The Therapeutical Applications 
OF 
Peroxide of Hydrogen 
(MEDICINAL), 
and Glycozone 
BY 
CHARLES MARCHAND, Chemist, 
GRADUATE OF THE " ECOLE CENTRALE DES ARTS ET MANUFACTURES 
DE PARIS" (FRANCE). 
TREATMENT OE DISEASES CAUSED 
BY 
GERMS, BACTERIA, MICROBES. 
FIFTH EDITION. 
NEW YORK 
1893. Copyright 1893, by Charles Marchand TO THE MEDICAL PROFESSION. 
I respectfully call attention to the fact, that I am the sole manu- 
facturer of Peroxide of Hydrogen (Medicinal). 
The commercial article is good enough for bleaching purposes, but 
totally unfit, unsafe, and always worthless to use as a remedy. 
The low price of this commercial article (which we sell in bulk at 
five cents per pound) explains why unscrupulous druggists are base 
enough to place the reputation of the physician, as well as the life of 
his patient, in jeopardy, by substituting worthless imitations, by which 
they pocket a profit varying from 500 to 1000 per cent. 
In fact, the substitution of the commercial for the Medicinal Peroxide, 
is calculated to work serious injury and destroy the physician's con- 
fidence in this most potent remedy. 
The unsolicited articles, written by contributors to the medical lit- 
erature and published by medical journals, prove that Marchand's 
Peroxide of Hydrogen (Medicinal) is the only reliable preparation for 
its uniformity in strength, purity and stability, and also for its healing 
and bactericide properties, which are considerably increased to the 
detriment of its bleaching properties. 
The virtues of Charles Marchand's Peroxide of Hydrogen (Medic- 
inal) are due to the special process by which it is prepared, and it 
retains its germicide and curative power for any length of time when 
kept with ordinary care. In order to protect the Profession from fraud, Marchand's Peroxide 
of Hydrogen (Medicinal) is sold only in i-lb., 8-oz. and 4-oz. bottles, 
bearing a blue label, white letters, red and gold border with his sig- 
nature; never sold in bulk. 
By specifying in your prescriptions Ch. Marchand's Peroxide of 
Hydrogen (Medicinal), original package, you will never be imposed 
upon. 
Glycozone is sold only in 1 -lb., 8-oz. and 4-oz. bottles, bearing a 
yellow label, white and black letters, red and blue border, with his 
signature; never sold in bulk. 
Insist upon getting these wonderful remedies in their original pack- 
ages and you will never be disappointed. 
Yours very respectfully, 
Chemist and Graduate of the "Ecole Centrale des Arts et 
Manufactures de Paris" {France.) CONTENTS. 
Page 
Alveolar Abscess and Abscess of the 
Inferior Maxilla-Treatment 38 
Abscess of the Vagina-Treatment. .. 34 
Action of Ch. Marchand's Peroxide of 
Hydrogen (medicinal) upon animal 
and vegetable cells 5 
Action of Ch. Marchand's Peroxide of 
Hydrogen (medicinal) upon infected 
surfaces 7 
Anthrax-Carbuncle-Treatment 32 
Asthma-Treatment by Ozonized Va- 
por Inhalations 20 
Bronchitis-Treatment 20 
Catarrh of the Nose and Catarrh of 
the Throat-Treatment 10 
Catarrhal Conjunctivitis or Ophthalmia 
-Causes-Treatment 40-41 
Caution-How to cleanse the curved 
spray tube of Marchand's Hand 
Atomizer and Ozonizer 20 
Comparative chemical reactions be- 
■ tween Marchand's Peroxide of Hy- 
drogen (medicinal) and Ozone 4 
Cholera-Treatment 44 
Consumption-Phthisis - Causes; Ba- 
cillus Tuberculosis-Treatment by 
Ozonized Vapor Inhalations 23 
Croup-Membraneous Croup-Causes 
-Treatment 25 
Definition of Pathogenic Micro-Organ- 
isms, according to Prof. Koch 1 
Destructive Action of Ozone Upon 
Virus 3 
Diphtheria-Cause-Treatment 26 
Directions for Using Marchand's Hand 
Atomizer and Ozonizer 17 
Diseases Caused bv Germs or Microbes 2 
Page 
Dyspepsia--Causes--Treatment by 
Glycozone 27 
Epidemies are Caused by Absence of 
Ozone in the Atmosphere 3 
Fistula (Recto-Vaginal)-Treatment.. 35 
Gastritis-Catarrh of the Stomach- 
Causes-Treatment 29 
Gonorrhoea-Gleet-Treatment 35 
Glycozone-Important Information... 46 
Hay-Fever-Rose Cold-Coryza- 
Causes-Treatment 13 
How to Use Marchand's Peroxide of 
Hydrogen (medicinal) in Acute Ca- 
tarrh of the Nose 16 
Important Information on Peroxide of 
Hydrogen 5 
Inflammatory Diseases of the Eyes- 
Treatment 40 
Inflammatory Diseases of the Bladder 
-Treatment 42 
Influenza-LaGrippe-Causes-T reat- 
ment of the Local Symptoms 15 
Inhalation of Oxygen and the so-called 
"Compound Oxygen" Treatment, 
(foot note) Opinion of Karl Von 
Ruck, B. S., M. D 7 
Laceration, Inflammation and Ulcera- 
tion of the Gums-Stomatitis- 
Treatment 39 
Laryngitis-Treatment 25 
List of Diseases Successfully Treated 
by Marchand's Peroxide of Hydrogen 
(medicinal) and by Glycozone 36 
List of Antiseptics-Their relative bac- 
tericide power 8 CONTENTS (Continued). 
Page 
Suppurative Diseases of the Ear- 
Treatment 42 
The Dangers of Carbolic Acid-Re- 
sults of Experiments, (foot note) 9 
Testing Process for Peroxide of Hy- 
drogen 6 
The Use of Marchand's Peroxide of 
Hydrogen (medicinal) in Dental 
Surgery 37 
T yphoid Fever Causes T reat- 
ment 3I-32 
Typhus-Treatment 44 
Ulcer of the Stomach-Causes-Treat- 
ment 29-30 
Whooping-Cough-Causes-Treatment 
21-22 
Women's Weaknesses-Whites, Leu- 
corrhoea, etc. -Treatment 3 3-34 
Yellow Fever-Causes-Treatment... 33 
Page 
Marchand's Hand Atomizer and Ozoni- 
zer-Description 17 
Marchand's Hand Atomizer and Ozoni- 
zer-Cuts 18-19 
Necrosis and Caries of the Teeth- 
Treatment 39 
Opinion of the Medical Profession- 
Reprint of Articles by Contributors 
to the Medical Literature 48-95 
Ozcena-Treatment 12 
Pharyngitis-Treatment 25 
Purulent Conjunctivitis or Ophthalmia 
in Children-Treatment 41 
Relations of Bacteria to Disease 1 
Scarlet Fever-Causes-Treatment. 30-31 
Sore Throat-Quinsy-Tonsilitis and 
all Inflammatory Diseases of the 
Throat-Treatment 24 RELATIONS 
OF 
BACTERIA TO DISEASE. 
The branch of science named Bacteriology was opened to the 
medical profession by the classical researches of Prof. Pasteur in the 
settlement of the question of spontaneous generation, and in his sub- 
sequent studies of the process of fermentation. With the investigations 
of that distinguished French savant began our first positive knowledge 
of the definite relations of bacteria to disease in the animal kingdom. 
Prof. Robert Koch, of Berlin, has contributed widely by his experi- 
ments to the progress in knowledge of the etiology of infectious and 
contagious diseases. 
Owing to the methods which he has devised in order to practically 
and easily isolate different species of bacteria, we are now enabled to 
follow the phases of their development in pure cultures, under varying 
circumstances. 
Microscopical examinations show that, during the various stages of 
their life, bacteria present different forms and dimensions ; but it is also 
demonstrated that one species of bacteria, placed under the same circum- 
stances, always present the same forms, and produce the same effects. 
Bacteria are principally constituted by an albuminoid substance, 
called microproteine. 
The pathogenic bacteria only are of the greatest interest to the 
physician, and, according to the definition given by Prof. Koch, a micro- 
organism is pathogenic when it presents the following characteristics : 
First-It must be found in the excretions, secretions, or tissues of 
the animal suffering or dead from the disease. 
Second-The micro-organism must be cultivated out from the 
organism. 
Third-A pure culture inoculated in an animal should reproduce 
the disease. 2 
Fourth-The bacteria should be found in the humors or tissues of 
the animal after death. 
Pathogenic bacteria are differently affected in their infective power 
by the soil in which they grow ; some of them have a limited or local 
action, and others produce the infection of the whole system with a 
prodigious rapidity. 
These facts have been demonstrated from microscopical examina- 
tions ; for example, the autopsy shows that the blood of a patient who 
died from Diphtheria is invaded with a large number of microbes called 
micrococci, the same microbes being detected also in the diphtheritic 
membrane, which was at first the seat of this infectious disease. 
The microscopical examination of the blood of a patient who died 
from Anthrax shows the presence of the Bacillus Anthracis, which was 
at first found only in the excretions or pus coming from the infected 
surface. 
Consequently, the contagion is not always immediate. During this 
period of localization of the disease, the microbian element should be 
destroyed by a proper medication, in order to prevent its propagation 
through the whole system. 
Micro-organisms or germs in the atmosphere have been shown by 
Ehrenburg to exist in masses or clouds ; so that, in a room containing 
infection, a portion of the air may be loaded, while other portions are 
nearly free, which would seem to explain cases of escape from septic 
or zymotic influences. 
It is owing to the presence of these micro-organisms that Profs. Pas- 
teur, Koch, Tyndall, and others have been able to establish the germ 
theory of disease. 
Diseases caused by Germs or Microbes.--It is to the micro- 
organisms we are indebted for Catarrh, Ozoena, Hay Fever, Diphtheria, 
Croup, Sore Throat, Quinsy, Tonsilitis, Bronchitis, Whooping-cough, 
Laryngitis, Pharyngitis, Pneumonia, Consumption, Catarrh of the 
Stomach, Women's Weaknesses, Whites, Leucorrhcea, Typhoid Fever, 
Scarlet Fever, Measles, Small-pox, Skin Diseases, Yellow Fever, Chol- 
era, Abscesses, Carbuncle, Ulcers, Gonorrhoea, Syphilitic Sores, and 
other chronic affections. 
It is no wonder, after becoming acquainted with such facts as the 
above, that scientists have studied with such care the properties os 
antiseptics in order to destroy the germs. 3 
Destructive Action of Ozone upon the Virus.-A fact known 
by bacteriologists and chemists is that: All virus is albuminoid, 
whether propagative or not ; it is destroyed, or by coagulation rendered 
inert, by the oxidizing action of " Ozone," just as it is by contact with 
corrosive sublimate and other antiseptics. 
Then, it is evident that if some substance could be produced which 
would oxidize or destroy these micro-organisms, so as to change their 
infectious character, a great benefit would result, providing this de- 
stroyer of germs would have no injurious consequences upon the life of 
animals. 
Such a substance we have in ozone, Os; or condensed oxygen, Oa O. 
It is nature's disinfectant. 
Houzeau found the air of the country at the height of six feet above 
the ground to contain °f ^ts weight of ozone, or of its 
volume. 
This very small quantity of ozone is sufficient, owing to its wonder- 
ful oxidizing power, to destroy germs. 
" Ozone " is a normal constituent of fresh air ; its proportion varies 
with temperature and electric conditions of the atmosphere. 
Billard, Wolf, Boeckel, and Strambes agreed that the cholera, when 
it raged in Strasbourg, Berlin, and Milan, coincided with the absence of 
ozone in the atmosphere, and that ozone reappeared at the end of the 
epidemy. 
These observations are in perfect accord with those obtained by Dr. 
F. H. Hammond. Dr. Moffatt, Romain Vigouroux, Uhle, and numer- 
ous other scientists also attribute the prevalence at time of cholera, 
malarious fever, to the absence of ozone in the air. 
Is it due to an excessive production of miasms relatively to the 
normal proportion of ozone, or is it because "Ozone " is in deficiency 
to destroy these germs ? 
No one could answer this question, but the positive fact is that : 
" If Ozone is in excess, there is no epidemy." 
The wonderful antiseptic value of " Ozone " has attracted the atten- 
tion of all scientists, and a number of chemists have devised different 
methods of its production ; but no one of these processes could be 
used to manufacture ozone industrially. 
We have in Peroxide of Hydrogen, H202, a substance which is always 
on a strain to break up into water and nascent oxygen, or ozone. 4 
The fact that Peroxide of Hydrogen (medicinal) generates nascent 
oxygen (near to the condition of Ozone), when brought into con- 
tact with any infected surfaces is proved by experiments which I have 
made in order to establish the comparative chemical reactions between 
these two wonderful bactericides, and I now submit to the profession 
the results which I have obtained. 
COMPARATIVE CHEMICAL REACTIONS BETWEEN MARCHAND'S PEROXIDE 
OF HYDROGEN (MEDICINAL), H2O2, AND OZONE (FORMULA O3), 
Iodide of Potassium So- 
lution in presence of 
H2 O2 Solution. 
Ozone. 
Result 
of reaction: 
Potash and Iodine. 
Result 
of reaction: 
Potash and Iodine. 
Immediate discoloration. 
Escaping of Oxygen 
Gas and formation of 
brown Oxide of Man- 
ganese. 
Permanganate of Potash 
Purple Solution in pres- 
ence of 
II2 O2 Acidulat- 
ed Solution. 
Result 
of reaction: 
K2 Mn2 O84"4 U2 O2-2 RHO-|-Mn2 Hg Og-|~4O2 
Peroxide of Iron Salt So- 
lution and Ferricya- 
nide of Potassium So- 
lution mixed together 
in presence of 
Ozone. 
Result 
of reaction: 
Ferricyanide is trans- 
formed into Ferrocya- 
nide of Potassium, giv- 
ing a blue coloration. 
H2 O2 Solution. 
Ozone. 
Result 
of reaction. 
Same result. 
Tincture of Indigo in 
presence of 
H2 O2 Solution. 
Ozone. 
Result 
of reaction: 
Decoloration. 
Result 
of reaction: 
Decoloration. 
Nitrous acid in presence 
of 
II2 O2 Solution. 
Ozone 
Result 
of reaction: 
Formation of Nitric 
Acid. 
Result 
of reaction; 
Result 
of reaction: 
Same result. 
Arsenious Acid in pres- 
ence of 
H2 O2 Solution. 
Ozone. 
Result 
of reaction: 
Formation of Arsenic 
Acid. 
Same result. 
Blue coloration, with ef- 
fervescence and coagu- 
lation of albumen. 
Tincture of Guaiacum 
mixed with either 
Blood or extract of 
Malt. 
H2 O2 Solution. 
Ozone. 
Result 
of reaction: 
Result 
of reaction: 
Same reaction. 
Organic substances such 
as Cotton, Woolen, 
Silk, Feathers, Hair, 
Bones, Ivory, etc., in 
presence of 
H3 O2 Alkaline 
Solution. 
Ozone. 
Result 
of reaction. 
Oxidizing and Bleaching 
Action. 
Same result but slower 
action. 5 
IMPORTANT INFORMATION ON PEROXIDE OF 
HYDROGEN. 
Pure anhydrous Peroxide of Hydrogen yields four hundred and 
seventy-five volumes of oxygen; that is, it gives off four hundred and 
seventy-five times its own volume of oxygen. It is a very unstable 
liquid compound, having by itself a slight acid reaction to the litmus 
paper. Its decomposition into water and oxygen takes place under the 
most enigmatical influences. Hence it is not an article of commerce. 
Charles Marchand's Peroxide of Hydrogen (medicinal) is really a 3^ per 
cent, solution of the anhydrous peroxide in water; 1 per cent, solution 
yields 4.75 times its own volume of oxygen. Consequently, the Per- 
oxide of Hydrogen (medicinal) which I manufacture yields "3^ times 
4.75" its own volume of oxygen; viz., a trifle more than fifteen times 
its own volume of oxygen gas. It is called a 15-volume solution. 
Owing to the unstableness of this compound, my medicinalprepara- 
tion is acidulated with traces of hydrochloric acid and traces of phos- 
phoric acid. The acid is indispensable in order to preserve the solution 
from rapid decomposition, and it is unnecessary to neutralize these 
traces of acid, before use, even in the most delicate cases. 
All injurious chemicals are eliminated from Charles Marchand's 
Peroxide of Hydrogen (medicinal). It is a colorless, almost tasteless, 
and odorless fluid. The special process by which it is prepared, con- 
siderably increases its healing and bacteride power, to the detriment 
of its bleaching properties. It is uniform in strength, purity and 
stability; being kept in a cool place, such as a cool cellar, it retains its- 
germicide power for any length of time. 
Action of Charles Marchand's Peroxide of Hydrogen (medic- 
inal) upon Animal Cells and Vegetable Cells.-See report by 
Dr. Paul Gibier, page 56; also report by Dr. S. Potts Eagleton, page 
68. Experiments made by Bacteriologists prove beyond doubt that: 
1st. Charles Marchand's Peroxide of Hydrogen (medicinal) has 
no injurious effect upon animal cells. 
2d. It has a very energetic destructive action upon vegetable 
cells-microbes. 
3d. It has no toxic properties; five cubic centimetres injected 6 
beneath the skin of a guinea pig does not produce any serious result, 
and it is also harmless when administered internally. 
4th. It is a stimulant to granulating tissues. 
5th. It has no corrosive action whatever upon the healthy mucous 
membranes when applied to the treatment of diseases caused by 
germs, such as Diphtheria, Scarlet Fever, Whooping Cough, etc. 
6th. It is the pus destroyer "par excellence." See article headed 
■"The Necessary Peroxide of Hydrogen," by Dr. Robert T. Morris, 
page 55. 
Testing Process.-The testing process which is often followed by 
-chemists is based upon the following reaction which is accompanied 
by discoloration of the Permanganate of Potash solution (K2 Mn8 O8.) 
(No. 1.) 5H2O2+K2Mn2O8+3H2SO4=K2SO44- 2MnSO4+8H2O+10O 
Experiments made by Prof. Weltzien, Schoene, and Hamel, show 
that the chemical reaction which takes place is expressed by the fol- 
lowing equation: 
(No. 2.) K2 Mn2 O8 + 4 H2 O2=2 KHO -|- Mn2 H6 O6 4- 4 O2. 
According to reaction No. 1, half of the Oxygen liberated comes 
from the decomposition of K2 Mn2 O8, and the other half comes 
from H2O2. On the contrary, according to reaction No. 2, the total 
amount of Oxygen which is set free, comes from H2 O2 alone. 
Prof. Hamel tests the Peroxide of Hydrogen (according to equation 
No. 2) with a standard solution of Permanganate, and he measures the 
volume of oxygen resulting from the decomposition of H2 O2. (See 
Ad. Wurtz Diet, of Chemistry, Supplement p. 674.) This Oxygen 
represents the totality of the Oxygen contained in H2 O2. Instead of 
decomposing H2 O2 with the Permanganate, the same result may be 
obtained by using Oxide of Silver (Ag2O) as expressed by the fol- 
lowing equation: 
(No. 3.) Ag, (O+H.) O^Ag,+H, O+O,. 
I abandoned the testing process based upon the reaction No. 1 be- 
cause it implies that the oxygen contained in Hg O2 is not "Con- 
densed Oxygen," but "Oxygen" in its inactive state. This assertion 
is wrong, otherwise the reaction expressed by the following equation: 
(No. 4.) 5Hs (04-0) +KS Mn2 OS4-3H2 SO4=K2 SO4-|-2Mn SO.H-8H2O-|-10O. 
would take place in the same conditions as the reaction No. 1, and 
such is not the case. 7 
The results of my experiments, published on page 4, prove that 
oxygen exists in peroxide of hydrogen in its allotropic state, near to 
the condition of "ozone" or "condensed oxygen." 
Action of Charles Marchand's Peroxide of Hydrogen upon 
Infected Surfaces.-When Peroxide of Hydrogen (medicinal) is 
brought into contact with any diseased surface, either of the skin or of 
the mucous membranes, its decomposition takes place immediately,, 
and at first "ozone," which is the result of this reaction, coagulates the 
albuminoid matters of the secretions, the pus is destroyed, and also 
the bacteria. As soon as "ozone" has accomplished its cleansing 
effects upon the infected surface, it is readily transformed into ordi- 
nary oxygen, owing to its instability. 
It is of great importance to notice that water, charged with fifteen 
times its own volume of oxygen gas (formula O) under pressure, has 
no similar action whatever on the albuminoid substances, as there is. 
no coagulation, and no cleansing effects upon the unhealthy secretions 
of the infected surfaces. 
This remark was necessary in order to establish plainly the differ- 
ence between the therapeutical value of Peroxide of Hydrogen and 
the Oxygen or the Compound Oxygen treatments.* 
Although Ch. Marchand's Peroxide of Hydrogen (medicinal) is rec- 
ognized by leading physicians (see the opinions of the medical profes- 
* Concerning the so-called "Compound Oxygen treatment," I shall refer the profession to a very 
elaborate report on: 
"The Management of Pulmonary Diseases," by Karl von Ruck, B. S., M. D., Director of the Win- 
yah Sanitarium for Diseases of the Throat and Lungs. Ashville, N. C., 1889. On pages 8 and 9 of 
this publication, the author writes as follows: 
"Inhalation of Oxygen.-Undoubtedly some benefit has been derived from such inhalations in 
anaemia and digestive derangements, also in certain forms of dyspnoea I have seen patients made much 
more comfortable after each inhalation, especially when a small quantity of nitrous oxide was added. 
I have also seen an occasional but undoubted increase in the number of red blood-corpuscles under its- 
administration, both in essential and symptomatic ansemia, especially when iron preparations, which 
alone had proved inefficacious, could be administered at the same time. Its range of usefulness in con- 
sumption is secondary altogether to many other means, and it is only occasionally that anything more 
than temporary relief can thereby be given, and, no matter how plausible the theory as to its influence 
upon nutrition, practical experience shows that its use is always experimental, and frequently without 
result, the same as is the case in its employment in other diseases. Its mixture with nitrous oxide, in 
the form of the so-called 'compound oxygen,' by the temporary stimulating or intoxicating effect of the 
laughing gas, has no advantage whatever, except in dyspnoea, but it makes the patients who be- 
come the victims of charlatans feel that 'something powerful' is present in .such inhalations, and 
induces them to believe in it the more readily. This 'compound oxygen cure for consumption' still 
flourishes in many localities, the same as do the quack remedies for the same object upon the 
shelves and counters of our druggists, and I have no doubt the venders of such with their adver- 8 
sion on page 48) as being the most powerful and reliable antiseptic known, 
I now beg to submit to the profession the results of comparative tests 
which I have made, in order to demonstrate experimentally the differ- 
ence between the bactericide potency of the following chemicals, acting 
upon a diphtheritic membrane for the destruction of microbes present 
in half a gramme of the said membrane. 
Mixture or solution containing 3^ per cent, of the following 
chemicals : 
QUANTITY OF THE MIXTURE OR SOLUTION REQUIRED TO 
ANNIHILATE MICROBES. 
Cubic Centimetres 
Glycozone (harmless) 0.75 
Biniodide of mercury 1.00 
Biniodide of silver 1.33 
Marchand's Peroxide of Hydrogen, medicinal (harmless) 2.00 
Bichloride of mercury 3.00 
Nitrate of silver 5.00 
Hypochlorite of lime 9.00 
Chlorine gas (aqueous solution) 10.00 
Iodine 10.00 
Bromine 24.00 
Iodoform (when fresh) 28.00 
Salicylic acid 40.00 
Muriatic acid 100.00 
Carbolic acid 128.00 
Permanganate of potash 140.00 
Chlorate of potash 158.00 
Alum 180.00 
Tannin 190.00 
Common salt 196.00 
Sulphide of calcium 201.00 
Boracic acid 300.00 
Sulphurous acid 325.00 
Lactic acid 360.00 
Chloride of iron 371.00 
Thymol, eucalyptus, bicarbonate of soda, lime-water, turpentine, 
have no action at all upon the microbes of a diphtheritic membrane 
tisements, are as injurious parasites upon the consumptives as are the tubercle bacilli themselves ; 
and while we must acknowledge that our efforts in phthiso-therapy against the latter have thus 
far been unavailing, many lives could undoubtedly be saved if the former could be extinguished by 
the enactment of wise laws which would oblige them to derive their means of livelihood otherwise 
than by trifling with human life." 9 
when they are developed ; but they may have, to a certain extent, a 
preventive action upon the development of the spores. 
The permanganate of potash, hypochlorite of lime, bichloride of 
mercury, the aqueous solution of chlorine gas, carbolic acid, nitrate of 
silver, etc., destroy the microbes ; but, being poisonous, they have the 
most dangerous effect upon the patient's life. 
It is worthy of note that the medicinal preparations made by 
Charles Marchand, viz., Glycozone and Peroxide of Hydrogen (medi- 
cinal), are absolutely harmless. All other chemicals have toxicant, cor- 
rosive, or poisonous properties, as is proved by chemical tests ; and 
their use is, in many instances, more dangerous than the disease itself. 
By referring to the comparative tests published on page 8, it is 
easy to notice that Charles Marchand's Peroxide of Hydrogen (medic- 
inal), as a bactericide, is times as strong as. bichloride of mer- 
cury, 2^ times as strong as nitrate of silver, 5 times as strong as 
iodine, 14 times as strong as iodoform, 20 times as strong as salicylic 
acid, 64 times as strong as carbolic acid.* 
* The Dangers of Carbolic A cid.-The following experiments which I have made prove beyond 
doubt the dangers of applying carbolic acid in the treatment of suppurative diseases. 
Six dogs were submitted to the action of this corrosive antiseptic in the following manner: 
Two to three square inches of hair on the leg of each animal upon which the experimentation 
took place was closely shaved. 
Morning and evening an application, from 8 to io drops (three per cent, solution) of carbolic 
acid was made upon these prepared surfaces and continued for ten days. 
One hour or so after each application the surface was dry, owing to the evaporation of water, 
and then, as an immediate consequence, it was covered by a small quantity of pure, concentrated 
carbolic acid, of which the corrosive properties are well known. 
At the expiration of said time two of these dogs were sick, each one having an ulcer on the 
prepared surface of the leg, which was due to the repeated application and evaporation of the 
three per cent, solution of carbolic acid ; and three days later each one of the four other dogs had 
an ulcer of the same nature, which was produced from the same cause. 
These four dogs were then submitted to treatment by my Peroxide of Hydrogen, which in four 
weeks thoroughly cured them. 
The application of the three per cent, solution of carbolic acid on the ulcers of the two other 
dogs was again continued, and on the fiftieth and sixty-second day, respectively, both animals 
expired from blood-poisoning. The autopsy showed that ihe blood of these animals was invaded 
by the bacteria of Davaine, which were detected by a microscopical examination. GENERAL DIRECTIONS FOR APPLYING 
CH. MARCHAND'S PEROXIDE OF HYDROGEN 
(MEDICINAL), H>0., 
IN THE TREATMENT OF DISEASES CAUSED BY GERMS. 
NOSE.-THROAT AND CHEST DISEASES.-TREATMENT. 
CA TARRH OF THE NOSE AND CA TARRH OF THE TH ROA T. 
Causes.-Micro-organisms, principally of the micrococcus species, 
have been detected by microscopical examinations, by scientific men. 
and by myself, in the mucous discharges from the nostrils of persons 
afflicted with this disease. Those germs which are the cause of the 
infection are readily destroyed by Charles Marchand's Peroxide of 
Hydrogen (medicinal), and there is no danger for the patient to use 
this remedy in any quantity, as it is positively harmless. 
Treatment.-By means of an atomizer, made of glass and hard 
rubber, spray the nose and the throat copiously and repeatedly twice 
or three times every day with a mixture of 
i tablespoonful Marchand's Peroxide of Hydrogen (medicinal), 
with 4 to io tablespoonfuls of water (cold or lukewarm), 
according to the degree of inflammation in the mucous membranes of 
the nasal cavities ; and, in case of extreme sensitiveness, use even 
a still larger proportion of water. 
Note.-In the absence of an atomizer, apply the remedy to the nose by sniffing the 
liquid from the hand through the nostrils repeatedly, and gargle the throat. It is 
always beneficial to swallow some of the remedy. 
Do not blow the nose too hard, as it might cause a temporary bleed- 
ing. 
In chronic cases of long standing, especially at the beginning of the 
treatment, when the tenderness of the mucous membrane is excessive, 11 
it often happens that the patient will feel, during one hour or so after 
each application of the remedy, a partial obstruction of either one or 
the other of the nostrils. 
This very unpleasant feeling is often accompanied by frequent 
sneezing, which is due to the tickling sensation produced in the nasa/ 
cavities by the presence of a great quantity of minute bubbles of 
" Ozone," being set free from the decomposition of Charles Mar- 
chand's Peroxide of Hydrogen coming in contact with the infected 
surface. The unhealthy secretions are destroyed by " Ozone," and 
the cleansing of the nostrils is made perfect. 
In chronic cases, when the middle ear is affected, deafness is very 
often the consequence of this disease. Then ozonized vapor inhalations 
should follow immediately the spraying of the nose and the throat, and 
should be administered by means of Charles Marchand's Hand Atom- 
izer and Ozonizer, with a mixture thoroughly made of 
half Marchand's Peroxide of Hydrogen (medicinal) 
and half chemically pure glycerine. 
Renew this mixture every three days. It is important that the above 
mixture should be made perfect by shaking the bottle well, otherwise 
the spray-tube of the apparatus might be clogged on account of the 
syrupy nature of the glycerine.* 
The profession well know that the therapeutical agents used for the 
treatment of this disease have been as follows : 
Bichloride of Mercury.-Calomel.-Sulphate of Zinc.-Sulphate of Copper. 
-Alum.-Nitrate of Silver.-Carbolic Acid.-Salicylic Acid. -Permanganate 
of Potash.-Borax.-Boracic Acid.-Subnitrate of Bismuth.-Common 
Salt.-Muriate of Ammonia.-Extract of Eucalyptus.-Thymol.-Cocaine. 
-Camphor, etc. 
* When chronic Catarrh of the Nose is very tenacious and painful, it is necessary at night, before 
retiring, to apply a few drops of Glycozone to the nostrils. Sniff it hard, as it will accelerate the 
cure. 
In many cases the incurability of Chronic Catarrh of the Nose is due to partial or complete 
obstruction of the nasal cavities, caused by some abnormal conditions of growth, differing in their 
nature. 
When such is the case, apply Marchand's Peroxide of Hydrogen, as heretofore explained, morn- 
ing and evening, and after ten or fifteen days, if the excrescence does not disappear, it will be 
necessary to have a surgical operation performed for its removal. 
A permanent cure may then be effected in a very short time. 
After the excrescence has been removed or destroyed by means of the thermo-cautery, or any 
other operation (no caustic should be used, as it will most likely destroy both taste and smell}, an 
absolute cure is certain if the Marchand Peroxide of Hydrogen treatment is earnestly followed. 12 
It is easy to understand why Marchand's Peroxide of Hydrogen 
(medicinal) will surely accomplish a permanent cure, while the above- 
mentioned bactericides can give only temporary relief, and they are 
apt to injure or destroy both taste and smell. 
First-Because Marchand's Peroxide of Hydrogen is the most 
powerful of all antiseptics yet discovered. (See page 8, " Comparative 
Tests.") 
Second-Marchand's Peroxide of Hydrogen (medicinal) is absolutely 
harmless when applied externally or administered internally. 
Third-The borax, boracic acid, subnitrate of bismuth, muriate of 
ammonia, common salt, camphor, eucalyptus, thymol, are not very 
dangerous remedies, but their bactericide properties are too limited to 
destroy the germs which are the cause of the disease. 
On the contrary, Marchand's Peroxide of Hydrogen annihilates these 
germs instantaneously, and it leaves the healthy surrounding tissues in 
their normal condition. (See " Note," page 16.) 
OZCENA, OR PUTRID CATARRH OF THE NOSE. 
In case of Ozoena, Marchand's Peroxide of Hydrogen (medicinal) 
should be applied three times daily, diluted in the following proportion : 
Mix i tablespoonful Marchand's Peroxide of Hydrogen 
with 4 to 7 tablespoonfuls of water (cold or lukewarm). 
It is only in case of extreme tenderness of the mucous membrane 
that a weaker solution should be used, as follows: Mix i tablespoonful 
of Marchand's Peroxide of Hydrogen with 7 to 10 tablespoonfuls of 
water. 
Spray the nostrils and the throat successively and copiously with this 
diluted Marchand's Peroxide of Hydrogen, or, in the absence of an 
atomizer, apply the remedy to the nose by sniffing the liquid from the 
hand through the nostrils repeatedly, and gargle the throat. 
This treatment is so powerful that the destruction of the microbian 
element takes place immediately, and the putridity which characterizes 
this peculiar and repulsive affection is arrested three or four days after 
the beginning of its application. 
The cure is ordinarily accomplished in four weeks, but in some 
instances, when the case is of a very long standing-having become 
chronic-it requires a longer time to effect an absolute cure. 13 
In case of sneezing and obstruction of the nostrils after each appli- 
cation of the remedy, see the explanations given, page xo, article 
headed " Catarrh of the Nose." * 
Marchand's Peroxide of Hydrogen (medicinal) is the most powerful 
remedy which can be used in order to subdue this most offensive and 
very repulsive disease, and it has no injurious or poisonous conse- 
quences. (See " Note," page 16.) 
HAY FEVER.-ROSE COLD.-CORYZA. 
Causes.-The microscopical examination of the unhealthy mucous 
secretions and excretions from the nostrils of Hay-fever sufferers 
demonstrated the presence of small ovoid micro-organisms, which are 
annihilated instantly when brought into contact with Marchand's Per- 
oxide of Hydrogen (medicinal). 
It is worthy of notice that the degree of susceptibility to the infectious 
action of these germs or microbes differs with different people. The 
spores and germs which cause this disease do not always find a proper 
medium for development in the mucous secretions of different people. 
The peculiarity of this disease is that any one who is afflicted with 
Hay Fever can foretell every year, almost to a certainty, the day upon 
which the disease will begin, and also the day upon which they will get 
rid of it. 
The logical explanation of this is that the conditions of life of 
afflicted people are always the same ; that is, " the circumstances and 
surroundings of their existence are absolutely alike from year to year." 
Thus the microbian causes of the trouble develop under the same in- 
fluences every year, at about the same time ; and, consequently, the 
disease begins when the atmospheric conditions become favorable for 
the development of the spores I have mentioned. These spores grow, 
under proper conditions of temperature and dampness, in the mucous 
secretions of the nostrils, the microbian affection takes place, and in- 
flammation and ulceration of the mucous membrane is the consequence. 
These micro-organisms continue their growth as long as these favor- 
able atmospheric conditions exist, and they disappear as soon as the 
temperature falls and while it remains at a lower degree. Then the 
effects disappear with their causes, and the patient gets rid of his trouble. 
* Glycozone should be applied to the nostrils morning and evening, in order to accelerate the 
cure. 14 
Treatment.-The causes of Hay Fever being now well established, 
it is easy to understand that any remedy having the property to destroy 
microbes or germs will surely prevent or cure the disease by removing 
the cause, providing this antiseptic remedy will have no injurious 
effects upon the surrounding healthy tissues. 
In case of Hay Fever, the remedy should be applied locally to the 
nostrils as a spray, and also by inhalations, in order to subdue the 
asthmatic attacks which accompany this very troublesome complaint. 
It has been demonstrated that among the list of antiseptic remedies 
published on page 8, Marchand's Peroxide of Hydrogen (medicinal) is 
the most powerful bactericide, and it is absolutely harmless. 
I have explained on page 7 that : When Marchand's Peroxide of 
Hydrogen (medicinal) comes in contact with any open and infected 
surface, either of the skin or the mucous membrane, ozone is set free, 
the microbes are instantly destroyed, as well as the unhealthy secretions 
which are caused by their action, and then the diseased surface is 
thoroughly disinfected and made perfectly clean and healthy. The 
residue of this reaction is water and a small quantity of coagulated 
albumen. 
