ii^'^^V'fc.V/W. .V: >r-ty. ->l >•.-/'■\.'t-.v. .• •,■;',-.■ rt'.v. v ■:. #»iifet::^j,..?.:,.,,v, ^>.yA^..,';.'>:.-.-.-,r,av.'' ■■7?!ft)-A *'■;:;>.•.•, .-<• •■fi.'-.|.V .^-^.c.^r-.-A"^':' i .■.■ r.v*f^.'*.v....-' NATIONAL LIBRARY OF MEDICINE NLN DDIQ^DL* D SURGEON GENERAL'S OFFICE LIBRARY Section ... Form 113c No. W.D..S.G. O. S ** CJ GOVERNMENT PRINTING OFFICE NLM001046040 V.; A MANUAL PKACTTCE OF MEDICINE, PREPARED ESPECIALLY FOR STUDENTS. BY A. A. £JEVENS, A.M., M.D., LECTURER ON TERMINOLOGY AND INSTRUCTOR IN PHYSICAL DIAGNOSIS IN THE UNIVER- SITY OF PENNSYLVANIA; DEMONSTRATOR OF PATHOLOGY IN THE WOMAN'S MED- ICAL COLLEGE, PHILADELPHIA; PHYSICIAN TO ST. MARY'S HOSPITAL, TO THE OUT-PATIENT DEPARTMENT OF ST. AGNES' HOSPITAL, AND TO THE SOUTHEASTERN DISPENSARY, PHILADELPHIA. ---" is an arch where through Gleams that untravelled world whose margin fades Forever and forever as we move." /■ a* ^r "Ov , ■ THIRD EDITION, REVISED, V. OF .^c- - V — V ILLUSTRATED, PHILADELPHIA: W. B. SAUNDERS, 925 Walnut Street. 1894. -34'I n, IS S'4- Copyright, 1892. By W. B. SAUNDERS. Copyright, 1891 PRESS OF W. B. SAUNDEES. PREFACE TO THE FIRST EDITION. Pope says, " Half our knowledge we must snatch, not take." If this be true of general knowledge, it is certainly true of the knowledge of medicine as it is taught in the schools of to-day. In view of this fact, there seems to be a real need for books which present their subjects in an assimilable form. At the request of many students the author has written this book with the hope that it may serve as an outline of Practice of Medicine, which shall be enlarged upon by diligent atten- dance upon lectures and critical observation at the bedside. In its preparation the ■ ^wii'tibgs>. of„ the following authors have been freely consulted : Striimpell, Osier, Fagge, Bristowe, Frerichs, Liebermeister, Vierorclt,. Eichhorst, Wood, Boss, Gowers, Sansom, Henry, Tyson, Pepper, Paul, Murrell, Starr, Hilton, Duhring, Stelwagon, Van Harlingen, Tilbury Fox, Hardaway, Seiler, Cohen, Browne, Jacobi, Bruce, Brunton, Charcot, Dujarden-Beaumetz, Pavy, Mitchell, and Trousseau. PREFACE TO THE THIRD EDITION. The call for a third edition of this work within two years of its appearance is a gratifying proof of its need and an indication of its favorable reception by the medical students of the country. The knowledge that the book has not altogether failed in its mission has incited an effort to make it more than ever a useful guide to the study of the Practice of Medicine, and as the result of a careful revision some im- portant modifications and additions will be found in the present edition. The author desires to express his gratitude for the many friendly criticisms which he has received from both public and private sources. 320 South 16th Street, Philadelphia, August, 1894. CONTENTS. Diseases of the Digestive System. General Symptomatology— The Teeth..........17 The Tongue.....!.'.'.' 17 Fetor of the Breath........18 The Appetite.........19 Dysphagia..........19 Yomiting, or Emesis...... . 19 The Vomit..........20 Acidity of the Gastric Contents......20 Hiccough..........21 Abdominal Pain and Tenderness.....21 The Stools..........22 Abdominal Distention........23 Diseases of the Mouth, Tonsils, Pharynx, and Oesophagus— Stomatitis..........23 Tonsillitis..........26 Hypertrophy of the Tonsils......28 Pharyngitis . . ........29 Spasm of the (Esophagus.......32 Organic Oesophageal Obstruction.....32 Diseases of the Stomach— Acute Gastritis.........33 Dyspepsia..........34 Atonic Dyspepsia........3.j Nervous Dyspepsia........35 (v) VI CONTENTS. Catarrhal Dyspepsia Gastralgia..... Gastric Ulcer .... Gastric Cancer .... Pyloric Obstruction and Dilatation of Haematemesis .... Diseases of the Intestines and Peritoneum Constipation..... Intestinal Colic .... Diarrhoea ..... Intestinal Catarrh Entero-colitis .... Dysentery ..... Cholera Morbus .... Cholera Infantum Typhlitis and Appendicitis . Intestinal Obstruction ; Ileus Animal Parasitic Affections Peritonitis..... Ascites ...... Diseases of the Pancreas- Pancreatic Apoplexy . Acute Pancreatitis Cirrhosis of the Pancreas . Pancreatic Calculi Cancer of the Pancreas Diseases of the Liver— Area of Liver Dulness Palpation of the Liver Percussion of the Liver Jaundice, or Icterus Icterus Neonatorum Acholia ..... Catarrhal Jaundice Biliary Calculi .... Hyperemia of the Liver Cirrhosis of the Liver . Abscess of the Liver . CONTENTS. vii PAGE Cancer of the Liver ........ 81 Amyloid Liver ......... 82 Hydatid Cysts of the Liver.......83 Acute Yellow Atrophy of the Liver.....84 Diseases of the Kidneys. General Symptomatology— The Urine..........85 Polyuria..........£5 Urea...........85 Lithuria..........86 Urates...........87 Leucin and Tyrosin........87 Phosphates. . ........88 Chlorides..........89 Oxaluria..........89 Urobilinuria.........90 Glucosuria, or Glycosuria . ...... 90 Albuminuria.........92 Acetonuria......... .93 Diaceturia and Oxybuturia......93 Haematuria.........93 Hemoglobinuria........94 Indicanuria.........94 Bile...........94 Chyluria..........94 Pyuria..........95 Diseases of the Kidneys, and Pelvis of the Kidney— Renal Hypersemia........95 Uraemia..........96 Acute Nephritis.........97 Chronic Parenchymatous Nephritis.....99 Chronic Interstitial Nephritis......100 Amyloid Kidney........102 Renal Calculus.........103 Pyelitis . ........105 viii CONTENTS. PAGE Hydronephrosis.........106 Floating Kidney........107 Diseases of the Blood. General Symptomatology— The Blood..........109 Oligocythaemia.........109 Leucocytosis ......... 