PNEUMONIA IN BOSTON DURING THE RECENT EPIDEMIC OF INFLUENZA. BY George B. Shattuck, M.D., Visiting Physician to the Boston City Hospital. 'Reprinted from the Boston Medical and Surgical Journal of May 26, i8()2. BOSTON: DAMRELL & UPHAM, PUBLISHERS, 283 Washington Street. 1892. S. J. PARKHILL & CO., PRINTERS BOSTON PNEUMONIA IN BOSTON DURING THE RE- CENT EPIDEMIC OF INFLUENZA.1 BY GEORGE B. SHATTUCK, M.D., Visiting Physician, Boston City Hospital. During the progress of the epidemic of influenza, with which, I think, we must acknowledge we have been visited this winter, I was impressed with the evident increase in the number of cases of pneumonia entering the City Hospital in my own service and in those of my colleagues, and also with the large number of deaths, especially among old people, as appearing in the daily papers and in the reports of the City Board of Health. Moreover, not a few of the pneumonias, as observed at the City Hospital, exhibited peculiari- ties or irregularities ; they w'ere less frank than usual in their development and in their resolution. As I had about this time fallen a victim to your President’s energy, and promised to occupy part of one of his evenings, it occurred to me I would look up these general points in a general way and give you the results, which might at least derive some interest and possibly some value from a comparison with those of a very recent previous epidemic of influenza, and those of an intervening non-epidemic year, sandwiched be tween the two. But upon re-reading the contributions to the expo- sition of the relations between pneumonia and influenza and the mortality-rate and influenza, I found them more elaborate than I had remembered them to be. I thought, however, it was desirable that any new statements in regard to the past two years should be 1 Head at the meeting of the Boston Society for MedicalJjj+pjtrye- ment, 2 put in a form comparable with those previously fur- nished with regard to the previous epidemic. Hence, instead of letting you off with a few simple, and per- haps vague statements, I come before you with some tables, a form of setting forth facts which it has been my duty as an editor to discourage in others. The immediate cause of this unfortunate result is the zeal of your President, as before said; the remote cause is the zeal of my predecessors. The Clinical Section of the Suffolk District Medical Society held a meeting January 15, 1890, for the dis- cussion of influenza then epidemic in Boston, a discus- sion which was opened by Dr. F. C. Shattuck and closed bv Dr. A. L. Mason ;2 at this meeting the relation of pneumonia to influenza was incidentally considered. The New York Academy of Medicine devoted its meeting April 7, 1890, to the discussion of the relation of pneumonia simply to influenza. Dr. E. G. Janeway occupied himself with New York, but his paper was not published ; Dr. Wm. Pepper gave the results for Philadelphia; 8 and Dr. F. C. Shattuck those for Boston.4 As our subject was not only the same hut dealt with the same locality, it seemed better to follow tbe gen- eral plan of dealing with it adopted by my brother two years ago, and see how far the results would lead to similar conclusions reached by him then or formulated by Dr. Pepper from his figures and observations ob- tained in Philadelphia. Accordingly where there were tables — and I regret both for your sake and my own that there were so many — I have tabulated the same details for 1890-91, 1891-92, thus giving a compari- son of eight years instead of six, and of two epidemic 2 Boston Medical and Surgical Journal, vol. cxxii, No. 7,1890. 8 Remarks on the Frequency and Character of the Pneumonias of 1890 ; Medical News, vol. lvii. p. 1, 1890. 4 The Relation of Pneumonia to Influenza in Boston: New York Medical Journal, vol. li, p. 650, 1890. 