A CONTRIBUTION 
TO THE 
'Imtinic Properties of Dialized Iron 
BEING EXTRACTS FROM COMMUNICATIONS READ BEFORE THE BOSTON 
SOCIETY OF TEE MEDICAL SCIENCES AND TIIE BOSTON SOCIETY 
FOR MEDICAL OBSERVATION. 
BY 
ROBERT AMORY, M. D. 
Or Longwood, Mass. 
[Reprinted from the Boston Medical and Surgical Journal, April 3d, 1879.] 
PHILADELPHIA: 
Lehman & Bolton, Lithographers, Engravers and Printers. 
1881. 4- 
3 
17 
6 15 
23 
1 
10 
13 
21 24* 
2 
20 
16 
5 
8 9 
22 
12 
27 
7 
18 lO 
28 
14- 
25 
26 
11 TN reproducing the very interesting and valuable paper of Dr. Robert 
Amory, we present to the medical profession positive and scientific 
testimony to the efficiency of Dialyzed Iron, as made by us, in enriching 
the blood. We point, with what we think is pardonable pride, to the 
accumulated evidence of the therapeutic value of this preparation— 
evidence from all sections of our own country, from Great Britain, 
Canada and South America. Many practitioners, who had been led by 
the failure of other methods of administration to abandon the use of 
iron, have, upon our positive assertions, been induced to make trial of 
this article, and have found it in the highest degree satisfactory. We 
have devoted much time and attention to the subject, and have spared no 
expense in developing this manufacture. We have examined samples of 
that furnished by other makers, and confidently claim that they are 
without exception inferior to that which we offer. 
Hence, we ask physicians who wish to employ this valuable thera- 
peutical agent to be particular in specifying “Wyeth & Bro.’s Dialyzed 
Iron.” 
[copy.] 
Longwood, Mass., April p, i8yp. 
Messrs. Wyeth & Bro. 
Dear Sirs:—In answer to your inquiry as contained in your note of 
yesterday, I will say that in the experiments which are detailed in the Boston 
Medical and Surgical Journal for April jd, I used only the solution of 
Dialyzed Iron manufactured by your firm. 
Yours, respectfully, 
(Signed,) R OBER T A MOR Y EXPERIMENTS AND CLINICAL OBSERVATIONS 
ON THE 
Htmatinic Properties of Dialyzed Iron* 
ROBERT AMORY, M. D. 
Gowers’s hsemacytometer, the instrument I used in the following 
observations, consists of a glass slide, upon which are ruled squares one- 
tenth of a millimetre in extent, and these are inclosed in a cell one-fifth 
of a millimetre in depth. This slide can be used with any microscope, 
and with a lens of any desirable magnifying power; moreover, the 
magnified image of the slide may be projected, by means of a prismatic 
eye-piece, upon a screen. The principle of Malassez’s “ compte-globule ” 
does not admit of either of these convenient methods of delineation. In 
addition to the ruled slide, there are two pipettes, one of which holds 
nine hundred and ninety-five cubic millimetres, and the other five cubic 
millimetres. The principle and method of using this instrument are, 
then, based upon the following facts: If a known measure of blood be 
carefully drawn from an acupuncture, and intimately mixed with two 
hundred times its volume of a saline solution (specific gravity 1025), 
having a density sufficient to prevent the corpuscles from imbibing water, 
and so bursting their envelopes, these corpuscles, separated from each 
other, will float in this mixture, and will finally settle down to the bottom 
of the containing vessel or dish. 
In this manner a small portion of the mixed or diluted blood is 
placed in the above-described cell, and the corpuscles are allowed to 
settle to the bottom, so as to be nearly on the same plane as the ruled 
lines, and are pretty uniformly distributed. The number of corpuscles 
in ten contiguous squares can then be readily counted, and this sum 
multiplied by the figure ten thousand will give the number of corpuscles 
in each cubic millimetre of the pure or originally drawn blood; because 
ten cubes, each one of which has the dimensions tVxtVxP millimetres, 
(or -j-i-g- of a cubic millimetre), will contain of a cubic millimetre, and 
since the original blood was diluted with two hundred volumes, the 
number of corpuscles actually counted in the ten squares must be multi- 
plied by two hundred times fifty, or ten thousand, in order to obtain 
1 Read before the Boston Society of Medical Sciences, January 21,1879, and the Boston 
Society for Medical Observation, March 17,187j. Hoematinic Properties of Dialyzed Iron. 
3 
the number in each cubic millimetre of undiluted blood. If we wish still 
further to separate the corpuscles from each other, we may use four hun- 
dred volumes of the diluent to one of the blood, but in that case we must 
either count the corpuscles in twenty squares and multiply by ten thousand, 
or count those in ten squares and multiply by twenty thousand. 
The individual or personal error of vision which is associated with 
all optical instruments is, perhaps, somewhat difficult to reduce to mathe- 
matical accuracy, on account of the fact that constant observation fatigues 
the eyesight, and hence the results of a series of these observations are 
subject to an inconstant variation. In consequence of this apparent 
difficulty, I decided to project upon a photographic plate the image of 
the corpuscles on the ruled slide, then to print from the negatives, and 
count upon the print the number of these corpuscles, each one being 
obliterated as soon as counted. 
To show the range of error of this method of obtaining the propor- 
tion of globular richness of the blood, I will call your attention to the 
prints Nos. 1, 2, 3, 4, which were all taken from blood of the same 
individual from four different punctures, separately diluted, and a sample 
from each dilution separately photographed. 
No. 1 shows 4,656,000 corpuscles per cubic millimetre.1 
No. 2 “ 4,750,000 
No. 3 “ 4,633,000 
No. 4 “ 4,673,000 “ “ • 
The greatest difference between these four results being only 117,000, 
shows less than three per cent, of variation. Again, in three separate 
jjhotographs, taken from one sample on the same slide, a field at either 
periphery, and at its centre, the variation was even less than that above 
mentioned. Thus, so far as this method is concerned, the error of varia- 
tion may be placed within three per cent. 