109 Poikilocytosis.........109 Microcytosis and Macrocytosis ...... 110 Diminished Haemoglobin...... 110 Melanaemia.........110 Lipaemia......... HI Microoganisms in the Blood......Ill Anaemia, Scurvy, Addison's Disease, Purpura Haemorrhagica, and Haemophilia— Anaemia..........Ill Symptomatic Anaemia.......Ill Essential, or Primary Anaemia......112 Pernicious Anaemia........112 Chlorosis..........113 Leucocythaemia......... 114 Pseudo-leucaemia........115 Addison's Disease........115 Haemophilia.........116 Scurvy ..... ..... 117 Purpura Haemorrhagica.......117 Diseases of the Circulatory System. General Symptomatology— The Apex-beat.........119 Displacement of the Apex-beat......120 Changes in the Force and Extent of the Apex-beat . .120 Abnormal Centres of Pulsation.....121 Jugular Pulsation........122 Praecordial Prominence.......122 CONTENTS. ix PAGE Palpation.......... 122 Percussion..........122 Auscultation......... 123 The Intensity of the Heart-sounds.....123 Reduplication of the Heart-sounds . . . . . 124 Adventitious Sounds, or Murmurs.....124 Haemic Murmurs........124 Pericardial Friction-sounds......125 The Aneurismal Murmur, or Bruit.....125 The Pulse..........125 Palpitation.........128 Dropsy . . .'.......129 General Cyanosis ........ 129 Diseases of the Pericardium— Pericarditis..........130 Hydro-pericardium........133 Haemo-pericardium........133 Pneumo-pericardium........133 Diseases of the Heart— Endocarditis.........133 Chronic Valvular Affections......135 Aortic Stenosis, or Aortic Obstruction .... 135 Aortic Insufficiency, or Aortic Regurgitation . . . 136 Mitral Stenosis, or Mitral Obstruction .... 136 Mitral Insufficiency, or Mitral Regurgitation . . . 137 Tricuspid Stenosis, or Tricuspid Obstruction . . . 138 Tricuspid Insufficiency, or Tricuspid Regurgitation . 138 Pulmonary Stenosis, or Pulmonary Obstruction . . 138 Pulmonary Insufficiency, or Pulmonary Regurgitation . 138 Acute Ulcerative Endocarditis......141 Acute Myocarditis........142 Fibroid Heart.........142 Hypertrophy of the Heart.......143 Dilatation of the Heart.......144 Fatty Infiltration of the Heart......145 Fatty Degeneration of the Heart.....146 Angina Pectoris.......«. 147 X CONTENTS. PAGE Diseases of the Arteries— Aneurism of the Aorta.......148 Thoracic Aneurism........149 Aneurism of the Abdominal Aorta ..... 151 Arterio-sclerosis........151 Diseases of the Respiratory System. General Symptomatology— The Red Nose.........153 Flattening of the Bridge of the Nose .... 153 Movement of the Alae Nasi during Respiration . . 153 Nasal Discharge.........153 The Sense of Smell........153 Epistaxis..........154 Spasm of the Laryngeal Adductors ..... 154 Aphonia, or Loss of Yoice ...... 154 Paralysis of the Laryngeal Muscles.....155 Dyspnoea..........155 Number of Respirations per Minute . . . . . 156 Cheyne-Stokes, or Tidal-wave Breathing .... 156 Cough..........156 Expectoration.........157 The Microscopy of Sputum......158 Inspection of the Chest.......161 Phthisinoid Chest........161 Rachitic Chest.........161 Emphysematous Chest.......161 Local Prominences and Depressions ..... 162 Expansion..........163 Palpation....... . 163 Percussion.....*.'... 164 Auscultation.........165 ' Mensuration.........169 Diseases of the Nose and Larynx— Coryza..........170 Chronic Nasal Catarrh ....... 171 Acute Catarrhal Laryngitis ...... 173 CONTENTS. X] PAGE Chronic Laryngitis........174 Spasmodic Croup........176 Membranous Croup........177 Laryngismus Stridulus . .....179 Oedema of the Larynx.......181 Diseases of the Lungs— Bronchitis..........182 Dilatation of the Bronchial Tubes.....189 Asthma..........191 Hay Asthma.........194 Pulmonary Emphysema.......195 Haemoptysis.........198 Pulmonar}* Apoplexy........199 Congestion of the Lungs . .....200 Croupous Pneumonia........202 Catarrhal Pneumonia........ 207 Chronic Interstitial Pneumonia......211 Gangrene of the Lung.......212 Abscess of the Lung........213 QEdema of the Lungs.......214 Pulmonary Collapse....... 215 Pulmonary Tuberculosis.......216 Diseases of the Pleura— Pleurisy .......... 223 Hydrothorax.........227 Pneumothorax.........227 Haemothorax.........229 Acute Infectious Diseases. Fever .....•••••• 230 Period of Incubation........233 Date at which Rashes Appear......233 Protection from Future Attacks.....234 Periodic Remissions or Intermissions in the Fever . . 234 Fevers Associated with Jaundice.....235 Termination by Crisis.......235 Subnormal Temperature.......235 xii CONTENTS. Simple Continued Fever Typhoid Fever . Typhus Fever Relapsing Fever Cerebro-spinal Fever Malarial Fever . Scarlet Fever Measles Rotheln Smallpox Yaricella Yaccinia Erysipelas Yellow Fever Acute General Tuberculosis Diphtheria . Whooping-cough Influenza Mumps Cholera Tetanus Dengue Hydrophobia Constitutional Diseases. Rheumatic Fever Chronic Rheumatism . Muscular Rheumatism Gout .... Rheumatoid Arthritis Rickets Lithaemia . Diabetes Diabetes Insipidus CONTENTS. xiii Diseases of the Nervous System. Disturbances of Motion. PAGE Paralysis......... 310 Irregular Paralysis ........ 310 Monoplegia.........311 Hemiplegia.........311 Paraplegia..........312 Convulsions.........313 Epileptiform Convulsions....... 313 Tetanic Convulsions........314 Hysteroidal Convulsions.......314 Local Convulsions ........ 315 Saltatory Spasm.........315 Salaam Convulsions........315 Choreiform Movements....... 315 Athetosis..........316 Tremors..........317 The Gait.......... 317 The Reflexes...... . 