3 periods instead of one, For, whether or not there was a recurrence of influenza as an epidemic at any earlier period of the year 1891 than December, I think we may accept the months of December, 1890, and Janu- ary, 1891, as practically free from it. I have tabulated the records of the Boston City and of the Massachusetts General Hospitals, from December 10, 1890, to Feb- ruary 1, 1891, and from December 10, 1891, to Feb- ruary l, 1892, as a continuation of similar statistics for previous years. As arbitrary dates have to be adopted to represent the epidemic limits, these are, perhaps, as good as any others. It may be that some observers would fix an earlier or a later date for the beginning or the decline of this or of the previous epidemic, but for purposes of comparison, especially in regard to diseases of the respiratory organs, it is, of course, essential to take as nearly as possible the same season of each year. Deaths from Pneumonia reported at the Boston City Hall for the Months of December and January, 1884-85 to 1891-92, inclusive. Table I. Months. 1884-85 1885-80 1880-87 1887-88 1888-89 1889-90 1890-91 1891-92 Decemb’r 141 74 113 95 68 105 100 223 January, 103 83 91 183 92 332 139 240 Total, 244 157 204 278 160 437 239 463 Table I shows that the number of deaths returned in Boston as due to pneumonia, December and Janu- ary, 1891-92, was greatly increased over the previous six non-influenza years; that this increase was about as great for December as for January ; that the num- ber of deaths for the two months exceeded that of 1889-90, by 26, though the distribution was different, 4 there being 118 more deaths in December, 1891, and 92 less deaths in January, 1892. Table II. Cases of Pneumonia admitted to the Poston City and Massachusetts General Hospitals from December 10th to February 1st, for the Years 1884-85 to 1891-92. 1884-85 1885-86 1886-87 oc 00 oo 00 1888-89 1889-90 1890-91 1891-92 Total, 33 26 80 68 40 127 48 101 Deaths, 14 4 12 26 13 38 13 39 Mortality 42+% 15+% 40% 39% 32J% 30% 27% 38% Table II shows, from the hospital returns, that the mortality, as well as the number of cases, was largely increased, the per cent, being above the average of the previous six non-influenza years, whereas it was 2below the average of those years for the same period 1889-90. It is a curious coincidence that twenty-six fewer cases of pneumonia entered the hos- pitals, and twenty-six more deaths were reported at City Hall. Table III shows by weeks that the increase in deaths from pneumonia began earlier and was more rapid this winter than last winter or the winter of the previous epidemic, and the same is true of bron- chitis comparing this winter with last. The week ending January 2d, was the week of greatest mortal- ity from pneumonia this winter, whereas last winter and the winter before it was a week later. The max- imum mortality from bronchitis occurred the same week this winter as last winter, and the number of deaths was, curiously, the same ; it was a week later than that for pneumonia. If the early increase in deaths from pneumonia was dependent upon epidemic 5 influenza the epidemic this season should have mani- fested itself earlier than two years ago. Personally I Table III. Deaths from Pneumonia reported at the Poston Board of Health in December and January, 1889,1890, 1*91 and 1892, by Weeks. Deaths from Bronchitis December, 1*90, 1891, January, 1891, 1892. Date. Bronchitis. Pneumonia. Date. | Bronchitis. Pneumonia. Date. Bronchitis. Pneumonia. 1889. 1890. 1891. Week eDding Week ending Week ending Dec. 7, 9 Dec. 6, 11 11 Dec. 5, 14 26 “ 14, 13 “ 13, 11 26 “ 12, 14 41 “ 21, 17 “ 20, 11 22 “ 19, 15 31 “ 28, 36 “ 27, 10 24 “ 26, 27 57 1890. 1891. 1892. Week ending Week ending Week ending dan. 4, 89 Jan. 3, 16 27 Jan. 2, 30 85 “ 11, 117 “ 10, 10 38 “ 9, 38 79 “ 18, 93 “ 17, 12 31 “ 16, 31 74 “ 25, 38 “ 24, 6 25 “ 23, 24 55 “ 31, 18 29 “ 30, 16 39 Table III bis. Total Tabulated Cases of Pneumonia at the Boston City Hospital and Massachusetts General Hospital. City Hospital. Mass. Hosp. Total. Dec. 10, 1890, to Feb. 1, 1891 , , . 