In fact, this Marchand's Peroxide of Hydrogen treatment is based 
upon the indisputable results which are obtained when a Hay-fever 
patient is going to the White Mountains, where the atmospheric con- 
ditions are such that the air contains always a small quantity of ozone. 
The constant breathing of this ozonized air accomplishes the cure of 
this disease in a very short time. 
Hay Fever will always be prevented by an early application of MaY- 
chand's Peroxide of Hydrogen (medicinal), in those cases which occur 
regularly at known periods of the summer. When the disease has 
developed, the same treatment will check it within three or four days, 
and the cure is effected in less than two weeks ; but it is advisable to 
continue the treatment during the whole Hay-fever season 
The remedy should be applied as follows : 
First-Spray the nostrils and the throat copiously and repeatedly 
twice or three times every day with a mixture of 
1 tablespoonful of Marchand's Peroxide of Hydrogen (medicinal) 
with 3 to 8 tablespoonfuls of water (cold or lukewarm). 
according to the degree of inflammation. 15 
Second-By means of Charles Marchand's Hand Atomizer and Ozon- 
izer, an inhalation of ozonized vapor should be administered with a 
mixture thoroughly made of 
half Marchand's Peroxide of Hydrogen (medicinal), 
half chemically pure glycerine. 
The above should be carefully mixed and renewed every three days. 
(See description and cuts of Charles Marchand's Hand Atomizer and 
Ozonizer, pages 18-19.) 
The duration of each inhalation should not exceed ten minutes, and 
should be taken three to six times daily. Inspirations should be as deep 
jmd prolonged as possible.* 
INFLUENZA.-LA GRIPPE. 
Causes.-This disease is caused by microbes of a special kind which 
act upon both the respiratory organs and the nervous system. 
The local symptoms of this infectious disease are a severe naso- 
pharyngeal catarrh with headache, sore throat and bronchitis. 
The general symptoms are a feeling of lassitude, with acute pains 
in the limbs and back, accompanied with fever and profuse perspira- 
tion. 
The internal treatment which may be prescribed by the physician 
with an appropriate diet will soon relieve the patient from the general 
symptoms, but, the danger is due to complications which frequently 
accompany the Influenza, such as laryngitis, bronchitis, acute lobar 
pneumonia and pleurisy. 
In fact, the local symptoms, viz.: The inflammatory condition of the 
respiratory tract must be promptly subdued in order to prevent the 
microbian infection from producing dangerous complications. 
Treatment of the Local Symptoms.-Owing to its destructive 
action upon the germs which are the cause of Influenza, Marchand's 
Peroxide of Hydrogen (medicinal) will promptly subdue the inflam- 
*In very severe cases an application of Glycozone to each nostril, morning and evening, will acceler- 
ate the cure. (See page io, article headed "Catarrh of the Nose.") 
The ozonized vapor inhalations constitute a very important part of the treatment for this disease, as 
it relieves immediately Asthma, which always accompanies Hay Fever. 16 
matory condition of the respiratory organs, and it should be applied as 
follows: 
First.-Spray the nostrils and the throat copiously and repeatedly 
every three hours with a mixture made of 
i tablespoonful of Marchand's Peroxide of Hydrogen (medicinal} 
with 4 to io teaspoonfuls of lukewarm water 
according to the sensitiveness of the mucous membrane. 
Second.-In order to reach the seat of the disease, deeply located in 
the bronchial tubes, by means of Ch. Marchand's Hand Atomizer and 
Ozonizer, (p. p. 18-19) inhalations of ozonized vapor must be admin- 
istered three to six times every day with a mixture thoroughly made 
of 
half Marchand's Peroxide of Hydrogen (medicinal) 
half chemically pure glycerine. 
Shake well and renew this mixture every three days. 
This treatment will not only check the local symptoms, but it will 
also prevent the patient from being subsequently troubled with chronic 
bronchitis. 
Note.-How to Use Marchand's Peroxide of Hydrogen 
(medicinal) in Acute Catarrh of the Nose.-In case of excessive 
tenderness of the mucous membrane of the nostrils, the spraying of 
the nose with a cold mixture of Marchand's Peroxide of Hydrogen 
(medicinal) with water, may cause a severe pain for a few moments. 
In order to prevent this momentary pain from becoming too great, 
it is advisable to mix the remedy with lukewarm water instead of cold 
water. When such is the case, the required quantity of the mixture 
should be made fresh at each spraying. 
Dr. Robert T. Morris advises an application of a three per cent, 
solution of cocaine before spraying the nostrils with diluted Peroxide 
of Hydrogen (medicinal) in order to quiet the smarting sensation. 
(See page 55.) 17 
DIRECTIONS FOR USING CH. MARCHAND'S HAND 
ATOMIZER AND OZONIZER IN THE 
DIFFERENT CASES. 
The three ounce glass bottle L is graduated in twelve parts, each 
part corresponding to one-quarter of one ounce, so that it is very easy 
to mix the medicines in the required proportions. 
The working of this apparatus will be easily understood by referring 
to the illustrations of the apparatus given p. p. 18-19. 
First.-The proper mixture of Marchand's Peroxide of Hydrogen 
(medicinal) with chemically pure glycerine for administering ozonized 
vapor inhalations is thoroughly made in the bottle Z, as is shown on 
cuts No. 2 and No. 3. 
Then, by quickly and repeatedly pressing the terminal soft rubber 
bulb Z, the air is forced through the bottle Z, and produces a coarse 
spray in the vaporizing bulb A. The concussion of the spray against 
the glass breaks up the mixture, and a large amount of fine ozonized 
vapor escapes in a continuous flow through the bent glass tube F, as 
represented on cut No. 2, or through the straight glass tube F, as 
shown on cut No. 3. 
When the condensed liquid in the bulb A reaches the lower part of 
the neck B, it should be emptied in the bottle Z, by disconnecting 
the spray-tube D. Then reconnect the parts, and the apparatus is 
again ready for use. 
Second.-When the apparatus is needed to spray either the throat or 
the nose, Marchand's Peroxide of Hydrogen, (medicinal) is mixed with 
the necessary quantity of water in the graduated bottle Z, as shown 
on cuts No. 4 and No. 5. 
Note.-Some practitioners believe that Peroxide of Hydro- 
gen may be inhaled by means of any of the ordinary inhalers, 
the same being placed in a jacket vessel of water heated to 
i2o°-i4o° Fahr. This method is absolutely wrong, for the follow- 
ing reason: When Peroxide of Hydrogen is heated to i2o°-i4o° Fahr., 
steam, oxygen (formula O), and only traces of ozone are inhaled by 
the patient (see foot note, page 7, article headed "Oxygen Inhala- 
tion.") On the contrary, when Peroxide of Hydrogen (medicinal) 
vapor is mechanically produced by means of the Hand Atomizer and 
Ozonizer the vapor which reaches the diseased tissues has the same 
curative properties as Peroxide of Hydrogen itself. 18 
CHARLES MARCHANI)'S 
COMBINED 
HAND ATOMIZER AND OZONIZER. 
DESCRIPTION: 
Cut No. i.-This cut represents apparatus when unpacked from its original box. 
Cut No. 2.-This cut represents apparatus ready for inhaling vapor through the nose 
in the treatment of Asthma, Bronchitis, and lung diseases. 
Cut No. 3.- This cut represents apparatus ready for inhaling vapor through the 
mouth in the treatment of Asthma. Bronchitis and lung diseases. 19 
Cut No. 4.-This cut represents apparatus ready for spraying the throat. 
Cut No. 5.- This cut represents apparatus ready for spraying the nostrils. 
Each separate part of the appara- 
tus is designated by the following 
letters: 
A.-The vaporizing glass bulb, with its 
two openings, S and C. 
D.-The curved spray-tube (hard rubber). 
£.-The bent glass tube. 
F.-The slightly curved glass tube. 
G.-The straight tip (hard rubber). 
H.-The nasal tip (hard rubber). 
I. I.-The two soft rubber bulbs. 
K.-The soft rubber stopper. 
L.-The glass bottle containing the rem- 
edy. 
Cut No. 6.-This cut shows the different parts of the Hand Atomizer and Ozonizer 
when disconnected. 20 
CAUTION. 
The spray-tube should be kept clean by passing tepid water through it at 
least twice a week. Should it get clogged, disconnect the vaporizing 
bulb A and the bottle L, unscrew the tip G, and blow both ways through 
the spray-tube, or pass a thin wire through it, as you would do for any 
ordinary spray atomizer. 
The above-described apparatus is entirely made of glass and hard rubber, 
because no metal should come in contact with Marchand's Peroxide of 
Hydrogen (medicinal). Use only silver, hard rubber, glass, or porcelain 
spoons to measure either Marchand's Peroxide of Hydrogen (medicinal) 
or Glycozone. 
Treatment of Asthma.-By means of Ch. Marchand's Hand 
Atomizer and Ozonizer, inhalations of ozonized vapor should be admin- 
istered three to six times daily. Any similar apparatus made of metal 
should never be used in connection with Marchand's Peroxide of 
Hydrogen (medicinal). 
The action of vaporized Marchand's Peroxide of Hydrogen (medic- 
inal), or ozonized vapor, upon the diseased surface of the bronchial 
tubes or the cells of the lungs is similar to the action of this bactericide 
upon any open sore or ulcer which is invaded by microbes. The 
microbian element is destroyed at the contact of ozone, which is set 
free, and the diseased tissues are purified and made healthy. 
The mixture for inhalations which has given the most satisfactory 
results is made of 
one-half Marchand's Peroxide of Hydrogen (medicinal), 
mixed with one-half chemically pure glycerine. 
Mix well together by shaking the bottle, and renew this mixture 
every two days. 
The duration of each inhalation should not exceed ten minutes, and 
after each inhalation, during the winter, the patient should remain 
in-doors for fifteen or twenty minutes. 
In many cases of long standing it will be found very beneficial to the 
patient to take internally every day two or three tumblerfuls of ozon- 
ized water made of 
i ounce Marchand's Peroxide of Hydrogen (medicinal) 
with 2 pints of water. 
This will cleanse and purify the stomach and regulate the bowels. 
Bronchitis-Treatment.-By means of Charles Marchand's Hand 21 
Atomizer and Ozonizer three inhalations of ozonized vapor should be 
administered daily. 
It is the most efficacious local treatment which can be prescribed to 
subdue this disease, on account of the harmless, although very power- 
ful, antiseptic and healing properties of Marchand's Peroxide of 
Hydrogen (medicinal). 
It quickly checks profuse bronchial secretion, and by its stimulating 
action upon the diseased tissues of the bronchial tubes an absolute 
cure is effected in a very short time. 
Mixture for inhalations : 
One-half Marchand's Peroxide of Hydrogen (medicinal) 
with one-half chemically pure glycerine. 
This mixture should be made perfect by shaking the bottle, and 
renewed every three days. 
And as a beverage, drink daily three or four tumblerfuls of ozonized 
water made of 
i ounce Marchand's Peroxide of Hydrogen (medicinal) 
mixed with 2 pints of water. 
This beverage will have the most beneficial effect upon the stomach,, 
which is always more or less affected by droppings from the throat. 
In this malady Marchand's Peroxide of Hydrogen (medicinal) 
destroys the microbes or germs which are the cause of the disease, 
the unhealthy secretions of the bronchial tubes disappear, and the 
diseased tissues are made healthy. 
Whooping-cough-Causes.-Dr. Burger, of Bonn, Germany, 
and Dr. Affanassieff, of Russia, have demonstrated the presence of 
micro-organisms in Whooping-cough sputum. Dr. Affanassieff has 
prepared, with all the precautions, for microscopical experimentation, 
a small portion of the expectoration of a Whooping-cough patient, 
which showed large numbers of short rod bacteria, part singly, partly 
in two and of larger chains. 
With pure cultures of these rod bacteria the investigator has made 
several experimental inoculations upon animals. A solution of this 
culture upon agar-agar, at least eight days old, in one-half a cubic 
centimetre of common salt, was made and injected into the windpipe 
or lungs of dogs and rabbits, of course under antiseptic precautions. 22 
The animals all contracted a disease similar to Whooping-cough, 
often complicated with Broncho-pneumonia. 
Several died, and the autopsy showed that the mucous membranes 
of the bronchi, of the trachea, and even of the nose, are the chief seats 
of the injected bacteria. 
This same bacterium was found in the lungs and respiratory mucous 
membranes of children who died of Whooping-cough. 
Dr. Affanassieff considers it to be the true cause of Whooping- 
cough, and names it the " bacillus tussis convulswce." 
Dr. Schwenker (London Lancet, January 7, 1888) and Dr. Wenat 
{Medical News, June 2, 1888) have confirmed Dr. Affanassieff's obser- 
vations. 
One hundred cubic centimetres of the pure culture, containing a 
considerable quantity of the above-mentioned micro-organisms, have 
been submitted to the action of three cubic centimetres of Marchand's 
Peroxide of Hydrogen (medicinal). The complete annihilation of the 
bacteria has been effected in less than seventy seconds of contact. 
Treatment.-Whooping-cough, being caused by a microbian affec- 
tion, requires antiseptic treatment ; and Marchand's Peroxide of Hy- 
drogen (medicinal), applied in the following manner,will effect promptly 
an absolute cure : 
First-Spray frequently and copiously the nose, throat, pharynx, and 
larynx with a mixture made of 
1 tablespoonful of Marchand's Peroxide of Hydrogen (medicinal) 
with 4 to 6 tablespoonfuls of water (cold or lukewarm). 
The patient may swallow some of the remedy without discomfort, as 
it is beneficial and perfectly harmless. Three to four applications 
every day will be sufficient in most cases. 
Second-By means of the Hand Atomizer and Ozonizer, administer 
ozonized vapor three to six times daily, in order to insure the complete 
destruction of the microbian element in the respiratory organs. 
. The mixture for inhalations should be made of 
half Marchand's Peroxide of Hydrogen (medicinal) 
with half chemically pure glycerine. 
Mix well together, and renew the mixture every three days.* 
* The disorders of the stomach which often accompany this disease will always be surely pre. 
vented and cured by the use of Glycozone as an internal treatment. Dose : i teaspoonful of Gly- 
cozone, diluted in a wineglassful of water, three times daily. 23 
Consumption, Phthisis, Tuberculosis of the Lungs- 
Causes.-It is a well-demonstrated fact that Consumption or Phthisis 
is caused by a microbe of a particular species which has been discov- 
ered by Dr. Koch, of Berlin, and which is called the Bacillus Tuber- 
culosis of Koch. 
Bacillus Tuberculosis 
in Sputum x 1250 diameters. 
With pure cultures of this bacillus, Dr. Koch and other scientific 
authorities have made experimental inoculations upon animals. A 
solution of this culture upon agar-agar was made and injected into the 
windpipe or lungs of dogs. The animals all contracted the Tubercu- 
losis of the Lungs or Consumption. This bacillus is located in tuber- 
cules, and it causes the formation of ulcerated cavities of the lungs. 
The bacillus tuberculosis is readily destroyed by antiseptic remedies; 
but although the annihilation of the microbian element is accomplished 
almost instantaneously by the action of Marchand's Peroxide of 
Hydrogen (medicinal), this remedy will not cure Consumption when 
the disease has reached such a degree of development that the lung 
tissue has broken down. In fact, if it should be possible to bring this 
remedy into contact with all parts of the lungs which are invaded by 
the bacillus, undoubtedly the cure of Consumption might be always 
effected by the ozonized vapor inhalations.* 
Treatment.-Frequent and deep ozonized vapor inhalations should 
be administered three to six times daily, with a mixture of 
2 to 3 tablespoonfuls of Marchand's Peroxide of Hydrogen (medicinal) 
with i tablespoonful of chemically pure glycerine well shaken. 
Renew this mixture every three days. 
* Whenever ozonized vapor is mentioned, it means " vapor produced by the Ozonizer from the 
mixture of Marchand's Peroxide of Hydrogen (medicinal) with chemically pure glycerine." 24 
The duration of each inhalation should not exceed ten minutes, and 
inspiration should be as deep and as prolonged as possible. The 
remedy will reach the lungs if administered either through the nose or 
mouth, by means of Charles Marchand's Hand Atomizer and Ozonizer. 
(See page 18.) 
Remain in-doors for fifteen to twenty minutes after each inhalation 
during the cold weather. 
It is easy to understand that, the ozonized vapor coming into con- 
tact with the bacillus tuberculosis, located in the ulcerated cavities of 
the lungs, " ozone," which is set free, destroys the microbian element 
immediately, as explained before on page 7. 
When Consumption has not taken developments beyond its first or 
-second stages-that is, when the ulcerated cavities caused by the bacil- 
lus tuberculosis are limited and can be easily reached by the ozonized 
vapor-the above treatment prevents absolutely the spreading of the 
infection and a cure is effected. But in all cases of Consumption, no 
matter at what stage of the disease, the relief of the patient will be 
surely and quickly obtained by the Marchand Peroxide of Hydrogen 
treatment. 
Ozonized vapor has no corrosive, toxic, or injurious action upon the 
healthy tissues of the lungs ; on the contrary, it has very powerful 
stimulating properties. In addition to the inhalations, the administra- 
tion of three tumblerfuls daily of ozonized water, made of 
i| ounces of Marchand's Peroxide of Hydrogen (medicinal) 
with 2 pints of water, 
after each meal, will be found very helpful to the relief of the patient. 
Sore Throat, Angina, Quinsy, Tonsilitis, and all Inflam- 
matory Diseases of the Throat. 
Treatment.-Spray or gargle the throat copiously and frequently 
with a mixture of 
1 tablespoonful of Marchand's Peroxide of Hydrogen (medicinal) 
with 3 to 6 tablespoonfuls of water (cold or lukewarm;. 
You may swallow the remedy without discomfort, as it is rather bene- 
ficial. In case of Tonsillar Abscesses gargle more frequently (every 
two hours, for instance), in order to destroy surely and quickly the pus 
which is present. 25 
Laryngitis.-Marchand's Peroxide of Hydrogen (medicinal) is cer- 
tainly the safest remedy to apply in order to subdue this disease. 
Spray or gargle three times every day with a mixture made of 
i tablespoonful Marchand's Peroxide of Hydrogen (medicinal) 
with 2 to 6 tablespoonfuls of water, 
and swallow a portion of the remedy. 
In many cases, ozonized vapor inhalations will accelerate the cure. 
Pharyngitis.-Spray or irrigate copiously the pharynx three times 
every day with a mixture of 
i tablespoonful Marchand's Peroxide of Hydrogen (medicinal) 
with 3 to 7 tablespoonfuls of water ; 
swallow a portion of the remedy, and administer ozonized vapor inhala- 
tions morning and evening. 
Appropriate internal medication may accelerate the cure. 
Croup, Membraneous Croup.-This disease seems to be caused 
by the same specific virus as Diphtheria, but it shows a milder grade of 
infection. 
When fully developed, whitish spots or membraneous exudations are 
observed in the larynx. After the membrane is once formed, if left 
alone it may be cast off in the form of a cylinder, in bands or shreds. 
Some recent experiments have proved that Marchand's Peroxide of 
Hydrogen (medicinal) destroys these membranes after a short contact, 
and by its curative properties the diseased surface is rendered healthy. 
In case of Membraneous Croup, the nose, throat, mouth, pharynx, 
and larynx should be flooded every two hours with a mixture of 
i tablespoonful of Marchand's Peroxide of Hydrogen (medicinal) 
with 4 to 6 tablespoonfuls of water (cold or lukewarm). 
The membranes are destroyed, and by using this remedy frequently 
and very freely you prevent their reproduction. 
In this way the physician will observe that the inflamed parts are 
thoroughly and quickly cured, and there is no danger of the patient 
being exposed to the suffocation resulting from the development of 
these infected membranes.* 
* As an internal treatment, i tablespoonful of Glycozone diluted in a wineglassful of water and 
taken three times a day will prevent any disturbance of the stomach and regulate the bowels. 26 
Diphtheria-Causes.-Diphtheria is at first a local disease (see 
page 2), which is secondarily propagated to the general organism by 
a contagious virus located about the tonsils; this virus is an albuminoid 
substance invaded by a large number of bacteria called micrococci. 
Marchand's Peroxide of Hydrogen (medicinal) destroys this virus 
instantaneously, and it has no injurious effects upon the surrounding 
healthy tissues. 
These cuts illustrate a well-developed case of Diphtheria before 
and after its cure by use of Marchand's Peroxide of Hydrogen (medici- 
nal). Time taken to destroy the micrococci was less than 70 seconds. 
Magnified Diphtheritic Membrane, 800 
Diameters. Figure 1 shows the bacteria 
called micrococci. Fig. 2 shows the fibrin. 
Showing the same membrane after short 
contact with Peroxide of Hydrogen. The 
bacteria are destroyed; the fibrin remains 
normal. 
Directions for Use.-Spray or gargle copiously, every two hours, 
the nose, throat, mouth, pharynx, and larynx with a mixture of 
t tablespoonful Marchand's Peroxide of Hydrogen (medicinal) 
with 2 tablespoonfuls of water (cold or lukewarm). 
It is beneficial to swallow the remedy, or a portion of it, in gargling. 
The virus or germs are readily destroyed from the contact with 
Peroxide of Hydrogen (medicinal), and the contagion is therefore 
prevented. 
When Diphtheria is well developed it is necessary to spray the 
child's nostrils, throat, mouth, pharynx, and larynx more frequently 
with a mixture made of 
i tablespoonful Marchand's Peroxide of Hydrogen (medicinal) 
with i tablespoonful of water (cold or lukewarm.) 27 
Dr. Geo. B. Hope of the Metropolitan Throat Hospital of New York, 
and many other leading physicians, recommend the use of Marchand's 
Peroxide of Hydrogen (medicinal) full strength, particularly when the 
disease spreads rapidly. 
The remedy may be applied by means of a camel's hair brush (free 
from any metallic parts) or by means of an ordinary atomizer entirely 
made of glass or hard rubber. 
Any portion of the remedy which finds its way into the larynx or 
stomach is beneficial rather than harmful. 
Adults and children old enough to gargle the pharynx and rinse the 
mouth will get a better effect in this way* 
Dyspepsia-Predisposing Causes.-Deficient gastric secretion, 
with resulting fermentation of food, is perhaps the most prevalent 
cause of dyspepsia. 
The two main constituents of gastric juice, namely, acid and pepsin, 
may be deficient in quantity or disturbed in their relative proportions. 
A certain amount of acid is absolutely essential to the digestive process, 
while a small amount of pepsin may be sufficient to digest a large 
amount of albuminoid food. 
Bidder and Schmidt have made repeated analysis of pure gastric 
juice, and their results are confirmed by the analysis of five specimens 
of gartric juice, free from saliva, and taken by Charles Marchand from 
dogs. 
The gastric juice of a dog is composed of: 
Water 968.20 
Pepton and pepsin 17.12 
Free muriatic acid 2.98 
Alkaline chlorides 4.16 
Ammonium chloride 0.51 
Chlorine 5.16 
Phosphates. 
Lime 1.54 
Magnesia 0.28 
Iron 0.05 
The most careful analysis proved beyond doubt that fresh gastric 
juice contains only one mineral acid-that is, muriatic acid. 
* As an internal treatment, i teaspoonful of Glycozone diluted in a wineglassful of water, ad- 
ministered every three to four hours will prevent the microbian infection developing in the 
stomach of the patient, and that is a very important result to obtain in order to avoid the infection 
of the system. 28 
Exciting Causes.-The profession well know that excess in eat- 
ing and drinking, imperfect mastication and insalivation, the use of 
indigestible and unwholesome food and of alcohol, the imperfect 
arrangement of meals, over-drugging, etc., are chiefly the exciting 
causes of Dyspepsia, and indigestion is the immediate consequence. 
Constipation of the bowels is an almost universal accompaniment of 
deranged digestion, and when persistent for years it is apt to lead to 
the most disastrous consequences. 
The most prominent of the local symptoms of Dyspepsia are : A sense 
of fulness and distention after eating, discomfort during digestion, 
lack of appetite and eructations, or heart-burn, flatulence, regurgitations 
of food, and sometimes, in acute cases, nausea and vomiting. 
Now that I have resumed the causes of Dyspepsia, which produce 
a general inflammation of the coats of the stomach, the profession 
know that the innumerable remedies which have been recommended to 
subdue this disease may be classified as follows: 
First-Remedies having a stimulating action upon the secretion and 
muscular coats of the stomach. 
Second-Introduction in the stomach of a necessary amount of one 
or several of the constituent elements of the gastric juice, in order to 
make it normal. 
Third-Remedies having the property to lessen the abnormal irri- 
tability. 
Fourth-Remedies having the property to facilitate digestion. 
It is evident that any remedy which will restore the coats of the 
stomach to their normal condition will contribute to effect an absolute 
cure, providing the patient will observe a proper regimen. 
Glycozone, by its wonderful antiseptic and healing properties, not 
only prevents the fermentation of the food in the stomach, but it cures 
also the inflammation or irritation of the mucous membrane in a very 
short time. Consequently, the most powerful and efficacious treatment 
to be applied, in order to remove the causes of Dyspepsia, can be for- 
mulated as follows : 
Before or after each meal administer t teaspoonful of Glycozone in 
a wineglass nearly filled with water, stirred and taken three or four 
times daily. 
Use no other remedy. 
The digestion is accomplished, from the beginning of its applications 29 
without the least discomfort. The relief is almost immediate, and a 
cure absolute, if earnestly used. 
After a few days the secretion of gastric juice is made normal, and 
the most acute cases of Dyspepsia, those of long standing, are perma- 
nently cured within two to six months of this treatment, when all other 
remedies have failed. 
Catarrh of the Stomach, or Gastritis, Chronic or Recent.- 
The mucous membrane of the stomach is usually the seat of thin 
disease. 
Among the direct exciting causes of gastric inflammation, corrosive 
poisons and the excessive use of alcohol are recognized to be more 
prevalent than any others. 
Chronic Catarrh of the Nose is often the cause of Gastritis on 
account of the large quantity of infected secretions which, after de- 
veloping in the nasal cavities, find their way into the stomach. 
The immediate consequence of that dropping is to produce an 
inflammation of the coats of the stomach, and little by little the 
microbian infection produces a general morbid condition having the 
symptoms of Catarrh of the Stomach. 
In cases of acute Catarrh of the Stomach the autopsy shows that 
the mucous membrane is covered with a thick, tenacious, stringy 
mucus ; the secretion of gastric juice is very imperfect, and the diges- 
tion of food cannot be accomplished. 
Glycozone, by destroying the morbid element which is the cause 
of this disease, rapidly subdues the inflammatory condition of the 
coats of the stomach, and then the mucous membrane, being restored 
to its normal state, the secretion of the gastric juice will become 
regular, and the digestion will not be disturbed any more. 
Treatment.-Administer, three or four times daily, before or after 
each meal, 
i to 2 teaspoonfuls of Glycozone, 
diluted in a wineglassful of water, well stirred. 
This treatment will never fail to accomplish an absolute cure within 
two to six months, providing the physician will impress upon the mind 
of his patient that he should take his meals regularly and with sobriety. 
Ulcer of the Stomach.-This disease is due to various causes, 
■of which the immediate effect is to interfere with the digestion. 30 
Vomiting of food is an indication of Gastric Ulcer, and in severe 
cases it is followed by hemorrhage. 
The gastric juice is secreted with deficiency, and in order to remove 
the cause of this disorder a powerful antiseptic treatment is required. 
The most satisfactory results are obtained : 
First-If the patient use as a beverage a small quantity of ozonized 
water at each drink, this ozonized water being made of 
i ounce of Marchand's Peroxide of Hydrogen (medicinal) 
with 2 pints of water. 
The microbian element is readily destroyed by the small quantity of 
ozone which is set free at the immediate contact of the ulcerated 
surface. 
Second-The healing part of the treatment consists in the adminis- 
tration of 
i to 2 teaspoonfuls of Glycozone 
diluted in a wineglassful of water, three or four times daily, before or 
after eating. 
This treatment is absolutely harmless, and the relief of the patient 
is obtained almost immediately. 
An absolute cure is effected within two to six months. 
Scarlet Fever-Causes.-It is a proven fact that this disease is 
caused by bacteria of the micrococcus species, as shown by the cut 
below, which illustrates a magnified portion of excretions of an ulcer 
of the larynx (8oo diameters) taken from a Scarlet-fever patient. 
Fig. I shows the bacteria of 
the scarlet fever. 
Fig. 2 shows the fibres of the 
tissue and globules. 31 
Every physician knows that Scarlet Fever is a contagious affection 
to the highest degree, and that it may be communicated by anything 
that has touched the patient, such as air, food, clothing, sheets, furni- 
ture, curtains, etc. All discharges from bowels, kidneys, nose, mouth, 
eyes, ears, and skin are dangerous ; and the poison may remain active 
for months or years by means of clothing packed away in drawers. 
Treatment.-The germs which cause this disease are readily 
destroyed by Marchand's Peroxide of Hydrogen (medicinal); and the 
most powerful local medication is obtained in the following manner : 
Spray or gargle the throat copiously and repeatedly every 2 to 3 
hours with a mixture made of 
1 tablespoonful Marchand's Peroxide of Hydrogen (medicinal) 
with 3 to 5 tablespoonfuls of water (cold or lukewarm).* 
As a preventive treatment for secondary infection : On the third day 
■of Scarlatina Fever, the whole body of the patient should be washed, 
morning and evening, with equal parts of 
Marchand's Peroxide of Hydrogen (medicinal) 
and tepid water. 
Use a porcelain dish and a clean soft sponge. 
This local treatment does not preclude the internal medication, 
which may be deemed necessary by the attending physician. 
Typhoid Fever-Causes and Treatment.-It is a well-known 
fact that contaminated water is the cause of this disease. 
The following cut illustrates the typhoid bacille, magnified 1250 
diameters, from pure culture : 
* As a beverage, Glycozone should be administered three times daily. Dose-i teaspoonful 
diluted in a wineglassful of water. 32 
Marchand's Peroxide of Hydrogen (medicinal) destroys those 
microbes instantaneously. Consequently, a beverage made of 
i ounce Marchand's Peroxide of Hydrogen (medicinal) 
with 2 to 3 pints of water 
constitutes the most efficacious and powerful antiseptic treatment, 
which always prevents both pyaemia and septicaemia.* (See report of 
Dr. H. F. Wiggin, p. 75, also article headed Cholera-Typhus, page 44.) 
This antiseptic medication does not preclude the general treatment 
which may be prescribed by the attending physician. 
Anthrax-Carbuncle.-This affection, which is caused by the 
Bacillus Anthracis, is at first a local disease which requires a very 
powerful antiseptic treatment, immediately after the carbuncle has 
been opened by a surgical operation or otherwise. 
'Phe following cut illustrates the Bacillus Anthracis, magnified 1250 
diameters, from pure culture: 
Bacillus Anthracis x 1250 
diameters. 
The Bacillus Anthracis is readily destroyed by Marchand's Peroxide 
of Hydrogen (medicinal.) 
Treatment.-Wash or irrigate the sore, morning and evening, with 
Marchand's Peroxide of Hydrogen (medicinal), full strength, taking 
great care that the liquid should be thrust into the discharging sinuses, 
in order to secure the complete destruction of the microbian element; 
the pus is also destroyed, and the cleansing of the sore is made perfect. 
As a local dressing a double thickness of surgical lint should be 
♦Glycozone, administered three times daily in the proportion of i teaspoonful diluted in a wineglass- 
ful of water, will prevent the disorders of the stomach. 33 
soaked into Glycozone and applied to the sore; and an over-covering 
of oiled silk should be used. 
The above local treatment does not exclude the internal medi- 
cation. 
Yellow Fever.-According to the recent researches made by Dr. 
Paul Gibier, of the Faculte de Medicine de Paris, France, it seems to 
be a positive fact that Yellow Fever is caused by bacteria which are 
located in the intestines. This theory being supported by other 
prominent bacteriologists, the most logical treatment, in order to sub- 
due this intestinal infection, is to administer some laxatives in connec- 
tion with antiseptic remedies. (See article headed Cholera-Typhus p.44.) 
The use of bichloride of mercury solution has been recommended 
as a rectal injection, although it should be absolutely condemned, 
owing to its corrosive and toxic properties. 
A 3 per cent, solution of bichloride of mercury is equivalent, as a 
bactericide, to a 2 per cent, solution of Peroxide of Hydrogen (medic- 
inal). Then 1 per cent, solution of Peroxide of Hydrogen (medic- 
inal), which corresponds to a 4^ volume capacity, has the same bac- 
tericide power as a 1% per cent, solution of bichloride of mercury. 
(See on page 8, "Comparative Tests.") 
Treatment.-By means of a glass or hard rubber syringe the 
physician should prescribe a rectal injection, administered three times 
daily, with one pint of a mixture made of 
2 ounces of Marchand's Peroxide of Hydrogen (medicinal) 
with 1 pint of lukewarm water; 
and he will obtain the same disinfectant action as he would obtain by 
using half a pint of a 1 % per cent, bichloride of mercury solution. The 
use of such a quantity of bichloride of mercury should evidently kill 
both the germs of the disease and the patient. 
WOMEN'S WEAKNESSES. 
Whites, Leucorrhcea, etc.-These very troublesome and pain- 
ful diseases require not only an appropriate internal medication, but 
also a powerful local antiseptic treatment. 
All the remedies prescribed to subdue these affections are more or 
less injurious on account of their corrosive, irritating, or poisonous 34 
properties; and, in fact, they produce very often an aggravation of the 
disease. 
On the contrary, Marchand's Peroxide of Hydrogen (medicinal), 
which is more powerful than any one of these antiseptics (see page 
8, "Comparative Tests"), has, by its stimulating action upon the dis- 
eased mucous membrane of the vagina, a prompt and curative effect. 
Treatment.-By means of either a glass or hard rubber syringe, 
copious injections should be administered at least twice daily, morn- 
ing and evening, with a mixture of 
i to 3 ounces of Marchand's Peroxide of Hydrogen (medicinal) 
with i pint of lukewarm water, 
according to the tenderness of the infected surface. 
The above treatment will promptly accomplish an absolute cure 
where all other remedies have failed. 
In cases of acute inflammation or ulceration of the womb, injections 
should be administered copiously and repeatedly morning and even- 
ing, with a mixture made of 
2 to 4 ounces of Marchand's Peroxide of Hydrogen (medicinal) 
with i pint of lukewarm water.* 
Abscess of the Vagina-Treatment.-In case of an abscess of 
the vagina, the profuse suppuration which follows a surgical opera- 
tion, will be stopped by repeated injections administered with Mar- 
chand's Peroxide of Hydrogen full strength. 
From the time the pus formation is checked, inject repeatedly the 
Peroxide (morning and evening) diluted in the proportion of 
i ounce of Marchand's Peroxide of Hydrogen (medicinal) 
with 8 ounces of lukewarm water. 
In order to secure a prolonged contact of the remedy with the dis- 
eased surface, the patient must lay down on her bed at the time she 
injects the remedy into the cavity. 
♦Besides the Peroxide of Hydrogen treatment, in chronic cases it is necessary to apply the Glycozone 
on lint into the vagina morning and evening. 35 
When the healthy granulations generate too quickly, under the 
stimulating action of the Peroxide, it is necessary to inject (three 
times every day) a weaker solution made of: 
i ounce Marchand's Peroxide of Hydrogen (medicinal). 
with 16 ounces lukewarm water. 
After the cleansing of the sore has been accomplished by the above 
treatment, apply glycozone on absorbent lint into the cavity. 
Fistula (Recto-Vaginal)-Treatment.-At first inject Mar- 
chand's Peroxide of Hydrogen (medicinal) full strength until the dis- 
charge ceases being abundant. (See article by Dr. Lewis H. Adler, 
page 92, also article by Dr. Jos. M. Mathews, page 92.) 