318 Paradoxical Contraction.......320 Disturbances of Sensation. Anaesthesia.........320 Hemianaesthesia........320 Monanaesthesia.........321 Paranaesthesia.........321 Hyperaesthesia.........322 Paraesthesia.........322 Neuralgia..........322 Muscular Sensibility........322 Muscular Sense.........322 Disturbances of Nutrition. Muscular Atrophy........323 Reaction of Degeneration.......323 xiv CONTENTS. PAGE Arthropathies.........324 Myxcedema . . . ".......324 Ulceration Resulting from Perverted Nutrition . . 325 Disturbances of Consciousness. Coma...........325 Trance..........327 Somnambulism.........327 Ecstasy..........327 Catalepsy..........327 Disturbances of the Special Senses. The Eye..........327 The Ear..........328 Psychical Disturbances. Delusion..........328 Illusion..........329 Hallucination.........329 Imperative Conception.......329 Morbid Impulse.........329 Delirium..........329 Diseases of the Brain, Cord, Nerves, and Muscles. Tuberculous Meningitis.......331 Simple Leptomeningitis.......333 Chronic Pachymeningitis.......333 Hemorrhagic Pachymeningitis......334 Hydrocephalus.........334 Paretic Dementia........336 Cerebral Paralysis of Children......338 Cerebral Hyperaemia........339 Cerebral Anaemia........340 Cerebral Hemorrhage.......341 Obstruction of the Cerebral Arteries .... 345 Cerebral Softening........346 CONTENTS. XV PAGE Morbid Growths in the Brain......347 Abscess of the Brain....... 350 Cretinism....... 351 Spinal Leptomeningitis..... 352 Chronic Spinal Pachymeningitis.....353 Acute Myelitis....... 354 Chronic Myelitis...... 35g Sclerosis of the Spinal Cord..... 357 Locomotor Ataxia..... 357 Primary Spastic Paraplegia......360 Amyotrophic Lateral Sclerosis......361 . Ataxic Paraplegia....... 361 Disseminated Cerebro-spinal Sclerosis . . . .361 Hereditary^ Ataxia........362 Syringo-myelia.........363 Acute Anterior Poliomyelitis......363 Progressive Muscular Atrophy......365 Bulbar Paralysis........367 Acute Ascending Paralysis.......367 Caisson Disease.........368 Idiopathic Muscular Atrophy......369 Pseudo-hypertrophic Paralysis . . • . . . . 370 Neuralgia..........371 Migraine..........374 Headache..........375 Neuritis..........379 Multiple Neuritis........381 Sciatica..........382 Facial Paralysis.........383 Epilepsy..........385 Aphasia..........387 Vertigo..........389 Meniere's Disease........390 Hysteria..........391 Neurasthenia.........395 Chorea...........396 Paralysis Agitans........398 Artisan's Cramp.........400 xvi CONTENTS. PAGE Tetany..........400 Thomsen's Disease........401 Exophthalmic Goitre........402 Raynaud's Disease........403 Acute Angio-neurotic OEdema......404 Myxoedema..........404 Facial Hemi-atrophy........405 Acromegalia.........405 Sunstroke..........406 Intoxications— Alcoholism..........408 Opium-poisoning........410 Chronic Lead-poisoning.......Ill Chronic Mercurial Poisoning......412 Chronic Arsenical Poisoning......413 Diseases of the Skin and its Appendages. General Symptomatology— The Color of the Skin.......414 Hardness, or Induration of the Skin.....415 OEdema, or Dropsy of the Subcutaneous Tissues . . 416 Glossy Skin..........416 Enlargement of the Superficial Veins.....416 Cutaneous Emphysema.......416 Abnormal Conditions of the Nails.....417 Cutaneous Eruptions— Macules..........417 Purpuric Spots.........418 Vesicles..........420 Blebs, or Bullae.........422 Pustules..........422 Papules..........424 Tubercles..........425 Wheals, or Pomphi........426 Crusts......... . 426 Scales..........." 427 . Ulcers...........428 CONTENTS. xvil PAGE Diseases of the Sweat-glands— Anidrosis........■ # 430 Hyperidrosis.........430 Bromidrosis.......■ 431 Chromidrosis.........431 Sudamen..........431 Functional Diseases of the Sebaceous Glands— Seborrhoea..........432 Comedo..........433 Milium..........434 Steatoma..........435 Inflammatory Diseases of the Skin— Erythema Simplex........435 Erythema Intertrigo........436 Erythema Nodosum........436 Erythema Multiforme.......436 Urticaria..........437 Herpes Simplex.........438 Herpes Zoster.........439 Herpes Iris..........440 Acne Vulgaris.........440 Acne Rosacea.........442 Furunculus..........443 Carbunculus.........444 Psoriasis..........444 Eczema..........446 Lichen Ruber and Lichen Planus.....449 Prurigo..........450 Dermatitis Herpetiformis.......450 Dermatitis..........451 Ecthyma..........453 Pemphigus..........454 Impetigo..........455 Impetigo Contagiosa........456 Miliaria..........457 Atrophic Affections of the Skin- Albinism ..........458 B xviii CONTENTS. PAGE Vitiligo..........458 Atrophic Affections of the Hair and Nails . . • 459 Hypertrophic Affections of the Skin— Lentigo..........464 Chloasma..........464 Keratosis Pilaris.........465 Molluscum Epitheliale.......466 Callositas..........466 Clavus......... . .467 Cornu Cutaneum . .......468 Verruca..........468 Naevus..........469 Ichthyosis..........469 Hypertrophic Affections of the Hair and Nails . . 470 Scleroderma.........470 Morphcea..........471 Elephantiasis.........471 Dermatolysis.........472 New Growths of the Skin— Keloid...........473 Fibroma..........473 Angioma..........474 Xanthoma..........474 Lupus Erythematosa........475 Lupus Vulgaris.........476 Syphilis Cutanea........478 Leprosy..........480 Epithelioma.........482 Ainhum..........483 Neuroses of the Skin— Dermatalgia.........483 Pruritus..........484 Parasitic Affections of the Skin— Tinea Tricophytina........485 Tinea Versicolor........487 Tinea Favosa.........488 Scabies..........488 Pediculosis..........489 DISEASES OF THE DIGESTIVE SYSTEM. THE TEETH AND GUMS. Delayed dentition, and the eruption of badly-formed teeth, often result from rickets or congenital syphilis. Caries of the teeth results from many conditions; notably, an unnatural softness of the teeth, lack of cleanliness, dys- pepsia, the use of certain drugs, and diabetes. Hutchinson's teeth.