36 14 50 Deaths 4 13 Mortality . . 25% 28+% 26% Dec. 10,1891, to Feb. 1, 1892 . . . 87 20 107 Deaths 6 40 Mortality ■ . 39%% 30% 37% should have said it developed, if anything, a little later. The editorial column of the Boston Medical 6 and Surgical Journal, probably upon good author- ity, under date of December 17, 1891, says: “It seems to be the general impression that epidemic in- fluenza has once more made its appearance in the United States, though as yet it has not assumed a serious aspect. The Boston Board of Health does not officially recognize its presence in this city, but admits the apparent increase of catarrhal troubles and pneumonia during the last month,” etc. The views of individual practitioners upon this point would be of value. Looking from another point of view at the returns to the city authorities of the deaths from pneumonia and bronchitis, I find the following: the average of deaths from pneumonia for the month of December in the five years 1884-88, was 104; in December, 1889, the deaths were 160; in December, 1890, 100; and in December, 1891, 223: the average for the five Januarys, 1885-89, was 118.6; in January, 1890, the number was 353; in January, 1891, it was 139; and in January, 1892, 240. In the same way for bronchitis, the average of five Decembers was 54.8; the number for December, 1889, was only 43; for December, 1890, 49; and for December, 1891, 90. For the five Januarys the average was 53.2; for January, 1890, the number was 89 ; for January, 1891, 48 ; and for January, 1892,109. Before tabulating the total cases of pneumonia (meaning thereby croupous pneumonia) entered at the two hospitals between December 10 and February 1, 1890-91, 1891-92, I was curious to see the pro- portion of cases in each. I got the following result shown in Table III bis. which includes both croupous and catarrhal or broncho-pneumonias — the number of the latter being small — ten in all for the two years, at both hospitals. The great increase in the number of cases, as well 7 as in the number and percentage of deaths this win- ter, comes largely, therefore, from the City Hospital ; and there also the proportion of males was larger — sixty-five males to thirty-two females, while at the Massachusetts there were twelve males to eight females. Table IV. Analysis of all Cases of Lobar Pneumonia admitted to the Boston City and Massachusetts General Hospitals, from Dec. 10, 1889, to Feb. 1, 1890, with Reference to the Precedence of Grippe Symptoms, Localiza- tion, Complications, and Termination — Lysis or Crisis, or Death. Preceded by grippe ! symptoms Not preceded by grippe symptoms. Doubtful. No history. Total, Total, number 55 36 26 10 127 “ per cent 43 29 20 8 100 Single "lobe, number 39 17 14 6 76 “ “ per cent 71 47 54 60 60 Unilateral, more than ( number . 6 11 5 4 26 one lobe . . . . ( per cent. 11 31 19 40 20 Double, number 10 8 7 25 “ per cent 18 22 27 20 Complicated, number .... 13 11 14 5 43 “ per cent 24 31 53 50 34 Recovery by crisis, number . . 15 7 3 25 “ “ per cent. . . 44 44 21 36 Recovery by lysis, number. . . 19 9 11 5 44 “ per cent. . . 56 56 79 100 64 Death, number 11 14 8 5 38 “ per cent 20 39 30 50 30 December 10, 1891, to February 1, 1892. Total, number 28 61 1 11 101 “ per cent 27 60 1 11 100 Single lobe, number 22 48 1 9 80 “ “ per cent 80 80 100 80 80 Unilateral, more than ( number . 2 8 1 11 one lobe . . . . | per cent. 7 12 10 10 Double, number 4 5 1 10 “ per cent 14 8 10 10 Complicated, number .... 