For several moments I could not see ; ray eyesight came partially back, first in the left eye only. Gradually, in a minute or more's time, the sight returned in the right eye. I walked home apparently all right. " That evening, about half-past nine o'clock, I was exposed to a flash of light from lycopodium coming in contact with burning alcohol. I went to bed and was so restless that I could not sleep. " The following day I went to my work, which is that of engraving. 2 CHARLES A. OLIVER, M.D. I noticed on my work, or wherever I looked, that there was a small gray- ish spot. In the centre of this spot there was a second one about the size of a pin's head, and which was of the brightness of the sun. The central bright spot was fixed, while the grayish boundary moved rapidly in the direction shown by the arrows in the sketch.1 (Plate I., No. 1.) "At noon on the second day the spot changed to the shape shown in No. 2. The central spot was still bright, but the boundary was darker. The same character of motion continued as in No. 1, but it occupied a different position, as shown by the arrows. "During the evening of the same day No. 2 spot changed entirely. The central spot, which remained bright, divided into four parts that kept constantly revolving in and through each other. The outer area had become fainter, and seemed to be made up of radiations, which rapidly moved from the centre to the edge in radiary waves. Both varieties of motion with the rapidity." (No. 3.) The patient later stated that, during the time that these three figures were present, any series of narrow or closely-placed vertical lines would appear unequally corrugated like broken waves. The lower extremity of each broken line seemed to vibrate both to the right and left and to the left and right in a similar manner to the movement of a pendulum of a clock. Each excursion was short and the motion was very fast. The upper portions of the broken lines remained stationary. On the afternoon of the 6th of June, just nine days after the accident, he came to me at the hospital, and I had my first opportunity of examining him. At this time he gave me the first seven sketches. He told me that the flash of lightning, which appeared purple, seemed to strike the pave- ment directly in front of him, and for several hours aftewards a grayish- colored area, which prevented him from seeing a man's head, persisted before each eye and then gradually disappeared. The lycopodium flash did not seem to leave any immediate after-effects. As noted in his own account of the case, the central scotomatous and irritation-area appeared on the follow- ing day and continued for seventy-two hours. For a period of three days he had very little if any trouble, although his employer had several times complained that his engraving was imperfectly done. On the 3d of June, three days before I saw him, the irritation-scotoma again appeared before the right eye. As shown in No. 4, the patient stated that " the small brilliant spots had increased to seven, and the surrounding grayish area had become somewhat Maltese-cross shaped. The bright spots were constantly moving through one another like minute electric balls, without leaving any trail." 1 " The spots are as I look at them, and are the exact size and shape. I have taken great pains in preparing these drawings, and they are correct." (All of the succeeding subjective studies were made with the objects situated at twelve or more metres' distance from the eye.) II. Right eye. CASE OF CHORIO-RETINITIS IN THE MACULAR REGIONS. 3 On the following day "the large spot, as partly shown in No. 5, which still remained fixed, became darker, and the included bright spots were changed into a great number of rapidly and irregularly moving hair-lines of brilliant light." The succeeding day showed (No. 6) that a great change had taken place. The scotomatous area had become somewhat fainter, had increased in size, and had become stellate in form. The radii were massed into bundles that were situated upon different planes. The contained bril- liantly-lighted lines were converted into eleven small spots of the same shape and size as the seven shown in No. 4. Like those in No. 4, the spots had become aggregated centrally, and were undergoing the same character of inosculating motion. Early in the morning of the day that I saw him the remarkable change shown in No. 7 appeared. To quote from the patient's own written statement: " This change came suddenly. I had retired early the night previously, at which time the spot was like that shown in No. 6. I could not sleep much until towards morning. I arose at seven o'clock, when, to my surprise, the spot was like that shown in No. 7. The slightly eccentric light area was not brilliant, but had the appearance of frosted glass. The surrounding area was as black as ink. The large faint peripheral area seemed to me like a fog. The entire mass was motion- less." He stated that any decided movement of the left eye produced a deep- seated pain in that organ. Central vision for form with the right eye was reduced to one-fortieth of normal. The field of vision, which was normal in size, gave marked evidences of a large