Hearing from certain members of our profession expressions which 
indicated a skeptical distrust in regard to the virtues of the solution of 
dialyzed iron, I was induced to undertake a series of observations upon 
the hoematinic properties of this medicinal agent, and yet I must frankly 
acknowledge in advance that my own clinical experience with this form 
of iron had led me to attach to it a value in simple anaemia, and to place 
this remedy by the side of Quevenne’s Iron. I have taken pains to 
inquire how much metallic iron is contained in the so-called dialyzed 
iron, and learn that a sample of the scaled dialyzed iron, as prepared by 
one of our large wholesale druggists, has been analyzed by Prof. Charles 
M. Cresson, of Philadelphia, and that he found it to contain fifty-two 
1 A reference to the prints will show not more than sixteen squares represented. On the 
original photographic prims presented at the meetings the count gave an average for twenty- 
five or thirty squares. To have reproduced this number of squares in each heliotype print 
would have required too much room. Hence a discrepancy between the numbers of corpuscles 
mentioned in the text and what may be counted in the illustrations may be explained. 4 
Properties of Dialyzed Iron. 
per cent, of metallic iron, or over seventeen per cent, more than is con* 
tained in the sesquichloride of iron ; compared with the sesquichloride, 
it is equally soluble, keeps without change, does not corrode the teeth 
or fabrics with which it may be brought in contact, and contains a greater 
percentage of iron. The manufacturer from whom this sample was 
obtained claims that his solution of dialyzed iron has over twenty grains 
of ferric oxide in each ounce of solution, and in proof of this has shown 
me a certificate from Prof. F. A. Genth, of the University of Pennsylvania, 
that a sample of his manufacture, which was purchased by the latter from 
a retail druggist of Philadelphia, contained 21.69 grains of ferric oxide in 
each ounce of solution. 
The following table of assays of various iron preparations was made 
by M. Quevenne. One gramme (fifteen grs.) of the following prepara- 
tions was soluble in two hundred grammes of gastric juice, in the 
proportions named : — 
Of 1.0 iron by hydrogen containing 1.000 pure iron was dissolved 0.102 pure iron. 
Of 1.0 iron filings “ 1.000 “ “ 0 070 
Of 1.0 protosulphate of iron “ 0.210 “ “ 0.056 
Of 1.0 protocarbonate “ “ 0.490 “ “ 0.050 
Of 1.0 persulphate “ “ 0.250 “ “ 0.046 “ 
Of 1.0 lactate “ “ 0.190 “ “ 0.040 
Of 1.0 protochloride “ “ 0.430 “ “ 0.036 
Of 1.0 tartrate of iron and 
potass “ 0.210 “ “ 0.022 “ 
Of 1.0 oxide of iron heated 
to red heat “ 0.700 “ “ 0.016 
Forty parts of scaled or dialyzed iron, from which water had been 
withdrawn without aid of heat, was levigated very fine and placed in an 
artificial gastric juice prepared as follows: five parts hydrochloric acid 
and acetic acid, fifteen parts of pure pepsin, with traces of chlorides of 
sodium, potassium and ammonium; also phosphates iron, lime and mag- 
nesium, in one thousand parts of water ; and temperature was maintained 
at ioo° F. for five hours, then filtered through a “fared” filter, dried 
and weighed, showing a loss of iron amounting to fifteen parts. This 
shows that 3.00 grammes of scaled dialyzed iron (containing 1.5 grammes, 
pure iron) are soluble in two hundred grammes of gastric juice. 
Having thus compared the properties of dialyzed iron with other 
well known preparations, I will report five cases only, in which I observed 
its effect upon the globular richness of the blood. These were cases of 
simple anaemia uncomplicated by organic disease, and none of the indi- 
viduals were placed upon any regimen of diet or exercise, but were 
allowed to continue their usual habits of life. My object was to prevent 
the error of attributing any improvement in health or appearance to an 
improved diet, or to the more favorable effects of fresh air and exercise.  Properties of Dialyzed Iron. 
5 
I selected those cases in which I could personally observe the individuals 
from day to day, and could note any peculiarity of symptoms or unusual 
mode of life. The instrument which I imported from London was so 
inaccurate that I was forced to abandon it, as well as the reports of three 
cases in which it was used, and obtained from Prof. W. A. Rogers, of 
Harvard College Observatory, some very accurately ruled glass slides. I 
also procured some pipettes, and carefully estimated their capacity, so 
that I could place more reliance upon their measurements. I took especial 
care in the photographs herewith presented not to use various pipettes or 
ruled slides in the same individual; in the few cases in which (owing to 
accidental breakage) I was obliged to use more than one set of apparatus, 
the second set was carefully measured anew, so that my comparative 
results should not be invalidated. 
The circumstances under which the blood was taken from the patient 
were a? nearly similar as possible, and I have a strong confidence that the 
results of my observations are not materially affected by the method of 
procedure, and that the error of variation may be safely placed within five 
per cent. I have not the time in this communication to prove the grounds 
for this statement, nor would it be worth your while to examine the 
details of experiment which were used to determine my opinion. The 
pains that have been taken may, perhaps, be better appreciated by the 
careful examination of two hundred photographs, taken under various 
circumstances and conditions, among which may be mentioned the tem- 
perature of the surface after exposure to dry and wet heat and cold; the 
depth and method of puncture of the skin, blood taken while the patient 
was depressed by pain or temporary disturbances of other sorts, during 
the menstrual flow, and before rising from bed in the morning. The 
variation shown in these photographs is not, to my knowledge, dependent 
upon any of these disturbing causes. 
Case I Is that of a woman whose appearance was anaemic, and, as 
far as I could learn, had no organic disease. An earlier examination of 
her blood had shown about 3,900,000 corpuscles per c. mm. of blood, 
but this negative was unfortunately lost. The print No. 5 was taken on 
the third day after the commencement with the solution of dialyzed iron. 
I have estimated in this 4,189,000 corpuscles per c. mm., or about eighty- 
three per cent, of the normal state, of health. At first she took her 
medicine quite regularly, and in ten days gained 171,000 corpuscles, her 
blood having attained a per centage of eighty-six. The following six 
days she took the medicine very seldom, and lost 500,000 corpuscles, and 
was in the same anaemic condition as before treatment, having a percent- 
age of seventy-six. From this time onward she took the medicine more 
faithfully, but still omitting one dose about every two or three days, and 
in five days regained 440,000 corpuscles, having now a percentage of 
eighty-four. In another week she gained 60,000, and in four days more 6 
Properties of Dialyzed Iron. 
160,000, having then a percentage of ninety-six. In the whole period, 
from December nth to January 10th, this patient showed an increase of 
1,000,000 corpuscles, or an improvement of twenty per cent. During the 
whole time she was under observation she menstruated twice, but appa- 
rently with very slight effect upon the globular richness of the blood. 
None of these prints, Nos. 5, 6, 7, 8, 9, 10, 11, were taken during, 
menstruation :—• 
No. 5. December 5th, 4,189,000, or 83 per cent. 
No. 6. “ 13th, 4,360,000, or 87 per cent. 
No: 7. “ 19th, 3,850,000, or 77 per cent. (Has taken iron seldom.) 