6 20 6 32 “ per cent 21 33 50 33 Death, number 11 21 i 6 39 “ per cent 40 34 100 50 38 8 Table IV gives an analysis of the cases of pneu- monia in the two hospitals — the extent of the pro- cess, the complications and the mortality — with refer- ence to influenza antecedents as gathered from the records. I have not attempted to include recoveries by crisis and lysis, partly because the dividing line is very un- certain, and partly because the charts in many cases had not been entered and were not easily accessible. The results of this analysis differ materially in several important particulars — and especially as to the per- centage of pneumonias preceded by influenza-symp- toms— from those of a similar analysis of hospital cases in the previous epidemic published in Dr. F. C. Shattuck’s paper. The difference is probably due more to a dilference of record-keeping or record-interpretation than to so great an actual difference iu facts. Of the total pneumonias only 27 per cent, are recorded as pre- ceded by influenza; 60 per cent, were not entered as preceded by such symptoms, and one per cent, doubt- ful. This compares with 43 per cent, preceded by such symptoms in the previous epidemic, and only 49 per cent, not preceded or doubtful. The percentage of complications was about the same for the two epidemics, and the only other marked difference appears in the mortality which has already been alluded to. Table V gives the age and sex of the 101 hospital cases. The percentage of males was rather less than in the previous epidemic, 70—f-% compared to 74-f-%, and of females 30% compared to 26%. There were no deaths under twenty years of age, and only five cases, all of which were in males. The mortality in- creased pretty constantly in the next three periods of twenty years. 9 Lobar Pneumonia in Boston City Hospital and Massachusetts General Hospital, December 10,1889, to January 31, 1890. Table V. Age. Oases. Male. Female. Fatal. 10 and under 2 2 0 0 10 to 20 14 9 5 2(14%+) 20 to 30 41 28 13 T (17%+) 30 to 10 31 25 6 10 (32% +) 10 to 50 16 12 4 8 (50%) 50 to 60 13 9 4 7(51%-) 60 to 70 1 1 0 1 70 to 80 1 0 1 0 Unknown 8 8 0 3 Total 127 94 (74%) 33 (26%) 38 (30%) December 10,1891, to February 1, lt-92. 10 and under 1 1 0 0 10 to 20 5 5 0 0 20 to 40 53 36 17 18 (34%) 40 to 60 23 17 6 9 (39% +) 60 . 9 5 4 5 (55 J%) Unknown 9 7 3 7 (s0% -) Total 101 71 30 39 (38% +) The upper half of this table shows the age and sex of 127 hospital cases. Nearly 75% were males, and the mortality increased with each decade up to the fifth, remaining stationary thence to the seventh. Table VI analyzes the deaths from pneumonia and broncho-pneumonia, as reported to the city authorities, with reference to age, and compares the deaths in De- cember and January, 1891-92, with the same months in 1889-90, and the average of the previous five years. There was an increase in deaths over the average deaths in December for every decade except one (10- 20) up to 100, this increase culminating in the decade between 80 and 90 with 479 per cent. In December, 1889, there was no increase under twenty or over seventy, at other ages there was a marked increase 10 over the average, hut a less increase for every decade except two, 20-30 and 40-50, than in December, 1691. Fatal Pneumonia and Broncho-pneumonia reported at the Boston City Hall. Comparison between December, lss9, and January, 1S90, and the average of the same months during the previous five years, with reference to age. Table VI. Age. Avge. deaths, Dec., 1884-8. Deaths, Dec., 1889. Per ct. of in- crease. Avge. deaths, Jan., 1885-9. Deaths, Jan., 1890. Per ct. of in- crease. 10 and under . . 36.2 37 36 56 55 10 to 20 .... 2.6 3 1 14 250 20 to 30 .... 8 26 225 8.8 43 388 30 to 40 .... 10 22 120 17 54 218 10 to r>o .... 11.8 28 137 15 0 57 265 50 to 00 .... 11.4 18 58 11 8 50 324 00 to 70 .... 11.2 15 34 1£ 38 192 70 to ro .... 9 8 10.2 28 175 80 to 90 .... 3.8 3 2.2 13 500 Comparison between December, 1891, and January, 1892. Deaths, Per cent. Deaths, Per cent. Age. Dec., of in- Jan., of in- 1891. crease. 1892. crease. 10 and under . . . 