—The lateral incisors of the upper jaw are pegged, and the central incisors of the same jaw have convex sides, and crescentic notches on their cutting edges. These peculiarities indicate hereditary syphilis, and are noted only in the permanent teeth. A blue line on the gums near the insertion of the teeth usually indicates chronic lead poisoning. Copper and silver poisoning occasionally produce similar lines. Spongy, bleeding gums are often associated with scurvy. Swelling of the gums with tenderness and salivation is indica- tive of mercurial poisoning (ptyalisni). THE TONGUE. Fur on the tongue.—This consists for the most part of ac- cumulated epithelial cells, particles of food, and microorgan- isms, and results from an elevation of temperature or from disturbed innervation. 2 18 DISEASES OF THE DIGESTIVE SYSTEM. A light, uniform coat is often noted in health, particularly in those who sleep with the mouth open. Other causal condi- tions are:— * (1) Febrile diseases. (2) Dyspepsia. (3) Catarrhal conditions of the nose and throat. Circumscribed furring often indicates local disturbance, as a jagged tooth or tonsillitis. Unilateral furring may result from disturbed innervation, as in conditions affecting the second and third branches of the fifth nerve. It has been noted in neuralgia of those branches, and in fractures of the skull involving the foramen rotundum. The dry, brown, and fissured tongue is noted in low fevers, as typhoid fever, typhoid pneumonia, typhoid dysentery. A red, beefy tongue is noted in certain febrile diseases, as typhoid fever and scarlet fever, and in diabetes. The " strawberry tongue" is characterized by a white fur, through which project bright red and prominent papillae. It is seen in the early stage of scarlet fever. A gray-coated and flabby tongue, with an oval bare spot in the centre, which is red and glossy, is sometimes seen in chil- dren, and is indicative of gastro-intestinal catarrh, or "mucous disease." (Starr.) Tremor of the Tongue. Trembling of the tongue is noted in many conditions; it is peculiarly marked in low fevers (typhoid), in alcoholism, and in paretic dementia. Scars on the Tongue. Scars on the tongue often result from syphilitic lesions, or from the tooth wounds of epilepsy. FETOR OF THE BREATH. This is often due to local inflammation, as chronic rhinitis, tonsillitis, etc.; to the retention of decomposing food, to caries VOMITING, OR EMESIS. 19 of the teeth; to certain lung diseases, especially gangrene and bronchiectasis, to dyspepsia, and to the ingestion of certain foods or drugs. THE APPETITE. Boulimia, or inordinate appetite, is a common symptom in nervous dyspepsia, diabetes, worms, and in certain insanities, notably in paretic dementia. Anorexia, or loss of appetite, is a symptom common to many conditions. Pica is a craving for unnatural articles of food, and is noted particularly in chlorosis, insanity, pregnancy, and worms. DYSPHAGIA. Dysphagia, or difficult swallowing, may result from: (1) Local inflammations. (2) Stricture of the oesophagus, spas- modic or organic. (3) Paralysis, local, as in diphtheritic paralysis; or centric, as in bulbar disease. VOMITING, OR EMESIS. Etiology.—(1) Toxic, from ptomaines, drugs, uraemia, and the specific fevers. (2) Centric disease, as cerebral tumors and meningitis; this type is often unaccompanied with nausea, and does not relieve the associated headache. (3) Diseases of the stomach, as ulcer, cancer, dilatation, dys- pepsia, etc. (4) Reflex, as from pregnancy, uterine or ovarian disease, irritation of the fauces, worms, biliary colic, etc. (5) Intestinal obstruction, this is often fecal. (6) Disturbed cere- bral circulation, as in swinging and sea-sickness. (7) Certain nervous affections, as hysteria, migraine. (8) Periodic vomit- ing may be in itself a neurosis, or may be associated with the gastric crises of locomotor ataxia. (9) Oesophageal vomiting results from obstruction, and the vomit is alkaline in reaction. 20 DISEASES OF THE DIGESTIVE SYSTEM. THE VOMIT. Watery, or mucous vomit, is noted in chronic gastritis, in certain forms of nervous dyspepsia, and after persistent emesis, as in cholera. Bilious, or green vomit, is not diagnostic of any special con- dition ; it may occur in any case where vomiting and straining are continued. Bloody vomit (Hcvmatemesis).—For cause, see page 45. When present in large amount, it can usually be recognized by the unaided eye; small amounts may be detected by the microscope, spectroscope, or by chemical tests. Test for blood.—Evaporate some of the filtered coffee-grounds vomit in a watch-glass, scrape off some of the dried material; add a trace of finely-pulverized salt; place the mixture on an object-glass, and cover. Allow one or two drops of glacial acetic acid to run under, and again evaporate; when dry allow one or two drops of distilled water to flow under to dissolve the crystals of salt. Under the microscope minute brown rhombic crystals of hsematin appear. Purulent vomit may result from the rupture of an abscess into the oesophagus or stomach, or from phlegmonous gastritis. Fecal vomit (stercoraceous) is indicative of intestinal obstruc- tion. Profuse vomit.