Then, morning and evening, inject into the cavity a mixture made 
of 
1 part Marchand's Peroxide of Hydrogen (medicinal) 
with 2 to 4 parts of lukewarm water. 
The local dressing must be made with glycozone on absorbent lint. 
Gonorrhoea.-This disease is known to be characterized by a local 
infection of the urethral canal, which is caused by bacteria of the gon- 
ococcus species. 
These germs, as well as the unhealthy excretions which are present, 
are readily destroyed by Marchand's Peroxide of Hydrogen (medic- 
inal), and the physician may prescribe three injections every day, to 
be administered by means of a glass or hard rubber syringe, with a 
mixture of 
1 ounce Marchand's Peroxide of Hydrogen (medicinal) 
with 4 to 8 ounces of water, 
according to the degree of inflammation; retain this liquid in the 
canal for a few seconds.* (See p. 52, Report of Dr. E. Charest, also 
page 83, article by W. Roberts, U. S. A.) 
The dangers of stricture resulting from the use of caustic or 
astringent remedies are absolutely avoided, and the cure is affected in 
half the ordinary time if the above treatment is earnestly followed. 
*In case of chronic Gonorrhoea, or Gleet, besides the above treatment the physician should prescribe 
■one injection every night with Glycozone. 36 
The appropriate internal medication should be prescribed by the 
physician. 
When the degree of inflammation of the urethra is excessive, each 
injection should be preceeded by cocaine or ether for the purpose of 
quieting the smarting. 
LIST OF DISEASES WHICH ARE SUCCESSFULLY TREATED BY 
MARCHAND'S PEROXIDE OF HYDROGEN (MEDICINAL) AND BY 
"GLYCOZONE." 
The fact that Marchand's Peroxide of Hydrogen (medicinal) is the 
most powerful pus-destroyer is so well known among physicians who 
have used it that it is acknowledged to be unsurpassed as a cleansing 
agent for pus-discharging surfaces, especially in cases otherwise difficult 
of access, for the instant it toqphes pus,"ozone" is set free, effervescence 
takes place, and continues until the pus is destroyed. Physicians may 
apply this remedy with perfect safety, and they will always obtain the 
most satisfactory results in the treatment of affections caused by germs, 
or microbes. 
For example, Marchand's Peroxide of Hydrogen should be applied 
to the treatment of the following diseases: 
Open Boils, Open Abscesses, Phlegmonous Abscesses, Mastoid Ab- 
scesses, Ulcers (syphilitic or not), Scrofulous Sores, Cancerous Sores, 
Bed Sores, Local Gangrene, Broken Ampulla or Blisters, Aphthae or 
Ulcerations of the Mouth, Stomatitis, Burns, Herpes Zoster or Zona, 
Eczema, Skin Diseases, Itch, Piles, Fistula, and all microbian affec- 
tions. 
Treatment.-Asa rule, the above-mentioned diseases should be 
treated as follows: 
First-By means of a glass dropper, or otherwise, apply Marchand's 
Peroxide of Hydrogen (medicinal) to the sore, and take care not to 
remove the white foam which is generated when this remedy comes in 
contact with the diseased surface; let it stand until it disappears, 
which occurs in a few minutes. 
Then, by means of a glass dropper or a soft camel's hair brush, apply 
the Glycozone to the sore and cover it with a double thickness of 
surgical lint soaked in Marchand's Peroxide of Hydrogen (medicinal). 
It is advisable to apply both Marchand's Peroxide of Hydrogen 37 
(medicinal) and glycozone full strength, until the pus formation is 
checked. 
When the discharge ceases being abundant, the Peroxide must be 
diluted with water and the glycozone should be thoroughly mixed with 
chemically pure glycerine, in order to prevent the healthy granula- 
tions from forming too quickly. 
THE USE OF MARCHAND'S PEROXIDE OF HYDROGEN 
(MEDICINAL) IN DENTAL SURGERY. 
Owing to its wonderful bactericide properties, Ch. Marchand's Per- 
oxide of Hydrogen (medicinal) is the most powerful remedy to apply 
in order to cure the dental affections which are known to be caused 
by germs or microbes, such as, for example: 
Alveolar Abscesses and Abscesses of the Inferior Maxilla. 
Laceration, Inflammation, and Ulceration of the Gums; Stomatitis. 
Necrosis and Caries of the Teeth. 
'The profession well know that the therapeutical agents used for the 
treatment of these diseases have been as follows: 
Chloride of Sodium.-Salicylic Acid.-Chloride of Zinc.-Nitrate of Sil- 
ver.-Creosote, and Carbolic Acid. 
With the exception of chloride of sodium, which has no appreciable 
destructive action upon the microbian element, the other above-men- 
tioned remedies are poisonous, and, owing to their corrosive proper- 
ties, the dentists cannot always limit their action to the affected parts. 
The creosote and carbolic acid have such an offensive odor that 
they should not be used at all. (See foot-note page 9, article headed,. 
"The Dangers of Carbolic Acid.") 
On the contrary, Charles Marchand's Peroxide of Hydrogen (medic- 
inal) is absolutely harmless; it is almost odorless and tasteless.* 
By the healing power of this wonderful remedy, the diseased surface 
is made healthy and the surrounding tissues remain in their normal 
condition. 
It has no destructive action upon the enamel of the teeth. 
A tooth, being submitted for several days to the action of Mar- 
* It is used without danger or risk of poisoning the patient, and yet it is the strongest bactericide and 
purifier known. (See "Comparative Tests," page 4.) 38 
chand's Peroxide of Hydrogen (medicinal) full strength, remains in- 
tact, but it is bleached. 
GENERAL DIRECTIONS. 
Alveolar Abscess and Abscess of the Inferior Maxilla- 
Treatment.-When an Alveolar Abscess is caused by any constitu- 
tional derangement, internal medication would necessarily have to be 
prescribed. 
The local treatment demanded is such as will destroy the accumu- 
lated pus. 
At first, the abscess should be broken by a surgical operation or 
otherwise, then the cleansing and destruction of pus will be accom- 
plished instataneously, as follows: 
By means of a silver, gold, or platinum syringe, administer into the 
■cavity, morning and evening, one or two injections with a mixture of 
i part Ch. Marchand's Peroxide of Hydrogen (medicinal) 
with 3 to 4 parts of water. 
In the treatment of abscesses of the Inferior Maxilla, where there is 
no free egress for the pus and debris, much more energetic treatment 
is necessary, and the dentist need not hesitate to administer injections, 
morning and evening, with a mixture of 
i part Ch. Marchand's Peroxide of Hydrogen (medicinal) 
with 2 parts of water. 
In chronic cases, in order to prevent the sore from closing between 
two applications, floss silk or absorbent cotton impregnated with 
glycozone, should be applied immediately after each cleansing of the 
cavity. 
Besides the above local treatment, the mouth should be kept clean 
by frequent washings with a mixture of 
i tablespoonful of Ch. Marchands Peroxide of Hydrogen (medicinal), 
diluted in half a tumblerful of tepid water. 
By following this treatment, the diseased tissues become healthy 39 
after one or two applications, and an absolute cure is effected in half 
the ordinary time. 
Laceration, Inflammation, and Ulceration of the Gums- 
Stomatitis-Treatment.-Charles Marchand's Peroxide of Hydro- 
gen (medicinal) is the most powerful remedy which may be applied in 
order to subdue these very tenacious and painful affections. 
It should be used freely and repeatedly as a tooth-wash, morning and 
evening, in the following proportion: 
i ounce Medicinal Peroxide of Hydrogen, 
diluted with half a pint of water. 
Rinse the mouth well, and retain this liquid in the mouth for one 
minute or so at each washing. No injurious action whatever upon the 
enamel of the teeth need be feared. 
The gums are strengthened by this treatment, healthy granulations 
develop very rapidly, and an absolute cure is quickly effected. 
When the above diseases of the gums are caused by constitutional 
derangement, internal medication would necessarily be prescribed. 
Necrosis and Caries of the Teeth.-Caries is a vary common 
cause of Necrosis. Excessive medication, especially with mercury, will 
sometimes produce partial, and, occasionally, total Necrosis. 
The profession know that the most common agents that injure the 
teeth are originated in the mouth by the decomposition of animal and 
vegetable food. 
Inflammation of the mucous membrane of the mouth is a common 
result of diseased teeth. 
The Caries may be constitutional or local, and, if constitutional, the 
dentist knows that it may be modified by therapeutic treatment of the 
general system. 
In all cases of Caries, the aggravation of the disease will always be 
prevented by using frequently and copiously, as a tooth-wash, a mix- 
ture of 
t to 2 ounces of Ch. Marchand's Peroxide of Hydrogen (medicinal), 
with half a pint of water. 
Rinse the mouth well, at least morning and evening, and retain this 
liquid in the mouth for one minute or so at each washing. 40 
When the Caries is local, an absolute cure is promptly accomplished 
by the above treatment. 
MARCHAND'S PEROXIDE OF HYDROGEN (MEDICINAL), 
USED AS A WASH IN THE TREATMENT OF THE 
INFLAMMATORY DISEASES OF THE EYES. 
GLYCOZONE IS THE MOST POWERFUL HEALING AGENT FOR 
THESE CONTAGIOUS DISEASES. 
Catarrhal Conjunctivitis, or Ophthalmia-Causes.-The pro- 
fession well know that all forms of Conjunctivitis which are 
accompanied by secretion are caused by germs which develop under 
more or less favorable circumstances, producing a local infection which 
is contagious to the highest degree. 
The virulence of the contagion increases with the impurity of the 
atmosphere, and this disease is communicated by conveyance of 
secretion from one to another, by towels, handkerchiefs, etc., with a 
prodigious rapidity. 
Besides a proper ventilation, it is necessary to isolate sick people, 
and also to keep them perfectly clean, in order to prevent the contagion; 
for instance, when any form of Conjunctivitis appears in a public insti- 
tution it is urgent to put all the affected persons apart from the healthy. 
Numerous analyses which I have made in order to ascertain the 
nature of the remedies ordinarily applied in the treatment to this 
disease show that they are as follows: 
Nitrate of Silver.-Sulphate of Zinc.-Sulphate of Copper.-Bichloride of 
Mercury.-Red Oxide of Mercury.-Carbolic Acid.-Alum.-Sugar of Lead. 
-Tannin.-Borax.-Boracic Acid.-Sulphate of Atropine.-Cocaine. 
Although some of these remedies have a destructive action upon 
the microbian element which is the cause of this disease, such remedies 
should be condemned, owing to their corrosive and irritating properties. 
In some instances they have the most injurious effects upon the cornea, 
and very often destroy not only the germs of the disease, but also 
weaken or destroy the optic nerves, and for this reason their use proves 
more dangerous than the disease itself. 
Tannin, borax, and boracic acid are not dangerous remedies; but 
their bactericide power is so feeble that a cure could not be effcted by 
their action, since they cannot remove the cause of the infection. 41 
On the contrary, Marchand's Peroxide of Hydrogen (medicinal) 
removes the cause of the disease, and Glycozone, by its strength- 
ening and curative action, makes the mucous membranes of the eye 
grow stronger daily. 
Treatment.-First the eyelids should be cleansed by a thorough 
washing made with a mixture of 
i ounce Marchand's Peroxide of Hydrogen (medicinal) 
with 2 pints of lukewarm water; 
then, by means of a glass dropper, apply to the inner portion of the 
eye, next to the nose, one, two, or more drops of Glycozone every night 
before retiring and the first thing in the morning. 
If no dropper is at hand, apply the remedy with a soft camel's-hair 
brush, dipped in the Glycozone, to the outer edge of the eye, with an 
outward motion of the brush, or it may be applied with the finger. In 
whatever manner the Glycozone is applied, it penetrates the inner sur- 
face of the eye by simply opening and shutting the eye repeatedly fora 
few times. 
At first it causes smarting, and often very severe pain for a few 
seconds, but it is only momentary and soon passes away. 
Purulent Conjunctivitis - Ophthalmia Neonatorum, or 
Ophthalmia in Children.-The oculists well know that the Ophthal- 
mia Neonatorum, or Ophthalmia in Children, is much more dangerous 
in its consequences than the Catarrhal Conjunctivitis. 
This disease, which is the most frequent source of blindness in 
children, can always be cured if treated as follows: 
First cleanse,the eyelids by a thorough washing with a mixture of 
i ounce Marchand's Peroxide of Hydrogen (medicinal) 
with i pint of lukewarm water. 
This should be done three times, or at least morning and evening, 
every day. 
Each cleansing should be immediately followed by the application 
of Glycozone. (See explanations given on page 40, article headed 
"Catarrhal Conjunctivitis.") 
Granulated Eyelids.-Same treatment as Catarrhal Conjunctivitis 42 
In all diseased conditions of the eyes the patients should expose 
themselves to air-draughts or bright light as little as possible, and the 
bowels should be kept open by a suitable internal medication. 
SUPPURATIVE AND INFLAMMATORY DISEASES OF THE 
EAR-TREATMENT BY MARCHAND'S PEROXIDE OF 
HYDROGEN (MEDICINAL) AND "GLYCOZONE." 
Owing to its wonderful bactericide properties Marchand's Peroxide 
of Hydrogen (medicinal) is of great value in cases of obstinate 
chronic suppuration of the middle ear, especially in such cases where 
it is difficult to reach all the suppurating tract by any local agent. 
The fact that it can be forced through the osseous sinuses without 
danger highly commends its value in the different diseases just men- 
tioned. 
In case of profuse suppuration, the cleansing and destruction of 
pus should be made perfect by applying the remedy in the following 
manner: 
By means of either a glass or a hard rubber syringe inject into the 
cavity, morning and evening, half an ounce of Marchand's Peroxide of 
Hydrogen (medicinal), full strength; let the remedy act during two or 
three minutes, and then apply into the ear, as a dressing, a small 
quantity of absorbent cotton well impregnated with Glycozone. 
Two washings with Peroxide of Hydrogen and two dressings with 
Glycozone, applied every day, will cure the most obstinate chronic 
case in a very short time. 
When the disease is not chronic, the suppuration being relatively 
limited, instead of applying Marchand's Peroxide of Hydrogen (medic- 
inal), full strength, it should be diluted with lukewarm water, in the 
proportion of half-and-half. 
The local dressing should be always made with pure Glycozone, 
as heretofore explained. (See article headed Peroxide of Hydrogen 
and its use in Ear Diseases, by Dr. Walter B. Johnson, page 91.) 
INFLAMMATORY DISEASES OF THE BLADDER. PURU- 
LENT CYSTITIS. TREATMENT BY MARCHAND'S 
PEROXIDE OF HYDROGEN (MEDICINAL) AND 
GLYCOZONE. 
Cystitis may be acute or chronic; it is always caused by germs. 
In all cases of Cystitis the internal medication should be earnestly 
observed, and the patient should not drink irritating beverages. 
The profession well know that the remedies ordinarily applied in the 
local treatment of this disease have rather palliative than curative 
properties. 43 
In Peroxide of Hydrogen (Medicinal) we have a remedy which 
readily destroys the pus, and also the microbian element which is the 
cause of the disease. 
Peroxide of Hydrogen (Medicinal) will always prevent the develop- 
ment of any affections which very often accompany Cystitis, such as 
Phlebitis, Nephritis and Gangrene of the bladder. 
Treatment.-By means of a double current hard rubber catheter, 
irrigations of the bladder should be made at least twice daily, morning 
and evening, with six to eight fluid ounces of a mixture made of 
two ounces of Marchand's Peroxide of Hydrogen (Medicinal) 
with one pint of tepid water. 
At the beginning of the treatment of the chronic Cystitis, one ounce 
of Marchand's Poroxide of Hydrogen (medicinal) full strength should 
be injected into the bladder, every day. 
By using the double current catheter the gas which generates into 
the bladder finds its way out through the outlet opening. 
In cases of urethritis and also in cases of acute inflammation or 
ulceration of the bladder, when the pain is very great, Dr. Robert T. 
Morris, of New York, recommends that the application of Peroxide of 
Hydrogen should be preceeded by Cocaine or Ether, for the purpose of 
quieting the smarting. (See article headed, "The Necessary Peroxide 
of Hydrogen, by R. T. Morris, M. D.," p. 55.) 
In addition to the above local treatment with Peroxide of Hydrogen, 
the introduction into the bladder of a small quantity of Glycozone will 
always accelerate a cure. 
Every evening before retiring, inject into the bladder one fluid 
ounce of the following mixture: 
half Glycozone, 
half C. P. Glycerine. 
The above remedies are the most powerful topical agents which can 
be used in order to subdue the inflamm <tory diseases of the bladder. 44 
CHOLERA:-TYPHUS 
AND 
DISEASES OF THE ALIMENTARY TRACT CAUSED BY 
MICROBES. 
Treatment.-Elmer Lee, A. M., M. D., of Chicago, Ill., reports 
in the New York Medical Record, December 17th, 1892, some prac- 
tical experiments in the treatment of cholera by irrigation of the in- 
testinal canal. 
The following ent illustrates his process used at St. Petersburgh, 
Russia, during the recent epidemic there, 1892. 
The irrigation is accomplished by means of a soft rubber tube F, one 
metre in length and of suitable size to be introduced into the rectum, 
in front of the promontory of the sacrum, into and up through the 
sigmoid flexure and into the descending colon. This tube which is 
connected with a glass reservoir E (see cut), should not be too small 
nor too large, in order to facilitate its introduction through the folds 
of the sigmoid portion of the lower bowel. In fact, the greatest diffi- 45 
culty to be encountered, is to successfully pass the tube in front of 
the promontory of the sacrum, and enter it into the sigmoid flexure. 
The tube should be of proper firmness to prevent it from bending or 
buckling upon itself when the end, (which in all cases should be 
rounded), comes in contact with the obstructing folds of the intes- 
tine. 
Dr. Lee reports very satisfactory results from a thorough irriga- 
tion of the intestines with lukewarm water containing a small pro- 
portion of liquid soap made of vegetable oil, potash, and glycerine, in 
connection with peroxide of hydrogen (medicinal), as an internal 
treatment. 
By following Dr. Lee's system of irrigation of the intestinal canal, 
with a large amount of the above solution (two to three gallons), the 
whole amount of infected matter which is present in the intestinal 
canal, is mechanically carried away; after which, by a second thor- 
ough irrigation of the intestinal tract with one to two gallons of 
lukewarm water containing 4 per cent, of Marchand's peroxide of 
hydrogen (medicinal), any coma-bacilli which may remain in the in- 
testinal tract will be readily destroyed. 
In addition to irrigation or washing out of the intestines, Dr. Lee 
administers internally peroxide of hydrogen (medicinal), two ounces 
diluted with eight ounces of distilled water, in cupful doses every 
three hours. The addition of distilled water is made in order to in- 
crease the bulk of fluid in the stomach. 
It is but justice to credit Dr. Elmer Lee with the first practical ap- 
plication of irrigation, in the treatment of infectious diseases of the 
alimentary tract. 
The report of his experience at St. Petersburgh, forms a most val- 
uable contribution to the medical literature of the day. This treat- 
ment being practically the removal of poisonous matter and a local 
extermination of the coma-bacillus by means of a bactericide which 
has no deleterious effect upon animal cells, is based upon logical 
grounds and cannot fail to receive the attention of all scientific men. 
In consequence of the results obtained by Dr. Lee, it is reasonable 
to conclude that similar treatment in case of typhus, yellow fever 
and other infectious diseases of the alimentary tract, will prove most 
efficacious. 46 
IMPORTANT INFORMATION REGARDING GLYCOZONE. 
Glycozone is a stable compound resulting from the chemical reac- 
tion which takes place when C. P. glycerine is submitted under 
special conditions, to the action of fifteen times its own volume of 
ozone, under normal atmospheric pressure at a temperature of O° C. 
The presence of water (and other foreign substances) in the gly- 
cerine, changes the nature of this reaction, so that instead of produc- 
ing glycozone, we obtain formic acid, glyceric acid, and other sec- 
ondary products having deleterious effects upon the animal cells. 
Glycozone being hydroscopic, must be tightly corked, so as to 
avoid being deteriorated by the moisture contained in the atmos- 
phere. 
Although glycozone absorbs water readily, it does not deteriorate 
when kept at a temperature of no degrees F as long as it retains its- 
proper anhydrous condition. 
The therapeutic properties of glycozone and Marchand's peroxide 
of hydrogen (medicinal) differ in the following particulars: 
Peroxide of hydrogen (medicinal) instantly destroys the morbid ele- 
ments of diseased surfaces of the skin or of the mucous membrane 
with which it comes in contact, leaving the tissues beneath, in a 
healthy condition. 
On the contrary, glycozone acts more slowly, but not less certain 
as a stimulant to healthy granulations. Its healing action upon dis- 
eased mucous membrane is powerful and harmless in the treatment 
of inflammatory diseases of the stomach. In such cases it gives an 
immediate relief to the patient. (See Dyspepsia, page 27.) 
In chronic inflammation of the intestines, a rectal injection admin- 
istered every day with a mixture composed of 
R Glycozone, 3 1 
Lukewarm water, 312 
soon relieves obstinate conditions. 
A syringe made exclusively of hard rubber or glass, should be 
used in all instances where either peroxide of hydrogen (medicinal), 
or glycozone is used as an enema. 
After any diseased or suppurating surface has been cleansed by 
peroxide of hydrogen (medicinal), the application of glycozone stim- 
ulates healthy action, and accelerates a cure. 47 
General Directions for Use.-Glycozone may be given for dis- 
eases of the stomach, in doses of one to two teaspoonfuls in a wine- 
glassful of water immediately after each meal. In catarrhal diseases, 
it should be applied in full strength as often as required. 
As an application to wounds and suppurating surfaces it should be 
used without dilution. For further directions see information under 
the different diseases mentioned in this pamphlet. 
Caution.-Glycozone is a peculiar chemical compound, and not a 
mixture of peroxide of hydrogen (medicinal) with glycerine. 
These two liquids when mixed do not form a stable product, but 
develop substances which have injurious effects upon animal cells. 
Such a mixture when freshly made, has no healing properties simi- 
lar to glycozone. On the contrary glycozone is stable, harmless and 
always effective. OPINION OF THE MEDICAL PROFESSION. 
See a report on Hydrogen Peroxide, read at the Indiana Institute of Homoe- 
opathy, May 19, 1885, published in the Medical Era, July, 1885, and republished in 
response to numerous requests, after having been revised, in the number issued April, 
1886. By Wm. B. Clarke, M.D., Indianapolis, Ind. 
In this very elaborate article Dr. Wm. B. Clarke says : " I have used several 
makes of Peroxide of Hydrogen, foreign and domestic, and find the purest and best 
to be Ch. Marchand's Peroxide of Hydrogen (medicinal)." 
See also a report on Hydrogen Peroxide read before the New York Society for 
Medico-Scientific Investigation, by W. W. Blackman, M.D., Brooklyn, N. Y. This 
report is published in the North American Journal of Homceofathy, July, 1886, pp. 
554 to 564. 
SOME CLINICAL FEATURES OF DIPHTHERIA AND THE 
TREATMENT BY PEROXIDE OF HYDROGEN. 
By GEORGE B. HOPE, M.D., New York. 
Surgeon Metropolitan Throat Hospital; Professor Diseases of Throat, University 
of Vermont. 
(Extract from the New York Medical Record, October 13, 1888.) 
The sentiment, so long divided, with regard to the constitutional or local 
inception of diphtheria, seems to be now almost universal in the direction of the latter 
theory. Consequently, in the light of this opinion, it is clear that the rational 
treatment must rest more on the recognition of some local agent which will surely 
destroy the specific germ before a full development of the constitutional infection is 
reached, rather than on any system of general medication which might be presumed 
to act more or less as an antidote in combatting the septic influences occurring in the 
course of the disease 
On account of their poisonous or irritant nature, the active germicides have a 
utility limited particularly to surface or open-wound applications, and their free use in 
reaching diphtheritic formations in the mouth or throat, particularly in children, is 
unfortunately not within the range of systematic treatment. In Peroxide of 
Hydrogen, however, it is confidently believed will be found, if not a specific, at least 
the most efficient topical agent in destroying the contagious element and limiting the 
spread of its formation, and at the same time a remedy which may be employed in the 
most thorough manner without dread of producing any vicious constitutional effect. 
Although the Peroxide is by no means of recent date, its medicinal value has been 
chiefly confined to the cleansing of foul ulcers and suppurating wounds, and there is 
hardly more than a casual mention of its utility in the treatment of diphtheria 
previous to a paper of Dr. Mount Bleyer on this subject.* Quite independently of 
these observations, somewhat over eighteen months since, at the Metropolitan Throat 
Hospital, several cases of well-marked buccal diphtheria were treated with the 
* The Medical Record, August 13, 1887. 49 
Peroxide, with the effect of confirming in the most satisfactory manner the results 
obtained by Dr. Bleyer. The report of these cases was consequently omitted, 
pending the experiences it was supposed others would be quick to furnish on a more 
extended scale of the new remedy so warmly advocated. Among the somewhat small 
number of trial cases which have appeared at various times in the medical press, there 
are none in which a distinctly negative opinion is expressed, and where only a partially 
satisfactory result is attained there has appeared to be sufficient cause to permit a 
reasonable explanation for the fact 
A further explanation for the uncertain results attending the use of the Peroxide 
lies in the direction of the preparation itself, as also in the manner of its topical 
application. The usual descriptions allow the diluted strength of from three to seven 
volumes of distilled water. Inasmuch as the efficacy depends upon the ozonized 
oxygen in solution, it has seemed desirable to rely on the full strength of the officinal 
preparation of fifteen volumes, especially when used in the fauces, where any slight 
irritation from its acidity is not apparent. In all the cases treated, a fresh, standard 
Marchand's preparation of fifteen volumes was that on which the experience of the 
writer has been based. An equally important element is in making the application in 
such a manner as to produce the most determined effect on the diseased tissues with 
as little local disturbance as possible. Swabbing the tonsils and pharynx is the rough 
and ready method commonly resorted to, with the second motive of detaching, if 
possible, the membranous formation. Such treatment is not only unnecessarily 
harsh toward the patient, but also in intrinsic efficacy falls far short in securing the 
best therapeutic value of the remedy. It is properly recognized that the removal of 
the membrane, unless it occurs spontaneously, is not favorable to the local conditions ; 
moreover, the glairy mucus coating the surface does not permit the application to 
come fairly in contact with the disease, or so superficially as to require the most 
constant repetition. The latter criticism holds the same bearing, only modified in a 
degree, to the hand-ball vapor and spray-producing instruments that have been 
recommended. 
A steady, coarse spray, with an air-pressure of twenty pounds or more, will in a 
few moments' time produce a more positive action than prolonged efforts to reach the 
fauces by means of cotton applicators. The force of the spray should be sufficient to 
cleanse at once the surface accumulations, as it destroys the necrosial elements with 
which it comes in contact. In this manner the removal of the debris and the action on 
the deeper structure go hand in hand. 
It will be noticed that immediately on contact with the Peroxide, a white, cloudy 
coagulum is formed on and about the diphtheritic patches, readily floated off and 
exposing a more sharply defined and a flatter, smooth and whiter base. Properly 
speaking, there is no liquefaction of the exudation, but the decomposition of the 
inflammatory products is so complete that the cells are broken up and freed from the 
entangling fibrous net-work beneath. In a particular instance, in the case of 
apparently a continuous diphtheritic slough, involving the tonsils and extending in an 
unbroken line across the margin of the soft palate, a solitary application exhibited 
this effect to such a degree that the natural color of the mucous membrane appeared 
in spots as if the exudation might have bridged across sound tissue without as yet 
securing attachment to the sub-epithelial layers. 
How frequently the treatment is to be followed up depends to a considerable 
extent on the density as well as the area of the surface involved. It may be said, 
however, that two applications a day, in the great majority of cases, should be 
sufficient, if thoroughly performed, to arrest all danger of extension and accomplish 
the gradual resolution of the local formation. 
If the experience of the writer is confirmed, it is apparent how much time, 
trouble and unnecessary handling is obviated when contrasted with the methods 
outlining hourly or half-hourly swabbing, or, as one has more frankly expressed it, 
" scrubbing," with nauseating applications, and culminating in the exhaustion of the 
patient, if not the most indifferent success. No reasonable objection can be raised 50 
either on the score of the expense or the difficulty of transporting the apparatus 
necessary, as small portable air-receivers can be readily obtained in the instrument 
shops, on the model of those devised by Codman & Shurtleff, of Boston, and which 
for the purpose are equally efficient as the larger stationary office fixtures. 
The more recent experience of Dr. Gifford (the Medical Record, September I, 
1888), establishing the active germicidal properties of Peroxide of Hydrogen, rapidly 
diminishing in proportion to its dilution in what might be called a geometrical ratio, 
appears to emphasize in a marked degree the clinical observations on which the main 
features relating to its employment have been based. 
SOME PRACTICAL HINTS IN CONNECTION WITH INTU- 
BATION OF THE LARYNX, AND A RESUME OF 206 
CASES OF DIPHTHERIA OPERATED ON FROM 1886 
TO 1888. 
By J. MOUNT BLEYER, M.D. 
Yew York Medical Journal, February 2 1888. 
. . . . Irrigation.-This is an admirable method of washing away the 
products of the local lesion. I use a No. 8 soft-rubber catheter which is attached to a 
fountain-bag syringe ; the catheter is passed into the nostrils, first the right and then 
the left. The solution which is used is made by taking Peroxide of Hydrogen 
(Charles Marchand's), fifteen volume solution, chemically pure, one ounce to twelve 
ounces of water. With this solution irrigate each nostril thoroughly. After this has 
been done, the next move is to wash out the mouth, pharynx, and larynx. If the 
child can be managed without forcing the mouth open, there is no need of the 
insertion of a gag ; but if not use it. The patient is to be held well forward over a 
basin for the reception of the returning fluid. Make a second mixture of the Peroxide 
of Hydrogen of the strength of four drachms to twelve ounces of water. The catheter 
is passed well down into the larynx, the surrounding parts, and thoroughly irrigated. 
The fluids are very seldom swallowed, and if this fluid mixture should be swallowed 
there is no danger of poisoning, as it is a perfectly harmless antiseptic. The fluid is 
generally immediately expelled by coughing. The mouth is to be kept wide open and 
the head well forward. By this mode of treatment patches of membrane, inspissated 
muco-pus, etc., can be washed away without difficulty and without pain. My 
experience with Peroxide of Hydrogen for the last four years has made me familiar 
with its varied use in the treatment of diseases of the nose and throat. From a 
consideration of the action of Peroxide of Hydrogen upon the deposit of diphtheritic 
membranes, and the rapid reproduction of bacteria, it will at once be evident that the 
earlier the application of the remedy is adopted, the better. While the membrane is 
thin and friable, the action of this agent is thorough, quick, and effective ; the deposit 
melts down before the contact of it like sugar in water, to be reproduced in a short 
time and again removed until the diseased tissue beneath can be plainly seen free 
from this characteristic covering. In this way, also, the spread of the membrane is 
checked and its limits often sharply circumscribed, until after some days, when the 
germinating power of the membrane is conquered and the poison ceases to produce its 
kind, no more deposit takes place, and the diseased tissues heal. In view of the rapid 
reproduction of bacteria already mentioned, it is evident that the applications should 
be no longer apart than two hours, or even less, according to the rapid reproduction 
{Extract.} 51 
of the membranes. Gargling may be practiced by those who are able, but irrigation 
is preferred, as a more thorough application is thereby made. Irrigation is easily 
learned by the nurse, and there is absolutely no danger connected with its use. 
For internal use I give the preference to Glycozone, which is chemically pure 
glycerine saturated with active ozone. It is to be used locally, as a substitute for 
bichloride of mercury, carbolic acid, permanganate of potash. This is the most 
powerful of all organic disinfectants and bactericides. I give to a child over two years 
of age half a teaspoonful of Glycozone, well diluted with water or milk, every two 
to four hours, and under that age twenty drops. , . . 
ON THE MEDICINAL USES OF HYDROGEN PEROXIDE. 
By E. R. SQUIBB, M.D., Brooklyn. 
Read before the Kings County Medical Association, February 5, 1889, during the 
discussion on diphtheria, and published in Gaillard's Medical Journal for 
March, 1889, p. 267. 
{^Extract.} 
Throughout the discussion upon diphtheria very little has been said of the use of 
the Peroxide of Hydrogen, or hydrogen dioxide, yet it is perhaps the most powerful of 
all disinfectants and antiseptics, acting both chemically and mechanically upon all 
excretions and secretions, so as to thoroughly change their character and reactions 
instantly. The few physicians who have used it in such diseases as diphtheria, 
scarlatina, small-pox, and upon all diseased surfaces, whether of skin or mucous 
membrane, have uniformly spoken well of it so far as this writer knows, and perhaps 
the reason why it is not more used is that it is so little known and its nature and action 
so little understood. Until within the last few years, except in a few manufacturing 
processes, it was chiefly known as a chemical curiosity, rarely seen because difficult to 
make. 
In order to use it intelligently both the pharmacist and the physician must know 
something of its nature and properties. The name hydrogen dioxide expresses its 
composition, and its formula, H2 O2 represents this name. Hydrogen monoxide, H2 O, 
or water, can under certain conditions be made to combine with a second molecule of 
oxygen, the result being a water-like liquid, H2 O2. 
This second atom of oxygen is very loosely combined, and the compound molecule 
is always on a strain to break up into water and oxygen, and when it breaks up, either 
slowly or rapidly, the oxygen separates in that nascent or most active and potent of its 
conditions next to the condition known as ozone. It is in the change of this breaking 
up into water and active oxygen that the latter element exerts its power, and the 
simple contact with organic matters, which are themselves of complex nature and in 
condition to be changed, is sufficient to break up the dioxide and liberate the active 
oxygen. For example, some albuminoids are instantly changed by contact with 
hydrogen dioxide, as is shown by rinsing the mouth with a dilute solution, when the 
albuminoid matters of the secretions are at once coagulated. Then, as all virus is 
albuminoid, whether propagative or not, it is destroyed, or by coagulation rendered 
inert by simple contact with this agent, just as it is by contact with corrosive 
sublimate. This simple experiment of rinsing the mouth with a dilute solution of 
hydrogen dioxide and examining the discharged liquid can hardly fail to convince any 
one of the destructive potency of this active oxygen on some albuminoids, and of its 
thoroughly cleansing effects upon the mucous surfaces. 
Now, if diphtheria be at first a local disease, and be auto-infectious-that is, if it 
be propagated to the general organism by a contagious virus located about the tonsils, 
and if this virus, be as it really is, an albuminoid substance, it may and will be 52 
destroyed by this agent upon a sufficient and a sufficiently repeated contact. . . . 
All kinds of spray and injection apparatus can now be easily obtained with fittings of 
hard rubber or glass, and such only should be used. 
A child's nostrils, pharynx, and mouth may be flooded every two or three hours, or 
oftener, from a proper spray apparatus with a two-volume solution without force, and 
with very little discomfort; and any solution which finds its way into the larynx or 
stomach is beneficial rather than harmful, and thus the effect of corrosive sublimate is 
obtained without its risks or dangers. Adults and children old enough to gargle the 
pharynx and rinse the mouth will get a better effect in this way, equally without much 
discomfort, from a three-volume solution; and this applies not only to diphtheria, but 
to scarlatina and other conditions of the mouth and throat which require cleansing and 
disinfecting. As vaginal injections in cases of uterine cancer, etc., the strength must 
be increased until the disinfectant effect is obtained. A copious flushing out with a 
one-volume solution will often be sufficient. When wetted cloths are laid over external 
sores an over-covering of oiled silk should be used. 
As, in passing through several hands after leaving those of the maker, a little 
mismanagement may spoil the solution, some easily applicable tests of quality and 
strength are needed. 
So long as the solution will yield any active oxygen at all, it will give this off with 
active effervescence when poured onto a crystal or two of potassium permanganate. 