60 65 44 22 10 to 20 2 0 20 to 30 13 624 22 150 30 to 40 23 13C 29 71 40 to 50 22 86 32 105 50 to 00 21 81 26 120 GO to 7 0 32 186 41 215 70 to so 28 211 31 204 80 to 90 22 479 14 530 90 to 100 1 1 In January, 1892, there was a large increase over the average for every decade except one, 10-20— when there were no deaths—culminating in an in- crease of 536 per cent, in the decade 80-90, which compares with 500 per cent, increase for the same 11 decade January, 1890; for the earlier decades the in- crease was smaller for January, 1892, than for Janu- ary, 1890, but it was larger for the very old, that is the three decades 60-70, 70-80, and 80-90. Fatal Bronchitis reported at the Boston City Hall. Comparison be- tween December, 1889, and January, 1890, and the average of the same months during the five previous years, with reference to age. Table VII. Age. Average deaths, Dec., 1884-8. Deaths, Dec., 1889. Average deaths, Jan., 1885-9. Deaths, Jan., 1890. Per cent, of in- crease. 10 and under . . 37.2 23 36.8 29 10 to 20 . . . . 0.0 1 0.4 3 650 20 to 30 . . . . 0.2 2 900 30 to 40 . . . . i 3 1.4 3 114 40 to 50 . . . . 1.4 1.4 5 256 50 to 60 . . . . 4.8 4 2.4 8 233 60 to 70 ... . 6 5 3.4 13 282 70 to 80 . . . . 2.4 4 5 13 160 80 to 90 . . . . 1.4 3 2.6 13 400 Comparison between December, 1891, and January, 1892. Deaths, Per cent. Deaths, Per cent. Age. Dec., of in- Jan., of in- 1891. crease. 1892. crease. 10 and under . . 42 13 0 10 to 20 . . . . 1 83 0 20 to 30 . . . . 2 3 1,406 30 to 40 . . . . 1 0 G 329 40 to 50 . . . . 0 329 4 186 50 to GO . . . . 9 87£ 9 275 60 to 70 . . . . 12 ioo 13 282 70 to 80 . . . . 15 525 17 240 80 to 90 . . . . 3 114 14 438 90 to 100. . . . 1 The very small number of deaths from pneumonia and bronchitis between the ages of 10 and 20 years in the city returns for any year is very striking. The city returns, it may be remarked incidentally, 12 show five deaths from bronchitis and pneumonia be- tween the awes of ninety and one hundred in Decem- ber. 1890-91, and January, 1891-92. Table VIT analyses bronchitis reported to the city, as Table VI did pneumonia, with reference to age. Deaths from bronchitis in December under ten years were increased slightly, in January there were none under twenty years ; in December and January, 1889, 1890. under ten years they were less than the average, for all the other decades, except one, for both months there was irregular but considerable increase. The numbers, however, in all three years were too small to be of much value. Having compared my figures for the present epi- demic and the one free year with those published in my brother’s paper for the previous epidemic and for the five free years, we will see how the conclusions to which my figures lead, compare with those to which his figures lead him. He says : “Conclusions can be drawn, but they do not seem to me of such a nature as to throw any really new light on influenza pneumonia.” With this state- ment I fear I must agree. The conclusions are as follows: “ (1) Pneumonia was unusually prevalent in Boston during the height of the influenza epidemic, about the middle third of the visitation.” My figures indicate that it was unusually prevalent this winter, too, but reached its culmination a week earlier. “ (2) The statistics of the Pacific Mills indicate that less than a half per cent, of those severely attacked bv influenza acquired pneumonia. “ (3) Broncho-pneumonia was rare in the hospitals.” I find onlv six cases in both hospitals this winter. “ (4) The pneumonia mortality rate was probably not increased, perhaps diminished, as compared with that of the five previous years.” For this epidemic it 13 was increased eight per cent, over the previous epi- demic and five and one-half per cent, as compared with the average of six free years. “ (5) The number of cases of pneumonia not pre- ceded by grippe symptoms was about the same as the number of pneumonias in an average year.” The number was apparently greater than thfe number in an average year. “ (6) Pneumonia followed grippe in so large a num- ber of cases as to show some sort of connection be- tween the affections.” In a sufficiently large