—The ejection of large quantities of frothy fermented material is highly significant of gastric dilatation. Vomiting without nausea, distress, or other phenomena occurs in certain neuroses of the stomach, in hysteria^ uraemia, and in brain disease, as tumor, or as a precursor of apoplexy. ACIDITY OF THE GASTRIC CONTENTS. Normal acidity is due to lactic and hydrochloric acids, but other acids are frequently formed during the digestive process, such as butyric and acetic acids. For chemical examination, the vomit should be preserved and filtered, or, which is far better, the contents of the stomach should be drawn off after a test-meal and filtered. ABDOMINAL PAIN AND TENDERNESS. 21 Tests for free hydrochloric acid.—(1) Paper stained with a solu- tion of congo red turns blue. Not very reliable. (2) Paper stained with an alcoholic solution of oo-tropaeolin turns from a yellowish-brown to deep brown or red. (3) Giinzburg's test, very reliable. $. Phloroglucin, 2 parts; Vanillin, 1 part; Absolute alcohol, 30 parts. Add one or two drops to a similar quantity of the filtrate con- tained in a porcelain dish, heat gently, and if free hydrochloric acid is present a rose-red color develops. Hyperacidity.—This condition is especially noted in ulcer of the stomach, and in certain forms of nervous dyspepsia. Subacidity or inaeidity occurs: (l)In certain nervous affec- tions, as in some forms of nervous dyspepsia, hysteria, and neurasthenia. (2) In extreme anaemia. (3) In gastric catarrh. (4) In gastric cancer. (5) In most febrile diseases. (6) Often in passive congestion of the stomach. HICCOUGH. Hiccough, or singultus, results from a clonic spasm of the diaphragm, and is often noted as a temporary condition after eating or drinking. Persistent hiccough is sometimes present in extreme exhaustion following acute or chronic diseases. It results from irritation of the phrenic nerve, as from the pres- sure of a thoracic aneurism. It may be reflex from stomachic, hepatic, intestinal, or peritoneal disease. It may be due to hysteria. ABDOMINAL PAIN AND TENDERNESS. Diffuse abdominal tenderness is noted in peritonitis, in hys- teria, and in rheumatism of the abdominal muscles. Persistent abdominal pain results from the various visceral diseases chronic peritonitis, abdominal aneurism, and disease of the spinal vertebrae. Colic is a painful spasm of a mucous canal. The common varieties are—biliary, intestinal, renal, uterine, and pancreatic. 22 DISEASES OF THE DIGESTIVE SYSTEM. Painful defecation results from constipation, anal fissure, dysentery, piles, ulceration, stricture, prolapse of the rectum, and inflammatory conditions of neighboring organs, as the uterus or prostate gland. THE STOOLS. Blood in the Stools (Fntrorrhagia or Melcena). The blood is nearly normal in appearance after profuse hemorrhages, or when it has been quickly discharged, as in piles and fissure. Retained blood imparts a black or tarry appearance to the stools. Melaena results from: (1) Traumatism. (2) Acute in- flammation of the bowels, as in enteritis and dysentery. (3) Obstructed circulation, as in chronic heart and liver disease. (4) Vicarious menstruation. (5) Blood dyscrasia, as in scurvy, purpura, infectious fevers, etc. (6) Rupture of an aneurism. (7) Ulcers in the intestines, as simple duodenal ulcer, typhoid, dysenteric, tubercular, or malignant ulcers. (8) Intussuscep- tion. (9) The passage of blood from the stomach in haema- temesis. (10) Piles, fissure, fistula. Watery, or serous stools are noted in choleraic diseases, in nervous diarrhoea, in the colliquative diarrhoea which termi- nates wasting diseases, in severe enteritis, and in corrosive poisoning, as by arsenic, antimony. Green stools may result from an excessive amount of bile. They are also common in the diarrhoeas of young children, and in these cases the green color may be due to bacterial growth. (Hay em.) Black stools may follow intestinal hemorrhage, and the use of certain drugs, as charcoal, bismuth, iron, tannin, etc. Red stools usually indicate blood, but they may be tinged red after the administration of hematoxylin (logwood). 3hicous stools are noted in intestinal catarrh, particularly when the lower bowel is affected, as in entero-colitis and dys- entery. Fatty stools result from the ingestion of large quantities of fats, from the absence of bile, and from chronic pancreatic diseases. STOMATITIS. 23 Purulent stools result from fistula in ano, dysenteric, syphi- litic, or malignant ulceration, or the rupture of abscesses into the bowel, as prostatic and pelvic abscesses. Licnteric stools.—Stools which contain much undigested food are noted in inflammatory conditions of the stomach and upper bowel. ABDOMINAL DISTENTION. Causes.—(1) Enlargement of the various organs from tumors or other causes. Recognized by the history, irregular enlargement, and special symptoms referable to the organ af- fected. (2) Ascites. Recognized by movable dulness with superincumbent tympany, and fluctuation. (3) Tympanites. Recognized by universal tympany on percussion. (4) Preg- nancy. Recognized by suppression of menses, morning emesis, pigmentation of mammary areola, softening of the cervix, in- termittent uterine contractions, etc. (5) Distention of the bladder. Recognized by the history, location of dulness, and results of catheterization. STOMATITIS. Definition.—Inflammation of the mouth. Etiology.