irregular central scotoma that was absolute for both form and color. The pupil was the same size as that of the fellow appar- ently undisturbed eye, and the iris was as freely mobile to light-stimulus, accommodation, and convergence as its fellow. The left eye seemed normal in every respect. The ophthalmoscope revealed a most striking and never- to-be-forgotten picture in the right retina. Directly in the macular region the retinal tissue seemed to be slightly puffed into an irregularly flattened mass. The tissue itself did not appear to be discolored or opaque, but glistened in places as though the underlying material were composed of an extremely thin coating of cicatrizing, almost transparent jelly. No hemor- rhages of any character could be detected, and no signs of degeneration of any type, except that the nerve-head was a trifle hazy and gray, could be deterjuined. The retina of the left eye apparently was not affected in any way, ex- cept that here, too, the nerve-head was a trifle too gray for age and was somewhat hazy. The patient, who seemed strong and hearty, strenuously denied any syphilitic infection, and after the most careful physical examination failed to present any evidence of the disease. The only obtainable history of 4 CHARLES A. OLIVER, M.D. systemic disturbance was that of infrequent attacks of muscular rheuma- tism. In order to study the rapidly-changing symptoms, and to give his eyes a thorough rest, I admitted him into the hospital, put him to bed, and lightly, though effectually, bandaged his eyes, so as to exclude all extra- neous light from their interiors. I immediately placed him upon the free use of alteratives, thoroughly purged him, and gave him light, nutritious diet. The examinations were continued unremittingly each day, care being taken to give each eye a thorough rest before every new procedure. On the second day of his stay in the hospital he observed that the scotomatous area had undergone a marked change for the better. This is shown in No. 8. In his own words, "There is some change in the general shape of the spot. The small white spot is a little larger, and the sur- rounding black area is a little lighter. The foggy appearance around the spot has disappeared." He complained that the eyeball pained him con- siderably. Both central and peripheral vision practically remained as before. To his great dismay, he, for the first time since the primary momentary blinding at the time of the accident, noticed a central scotoma before the left eye. (Plate V., Fig. A.1) He informed me that "it had appeared synchronously with the twisted, snake-like appearance before the right eye. To him it closely resembled drawing No. 3 seen with the right eye, and had the same characters of motion. On the 11th of June, at my suggestion, he presented me with two very interesting sketches. The scotomatous areas, studied in his ordinary way of projecting them against a distant white background,-as, for example, the clouds, a white shutter, or a pane of ground glass,-now gave him the peculiar ap- pearance shown in No. 9. As he remarked in his report, " The color is the same as that in No. 8, but the light place in the centre is larger, and I can see a very little through it." Acting upon this suggestion, I thought that I would try and see whether any increase in the distant illumination would make a change. To his great surprise, when I had him gaze at a large area of rather brilliant orange-yellow light obtained from ordinary illuminating gas, he found that the previous light central area iu the sco- toma became absolutely black, and the peripheral area, which was ex- tremely black in the previous experiment, now became quite faint and "pearl-colored." No. 10 shows very well what is meant. Several times during the experimentation, when the patient looked away from the flame, several brilliant triangular bodies which were in rapid vibration appeared in the scotomatous area. 1 In order to more readily differentiate the varying scotomata in the two eyes, all those that belong to the right eye have been numbered, and all those that were seen by the left eye have been alphabetically arranged. III. Right eye. CASE OF CHORIO-RETINITIS IN THE MACULAR REGIONS. 5 A careful drawing of the appearance of the same series of vertical lines that he had experimented with before his admission into the wards of the hospital gave the projection of a scotomatous area that was similarly- shaped to No. 9 directly upon them. A peculiarity, however, that he noticed was that the lower extremity of every one of the lines above the sco- toma was barbed upwardly and to the left, and the upper extremity of each of the lines below the scotoma was barbed downwardly and to the left. On this day the general form of the scotoma before the left eye had changed to the area shown in Fig. B. The six small brilliant spots kept moving in the same manner as the spots in No. 7. At his own request, I discharged him from the wards to the dispensary service of the hospital, ordering him to take twenty grains of iodide of potassium three times daily. On the next morning (the 12th of June) the scotoma presented the appearance shown in No. 11. As can be