A solution containing only a quarter of its volume will give an effervescence so strong 
as to be misleading, and therefore a quantitative test is needed. The following is a 
modification of a testing process given to the writer, with much other useful information 
by Mr. Charles Marchand, of No. io West 4th Street, New York City, one of the 
oldest and best makers of Peroxide of Hydrogen, and one who supplies it to all parts 
of the country. ... 
If this agent is to be generally used in the treatment of diphtheria, as it well 
deserves to be on well established principles of action, it is very important that it be 
freely applied in the earliest possible stages of the disease, or while it is yet local; and 
therefore the agent should be easily and promptly accessible in places known to physi- 
cians, and not over a mile apart throughout a city, and in hands which know the agent 
well, and know how to keep it from change and to dispense it on physicians' orders. 
If all pharmacists should undertake to keep it-or even all the prominent ones- 
it would soon share the fate of many other important medicines. . . . 
PEROXIDE OF HYDROGEN FOR GONORRHOEA. 
REPORT OF DR. E. CHAREST. 
(Medical World, Philadelphia, Pa., June, 1889.) 
Editor Medical World: 
I intended for some time to give to the readers of the Medical World my favorite 
treatment for gonorrhoea and gleet, and I will take the opportunity of Dr. H. E. 
Stroud's offer to do so now. 
What I consider the simplest, quickest and least harmful treatment of gonorrhoea 
is Peroxide of Hydrogen in injection △ j to the § of distilled water, three to five times 
a day. 
Internally ten to fifteen grains of sodae bicarb., every three hours, to keep the 
urine alkaline. 
Walking to be avoided as far as possible, also beer, coffee, pepper, etc.; keep the 
bowels regular; use a syringe with tapered end and soft rubber tip for the injections. 53 
The Peroxi.de of Hydrogen is used a good deal in commerce for bleeching pur- 
poses, so that there are different qualities of it on the market. 
For medical use it must be neutral to the litmus paper, odorless and colorless.* 
This kind you may have from C. Marchand, 10 West Fourth Street, New York City. It 
must be kept at a temperature below 65° F., and no metal must come in contact with it. 
In writing to the above-named firm you will receive a pamphlet on this valuable: 
remedy well worthy to be studied. 
I consider it the best germicide, as it is the least harmful and the most effective. 
For the past two weeks I have used it in the form of a spray, in one of the worst 
cases of eczema, of four years' standing, which had so far resisted the assaults of a 
dozen doctors backed up by as many drug stores, and is now almost well. 
For syphilitic ulcers, soft chancres, diphtheria, ulcerated cervix, in fact, whenever 
there is pus or gems, this is the true remedy. 
In gonorrhoea, when the penis is highly inflamed, use the injection four to five 
times a day and the inflammation will rapidly be subdued, leaving the urethra in a 
perfectly healthy condition. The use of a suspensory is a great relief to the patient. 
The fl. ext. of black willow is very good for the erections. 
It is also the remedy par excellence in gleet, and there is nothing like its inhalation 
to cut short a paroxysm of asthma. 
I don't claim the Peroxide of Hydrogen (H2 O2) to cure gonorrhoea in three or 
eight days, for I don't believe there is anything that will do so without danger; but it 
will cure it in three weeks and leave the unfortunate in the best of condition. 
R. Charest, M.D. 
St. Cloud, Minn. 
MEDICINAL USE OF HYDROGEN PEROXIDE. 
(Editorial New York Medical Record.') 
It is with pleasure that we peruse the new issue of Squibb's Ephemeris for July, 
1889, confident as we are that whatever it tells us is in'accord with the latest scientific 
advances, and is the result of careful thought and research. 'Among its articles is one 
by E. R. Squibb, on "Hydrogen Peroxide" (published also in Gaillard's Medical 
Journal, March, 1889). This substance which is one of the most powerful and at the 
same time the least harmful of all antiseptics and disinfectants, has never come into 
general use, probably because it is so unhandy and spoils so readily (Dr. Squibb thinks 
it is because it is so little known and so little understood). It is made in large quanti- 
ties by several large firms, but is used chiefly in the preparation of secret remedies. 
Its properties have been known for a long time. It is a compound of hydrogen and 
oxygen which is easily decomposed, yielding water and nascent oxygen which quickly 
oxidizes substance with which it is in contact. The mere application of a solution of 
Peroxide of Hydrogen to certain albuminoid substances is sufficient to liberate its oxy- 
gen, which immediately coagulates the albuminoid substance within its reach. Thus 
all sorts of virus, whether propagative or not, are destroyed, or by coagulation rendered 
inert in its presence, just as when strong corrosive sublimate solutions are applied to 
them. The undiluted liquid peroxide is from its nature very unstable, and on slight dis- 
turbance breaks up into water and oxygen with almost explosive rapidity. Therefore it 
is never made nor used undiluted, but is always dissolved in water. The " Peroxide of 
Hydrogen " which is furnished to the physician is really a solution of the pure liquid 
in water to which a little hydrochloric acid has been added, the acid being necessary to 
prevent rapid decomposition of the peroxide. A solution which will yield its own 
volume of active (nascent) oxygen is called a one-volume solution. The fifteen-volume 
solution (yielding fifteen times its volume of nascent oxygen) is that which is generally 
* See page 5, article headed " Important Information on Peroxide of Hydrogen." 54 
supplied by the makers. It is put up in pint bottles, containing about fifteen fluid 
ounces, sold at $9 a dozen. It is colorless and nearly odorless, tastes slightly acid, 
and leaves a slight fleeting, not unpleasant after-impression. Changes in this solution 
are indicated by the formation of bubbles of gas, which rise through the liquid o. 
adhere to the sides of the bottle, and also by increased pressure within the bottles. 
At or below 59° F., the solution does not change for a long time. At 68° F., it does 
change, sometimes very rapidly, giving off oxygen gas. The solutions, whether strong 
or dilute, should be kept cool, outside of the window of the sick-room in winter, and 
on ice or in ice-water in summer. The bottles in which the solutions are contained 
must not be held in the hand for any considerable time, as its warmth will cause 
decomposition. It must not be kept in contact with metals, nor applied by means of 
metal apparatus, as it not only ruins the instruments, but forms poisonous salts from 
the metal. It does not attack hard rubber or glass. It is not necessary to apply it as 
strong as when it comes from the maker. The ordinary fifteen-volume solution sold 
is not injurious, but it is stronger than necessary, and to use it undiluted is wasteful. 
For the irrigation of a child's nostrils, pharynx, and mouth, a two-volume (made by 
adding two ounces of the fifteen volume solution to a pint of water solution, may be 
used every two or three hours, and any part of this solution passing into the stomach 
will do good rather than harm. 
Adults and children who can gargle-especially in scarlatina and diphtheria-may 
use, as a gargle and mouth-wash, a three-volume solution (three ounces of fifteen- 
volume solution to a pint of water). For vaginal injections, as in cancer, etc., a 
thorough washing with the one-volume solution will often suffice, but it may be neces- 
sary to increase the strength until the desired effect is produced. When cloths wetted 
in a solution are laid upon external sores they should be covered with oiled silk. The 
methods for testing the activity of any solution are given in full, but need not be 
repeated here. Mr. Charles Marchand, of No. 10 West Fourth Street, New York 
City, is referred to as one of the best makers and furnishers of hydrogen peroxide. 
It is very necessary to get a good article, as careless preparation and after-handling 
may render it inactive. It is desirable that it should be applied very early when used 
in diphtheria, before the deposits in the throat have caused disease of the adjacent 
parts or of the general system. 
PEROXIDE OF HYDROGEN FOR THE RELIEF OF BITES 
FROM VENOMOUS INSECTS. 
Dr. Philippe Ricord, of Newark, N. J., writes: 
" Recently, while charging my atomizer with the full strength of fresh standard 
Marchand's preparation of Peroxide of Hydrogen, at the bedside of a child suffering 
with diphtheria, my attention was attracted by the patient's mother, who appeared in 
pain, and stated that while taking up a blanket to wrap about her child she supposed 
she had been pricked by a needle, and on further examination discovered a hornet 
between the folds she had touched. Thereupon I immediately directed the Peroxide 
of Hydrogen spray into the wound, the surrounding tissues, in the few seconds that 
had elapsed, being swollen to such an extent as to distinctly mark its site. Instantly 
all pain ceased, and the swelling rapidly disappeared. In this case the wound was 
still sufficiently open to readily admit the Peroxide of Hydrogen, and the destruction 
of the virus was apparently in a moment so completely accomplished that no further 
treatment was afterwards required. May we not, therefore, infer that it is quite 
possible to annihilate many other poisons, likewise, by the prompt application of so 
powerful yet safe an agent as the Peroxide of Hydrogen?" 
(Page 148, New York Medical Record, February 8, 1890.) 55 
THE NECESSARY PEROXIDE OF HYDROGEN. 
Read in the Section of Surgery and Anatomy, at the Forty-first Annual Meeting of 
the American Medical Association, held at Nashville, Tenn., May, 1890. 
By ROBERT T. MORRIS, M.D., of New York. 
Published by the Journal of the American Medical Association, Chicago, August 9th, 
1890, page 216. 
Stop suppuration ! That is the duty that is imposed upon us when we fail to pre- 
vent suppuration. 
As the ferret hunts the rat, so does Peroxide of Hydrogen follow pus to its narrowest 
hiding place, and the pyogenic and the other micro-organisms are as dead as the rat 
that the ferret catches when the Peroxide is through with them. Peroxide of Hydro- 
gen, H2O2, in the strong 15-volume solution, is almost as harmless as water ; and yet, 
according to the testimony of Gifford, it kills anthrax spores in a few minutes. 
For preventing suppuration we have bichloride of mercury, hydronaphtol, carbolic 
acid, and many other antiseptics; but for stopping it abruptly, and for sterilizing a 
suppurating wound, we have only one antiseptic that is generally efficient, so far as I 
know, and that is the strong Peroxide of Hydrogen. 
Therefore I have qualified it, not as "good," not as " useful," but as " necessary." 
In abscess of the brain, where we could not thoroughly wash the pus out of tortuous, 
canals without injuring the tissues, the H2O2 injected at a superficial point will follow 
the pus, and throw it out, too, in a foaming mixture. It is best to inject a small quan- 
tity, wait until foaming ceases, and repeat injections until the last one fails to bubble. 
Then we know that the pus cavity is chemically clean, as far as live microbes are 
concerned. 
In appendicitis, we can open the abscess, inject Peroxide of Hydrogen, and so 
thoroughly sterilize the pus cavity that we need not fear infection of the general peri- 
toneal cavity, if we wish to separate intestinal adhesions and remove the appendix 
vermiformis. Many a patient, who is now dead, could have been saved if Peroxide of 
Hydrogen had been used when he had appendicitis. 
The single means at our disposal allows us to open the most extensive abscess psoas 
without dread of septic infection following. 
In some cases of purulent conjunctivitis, we can build a little wall of wax about 
the eye, destroy all pus with Peroxide of Hydrogen, and cut the suppuration short. 
Give the patient ether, if the H2O3 causes too much smarting. It is only in the eye, 
in the nose and in the urethra that Peroxide of Hydrogen will need to be preceded by 
cocaine (or ether) for the purpose of quieting the smarting, for it is elsewhere almost 
as bland as water. 
It is possible to open a large abscess of the breast, wash it out with H2O2, and 
have recovery ensue under, one antiseptic dressing, without the formation of another 
drop of pus. 
Where cellular tissues are breaking down, and in old sinuses, we are obliged to 
make repeated applications of the H2O2 for many days, and in such cases I usually 
follow it with balsam of Peru, for balsam of Peru, either in fluid form or used with 
sterilized oakum, is a most prompt encourager of granulation. 
If we apply H2O2 on a probang to diphtheritic membranes at intervals of a few 
moments, they swell up like whipped cream and come away easily, leaving a clean 
surface. The fluid can be snuffed up into the nose and will render a foetid ozcena. 
odorless. 56 
It is unnecessary for me to speak of further indications for its use, because wher- 
over there is pus we should use Peroxide of Hydrogen. We are all familiar with the 
•old law "Ubipus, ibi evacua," and I would change it to read " Ubi pus, ibi evacua, 
ibi hydrogenuni peroxidum inf unde." That is the rule The exceptions which prove 
the rule are easily appreciated when we have them to deal with. 
Peroxide of Hydrogen is an unstable compound, and becomes weaker as oxygen is 
given off, but Marchand's 15-volume solution will retain active germicidal 
power for many months if kept tightly corked in a cold place. The price of 
this manufacturer's preparation is about 75c per lb., and it can be obtained from any 
large drug house in this country. When using the H2O2 it should not be allowed to 
come into contact with metals if we wish to preserve its strength, as oxygen is then 
given off too rapidly. 
H2O2 must be used with caution about the hair, if the color of the hair is a matter 
of importance to the patient: for this drug, under an alias, is the golden hair bleach 
of the nymph's despare, and a dark-haired man with a canary-colored moustache is a 
■stirring object. 
PEROXIDE OF HYDROGEN AND OZONE. 
THEIR ANTISEPTIC PROPERTIES. 
"Read before the International Medical Congress, held at Berlin, Germany, on the 7th 
of August, 1890. Published by Medical News of Philadelphia, October 25th, 
1890. Pp. 416-418. 
By Dr. PAUL GIBIER, Director of the Pasteur Institute of New York. 
dENTLEMEN : 
Since the discovery of Peroxide of Hydrogen by Thenard, in 1818, the therapeut- 
ical applications of this oxygenated compound seem to have been neglected both by the 
medical and the surgical professions; and it is only in the last twenty years that a few 
bacteriologists have demonstrated the germicidal potency of this chemical. 
Among the most elaborate reports on the use of this compound may be mentioned 
those of Paul Bert and Regnard, Baldy, Pean and Larrive. 
Dr. Miguel places Peroxide of Hydrogen at the head of a long list of antiseptics, 
and close to the silver salts. 
Dr. Bouchut has demonstrated the antiseptic action of Peroxide of Hydrogen, 
when applied to diphtheritic exudations. 
Prof. Nocart, of Alfort, attenuates the virulence of the microbe symptomatic of 
carbuncle, before he destroys it, by using the same antiseptic. 
Dr. E. R. Squibb,1 of Brooklyn, has also reported the satisfactory results which 
he obtained with Peroxide of Hydrogen in the treatment of infectious diseases. 
Although the above-mentioned scientists have demonstrated by their experiments 
that Peroxide of Hydrogen is one of the most powerful destroyers of pathogenic 
microbes, its use in therapeutics has not been as extensive as it deserves to be. 
In my opinion the reason for its not being in universal use is the difficulty of 
procuring it free from hurtful impurities. Another objection is the unstableness of the 
compound, which gives off nascent oxygen when brought in contact with organic 
substances.2 
1 Gaillard's Medical Journal, March, 1889. 
2 The Peroxide of Hydrogen that I use is manufactured by Mr. Charles Marchand, of New York. 
This preparation is remarkable for its uniformity in strength, purity and stability. 57 
Besides the foregoing objections the surgical instruments decompose the peroxide, 
hence, if an operation is to be perfonned, the surgeon uses some other antiseptic during 
the procedure, and is apt to continue the application of the same antiseptic in the sub- 
sequent dressings. 
Nevertheless, the satisfactory results which I have obtained at the Pasteur Insti- 
tute of New York with Peroxide of Hydrogen, in the treatment of wounds result- 
ing from deep bites, and those which I have observed at the French clinic of 
New York, in the treatment of phagedenic chancres, varicose ulcers, parasitic 
diseases of the skin, and also in the treatment of other affections caused by germs, 
justify me in adding my statement as to the value of the drug. 
But, it is not from a clinical standpoint that I now direct attention to the anti- 
septic value of Peroxide of Hydrogen. What I now wish is merely to give a full 
report of the experiments which I have made on the effects of Peroxide of Hydrogen 
upon cultures of the following species of pathogenic microbes : Bacillus anthracis, 
bacillus pyocyaneous, the bacilli of typhoid fever, of Asiatic cholera, and of yellow 
fever, streptococcus pyogenes, micro-bacillus prodigiosus, bacillus megaterium, and 
the bacillus of osteomyelitis. 
The Peroxide of Hydrogen which I used was a 3.2% solution, yielding fifteen 
times its volume of Oxygen ; but this strength was reduced to about 1.5#, correspond- 
ing to about eight volumes of Oxygen, by adding the fresh culture containing the 
microbe upon which I was experimenting. I have also experimented upon old cultures 
loaded with a large number of the spores of the bacillus anthracis. In all cases 
my experiments were made with a few cubic centimetres of culture in sterilized test- 
tubes, in order to obtain accurate results. 
The destructive action of Peroxide of Hydrogen, even diluted in the above pro- 
portions, is almost instantaneous. After a contact of a few minutes, I have tried to 
cultivate the microbes which were submitted to the peroxide, but unsuccessfully, 
owing to the fact that the germs had been completely destroyed. 
My next experiments were made on the hydrophobic virus in the following 
manner : 
I mixed with sterilized water a small quantity of the medulla taken from a rabbit 
that had died of hydrophobia, and to this mixture added a small quantity of Peroxide 
of Hydrogen. Abundant effervescence took place, and, as soon as it ceased, having 
previously trephined a rabbit, I injected a large dose of the mixture under the dura 
mater. Slight effervescence immediately took place and lasted a few moments, 
but the animal was not more disturbed than when an injection of the ordinary virus 
is given. This rabbit is still alive, two months after the inoculation. 
A second rabbit was inoculated with the same hydrophobic virus which had not 
been submitted to the action of the peroxide, and this animal died at the expiration 
of the eleventh day with the symptoms of hydrophobia. 
I am now experimenting in the same manner upon the bacillus tuberculosis, 
and if I am not deceived in my expectation, I will be able to impart to the profession 
some interesting results. 
It is worthy of notice that water charged, under pressure, with fifteen times its 
volume of pure oxygen has not the antiseptic properties of Peroxide of Hydrogen. 
This is due to the fact that when the peroxide is decomposed nascent oxygen 
separates in that most active and potent of its conditions next to the condition, 
or allotropic form, known as "Ozone." Therefore it is not illogical to conclude that 
ozone is the active element of Peroxide of Hydrogen. 
Although Peroxide of Hydrogen decomposes rapidly in the presence of organic 
substances, I have observed that its decomposition is checked to some extent by the 
addition of a sufficient quantity of glycerin ; such a mixture, however, cannot be kept 58 
for a long time, owing to the slow but constant formation of secondary products, 
having irritating properties. 
Before concluding I wish to call attention to a new oxygenated compound, or 
rather ozonized compound, which has been recently discovered and called "Glycozone" 
by Mr. Marchand. 
This Glycozone results from the reaction which takes place when glycerine is 
exposed to the action of ozone under pressure-one volume of glycerine with fifteen 
volumes of ozone produces Glycozone. 
By submitting the bacillus anthracis, pyocyaneous, prodigiosus, and megaterium 
to the action of Glycozone, they were almost immediately destroyed. 
I have observed that the action of Glycozone upon the typhoid fever bacillus, and 
some other germs, is much slower than the influence of Peroxide of Hydrogen. 
In the dressing of wounds, ulcers, etc., the antiseptic influence of Glycozone is 
rather slow if compared with that of Peroxide of Hydrogen, with which it may, 
however, be mixed at the time of using. 
It has been demonstrated in Pasteur's laboratory that glycerine has no appreciable 
antiseptic influence upon the virus of hydrophobia ; therefore, I mixed the virus of 
hydrophobia with glycerine, and at the expiration of several weeks all the animals 
which I inoculated with this mixture died with the symptoms of hydrophobia. 
On the contrary, when glycerine has been combined with ozone to form Glyco- 
zone, the compound destroys the hydrophobic virus almost instantaneously. 
Two months ago, a rabbit was inoculated with the hydrophobic virus, which had 
been submitted to the action of this new compound, and the animal is still alive. 
I believe that the practitioner will meet with very satisfactory results with the use 
of Peroxide of Hydrogen for the following reasons : 
I. This chemical seems to have no injurious effect upon animal cells. 
2. It has a very energetic destructive action upon vegetable cells-microbes. 
3. It has no toxic properties ; five cubic centimetres injected beneath the skin of 
a guinea-pig do not produce any serious result, and it is also harmless when given by 
the mouth. 
As an immediate conclusion resulting from my experiments, my opinion is, that 
Peroxide of Hydrogen should be used in the treatment of diseases caused by germs, 
if the microbian element is directly accessible ; and it is particularly useful in the 
treatment of infectious diseases of the throat and mouth. 
HYDROGEN PEROXIDE IN DIPHTHERIA. 
Extract from the New York Medical Journal, December 6, 1890.) 
1189 xfadison Avenue, November S, 1890. 
To THE Editor of the Nev> York Medical Journal: 
Sir :-I would suggest the following local treatment for diphtheria : The applica- 
tion to the membrane of Marchand's solution of Peroxide of Hydrogen, fifteen volumes, 
with an equal bulk of water, then scraping the membrane off with a curette and apply- 
ing the Peroxide of Hydrogen, one-third dilution, every hour for six or seven hours, 
then every two hours If there is no reappearance of membrane after two days, spray 
the throat occasionally with an antiseptic spray. In this way the membrane is 59 
removed at once. The operation is done at a period of the disease when there is no 
danger of heart failure, so that the struggles of a child need not be minded. 
I am aware that the removal of the membrane in former years was regarded as 
somewhat dangerous, but at that time nothing was known of disinfectants and germi- 
cides. 
It would seem that a remedy which, applied to the diphtheritic membrane, 
removed it after some hours, would prevent its formation. In tolerant patients the 
peroxide may be put on three or four times so as to be sure of complete disinfection 
before curetting. A small Thomas's uterine curette answers the purpose admirably. 
A patient treated as described was comparatively well in two days. 
David Phillips, M.D. 
PEROXIDE OF HYDROGEN. 
(Extract from Medical Summary, December, 1890. Page 214.) 
After trying for the past five years innumerable therapeutic agents for my lupus 
or epithelioma, I was advised by Dr. Cutter, a celebrated microscopist and scientist of 
New York, to spray the ulcer with the peroxide and afterwards apply cotton saturated 
with the same. I used three different local applications, aristol, Howe's salve, and 
the peroxide ; marked the cotton and sent the same to him. 
He reported the best results from the peroxide and advised its continuance. 
Though it did not kill the sporesit made them inactive, while no perceptible difference 
could be seen upon them from the other two. This peroxide bore the initials P. & W., 
our noted Philadelphia chemists. Seeing Marchand's advertisement in the Summary, 
I concluded to try his, and sent for some. He kindly included in the order his glyco- 
zone to use in conjunction with the peroxide. A marked change was the result. The 
sore looked better, cleaner, healthier, and upon examination of the cotton, Dr. C. 
wrote me to continue the use of Marchand's. Here was a decided test and in favor of 
Ch. Marchand's. The ulcer has steadily progressed for the better. * * * * 
Yardley, Pa. 
A. Livezey, M.D. 
HYDROGEN DIOXIDE; A RESUME. 
JOHN AULDE, M.D., of Philadelphia. 
Member of the American Medical Association, of the Medical Society of the State of Pennsylvania* 
of the Philadelphia County Medical Society, etc. 
(Published by the New York Medical Journal, December 27, 1890.) 
Within the past ten years the use of hydrogen dioxide (peroxide of hydrogen) has 
become quite general among practitioners whose business has led them to give special 
attention to some particular class of disorders. Many general practitioners, however, 
have not availed themselves of the benefit afforded by this comparatively recent addition 
to our therapeutic resources, owing to the expense and the care required in looking 
after details, together with the uncertainty which attended its employment. These 
difficulties no longer exist; but, when we consider the advantages to be gained from its 60 
use, the process of evolution has been remarkably slow, notwithstanding the sporadic 
attempts which have been made to attract the attention of the medical profession. 
Novel methods of treatment are too frequently shunned without investigation by 
regular physicians, while, on the contrary, these innovations are readily adapted to 
the wants of the quack. 
In the present instance, although the furore for antiseptics continues unabated, 
the true position of oxygen has been ignored by those who should have given it their 
first attention. Long-continued and persistent effort has erected an imposing 
superstructure upon a theoretical foundation, losing sight of the marvelous influences 
constantly at work in nature. The corner-stone of this ornate edifice originally 
adopted was carbolic acid ; the pilasters which gave strength and beauty to its walls 
were composed of carbolated gauze, while cornice and roof were made of protective 
which had been submitted to a carbolizing process. This highly flavored substance 
has given place to a number of others, some of which are safer, but no more useful ; 
others are more efficient than carbolic acid, but, as usually employed, are far more 
dangerous. As the foundation for asepsis rests upon absolute cleanliness, so the 
foundation for antisepsis must rest upon an equally safe basis as regards the patient. 
The only agent known at the present time which fully meets our requirements is 
oxygen in some of its forms. While the spores of anthrax bacilli resist our most 
poisonous products-such as solutions of hydrochloric acid (two per cent.), boric and 
salicylic acids in concentrated solutions-oxygenated water alone, in sufficient quantity, 
was shown by Paul Bert and Regnard to possess the power of destroying the bacteria. 
The wonderful properties of ozone are but partly understood ; like some other 
powerful agents, it cannot be safely handled, but it gives great promise of usefulness 
in the future. The statement has been made that ozone is but an allotropic form of 
oxygen, and that it is identical with hydrogen dioxide (the subject of the present 
article), and for all practical purposes, from a therapeutic standpoint, they may be 
considered substantially the same. Having, then, at our command a remedy 
possessing such remarkable properties as a bactericide, one which is perfectly harmless 
when brought into contact with healthy tissues, it will be worth while to study the 
indications for its use in the treatment of disease. In the first place, however, I 
should say a word with reference to the causes which have contributed to prevent its 
universal employment by physicians-causes already referred to incidentally. * * * 
3. The uncertainty following the employment of the peroxide has arisen from 
various causes, and, as this is a subject of paramount importance, the items will be 
considered in detail. In the pure state hydrogen peroxide is exceedingly unstable, 
and, in order to render it less susceptible to the action of heat, which causes it to part 
with nascent oxygen rapidly, minute quantities of hydrochloric and phosphoric acids are 
added to the usual fifteen-volume solution ; but this, instead of retarding, rather 
heightens the effect of the remedy when applied to unhealthy structures, especially 
mucous surfaces. When the container is allowed to remain in a warm room, or when 
it is not properly stoppered, the activity of the preparation is materially lessened, if 
not entirely lost. An excess of acid is objectionable, however, as it renders the 
peroxide irritating instead of soothing. 
Commercial peroxide which is used extensively for bleaching purposes and in the 
arts, is doubtless responsible for unsatisfactory results, but, as compared with the 
medicinal preparation, it is a very inferior product, sold at a cost of about eight cents 
a pound. Physicians should know that this product always contains a large proportion 
of acids (two to five per cent.), hydrofluoric, sulphuric, hydrochloric, oxalic, and nitric 
acids, and, knowing this to be the case, they should be careful to examine the 
reactions and see that the medicinal preparation obtained by patients is supplied in 
original packages. The commercial product is not " just as good " nor will it "do as 
well" for the patient ; and if these suggestions are kept in view, the success of the 
peroxide is assured. 
Another important thing which I have learned is, that the mixture of the peroxide 
with glycerin does not make rt glycozone," but, instead, a mixture which generates 61 
slowly but constantly secondary products, which appear to possess irritating properties 
almost as toxic as those of formic acid, well known in Central Africa as a deadly 
arrow poison. I am of the opinion also that when the peroxide is used in the form of 
an inhalation by heating with water, a considerable proportion of the nascent oxygen is 
transformed into ordinary oxygen before reaching the affected tissues, and while I can 
readily understand how this must detract from its efficiency, remarkably prompt results 
have attended its administration in this manner. The only obstacle in the way of 
securing immediate and favorable results from the exhibition of this agent is our 
inability to command at all times a freshly prepared and thoroughly reliable product, 
free from the impurities incident to its manufacture ; but that difficulty, I believe, is 
no longer an excuse, as it can be supplied by the principal druggists throughout the 
•country. * * * 
Therapeutics-From the peroxide of hydrogen we may obtain, in the form of a 
■vapor or spray, the therapeutic effects of nascent oxygen, and as a surgical application 
or antibacterial substance this product is far superior to the gas itself. Used in the 
form of a vapor by inhalation, it increases the secondary assimilation by favoring the 
elimination of excrementitious products through the stimulating effect upon internal 
respiration. Just as pure mountain air arouses the activity of functions which have 
been depressed and promotes health, so oxygen evolved in this manner increases tissue 
change and prevents the suboxidation which attends upon the arrest of cell function. 
Oxygen is a tissue builder as well as an oxidizer of carbonaceous and excrementitious 
products. When it is introduced into the alimentary tract, abdominal fermentations 
are arrested by the destruction of the germs which produce them ; unhealthy mucous 
secretions are destroyed, while the vitality of the cells lining the walls of the intestine 
is augmented, and their power against the absorption of ptomaines and leucomaines 
greatly increased. The surgeon will find the peroxide an efficient and most convenient 
antiseptic, as it can be freely used in cavities, in discharging sinuses, and upon the 
most delicate tissues, without danger of producing the slightest irritation. In all 
cases of threatened collapse, in low conditions of the system, and during convalescence 
from severe illness, the physician should bear in mind the wonderful revitalizing 
properties of this remedy. Perhaps the reader will gain a more practical idea of the 
applications by a reference to some of the more prominent indications, and I shall 
briefly pass in review some of the diseases in which it may be used with beneficial 
results. * * * 
Since it has been determined that in yellow fever and cholera the poison germ is 
found only in the intestine, the peroxide promises to afford exceptional relief in these 
diseases. When it is introduced into the rectum, the beat of the body will cause 
oxygen gas to be evolved, while the local action of the drug will destroy all unhealthy 
products which may be present in the lower bowel. The nascent oxygen will be taken 
up by the absorbent structures and enter the general circulation ; but if we accept the 
doctrine of phagocytosis, it will do even more than this, by reason of its stimulating 
action upon the modified white corpuscles, which are now regarded as the special 
enemies of bacteria escaping through the walls of the intestines. And for the same 
reason it may be used with advantage as a lavement in the treatment of diarrhoea, 
dysentery, and in typhoid fever. In the latter disease I have used the pure oxygen 
gas with very great satisfaction, and have found a solution of the peroxide superior as 
a mouth wash during the progress of this most tedious disorder. 
The peroxide should be used in all forms of indigestion, and more especially when 
the stomach is weak and depressed to such an extent that the usual antiseptics are not 
well tolerated. Those who use it once for the relief of indigestion, gastritis, gastralgia, 
and for the arrest of fermentation, or an abnormal flow of mucous, will have no cause 
to regret the selection. A large number of cutaneous affections are dependent upon an 
unhealthy condition of the alimentary tract, such as urticaria, eczema, etc., and, of 
course, are benefited by the use of the peroxide. 62 
Pulmonary affections have long claimed the attention of those who dabbled 
with oxygen inhalations, and it is in this class of cases where faithful attention to 
details will produce most marked effects, although I can not be convinced that any 
medicament in itself can arrest the progress of the disease. The continued use of the 
peroxide internally improves the primary assimilation ; the regular and systematic 
inhalation of the vapor will not only improve the secondary assimilation, but will also 
destroy any morbid products with which it comes into contact in the pulmonary tissues, 
and, judging from my own experience with this agent, I have no hesitancy in saying 
that its value is not yet appreciated by a large number of physicians who, with it, 
might be the means of prolonging human life. My observations with the vapor and 
spray in asthmatic conditions have been surprising, and I have found them of signal 
service in meeting emergencies, such as asphyxia from coal gas, sudden collapse from 
hemorrhage, typhoid and other fevers. The long continued use of the vapor has a 
marked effect in restoring the resiliency of the air-vesicles in emphysema when it 
occurs along with asthma in young persons. A gentleman now under treatment has 
suffered from asthma since he was six weeks old, and is now twenty-five, but under 
this treatment he has gained weight, is able to sleep regularly every night, and has 
increased sixteen pounds in weight during the past three weeks, while the chest 
measurement has appreciably decreased. This method of treatment is valuable in 
phthisis at all stages, but it should be used as an adjuvant to other treatment and 
attention given to diet. In this connection should be mentioned the usefulness of the 
vapor in the treatment of bronchitis, subacute and chronic, and at the same time the 
value in aborting attacks of acute catarrh. 
Inhalations of the vapor will prove useful as an adjuvant in neuralgia, anaemic 
headaches, general debility, malarial toxaemia, and corpulence, combined with diet 
adapted to the various disorders mentioned. 
In surgical practice, when the solution of the proper strength is brought into 
contact with diseased tissues, a brisk effervescence takes place and continues until all 
the pus-corpuscles present are destroyed. This solution may be used topically in 
nearly all cases of catarrh of the upper air passages in the form of a spray, and it may 
be used as an antiseptic after the removal of pus in empyema. The substance 
possesses the advantage over other antiseptics of being harmless, and can therefore be 
used freely in diphtheria and croup. There are so many indications for its employment 
that it would be difficult to mention all the topical uses, although the following may be 
referred to, viz., boils, carbuncles, indolent ulcers, carcinoma, and venereal diseases 
as an injection. 
The gynaecologist will find numerous applications for this agent. It may be used 
in the form of a douche in leucorrhoea, elytritis, and vaginismus, and a cotton-wool 
tampon may be saturated with it and placed in a gelatine capsule (veterinary size) and 
introduced into the vagina in the case of ulceration, vesico-vaginal fistula, and 
endometritis. The ophthalmologist and aurist will likewise find that it furnishes them 
the most complete and safe antiseptic that can be had, and gradually its employment 
will extend to every department of medicine and surgery. 
The most flattering commendations of " Marchand's Peroxide of Hydrogen 
(medicinal)" have been given voluntarily by numerous well-known authors and 
contributors to medical literature within the past few years, some of whom may be 
mentioned as additional evidence that the methods here recommended are woithy of 
further investigation : Dr. W. B. Clarke, of Indianapolis, Ind.; Dr. George B. Hope, 
Surgeon to the Metropolitan Throat Hospital, New York ; Dr. J. Mount Bleyer, of 
New York ; Dr. Robert T. Morris, of New York ; Dr. Paul Gibier, Director of the 
New York Pasteur Institute; Dr. R. Charest, of St. Cloud, Minn.; Dr. E. R. 
Squibb, of Brooklyn, N. Y.; and others whose names cannot now be recalled. 
Dr. Morris refers to it as "the necessary peroxide of hydrogen," and I have found 
Marchand's product to possess in a remarkable degree the properties so essential to- 
success-viz., uniformity in strength, purity, and stability. 63 
PEROXIDE OF HYDROGEN IN GYNECOLOGY 
AND IN OBSTETRICS. 
■Obstetric Stirgeon New York Maternity Hospital, Visiting Obstetrician New York 
Infant Asylum, etc. 
EGBERT H. GRANDIN, M.D., 
Modern methods of antisepsis enable us in the vast proportion of cases to prevent 
suppuration. The problem remaining is how arrest it when present, or abort it when 
imminent. 
The virtues of peroxide of hydrogen (Ha O2) in general surgical practice have 
recently been heralded by Dr. Robert T. Morris, of this city, in the columns of The 
Times and Register * The object of the writer is to exemplify his personal experience 
with this agent, through the brief record of a few cases in which he has tested it. 
Case 1. Sub-mammary abscess.-About one year ago I was consulted by a Mrs. 
G. She was nursing a two and a half months' puny infant, notwithstanding the fact 
that the right mamma was fairly riddled with sinuses, and the left presented to my 
touch faint fluctuation. Her previous medical attendant had exhausted all routine 
measures, and yet, as she expressed it, " she was going from bad to worse." She had 
hectic fever and other symptoms of sepsis ; her appearance suggested the absolute 
necessity of rapid action. 