No. 8. “ 24th, 4,240,000, or 84 per cent. 
No. 9. “ 31st, 4,630,000, or 92 per cent. 
No. 10. January 6th, 4,820,000, or 96 per cent. 
No. 11. “ 10th, 4,860,000, or 97 per cent. 
Case II Is that of a girl about sixteen years of age, who consulted' 
me for neuralgia, dizziness, especially during the act of stooping, lassi- 
tude and general malaise ; she had the habit of awaking with a slight 
headache, which, towards the latter part of the day, forced her to leave 
her regular household duties. She had been out to walk two or three 
times a day, and, like all the other cases, had but slight loss of appetite, a 
good home, good food, warm clothing, without much requirement for 
excessive mental or physical work. Her catamenia occurred too frequently 
— once in three weeks. Without advising any change in diet or occupa- 
tion, I gave her in water, as in all the other cases, thirty drops of 
dialyzed iron solution three times a day. I may as well say here that I 
obtained the solution of dialyzed iron always from the same manufacturer, 
furnished it directly to each patient, and that it had a uniform standard 
and purity, so far as I could determine. Its specific gravity was 1042, 
and in two instances the solid residue was about twenty-four grains to the 
ounce of solution. The record of Case II is estimated from the prints: — 
No. 12. December 16th, 4,070,000, or 80 per cent. (Began treatment.) 
No. 13. “ 20th, 4,220,000, or 84 per cent. 
No. 14. “ 28th, 4,370,000, or 87 per cent. 
No. 15. January 6th, 4,620,000, or 92 per cent. (Discontinued treatment.) 
No. 16. “ 15th, 4,500,000, or 90 per cent. 
All her anaemic symptoms, above mentioned, gradually disappeared, 
and she omitted the treatment because she felt well, and up to the present 
time none of these symptoms have reappeared. 
Case III Is that of a young woman about twenty years of age, pale 
and thin in appearance, who has at previous times been much improved 
by a ferruginous tonic treatment. She complained of languor, dizziness, 
muscular fatigue, cold, moist hands, painful menstruation, etc. Estimates 
from prints:—  Properties of Dialyzed Iron. 
7 
No. 17. December 17th, 3,700,000, or 74 per cent. (Began treatment.) 
No. 18. “ 31st, 4,700,000, or 94 per c<nt. 
No. 19. January 15th, 4,200,000, or 84 per cent. (Having a headache.) 
No. 20. “ 17th, 4,600,000, or 92 per cent. 
Apparently, on January 15th, her headache caused a diminution in 
globular richness, and for the sake of comparison I show print No. 21 of 
my own blood, taken during a headache : ordinarily my blood shows over 
5,000,000 corpuscles per c. mm. The number estimated by this print is 
only 4,350,000. 
Case IV Is that of a clergyman, who had been suffering from 
neuralgia, headache, an uncomfortable feeling of pressure in the head, 
and general malaise; these symptoms were aggravated after mental or 
physical work. Though actively engaged in his professional duties, he 
led a healthy life, took daily exercise, eating well and at regular times. 
He had been taking, a few weeks previously, Carlsbad water, though he 
had no indigestion or constipation. His record is as follows: Omitting 
Carlsbad water, he began, December 3d, dialyzed iron solution—half a 
teaspoonful, diluted with water, three times a day after meals, and taken 
regularly; he omitted only one dose during five weeks’ treatment. The 
estimate from the prints is:— 
No. 22. December 3d, 3,800,000, or 76 per cent. 
No. 23. “ 13th, 4,500,000, or 90 per cent. 
No. 24. “ 28th, 5,191,000, or 103 per cent. 
No. 25. January 6th, 4,900,000, or 98 per cent. 
No. 26. “ 16th, 4,500,000, or 90 per cent. (The day after a headache, « 
and iron omitted.) 
This was the only headache he had while taking the iron, and his 
professional work about Christmas time was excessive. 
Case V A married woman, who has had chlorosis and anaemia for 
several years, her appearance being white and bloodless, has been a patient 
of Dr. Sabine’s for two years, and her chronic anaemia has been a marked 
feature ; apparently, she has no organic disease other than this impoverish- 
ment of blood. Figure 27 indicates that the globular richness of blood 
is only 3,350,000, and at that time she began treatment by dialyzed iron. 
On one of the last days of February she had diarrhoea, with some catarrh 
of intestines, which was controlled in two or three days by ordinary doses 
of morphine and chalk mixture. On March 3d, after a fortnight’s use of 
the solution of dialyzed iron (Figure No. 28), her globular richness had 
improved to 3,560,000, in spite of the diarrhoea. On March 19th another 
examination showed 3,6000,000 corpuscles per c. mm. 
There certainly is good reason for saying that four or five cases are 
insufficient to establish definitely that the solution of dialyzed iron cures 
anaemia. However, an analysis of the history of these cases shows that 
all the individuals were in comfortable circumstances, as far as focd, 8 
Properties of Dialyzed Iron. 
clothing and homes were concerned; that none of them had any organic 
disease (if we except simple impoverishment of the blood); that they 
were aware of being out of their usual health; that they were unable to 
accomplish their regular work; that none had impaired appetite, nor 
feeble digestion; that three of the four suffered from neuralgia or head- 
ache ; finally, all had diminished corpuscular richness of blood, varying 
from 3,350,000 to 4,000,000, and that under the continued use of ninety 
drops of solution of dialyzed iron per diem this condition of impoverished 
blood was replaced by an increase in the number of corpuscles from 
3,600,000 to 4,900,000, and the symptoms of ill health simultaneously 
disappeared with this improvement. 
Dialyzed Iron may increase the globular richness of blood, but it 
may have no effect in bringing about the chemical combination of oxy- 
hemoglobin. If the supposition be true that there is a state of ill health 
in which the corpuscles may be numerically normal, but may simulta- 
neously be deficient in coloring matter, we may conceive of an anemic 
or chlorotic patient who may require some therapeutical means for 
improving this deficiency other than simple iron. I may have been 
extremely fortunate in selecting just those cases in which a simple form of 
iron was indicated, and it may not be impossible that another form would 
have benefited my cases as much as the dialyzed iron ; yet the latter is 
preferable to the more astringent iron salts, because it does not impair the 
digestion, nor produce constipation. 
I cannot close my communication without an expression of thanks to 
Dr. Sabine and my laboratory assistant, Mr. J. G. Hubbard, whose 
material assistance lent much to the value of the record of these experi- 
ments. 
Now, one final word about the various solutions of dialyzed iron. 
