PROJECT REPORT 
COMMITTEE ON FOOD RESEARCH 
QUARTERMASTER FOOD AND CONTAINER INSTITUTE 
FOR THE ARMED FORCES 
CHICAGO ILLINOIS 
RESEARCH AND DEVELOPMENT BRANCH 
MILITARY PLANNING DIVISION 
OFFICE OF THE 
QUARTERMASTER GENERAL 
COOPERATING INSTITUTION 
The Mount SindL Hospital 
LOCAL I TY 
1 East IOC street, flew lark 29, fl.I. 
D I VI SI ON 
Laboratories 
OEP ARTM ENT 
Gastroenterology Research Laboratory 
OFFI Cl AL I N VESTI GATOR 
Dr. Franklin Hollander 
“IVrKrt A. Kcber 
i>r. Joseph Bahces 
REPORT NO. 
7 
FILE NO. 
P-1009 
contract' no. 
Wll-009 qm-70204 
FOR PERIOD COVERI NG 
July 1-November 1, 1947 
INITIATION DATE 
1 July 1346 
TITLE: P] PROGRESS REPORT [ j PHASE REPORT [ \ 
rIePOT^'T—JtERMI NATION REPORT 
"Studies on the Physiology of Voluntary-■''Food . 
SUMMARY 
LlDnnru jr 
At the 55th v?eek cf stu y, F.X.’s jejunai rsi£jke cf aliment was 
’educed from 4000 to 2000 1 ./da jr, and it raj kept tfiislevei for 5 eeks. 
during this period, his mean oral caloric intake decreased from a previous 10 
'reek value of circa 11,000 Cal./, .ay to about 7000 Cal./aay, and his mean • eight 
dropped from 112 to 105.8 lbs. Jejunal elimentation a._ then rciseu to 5000 
Oal./uay for 4 reeks, curing yhich. time there ras a further arc;; in weight to 
..02 lbs. ana an increase in oral intake cc 15,000 Cal./-ay. Fo .loving this, 
F.Z. * as allowed a S-- eek vacation an..r he vt.s guppiieu with Aliment for self- 
jidministraticn at a level of 4000 Cal./lay. during this pericc. his crrl intake 
pumped to an average value of 20,000 On his return to the Laboratory, 
at the end of the vacation, his "eight 1 .s 03.5 ibj. (average for one veek). In 
lie subsequent 4 veeks, on e jejunal intake cf 4000 Cal./lay, bis reight rose 
only to 09.7 lbs. '-hile his oral intake remained in the neighborhood of 20,000 
Oai./aay. The Aliment vas then supplemented by the audition of Z0 fc.. of »hole 
liver Substance per day. This ’■as accompanies. by .-xa increase in bony ••’eight to 
a peak value cf 104.5 lbs. a -mean cf 105.9 Ids. (for the second • eek). The 
average oral caloric intake recorded for this leriou -.as 34,000 Cal./day. 
In general, these date, indicate an increase in oral intake a.asc civ ted ith 
u.n increase in jejunal intake. This result is contrary to expectation from 
gener 1 experience. Also, cur earlier observations inaic- tea that augmented 
, ejunal intake re ;uited in a decreased oral intake. On the other ham, during 
the current period the body weight dropped 1 ijth^Te^e-asejS^qua• \L intake, but then 
continued to fail in spite cf the c: ydunl calories. 
Only after liver as added to the Aliment' v xs tpera 'n% increase in 
ireight — 4.2 lbs. in 2 veeks — in spitjb cf a const'-nt jejunal iiitake. The oral 
intake also rose by 4000 Cal., but the significance d:. ©is increase is uncertain 
because-of the short period (2 -veeks) cf Observation, luring thk first 2 veeks 
of the first test aitfa liver supplement, F^i^1 d-^-eightr :nd his oral 
intake increased at least tso-fold. — , 
Starting with the early summer, the -ubject become increasingly unc -r.er -rivi> 
< s a result of several factors: late adolescence, anxiety over his v eight loos, 
r.ews oarer resorts of miraculous cures "of1 ether inaiviliels .Ith esorhameal 
l2-,2‘ 
certified obstruction, end above all social pressure to Mao something about his condition." 
In fact there rere many signs of a desire for immediate relief — even by 
surgery 1 hich had previously been rejectee. Finally on October 10, he 
abruptly left the Laboratory in the mid le of the day* ostensibly on impulse. 
A fe:- days later ve ’-ere informed by his mother that they were seeking therapy 
at another hospital, but might return to the Laboratory if they vere unsuccess- 
ful. In vie:-* of the variability of response to a repetition of experimental 
cor iltions, and the impossibility of controlling the emotional factors 
involved, it is our tentative ccncinsion, that my physiological variables 
affecting oral intake in the present study v/ere subordinate to the psychic 
influences. 
-1009 #7