number of cases. “ (7) In sixty per cent, of the cases a single lobe only was involved.” In eighty per cent. “ (8) Two-thirds of the cases terminated by lysis.” “ (9) Pneumonia was three times as frequent in males as in females, and the mortality rate increased with each decade.” Two and one-third times. “ (10) The most striking increase in the urban deaths from pneumonia was, on the whole, between the ages of twenty and sixty and eighty and ninety. The increase under ten was slight.” The increase in the urban deaths from pneumonia was greatest be- tween the ages of sixty and ninety ; it was striking, but evenly distributed between twenty and sixty ; under twenty it was slight. “(11) The gross appearances in nine cases exam- ined after death were not specially noteworthy.” Autopsies not considered. Dr. Pepper's estimate from returns made to him by a large number (272) of practitiouers in Philadelphia, of the relative proportion of croupous and catarrhal pneumonias, differs greatly from the results afforded by our hospitals. These returns indicate that the catarrhal were almost twice as frequent as the croupous. He further states that Dr. DaCosta and he saw about an equal number of catarrhal and croupous pneumonias 14 in consultation. He notes as a peculiarity of the pneu- monias during the epidemic season 1889-90 the large preponderance of cases affecting the right lung, which he estimates was affected twice as often as the left. Of 101 hospital cases in Boston from December 10th to February 1st, this winter, the right lung alone was affected in the left alone in 32-)-% ; but I find that of 44 cases for the same period last winter, when there was no epidemic of influenza, in 53% the right alone was affected, the left alone in 33%. Osier re- ports that in 100 pneumonia autopsies at the Montreal General Hospital, not made during an influenza epi- demic, the right lung was affected in 51%, the left in 32% and both iu 17%. Of last winter’s hospital cases in Boston 14% were double, aud this winter’s only 10%. Apex Broncho-pneumonia, Whole of one lung . Double Left lung alone . . Right lung alone . . Amount of Lung in- volved and region affected. • 4- © to © tn to © Total Cases. e M a> (l? • to • 05 4- to © tn © Per cent. to CO Of Apex. * © O © to Or 4* © Delirium ■_ £ on to to © to Alcoholic Habits. C£> © o m - to 4» © Mortality. • c+ o 05 QC £ © © © Or © Total Cases. a : © W to MH Ox Per cent. © ? O' © to © Apex. O oi © 4* © Delirium. *-* 00 2° s © 05 to to Or £ Alcoholic Habits. to- to © -q © © to © Mortality. o '28 10 to © 4- © © Total Cases. H to at to Apex. © t-1 00 © © © Delirium. p J_k £ 4- © to © Alcoholic Habits. o tO 4* 00 © 4* It © Mortality. p* Table YIII. Dec. 10, 1890, to Feb. 1, 1891, 44 cases'. Dec. 10,1891, to Feb. 1, 1892, 101 cases. Both jears, 147 cases, including two of doubtful location. 15 Though not coming strictly under my subject, curios- ity and a desire to make use ot' my figures led me to look into the question of apex pneumonia,— especially as I have for some time been sceptical of the current statement that it is more apt to be accompanied by delirium. In 18 apex pneumonias (T7% of the total) of the influenza period, there were 9 deaths, or 50% ; but 6, or 33%, were of markedly alcoholic habits, and only 5, or 28%, exhibited delirium. One case, notwithstanding the apex and the alcohol, was not delirious and got well. One case of double apex died two days after entering the hospital, this is not included. Last winter in 10 apex cases (23% of the total), five died, five had alcoholic habits, and six were delirious; that is, one only was delirious without beino; alcoholic. Jn regard to his returns for the 1889-90 epidemic. Pepper says : “ There was also an unusual proportion of cases of apex pneumonia where the entire upper lobe was completely consolidated without implication of any other part. As usual in such cases, there seemed to be a special predominance of