Many of these solutions are valueless, some are very dilute, and a few are 
of pretty uniform standard, and contain only the products of dialysis from 
a salt of iron and distilled water. If physicians use a worthless prepara- 
tion, they need not expect an improvement in the anaemia; if they use a 
dilute solution, they must prescribe a larger amount of the solution.1 In 
the preparation I used for these experiments the solution had a specific 
gravity of 1642, and had no free acid. 
1 See Boston Med. and Surg. Journal, Sept. 21, 1878. Wyeth’s Dialysed Iron, 
(FEE.E.T73VC UI.A.Ij-X'SjVTTriM:,) 
A Neutral Solution of Oxide of Iron in the Colloid Form, 
the Result of Endosmosis and Diffusion with 
Distilled Water. 
About two years ago we placed before the medical profession of the 
United States our preparation of Dialysed Iron. The practical working 
of our appliances enables us to prepare it on any required scale, and of a 
uniform quality, in every respect equal to the highest standard of the well 
known chemists who have given it a trial in hospital and private practice, 
under the observation of some of the most eminent physicians of this and 
other cities, fully justifying us in claiming, in our circulars and in our 
correspondence with physicians and druggists, many advantages possessed 
by our Dialysed Iron over all the ordinary ferruginous preparations. 
These advantages are:— 
1. It is easily administered—the dose being very small. 
2. It has no unpleasant taste or smell. 
3. It does not irritate the stomach. 
4. It has no effect on the bowels, producing neither constipation 
nor diarrhoea. 
5. It does not blacken the teeth. 
Immediately upon the introduction of this article by us, and the 
recognition so generally accorded to its merits, other manufacturers began 
offering to the drug trade preparations which were called Dialysed Iron, 
and which were asserted to be equal in every respect to ours. We con- 
fidently maintain, however, that no reliable article of this kind can be 
made except by the process of dialysis. The digesting of an acid solution 
until it is neutral will by no means result in a preparation at all identical 
with our Dialysed Iron. We have, at great expense, perfected an appa- 
ratus which enables us to produce this article on a large scale. So delicate 
is the process of manufacture, and so important did we consider the purity 
of the water used to accomplish the endosmosis, that we bored an artesian 
well to supply our dialysers. 
Our Dialysed Iron is not a saline compound, and is easily distin- 
guished from salts of iron by not giving rise to a blood-red color on the 
addition of an alkaline sulpho-cyanide, or to a blue precipitate with ferro- 10 
Hasmatinic Properties of Dialysed Iron. 
cyanide of potassium. It does not become cloudy if boiled. When 
agitated with one part of alcohol and two parts of ether (fortior), the 
ether layer is not made yellow. 
We cannot assume the responsibility of the claims put forth for this 
preparation, except for that manufactured by us. 
The following jnay be adduced from among many testimonials 
received by us from physicians who have employed this remedy: 
1524 Walnut Street, Philadelphia. 
To Wyeth & Brother. 
Gentlemen:—I am glad to be able to say that now, after much more prolonged 
use of your Dialysed Iron, I have more and more reason to be pleased with it. As I 
use the solution in drachm doses, I have had a fair chance of testing its power to- 
disturb the patient’s functions. So far, however, even in these large doses, it does not 
seem to constipate, nor to affect injuriously the process of digestion. 
Yours truly, 
WEIR MITCHELL. 
“An extended trial of the Dialysed Iron prepared by Messrs. John Wyeth & 
Brother has convinced me that it is a most valuable addition to the Materia Medica, 
and likely to supersede, in great degree, the chalybeates heretofore employed. 
The results obtained from it under my observation have been such as to fully 
justify the strong claims of the manufacturers in its behalf.” 
JOHN II. PACKARD. 
1924 Spruce St., Philad'a., Nov. 7, 1S77. 
Dr. Baldwin, editor of the Ohio Medical Recorder, in an editor’s, 
note to an analysis of Dialysed Iron by Dr. Robert Amory, published in 
the Boston Medical and Surgical Journal, writes as follows: 
“We have prescribed Dialysed Iron frequently, and have, apparently, at least, 
secured as good results, as by the use of the tinct. ferri chlor. Our patients have never 
complained of any unpleasant effects, except on a few occasions, and then, on inquiry, 
we have ascertained that the druggist had not dispensed Wyeth’s preparation. Of' 
late, therefore, we have always indicated ‘Wyeth’s’ on our prescriptions. B. 
Dr. T. A. Emmet (“Diseases of Women,” p. 549,) speaking of 
fibrous growths of the uterus, says: 
. “In the treatment of two cases, recently, I have been particularly pleased with 
the marked improvement following the use of Wyeth’s preparation of Dialysed Iron. 
In both instances other forms of iron had caused headache and constipation, and aa 
unexpected loss of blood.”  Properties of Dialysed Iron. 
II 
Dr. \V. Pepper, of Philadelphia, in a communication to the 
Pennsylvania State Medical Society in 1879, reporting several cases of 
exophthalmic goitre, says: 
‘‘So much discussion has occurred as to the value of Dialysed Iron, and my own 
experience with it in suitable cases has been so gratifying, that I take pleasure in 
pointing to the marked effects which, in cases II and III, are certainly in large part 
to be attributed to its action.” 
‘‘Dialysed Iron.—I have used about ten or twelve pounds of Dialysed Iron, 
mostly Wyeth’s, and am much pleased with the results. I find it both agreeable and 
reliable, and for many cases prefer it to any other ferruginous preparation. I have 
given it to persons, with good effect, who affirmed that they ‘could not take iron, as 
it always made them sick.’"—Dr. Q. C. Smith, in Pacific Med. and Surg. Journal. 
Lunsford P. Yandell, M. D., Professor of Therapeutics and Clinical 
Medicine in the University of Louisville, says, in the Louisville Medical 
News, April 27th, 1878 : 
“A year since, when Dialysed Iron was a novelty, I commended it in the News as 
a most valuable addition to the Materia Medica. Twelve months of additional expe- 
rience have confirmed my faith in its excellence. The object of this note is to call 
attention to the great variety of spurious preparations sold under the name of Dialysed 
Iron. In this city, I have found nine varieties of so-called Dialysed Iron. Some of 
these were manufactured here, but most of them were made elsewhere. Genuine 
Dialysed Iron is nearly tasteless. It has the faintest possible saline flavor, and a mere 
suspicion of roughness. Slightly diluted, its taste recalls that of fresh blood. It is not 
in the least unpleasant, and does not blacken the teeth or tongue. It seldom or never 
produces any gastric disturbance cr headache, and very rarely constipation. It is- 
exceedingly reliable and rapid as a tonic. 