—(1) Mechanical, chemical, thermal, or parasitic irritation. (2) Mercurial poisoning. (3) Cachectic states, as in phthisis, cancer, and diabetes. (4) It is most commonly seen in young children in association with gastro-intestinal disturbances, brought about by artificial feeding, warm weather, and bad hygienic surroundings. Varieties.—(1) Catarrhal. (2) Aphthous. (3) Ulcerative. (4) Parasitic (thrush). (5) Gangrenous. (6) Mercurial. General Symptoms.—Heat and pain in the mouth, in- creased flow of saliva, fetor of the breath, restlessness, languor, disinclination to nurse, and perhaps some fever. Catarrhal Stomatitis (Simple stomatitis). Symptoms.—General symptoms of stomatitis, and, on in- spection, a diffuse red swelling of the mucous membrane. Treatment.—Good hygienic conditions. Keep the mouth 24 diseases of the digestive system. clean. Employ a weak solution of boric acid or of chlorate of potassium as a wash. Aphthous Stomatitis {Follicular stomatitis, Vesicular stom- atitis). Symptoms.—General symptoms of stomatitis, and, on in- spection, numerous small, round vesicles on the cheeks, lips, and tongue; these vesicles soon break, and leave little, shallow ulcers with a red areola. Prognosis.—Good. Treatment.—Sterilize the milk. Nurse at regular inter- vals. Wash the mouth with a clean linen cloth. Correct any gastric disturbance. Use locally :— 1^ Acid, boric, gr. x-xx; Glycerini, 13 ss; Aqua:, q. s. ad fgij.—M. Chlorate of potassium (gr. xx-xxx) may be substituted for the boric acid. Ulcerative Stomatitis.—This is thought by some to be an infectious disease, because it often occurs in epidemics, and attacks both children and adults when congregated and sub- jected to bad hygienic conditions. Symptoms.—General symptoms of stomatitis. Inspection.—The gums of the lower jaw are chiefly affected. They are swollen, red, and spongy. Linear ulcers, with gray, sloughing bases soon form, and may extend to the cheek. The glands under the jaw are swollen. In severe cases loosening of the teeth and necrosis of the bone may follow. Prognosis.—Guardedly favorable. Treatment.—Correct the hygiene. Tonic doses of quinine by the stomach or rectum are indicated. Touch the ulcers with nitrate of silver, apd use as a mouth-wash a solution of chlorate of potassium or peroxide of hydrogen. Parasitic (Thrush, Muguet). Exciting Cause.—Saccharomyces albicans. Symptoms.—General symptoms of stomatitis, and, on in- spection, numerous milk-white elevations which, on removal, leave a raw surface. The disease may extend to the pharynx, oesophagus, and larynx. Microscopic examination reveals the fungus. stomatitis. 25 Prognosis.—Good. Treatment.—Correct the hygiene. Treat any gastric dis- turbance. Tonics are often indicated. Locally, borax is of value, and may be used in the following mixture:— J£. Sodii borat., 3j ; Glycerini, fjij ; Aquse, f^vj.—M. Sig.—Apply several times daily by means of a camel's-hair brush. Gangrenous Stomatitis (Cancrum oris, Noma).—This form is usually seen in debilitated children between the ages of two and six years, and usually follows one of the specific fevers, especially measles and whooping-cough. Symptoms. — The general symptoms of stomatitis are marked. Inspection.—The cheek is the part affected. Externally, it is swollen, hard, red, and glazed; internally, there is noted an irregular, sloughing ulcer. Complications.—-Perforation, septicaemia, lobular pneu- monia from aspirated sloughs, and diarrhoea from the swal- lowing of fetid material. Prognosis.—Grave. Death is common from exhaustion or complications. Recovery is often attended with deformity. Treatment.—Good hygiene, alcoholic stimulants, nutri- tious food, tonics like iron and quinine. Locally.—Evert the cheek and apply the actual cautery, or pack the surrounding parts with oiled lint, apply to the ulcer strong nitric acid, and subsequently neutralize with bicarbo- nate of sodium. As a mouth-wash, peroxide of hydrogen is of extreme value. DIercurial Stomatitis (Ptyalism).—This form of stomatitis is seen in artisans who work in mercury, after the administra- tion of very large doses of mercurials, and after the adminis- tration of small doses when there has been an unnatural susceptibility. Symptoms. Premonitory Symptoms.—Tenderness of the gums, manifested by bringing the teeth forcibly together; redness of the gums near the insertion of the teeth, a metallic taste, and an increase of saliva. 26 diseases of the digestive system. Later Symptoms.—Profuse salivation, fetor of breath, red- ness, swelling, and tenderness of the gums. The tongue may be similarly affected and protrude from the mouth. In severe cases ulceration of the mucous membrane, loss of 'teeth, and necrosis of the jaw result. Treatment. — Use astringent mouth-washes. Employ iodide of potassium in small doses to eliminate the mercury. Opium may be required at night to allay distress. Belladonna aids in arresting the secretion. TONSILLITIS. (Amygdalitis.) Etiology.—Tonsillitis occurs at all ages, but it is particu- larly common in the young. The rheumatic diathesis exerts a predisposing influence. Exposure to cold and wet usually excites it, and such exposure is very effective when the system is debilitated, or the throat is congested from improper use of the voice. Impure air, as the effluvium from foul drains or sewers, sometimes excites it. Varieties.—(1) Simple, or catarrhal. (2) Follicular, or lacunar. (3) Phlegmonous (quinsy). Symptoms.