Concerning the Employment of Light in the Treatment of Disease. A PAPER READ BEFORE THE NASHVILLE ACADEMY OF MEDICINE, AUGUST 4, 1892. By Will F. Arnold, M. D., Passed Assistant Surgeon oj the United States Navy. NASHVILLE, TENN.: Brandon Printing Company. 1892. [Reprint from the Southern Practitioner, September, 1892]. CONCERNING THE EMPLOYMENT OF LIGHT IN THE TREATMENT OF DISEASE.* BY WILL F. ARNOLD, M.D., Passed Assistant Surgeon, United States Navy. Mr. President and Gentlemen of the Academy: I believe that there is nowhere a well-known published account of the employment of a burning-glass (or of a reading-glass) for a therapeutical purpose; and this, upon reflection, will appear none the less strange when we consider the whilom popularity of counter irritation, and ob- serve that the efficiency of concentrated sunlight as an agent for immediate vesication, entitles it to rank with stronger water of ammonia and with Corrigan's button-cautery, otherwise called the thermal hammer. In December, 1890, I observed a physician in San Francisco, California, concentrate a beam of sunlight upon a small papil- loma just inside the meatus urinarius of a patient recovering from gonorrhoea, using for that purpose a double convex lens. My inquiries elicited the fact that he had learned its use from a practitioner in that city, a Dr. Fryer, who had purchased it as the secret remedy of a cancer doctor, and who had employed it, presumably according to directions secured in the trade, in cases of carcinomatous breast, of epithelioma, and of lupus. I am not informed that positive diagnosis was reached in any of these cases by other means than gross clinical appearances, but a paper was read by Dr. Fryer on the subject of this treatment of maglignant disease before a local medical society, and one or more of his former patients were exhibited, illustrating cures. With this impetus I have collected the following observations bearing upon the subject, whose interest lies in their novelty and *A paper read before the Nashville Academy of Medicine, Aug. 4,1892. 2 iii their possible value as predictions, pending careful and reliable experimentation: A Russian observer has announced his discovery of anaesthetic effects in the electric light beam; and workmen at Creusot, France, where much electrical welding is done, have exhibited pathological conditions assigned to its intense and prolonged ac- tion. Its ability to penetrate into living tissues is shown by the possibility of laryngoscopy with the light applied to the neck over the larynx and by the common light-test for pus or for a neo- plasm in an antrum. Recently Tesla, the inventor of the first alternating-current dynamo, has produced an electrical current of from one million to two millions of vibrations per second, which has enabled him to dispense with Geisler's vacuum tubes in the production of light. This light, which appears to be unassociated with heat, and whose waves may be made nearly a foot long, passes between somewhat distant poles with the effects of the aurora; and vacuum bulbs placed between more widely separated terminals will glow bril- liantly. Actual contact with glass or other substances, as in Crookes' and Geisler's experiments, is unnecessary. It is hoped that the resistance of fog to this light may be overcome ultimate- ly. This approach of the rate of electrical vibration to the rate of light vibration has deprived electricity of its lethal effects upon the human body, however great its intensity or high its potential. Tesla, in his lectures in England and on the Continent, made contact with a terminal capable of giving a spark several inches long with an iron bar held in one hand and used his other hand as one of the plates for a light. A vacuum tube also held in this hand was made to glow very brilliantly by the current, which passed through his body and entirely failed to affect it. M. de Arsouval (La Semaine Medicale) reports the statement that one- five-hundredth part of the force of the current actually employed would have been instantly fatal. The absence of heat from the light thus produced recalls the discontinuous phosphorescence of some earths under high tension currents in high vacua and the voluntary brilliant intervals of the luminous segments of the abdomens of glow-worms and fire- flies, which last are accompanied with no sensible, or at least measurable, liberations of heat. 3 I shall not consider further the effects and properties of arti- ficial light; and by the unqualified word light I shall refer to that which emanates from the ultimate parent of life on'the earth, "the symbol and vice-regent of the Deity." The salutary effects of direct sunlight in moderate amount on animal life generally, are axiomatic, and in some other countries the sun exposure of a building or of a room influences greatly its commercial value. This idea has its foundation on the belief that the sun can and does destroy the germs of diseases that do, like sins, so easily beset us. In the most populous parts of Asia, open sewers, or rather no sewers at all, are used for the avowed purpose of securing the disinfection of the sewage by sunlight; and, while less remote objections to the system than Kipling's (in his poem "Municipal") will suggest themselves, some value must attach to the practical adoption of the idea. Sun baths, tinctured or otherwise, have shared in general the fate of tar-water, and for the same reason-the excessive zeal of their promoters. It cannot be determined at present how much or how little of the climatic benefits to pulmonary phthisis are ascribable to the sunlight, but its part in the open-air life, so strongly urged to all such sufferers, cannot be insignificant. In Peru, there is an establishment where syphilis is treated by the enforcement of a very meagre diet and profuse diaphoresis, induced by covering the patient with hot sand, until great reduc- tion in weight results: then prolonged exposure to the sun's di- rect rays is practiced with as little protection to the patient as is consistent with humanity. My informant, a naval officer of my own corps, much inclined to investigation of such matters, was disposed warmly to commend the results secured. He was satis- fied that no alterative medicine was used. Downes, Blunt, and Tyndall did not employ solely pathoge- nic organisms; and later experiments have shown that it is gen- erally true of these organisms that exposure freely to the light prevents their exuberant growth and the elaboration of their special deleterious product. Excluding the influence of the attendant heat, which may hinder bacteriological growth by dessication and destroy mildly resistant germs as heat, the disinfectant action of direct sunlight is well attested. 