seen, " the foggy atmosphere," as he was wont to call it, in which the scotoma was situated, had dis- appeared. The central light area had greatly cleared, and the entire spot had become fainter, this being marked by " a heavy dark vein" which ran through the central portion of the larger dark area. At 1 p.m. of the same day the patient made a sketch shown in No. 12, and noted : " There is some change in shape, but not in color. There are two bright spots, like miniature suns, in the lower portion of the spot, and these, which are constantly vibrating, are exceedingly annoying. The eye pains me, and seems quite inflamed." Half an hour later the sketch of No. 13 was made. In the patient's diary I find: " The dark spot is about the same shape, but it is lighter* One bright spot has disappeared. The remaining one, instead of vibrating, throws a light up across the light area beyond the scotomatous area, leav- ing a series of overlapping concentric rings, somewhat like the tail of a comet." At 5 p.m. of the same day he made the sketch for No. 14, writing: " This makes the fourth change in one day,-the most that have taken place in one day. The bright spot has gone. I can see through the small central opening, but very dimly, as though it were covered with frosted glass. Everything seen through it, though not distorted, seems to be small and very far away." The sketch of No. 15 was made at ten o'clock the next morning. To use the patient's own language: "This morning another change has taken place, both in size and shape of the spot. It is larger, but is not any darker, than that of the previous sketch. The whole area appears like a piece of isinglass, but I cannot trace the shape correctly. By closing the eye rapidly I can see the shape. The opening is a little clearer. All ob- jects are very small and dim. The eight small spots outside appear as though they were broken-off* particles of the large spot. They are fixed." At 12.30, at noon, he made another most interesting sketch, shown in 6 CHARLES A. OLIVER, M.D. No. 16, and wrote: "Another change both in shape and size has appeared. The light spots have lessened to six, and instead of one large opening in the central blind area there is a more irregular and dimmer somewhat cen- tral one, surrounded by six little ones, four of which are situated in the prolongations." Two hours later sketch for No. 17 was made. Describing it, he said, " Another change, both in size and shape; all of the small areas have dis- appeared from the outside of the spot. The sieve-like openings in the large area have all, with the exception of the lower inner one, broadened into a large central light area partaking somewhat of the same general con- figuration of the large dimmed area." During this day he made two very instructive sketches, one of which was practically No. 17 projected against a series of narrow vertical lines. Not only was the scotomatous area present, but the lines themselves in the region of the scotoma were smaller, finer, and more closely packed together, thus substantiating his assertion that all objects looked at through the spot were smaller. A curious sketch showed that a vertically held string bulged forward and appeared somewhat attenuated in front of the scotomatous area. A drawing of a horizontally placed rectangle, made while looking at the object with the right eye, exhibited the same characteristic metamorphopsia and micropsia. The ophthalmoscope showed that the macular region was sur- rounded by a most curiously irregular and shining rim, the enclosed area being markedly depressed in places and quite pallid, especially the fovea itself, v On the 18th of June the left scotoma, as shown in Fig. C, appeared to be divided into four dull areas " which are in constant motion. The six vibrating, brilliantly-lighted spots have disappeared." Three days later (21st of June), at 4 p.m., the sketch shown in No. 18 came into existence. As the patient wrote : " This is the most peculiar shape and motion that I have had. It is about as dark as drawing No. 5. The small central clear spot which is fixed is about as bright as an electric arc light. The dark coma-like area surrounding it moves around the light spot in the direction shown by the arrows at about the rate of two revolu- tions per second. In a dark room the small central spot appears jet black and the large surrounding area is pearl white in tint. The same motion persists." The appearance of the vertical lines at this time was so extraordinary that they are here reproduced in No. 19. At this visit it was found that vision in the right eye had tripled -fa whilst that of the left eye equalled full -f. Although there were some evidences of iodism, I continued the drug just as before. On the following day (22d of June) the spot appeared as if split into two sections and the bright area had gone (No. 20). The patient's notes state: "I cannot draw the shape of the spots unless I close the eye rapidly. They are in constant motion, like the one shown in drawing No. 3." IV. Right eye. CASE OF CHORIO-RETINITIS IN THE MACULAR REGIONS. 