“ The spurious forms of this drug are without the characteristics of taste and 
efficacy above enumerated, and chemical analysis readily detects their deficiencies. 
One of the spurious specimens before alluded to was little less unpleasant than the- 
tincture of muriate of iron; another was excessively acid; another was decidedly 
saline; another was exceedingly astringent; another was sweetish; another was bitter, 
and another was, seemingly, only colored water; another more nearly approached 
correctness, but only a single specimen possessed the peculiarities of the true article. 
“ My attention was first directed to this matter through the failure or misbehavior 
of the Dialysed Iron in practice. It is but just to say that the good specimen is from 
WYETH & BROTHER, the original manufacturers of this medicine in America. 
Wyeth’s Dialysed Iron sells at about a dollar a pound. Other makes may be bought 
at fifty cents.” 
Dr. Yandell also says, in a letter written by him from Cork, Ireland, 
whither he went as a delegate to the British Medical Association: 
“ Wyeth’s Dialysed Iron is preferred to all others in Cork, as it is in Dublin and 
London, and when I inquired of Corbyn, Stacy & Co., of London, who have a good 
exhibition of drugs at the Cork meeting, for a specimen of their own Dialysed Iron, 
they gave me a specimen of Wyeth’s, stating that it is chiefly prescribed in London.” 12 
H.ematinic Properties of Dialysed Iron. 
Besides the above, the following leading medical journals give ample 
recognition and endorsement of that manufactured by us: — 
The Philadelphia Medical Times. 
The New Orleans Medical and Surgical Journal. 
The Virginia Medical Monthly. 
The American Journal of Pharmacy. 
The Louisville Medical News. 
The Louisville Medical Journal. 
The Poston Journal of Chemistry. 
The Ohio Medical Recorder. 
The Canada Journal of Medical Science. 
The Pacific Medical and Surgical Journal. 
The Philadelphia Druggist and Chemist. 
The Oil, Paint and Drug Reporter. 
We give below the opinions of British Medical Journals on our 
Dialysed Iron : 
Report on the Preparation of Wyeth Bros., Philadelphia and London, 
by C. R. C. Tichborne, Ph. D., F. C. 8. 
“Dialysed Iron.—Messrs. Wyeth have succeeded in making a very excellent 
preparation, which is quite as good as any we have seen, and superior to many of them. 
In fact, some of the preparations known as Dialysed Iron have been shown to be of 
the most variable composition. Vide paper read at the late meeting of the British 
Pharmaceutical Conference at Dublin, and Pharmaceutical Journal. It seems to vary 
from a weak liquor ferri mur. to solutions, which according to Dr. Yandell, of Louis- 
ville, are nothing hut colored water. Our analysis of Wyeth’s preparation gave:— 
Perric Oxide (in the soluble form), ..... G-S^ 
Chlorine, ........... icq 
Water, 93.G72 
Total, •- 100.000 
We may say, therefore, that it contains in the fluid ounce, 27.68 grains of a basic 
salt of iron, which strange to say, almost exactly agrees in composition with the results 
obtained by Graham. In his experiments he obtained a red liquid containing 98.5 
parts of oxide, and 1.5 of muriatic acid. The salt contained in Wyeth’s preparation, 
contains 98.42 ferric oxide, and 1.58 of chlorine. 
We have found Wyeth’s Dialysed Iron to he a pure and concentrated solution, 
which has been well prepared.”—British Med. Press and Circular. 
“Wyeth’s preparation is excellent. We find, on analysis, that the proportion of 
Hydrate to Chloride is so high, that the latter can hardly produce any effect. If for 
no other purpose, Dialysed Iron should always be kept as an antidote for Arsenical 
poisoning.”—The Lancet. 
“ Wyeth’s preparation of this very valuable ferruginous preparation is one of the 
best we have seen; and as there is much evidence that preparations of so-called 
Dialysed Iron, of very inferior quality, are in use, this one deserves attention.”— 
British Medical Journal. 
“We have found Wyeth’s Dialysed Iron to be a pure and concentrated solution 
which has been well prepared. It contains in each fluid ounce 27.63 grains.”— 
Analytical Report by Prof. Tichbornc, Ph. D., F. C. S., to Medical Press and Circular. 
“A very superior preparation of Dialysed Iron, of which Messrs. Wyeth are 
perhaps the largest makers in the world.”—The Chemist and Druggist. DIALYSED IRON 
AS AH 
Antidote for Arsenical Poisoning 
The value of Dialysed Iron in this very important and frequently 
recurring class of cases is established beyond question. We append only 
a few out of a large number of instances which are upon record, or have 
been reported to us : 
A Case of Arsenical Poisoning Treated with Dialysed Iron 
by Thos. B. Reed, M. D. 
Philadelphia, November 15, 1877. 
As I was leaving my office one morning, a few weeks ago, a young lady patient. 
Miss S., hastily entered, with a face indicative of intense pain and nervous disturb- 
ance, saying, “Doctor, I am poisoned.” Her story was as follows: While attending 
to the wants of a valuable servant who was sick and confined to her bed, Miss S. 
found hidden away in the servant's trunk, a paper of Arsenious Acid, which had been 
procured by Mrs. S. some weeks before, for use as a poiscn for rats. As this servant- 
had been in ill health for some time, and morbid and melancholy, Miss S. at once very 
naturally, and no doubt very rightly supposed, that she had secreted the poison for the 
purpose of taking her own life. Quietly placing the packet of arsenic (which was 
open) in her pocket, she continued her duties, intending at the earliest moment to put 
it in a safe place. Days elapsed ; the arsenic was forgotten, stored away in the pocket 
of her wrapper, until this unlucky morning, when, putting a couple of handfuls of gum 
drops and bon-bons into her arsenic pocket, she sat down to her sewing machine and 
her confectionery. She noticed from time to time, as she sewed, more powder upon 
the drops than seemed usual, but she continued quietly to dust them off as she ate, and 
went on with her work. Can anything he more absurdly tragic than this unconscious 
suicide, deliberately eating gum drops powdered with arsenicf Probably an hour and 
a half passed in this innocent amusement, when suddenly, “becoming deathly sick, 
instantly followed by intense pain, as if,” as she quaintly expressed it, “she had had a 
pure mustard plaster on the inside of her stomach,” she was roused to the conscious- 
ness that some strange mischief was at work. Terrified, on remembering the arsenic, 
she attempted, unsuccessfully, to relieve her stomach with warm water; then, unwill- 
ing to alarm her mother, who was also an invalid, she hastily threw on her street dress 
and hat and hurried to my office, about two blocks away. Fortunately for both of us, I 
had upon my table a sample bottle of Dialysed Iron, (John Wyeth & Bro.) and as 
soon as she told me she had taken arsenic, and before she began her story, I adminis- 
tered half a tablespoonful of the Iron, well diluted in a tumbler of water. This gave 
her almost instant relief. I repeated the dose in ten minutes, and then gave her a 
bottle of the Iron, directing her to take a similar dose every half hour, and later, 
every hour during the day. I saw her at her home in a few hours after, but she had 
had no return of her pain, except some slight cramp in the lower bowel and limbs; 
and a dose of magnesia at night, with mucilaginous drinks, soft food, with occasional 
doses of the Iron well diluted, kept up for a few days, completed her cure. 14 
Hzematinic Properties of Dialysed Iron. 