4 Ducleaux (JJhimie. Biologique Encyclop. Clinique, Paris, 1883.), with his great forcibleness has striven to draw attention to the prophylactic influences that light and air exert by disinfecting effluvia. German Sims Woodhead ("Bacteria and Their Products," p. 277.) makes this statement concerning anthrax spores, the stand- by for extreme resistance of bacteriologists: "The only other physical condition that appears to be fatal, or at any rate injurious, to anthrax spores is strong sunlight; this appears to deprive them in whole or in part of their power of further development in a most remarkable manner, always causing distinct attenuation of their pathogenic virulence before completely destroying them." Janowski (Centralbl. f. Balct. und Parasitenk. Bd. VI, Nos. 6-9, 1890.) found that the diffused light of a cold winter's day dis- tinctly hindered the growth of the typhoid bacillus in pure a cul- tivation in gelatine. He further proved that direct sunlight killed this organism in fluid cultures in from four to seven hours, diffused daylight requiring a much longer period to suspend their development and propagation This was entirely independent of any oxidation of their food material by the action of the chemi- cal rays of light, which appeared to affect their protoplasm di- rectly and to render them incapable of existence. By employ- ing various diathermanous and athermanous substances, he reached the conclusion that both sunlight and daylight held their hurtful influences upon this bacillus in their chemical rays, which agrees with the results obtained by Englemann, who, observing some motile chromogenic bacteria in fluid illuminated by the rays from a micro-spectral objective, found that they always moved to the red end of the spectrum to avoid, as it would appear, the chemi- cal rays at the violet end. The foregoing suggests a factor in the purification of the water of running streams not much emphasized at present. Though not to be relied on to purify drinking water, light's disinfectant ac- tion, from the exposed situation of most streams, must equal that of oxidation, of which so much has been said. The penetration of light into sea water in the smoothest weather is given as 1580 feet. Koch observed just prior to the promulgation of tuberculin 5 that tubercle bacilli would not grow on culture media in direct sunlight, and that it or even ordinary daylight was fatal to them in from a few minutes to several days. Even diffused daylight has a pronounced action in killing the Klebs Lbffler bacillus, while, in the presence of air, its ptomaine or toxalbumin is rapidly modified by sunlight. Some recent experiments with the virus of pneumonia in spu- tum (Bordoni Ufferduzzi, Centralblat f. Bakteriologie, X., p. 305.) indicate attenuation after twelve hours' exposure in a dessicated state to sunlight. With these attestations of its germicidal powers, let us consider the method of its application. For practical purposes the heat- rays can be filtered out of a beam of sunlight with a flat cell filled with a strong solution of alum, the most elegible ather- manous material; and concentration of the light may be increased about twenty fold before the painful effects of heat-concentration are experienced. (A common whisky flask free from flaws, filled with alum solution and a lens, such as is sold for examining pho- tographs, will serve for all minor purposes.) This degree of con- centration I have frequently employed on boils, warts, ringworms and the like, with instructive results ; although they are too in- exact from the trifling nature of the cases and from the absence of control experiments to describe them in detail. I have secured distinct escharotic effects from a greater degree of concentration, although cosmoline would barely melt at the focus of the lens, a temperature of about 125° F.; and that effect was attained in two cases with a slight pricking sensation hardly amounting to pain, although the entire thickness of skin was reduced to a whitish, pulpy mass. This agrees with the Russian's observation already referred to, and with Dr. Fryer's experience, in which the simple burning-glass was used without anaesthetizing the patient. The pain after a time was not complained of, not- withstanding the high temperature developed at the focus of the lens. He records as the principal objections to the treatment the unpleasant appearance of the operation and the odor and the smoke from the burning flesh. ' Since 120° F. is about the limit of usual toleration of moist heat, and since 145° F. dry heat produces nearly intolerable pain in one minute and in ten minutes causes quite active hyper- 6 semia, it is plain that the concentrated light, minus its grosser heat, is both amesthetic and escharotic, the last in a mild degree. In considering the former property, some allowance must be made for the effect of dessication, which, although hindered somewhat in this case by the transudation of serum, has an ad- mitted anaesthetic effect. The latter property manifests itself in in the severe blistering of the skin at elevations above the snow line and in small boats on the water in the tropics, being much severer in the early and in the late hours of the day, from the ob- lique position of the sun and the greater consequent reflection of its rays from the surface of the water. It is obvious that light will have its application almost confined to parasitic affections, if its action be shown to be sufficiently pow- erful to destroy the parasites and at the same time reasonably in- nocent to the tissues affected. If penetration to any degree be admitted, concentration may increase it to any desired extent. The destructive action of the heat may be removed as indicated above by athermanous substances, or it may be neutralized in situ, so to speak; for instance, with a spray of liquified carbonic acid gas. In many cases the associated heat may be advantageously re- tained, as when a large amount of tissue is to be destroyed. This form of cautery is said by Dr. Fryer, hereinbefore mentioned, to be followed by unusually slight inflammatory reaction, which might have been anticipated from the perfect disinfection of the eschar, and from the fact that it contains no residual chemical for absorption and for further local irritation-not an inconsider- able advantage where much destruction of tissue is necessary. Dr. Fryer has cauterized several square inches at a sitting, but he thinks the number should not exceed five. I should upon favorable occasion employ light with any desir- able modifications in the treatment of epithelioma, of whose infec- tious character I entertain no doubt ; and in the matter of pre- ferance to the knife I should have much good company. I should employ it instead of Kraske's incisions in the surgical treatment of erysipelas and test, with no ordinary interest and hopefulness, its ability to disinfect the localized lesions in man of anthrax, of chancroid, of diptheria, of tetanus, and of the infective gran- ulomata.