7 The vertical lines had undergone a marked change. They were not so broken, and the heavy, dense, horizontal thickenings were replaced by six broad, faint horizontal smudges. The right fundus in the macular region seemed to have regained its natural tint, though careful focussing revealed the presence of a few faint and almost imperceptible, deeply-seated pigment splotchings and aggrega- tions. On the 24th of June a most curious parsesthetic area, represented in No. 21, appeared. Of this the patient wrote, "This shape stayed only for about one hour, fading to the shape shown in drawing No. 18. It has the appearance of waves of light composed of fixed radii which pass out- wardly from the centre. These waves elevate and depress themselves from the centre just the same as if one threw a stone into the water,-the waves flowing from where the stone struck the water; so here the spot is similar to the waves, except that being water they are waves of light. Central vision with the right eye equalled eccentrically it rose to r On the 29th of June the sketch shown in No. 22 was made. The fig- ure is that of a roan smoking a cigar and carrying a cane as he was leaving the patient. " The white area represents the man as he appeared with the right eye while I was looking at the middle of his back. The surround- ing shaded area shows him as I know what he should be." Central vision directly ahead with the left eye equalled one-half of normal (T I did not see the patient again until the 2d of July. He said that he had taken the tri-daily dose of twenty grains of iodide of potassium faith- fully and had not attempted to use his eyes in any way, being careful to wear his smoked glasses constantly. At this visit he drew the sketch represented in Nos. 23 and 24. The scotomata had become fixed and all objects appeared "'very small." His comments as to the sketch are as follows: " Now you can see a great differ- ence in the two areas in regard to shape and size and the dense dark spots over them. No. 23 has eight small black spots; No. 24 has eight also, but they cut across the whole area from left to right as a series of stripes. When these bands or stripes first appeared it seemed to me that the spots actually lengthened themselves out to become stripes." Four days later I had him make a sketch of my card of test-type which was hanging on the wall at about two metres' distance. The result is shown in No. 25. The noting at the side of the drawing read : " This shows the appearance of Dr. Oliver's card while I am looking at the letter ' O' in the upper right-hand corner." On the 8th of July he came back very much disturbed, saying that, although the size of the general area was diminished and the dense super- imposed spots reduced to five, yet these were in such a state of constant motion, just as they had been in No. 3, as to be annoying. The appearance of the fixed and superimposed mobile scotomata is shown in Fig. 26. 8 CHARLES A. OLIVER, M.D. He voluntarily stated that during heavy thunder-storms, where there is much lightning, he gets demoralized and " must get into a dark room so as to prevent the right eyeball from jerking and twisting in its socket." The next day, to his gratification, the five spots disappeared, but the gray area upon which they had seemed to rest had grown somewhat larger. No. 27 shows this very well. On account of pronounced iodism I stopped the iodide, ordering him full doses of strychnine instead. I missed him for another wTeek, when he came back with the assertion that he had ignored the strychnine and had unremittingly continued his tri- daily dose of twenty grains of iodide of potassium. In spite of the marked iodism I persisted in the use of the drug. The bright mobile spots had once more come to trouble him. The morning of his visit he had the appearance shown in No. 28. He said that while sketching the scotomatous boundary " several bright spots shot in towards the centre from the outer edge like roman candles; in fact, they resembled them very much. After striking the centre they dis- appeared. This phenomenon lasted for about one minute." Some hours after this he accidentally found that, while gazing down upon a white marble floor and drawing the scotomatous area, two eccentri- cally situated and fixed bright areas of light, just as "when the sun shines through the slat-work of a shutter," were projected upon the floor. The position of these light areas and the central scotomatous area are shown in No. 29. Notwithstanding the scotoma, the eccentric vision up and in in the right eye had increased to about two-thirds of normal (A). On the succeeding second and third days the central dim area which stayed fixed became larger. The eccentric light areas, first noticed on the 16th of the month, remained equally bright, but had become a trifle smaller. At the upper border of the large dim area a brilliant and serrated worm- like mass kept in constant motion. This can be seen in No. 30. " During the afternoon of the third day the two bright spots in the lower right-hand corner disappeared," and immediately the dense black strokes shown in No. 31 came on, they first being " lightish" and gradually becoming "darker." By the 18th of the month the four faint scotomatous areas before the left eye had practically