I at once weaned the child, of course ; made a deep incision in the left mamma, 
giving exit to a mass of fetid pus, washed out the cavity with bichloride (1-1,000), and 
packed it with gauze. I thoroughly wetted the sinuses in the right mamma, irrigated 
and packed them similarly. In a few days 1 had control of the sepsis, but the 
pyogenic membrane and its product resisted all my efforts. In despair, and without 
much hope of success, I washed out the cavities with peroxide of hydrogen (half 
diluted with glycerine), and applied a compression gauze bandage. At the end of ten 
days the abscesses were cured. 
Case II. Suppurating pelvic hematocele.-This case was seen in consultation. 
The patient was a young prostitute, and the only etiological cause I could determine 
was copulation during menstruation. The tumor bulged in the retro-uterine pouch, 
and I treated it as follows: Under antiseptic irrigation I aspirated along the finger 
as a guide, and obtained a mixture of blood and pus. Using the aspirator muzzle as 
a director, I enlarged the opening transversely, sufficiently to admit a Palmer dilator. 
Inserting this I divulsed, curetted the cavity-which measured fully three inches 
square-and washed it out with equal parts compound tincture of iodine and water. 
I next inserted a flange-rubber drain tube. The cavity was washed out daily through 
this tube with two and one-half per cent, carbolic, but contrary to my experience with 
similar cases, it had not contracted much at the end of a week, and was still secreting 
pus. I then inserted a small Chamberlain glass uterine tube, and distended the 
cavity with undiluted peroxide of hydrogen. This checked suppuration at once, and 
when the patient was seen three weeks thereafter, an induration in the posterior 
vaginal cul-de-sac was the only remnant of the hematocele. 
Case III. Puerperal septic endometritis.-Seen in consultation. Fifth day 
post-partum. Patient had foetid lochia, tenderness over uterus, rise of temperature, 
rapid pulse. A number of intra-uterine bichloride douches had been administered 
before I saw the case. Having differentiated extra uterine source of the general 
^sepsis, I curetted the cavity of the uterus, according to the method I have repeatedly 
-described and advocated, removing a mass of degenerated decidual matter, and then, 
(Published by The Times and Register, of Philadelphia, January 31, 1891.) 
*Seep. 55, reprint of article headed "The Necessary Peroxide of Hydrogen," 
by Dr. Robert T. Morris. 64 
instead of applying pure phenic acid to the cavity, and irrigating it with iodine and 
water, I washed it out through a Chamberlain glass tube with a pint of peroxide of 
hydrogen (undiluted). The local sepsis was thus at once checked ; the patient made 
a rapid convalescence under the means which suggest themselves for meeting the 
sepsis already in the system. 
These cases typify instances in which the peroxide of hydrogen will be found 
useful by the gynecologist and obstetrician. As opportunity offers I propose to resort 
to this agent in vaginitis, urethritis, and purulent cystitis. Further, and in this- 
direction I am as yet only experimenting, I am hopeful that in this agent we will 
find we possess a means which will enable us to avoid laparotomy in certain instances 
of pyosalpinx. My conclusions on this point, however, it would be premature to 
state. 
My experience thus far with the peroxide of hydrogen justifies the statement that 
it is absolutely harmless, and that it is at the same time the most efficient of all the 
agents at present at our disposal for preventing the ravages which uncontrolled 
suppuration is capable of causing. 
SINUS TREATED WITH PEROXIDE OF HYDROGEN. 
(Extract from Practice, Richmond, Va., February, 1891.) 
Dr. William F. Waugh tells in the Times-Register of an old woman who stepped 
on a nail, which penetrated the foot almost to the superior surface. A sinus formed, 
and had been discharging for two months when the patient was first seen. Marchand's- 
peroxide of hydrogen was injected into the sinus by means of a hypodermic syringe. 
The first effect was to destroy the leather of the piston. The sinus was found to be 
of a horse-shoe shape, the probe passing almost through the foot, between the meta- 
tarsal bones, and when the peroxide was injected a hard lump could be felt one inch 
from the opening on the sole of the foot. This was laid open, and a stream of pero- 
xide was sent through. Result : Cured in a week. 
DIPHTHERIA AND THE USE OF HYDROGEN DIOXIDE 
IN ITS TREATMENT. 
Read before the Chemical Society of Maryland, February 6, /8g/. 
By Dr. EDW. J. BERNSTEIN, of Baltimore. 
In this very elaborate paper, Dr. E. J. Bernstein says : (p. 361). . . In my 
first case of diphtheria I began the use of Sulphide of Calcium, but finding that not 
only was it disagreeable to both taste and smell, and that it also soiled the bed linen 
and clothing of the patient, but that the disease continued to get worse, that the 
membrane which at first was limited to large necrotic patches on the tonsils, now 
covered the entire anterior pillars of the fauces and the uvula, which was now 
considerably swollen. 
I discarded the nostrum and began the use of Hydrogen Dioxide, which I directed 
to be sprayed into the throat every hour of the day and night, gradually relaxing the 
number of night sprayings as the case went on to improvement. I also directed that 
the nose should be sprayed at least twice a day with the same solution. Within a few 
hours the mother said she noticed a change for the better in her child, and when I 
made my evening call it was quite perceptible. I also noticed, which fact I have since 
seen corroborated by others who had used the drug, the better color of the child. 
The lips, which before its administration were quite blue, were now of a healthy red 
color. The membrane in the throat had made no increase By the following morning 
(Extract from Maryland Medical Journal, February 21, 1891.) 65 
there was a decided decrease in the pseudo-membrane, and from now on began to 
disappear. 
In conjunction with the above local treatment, I gave large doses of tine, ferri 
chlo. in combination with tonic dose of quinia every three hours. 
Cream of tartar lemonade was given ad libitum to appease thirst and to relieve 
ccngestion. The air of the room was regularly charged with steam, generated on a 
small alcohol stove, to which had been added an alcoholic solution of menthol, 
eucalyptol and thymol. It is well to say that the strength of the hydrogen dioxide was 
50 per cent, of Ch. Marchand's 15-volume solution. 
In three other cases which came under my observation, I followed out the same 
line of treatment, and each recovered without any untoward after effects. In the hope 
that some of you here this evening may be induced to try this plan of treatment, I 
submit this paper. 
HYDROGEN PEROXIDE IN DIPHTHERIA. 
BV G. F. ADAMS, M.D., of Pulaski, N. Y 
(Published in the Medical Era of Chicago, Ill., March, 1891.) 
The article in the December "Era" copied from the "Medical Times," by Dr. George 
W. Major, in regard to the use of Peroxide of Hydrogen in diphtheria, I can heartily 
indorse. I have just discharged three cases of diphtheria that I treated with Ch. 
Marchand's Peroxide of Hydrogen. I sprayed the throat with an atomizer filled with 
full strength 15-volume solution of peroxide in the early stages. The membrane was 
removed almost at once, and after the first application and one complete clearing of 
the throat, I then reduced the 15-volume solution by adding three parts water to one 
of peroxide, and by spraying the throat thoroughly as often as once an hour, all 
membrane was destroyed, the breath was kept sweet, and the throat in a fairly 
comfortable condition. When used at first in full strength the patient may complain 
of a slight smarting, but no irritation results. 
The atomizer should consist of nothing but glass and rubber, as the peroxide has 
a strong affinity for all metals, except gold, silver, and the rare metals. 
I can assure all who try Peroxide of Hydrogen as a local application in diphtheria 
that they will be thoroughly well pleased with it. 
SCARLATINAL DIPHTHERIA. 
WM. F. WAUGH, M.D. 
(Extract from The Times and Register, Philadelphia, March 7, 189X.) 
I desire to place upon record a case that is unique in my own experience ; though 
my readers may, perhaps, have had better results. The case was that of a child under 
four years of age. He had been attended by a dispensary physician during the first 
part of the illness : and this gentleman, when he gave up the case, had given a gloomy 
prognosis, with which I heartily coincided. On my first visit I found the child's throat 
covered with blackish sloughs, the lips and tongue covered with fissures and ulcers, the 
nose discharging freely the irritating and offensive secretion of nasal diphtheria, the 
eyes showing spots of pus at the inner canthus. The child complained of earache and 
of pain in the forehead, so that the disease had passed up the Eustachian tubes and 
into the frontal sinuses. Reddish spots and blotches appeared on the face and bpdy. 
The stench was dreadful, the urine almost totally suppressed, but the few drops that 
were passed could not be saved for examination. The child had been delirious for 66 
some time, not being able to recognize his parents. The one good point was that his 
stomach retained milk fairly well. 
It has not been my good fortune to witness the recovery of many such cases. In 
fact, the more extended is my experience with diphtheria, the more I dread it; 
especially when it has become firmly established in the Schneiderian mucous membrane, 
and in the passages leading from the naso-pharynx. 
I felt it my duty to inform the parents that death was the only result to be 
expected ; and that they could be very thankful if their other children, six in number, 
should escape. 
However, I gave them a bottle of Marchand's Peroxide of Hydrogen, and directed 
them to syringe the nostrils and wash the mouth out with the solution diluted to one- 
fourth its strength. This was repeated every hour, day and night. No other treatment 
was employed, and whiskey was given with the milk, as the only food. The child 
began at once to improve ; the right tympanic membrane gave way, and then the 
solution was thrown into the ear, and bubbled out at the nose. The urine began to 
be secreted more freely , and the child was pronounced out of danger in one week from 
my first visit. 
One of the other children was seized with sore throat, enlarged tonsils and 
torticollis ; another had a mild attack of scarlatina, but the others escaped without 
contracting the disease. This in itself is notable, as the children were all kept at 
home, in a crowded little house, with miserable sanitation. 
THE PEROXIDE OF HYDROGEN-ITS USES IN 
ABDOMINAL SURGERY. 
By CHARLES P. NOBLE, M.D., 
Surgeon-in-Charge of the Kensington Hospital for Women, Philadelphia. 
(Published by Philadelphia Medical News, April nth, 1891.) 
The importance of the Peroxide of Hydrogen as a germicide, and more especially 
as a pus-destroying agent, is becoming firmly established by "rapidly accumulating 
clinical evidence. A very considerable experience with the drug has made me enthu 
siastic concerning its remarkable qualities; and I find myself extending its application 
almost daily. In general, in order that antiseptic or germicidal agents may be used 
effectively, it is absolutely essential that all foreign material, discharges, etc., be first 
removed, so that the agent may be brought in direct contact with the surface or tissue 
to be acted upon. It is also true that the power of penetration of the antiseptics in 
common use is slight, so that they are reliable only in combating strictly superficial 
septic processes. This is particularly true of corrosive sublimate solution, which, by 
its action on albuminous discharges, forms an impenetrable covering which prevents 
the solution from coming in contact with the tissues to be acted upon. In this respect 
the action of the peroxide solution is essentially different. It attacks, disintegrates 
and oxidizes all discharges and dead tissue with which it comes in contact, thus.favor- 
ing its contact with and action upon underlying tissues. Moreover, the products of 
its activity escape as water and carbonic acid gas. At this time I do not propose to 
discuss the relative value of the peroxide of hydrogen as a germicide. I believe that 
our knowledge upon that subject will be far more exact after a little time than it is at 
present. The fact, however, that this agent has the power to oxidize dead organic 
matter suggests to my mind a wide field of usefulness for it in preventing saprsemia or 
ptomaine poisoning, in the treatment of suppurating tracks and cavities in which 
dependent drainage cannot be had, and in which free irrigation with water is imprac- 
ticable. 67 
In my work in abdominal surgery I have found Peroxide of Hydrogen of positive 
value. 
In cleaning the hands preparatory to operation I have found it very useful, 
especially when the skin about the finger-nails has become somewhat horny or rough- 
ened from too much use, or from frequent washings, or from prolonged contact with 
antiseptic solutions. Its power to loosen and to remove dead epithelial cells, and to 
soften the skin about the nails, is quite remarkable. Moreover, all foreign material 
about the nails is either oxidized and removed or is made more accessible to the 
sublimate solution which is used later. In practice I have used the peroxide after 
scrubbing my hands through three waters with soap and the nail-brush, then soaking 
them in turn in saturated solutions of permanganate of potassium and of oxalic acid, 
and before soaking them in corrosive sublimate solution. 
Bacteriological examinations have shown that even this method (omitting the 
peroxide solution) does not make asepsis certain, as germs have been removed from 
the subunguial spaces after it has been faithfully carried out. I have not been able to 
test the value of the addition of the peroxide of hydrogen solution in securing asepsis 
by bacteriological experiments, but practically I feel convinced that it is of service in 
securing that end. The settlement of the question authoritatively will be of great 
interest to all those who believe in satisfying an antiseptic conscience. 
In the management of the drainage-tube after abdominal section, under special 
conditions, the peroxide solution has been of signal service. In typical cases, in which 
the drainage tube is removed after from one to three days, there is no indication for its 
use. But when from any cause the drainage-tube must remain in longer, it is useful 
in keeping the tube and drainage track sweet and free from pus. On a number of 
occasions after a tube had been in place from a week to ten days, and the discharge 
had become slightly purulent, I have been able to combat successfully the tendency to 
suppuration, to shorten the tube gradually, finally to substitute a gauze plug for the 
glass tube, and to secure rapid healing of the drainage track; when otherwise a sinus 
would have resulted. One such case was one of a ruptured large ovarian tumor, 
having contents of a jelly-like consistency, which had become distributed throughout 
the peritoneal cavity. Jelly-like material was discharged through the tube for two 
weeks, and yet by the use of the peroxide solution rapid healing was obtained. 
Another case was one of post-operative intra-peritoneal hemorrhage. Tarry blood 
was discharged through the tube for ten days, yet the same care secured the same 
result. Another striking case was one of faecal fistula which formed after the removal 
of a dermoid ovarian cyst-presumably caused by the growth of a small bunch of hair 
from the cyst into the bowel. The track was kept clean and the peroxide was used 
freely. The faecal fistula closed in three weeks, and the remaining sinus closed within 
two months from the date of operation, being kept open for a time by an infected 
omental ligature, and closing promptly after its discharge. 
The peroxide solution has been applied to the drainage track and to the inside of 
the tube by saturating absorbent cotton, held in a slender long-handled forceps, and 
passing this down the tube. The peroxide solution has been used pure or diluted (one 
to two or three.) 
I have not used the peroxide solution within the peritoneal cavity during opera- 
tion, but believe it will prove useful in disinfecting infected pedicles. In removing 
pus sacs rupture frequently occurs, deluging the broad ligaments with pus. Under 
these circumstances the ligature applied to secure the pedicle necessarily becomes 
infected. Heretofore I have washed away septic material with boiled water, and 
later applied bichloride solution on a sponge to the region of the ligature. In such 
cases it seems probable that the peroxide solution will be of real value. 
In cleaning the abdominal wound preparatory to removing the sutures, the 
peroxide solution has proven very efficient; especially if a dry dressing-boric acid or 
iodoform-has been used. Finally, if any pus has formed in the track of the drainage- 
tube or of any of the sutures, the peroxide solution will remove it more efficiently than 
any other agent. A RESUME OF THE HISTORY AND PRACTICAL APPLI- 
CATION OF HYDROGEN PEROXIDE IN SURGICAL 
AFFECTIONS. 
S. POTTS EAGLETON, M.D. 
Resident Physician in the Children's Hospital, Philadelphia. 
{Medical and Surgical Reporter of Philadelphia, May 16, 1891.) 
Hydrogen peroxide was discovered by M. Thenard, a French chemist, in the year 
1818, since which time it has, like many other therapeutical remedies, lain dormant, 
occasionally being brought forward by some "enthusiast" and its virtues highly 
extolled for a time. But the drug, unequal to the task of proving all that had been 
said in its favor, was again and again returned to its stall of oblivion. Within the past 
few years, it has been brought before the medical profession, on account of its 
antiseptic properties, and apparently has awakened into active therapeutic life. 
In looking over the literature on the subject, I find that Dr. B. W. Richardson.1 
in 1802, called attention to the action of hydrogen peroxide in an article upon the 
subject, which excited wide spread interest in the profession at that time and has led 
to many experiments with the drug, both in surgery and medicine. 
It is my purpose to confine myself in this study entirely to the treatment of 
surgical affections. Before referring to the results of my own experience, during the 
past few months, I will briefly allude to some of the most important monographs which 
have appeared from time to time in our ifiedical journals. C. T. Kingzett2 believes 
that the substance exhibits striking antiseptic effects and is capable, even in very small 
quantities, of arresting the so-called process of fermentation which is originated by 
living organisms. He further calls attention to the fact that care should be exercised 
in making the solution neutral before using, and yet admits that neutral solutions are 
by no means as stable as are those of a slightly acid reaction. In closing his 
monograph he states that the expectations of several noted surgeons of France in the 
treatment of wounds with this compound have been amply realized ; among those 
may be mentioned M. Baldy, M. Regnard and M. Beau. In summing up his article 
he further says that, in his opinion, hydrogen peroxide is far superior to phenol, and 
that it has been demonstrated beyond question that all wounds treated with peroxide 
of hydrogen have progressed well, healing generally by first intention. 
A. E. Prince3 speaks most favorably of the results obtained with this remedy. 
C. E. Shelley4 considers it to possess anaesthetic properties, and at the same time 
claiming for the drug, not only a pus-destroyer, but that it is an actual stimulant to the 
surface of wounds. To the carefully conducted experiments of Dr. P. Miquel, quoted 
by W. D. Bizett,5 we owe the establishment, on a firm basis, of hydrogen peroxide as 
a positive germicide. The line of experimentation pursued had the following aim : to 
determine the quantity of various substances, commonly used as germicides, which, 
added to a quart of beef tea, would prevent decomposition. Miquel found among a 
1B. W. Richardson, Tr. M. Loc. Lond., 1862, vol. II, pp. 51-53. 
Vbid. 
SA. E. Prince, St. Louis, M. and S. Journal, 1884, vol. XLVI, pp. 246-252. 
4C. E. Shelley, Practitioner, Lond., 1884, vol. XXXII, p. 196, 
•W. D, Bizett, Atlanta M. and S. journal, 1888-9, N. S. 69 
long list of substances used by him, that only two were more powerful than hydrogen 
peroxide. The following table shows the relative strength, according to his experi- 
ments, of the four most powerful germicides : 
Biniodide Mercury 9.025 grains. 
Biniodide Silver 0 03 grains. 
Hydrogen Peroxide 0.05 grains. 
Bichloride Mercury 0.07 grains. 
The results thus obtained place hydrogen peroxide ahead of bichloride mercury 
as a germicide, with the advantage, also, of being absolutely void of any toxic action, 
while the corrosive sublimate is a most virulent poison, Bizett1 claims that when the 
pure peroxide, which is syrupy in consistence, is brought into contact with living 
tissues, it acts as a direct caustic. Various experiments were made by H. Gifford1 
directly with the disease germs, thus testing the germicidal action of the peroxide. 
Two methods of determining its ability to destroy germs, were used, that of Koch, and 
his own well-known method. The preparation of peroxide used, was that of Chas. 
Marchand's (15 vol.). Gifford found that the white and yellow cocci, as well as the 
bacilli anthrax, were killed in exposures of from J to H minutes. It required but f of a 
minute to destroy fully developed anthrax spores. He further found that the solution 
exposed for 40 days, to a temperature of 68-75° killed the yellow pus cocci in from 
10-11 minutes. The same solution of peroxide, when diluted with four times its bulk, 
requires an exposure of 30 minutes to kill the pus cocci. If diluted with an equal 
volume, it kills within f minute. After an experience of six months, I. N. LoveS; 
sums up the action of hydrogen peroxide as follows : It is a most efficient means of 
cleansing purulent surfaces, deep cavities and sinuses, stimulating the healthy process- 
in ulcerating parts. As a destroyer of microbes, a cleanser and securer of comfort, it 
is of great value as a local application. 
My own experience with this drug in surgical affections, during the past ten 
months, has been most satisfactory. During that time I have used the remedy in the 
following affections : Abscesses (acute and chronic, of various kinds), suppurating 
glands, sloughing gangrenous wounds, empyema of the chest, necrosis (general and 
localized), suppurative otitis media, and wounds of all descriptions. The ages of the 
cases treated, varied from two to thirteen years. The mode of applying the peroxide 
was as follows : All cavities, crevices, etc., were syringed with the bichloride of 
mercury (1-2000, to 1-6000) and then carefully cleansed with the hydrogen peroxide 
(Marchand's). 
At first one volume of this solution was diluted with two to three times its bulk. 
Later on, I used the full strength. The first effect noticed after applying the 
peroxide, was the rapid oxidation of all purulent or bloody material, which would 
cause the distention of crevices, no matter how minute, with the oxygen, which was 
eliminated as a frothy (often yellowish, depending upon the quantity of pus present)' 
bubbling substance. After the oxidation was completed, the wound was always left 
in a clean, sweet condition, absolutely free from pus. The wounds were then gently 
dusted over with iodoform and the usual antiseptic dressings of gauze, etc., were 
applied. On removal of the dressings, a few days later, it was noticed that the 
wounds were in almost every instance cleaner (especially marked in acute cases), more 
healthy in appearance and with a decided diminution in the quantity of pus secreted. 
The thought being suggested, that possibly the bichloride and not the peroxide was 
instrumental in producing the favorable results noticed, I commenced a series of 
control experiments. I would, at one dressing, use simply the bichloride of mercury, 
following this, at the next dressing, with the peroxide. Thus making actual 
comparisons in the same cases. After several alternate dressings as above, I found 
■without exception that the hydrogen peroxide perceptibly diminished pus formation to 
a much greater degree than simply the bichloride alone. 
1W. D. Bizett, Atlanta M. and S. Journal, 1888-9, N. S. 
Gifford, Med, Rec., N, Y. 1888, vol. XXXIV, p. 243. 
SI. N. Love, Phila. Med. Times, 1887-1888, vol. XVIII, pp. 362-364. 70 
The belief that iodoform should not be used in conjunction with the peroxide, for 
fear of liberating free iodine, which, as a direct irritant, would defeat the object in 
view, is, I believe, erroneous. I found that when a quantity of iodoform was placed 
in a small receptacle covered with the peroxide solution and then set aside for periods 
varying from three hours to three days, on being treated chemically for free iodine, 
with the ordinary starch test, gave negative results. Although one drop of a solution 
of iodine, on being added to the same solutions, gave a brilliant reaction on addition 
■of the starch. 
In all cases in which the peroxide was given a fair trial, I have observed a direct 
healing effect upon the granulating tissues. It is therefore evident that, owing to its 
oxidizing action on the pus and the diminution of the purulent secretions after its 
use, it does, either directly or indirectly, cause a destruction of the anthrax bacillus. 
In concluding my article. I think, from the chemical as well as the experimental 
evidence which has been deduced, we can safely sum up the action of peroxide of 
hydrogen in the treatment of surgical affections, as follows : 
I. Hydrogen peroxide is a positive germicide and a possible stimulant to 
granulating tissues. 
2. Owing to its especial property of eliminating oxygen, it is of unparalleled value 
in the distention of suppurating sinuses and cavities, especially in the mastoid region, 
or where it is almost impossible to reach unhealthy surfaces by other means. 
3. The diluted solution is perfectly harmless and can with safety be used in any 
■quantity. 
4. The strong concentrated solution, syrupy in consistence, is a direct irritant to 
all tissues and should never be used. 
5. It possesses healing and cleansing qualities as well as those germicidal in 
nature. 
6. When exposed to light it loses strength ; care should therefore be exercised in 
keeping the bottles well stoppered with rubber corks, and in a cool, dry place. 
7. Fibrin, cellular tissue and some metals, instantly decompose it. In contact 
with sugar and starch it eliminates carbon dioxide (CO2). 
8. In washing suppurating surfaces, it should be used until oxidation ceases, 
dhus showing a complete destruction of all existing purulent material.1 
EXTRACT FROM PAPER ON "ADJUVANTS OR AIDS TO 
GYNAECOLOGY-NEITHER MEDICAL NOR SURGICAL." 
By C. A. PHILLIPS, M.D., of Boston, Mass. 
Read before the International Congress of Homoeopathy, held at Atlantic City, 
June ig, 1891. 
. . . Another local application of great service in the treatment of gonorrhoeal 
or syphilitic and all ulcerative conditions of the genital organs is Marchand's Peroxide 
of Hydrogen. While its power to destroy germs and septic matter with which it 
comes in contact is unsurpassed by any other germicide or antiseptic, it is perfectly 
harmless to living tissues. With a swab of cotton saturated with this solution the 
parts can be more thoroughly cleansed than by any other means with which I am 
acquainted,-thus removing effete poisonous or septic matter, and I cannot understand 
wherein this is any more objectionable than cleansing the skin with soap and water, 
or the teeth with a brush. 
'Read before the D. Hayes Agnew Surgical Society of the undergraduates of the Medical Depart- 
ment of the University of Pa., February, 1891. 71 
MEDICINAL PEROXIDE OF HYDROGEN AND GLYCOZONE. 
By Df. J. H. De WOLF, of Baltimore, Md. 
{The Southern Medical and Surgical World, of Baltimore, Md., August, 1891.) 
The topical application of Oxygen is capable of immense benefit. In the pitting 
of Small-pox I most earnestly advocate and urge its use, either in the form of 
Glycozone or properly diluted Marchand's Peroxide of Hydrogen (Medicinal). I 
believe much deformity can be obviated by its use, and the force of the disease 
lessened. Foul and indolent ulcers, when treated by iodoform, carbolic acid, etc., 
are apt to poison the patients ; such cases have occurred. With oxygen that would 
be impossible. In large suppurating sores, where the various germicides are 
dangerous on account of the large breach of continuity and absorbtion of the poison, 
the topical application of oxygen is perfectly safe, and to say the least, equally 
efficacious. 
Opthalmia is advantageously treated by the topical application of either the 
Peroxide or Glycozone. Styes can be aborted if Glycozone be rubbed on the lids 
at the commencement; and as styes are painful, and swelling and pain last for a few 
days, the use of Glycozone is satisfactory to both patient and physician. In nasal 
catarrh, when the mucous membrane is dry and crusts form, prompt and more 
satisfactory results can be obtained from Glycozone than from any other means known. 
In the various chronic inflammations of the throat which are ordinarily obstinate 
to treatment, I have frequently satisfactorily treated by the Peroxide (diluted,) 
especially when the orifice of the eustachian tube was closed by swelling, and the 
patient rendered uncomfortable by temporary deafness and ringing in the ears. 
PEROXIDE OF HYDROGEN, MATERIA MEDICA AND THERAPEUTICS. 
Vol. II., Page 681, 1891. By JOHN V. SHOEMAKER, A.M., M.D. 
Professor of Materia Medica, in the Medico Chirurgical College, of Philadelphia, Pa. 
Pharmacology.-The usual strength of peroxide of hydrogen is called the fifteen- 
volume solution, because each portion of the solution yields fifteen volumes of the 
oxygen. It is prepared by Charles Marchand, New Yoik, for medical use, and is an 
active oxidizing and antiseptic agent. Glycozone is the trade name of a similar 
preparation in which glycerine is the vehicle. 
Therapy.-Though less powerful than many other antiseptics, the solution of 
hydrogen peroxide has a special place in surgery, gynecology, and obstetrics, on 
account of its power of decomposing pus and destroying the microbes of suppuration. 
Being free from all irritating qualities, it can be poured over wounds, injected into 
sinuses, or into the ear, or used as a spray in ulcerations of the pharynx and of the larynx. 
It produces a frothing up when it encounters pus, owing to the liberation of 
oxygen, and the cessation of this commotion indicates the removal of all pus. The 
surface of the wound or ulcer becomes blanched, but it is not injured by the application. 
Tubercular and mammary abscesses especially are well treated in this way. In 
ulcerative tonsilitis, fetid breath, and in some bronchial affections, a spray of dilute 
hydrogen peroxide is productive of benefit. A spray of this agent is likewise of utility 
in chronic nasal catarrh, ozcena, and scarlatinal angina. It has been administered, 
well diluted, in gastric affections, and is said to be very useful in flatulent dyspepsia, 
heartburn, catarrh of the stomach and bowels, etc. 
In diphtheria and croup its value has been established ; a two volume solution is 
specially recommended in young children as a local application, and particularly after 
separation of the membranes, in order to remove the odor and disinfect the surface. 
Internally it is too quickly decomposed in the stomach to render much service as a 
source of oxygen to the blood. It might prove of value in gastric ulcer. 72 
PEROXIDE OF HYDROGEN IN DISEASES OF THE 
MUCOUS AND SEROUS MEMBRANES. 
[.A paper read before the International Homoeopathic Congress, Atlantic City, N. J. June 16-23, 1891.] 
Published by the "Medical Era" of Chicago, November, 1891. 
W. S. MULEINS, M. D., Henderson. Kv. 
Since the discovery of Peroxide of Hydrogen in 1818 by the French 
•chemist, Thenard, and its introduction to the medical profession by Richardson, in 
1858, it has, like most remedial agencies brought forth by the empirical school of 
medicine, enjoyed great favor for a few years, only to fall into disuse, not because 
it did not possess virtues peculiar to itself, but from the fact that it was an impure 
chemical substance, producing escharotic effects when applied locally, and 
poisonous effects upon the system when diluted. 
What it may do outside of its remedial effects upon mucous and serous 
membranes, I know not. But the results obtained in diseases of the nose, throat, 
■ear, skin and womb, I have had an extended clinical experience often years. It is 
Al archand's Peroxide of Hydrogen, H2 Og, that I speak. 
I know of no chemico-therapeutical substance of modern use, that brings the 
physician a more decided and powerful curative action, in its range of indications. 
Before entering into its clinical adaptation, permit me to say, by way of caution, 
that in no instance, and under no circumstances, should the commercial and 
poisonous peroxide of hydrogen be used. Neither should it be applied or inhaled 
except by means of glass, rubber, porcelain or gold instruments, as its effects are 
certainly contaminated, if not entirely destroyed, by any other appliances than the 
ones named. 
In acute, subacute or chronic cases of catarrh of the head, when accompanied 
by an acrid, excoriating discharge, and much sneezing, it will almost certainly 
control the sneezing and change the nature of the discharge from acrid to bland. 
In chronic nasal discharge, either from the anterior or posterior nares, of a 
yellowish greenish fetid character, with an accumulation of hardened pus and 
scabs in the nose, it will soften them and cleanse the nose effectually. 
In both conditions of nasal catarrh as enumerated to be followed by an 
application of glycozone on a cotton swab; or, better still, to saturate a small 
cotton tampon of borated cotton with the glycozone and place it well up each 
nostril; allow it to remain from one to two hours, cautioning your patient to 
remove it gently and to desist from any forcible blowing of the nose between 
treatments. 
In granular pharyngits, produced by smoking, apply by means of a spray as 
follows: 
Peroxide of hydrogen, 15 volumes, e ss. 
Aqua distillata, § ijss. 
To be followed by inhalations of ozonized vapor. It is a radical cure. Three 
-sprayings and three inhalations in bad cases, and once a day in simple cases, should 
be used, cautioning your patient to hawk as little as possible. 
In diphtheria, an early application of copious and frequent spraying of the nose, 
mouth, throat, pharynx, and larynx, administered with a mixture of: 
Peroxide of hydrogen, 15 volumes, - ss. 
Aqua distillata, ? iij- 
When diphtheria is well developed, irrigate copiously and frequently, the 
nostrils, pharynx: mouth and larynx, with a stronger mixture as follows: 
Peroxide of hydrogen, 15 volumes, 5 jss. 
Aqua distillata, 3 ss. 
The above is the best local application for this most dread disease. It is to 
be used of course with the indicated internal remedies. 73 
In bronchitis and asthma, administer ozonized vapor inhalations three or four times a 
day with a mixture made as follows; 
Peroxide of hydrogen, 15 volumes, 3 jss. 
Glycerine, § j. 
Koch's lymph or Shurley-Gibbes iodine, chloride of gold and sodium, are 
nowhere in benefiting your consumptive patients, when compared with the 
following: 
Peroxide of hydrogen, 15 volumes, 3 ij. 
Pure glycerine, § j. 
M. Sig. Shake well, inhale for ten minutes, three times per day, in alternation 
with the following: 
Fl. ext. Hydrastis, 3 ss. 
Glycerine, 3 j. 
Kreasotum, M. vj. 
Aqua distillata, 3 jss. 
M. Sig.: As directed. 
In cases of the many different varieties of eruption seen so often upon the faces 
of young girls from 15 to 23 years of age, including blackheads, by applying first 
for .about three minutes, to the face a flannel cloth as hot as can be, wrung out of 
hot water, then apply by means of a sponge, Marchand's full strength Peroxide of 
Hydrogen, followed by rubbing well into the skin, boracic acid; one to three 
applications per day, according to the severity of the case, will give you all the 
reputation you desire as a dermatologist. 
CONJUNCTIVITIS The following makes a splendid application for 
catarrhal or granulated conjunctivitis: 
Glycerine. 3 j. 
Boracic acid, 3 j. 
Mix well in a mortar and add Peroxide of Hydrogen, 3 j. Apply by means of 
a camel's hair brush. Keep well corked. 
CHRONIC ULCER.-I have just dismissed, from my office, cured, an old 
chronic ulcer of the leg of fifteen years' duration. It was one inch deep, three 
inches long and two inches wide. 
The only treatment the patient received was the application of peroxide of 
hydrogen, 15 volumes, dropped on carefully night and morning by an ordinary 
glass dropper, being careful not to disturb the white foam thereon, The whole 
was then covered by borated cotton, saturated with glycozone, oil silk over this, 
the leg kept bandaged from the foot to the knee by an Empire elastic bandage-by 
the way, far superior to Martin's. 
During the three months he was under my treatment, he received three doses of 
sulphur, 47m, ten doses of Arsenicum 3X, ten doses of Argentum nit. 6X, ten doses 
of Lachesis 6X, ten doses Calcarea sulph. 6X, which, in my mind, contributed much 
in curing the case. 
GYNECOLOGY.-In the field of gynecological work, nothing serves me as 
well and often, nor is there anything, in my opinion, to take its place. 
ABSCESS OF THE LABIA.-Puncture with bistoury, cleanse with pure 
Peroxide of Hydrogen, 15 volumes, then by hypodermic syringe inject slowly into 
the sac, 10 or 15 drops of Glycozone; very little reaction follows, and the 
results are perfect. 
VAGINITIS.-As a vaginal douche, use hot buttermilk; then by aid of the 
speculum and a small cotton swab, on an applicator, applying the pure Peroxide of 
Hydrogen, 15 volumes, to the entire mucous membrane, including the cervical 
canal, to be followed at once by an application of Glycozone. Insert into the 
vagina a roll of cotton saturated with Gleyozone, which serves to keep the 
inflamed surfaces apart. Use the same treatment for vulvitis. 74 
ENDOMETRITIS.-In endometritis, when the discharge is white and acrid, or 
yellowish, greenish and fetid, apply full strength, 15 volumes, being careful not to 
wipe off the foam generated; follow by one application of a tampon, or tampons, satu- 
rated with Glycozone. 
CHRONIC METRITIS.-Copious hot water vaginal douches; then apply 
full strength, Peroxide of Hydrogen, 15 volumes, followed by tampons of Glycozone, 
applied every other day. This treatment is worth the consideration of any member of 
this institute. It is, of course, understood that in all cases the indicated remedy must 
be used, combined, in the judgment of the physician. 
In almost all cases where the Peroxide of Hydrogen is used in the nose or throat, it 
should be diluted one-third, one-fourth, one-half, three-fourths, and sometimes four- 
fifths, with pure distilled water. 
My rule has been, except in cases of nasal catarrh, accompanied with much 
sneezing and very acrid excoriating discharge, to use it just strong enough to produce 
a very slight,tinkling sensation. 
It should be borne in mind that, when used in the nasal cavities, it produces fre- 
quent sneezing, and if too excessive should be diluted still more. If its use on irritated, 
inflamed or ulcerated surfaces should produce a too free discharge of blood, you may 
conclude that it needs further weakening. 
If you desire a better, quicker and more effective local treatment for carbuncles than 
carbolic acid, in conjunction with your constitutional remedies; inject pure medicinal 
Peroxide of Hydrogen by use of hypodermic syringe; a keen, cutting, stinging pain 
follows. When the pain has subsided, inject by same means, a few drops of Glycozone. 