Dr. Wm. B. Hazard, editor of the St. Louis Clinical Record, in an 
editorial note to an article on Dialysed Iron, published in the Cincinnati 
Lancet and Clinic, Oct. 26, writes as follows: 
Editor’s Note on Dialysed Iron in Arsenical Poisoning. 
“ During the first week in September, 1878, the writer was called to see a case of 
poisoning by arsenious acid. The patient was a young man, aged about twenty-five 
years, who had ingested a large quantity of the poison that had been used by mistake 
in the place of baking powder, in the composition of griddle cakes. The poison had 
been taken at about eight o’clock A. M. He had been seen shortly afterwards by a 
most competent physician, who had given him several ounces of the hydrated sesqui- 
oxide of iron. Vomiting had persisted all day, and, when seen by the writer at five 
and a half o’clock P. M., he was still nauseated, and ejected the smallest quantities of 
liquids almost as soon as taken. He had discontinued the hydrated sesquioxide about 
an hour before. There was extreme tenderness over the epigastrium, and constant 
-desire to drink. 
The writer immediately commenced the administration of Wyeth’s Dialysed Iron 
in drachm doses, given with a tablespoonful of ice-water. He vomited only two or 
three times after this treatment was instituted. At about seven o’clock, he was given 
a mixture of subnitrate of bismuth and aqueous extract of opium, to lessen the pain 
and irritability of the stomach. As soon as it could be retained, sulphate of magnesia 
was given in small doses, until the bowels were moved freely. The patient was 
intensely jaundiced next day, and some irritability of the stomach persisted for two or 
three days. Ilis recovery was satisfactory. 
The Southern Clinic, of January, 1879, contains the following account 
of two cases of arsenical poisoning treated with Dialysed Iron, by O. A. 
Crenshaw, M. D., Richmond, Ya. : 
Driving up Second Street at 11 A. M., December 22, I met a man hastily in search 
of a doctor. He stated that his two children had been poisoned, half an hour pre- 
viously, by ratsbane. I hastened to the house, a couple of blocks off, and found a girl 
nine years of age sitting over a basin, into which she bad vomited a large quantity of 
undigested bread, in lumps, and a considerable quantity of a yellowish liquid. The 
other sister, aged eleven, had not been sickened. 
I immediately gave the younger girl a mustard emetic, which acted instantaneously, 
and dispatched her father to the nearest drug store for some Dialysed Iron. He 
returned in a few minutes, and I gave her one teaspoonful in half a glass of water, 
with directions that it should be repeated every half hour. Also ordered the elder 
girl to be vomited, and treated as the other, with Dialysed Iron. 
Saw the patients again at 2 P. M., and learned that the eldest girl had com- 
menced vomiting before the emetic could be administered. It was given, however, 
and both kept on the iron treatment. Both had vomited occasionally, during my 
absence, and the younger, who was said to have eaten most heartily of the bread, was 
suffering with fever, restlessness, thirst and burning heat in the region of the stomach. 
The elder suffered comparatively little, and was free of fever. Ordered the iron con- 
tinued every half hour, as before, and the free use of milk. 
At 8 P. M , saw the patients again—the elder girl entirely relieved; the younger 
still suffering with fever, thirst and great restlessness. Treatment continued.  Properties of Dialysed Iron. 
15 
Dec. 23.—Visited patients at 10 A. M. Found that the elder girl had gone to 
school, and the younger up, and entirely free from all symptoms of poisoning, with an 
appetite for breakfast. 
The rapidity of recovery, in these cases, speaks volumes in favor of Dialysed Iron 
in the treatment of arsenical poisoning. The quantity of arsenic incorporated with 
the bread, which these children had baked and eaten, was one teaspoonful, and though 
it is true that much of the bread was vomited undigested, yet, from the quantity of the 
yellowish liquid vomited along with the bread, and the severity of the symptoms, a 
considerable quantity of the arsenic must have come in contact with the mucous mem- 
brane of the stomach. 
I was induced to use the Dialysed Iron because of the facility with which it could 
be procured—not more than five minutes elapsing between the writing of the prescrip- 
tion and the administration of the first dose. In the treatment of such cases, time is 
everything, and that lost in preparing the ordinary antidote, might have cost the life 
of one or both these patients. That Dialysed Iron, in addition to its other virtues, is 
an antidote for arsenical poisoning, I have no doubt. 
[It gives us great pleasure to add, that we have just learned from Dr. Crenshaw 
that the Dialysed Iron used in these cases was prepared by Messrs. John Wyeth & 
Bro., of Philadelphia.—Ed.] 
Editor Medical and Surgical Reporter:—An elderly gentleman and his wife were 
poisoned, last week, by arsenious acid put in their coffee, from which they suffered 
very severely. Mr. C. drank a cup of the coffee, and also a glass of sweet milk, at the 
table, and immediately after rising from the table he drank two more glasses of milk, 
with cream, not apprehending poison. In less than thirty minutes he became sick, 
nauseated and threw up his dinner. Supposing he was bilious, or had eaten something 
indigestible; he took a dose of calcined magnesia, and soon threw that up; then drank 
a solution of sodae carb., which was likewise thrown up. Mrs. C. was also seized with 
nausea and vomiting, when a physician was called in, who treated the nausea and 
irritability of the stomach, not apprehending poison, for the lady was not well before 
taking the poison. Mr. C. did not suffer many hours, as he had unwittingly taken 
three very good remedies. Mrs. C. was extremely prostrated; she is about sixty years 
’ old, and in poor health generally. The poison was taken on Monday at noon, and 
she continued to vomit and suffer till Thursday, when I sent her, in the evening, two 
ounces of Dialysed Iron, prepared by Wyeth, of which she took nearly a fluid drachm, 
and experienced great relief in a few moments. She repeated the dose before bedtime, 
and rested better than she had since Sunday night. I saw her on Friday, when she 
was able to sit up, and expressed her thanks for the medicine and the prompt relief it 
gave her, for she vomited no more after the first dose She continued to use the iron 
till restored to health. 