gone. I found, however, by refer- ence to his notes, these words: " While lying in bed on the night of this date, and being unable to sleep and very restless, I looked up at the moon, when slightly down and out from it there were two somewhat luminous objects in the sky. These were stretched out vertically, quite close to each other, and moved around the moon as I moved my head in the same direc- tion." One week later the spot before the left eye again came into evidence. At this time all objects immediately below the fixation point were obscured. A drawing of a man's face in profile made while he was looking at the V. Left eye. Fig. 1. Ophthalmoscopic appearance of right eye-ground. Fig. 2. Ophthalmoscopic appearance of left eye-ground. CASE OF CHORIO-RETINITIS IN THE MACULAR REGIONS. 9 top of the model's nose placed the mouth and chin in the scotomatous area. Fig. D, showing the appearance of my card of distant test-type when the patient was looking at " E" " O" on the top line, will explain very well what is meant. On the 30th of the month he told me that the objects seen through the comparatively clear areas were much larger and more nearly what they should be than before. The notes of the 5th of September state that he was taking eighty grains of iodide of potassium daily with impunity, he having a good appe- tite. Nothing noteworthy was apparent until this date, when a minute, fresh hemorrhage, with its convexity directed upward, could be seen just below the left fovea, between the retina and the chorioid. The macular region of the right retina was faintly granular and slightly pigmented. He stated that the left eye had become painful during the previous night, and when he had gotten up and lit the gas he found that there was a dense black spot in the centre of its field of vision. On the 10th of September he found that the left scotoma had become reduced, in his own words, " to a lot of faint spots, which, as near as I can explain, look like drops of water slowly flowing down a pane of glass, one trying to beat the other." On the same day, without warning, a dim representation of No. 21, seen on the 24th of June, appeared before the right eye, and lasted for about twenty-four hours. On the following morning he noticed that the large, dim scotoma before the right eye, which has been so persistent and fixed during the summer months, recurred ; but, curiously, its edges seemed broken away, and lost. Through this area, and in no other position in the field of fixation, was there any complaint of micropsia. The scotoma gradually became faintly mottled, and at last decreased in density, until a drawing made on the 9th of October showed that the area was barely discernible. At this visit he brought sketch of Fig. E, which, as he said, showed " the shape, size, and shade of the spots in the left eye. There is no motion whatever." After a most rigorous examination no cardiac or renal lesion could be determined. Vision in the right eye had risen to one-half of normal, while that in the left eye was normal. When the patient regarded any object fixedly with the left eye the image of the object became alternately larger and smaller, and seemed distorted upon its edges, just "as though it were viewed through a convex lens which is successively elevated and de- pressed." The subretinal hemorrhage in the left eye was beginning to manifest evidences of beginning absorption. Two weeks later the ophthalmoscope showed that there were a few faint pigment-spots in the right retina, and that the minute hemorrhage in the left subretinal tissue was nearly gone, the retina in the macular region being elevated and depressed into several almost imperceptible striae. The 10 CHARLES A. OLIVER, M.D. patient stated that he had not used any alterative for more than a week. He was told to discontinue its use. On the 17th of October he returned with the statement that the day before he had attempted to resume his work, but found that he was com- pelled to desist on account of the annoying distortion and dimness of objects. A most careful correction of his minor degree of astigmatism, obtained both with and without the employment of a mydriatic, failed to relieve the condition in any way. During the month of November he returned several times. On the 26th of the month he made some sketches showing the contracting effects upon long, narrow, rectangular forms placed at different angles in the scotomatous areas. These, which were most numerous and ingenious, will be reserved for another paper upon a related subject. In January, 1895, the scotoma in the right eye could be just seen. He wrote, "Vertical lines are not broken or drawn together, and objects seem very little distorted." The accompanying reproductions of two faith- ful water-color sketches (Figs. 1 and 2) by Miss Margaretta Washington, of this city, were secured about this time. The relative conditions seen are so self-evident that written description is rendered unnecessary. The iodide of potassium was persistently continued, as much as possible, attacks of iodism, coming on very quickly and persistently, requiring constant counter-medication. Once in February he returned with a slight, though