I am only sorry my time will not permit me to enter as fully as I would like in explana- 
tion of its beneficial use, and speak of its great curative powers in eczematous vesicular 
eruption, in vesicular erysipelas, in aphthous and cancerous conditions of the mouth and 
of its value as an internal remedy in gaseous dyspepsia that will not respond to Lycopo- 
dium, China, Argentum, Magnesium, Phosphorus or Carbo veg. 
As I have already indicated, I have great faith in the Peroxide of Hydrogen, in the 
treatment of consumption. Give inhalations on alternate days, of the Peroxide, and 
Hydrastis, at the same time giving nourishing food, and attending to other conditions. 
It has helped me to cure several well-developed cases of consumption. The use of the 
Hydrastis is not original with me, but the plan of alternating the two I have never 
known to be used by others. 
I am loth to leave this, to me, interesting subject. I trust that it may be of benefit 
to you. 
WAX IN THE EARS. 
By A. S. TUCKLER, '92, C. M. C,, S. F. 
(Published by the California Medical Journal., San Francisco, Cal., June, 1892,) 
A simple method of removing "wax in the ears," is to take peroxide of hydrogen, 
(Marchand's) warm it in a water bath, then with an atomizer spray the meatus for about 
five minutes. This will soften and partially dissolve the cerumem. An ear spoon will 
now remove the mass and to the surprise of the patient, the sense of hearing will be im- 
mediately restored. A little more of the spray to cleanse the parts will be all that is 
necessary. This is a far safer method than the digging out process and not liable to 
perforate tympanum, an experience which the writer has been subjected to. 75 
SOME PRACTICAL POINTS IN THERAPEUTICS. 
Professor of the Principles and Practice of Medicine, Hospital College of Medicine, 
Louisville, Kentucky. 
JOHN A. LARRABEE, M. D. 
(Abstract of paper read before the Louisville Medico-Chirurgical Society, Oct. 2, 1891). 
Permit me, in conclusion, to make mention of those therapeutics agents which, dur- 
ing the summer months, have been weighed in my practice and have not been found 
wanting. In entero-colitic diarrhoea, the so-called "summer complaint" of cities, de- 
pendent upon the various micro-organisms, vitiated air, and bad food, salol, napthaline, 
carbolic acid, (nascent), calomel in minute doses and nitrate of silver, have stood the 
test. In gastro-enteritis, I have found salicylate of bismuth useful, and in inflammatory 
diarrhoeas (the dysentery of some authors) of infants and older children, Rochelle or Epsom 
salts in acid infusion of roses with small doses of laudanum. In chronic cases the nitrous 
acid camphor mixture of Dr. Hope has not failed. For the gastric fevers so common in 
children, the preparations ammonia-phenique and sulpho-phenique of M. Declat have 
been used exclusively in a large number of cases with much better results than any former 
treatment; also the same for the exanthematse. For "whooping cough," Declat's syrup 
coqueluche is nearly a specific. In diphtheria, locally, Marchand's peroxide of hydrogen 
and whiskey internally have established their value. A word in regard to the use of the 
peroxide. It should always be purchased in the smaller four ounce bottles, protected 
from the light by blue glass bottles and corked with rubber. That sold by the druggists 
from large bottles is, in the majority of cases worthless. It is a very unstable article, and 
unless it causes immediately a white, foamy reaction when brought into contact with the 
false membrane, it should be discarded and another lot obtained. I am satisfied that 
I use it more freely and more persistently than most practitioners. I use mops made 
by twisting a sort of absorbent cotton upon sticks, using as many as thirty or forty in 
the twenty-four hours. Such mops will take up nearly a half ounce apiece, and when 
forced well back into the pharynx, reach all parts. The gagging and resistance of the 
child assists in the distribution of the fluid. As soon as a mop has been used it is com- 
mitted to the fire. In this way I have treated the worst as well as the milder forms of 
diphtheria with complete success. I believe that the systematic use of definite, although 
often toxical doses of whiskey, even in children of tender age, to be the surest safeguard 
against heart failure. 
PEROXIDE OF HYDROGEN IN TYPHOID FEVER. 
H. F. WIGGIN, M. D., 55 w. 36TH st., new york. 
(Published by the New York Medical Record, November 28th, 1891.) 
Having had good results in using Peroxide of Hydrogen locally in diphtheria 
and tonsillitis, and in infected wounds, it occurred to me, when a case of typhoid fever 
came under my care, during my summer practice, that this remedy might be beneficial, it 
being the most powerful non-poisonous germicide we possess. 
On August 24th I was called to see Abby M. , who gave a history of having been 
ill for a week with fever and diarrhoea. On examination I found a characteristic case of 
typhoid fever with temperature 1044-° F.; pulse, 130; sore spots, abdominal pain, tym- 
panites, diarrhoea, and mild delirium. I prescribed one ounce of fifteen volume peroxide 
of hydrogen* to eight ounces of water, to be taken every three hours, by the mouth. 
♦Since the above report has been published by the New York Medical Record, Dr. H. F. Wiggin 
stated April 14th, 1892, that Marchand's Peroxide of Hydrogen (medicinal) was used by him in this 
case. 76 
On the following day I found the patient more comfortable; temperature, IO3°F.; pulse 
112; had had only two movements during the twenty-four hours; less delirium and less 
pain in head. On the 26th had had one movement; temperature IO2°F.; pulse, 104; 
less tenderness in abdomen, and pain in the head diminishing. On the 27th, tempera- 
ture, ioo|° F.; pulse, 98; no movement; tympanites disappeared, and head, though still 
weak, clearer. On the 29th, temperature, 99!° F.; no movement. On the 30th, tem- 
perature normal; pulse 84; formed movement. The case now went on uninterruptedly 
to recovery, with nothing further of interest to report. On the 9th of September I dis- 
continued my visits, the patient being discharged, cured, though weak. 
One swallow does not make a summer, but I report this case hoping that some one 
who has larger opportunities for treating typhoid fever may take up the suggestion and 
let the result be known. The remedy is perfectly harmless, easy to take, and apparently 
was of very great value in this case. 
SUBSTITUTION AND ITS ATTENDANT EVILS. 
JOHN AULDE, M. D., of Philadelphia, Pa. 
(Published by The Journal of the American Medical Association, Chicago, Ill., Decem- 
ber 5th, 1891.) 
The evils attendant upon substitution and sophistication of remedial agents have long 
been surmised; they have not, however, until recently, received attention at the hands of 
the medical profession. Increased diagnostic skill, along with greatly improved 
facilities for the manufacture of medicaments, favor an approach toward mathematical 
exactness in computing therapeutics results. When these are wanting we challange the 
character of the remedy. The question which presents itself is: Has our patient re- 
ceived the true medicament or abase counterfeit? However attractive in theory, it will be 
found impractical for the medical profession to drift away from the pharmacists and it 
should be our aim to reward the faithful and bring the guilty to punishment. The 
friendly bond between the two professions should be honesty, as neither can afford to 
work independently: there is an interdependence which makes them mutually helpful. 
It is said of Lawson Tait, that he has returned to first principles and carries a mill 
with him, so that when ergot is needed, he prepares it fresh with his own hand. The 
reliable character of Squibb's ether has been maintained through his business sagacity in 
having it prepared chemically pure and distributed all over the world in sealed cans, thus 
precluding the possibility of sophistication or substitution. 
The life of a patient suffering from rheumatism may depend upon his being supplied 
with sodium salicylate prepared by a combination of Merck's chemically pure bicarbonate 
of soda and true salicylic acid obtained from oil of wintergreen, and yet few pharmacists, 
even in large cities, pretend to keep either in stock. They are the exception in Phila- 
delphia, and doubtless the same is true of other cities. 
Some years ago Dr. Squibb, of Brooklyn, set his seal on Marchand's peroxide of 
hydrogen, by endorsing its character and defending its merits as the most powerful and 
yet harmless bactericide which could be employed in the treatment of various formidable 
and fatal diseases. Dr. Robert T. Morris, Dr. Paul Gibier, and other well-known 
authorities have corroborated his statements from clinical observation, and as a conse- 
quence, a revolution has taken place in our methods of treatment in both medical and 
surgical practice. The efficacy of this simple remedy, its innocuousness and extended 
field of application, have shed a flood of light upon modern therapeutics, but at the same 
time there has followed in its train a host of worthless imitations. 
The substitution of the commercial for the medicinal peroxide is calculated to work 
serious injury and destroy our confidence in a most potent remedy. In the treatment of 77 
diphtheria, for instance, the commercial product is positively harmful. When deaths re- 
sults, shall we blame the attending physician or the unscrupulous druggist who substi- 
tutes a base imitation for the genuine product? And still, pharmacists who claim to be 
respectable, do not hesitate to trifle thus with human life. Is it any wonder then, that 
our mortality percentages are on the wrong side? 
Cascara sagrada has been counterfeited and sophisticated until it is almost impossi- 
ble to secure a reliable preparation of this most useful medicament, although Parke, 
Davis & Co., the pioneers in its introduction, have adopted every means in their power for 
the protection of the medical profession. Antipyrin, a patented preparation, has met 
with phenomenal sales, and possesses distinct therapeutic properties, and as a result, 
imitations and substitutes are offered to take its place in medical practice. Whether these 
imitations are better or worse than the original product, I do not care to discuss; neither 
is it for the druggist to decide. The decision here, as to any special remedy or prepara- 
tion, rests entirely with the physician, as he alone is responsible for the condition of his 
patient; no one else, not even the druggist, should be permitted to interfere with his 
directions. Substitution is an evil which should be guarded against; it is an evil which 
must be eradicated, or the entire medical structure will collapse. It is a duty we owe to 
ourselves and to our patients to look after this unnatural condition of affairs in which we 
are so vitally interested, and the time is near at hand when a systematic effort must be 
made with a view to accomplish the desired end. 
This subject is commended to the attention of the American Medical Association, 
with the suggestion that a committee be appointed who shall recommend suitable meas- 
ures for the protection of the medical profession from the evils of substitution and so- 
phistication on the part of unscrupulous pharmacists. Shall we have a list? 
4719 Frankford Avenue. 
HYDROGEN PEROXIDE IN PELVIC ABSCESS. 
(Published by the Bacteriological World of Battle Creek, Mich., December, 1891.) 
We have for a number of years made the use of peroxide of hydrogen (Marchand's) 
in the treatment of suppurating surfaces, abscesses, etc., with excellent results, but have 
never observed a more gratifying result than that recently obtained in a case of pelvic 
abscess of long standing. The abscess discharged by a small opening just behind the 
cervix uteri, and was very profuse, and extraordinarily foetid. Our stock of peroxide of 
hydrogen happened to be exhausted at the time, the new supply ordered being somewhat 
delayed in reaching us, and we at first employed listerine, using it in the proportion of 
one part to three of distilled water. There was no apparent effect upon the discharge, as 
regards either quantity or character. The odor continued as bad as ever. When the new 
supply of peroxide of hydrogen arrived, we immediately began using it in the proportion 
of one part to ten of distilled water, with the result that after the first washing the in- 
tensely foetid odor disappeared entirely, the discharge became healthy in appearance, and 
diminished in quantity so rapidly that within ten days there was no discharge whatever, 
except at the washing, and then the quantity evacuated was not more than a dram, when 
it had previously been several ounces, besides continuous discharge in the intervals be- 
tween the washings. 
After the first washing with peroxide of hydrogen, the patient's temperature, which 
had for several months previously been above normal, fell to normal and has remained at 
that point since. There is certainly at present no agent known which could properly re- 
place hydrogen peroxide as a disinfectant of unhealthy surfaces. 
It would seem to be especially valuable in the treatment of abscesses, the discharges 
of which, through the relation of the cavity and the lower part of the alimentary canal, 
usually possess so repulsive an odor as to render the existence of the patient almost un- 
endurable. J. H. K. 78 
DENTAL MEDICINE. 
Abstract of paper read before the New England Dental Society, October 29th, 1891. 
By R. M. CHASE, I). D. S., M. D., Bethel, Vt. 
(Published by the International Dental Journal, Philadelphia, January, 1892.) 
Peroxide of hydrogen still stands at the head as a germicide, and undoubtedly is one 
of the best antiseptics yet discovered to annihilate germs, bacteria, or microbes. Charles 
Marchand's preparation, Hs O2, is, I believe, the best article in the market, as peroxide 
of hydrogen is very susceptible to certain conditions. To get the best results it should be 
kept in a cool place, well stoppered and when required for use as much as desired should 
be poured from a large bottle into a small receptable, and only what is to be used should 
be exposed to the light. When small cavities are to be cleansed it should be injected with 
a small glass or rubber syringe, as metal should not be brought into contact with it as it 
quickly destroys its utility. For reaching pulp canals I find a small glass medicine drop- 
per very convenient as by pressing upon the rubber bulb quickly it is forcibly ejected 
and is thus forced into the pulp canal without much trouble. I use a wooden tooth pick 
reduced in size to still further push it into the root. In treating all ill-conditions of the 
oral cavity I make it a rule to first rinse thoroughly the mouth with peroxide diluted, and 
then apply remedies suitable for the same. Much more could be said and undoubtedly 
will be brought out in this discussion upon this and other valuable antiseptics. 
PEROXIDE OF HYDROGEN IN THE TREATMENT OF 
DIPHTHERIA. 
(Published by the North Western Medical Journal, Minneapolis, Minn., February, 1892.) 
In the next chapter, we shall give further details with regard to the treatment of 
diphtheria, but at this point we feel that we should not close without announcing in the 
most emphatic terms, that one of the most available agents that we have for the fighting 
of diphtheria locally, and preventing constitutional involvement, is the "Necessary Peroxide 
of Hydrogen" made by Chas. Marchand, of New York. We would take no chances by 
using any other manufacture. Charles Marchand was the pioneer in the development of 
this particular agent, for medical use. It is the "Medicinal" Peroxide of Hydrogen which 
can be depended upon to render diphtheria germs inert as thoroughly as water can be de- 
pended upon to put out a fire, or as heat can be relied upon to annihilate the icicle. We 
believe that every case of sore throat, whether pronounced diphtheria or not, as well as 
every case of scarlet fever, should have applied to the throat at intervals varying accord- 
ing to the necessities of the situation, the full strength of the Marchand's Peroxide of 
Hydrogen. It may be used as a gargle, though I am somewhat in favor of flushing the 
parts with a good syringe, or if this is not available, owing to the objection of the patient, 
particularly if it be a little one, atomizers are now furnished which act very efficiently, 
and by using them frequently, the full effects can be secured. It is well to give internally 
occasionally, teaspoonful doses of the peroxide. It may be diluted or not, as one pleases. 
All the secretion which has been swallowed will thus be acted upon in the stomach. In ad- 
dition, there is a general accumulation of fermentative products in the stomach, undi- 
gested food, etc. The oxidation of these irritants is desirable. If the patient complains 
that the application is irritating, it may be diluted with one, two or three parts of water. 
The position which we took nearly four yearsago with reference to the use of Perox- 
ide of Hydrogen in the treatment of diphtheria in a paper read before the St. Louis Medi- 
cal Society, has been strengthened with the experience which has followed. We would 
emphasize every material point then made in that paper. If asked "if we were to depend 
upon only one agent in the local treatment of diphtheria, what would we call for, " the re- 
sponse would be emphatic, in thundering tones, "Marchand's Peroxide of Hydrogen," and 79 
if we ascertain that any druggist furnished our patient with any other than Marchand's 
it would be sufficient for us to condemn that druggist and rather than run the gauntlet of 
his repeating the offence, we would supply the medicament at our own expense. 
RECENT INVESTIGATIONS RELATING TO THE PRE- 
VENTION OF DIPHTHERIA AND SCARLET FEVER. 
Professor Diseases of Children, Bellevue Medical College, New York. 
Abstract of paper read before the New York County Medical Association, March 21st, 1892. 
DR. J. LEWIS SMITH, 
In his report the author entered fully into the pathology and etiology of the two 
diseases, and dwelt at some length on their differential diagnosis. He related many 
interesting facts in connection with the contagiousness of diphtheria, spoke of a case of 
the disease resulting from the employment of a brush that had been used for swabbing 
the throat four years before in a similar trouble. Does not believe diphtheria ever orig- 
inates de novo, that it is dependent at all times on the presence of a specific microbe. 
Damp cellars, the presence of sewer gas and other unsanitary conditions contribute 
largely to its development. Many mild attacks of the disease are overlooked by the 
attending physician, and as a consequence it is communicated to others, notably in the 
school room. He believes in thorough disinfection as a means of preventing a spread of 
the disease. Does not have much faith in sulphur for this purpose; prefers a strong 
solution of corrosive sublimate or five per cent, solution of carbolic acid. This should 
be used freely on walls and floors of rooms where the disease prevails. With the same 
solution the bedstead and other articles of furniture should be thoroughly washed. 
In examining patients suspected of having diphtheria or scarlet fever, the phy- 
sician should place himself on one side or in rear and not in front, as is usually the prac- 
tice. In this manner he avoids the dangers of any diseased matter that might be coughed 
up by the patient. After such examinations the physician should thoroughly bathe his 
hands and face in a solution of corrosive sublimate. Exclude everybody but the physician 
and nurse from the room where a case of either disease exists. While small-pox is thor- 
oughly under control in this city, he doesn't think it possible to gain such control over 
the two diseases under discussion. The crowded condition of our large tenement houses 
supplies so much material for their ravages that it is impossible to stamp them out. For 
the purpose of illustration, the reader related the following experience: 
He was called to see the child of a poor woman, living in a tenement house in which 
there were twenty-seven families. He found a child two years old very sick with diph- 
theria. Five other children lived in the same rooms; of these, two were away at the 
time of his visit, at school. Just think of the hundreds of children thus exposed! The sick 
child died two days later. 
For purposes of fumigation the author recommended the following: 
R Ol. Eucalyptus, 
Acid carbolic,aa § j. 
Spts. Turpentine, | viij. 
M. Add two tablespoonfuls of this mixture to a pint of water and evaporate by aid of a 
lamp; or cloths saturated with the mixture may be hung around the room. 
Does not believe in the efficacy of sulphur fumigation. Microbes in a state of activity 
may be found in the sweepings obtained from a room that has been fumigated with sulphur. 
For the local treatment of diphtheria and scarlet fever, he recommends the following 
E 01. Eucalyptus, 
Acid Carbolic, aa 3 j. 
Ol. Olive, 3 vij. 
M. Sig. Apply every three hours. 
He also uses Marchand's medicinal Peroxide of Hydrogen one part, to three parts of 
(Published by the Doctor's Weekly, March 26th, 1892.) 80 
water, with much satisfaction. It is prompt in action and quickly destroys the diph- 
theritic membrane. 
Dr. Smith's paper was discussed by Drs. Leale, Tyndale and Koplik. 
SOME NOTES ON THE VALUE OF PEROXIDE OF 
HYDROGEN 
Editor of Practice, Richmond, Va.: 
Having read in the January'number of your excellent journal, the experience of Dr. 
S. Potts Eagleton in the use of "Hydrogen Peroxide in Surgical Affections," I am 
prompted to send you for publication the following: 
In January I was called to see a lady in her seventy-sixth year of age, suffering, as her 
husband supposed, from an inguinal hernia, but upon careful examination, I diagnosed 
a deep-seated abscess, and at once ordered hot poultices, to be made of equal parts of 
flax-seed and corn meal, and applied in the following manner over the skin: White gauze, 
hot poultice, muslin, oil silk, After a few poultices had been used it was in a condition 
to be opened. A good incision, giving free drainage was made. The cavity was eight 
inches in depth. Every day the cavity is syringed with "Peroxide of Hydrogen" (Mar- 
chand's,) full strength. 
The first effect noticed was the rapid oxidation of all purulent matter, which caused 
the distention of the cavity with the gas eliminated as a frothy yellowish (or yellowish- 
green) bubbling substance. After the oxidation is completed the wound is always in a 
clean, sweet condition, absolutely free from pus. The cavity is dusted with iodoform, 
and antiseptic dressings applied. The cavity is gradually healing up from the bottom. 
In my experience "Peroxide of Hydrogen" (Marchand's) perceptibly diminishes the pus 
formation. In this connection, I will also state that I am using "Peroxide of Hydro- 
gen" in a case upon which I operated February 16th, and from which was removed 
a large multilocular ovarian tumor and also an enlarged uterus with many fibroids 
(hysterectomy). The wound (stump) is in a healthy condition; her general condition 
is good. Indeed, she is getting along finely. The clamp-came away yesterday. The 
sixteenth day was up yesterday, counting by hours, from the time of the operation. 
The wound is in a healthy state, and perfectly healed. Hardly a day passes that I am not 
using the "Peroxide of Hydrogen" in my practice. I send you these notes, hoping they 
will assist some brother practitioner who may be a reader of your practical journal. 
Doctors talk with each other about their cases, and I believe they are as much interested 
in exchanging their experiences by correspondence. We are all mutually concerned. 
Very truly yours, Robert T. Wilson, M. D., 
(Assistant Surgeon to the Hospital for the Women of Maryland.) 
Baltimore, Md., March 4, 1892. 
DIPHTHERIA, LOCAL TREATMENT. 
By I. N. LOVE, M. D., St. Louis, Mo. 
(Published by the Medical Mirror, of St. Louis, March, 1892.) 
Judgment should be exercised in this as in everything else. If we select the applica- 
tions properly they will be sufficiently agreeable as not to annoy or irritate more than 
they benefit. It may be necessary to avail an opportunity for the application; for the 
patient may be fretful, easily demoralized by being disturbed; we should wait until rest 
has been secured, until the sensibilities have been obtundedby proper internal medication. 
We should bring to bear our ingenuity to the fullest and diplomacy also; if possible ascer- 
tain if the child has a fondness for any particular thing. We should arrange a plan by 
which a reward in prospect may assist in accomplishing our desires. 81 
For its germicidal effect, and also for the removal of the mechanical obstruction 
produced by the diphtheritic membrane, Marchand's Peroxide of Hydrogen, (medicinal) 
should be used promptly, in its full strength, but later it may be diluted to one-half 
strength. As the mucous membrane becomes exposed after the removal of the deposit, 
by the means just mentioned, it is important to have on hand an application which is 
soothing, astringent and at the same time as much antiseptic as it can be made. 
I have found the following valuable for this purpose: 
R Katharmon., § ij. 
Glycerine, 3 j, 
Aquae Cinnamonis, § iij. Sig. 
The Peroxide of Hydrogen may be labeled No. I, the formula just written No. 
2. The best means of applying both applications is either by a glass syringe, or an 
atomizer made of hard rubber; but in case neither of these appliances are at hand or 
available, a piece of wire (silver or platinum) of good strength, may be bent, with a hook 
at the end, in such a manner, as to serve as a probang by wrapping a pledget of absorbent 
cotton at the point; the application may be made after thoroughly wetting the same 
with the solution. No. 2 application should follow No. 1, and will be gratefully received 
by the little patient. 
WOUND CLOSURE AFTER THE EMPYEMA OPERATION 
By CHARLES W. AITKIN, M. D., Flemingsburg, Ky. 
(Published by the Ohio Medical Journal, of Cincinnati, April, 1892., 
Several times the writer has found it difficult to close the wound made in an operation 
for empyema, especially if the empyema was of any magnitude or of long standing, so 
that the lung's function was destroyed by compression, and bound down by adhesions. 
Mrs.V.,aet. 32, of Bath County,Ky., was confined April 20, 1891. The physician in 
attendance, Dr. Judy, informs me that there was nothing abnormal in the labor. On 
April 30th the patient had a chill, and for several days the temperature ranged from 1030 
to IO4°.5. After a few days more she began to complain of pain in left chest and 
shoulder. I saw her May 24th, in consultation with Drs. Judy and Sharpe, and we agreed 
to aspirate the left chest; over four pints of fluid were removed; two and one-half pints 
were fair serum, but the last one and one-half pints had some purulent appearance. 
During the next six weeks the patient was aspirated several times, and over ten pints of 
sero purulent fluid was removed at these various tappings. At this time a thoracotomy 
was decided upon. The patient was taken to the Good Samaritan Hospital, and with the 
aid of Dr. French, with the house physicians, Drs. Buel and Schoolfield, I opened the 
chest and let out over four pints of pus, the cavity was thoroughly washed with a sat- 
urated boracic solution, and the usual drainage and dressing applied, the case was left in 
Dr. French's care. The flow of pus was considerable for a week, after that time the 
boracic irrigation was followed by washing the cavity every day with Peroxide of 
Hydrogen. The quantity or pus rapidly diminished, the patient gained in strength and 
weight, and in about four weeks more came back to her Kentucky home. Her husband 
continued washing the cavity with both the boric solution and H 2 O 2 until September 
12th, when I again looked after the case for a week, preparatory to closing the wound, 
but as there was still an ounce or so of pus passing per diem, it was thought advisable to 
continue the Peroxide a while longer. This was kept up a month, when the quantity 
discharged was not more than one-half ounce a day, but to shut off this drainage for 
twenty-four hours wiuld cause an elevated temperature and general septic symptoms; 
at this time a I to 4000 bichloride solution was substituted for the boracic solution, the 
H 2 O 2 being continued, a slight bloody discharge was thrown out for a few days, but 
lessened gradually, until November 3, when I washed the cavity with a 1 to 5000 bichloride 
solution, followed with the Peroxide of Hydrogen for a few days, and let the wound 
heal without any unpleasant symptoms. The chest was measured during February, 82 
1892, and at auxiliary, mammary and ensiform levels, the left semi-circumferencc was one 
inch less than the right. The Peroxide of Hydrogen certainly aided very materially in 
arresting the suppurative process. Marchand's pure Peroxide of Hydrogen was used 
with but little dilution. 
AN INTERESTING CASE OF EMPYEMA WITH SPECIAL 
REFERENCE TO THE USE OF PEROXIDE OF 
HYDROGEN. 
By H. F. BROWNLEE, M. D., of Danbury, Conn. 
This case is interesting in many ways; namely: the length of time which elapsed previ- 
ous to diagnosis, the degree of exhaustion present at that time, the amount of pus evacu- 
ated, and finally, the perfect and rapid recovery of the patient. 
Previous to his sickness, this patient was a strong healthy man of about 30 years of 
age, but who for a few years past had indulged in rather frequent dissipation. 
About Dec. 20th he was suddenly taken very sick. The attending physician diagnosed 
pneumonia and began a vigorous course of treatment which he continued for four weeks. 
The pneumonia did not resolve but the attending physician continued diligently in his 
efforts to bring about resolution and at the time I saw him first, over four weeks after 
the beginning of the attack he was supplied with four glasses of medicine with instructions 
to take a teaspoonful of each every hour. Upon examination I diagnosed empyema and 
demonstrated it by the introduction of a hypodermic needle. 
At this time the patient was in a condition of extreme exhaustion; temp. 105. pulse 
hardly perceptible, respiration 48. I had him removed at once to the Danbury hospital; a 
small amount of ether was administered and a resection performed, removing about an 
inch of the sixth rib in the axillary line. An opening was then made into the pleural cav- 
ity and two gallons of pus evacuated. I did not know the maximum amount of pus 
ever evacuated in a case of this kind, but I can hardly conceive of a greater amount be- 
ing contained in the pleural cavity of an ordinary man. The cavity was washed out with 
Thiersch's Sol. and two large drainage tubes placed in the wound. The patient became 
quite cyanotic during the operation and required very active stimulation for several hours 
afterward. 
So much for the case itself, now a few words in regard to his treatment and course of 
recovery. For two weeks the pleural cavity was washed out every day with Thiersch's 
Sol. The patient slowly improved but his temperature continued to rise every evening 
to 102 or 103. I then substituted a Sol. of Hydrarg. Bichloride 1-5000. This was used about 
a week when a very active salivation presented itself. During this time the temperature 
did not run so high but still continued at about 101 to toif in the evening. I then began 
washing out the cavity with Peroxide of Hydrogen and if I had done this before I would 
certainly have gained considerable time. I used Marchand's preparation, full strength, 
putting in a considerable quantity of it with a small syringe, then allowing it to escape 
and finally washing it all out with a weak Borated Solution. 
From this time my patient began rapidly to improve. The temperature fell to almost 
nothing, rarely exceeding 99! at night. In two weeks from this time the discharge had 
entirely stopped and I was able to remove my drainage tubes, the wound closing in a few 
days. He gained rapidly in strength and in eight weeks from the day of operation he was 
able to return to work. 
I can not say too much in praise of Marchand's Peroxide of Hydrogen (Medicinal) 
in the treatment of this case. It kept the pleural cavity so clean that there was hardly 
any septic absorption and finally prevented all formation of pus, the discharge ceasing 
entirely in two weeks from the time I began its use. 
(Published by New England Medical Monthly, June, 1892.) 83 
THE VALUE OF PEROXIDE OF HYDROGEN IN THE 
TREATMENT OF CHRONIC GONORRHCEA, 
ILLUSTRATED BY A CASE. 
By WILLIAMS ROBERTS, Hospital Steward, U. S. Army, Plattsburgh 
Barracks, N. Y. 
(Published by The Journal of the American Medical Association of Chicago, 111., April 30, 1892.) 
During the past few years, the many articles on new drugs in the treatment of gon- 
orrhoea leave nothing to be desired in this way. The present aritcle contains nothing 
new, but simply gives the history of a case of chronic gonorrhoea arrested by the use of 
Peroxide of Hydrogen-a drug that is "going the rounds," probably to be discarded by 
reason of its being so unhandy and so little understood. 
The following case might serve to illustrate the value of Peroxide of Hydrogen, when 
used under conditions favorable to the preservation of the drug. 
J. H., citizen, age 23, contracted a gonorrhoea March 20, 1890, and received the usual 
orthodox treatment by internal medication up to July 7th, 1890, the date at which the pa- 
tient came under my observation. I found a subacute gonorrhoea, which was somewhat 
relieved by urethral injections, including the iodoform et tannic injection of Dr. Otis. 
On August 15th, 1890, the patient complained of difficult micturition, and upon ex- 
amining the urethral canal, I found the following condition. 
Size of urethra at bulb,No.32 French; 4 inches from meatus,a N0.21 sticture, meatus 
contracted to No. 20. 
The constriction at the meatus was relieved by incision, and the stricture readily 
yielded to gradual dilatation, and on August 31, 1890, a No. 31 sound was passed without 
pain. On September 1, 1890, an examination of the urethral canal showed the presence of 
a small ulcer at the side of the old stricture, and stimulating injections were ordered- 
without, however, relieving the "morning drop," This drop I examined microscopically, 
and found pus and mucus corpuscles, with small gonorrhoeal threads. 
On December 10, 1890, I again examined the urethra, and found the conditions about 
the same, I had tried the whole list of anti-gonorrhoeal remedies, including the medicated 
urethral bougies and the passage of steel sounds, and was somewhat puzzled to relieve the 
obstinate form which the disease had assumed. 
On January 26,1891,1 commenced the use of Marchand's Peroxide of Hydrogen, 15 
vol.,and "glycozone," with the following results: Two drachms of a mixture of R. Peroxide 
of Hydrogen, oz. ss, aqua. oz. iss, M., was used to distend the urethra, and held for thirty 
seconds, then allowed to escape. The decomposition of the H 3 O 2 was very active, show- 
ing the presence of pus. I then injected I drachm, which was allowed to remain in the 
canal two minutes. I repeated this procedure t. i. d., and at bedtime injected one drachm 
of "glycozone," This treatment was pursued up to February 9, 1891, when there was no 
discharge, and the patient declared himself cured. 
I had watched this case with great interest, for it was the most obstinate one I had 
ever seen in not yielding to some one of the many lauded cures for chronic gonorrhoea. 
During seven months the patient had been under constant treatment, to find that a three 
weeks' course of treatment by Peroxide of Hydrogen terminated the case quite satisfac- 
torily. 
The above data might naturally turn the reader's thoughts to the nature of the reme- 
dial agent that succeeded where all others had failed. 
The Peroxide of Hydrogen was that prepared by Chas. Marchand of New York. The 
chemistry of this compound together with the pathological conditions it may be applied 
to, I will leave to the many advertising agents and will simply state the care with which 
the preparation should be preserved; for there are factors which utterly destroy the 
medicinal properties of this valuable agent. 84 
PEROXIDE OF HYDROGEN AS A DEODORIZER, IN CAN- 
CER OF THE UTERUS. By GEORGE W. KAAN, M. D., 
Surgical to Out-Patients, Free Hospital for Women, Boston. 
(Published by the Boston Medical and Surgical Journal, April 7, 1892.) 
The value of peroxide of hydrogen in washing out sinuses and abscess cavities, has 
led me to use it recently as a vaginal injection in cancer of the uterus; and with gratifying 
results. 
My cases have been few; but in each the distinctive cancerous odor was noticeable 
about the patient before the use of the peroxide of hydrogen, and absent afterwards. In 
one out-patient case the fetor was so pronounced, that the air of the room seemed 
saturated with it, the moment she entered. When I last saw her in making an examination 
no odor was perceptible a foot from the vulva, and only slightly so close to it. I n this case 
she had used the injection the night before, and a cancerous mass as large as a man's 
fist, hangs in the vagina, within two inches of the vulva. This case has had palliative 
treatment in the hospital, by curretting, Paquelin's cautery, and chloride of zinc applica- 
tions. When she first came to me the disease had extended over the whole anterior 
vaginal wall; since then the peroxide of hydrogen has been used, and the anterior wall is 
clear. It seems to me that the injections have had some curative action. 
Further observation, of course, is necessary, but bearing in mind what Sir Spencer 
Wells says of cancer and cancerous diseases, that every thing in relation to it is so impor- 
tant that nothing should be thought a trifle, and my material being limited, I venture to 
state the facts as they appear to me in this case. 
Regardless, however, of any value it may have as a curative agent, its use as a deo- 
dorizer, and this without substituting another odor for the cancerous one, makes it of 
inestimable worth in adding to the comfort of the patient, where palliative treatment 
alone is all that remains. 
The method of using has been to take about an ounce of the peroxide of hydrogen 
and an equal quantity of water, warmed by being placed in a pan of hot water, and 
injected through a soft rubber catheter, so that the injection shall be sure to reach the 
back part of the vagina. Such an injection once or twice a day has been sufficient. 
PEROXIDE OF HYDROGEN AS A LOCAL APPLICATION IN 
RHUS TOX POISONING. 
PR. N. H. HAIGHT, Oakland, Cai. 
Published by The Homocpathic News, of St. Louis, Mo., July, 1892. 
May 20th, 1892, I was called to treat a young lady who was suffering from the 
effects of poison oak. She had been suffering for nearly a week, and had tried every- 
thing that friends had recommended, but continued to grow worse. The left side of 
her face was so badly swollen that the eye of that side was entirely closed and she was 
suffering intense itching and pain. 85 
I have never heard of Peroxide of Hydrogen being employed in such cases before, 
but not feeling satisfied with the treatment that I had used in the past, I decided to ex- 
periment on this case. I used Marchand's Peroxide of Hydrogen (medicinal), feeling 
sure that it would reduce the inflammation, and by so doing, it would naturally allay 
the itching. I used in the following proportions: Peroxide of Hydrogen, 1 part; dis- 
tilled water 2 parts; applied to the affected.parts every hour. I also gave internal treat- 
ment of croton tig. 200. The next morning I called to see how the case was progress- 
ing, and found her very comfortable, the itching and swelling being very much less. I 
continued the same treatment, and on the fourth day the case was cured. On another 
case I used H3 O2 1 part, tincture grendilla robusta 2 parts with equally good results 
but no better. 
MEDICINAL VS. COMMERCIAL PEROXIDE OE HYDROGEN. 
Salina, Kas., August 15th, i8<)2. 