cerebral symptoms.” Among the complications were inflammations of the ear of various degrees of severity, erysipelas, rheuma- tism, tuberculosis, empyema, cardiac lesions and peri- carditis, melancholia, acute mania, meningitis, alcohol- ism, cerebral embolism, erythema, etc. One young woman entered my service at the City Hospital with undoubted influenza. She developed an erythema of the face, then a pneumonia; she then miscarried at the fifth month; she then developed diphtheria; and she subsequently recovered her health perfectly. I had intended to sav something about the vague symptoms and ill-defined physical signs observed in some cases of so-called pneumonia during the influenza, but I have already taken up too much of your time. I hope some of you will favor us with your personal 16 experiences as practitioners; some T know have seen comparatively little pneumonia this winter and others more than usual. To sum up briefly, I should incline to the opinion that true pneumonia was a sequel rather than a concomitant or complication of influenza. Though I acknowledge that the tables presented do not offer alone sufficient support for this view. Pepper takes this position in the following words : “ The vast majority of pneumonias occurred as a sequel, rather than a complication, and they were clearly trace- able to exposure to damp and raw weather while the patient had a relaxed system and while slight pyrexia persisted after the subsidence of the more marked symptoms of his influenza. Experience furnishes many instances of this fact.” Osier, in his “ Practice of Medicine,” just published, speaks of pueumonia as a complication, and the most serious and fatal one of influenza; but at the same time states that there is, as far as his observation goes, nothing special or peculiar in the character of the pneumonia. Through the courtesy of Drs. Mason and Folsom at the City Hospital and of Drs. F. C. Shattuck and W. W. Gannett at the Massachusetts General Hospital, I have had access to their cases; and I have to thank Dr. A. C. Jelly and my house-officers, Drs. Dudley and Towle and Mr. Edson, for assistance in abstract- ing the records, and the Boston Board of Health for figures furnished. My use of Dr. F. C. Shattuck’s tables speaks for itself. As they were originally pub- lished elsewhere, their reproduction here commends itself additionally. Two Volumes yearly, beginning' with the first Nos. in January and July. But Subscriptions may begin at any time. This Journal has been published for more than sixty years as a weekly journal under its present title. Still it is incumbent upon th’s Journal, no less than upon others to assure its patrons from time to time, as the occasion arises, of iis desire, ability, and determination 10 meet all the requirements or the most activ ■ medicai journalism ot the day, without sacrificing any of that enviable reputation which is an inheri- tance irom the past. It is under the editorial Management of Dr. George B. Shattuck, assisted by a large staff of competent coadjutors. Communications from all quarters of the country are acceptable. Liberal arrangements are made for reprints of original articles, and for such illustrations as serve to increase their value or interest. All editorial communications, and books f >r review, should be addressed to the Editor. Subscriptions and advertisements received by the undersigned, to whom remittances should be sent by money-order, draft, or registered letter. Terms of Subscription : In the United States, and to Canada and Mexico, $5.00 a year in advance. To Foreign Countries embraced in the Universal Postal Union, $1.56 a year additional. Single numbers, 15c. Ten consecutive numbers free by mail on receipt of $1.0U. Sample copies sent free on application. THE BOSTON MedicalandSurgical Journal. A FIRST-CLASS WEEKLY MEDICAL NEWSPAPER. PUBLISHED EVERY THURSDAY. Published by DAMRELL & UPHAM, £283 Washington. St., Boston.