Dialysed Iron as an Antidote to Arsenic. 
JVavasota, Texas. 
A. R. KILPATRICK, M. D. 
A Case of Arsenical Poisoning Treated with Dialysed Iron. 
I send you the history of a case of arsenical poisoning, which occurred in this 
City, thinking it may interest some of the readers of your valuable journal: 
On the 22d day of March last, I was summoned to visit Mrs. J. A. McK (a 
married woman, about twenty-four years of age,) who, the messenger said, had taken 
arsenic, with sw'cidal intent, and I immediately repaired to her dwelling. She was 16 
H/ematinic Properties of Dialysed Iron. 
reclining on a lounge, attended by her husband and several female acquaintances—a 
picture of anxiety and distress. Her haggard face, clammy skin and feeble pulse 
plainly indicated the necessity of prompt medical assistance, as gastric pain and 
uneasiness, with continual hiccough, were already prominent symptoms. I offered 
her some water, and noticed that the power of deglutition was considerably impaired. 
Having no antidote with me, I wrote on a slip of paper “ Wyeth’s Dialysed Iron,” and 
giving it to her husband, directed him to a drug store near by, where I knew he would 
find this reliable preparation. In a few minutes he returned, and I administered two 
or three tablespoonfuls of the solution, each well diluted. She showed no inclination 
to vomit, but a mixture of powdered alum and ground mustard, in conjunction with 
tepid drinks and tickling of the fauces, caused the stomach, after a while, to eject its 
contents freely and fully. The remaining treatment consisted in the employment of 
remedies calculated to lessen irritation and strengthen the nervous system—milk, 
opium and small doses of the iron for a period of twelve hours. I was of course 
unable to determine the exact amount of arsenic which my patient swallowed, but I 
think certainly ten or fifteen grains, judging from her own statement and the appear- 
ance of the partly emptied package, which was accidentally discovered before I left. 
She recovered in a few days. 
Freeport, III. 
H. N. CANER. 
We have information of the recent occurrence, in one family residing 
near Jersey City, N. J.,of three cases of poisoning by arsenic (Paris green) 
contained in some raw tomatoes, all of which were immediately relieved 
by the administration of our Dialysed Iron, and ultimately recovered. 
Other instances, both in the United States and in Canada, have been 
reported, but the above may suffice for reference. Soluble Compressed Pellets. 
A NEW FORM OF REMEDIES FOR HYPODERMIC USE. 
By H. AUGUSTUS WILSON, M. D., 
Ophthalmic and Aural Surgeon to St. Mary’s Hospital; Lecturer on Diseases of the Eye and Ear, and on Fracture 
Dressings at the Philadelphia School of Anatomy; Member of the Philadelphia County 
Medical Society, Northern Medical Society, etc., etc. 
Extracts from a paper read before the Philadelphia County Medical Society, Oct. 27,1880, 
Solutions for hypodermic use have been very generally abandoned 
because the penicillum, which so soon forms, renders the use of medicines 
in this form uncertain, if not dangerous. 
Because of the danger and uncertainty, as well as the inconvenience 
of carrying the medicines in solutions, the profession has resorted, where 
practicable, to the use of powders, which are carried either in the hypo- 
dermic or pocket case. 
It is as a substitute for the latter that I propose the new form of 
soluble compressed pellets, because of their convenient size and certainty 
of contents and action. I have confined my experiments to the salts of 
morphia, because it is the drug most frequently used hypodermically, and 
because I felt confident that if I could succeed with this drug it would be 
but a simple matter to place in the same form other remedies, such as 
strychnia, arsenic, apomorphia, etc. 
The result of my first attempt to obtain a soluble pill I now show you. 
Besides the morphia, it contains one-quarter grain of white sugar; but the 
moisture necessary to roll the pills rendered them difficult to dissolve when 
required. Then the compressed form was tried with sugar; but the smart- 
ing, burning pain which immediately ensued led me to believe that the 
sugar was an irritant to the tissues, and, instead of aiding, really interfered 
with the process: therefore sodium chloride was substituted, which I found 
had not the disadvantages of sugar and possessed merits of its own. 
% The use of the sodium chloride will be apparent when I say that if 
morphia salts are compressed alone they become extremely hard and very 
slowly soluble. Hence the necessity of mixing thoroughly, before com- 
pression, some material which at the same time shall give increased bulk, 
be inert, and have a great affinity for water. The sodium chloride acts as a 
disintegrator, for upon coming in contact with water it readily dissolves 
and leaves the morphia in a fine state of subdivision, ready to be acted 
upon by water. The sodium chloride, instead of causing pain or irritation, 
seems really to assist in promoting absorption. To accomplish the solution 
usually requires not more than thirty seconds, and may be brought about 
as follows: The syringe is charged with about twenty minims of water, 
(17; 18 
Soluble Compressed Pellets. 
which is poured into a teaspoon or other convenient receptacle; the 
pellet, being dropped in, is crushed with the end of the syringe, to which 
the needle fits, and after all the lumps are broken the solution is drawn 
up and forced out three or four times, when usually the whole mass will 
be entirely dissolved and ready for use. 
It is well known that the addition of atropia sulphate greatly increases 
the hypnotic and anodyne properties of morphia salts and decreases the 
tendency to after-headache and constipation. I have, therefore, used this 
combination in all my experiments, and would suggest the following 
formula : 
R Morphiae hydrochloratis, gr. .015 
Atropiae sulphatis, gr. .0004 
Sodii chloridi, gr. J, .015 
Mix and make into compressed pill No. 1. 
I claim that the advantages of this method over any other known are: 
1st. The convenient size of the pellets. 
2d. That they may be used by the mouth, if desirable. 
3d. Their certainty of contents and dose. 
lf.th. Their certainty and rapidity of action. 
Those who have used the hypodermic method, and have often experi- 
enced the disadvantages of solutions and the inconveniences of powders, 
from their increased bulk and from the difficulty of removing all the 
powder from the paper, will, I trust, accept this my suggestion, and from 
actual use decide whether it is or is not an improvement upon existing 
methods. 
Note.—Since I called the attention of the profession, in October, 
1880, to this form of remedies for hypodermic medication, Messrs. John 
Wyeth & Brother have experimented with reference to the employment 
of the Sulphate Salts of Morphia, Atropia, Strychnia, etc., and to that 
end, at the suggestion of Prof. Roberts Bartholow, have substituted as a 
disintegrator the Sulphate for the Chloride of Sodium. I consider the 
change a good one, in view of the fact that physicians as a rule are more 
familiar with the administrations of the Sulphate Salts. 