—Pain in the throat increased by swallowing and talking; marked tenderness beneath the angles of the jaw; and fever with its associated phenomena; in severe forms the temperature is quite high, 104° or 105°. In the catarrhal form the tonsils are uniformly swollen, red, and covered with tenacious mucus. In the follicular form the tonsils are red and swollen, and present little yellow spots on their surfaces. These spots are found to be plugs of degenerated epithelium which are retained in the crypts on account of the swelling and occlusion of their outlets. These plugs are often expectorated during convales- cence as offensive cheesy pellets. In the phlegmonous form the tonsils are extremely swollen, often so much that they almost meet; the pain is intense and of a throbbing character. One gland soon becomes larger than the other, softens, fluctuates, and turns yellow from sup- puration. Swallowing is almost impossible, the voice is lost, and breathing is difficult. TONSILLITIS. 27 Diagnosis.—In children tonsillitis may resemble scarlet fever, especially when the former is associated with an acci- dental rash. Scarlet Fever.—History of contagion, onset with vomiting, a punctated red rash, " strawberry" tongue, albuminuria, and pulse too rapid to be proportionate to the fever. Diphtheria.—The follicular form resembles diphtheria, but in the latter there is a false membrane, not only on the tonsils but on surrounding parts, and its removal leaves behind a raw surface. The history of contagion, the rapid, weak pulse, the marked swelling of the submaxillary glands, albuminuria, and the Klebs-Loffler bacillus, detected by cultivation, will also indicate diphtheria. Prognosis.—Favorable ; even in grave cases rupture of the abscess occurs when death seems imminent. Suffocation from rupture during sleep, and death from ulceration of the carotid artery are extremely rare terminations. Treatment.—Rest, light diet, and protection. In the beginning, salicylate of sodium (gr. xx thrice daily) may be given to shorten the attack. The ammoniated tincture of guaiacum (3ij every two hours) is a very efficient remedy. The benzoate of sodium is also highly recommended :— J$_ Sodii benzoat., 3j-£iv ; Glycerin., Elix. calisay., aa, fgj.—M. Sig.—A teaspoonful every hour or two. In some cases quinine (gr. v. thrice daily) with small doses of the tincture of aconite and the tincture of belladonna is an efficient remedy. In severe cases opium is often required to relieve pain and to produce sleep. Local Treatment (Tnternal).—Pellets of ice give much relief. The following remedies are efficient: Solutions of nitrate of silver, dry bicarbonate of sodium, guaiac lozenges (gr. ij), saturated ethereal solution of iodoform. Or:— I£ Potass, chlor., gr. xx-xxx; Tinct. ferri chlor., Glycerin., aa f|ss ; Aqu:e, q. s. ad f^ij.—M. Sig,—Apply several times daily with a camel's-hair brush. 28 DISEASES OF THE DIGESTIVE SYSTEM. When the glands are very much swollen scarification will lessen the pain and often shorten the attack. When fluctua- tion is detected the tonsil should be incised with a guarded bistoury. External Applications.—An ice-bag, a poultice, or iodine. HYPERTROPHY OF THE TONSILS. Etiology.—Childhood, the rachitic and tubercular dia- theses, and repeated attacks of acute tonsillitis are the predis- posing causes. It may arise without obvious cause. Pathology.—It may be a true hypertrophy, but in most instances either the glandular structure or the connective tissue predominates; and the firmness of the gland increases in proportion to the overgrowth of the latter. The follicles are often dilated, and filled with cheesy material which results from the accumulation of fatty-degenerated epithelium. Naso- pharyngeal catarrh and adenoid growths in the naso-pharynx are often associated conditions. Symptoms.—Difficult swallowing, mouth-breathing, snor- ing during sleep, a thick voice with a nasal twang to it, and malnutrition. "Sufferers are very prone to acute attacks of catarrh of the nose and throat. In severe cases, from inter- ference with breathing, the chest assumes the rachitic type— that is, flattened at the sides and base and prominent over the sternum. Prognosis.—Favorable under prolonged and careful treat- ment. Treatment. General Treatment.—Build up the tone of the patient by frequent bathing with salt water, followed by fric- tion, light gymnastics, deep breathing, and by the use of nutrient tonics such as cod-liver oil, hypophosphites, and iodide of iron. L,ocal Treatment.—A solution of nitrate of silver, or LugoPs solution (liquor iodi compositus), may be applied frequently to the tonsils; or dilute acetic acid (gtt. ij) or a dilute solution of iodine (gtt. ij) may be injected into the tonsils. When the glands are very large they should be removed by the tonsil- lotome, scissors, or galvano-cautery. Pharyngeal adenoids PHARYNGITIS. 29 should likewise be removed by the finger-nail or curette while the patient is under the influence of some general anaes- thetic, or after the parts have been treated with cocaine. PHARYNGITIS. Acute Pharyngitis (Acute " sore throat," Simple angina). Definition.—An acute catarrhal inflammation of the mucous membrane of the pharynx, soft palate, and uvula, and frequently associated with tonsillitis and laryngitis. Etiology.—Exposure to cold and wet, especially when the system is debilitated or the throat is congested from improper use of the voice. It may be rheumatic in origin. It may be excited by local irritants, such as hot drinks or the inhalation of noxious gases. Exposure to infectious fevers, like scarlatina and measles, may be followed by simple pharyngitis. Symptoms.