To the Editor of the Medical Herald, St. Joseph, Mo.: 
Professional indifference and professional inactivity are probably the two greatest 
enemies to our individual progress in the profession. Whereas cultivation will alone fit 
us individually with that broad-guage knowledge, the practical appreciation of which 
marks, with lasting effect, the progress to success. Hence, earnest interest and labor 
are essential requisites, if we would learn to discriminate between the opportunities pre- 
senting, lest we cultivate a flowerless plant or we find weeds instead of roses when we 
look for success. This is aptly illustrated by the course pursued with regard to the 
selection of remedial agents by so many of us in the profession, from time to time, and 
probably in no instance more forcibly than in the use of Peroxide of Hydrogen, 
(H3 O3.) In this connection, I feel it but a personal duty to the profession to record 
my own experience with this agent, having for several years made use of Peroxide of 
Hydrogen in suitable cases (i. e. chiefly where pus formation was found), with very 
varying results. Like most of my brethren, I took it for granted that H3 O3 was the 
same, so long as it was made by our leading manufacturing chemists, and consequently 
paid no attention as to the effects of special brands, since I felt confident that my drug- 
gist was handling only the products of first-class manufacturers, and could distinguish 
between the "Commercial" and "Medicinal" articles. The result being that I was not 
impressed with anything like an absolute confidence in this agent to arrest pus formation. 
It was not till in October, 1891, when in attendance at the annual meeting of the Mis- 
sissippi Valley Medical Association in St. Louis, that in a personal interview with Dr. 
Charles Marchand, of New York, relative to the product of his manufacture, that I de- 
cided to give this agent another fair trial, and watching the effects carefully with refer- 
ence to the different makes in the market. This upon the avowed assurance of Dr. 
Marchand, that there was a most striking difference in the result of using the product of 
different manufacturers. After almost another year of numerous trials and careful, 
accurate observation with a number of different makes in the market, I am prepared to 
confidently endorse all that is claimed for the superiority of Marchand's make. I have 
used three different products alike in abscesses of almost every description, ulcers, gan- 
grene, cancer, endometritis, specific vaginitis, diphtheria, etc., etc., and in each and 
every instance Marchand's preparation proved above all, not only the most effectual, 
but in every way a most satisfactory agent for arresting pus formation, and as a non- 
irritating antiseptic for general use. Therefore, I most earnestly counsel my fellow 
co-laborers in the profession to be particular in specifying Marchand's Peroxide of Hy- 
drogen (medicinal) whenever this agent is called in use by them. 
W. B. Dewees, M. D. 86 
RETAINED NASAL SECRETION OR SYPHILITIC 
RHINITIS?* 
Published by the Medical Standard of Chicago, Ill., Oct., 1892. 
By C. E. PERKINS, M. D., Sandusky, O. 
Few cases of acute catarrhal rhinitis are sufficiently severe to compel a patient to 
consult a physician. When such cases occur the symptoms are severe and the diagnosis 
difficult. 
February 7, a 30-year-old unmarried woman, with negative family history as to 
tuberculosis, rheumatism or lues, consulted me. There was no evidence of lues. The 
patient had an attack of measles in 1891, from which she and five other members of the 
family recovered without results of any kind. Up to the commencement of this trouble 
she had been exceptionally healthy and robust, having never required the services of a 
physician. 
In the latter part of October last she was taken with what she considered an ordi- 
nary cold. There were the ordinary symptoms of acute catarrhal rhinitis, viz.: malaise, 
dryness and heat of the nose followed by discharge, etc., but she had in addition to all 
these a severe neuralgia on the right side of the face, which persisted for about a month. 
Early in December complete stenosis of the right side of the nose developed and the 
left was partially occluded. At this time there was a swelling across the nose, frontal 
and nasal pains, and slight epiphora, and there was very little running from the nose 
and that of a watery character. About these same symptoms continued until just before 
Christmas when she consulted her physician. I am quite certain that he considered the 
case as one of nasal syphilis, for he prescribed mercurial inunctions and insufflated 
iodoform daily. She continued under his care for six weeks. At one time in January 
she had a hoarseness for one week. The right nostril continued occluded, and the left 
became completely so, although he was adopting rigorous anti-syphilitic treatment. 
Not making any improvement she consulted me on February 9. I found her weak and 
anaemic and somewhat emaciated. There was complete loss of appetite, and swelling, 
redness and pains across the nose. , 
These pains were so severe as to interfere with sleep; there was complete stenosis 
of both nasal passages which caused the characteristic voice of nasal occlusion. This, 
upon inspection, appeared to be due to thickening and infiltration of the turbinated 
bodies and septum; they were in contact about one-fourth of an inch from the anterior 
nares. Having benumbed the parts with cocaine, I introduced a probe wound with cot- 
ton, beyond this point of contact and brought out some cheesy matter of disagreeable 
odor. I was unable to get a thorough view of the nasal cavities at that time, so I 
directed her to return on the following day; then I found the oedema somewhat sub- 
sided, and saw that there was a polypoid enlargement of the middle turbinated bodies 
which acted as a valve to imprison the decomposing material. 
This I removed with a cold wire snare, and thus opened up a regular cavity on each 
side, from which I removed at least an ounce of foul-smelling, cheesy pus. I might add 
that this accummulation was above the middle turbinateds so far as I could make out. 
As the parts were thus opened, and the discharge was enabled to make an exit, it gave 
rise, by running down into the throat, to a very distressing nausea. This I succeeded 
in relieving by daily removing these secretions and spraying the nares with a solution 
of Peroxide of Hydrogen ("Marchand's") one to four of water, and a mixture, taken 
internally, of pepsin and bismuth. I also prescribed champagne. Under this treat- 
ment the patient soon began to improve. She regained her appetite, the s'enosis was 
elieved, foetor stopped, and she began to gain in flesh and strength, and on March 4th 
Ohio Med. Soc. Trans. Cond. 87 
I permitted her to go home, some ten miles, to report occasionally; she continued to 
improve until March 24th when she returned complaining of obstruction in the right 
nasal cavity. Then I removed the last bit of decomposed mucus, which had become 
very much hardened; since which time she has remained well. I examined her on April 
26th and found the nasal cavities as nearly normal as we are accustomed to see them; 
there was no ulceration nor was there any perforation of the septum, or anything to sug- 
gest that a syphilitic process had been going on. 
TREATMENT OF DIPHTHER1A. 
Read Before the Massachusetts Homeopathic Medical Society. 
J. II. SHERMAN, M. D., Boston. 
Published by the Nezu England Medical Gazette, Boston, Mass., October, 1892. 
Intelligent treatment of diphtheria as well as intelligent treatment of other diseases 
presupposes true conceptions of the nature of the disease. I take it for granted, with 
the incontrovertible evidence on the subject, that the cause of the disease, diphtheria, is 
the introduction into the system of microscopic germs, bacteria. Without these germs 
no diptheria. The first point of attack is the natural one where in the act of breathing 
they would come in contact with the tonsils and soft palate or mucous membrane of the 
nose. In mild attacks the disease remains a local one, the general system becoming lit- 
tle affected. In the severe cases it extends to almost every organ in the body. 
On the supposition that the disease is caused by germs, then to cure the disease, 
we must destroy or antagonize them. Have we any remedy that will do this? Yes, 
several; bichloride of mercury is the chief, but doses sufficient to overcome the germs 
would be dangerous to the patient. We have long been looking for a remedy that 
would be a potent germ-destroyer and still one harmless to the patient. I believe that 
remedy is now found. Some four years ago there was sent to me a pamphlet treating 
of Peroxide of Hydrogen, and the author especially dwelt upon the efficacy as an oxi- 
dizer of pus. About this time I had a patient in the Homoeopathic Hospital under 
treatment for cancer of the cervix uteri, and asked one of the staff of the able corps of 
surgeons what he thought of Peroxide of Hydrogen as an application to the broken 
down cervix. His reply was that he did not think much of it; and having such great 
confidence in my friend's judgment, I relegated it to the list of the numberless nostrums 
that we are invited to investigate. A few months ago my attention was again called to 
this remedy by a circular of testimonials from men eminent in the profession, and from 
all schools of practice. These men had proven it to be a safe and certain germicide. I 
sent for a half pound bottle of this remedy and waited for a suitable case on which to 
test it. It soon came. On August 29, 1891, I was called to Mrs. B-, Athens Street, 
an unhealthy locality, with cesspool connecting with street sewer directly in front of the 
house, and the street a very narrow one. Found my patient in bed with history of three 
■days' illness, fever, malaise, sore and swollen throat. On looking into the throat I 
found tonsils, uvula, and soft palate covered with the characteristic diphtheritic deposit, 
and portions of it assumed that dark hue so characteristic of fatal cases, and almost 
certain to be followed by the septic form of the disease. There was much swelling of 
the sub-maxillary, sub-lingual, cervical and parotid glands. Deglutition was accom- 
plished with great difficulty, a considerable portion of any liquid swallowed returning 
through the nose. There were also prominent laryngeal symptoms, croupous cough, 
etc., showing that the disease had already invaded the larynx. From previous experi- 
ence in such cases my prognosis was unfavorable, for such cases are generally fatal even 
in good constitutions, under which head this patient could not be classed; her general 88 
health being rather below par. 1 began treatment by spraying the throat with March- 
and's Peroxide of Hydrogen (medicinal) by the means of a hand atomizer with hard 
rubber attachments, as metallic ones are oxidized by the remedy. The effect was im- 
mediately apparent on the diphtheritic deposit. 1 could see dissolution of the 
membrane about the thin edges, the fibrinous portion contracting into a smaller com- 
pass. The patient complained however of an extreme smarting sensation in the throat 
so that I felt obliged to dilute the peroxide with an equal quantity of water which did 
not seem to materially impair its efficacy. These inhalations or rather sprayings were 
repeated every two hours, and the time occupied at each seance from five to ten minutes. 
The dark necrotic condition had changed in twelve hours to the more common grayish- 
white deposit. From this time on there was a gradual diminishing of the exudation, 
although there was a persistent tendency to re-appearance of the membrane after it bad 
been removed. The only internal remedies given were arsenicum, bichromate of potash, 
and glycozone. 1'he arsenicum for the general condition of the system, the bichromate 
for the croupy or laryngeal complication, and the glycozone to destroy the bacteria, the 
ptomaines and leucomaines that may have found their way into the stomach, alimentary 
canal, the absorbent and circulatory systems. It was five days before the throat was 
free from diphtheritic deposit, and some eight days before the glandular swelling had 
subsided. There was but a remnant of the uvula left after the sloughing off of the 
membrane, and a loss of voice from the fourth to the fifteenth day. The patient was 
greatly prostrated from the first, and rallied rather slowly under the use of concentrated 
nutriment and mild stimulants. On the whole, considering the gravity of the case, the 
result was better than I have before witnessed in similar cases. 
Another case worthy of mention in this connection is the following: On March the 
31st, 1892, was called up very early in the morning to see Master Terrance V. Freeman, 
aged three years and three months. The father told me the child had been ill for about 
a week with what he and his wife considered an ordinary cold, but soon after midnight 
of the present morning he was seized with a distressing croupy cough. On visiting the 
little patient I found the characteristic croup symptoms were apparent. I made an ex- 
amination of the throat and found both tonsils covered with diphtheritic membrane. 
My prescription was bichromate of potash first decimal trituration in half a glass of 
water, and carbonate of ammonia, one drachm in four ounces of cinnamon water. These 
remedies were given in alternation every one and one-half hours, and the throat was 
sprayed every two hours, night and day, with equal parts of Marchand's Peroxide of 
Hydrogen and water by means of a hand atomizer with hard rubber attachments. This 
line of treatment was persisted in with alternate remission and exacerbation of the symp- 
toms for five days, when the disease seemed under subjection, 2nd convalescence secured, 
which continued uninterruptedly until the tenth day, when I discharged the case. This 
child was naturally a frail-looking child, though it showed a remarkable vitality through 
this severe and protracted disease. It was given from the first all the nutritious food it 
could be induced to take, consisting mostly of milk and bovinine. That it was diph- 
theritic croup was evidenced by the membrane detached and coughed up at different 
times during the disease. On one or two occasions the child nearly suffocated by the 
loose membrane being drawn into the larynx or trachea, and subsequently expelled. It 
is my opinion that this child would have died had it not been for the Peroxide of Hy- 
drogen. It may seem a difficult thing to spray a child's throat effectively for five min- 
utes at each seance, as the child will not voluntarily hold its mouth open. I overcame 
this difficulty by putting a fork-handle between the teeth on one side of the mouth, and 
having it held by an assistant standing behind the child and holding its head in position 
at the same time. 
I have used this remedy, Peroxide of Hydrogen, in several other cases of diph- 
theria of a mild form, which would not be of interest to report as they all made satisfac- 
tory recoveries, and probably would have under usual treatment. 
What is Peroxide of Hydrogen? "The name hydrogen dioxide expresses its com- 
position, and its formula H2O2 represents this name. Hydrogen monoxide, H2O, or 
water, can under certain conditions, be made to combine with a second molecule of oxy- 89 
gen, the result being a water-like liquid, HgOg." This agent is one and one-half times 
more potent as a germicide than corrosive sublimate and perfectly harmless. It is 
adapted to all zymotic diseases and suppurative processes. It will follow a pus sinus as 
a ferret will follow a rat, and be sure of destroying the pus and germs. 
I alluded to this remedy some months since at a meeting of the Boston Homoeopathic 
Medical Society, when the subject of Gonorrhoea was under discussion, and the editor 
of our much valued Gazette remarked that there was scarcely anything in medical liter- 
ature concerning it, and that what was known about the remedy came chiefly from the 
manufacturer. This caused me to look up the subject, and I find an amount of pub- 
lished testimony altogether to voluminous to be quoted. 
MEDICAL DEPARTMENT SURGEON-GENERAL'S OFFICE. 
Headquarters of the First Brigade Michigan State Troops. 
Tecumsch, Mich., Sept. 15th, 1892. 
Chas. Marchand, N. Y.: 
Dear Sir-I promised you I would write you further about the Peroxide of Hy- 
drogen (medicinal) manufactured by yourself. 
I have cured a great number of cases of throat diseases with it, and one case of 
severe cystitis in an old man of 70, which I had treated with mild solutions of corrosive 
sublimate for nearly two weeks; he was benefitted a little. I then used one-half ounce 
of your Peroxide of Hydrogen to a pint of boiled and strained rain water, 
and washed out the bladder thoroughly with this,-the man got up next day and was 
up every day after that, was well in three days with only the one injection or washing, 
it is worth its weight if used only in cases of cystitis. 
Yours truly, 
C. M. Woodward, Surg. General M. S. T. 
THE PEROXIDE OF HYDROGEN (MEDICINAL); AN INDIS- 
PENSABLE WOUND STERILIZER. 
by GEO. H. PIERCE, M. D., Brooklyn, n. y. 
Probably the use most frequently made of this preparation, is in the cleansing of 
pus cavities, and suppurating surfaces. Any trace of pus remaining in any recess which 
an ordinary douch will not reach, is at once sought out by the peroxide, decomposed, 
and brought to the surface, in bubbles of gas. It is useful in cleansing off ulcers, 
sloughsand gangrenous tissues, chancres, diphtheritic patches, etc., and in cleansing 
sinuses, and suppurating cavities, such as the pleural in empysema, and the uterus where 
there is putrid discharge, and in cleansing abscesses where either puncture or free incis- 
ion has been made, it is invaluable, clearing out the pus as nothing else can do. There 
is one class of disease where its local action as a cleanser must be seen to be appreciated; 
and that is as a disinfectant for foul gangrenous growths. In a case of extensive epi- 
theliomia of the face, where only pilliative measures were of use, I found the Peroxide of 
Hydrogen a very Godsend. This case was one of the most foul I had ever witnessed. 
When I first saw it, the odor from it was so great that it filled the house. It was cov- 
(Published by New England Medical Monthly, November, 1892.) 90 
ered with a cloth into which the discharge had accumulated, thus adding a greater bulk 
of fetid decomposition; and to add to the horror, for such it was, upon removing the 
cloth, the surface was swarming with maggots, as large and active, as may be found in 
a heap of decomposing garbage, and not only on the surface, but they extended deeply 
in sinuses below the ear where it was impossible to reach them, except as they would 
come to the surface. My first impulse was to invoke Beelzebub for some patent ex- 
terminator, but finding myself left to my own resources, I set about bringing destruction 
as best I could. As time was of some moment, I removed what I could reach with dress- 
ing forceps, then douched with bichloride, 1-1000, then with Peroxide of Hydrogen, 15 
vol. strength, rinsed this off with warm water, and douched again thoroughly, with per- 
manganate of potash solution, and finally dusted the whole with beechwood charcoal- 
which, in addition to acting as an absorbent to the gases, made an appearance very 
much to be preferred to the ordinary gangrenous appearance. I ordered the cloth to be 
left off entirely; first, because it only added an additional fetid surface, and second, be 
cause the growth was very vascular and would bleed easily on being disturbed. It was 
dressed morning and night, and henceforth was kept almost entirely free from odor. 
The same routine was gone through with each day. First, Peroxide of Hydrogen, 
which was applied by pouring it directly from the hottie in which it came, an absorbent 
cotton held by dressing forceps, so that it dropped directly on the growth; when im- 
mediately a white foam would cover the surface, from the disintegration of pus, gangren- 
ous shreds, blood, etc. Second, rinsing off with warm water, then with permanganate 
of potash sol. gr. ij., cupful of water, allowing it to drip from a wad of cotton over the 
surface. Third, dusting with charcoal and leaving it uncovered. An immense lot of 
Peroxide was consumed in this case, being purchased in £ lb. bottles, six at a time. This 
seems to me a very effective means of keeping clean these foul discharging growths of 
the carcinomatous class; the Peroxide and permanganate, being a most thorough disin- 
fecting combination; and if employed in any case of cancerous growth, where palliation 
alone must be relied on, will make that life and the lives of those closely associated with it, 
more endurable. One important fact remains in regard to the chemical properties of the 
Peroxide. To be effectual, it must be kept from the air, tightly corked, in a dark bottle, 
and in a cool place. It must be used directly from the original bottle. Do not permit 
the druggist to pour from one bottle to another when dispensing it, else the oxygen will 
escape, and it will be powerless. If when using, the white foam does not appear, it is 
because the preparation has lost its strength, and is absolutely of no use, of no more 
value than so much water. Ho O2 must be present. It is the additional atom of O 
combined with the H, that does the work, by giving up that nascent O for the purpose 
of oxidation. The strength should be 15 volumes. The preparation which I always use 
is Marchand's Peroxide of Hydrogen (medicinal). 
GLYCOZONE IN THE TREATMENT OE GASTRIC 
TROUBLE. 
(Extract from Doctor's Weekly, October 29th, 1892.) 
Editor of Doctor's Weekly: 
Dear Sir.-I received your paper this morning and was pleased to see a notice of 
glycozone. I have used it recently with great success in two cases of gastric trouble 
when almost all the useful remedies had failed, and with the happiest results. It is a 
perfect antiferment, relieving all the distressing dyspeptic trouble and aids digestion 
better than all the pepsins I have ever seen. Respectfully, 
Oliver D. Nostrand, M. D., 
Cincinnati, O., Oct. 22, 1892. 286 West Fourth St. 91 
PEROXIDE OF HYDROGEN AND ITS USE IN EAR 
DISEASES. 
Read tn the Section of Laryngology and Otology, at the Forty-third Annual Meeting 
of the American Medical Association, held at Detroit, Mich., June, 1892. 
{Abstract.') 
WALTER B. JOHNSON, M. D., of Paterson, N. J 
Surgeon to the Paterson Eye and Ear Infirmary 
(Published by the Journal of the American Medical Association, October 29th, 1892) 
The peroxide solution may be used advantageously in the treatment of mastoid 
disease after an incision has been made. The action of the remedy upon bone denuded 
of its periosteum, and even upon carious or necrotic bone, is unique; it causes a disinte- 
gration of the molecular particles and they are gradually subdivided and carried away 
in the frothy product of the chemical action, until a healthy surface appears upon which 
the solution seems to have only a beneficial effect. The action of the solution upon 
dead bone can be readily demonstrated by placing a small portion of necrotic bone in it; 
the bone in a short time will begin to disintegrate and continue to do so until it is en- 
tirely divided into very minute particles. 
In some of the cases of mastoiditis treated, in which the denuded surface was very 
extensive, in from three to six weeks the bone would be in a perfectly healthy condition, 
the discharge of pus controlled, and the subsequent closing of the wound, when allowed, 
occurred rapidly and was perfectly satisfactory. 
In one of the cases, in which for three years any attempt to allow the closing of 
the sinuses would be followed by an exacerbation of the inflammation, the carious con- 
dition was relieved and the opening allowed to close after two months of treatment. 
The treatment is very simple and consists in syringing through the opening and 
into the meatus with a small glass syringe a sufficient quantity of the fifteen volume solu- 
tion, at each sitting, to render the pus thoroughly aseptic, then packing the ear and the 
wound lightly with strips of sheet lint or gauze thoroughly soaked in the same solution, 
great care being taken to allow the wound to close, although the packing must not be so 
introduced that it will prevent the free exit of any pus which may be formed during the 
interval between the dressings. The external incision should be made ample and if the 
packing does not prevent the opening from closing during the progress of the treatment 
it must be reopened with the knife. Glycozone has been suggested for use in keeping 
the wound open, being used instead of the peroxide in the dressing. 
The result of this line of treatment which has been followed in a considerable num- 
ber of mastoid cases, has indicated the possibility of a degree of conservatism in the 
treatment of mastoid disease which is very desirable. 
All the cases treated have done well, no deaths have occurred and in no case was it 
considered necessary to scrape the bone or to remove any portion of it, while the period 
of time necessary for the wound to assume a sufficiently healthy condition to render it 
advisable to permit it to close, did not seem longer than the time which must ordinarily 
•elapse after the operation for thoroughly scraping the mastoid, and was much shorter 
than the time required before the wound produced in chiseling the mastoid could possi- 
bly be allowed to close. 
Special care should be taken to keep all the applicators or sprays, used either with 
the peroxide of hydrogen solution or glycozone, perfectly clean, especially in case of 
mixtures of glycerine and peroxide which should be made fresh every second or third 
day to prevent the possible formation of formic acid; only silver, hard rubber, glass or 
porcelain should be used for measuring purposes. 
If care is taken to properly keep the solutions, they are perfectly harmless and cal- 
culated to be of inestimable benefit to all who use them. 92 
THE OPERATIVE TREATMENT OF FISTULA IN ANO. 
Adjunct Professor of Diseases of the Rectum, Philadelphia Polyclinic and College for 
Graduates in Medicine. ' 
By LEWIS H. ADLER, Jr., M. D., 
Read before the Phil. County Medical Society, November 23d, 1892. 
Reprinted from the International Medical Magazine for October, 1892. 
After the operation of fistula in ano, I am in the habit of packing the wound with 
iodoform gauze, which is left undisturbed for twenty-four hours. This is done to pre- 
vent subsequent hemorrhage. A pad of gauze and cotton and a T-bandage are next 
applied. 
The subsequent dressing of the case should be daily attended to by the surgeon him- 
self. The parts should be kept perfectly clean, and the wound syringed with peroxide 
of hydrogen (Marchand's), carbolic acid solution, etc., after which a single piece of 
iodoform gauze laid between the cut surfaces of the wound will be all the dressing re- 
quired. 
In the after-treatment of these cases I have seen the healing process greatly retarded 
by the excessive packing of the wound with lint, or delayed by the undue use of the 
probe. Such interference is to be avoided. 
If the granulations are sluggish and the discharge is thin and serous, it will be well 
to apply some stimulating lotion, such as peroxide of hydrogen, or a weak solution of 
copper sulphate (two grains to the ounce). 
The surgeon should be on the watch during the healing process to avoid any burrow- 
ing or the formation of fresh sinuses. Should the discharge from the surface of the 
wound suddenly become excessive, it is evidence enough that a sinus has formed, and 
a careful search should be made for it. Sometimes it is under the edges of the wound 
that it commences, at other times at the upper or lower ends of the cut surface, and 
occasionally it seems to branch off from the base or the main fistula. 
Pain in or near the seat of the healing fistula is another symptom of burrowing, and 
when complained of, the surgeon should carefully investigate its cause. 
' After an operation for fistula, the patient's bowels should be confined for three or 
four days, for which purpose opium is usually given. At the end of this time the 
bowels may be opened by the administration of a dose of castor oil, and so soon as the 
patient feels a desire to go to stool, I am in habit of ordering an enema of warm water 
to be administered, which has a tendency to render the faeces soft and fluid and hence 
to make their passage easier. The patient should be kept in a recumbent posture until 
the fistula is healed and until the bowels are moved; the diet should be liquid such as 
milk, beef-tea, and broths. The time required for a patient to recover after an oper- 
ation for fistula in ano varies with the extent of the disease. In an average case it will 
be necessary to keep the patient in bed for two weeks, and confined to the house for a 
couple of weeks longer. 
THE AFTER-TREATMENT. 
ABSTRACT FROM A TREATISE ON DISEASES OF THE 
RECTUM, ANUS AND SIGMOID FLEXURE. 
By JOSEPH M. MATHEWS, M. D. 
Prof, of Principles and Practices of Surgery, and Clinical Lecturer on Diseases of the 
Rectum', Kentucky School of Medicine, Louisville, Ky. 
Page 188.-After the operation is performed, Dr. Mathews writes as follows: 
I then syringe the cavity out freely with a solution of bichloride of mercury (i to 
5000). Then a tent made of iodoform gauze is introduced into the cavity, just as much 93 
as it will hold. After the expiration of twelve hours, I withdraw the iodoform gauze 
and allow any accumulation to pour out freely. I have used the bichloride solution 
here first, because I believe it to be a good antiseptic and at the same time a good stim- 
ulant to the cavity. However, afterward I substitute another agent-viz., Peroxide of 
Hydrogen. Of course our great object in dealing with cavities of this kind are two- 
fold: First, to stop suppuration; second to heal the diseased structure. For prevent- 
ing suppuration, we have chiefly relied upon solutions of bichloride of mercury and car- 
bolic acid. Every surgeon is well aware of the fact that dangers attend the use of car- 
bolic acid in the treatment of suppurating diseases, and the too free use of the bichloride 
of mercury in large suppurative cavities might not only cause too much inflammatory 
action, but also produce a general effect upon the system which would be shown in 
ptyalism. We have in a strong solution of peroxide of hydrogen a substitute for these 
two without any of their attending dangers. Undoubtedly the best preparation of this 
agent is Marchand's Peroxide of Hydrogen (medicinal). His fifteen volume solution 
will retain active germicidal power for many months, if kept tightly corked in a cold 
place. It can be used, of course, in any strength that the surgeon desires. Marchand 
has devised a hand atomizer and ozonizer for the purpose of using the agent in an easy 
manner. 
The abscess cavity is injected once a day with this agent, either pure or diluted with 
water, from three to ten parts, and each time the tent of iodoform gauze is pushed 
gently into the external opening, but so as not to fill the cavity. As the healing pro- 
cess goes on, a less amount of gauze is used. If large rectal abscesses are treated in 
this manner, the number of cases of fistulae will be greatly reduced. 
SOME OF THE USES OF PEROXIDE OF HYDROGEN IN 
GENERAL SURGERY. 
THOMAS H. MANLEY, M. D., New York. 
Published by the Neiv England Medical Monthly, Danbury, Conn., Dec., 1892. 
Since Marchand placed on the market, a pure, unadulterated peroxide of hydrogen, 
and Morris of New York, called attention to the marvelous power of this preparation as 
a deodorizer, the profession have very generally employed it in such pathological condi- 
tions as will enable us to apply it directly to the diseased surfaces. In general medi- 
cine it has been employed on extensive scale in the phagedenic, sore throat of malig- 
nant scarlatina, diphtheria, and other maladies. 
In surgery, it has been particularly recommended in non-malignant, suppurating 
sores. 
Since it has now come to be very generally known, that with very few exceptions all 
chemical solutions of sufficient potency to kill germs, possess such irritating properties, 
as to interfere with healthy cellular proliferation, there has been a demand for some- 
thing which might nullify germ activity, and at the same time, in no way interfere with 
the recuperative energy in the histological elements. In a large class of cases peroxide 
of hydrogen seems to provide this want. 
In the Harlem Hospital and Dispensary service, the peroxide, Marchand's medicinal, 
is largely employed; and, in appropriate cases, with better results, than with any other 
agent. 
It seems to possess a special affinity for the lethal elements, in all suppurating pro- 
cesses, which tend to run into chronicity. 
We have largely employed it in those cases of fistular sinuses, so seriously resulting 
from suppurating lymphatic glands in children and adults; as well, as in those buboes 
which are sure to heal and discharge for a long time, a sero-purulent matter. 
The only class of sinuses in which its use should be employed with caution, are those 
in which the fistula extends, into a lesion in the osseous elements. 94 
In many cases, in which a long, deep rent has been made in the tissues, in strumous 
subjects, in which healing processes are delayed, its employment is very satisfactory, in 
-effecting primary union. Now, whether it acts as antiseptic; or, by imparting fresh 
vitality to the cells, is a question by no means settled. 
When we use it, it should be applied in such strength as different cases require. In 
foul smelling, copiously discharging processes, it may be used in a concentrated form, 
while in milder cases, particularly in children, it should be diluted. 
In my own private practice none has given me so much satisfaction as that manufac- 
tured by Chas. Marchand; and as we have seen in Dr. Squibbs' "Ephemeris," for this 
year, this preparation seems to be regarded by chemical analysis, to maintain a high 
and uniform standard of strength and purity. 
INTESTINAL OBSTRUCTIONS. 
DIAGNOSIS AND TREATMENT. 
By FREDERICK HOLME WIGGIN, M. D., New York. 
Attending Surgeon City Hospital, Blackwell's Island. 
(Abstract from the Medical Record, July 23, 1892.) 
Irrigation of Abdominal Cavity.-As to the irrigation of the abdominal cavity, 
the practice inclines toward the use of plain water or so-called normal salt solution, six- 
tenths per cent. My own experience and observation lead me to believe that many of 
the complications following laparotomy can be traced directly to the use of chemical 
solutions during the operation, either for irrigation, for disinfecting the hands of the 
operator, his instruments, or sponges. Ina case where the abscess is circumscribed, it 
is bad practice to irrigate, owing to the danger of infecting the general cavity. In all 
aseptic cases irrigation should be avoided. When irrigation is necessary, while the nor- 
mal salt solution is best, still in some cases, I believe, this may be followed by a second 
douche containing a small quantity of hydrogen dioxide. I have used it for several 
years in all kinds of surgical work, and once in the general abdominal cavity; in a case 
already alluded to (the patient dying shortly after the operation, no deduction can be 
drawn from it), and where pus was present, have found it in proper solution more effi- 
cient and less irritating than anything else. In some of the New York hospitals, it has 
been used for irrigating the pleural cavity in empyema, and it has proved satisfactory. 
I have been unable to find any record of a case where this compound has been used for 
irrigating the general cavity. In the letters already referred to, Dr. Senn says: "Have 
used the hydrogen dioxide in cases of limited peritonitis, and should not hesitate to use 
it in the diffused form." 
Dr. Mann says: "And I have never used hydrogen dioxide in the general cavity, but 
have applied it to the cut ends of tubes, holes in the intestines and bladder, etc., with 
good results." 
Dr. Clement Cleveland says: "I have never used the dioxide in the peritoneal cavity. 
I have used it pure in the uterine cavity, in puerperal septicaemia, with excellent results." 
Dr. Robert T. Morris writes: "In localized septic peritonitis, where I have occasion 
to expose directly the infected locality with retractors, I pour in the II2O2 in full 
strength and without any warming whatever. After allowing it to remain for a minute 
or two I sponge out and repeat, leaving the second lot for five minutes, sometimes not 
removing it at all, but putting my gauze wick down into it and allowing it to be sucked 
up at leisure by the drainage-wick. I have used it twice only in general septic peritoni- 
tis. One of the cases was an appendicitis (perforated), with the patient moribund at the 
time of application of the H3O2, I poured in a very large quantity, enough to bathe all 
of the abdominal organs; a very little hot water was poured into the peroxide just at the 
moment of using it, 'to take the chill off.' The peroxide was then siphoned out and the 95 
patient was made very much easier by the treatment, although he finally died. The 
other patient died too. The case was one of general septic peritonitis that had gone on 
to suppuration after removal of a gangrenous ovarian cyst. The post-mortem examina- 
tion showed that the HgOg had cleaned the cavity beautifully, and, although my patient 
died, I nevertheless obtained the impression that one has after such observations, that 
the HgO2 was very useful, and evidently quite harmless in itself. There are lots of 
cheap peroxides on the market that contain acids, and such would be harmful." (See 
article by Dr. Robert T. Morris, page 55, also article by Dr. F. H. Wiggin, page 75.) 
PEROXIDE OF HYDROGEN. 
Published by the Toledo Medical Compend, December, 1892. 
By L. C. SCHUTT, M. D., Toledo, Ohio. 
Referring to Peroxide of Hydrogen (medicinal) Dr. Schutt writes as follows: 
Diphtheria.-As a local application in this disease, Marchand's Peroxide of Hydro- 
gen (medicinal), can be used full strength, but in the majority of cases it is best to dilute 
it with from 20 to 30 per cent, of water. It may be applied with a brush or atomizer, 
and used as often as the severity of the case diay require. 
Pitting.OF Small-Pox.-The topical application of peroxide of hydrogen or glyco- 
zone is very beneficial. It allays the irritation of the skin and lessens the pitting and 
force of the disease. 
The local application of the peroxide in hay fever has proven very beneficial when mixed 
with an equal quantity of water and glycerine. It should be used at the very outset of 
the disease. 
As A Cosmetic.-When applied to the face it will make imperceptible a dark downy 
growth on the face when the hairs are numerous and fine and cannot be removed by elec- 
trolysis. It should be applied several timesa day with a camel's hair brush, until the hairs 
are thoroughly whitened and after that as often as necessary. The grease which adheres 
to every hair should be removed by applying a solution of powdered borax in water. 
In deep cuts and ulcers you will find the greatest benefit from the use of peroxide of 
hydrogen. 
I will report one case in which very decided benefit was obtained from the use of this 
preparation. 
Mr. P. O. H., a young man 23 years old. He received an injury, to his right hip, 
while helping to unload a cannon. It terminated in hip-joint disease, which confined 
him to the house for more than a year. Finally suppuration occurred, leaving him with 
two sinuses and several openings. All kinds of washes were used but the pus kept up. 
At last I commenced treating it with peroxide of hydrogen, using it pure and diluting it 
with water. We used it every day for seven months at which time all discharge of pus 
had stopped and the openings nearly closed. I am sure no other bactericide could have 
been used so long and with such good results, without injury to the parts or general 
system. IMPORTANT NOTICE. 
Owing to the large demand for Ch. Marchand's 
Peroxide of Hydrogen, medicinal, or Ozonized Wa- 
ter-imitations and substitutes are being forced on 
patients, when physicians do not especially specify 
on their prescriptions: 
CHARLES MARCHAND'S 
Peroxide of Hydrogen, 
15 Vol. capacity, medicinal, 
Ch. Marchand's Glycozone, 
therefore we respectfully call attention to this fact, 
which is, in many cases, the cause why good re- 
sults are not secured. By so prescribing, the pro- 
fession will be protected against unscrupulous 
druggists and manufacturers, who are base 
enough to place the physician's reputation, as well 
as the life of his patient in jeopardy, by substituting 
worthless imitations. 
Ch. Marchand's Peroxide of Hydrogen and 
Glycozone are put up only in 4, 8 and 16 oz. 
bottles, bearing his label and fac-simile. Both 
are intended to be used for a local antiseptic treatment. 
Consequently, they do not exclude the necessary inter- 
nal medication which may be prescribed by the physi- 
cian. Testimonials and general directions mailed free 
on application. CAUTION.-No metallic substance should come in contact 
with Ch. Marchand's Peroxide of Hydrogen or Glycozone, except 
silver, gold or platinum. Ch. Marchand's Peroxide of Hydrogen 
or Glycozone will not deteriorate if kept in a very cool place, such 
as a cellar or ice-box. 