The employment of the pellets for hypodermic use, during the past 
nine months, has convinced me that their careful use will tend still further 
to banish from our armamentarium the bulky changeable solutions, and 
the equally inconvenient powders, in preference for the soluble pellets 
to which I have had the honor of calling the attention of the medical 
profession. 
H. AUGUSTUS WILSON, M. D., 
331 South Twelfth Street, Philadelphia, 
April 1st, 1SS1, COMPRESSED 
Soluble Hypodermic Tablets. 
We have recently given much attention to the preparation of Soluble 
Compressed Tablets, to be used in hypodermic medication. This idea 
was brought to the notice of the medical profession by H. Augustus 
Wilson, M. D., of this city, in a paper read before the Philadelphia 
County Medical Society. His views were based upon carefully made 
experiments and were received with much interest. At his instance we 
undertook to prepare in this manner a number of combinations, which 
have, upon trial, proved eminently satisfactory. We therefore feel war- 
ranted in offering these articles to the profession as superior in several 
respects to all other forms for hypodermic purposes. 
They are convenient, both to carry and to use; they are accurate, 
enabling the physician to administer precisely the dose desired ; and they 
are not liable to change by keeping. Solutions are bulky, the bottles are 
apt to break or to leak, and the liquid often becomes decomposed or 
deteriorated by time. Powders become inert from atmospheric influences; 
the papers become torn and part of the medicament is often lost in the 
necessary handling. The patented gelatine discs are not quickly soluble, 
and are sometimes slow in taking effect. Their use is apt to be followed 
by abcesses, which is rarely the case with crystalloid substances. 
An extensive experience of many years in the manufacture of com- 
pressed powders (or pills), and the precision and accuracy of our mechani- 
cal appliances, enable us to make these articles with a degree of perfection 
not attainable in any other way or by any other process. The exact 
amount specified of each drug is thoroughly incorporated and distributed 
throughout every tablet. In water at ordinary temperatures a perfect 
solution may be made in from thirty to sixty seconds. 
No extraneous material is employed except the Sulphate of Sodium, 
and this only in such proportions as to facilitate solution. 
CAUTION.—The dose of Morphia for hypodermic use varies from 
T\ to ]/2 of a grain. We would suggest to the profession the necessity 
for caution, the large doses sometimes recommended—y2, and even 
1 grain—are unsafe for the first trial, unless the conditions requiring the 
injection be exceptional. In commencing, it should not exceed one-third 
of that ordinarily administered internally. 
DIRECTIONS.—The syringe is charged with about twenty minims 
of water, which is poured into a teaspoon or other convenient receptacle; 
the pellet being dropped in, is crushed with the end of the syringe, to 
which the needle fits, and after all the lumps are broken the solution is 
drawn up and forced out three or four times, when usually the whole mass 
will be entirely dissolved and ready for use. 
If warm water is used, or the spoon is heated over a lamp or gas jet, 
a perfect solution is effected in a moment. The Tablets may be readily 
powdered with the blade of a knife, and a solution is even more speedily 
made in this way. 
JOHN WYETH & BRO., 
Philadelphia. 
(19) SOLUBLE COMPRESSED 
HYPODERMIC TABLETS. 
The following formula and combinations embrace all those in general 
request. Others will be added as the demands of the profession warrant 
their manufacture. 
We claim for our Hypodermic Tablets : 
Absolute accuracy of dose. 
Ready and entire solubility. 
Perfect preservation of the drug. 
Their convenience and utility will at once be apparent on examination. 
Morphi® Sulphas, 1-2 grain, 
Sod® Sulphas, 1-4 grain. 
Morphi® Sulphas, 1-3 grain, 
Sod® Sulphas, 1-4 grain. 
Morphi® Sulphas, 1-4 grain, 
Sod® Sulphas, 1-4 grain. 
Morphi® Sulphas, 1-6 grain, 
Sod® Sulphas, 1-4 grain. 
Morphi® Sulphas, 1-8 grain, 
Sod® Sulphas, 1-4 grain. 
Morphi® Sulphas, 1-12 grain, 
Sod® Sulphas, 1-4 grain. 
Morphi® Sulphas, 1-2 grain, 
Atropi® Sulphas, 1-100 grain, 
Sod® Sulphas, 1-4 grain. 
Morphi® Sulphas, 1-3 grain, 
Atropi® Sulphas, 1-120 grain, 
Sod® Sulphas, 1-4 grain. 
Morphi® Sulphas, 1-4 grain, 
Atropi® Sulphas, 1-150 grain, 
Sod® Sulphas, 1-4 grain. 
Morphi® Sulphas, 1-6 grain, 
Atropi* Sulphas, 1-180 grain, 
Sodas Sulphas, 1-4 grain. 
Morphi® Sulphas, 1-8 grain, 
Atropi® Sulphas, 1-200 grain, 
Sod® Sulphas, 1-4 grain. 
Morphi® Sulphas, 1-12 grain, 
Atropi® Sulphas, 1-250 grain, 
Sod® Sulphas, 1-4 grain. 
Atropi® Sulphas, 1-60 grain, 
Sod® Sulphas, 1-4 grain. 
Atropi® Sulphas, 1-100 grain, 
Sod® Sulphas, 1-4 grain. 
Atropi® Sulphas, 1-150 grain, 
Sod® Sulphas, 1-4 grain. 
Strychni® Sulphas, 1-60 grain, 
Sod® Sulphas, 1-4 grain. 
Strychni® Sulphas, 1-100 grain, 
Sod® Sulphas, 1-4 grain. 
Strychni® Sulphas, 1-150 grain, 
Sod® Sulphas, 1-4 grain. 
We are under many obligations to Professor Roberts Bartholow, 
who, from his thorough scientific investigations and extensive experience 
in hypodermic medication, is recognized as the highest authority on the 
subcutaneous treatment of disease, for suggestions and advice in regard to 
the care required in preparing our Hypodermic Tablets; also for the 
kind interest in devising the above formulae. 
His book on “Hypodermic Medication ” is well known as the standard 
work on that subject, and has reached a third edition. 
The success of our efforts to furnish the medical profession a much 
needed improvement in hypodermic medication is due to the happy 
suggestion of Dr. H. Augustus Wilson, and to the kind interest of other 
medical friends, who have advised us as to the absolute essentials in pre- 
paring so delicate and important a series of medicaments. 
JOHN WYETH & BROTHER, 
1412 & 1414 Walnut St., Philada. 
(20)