temporary, increase in dimness in the right scotoma. At this visit he told me that the left one " had preserved the same shape and shade, but that the smaller spots were plainer (darker) and seemed to be increased in number." His statement that at times there was some supraorbital neuralgia, and that frequently there was an irregular and vibrating mesh-work thrown between the left eye and the object looked at, induced me to make a most careful, though fruitless, examination of the media and muscular apparatus of the organ. Central vision with the right eye had steadily risen to one- fourth of normal (/q-), while that of the left eye was practically normal. The dose of iodide of potassium, which had been taken with mon or less regularity, was reduced to five grains three times daily. On March 27 of last year, in order that I should better realize the rela- tive difference between the two sights, he gave me two rough sketches of the same object studied from the same objective point, nearly four blocks away (the statue of William Penn upon the City Hall in Philadelphia). When study is made of these, which are reproduced in the full-page photo- type (Plate VI.), it will be instantly noticed that (with the same minor degree of refractive error) the image of the right eye is much the smaller, thus substantiating in another and most graphic way his constantly-repeated assertions of micropsia. The projections of the faint scotomatous areas against the head and back of the figure and the larger size of the left scotoma are all most interesting and instructive. VT. CASE OF CHORIO-RETINITIS IN THE MACULAR REGIONS. 11 In September, 1895, he returned for the removal of some dirt that had blown into his left conjunctival cul-de-sac. At that visit I embraced the opportunity of restudying his case. His vision, which was central in each eye, had risen to two-thirds of normal in the right eye and to full acuity in the left. Accommodative power and play were equally good in each eye. He considered his right eye well. At times water-like globules would appear in the centre of the left field of vision. Careful focussing with the ophthalmoscope revealed the faintest traces of the macular changes shown in Miss Washington's sketches. An extended re-examination the beginning of this month (July, 1896) gave practically the same findings as were noted ten months previously. A final series of characteristic sketches of geometrical forms, in which the distance between any two parallel lines (especially the horizontal ones) was made very small, showed minor degrees of bulging just at the fixation- point with the right eye, and rather more marked elevation and depression of the entire widths between the two lines away from the fixation-point with the left eye. He is now unable to project any scotoma, "any mark, blur, or spot" with the right eye, " except by looking up at a clear sky, and then only a very faint outline of the old spot appeared." With the left eye he can project a few extremely attenuated and almost invisible grayish scotomata around and especially above the macular region, these in the carefully taken corresponding field of vision being evidenced by the faintest dim areas for color and form. The field of vision of the right eye fails to show any scotomata, but in a small area about three de- grees above the fixation-point extremely minute and circular test objects appear elongated into a vertical oval The fields of vision, which were frequently repeated during these studies, at no time evidenced any contraction in the peripheral boundaries, the central scotomata, which were constantly absolute for color and at times negative for form, always agreeing with those that the patient made in the sketches from which the figures were taken. Remarks.-The present case is here given in its minutest details in order that an almost unique instance of intelligent subjective study, in com- bination with a fairly well-made series of clinical researches and an exact graphic reproduction of the intraocular lesion found, might be made use of by others in their studies upon such comparatively rare and quickly evanescent symptom-groupings. Uncomplicated, having been seen but a few minutes before the accident, studied carefully, and watched almost incessantly, the case assumes a certainty that entitles it to consideration. Although the literature upon the subject has been well searched over, and much that has been done by others has not been attempted here, yet with this latter shortcoming, this clinical study is given to the ophthalmic world in the hope that it may be not altogether fruitless and useless. 12 CASE OF CHORIO-RETINITIS IN THE MACULAR REGIONS. The writer here desires to express his obligation to the patient himself for his untiring aid and conscientious study of the constantly varying symptoms, without which help much of the interest and value of the paper would have been lost. To the writer's several clinical assistants, especially to Dr. William Campbell Posey, his official assistant at the hospital, much credit must be given for their skilful and careful clinical handling of the case. 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