PRICE-LIST. 
Ch. Marchand's combined Hand Atomizer and 
Ozonizer Per doz. $42.00 
PEROXIDE OF HYDROGEN. 
Solution C. P. medicinal, 15 volumes capacity. 
1 lb. bottles Per doz. $9.00 
8 oz. bottles. " 5.25 
4 oz. bottles " 3.50 
GLYCOZONE. 
1 lb. bottles Per doz. $36.00 
8 oz. bottles. " 21.00 
4 oz. bottles " 12.00 
RETAIL PRICES. 
1 Box containing 1 lb. Ch. Marchand's Peroxide 
of Hydrogen, 15 vol. medicinal, 1 lb. C. P. Gly- 
cerine, 1 Hand Atomizer and Ozonizer $5.00 
1 Hand Atomizer and Ozonizer 3.50 
PEROXIDE OF HYDROGEN. 
Solution C. P. medicinal, 15 volumes capacity. 
1 lb. bottle $ 75 
8 oz. bottle 50 
4 oz. bottle 35 
GLYCOZONE. 
1 lb. bottle $3.00 
8 oz. bottle 1.75 
4 oz. bottle 1.00 
Laboratory and Salesroom : 
ERNEST DREVET, 
No. 10 West Fourth Street, 
Bet. Broadway and Mercer St., NEW YORK. 
Liberal discount to the Trade. 
For Sale by all Reliable Druggists. OPINIONS 
OF THE I 
Medical Profession and Testimonials 
Medical Era, Chicago, April, 1886. 
" Hydrogen Peroxide." by W. W. Blackman, M. D 
Brooklyn, N. Y., in the Nor th A merican Journal of Homoeopathy 
" Abscess of the Frontal Sinus," by Dr. Goodwillie, in tl 
Medical Record, February 5, 1887. 
"Dioxide of Hydrogen," by Dr. J. Mount Bleyer, in th* 
New York Medical Record, August 13, 1887. 
" Some Clinical Notes on Diphtheria and the treatment b 
Peroxide of Hydrogen," by Dr. J. B. Hope, in the New Yor 
Medical Record, October, 1888. 
New York Medical Journal, February 2, 1889. 
Some practical hints in connection with intubation of the 
Larynx, by J. Mount Bleyer, M. D. 
" The use of Peroxide of Hydrogen and Glycozone in thera- 
peutics," by Ch. Marchand, E. C. P., in the Medical World of 
Philadelphia, Jan. 1, 1889. 
" Peroxide of Hydrogen as a germicide," by R. Charest, 
M. D., St. Cloud, Minn., published in the Medical World of 
Philadelphia, June, 1889. 
Mr. Chas. Marchand. New York, June 5, 1888. 
My Dear Sir :-Allow me to commend your manufactured 
peroxide of hydrogen and glycozone in the highest terms, as the 
most powerful of all antiseptics at present to me known. I have 
after making a trial with the above mentioned preparation in ove 
100 cases of diphtheria in my clinic at the Eastern Dispensan 
and with 40 cases of diphtheria which have undergone the operati' 
of intubation of the larynx by me, used in all these cited ca: 
ozonized vapor, and topical application with fine camels' h. 
brush of the 5 volume solution of peroxide of hydrogen every 
hours ; the solutions of glycozone were diluted in the sam 
strength only with chemically pure glycerine, and applied in th< 
same manner, only to repeat again with praise, that my expecta- 
tions of these preparations have been fully realized. These have 
been recommended bj' me to all my colleagues, and spoken of the 
results that were obtained with such harmless, non-poisonous, 
curative and powerful antiseptics. J|I make use of the peroxide of 
hydrogen and glycozone in my office practice for nose, throat and 
chest diseases, in all forms of application, as the ozonized vapor 
spray, local application, etc., with satisfaction to myself and 
patients, and hope that the further returns will agree with what 
my experience has taught me. In J whooping cough the ozonized 
vapor has rendered me extensive valuable service. I have the 
honor to remain, Dr. J. MOUNT BLEYER. Seward, Nebraska, Dec. 6th, 1886 
Mr. Ernest Drevet. 
Dear Sir:--I am well pleased with the action of the Ch. Man 
chard's peroxide that you sent me. If you have any new litera- 
ture on oxygen and its congeners, please send me some. Hoping 
to receive the peroxide as soon as possible, as I want to give it a 
test in the treatment ofdiphtheria. If you can give me anything 
new of its action in that disease would be pleased to receive the 
same. Yours truly, Dr. J. H. WOODWARD. 
Mr E. Drevet. New York, April 14th, 1887. 
Dear Sir :-Speaking personally, the Ch. Marchand's perox- 
ide used at the Hospital (Metropolitan Throat Hospital) gives 
the most perfect satisfaction, both as a disinfecting and cleans- 
ing agent, among the chronic and severe cases of nasal and 
pharyngeal affecton. I am unable to speak just yet in any posi- 
itive terms of its positive value in phthisis (so called) of the 
larynx, but merely judging from its action elsewhere, I must 
think it will have a very decided value as a spray application. 
Perhaps later on I can give you individual cases with results. 
Yours truly, Dr. G. B. HOPE. 
Indianapolis, Ind., Feb. 18th, 1887, 
Mr. E. Drevet : 
Send me by express, one dozen pound bottles of Ha Oa. 
Regarding glycozone, I consider that it will be of great use to 
surgeons. I have observed that, applied to old sores, it at once 
renders them bright colored, and soon encourages healthy action, 
by virture of its power as an oxygenizer. 
Yours truly, WM- B. CLARKE, M. D. 
Mr. Ernest Drevet. Boston, March 9, 1887. 
Dear Sir : I desire once more to express the satisfaction with 
which I view the results obtained from Ch. Marchand's hydrogen 
peroxide as furnished by you, and remain, very truly yours, 
H. E. SMALL, M. D. 
103 East 14th Street, New York, Dec. 22, 1889. 
Mr. E. Drevet. 
Dear Sir:-I am very much pleased to state that having had 
a persistent sore throat which I had unsuccessfully treated by 
some different ways. Since I have used Charles Marchand's P. of 
H. as a gargle I did recover in less than three days. I consider 
it a wonderful cure. Yours truly, E. BAYOT. 
Office of Julius Weille & Co., 151 Mercer Street. 1 
Mr. Ernest Drevet. New Yorr. April 4 1889. J 
Dear Sirs :-I am pleased to say that my sore throat, of which 
I have suffered terribly for the last 10 days, is considerably better 
since having used your Peroxide of Hydrogen Atomizer a.nd also 
Peroxide of Hydrogen as a gargle. I must say that I find it much 
better than Chlor, of Potash which I have used as a gargle right 
along with very little effect. 
I remain, yours vety truly, 
E. EISAMAN, 160 E. 108th St. Indianapolis, Ind., Feb. 5th, 1886 
Mr. Ernest Brevet. 
I find the Marchand's peroxide of hydrogen a very superior 
article, and shall take great pleasure in recommending it. Please 
send me, by express, 10 more 1 lb. bottles of the 15 volume, the 
freshest you have. Yours truly, 
WM, B. CLARKE, M. D. 
No. 2 W. Market Street. 
Chas. Marchand, Esq. Brooklyn, Jan. 21st, 1887. 
Dear Sir:-Your lettter was received yesterday. 
I have tried the glycozone with very gratifying results, and 
think it superior to the ordinary preparation of Hz Oz. 
I apply it as a dressing on absorbent cotton, to sloughing and 
ulcerated surfaces, and think it superior to any other preparation 
I have ever used for that purpose. Applied twice daily it keeps 
the diseased surface perfectly clean and sweet and rapidly stim- 
ulates healthy granulations. 
Its absolute purity does away with the necessity of neutraliz- 
ing the acid found in ordinary preparations of Hz Oz, and, 
therefore, makes it most valuable as a remedial agent. I generally 
apply as a dressing 2 volumes strong. In ulceration of the cervix 
uteri, applied on absorbent cotton, it is " safe, sure and speedy " 
in its action. Sincerely yours, Dr. W. W. BLACKMAN. 
E. Drevet, Esq. Holyoke, Mass., May 27, 1887. 
Dear Sir:-Last March I read a paper before the Vermont 
State Dental Society, entitled, " Growth, Development and 
Treatment of Alveolar Abscess." This paper will be published 
in the July number of the Independent Practitioner, and will be 
illustrated. Peroxide of hydrogen is my stronghold in the treat- 
ment of these abscesses, in fact, is my main reliance. I have used 
the peroxide a little over 15 months, but until 1 was at your place, 
the 13th of last month, I have had a great deal of trouble in get- 
ting it, and what I have had has been very weak. Among my 
dental friends the inquiry has been " where can we get good per- 
oxide of hydrogen ? " Since using Ch. Marchand's Peroxide I am 
very much pleased with it, and can heartily recommend it to my 
friends. Yours truly, GEO. A. MAXFIELD, D. D. S. 
1087 Elm Street, Manchester, N. H. 
Ernest Drevet, Esq. 
Dear Sir:-Please send me by first express one-half doz. lb. 
bottles of Ch. Marchand's peroxide ofhydrogen, 15 vol. C. P. for 
medicinal use. The last lot I obtained from you gave great satis- 
faction. There is a brand of P. of H. sold here that is far inferior 
to yours. I have tried it and it is almost worthless. 
Very truly, W. H. MERRY, M. D. 
Springfield, Mass., April 23, 1887. 
Dear Sir:-I wish Ch. Marchard's peroxide of hydrogen 15 
or 20 vols. I am much troubled to get that here which proves 
reliable, even when fresh. It has become one of my " hobbies." 
Dr. F. Y. Clark gave me your address. Yours sincerely, 
DR. C. T. STOCKWELL, M. D. Mr. E. Drevet. Seward, Neb., Dec. 23, 1886. 
Dear Sir:-I have been using the Ch. Marchand's peroxide as 
a local application to diphtheritic exudations, and as a dressing for 
pus discharging surfaces with unparalleled success. In my practice 
of twenty years' standing, I never have been acquainted with a 
remedy of equal potency in dissolving pus cell formation, and 
arresting the condition on which it depends. But I do not wish to 
be over sanguine, lest a wider experience with the remedy might 
disprove the apparent facts established. 
Respectfully yours, J. H. WOODWARD, M. D. 
Park Ridge, N. J., June 11th, 1887. 
C. Marchand, Esq. 
Dear Sir:-I have now used Ch. Marchand's hydrogen per- 
oxide and glycozone for some time. I have been surprised at the 
resu Its which I obtained by their employment as antiseptic agents 
when applied to ulcerated and gangrenous surfaces. In the treat- 
ment of all classes of wounds I consider them far superior to any 
of the most favorite methods now practiced, leaving the surface 
clean and free from pus, promoting healthy granulations in a very 
short period, and above all, is undoubtedly the cleanest dressing 
that can be had, as there is no bad smell when properly used. I 
have also used the peroxide with excellent results in ulcerative 
sore throat. In gonorrhoea I have used the glycozone as an injec- 
tion, with great satisfaction, the discharge ceasing immediately. 
I write these few lines to you to inform you of my first experience 
with these two remedies. My conclusions, so far, are that I shall 
never treat the above mentioned diseases in any other way after 
this than with them. I shall in a few weeks have prepared the 
history of several cases which I have now in treatment and which, 
I think, will prove beyond doubt, that in these two remedies we 
possess the most efficient means which we can desire, in the treat- 
ment of wounds and ulcerations. 
Yours truly, EUGENE JEHL, M. D. 
Nassau, Rensselaer Co., N. Y., Aug. 22,1887. 
Ernest Drevet. 
Dear Sir:-Your pamphlet of scientific reports on Chas. 
Marchand's Peroxide of Hydrogen sent to me at my residence in 
Albany was forwarded to me at this place. Accept thanks please 
for the same. We found your Peroxide of Hydrogen of great 
benefit to our little daughter. She now enjoys good health and 
her catarrh also is much better, so that it annoys her but little. 
Yours truly; GEO. H. KNOWLTON. 
New York, Sept. 10, 1887. I 
Mr. E. Drevet ; 12 W. 39th Street. j 
Please send me three dollars worth of Chas. Marchand's Per- 
oxide of Hydrogen, same as you furnished me last January, I 
found it an admirable article. Yours truly, 
HENRY C. HOUGHTON, M. D. Thomas H. Wood & Co., 573 & 575 Broadway, I 
Mr. Ernest Drevet. New York, January, 1889. J 
Dear Sir:-I have been for a long while afflicted with a 
bronchial trouble and have tried almost every kind of remedy with- 
out apparent relief till I heard of your Chas. Marchand's Peroxide 
which I have used with a most effective effect. I have not been 
troubled with my throat since. It is a solution worthy to be 
known. I remain, very respectfully, 
WM. H. CURRY. 
Mr. Ernest Drevet. Boston, Feb. 17,1887. 
Dear Sir : Will you kindly forward me by express, as soon 
as possible, one-quarter dozen Ch. Marchand's hydrogen peroxine 
(15 vol. Med., use). The package I received some time since I 
divided among three patients of mine, and to say that I am 
charmed with its action but feebly expresses it : I am already 
enthusiastic. Very truly, H. E. SMALL, M. D. 
Mr. Drevet. On Board of Yacht " Dauntless." 
I am sorry that the yacht lays in such a position in the river 
off 38th street, that there is no convenience to get ladies on board. 
Please accept my thanks for your remedies, Ch. Marchand's 
peroxide of hydrogen and glycozone. They acted like a charm 
on my leg. In two days the suppuration ceased and scab formed, 
so that my shin is almost well. Goodbye. Yours truly, 
CAPT. S. SAMUELS. 
Morgan Park, Cook Co., Illinois, Jan. 10, 1887. 
Ernest Drevet, 10 W. 4th St., N. Y. 
Dear Sir:-Having received one of your pamphlets and lik- 
ing the statements therein, and also having seen some of the good 
effects produced by Chas. Marchand's Peroxide of Hydrogen, I 
purchased a pound bottle from Gross & Delbridge in Chicago. 1 
have already used it in some cases of ulcer, in uteris (cervix) and 
also in otitis media, and I think well of trying it fully in my 
practice. I do not believe in caustics, etc., in chronic ulcers, etc., 
and I do believe in oxygen and hope that Hydrogen Peroxide will 
prove all claimed for it and more. Very truly, 
F. OLIN PEASE, M. D. 
Olean N. Y., Oct. 3, 1887. 
Ernest Drevet, 10 W. 4th St., N. Y. 
Sir:-Inclosed please find draft for $2.50. Please send me 
one pond of Ch. Marchand's Peroxide of Hydrogen, 15 volumes 
solution, and one-half pound of Glycozone. The Peroxide of 
Hydrogen received a few weeks ago is a splendid preparation, and 
has done me noble service. Please ship by express as soon as 
possible, as I am nearly out. 
Very respectfully, J. F. STEYNER, M. D. 
Newark, N. J., Oct. 18th, 1887. 
Mr. Ch. Marchand, 10 W. 4th St., N. Y. 
The bottle of Peroxide of Hydrogen sent proved very satis- 
factory. Please send a pint of the same, etc., 
Yours truly, ELEANOR HAINES, M. D. Charles Marchand. Esq. New York, November 4th, 1887. 
Dear Ser:-I will bring to your kind notice a fact that may be 
useful to your business and to many of your patrons. 
Under the skillful treatment of Dr. J. Mount Bleyer, No. 91 
Second Avenue of this city,I have been entirely cured in less than 
ten days of otitis media and mastoid abscess of the left ear, by the 
only use of your Peroxide of Hydrogen solution and the local 
application of your Glycozone. 
I was operated by Dr. Alfred Martin, an eminent specialist in 
Paris, France, on the 81st day of August last; the ulcer was kept 
open with a rubber tubing for 45 days and the suppuration was 
profuse. 
After five days of treatment with Peroxide of Hydrogen and 
the local application of Glycozone; healthy granulations were 
noticed, and the ninth day I was perfectly cured. 
Allow me. dear sir, to thank you for the so valuable antiseptic 
properties of your Peroxide of Hydrogen Glycozone, and believe 
me, yours most grateful. A. JACOUTOT. 
348 W. 51st St.,N. Y. 
Boston, Nov. 12th, 1887. 
Mr. Ch. Marchand, 10, W. 4th St.,N. Y. 
Enclosed please find $1.50 for which send us two lib. Dottie of 
your Peroxide of Hydrogen medicinal. 
Dr. C. H. Estabrook has given us a small quantity for trial 
and the results thus far seem favorable in a person of 80 years, etc. 
W. S. FOLGER & CO. 
723 Tremont St., Boston, Mass. 
Mr. Ch. Marchand. St. Louis, Dec. 23d, 1887. 
1 use the Peroxide of Hydrogen very much in diphtheria and 
have always had trouble to find a reliable article. 
I shall use Ch. Marchand's Peroxide exclusively hereafter. 
T. GRISWOLD COMSTOCK, 
507 W. 14th. St. 
Topeka, Nov. 21st. 1888. 
Mr. E. Drevet, 10 W. 4th St., N. Y. 
1 have never used anything (Ch. Marchand's Peroxide of 
Hydrogen) that gives me such universal success in the treatment 
of diphtheria, catarrh and many other equally difficult diseases to 
treat successfully. I really do not know what I would do without 
it, only a few months ago, I would not have promised cures that 
I now have no hesitancy in guaranteeing a cure. To me it ap- 
proaches wonderland. I have done so much with it that it startled 
me, that I do not now think anything impossible in this thera- 
peutic sphere. W. T. BRANSTRUP, 
Secretary Board of Health. 
E. Drevet, Esq., Brooklyn, N. Y. July 14th, 1888., 
Dear Sir:--Please deliver to bearer two bottles Cn. Marchand's 
Peroxide of Hydrogen. I have used it in bronchitis and consump- 
tion with gratifying results. Yours truly, 
E. H. MUNCIE, M. D. 
163 Tompkins Avenue. Baltimore, February 33rd, 1888. 
E. Drevet, Esq. 1734 Bolton Street. 
I have been using Ch. Marchand's Peroxide of Hydrogen for 
some time as ordered through Lilly, Rogers & Co. of this city, 
with very great benefit. When its value becomes better known by 
members of our own profession and others, I have no doubt you 
will have a large sale, and I am persuaded there is more virtue in 
it than the medical profession has ever dreamt of. 
Truly yours, W. R. MONROE, M. D. 
E. Drevet. Brooklyn, N. Y., March 1, 1888. 
Dear Sir:-My physician procured for me a bottle of Ch. 
Marchand's Peroxide of Hydrogen and directed me to use it on my 
leg, which was recovering from a sore resulting from blood poison- 
ing for which he had successfully treated me. 
I got a second bottle through my druggists which was in all 
respects like the first and my leg healed rapidly and well. 
On ordering a third, my druggist brought it to me in person, 
saying he had procured it from the wholesale house from which he 
bought all his goods, and that although in a different package, it 
was the identical solution that you put up in bottles that he had 
before. I was at first doubtful about it, but he so strongly as- 
sured me that he believed it to be all right, that I began to use it. 
I noticed soon after that, what appeared to be blisters came 
on my flesh outside of the new flesh circle which had healed. I 
write therefore to ask if this wholesale house foists off an inferior 
article, used for commercial purposes, on suffering humanity, as 
your standard preparation. If so, it will injure your reputation, 
and add to the affliction of those already suffering. 
Yours truly, DUNCAN B. CANNON, 
Secretary and Treasurer, Brooklyn City and Newtown R. R. Co. 
Great Bend, Kans. Dec. 13th 1887. 
Ernest Drevet, Esq. 
Dear Sir:-The Ch. Marchand, Peroxide of Hydrogen sent 
me is a charm. It is my stronghold in the treatment of all abscesses, 
alveolar, etc., in which cases I have had under treatment since I 
received it, my results have been a quick success in every case. 
I must heartily recommend it to dental profession. 
The Ch. Marchand's Peroxide of Hydrogen is an excellent pre- 
paration, no professional man should be without it. 
Dr. JNO. C. WALKER. 
Oakland California, Nov. 15, 1887. 
Ernest Drevet, Es<j. 
Dear Sir :-I wish to say that we are now using Ch. Mar- 
chand's Peroxide of Hydrogen and are more than pleased. 
Yours respectfully, Drs. ARNOLD & BOUGHTON. 
E. Drevet, Esq. Newark, N. J., Nov. 18th, 1887. 
The bottle of Ch.Marchand's Peroxide of Hydrogen sent to me 
proved very satisfactory. E. HAINES, M. D. Ernest Drevet, Esq. Boston, January 17 1888. 
I am pleased with the results of Ch. Marchand's Peroxide of 
Hydrogen used as a therapeutic agent, and have done my part in 
Boston among our pharmacists to draw their attention to it as I 
made inquiries at all our first-class houses and found I could not 
obtain it. Dr. Blackman was the first person to call my attention 
to it, and from the high recommender he gave I was lead to use it 
in a minor surgical case a year ago. It delighted me and I do not 
feel equipped tn my office without it now. Yours respectfully, 
Dr. J. K. CULVER, 698 fremont St. 
Indianapolis, Ind., Jan. 4th, 1888. 
Ernest Drevet, Esq. 
Dear Sir:-We have used Marchand's Peroxide of Hy- 
drogen in the past and liked it very much, but by some means 
were induced to try a Peroxide manufactured in St. Louis which 
we thought to be a good article for a time. 
Now we have decided to return to the Marchand's Peroxide 
of Hydrogen and wish you to send us one dozen 1 lb. bottles at 
your earliest convenience. Yours, 
O. S. RUNNELS, M. D., 50 Circle Street. 
Cambridge, Mass., February 9,1889. 
Ch. Marchand, Esq. 
Dear Sir:-I am glad to learn that you have decided to put 
up your Peroxide of Hydrogen in 4 oz. bottles. 
I think that this departure will be appreciated by the dental 
profession as soon as it becomes known. Dentists have heretofore 
had great difficulty both in procuring and keeping such a desirable 
compound. Now we shall be enabled to have afresh supply to 
uncork at more frequent interval. DR. H. E. CUTTER. 
E. Mock & Co., 173 Mercer Street, | 
New York, January 17th, 1889. f 
Mr. Ernest Drevet, 10 W. 4th St., City. 
Dear Sir:-According to my promise to let you know the re- 
sult of using Chas. Marchand's Peroxide, I am happy to say that 
after a week's application of same according to directions given, 
I find the soreness in my throat to have entirely disappeared and, 
furthermore, that it proved very beneficial in relieving the catarrh 
in my head, which I think, after using the Peroxide a little while 
longer will entirely disappear also. 
1 consider it a marvelous remedy and one that ought to re- 
ceive universal recognition, and I for one will surely recommend it 
to any of my friends similarly afflicted as I was. 
Yours respectfully, M. FRANK. 
Cohnfeld Company, 83 & 85 Greene Street, ) 
Mr. Ernest Drevet. New York, February, 1889. f 
Dear Sir:-I am pleased to inform you of the great success I 
have obtained from the Ch. Marchand's Peroxide which I got from 
you, that has saved my boy's life, for he had the worst kind of 
diphtheria. Last November I lost one of my boys from the same 
disease, and I greatly regret in not knowing about your Peroxide 
before. I might also have saved his life. 
I remain yours respectfully, WILLIAM JONES. New York, June 6th, 1889. 
Mr. Ernest Drevet, 10 W. 4th Street, N.Y. 
Dear Sir:-I desire to inform you that I have just now 
received a letter from a lady friend who was greatly troubled with 
the hay fever. On my recommendation she has used Charles 
Marchand's Peroxide of Hydrogen and Glycozone with the most 
gratifying results, and compliments me for the good advice I gave 
her in making use of that antiseptic. As for myself, my catarrh is 
getting better every day. I am now so much convinced about the 
properties of that wonderful remedy, that I will make it a great 
pleasure to recommend it to my friends. 
I remain truly yours, (Signed) P. A. JEANNOT, 
134 W. 95th Street. 
Chas. Marchand, Esq. New York, June 11, 1889. 
Dear Sir : - I have used your preparation of Peroxide of 
Hydrogen and Glycozone for all species of skin diseases, wounds 
and inflammations, with the greatest success, and with results sur- 
prising to myself and every one of the medical fraternity to whom 
I related some of the cases. They (the preparations) cannot be 
too highly praised, and no physician should fail to employ them 
in his practice. Yours, H. FRANK, 
36 Elm Street, City. 
New York, June 15th, 1889. 
Mr. E. Drevet, 10 W. 4th St. 
I have been troubled for a long while with pimples on my 
face, and after having tried unsuccessfully a number of remedies 
that had been recommended, I did not find any relief. 
I Anally concluded to try Chas. Marchand's Peroxide of 
Hydrogen, and I am pleased to state that I have been cured 
thoroughly in a very short time by the use of this antiseptic. 
Yours truly, B. P. DUCAS, 
56 Front Street. 
New York, June 15th, 1889. 
Mr. Chas. Marchand, 10 W. 4th St. 
Dear SirI received a gun-shot wound in 1864. A few 
weeks ago, my sufferings were so great that I was decided to fol- 
low the advice of several surgeons who wanted to amputate the 
leg. However, I tried your preparations of Peroxide of Hydro- 
gen, medicinal, and Glycozone, with marvelous effect; the second 
application gave me relief, and since then, I have been entirely 
free from pain and my sore has improved amazingly. I feel con- 
fldent it will effect a cure, and would cheerfully recommend its use 
to all who may be afflicted with any ailment for which it is recom- 
mended. 
I consider it simply invaluable and cannot say too much for it. 
Yours truly, R. SCHWAB, 
Of late Co. D, 24th N. Y. Cav. 
433 Strawberry Avenue, Harrisburg, Pa. Mr. Chas. Marchand. Newark, Oct. 5th, 1887. 
Dear Sir :-In reply to your letter on the 5th, I will say that 
the '"Glycozone" has had a good trial in nasal treatment. I 
found its results gratifying. I remain, yours respectfully, 
H. L. KNAUBER, M. D. 
No. 411 Hampshire Street, 
Quincy, Ills., Nov. 15,1886. 
Ernest Drevet, 
No. 10 West 4th Street, New York. 
Dear Sir:--Your favor at hand. Concerning the Chas. 
Marchand's Peroxide, I must admit that I find it far superior to 
any other make. 
Yours truly, 
C. E. EHRINGER, M. D. 
New York, April 13th, 1889. 
Mr. Ch. Marchand, 10 W. 4th Street. 
Dear Sir :-I hereby certify that after having suffered from 
a large herpes with suppurating ulcers, on the front part of my 
leg, during the last twelve months, I have been treated unsuccess- 
fully by several physicians. 
I have been advised to try Ch. Marchand's Peroxide of 
Hydrogen and Glycozone, and after five weeks of treatment I 
was thoroughly cured. 
I must confess that your preparations are wonderful, and any 
one who will try them once will be surprised by their healing pro- 
perties. Yours respectfully, JOSEPH REMY, 
No. 29 6th Avenue, N.Y. 
New York, April 22d, 1889. 
Mr. Ernest Drevet. 
Dear Sir:-Permit me to thank you for the bottle of Ch. 
Marchand's Peroxide of Hydrogen you sent me, and allow me 
herewith to send you the forfeit I agreed to give you if your 
remedy would cure my cough and sore-throat. You can refer to me 
at any and all times to indorse it, although I think it hardly 
necessary, as one trial would speak for itself. 
Yours respectfully, ED. SCHIRMER. 
209 Centre Street. 
125 East 25th Street, New York, June 6th, 1889. 
Mr. Ch. Marchand. 
In reply to your favor, relating to our experience in the 
French Hospital with your Peroxide of Hydrogen and Glycozone, I 
will state that after a year's trial in a great many cases of obstinate 
chronic ulcers, carbuncles, and wounds of all types, we have 
obtained such favorable results that we now employ them almost 
exclusively. 
Their advantage over other desinfectants and antiseptics is, in 
my estimation, their easyTapplication, quick action and freedom 
from danger of absorption. 
Yours very truly, J. J. HENNA, M.D. IMPORTANT NOTICE 
TO THE 
PROFESSION AND TO THE PUBLIC. 
Owing to the large demand for Ch. Marchand's Peroxide 
of Hydrogen, medicinal, imitations and substitutes are being 
imposed on patients, when physicians do not especially spe- 
cify on their presciptions: 
CH. MARCHAND'S Peroxide of Hydrogen, Medicinal, 
CH. MARCHAND'S Glycozone, 
therefore, I respectfully call attention to that fact, which 
is the cause, in many cases, that good results are not secured. 
By so prescribing, the profession will be protected against 
unscrupulous druggists and manufacturers, who are base 
enough to place the physician's reputation, as well as the 
life of his patient in jeopardy, by substituting worthless and 
injurious imitations which are intended to be used exclu- 
sively for technical purposes. 
Ch. Marchand's Peroxide of Hydrogen and Glycozone 
are pul only in 4,8 and 16 oz. bottles bearing his label 
and fac-simile. RETAIL PRICES. 
1 Box containing 1 lb. Ch. Marchand's Peroxide of 
Hydrogen, 15 vol. medicinal, 1 lb. C. P. Glycerine, 
and 1 Hand Atomizer and Ozonizer $5.00 
1 Hand Atomizer and Ozonizer 3.50 
PEROXIDE OF HYDROGEN GLYCOZONE. 
(Medicinal). * lb Bottle $ 1.00 
zi-lb. Bottle 35c 
%-lb. Bottle 50c *-lb. Bottle 1.75 
1-lb. Bottle 75c 1-lb. Bottle 3.00 
Laboratory, 10 West 4th Street, New York. 
When you cannot procure Ch. Marchand's preparations in 
their original packages at your druggist, send money order to 
" Ch. Marchand " at the above address, and shipment will be 
made by express. 
These remedies are put up in glass and cannot be mailed. 
TO THE MEDICAL PROFESSION. 
In order to prevent the profession being imposed upon, I 
respectfully call attention to the fact that 1 am the sole manu- 
facturer of Peroxide of Hydrogen (Medicinal). 
The commercial article should be used only for bleaching 
purposes, and is neither fit nor safe to use as a medicine on 
account of the poisonous substances contained therein. In my 
medicinal preparation, all poisonous substances are eliminated. 
A number of samples offered in the market by unscrupulous 
druggists are wholly unfit for medicinal use, and much has been 
sold under the name of it, that contained no Peroxide of 
Hydrogen at all. 
Marchand's Peroxide of Hydrogen, and Glycozone are put up 
only and separately in X'lb., ^Llb., and i-lb. bottles bearing my 
label and signature. Both are absolutely harmless. Insist upon 
getting these wonderful remedies in their original packages, and 
you will never be disappointed. . 
Chemist and Graduate of the " Ecole Centrale des Arts et 
Manufactures de Paris " (France'). Press of J. J. Little & Cd. 
Astor Place, New York, RETAIL PRICES. 
1 Box containing 1 lb. Ch. Marchand's Peroxide of 
Hydrogen, 15 vol. medicinal, 1 lb. C. P. Glycerine, 
and 1 Hand Atomizer and Ozonizer $5.00 
1 Hand Atomizer and Ozonizer 3.50 
PEROXIDE OF HYDROGEN GLYCOZONE. 
1 (Medicinal). -lb. Bottle $1.00 
%-lb. Bottle 35c 
^-lb. Bottle 50c -lb. Bottle 1.75 
1-lb. Bottle 75c 1-lb. Bottle 3.00 
Laboratory, IO West 4th Street, New York. 
When you cannot procure Ch. Marchand's preparations in 
their original packages at your druggist, send money order to 
" Ch. Marchand " at the above address, and shipment will be 
made by express. 
These remedies are put up in glass and cannot be mailed. 
TO THE MEDICAL PROFESSION. 
In order to prevent the profession being imposed upon, I 
respectfully call attention to the fact that 1 am the sole manu- 
facturer of Peroxide of Hydrogen (Medicinal). 
The commercial article should be used only for bleaching 
purposes, and is neither fit nor safe to use as a medicine on 
account of the poisonous substances contained therein. In my 
medicinal preparation, all poisonous substances are eliminated. 
A number of samples offered in the market by unscrupulous 
druggists are wholly unfit for medicinal use, and much has been 
sold under the name of it, that contained no Peroxide of 
Hydrogen at all. 
Marchand's Peroxide of Hydrogen, and Glycozone are put up 
only and separately in X-lb., and i-lb. bottles bearing my 
label and signature. Both are absolutely harmless. Insist upon 
getting these wonderful remedies in their original packages, and 
you will never be disappointed. ~A .. 
Chemist an J Graduate of the "Ecole Centrale des Arts et 
Manufactures de Paris " {France). The Therapeutical Applications 
OF 
Peroxide of Hydrogen 
(MEDICINAL), 
and Glycozone 
BY 
CHARLES MARCHAND, Chemist, 
GRADUATE OF THE " ECOLE CENTRALE DES ARTS ET MANUFACTURES 
DE PARIS" (FRANCE). 
TREATMENT OF DISEASES CAUSED. 
BY 
GERMS, BACTERIA, MICROBES. 
NEW YORK 
1892. RETAIL PRICES. 
For goods delivered in New York. 
I Box containing I lb. Ch. Marchand's Peroxide of 
Hydrogen, 15 vol. medicinal, 1 lb. C. P. Glycerine, 
and 1 Hand Atomizer and Ozonizer $5.00 
1 Hand Atomizer and Ozonizer $3.50 
PEROXIDE OF HYDROGEN GLYCOZONE. 
(Medicinal) 
%-lb. Bottle 50c %-lb. Bottle $1.00 
^-lb. Bottle 75c H-lb. Bottle 1.75 
i-lb. Bottle $1.00 i-lb. Bottle 3.00 
Laboratory, 28 Prince Street, New York. 
When you cannot procure Ch. Marchand's preparations in their 
original, unbroken packages at your druggist, send money order to 
"Ch. Marchand" at the above address, and shipment will be made by 
express. 
These remedies are put up in glass and cannot be mailed. 
Should you have been imposed upon by anyone who substituted 
spurious preparations instead of the genuine article, please report to 
me, so that I may expose and prosecute such consummate fraudulent 
dealers. I want to protect the physician, his patients as well as my- 
self. 
The United States Army Hospitals use Ch. Marchand's Peroxide 
of Hydrogen (medicinal) exclusively. The Therapeutical Applications 
OF 
Peroxide of Hydrogen 
(MEDICINAL), 
and Glycozone 
BY 
CHARLES MARCHAND, Chemist, 
GRADUATE OF THE " ECOLE CENTRALE DES ARTS ET MANUFACTURES 
DE PARIS" (FRANCE). 
TREATMENT OF DISEASES CAUSED 
BY 
GERMS, BACTERIA, MICROBES. 
FIFTH EDITION. 
NEW YORK 
1893. RETAIL PRICES. 
For goods delivered in New York. 
I Box containing I lb. Ch. Marchand's Peroxide of 
Hydrogen, 15 vol. medicinal, 1 lb. C. P. Glycerinej 
and 1 Hand Atomizer and Ozonizer $5.00 
1 Hand Atomizer and Ozonizer $3.50 
PEROXIDE OF HYDROGEN GLYCOZONE. 
(Medicinal) 
% -lb. Bottle 50c %-lb. Bottle $1.00 
^-lb. Bottle 75c J^-lb. Bottle 1.75 
i-lb. Bottle $1.00 i-lb. Bottle 3.00 
Laboratory, 28 Prince Street, New York. 
When you cannot procure Ch. Marchand's preparations in their 
original, unbroken packages at your druggist, send money order to 
"Ch. Marchand" at the above address, and shipment will be made by 
express. 
These remedies are put up in glass and cannot be mailed. 
Should you have been imposed upon by anyone who substituted 
spurious preparations instead of the genuine article, please report to 
me, so that I may expose and prosecute such consummate fraudulent 
dealers. I want to protect the physician, his patients as well as my- 
self. 
The United States Army Hospitals use Ch. Marchand's Peroxide 
of Hydrogen (medicinal) exclusively.