—Chilliness and slight fever with its associated phenomena; soreness in the throat, painful deglutition, a sen- sation of dryness or tickling, with a hacking cough ; stiffness and tenderness of the muscles of the neck. Extension to the larynx may cause hoarseness; to the ear, through the Eusta- chian tube, deafness. Inspection reveals a red and swollen mucous membrane. Varieties.—(1) Simple; recognized by the above symp- toms. (2) Rheumatic ; recognized by the history, intense pain, and stiffness of the muscles, without much change in the local appearance. (3) Follicular; the mucous membrane is red, swpllen, and covered with whitish spots which represent re- tained secretion in the inflamed follicles. (4) Infectious pharyn- gitis is the form associated with the infectious fevers. Prognosis.—Favorable. Treatment.—Light diet and avoidance of exposure. Hot drinks, followed by Dover's powder (gr. x), and a saline purge will sometimes abort it. Tincture of aconite (gtt. ij) with tincture of belladonna (gtt. v) every two hours is sometimes useful. In the rheumatic form the salicylate or benzoate of sodium is very efficient. 30 DISEASES OF THE DIGESTIVE SYSTEM. In simple angina Pepper recommends :— fy Potass, chlorat., giss-ij ; Potass, bromid., §ss; Ext. belladonnas, gr. iij-v ; Syr. limonis, f.^j ; Syrupi, q. s. ad f^iv.—M. Sig.—Teaspoonful thrice daily. Local Remedies.—A steam spray, pellets of ice, a gargle of chlorate of potassium (gr. x to f'3j), the application of a solution of nitrate of silver (gr. v to f SJ), or lozenges of cocaine, chloride of ammonium, or chlorate of potassium. Chronic Pharyngitis. Etiology.—Chronic "sore throat" usually results from re- peated acute attacks, improper use of the voice, or the con- tinuous action of irritants, like tobacco smoke. Varieties.—(1) Hypertrophic. (2) Atrophic. (3) Ulcer- ative. (4) Phlegmonous. Symptoms.—The voice is husky and its use is followed by distress ; secretion is increased so that there is a constant desire to clear the throat; disagreeable sensations, as fulness, tickling, and the like, are frequently noted. In the hypertrophic form (granular sore throat, clergyman's sore throat, chronic follicular pharyngitis) the mucous mem- brane is thick, swollen, traversed by dilated veins, and studded with numerous elevations which are composed of dis- tended follicles and overgrown lymphatic tissue. In the atrophic form (Pharyngitis Sicca), the mucous mem- brane is pale, smooth, glossy, and dry. Ulcerative Pharyngitis.—Ulceration may be due to simple inflammation, syphilis, tuberculosis, cancer, and lupus. Phlegmonous Pharyngitis (Retropharyngeal abscess).—Sup- purative inflammation of the retropharyngeal connective tissue may occur as a sequel to one of the infectious fevers, or may be due to caries of the cervical vertebrae, or to the impaction of a foreign body. It may be recognized by sore throat, weak voice, difficult deglutition, and the results of a digital examination. Treatment.—Chronic pharyngitis does not result so much stenosis of the ossophagus. 31 from excessive use of the voice as from its improper use, and until this is corrected no treatment will be successful. Pa- tients should be instructed to expel sounds by the aid of the diaphragm and abdominal muscles, instead of the muscles of the throat and larynx. The habit of hawking and scraping to clear the throat must be rigidly interdicted. The patient must guard against mouth-breathing. Sponging the neck night and morning, first with tepid, then with cold water, will render the throat less sensitive. The general health will re- quire attention, and such tonics as iron, quinine, strychnine may be very useful. Local treatment.—The naso-pharynx should be kept clean by frequent spraying or douching with some antiseptic solu- tion like the following :— I£ Sodii bicarb., Sodii biborat., aa gr. xx ; Acid, carbolic, gtt. vj ; Glycerin., fgvj ; Aquae, q. s. ad f^vj.—M. (Dobell.) The nasal chambers should be inspected and any existing disease treated. Astringent applications are often useful; solutions of nitrate of silver, five or ten per cent., sulphate of zinc, or tannic acid, ten to twenty per cent., may be employed for this pur- pose. Lymphatic hypertrophies should be removed by the galvano-cautery. Retropharyngeal abscesses will require evacuation and treat- ment directed to the cause. Ulcerative pharyngitis will require appropriate constitu- tional treatment, and such local remedies as nitrate of silver, iodoform, nitric acid, etc. STENOSIS OF THE OESOPHAGUS. Varieties.—(1) Functional obstruction, due to spasm (oesophagismus). (2) Organic obstruction. 32 DISEASES OF THE DIGESTIVE SYSTEM. SPASM OF THE OESOPHAGUS. Etiology.—Female sex ; nervous temperament; hysteria; reflex irritation. It may occur as a symptom of hydrophobia, tetanus, and organic oesophageal obstruction. Symptoms of Simple GEsophageal Spasm.—Paroxysmal dysphagia, often associated with a sense of constriction in the chest; little or no loss of flesh. An oesophageal bougie can be passed without much difficulty. Diagnosis.—The age and sex of the patient, the parox- ysmal character of the obstruction, the ability to pass a bougie, the absence of wasting, and the absence of any other cause, will serve to separate it from organic obstruction. Prognosis.—Good for life, but indefinite as regards dura- tion. Treatment.—Search for some exciting cause and remove it when possible. The treatment is largely dietetic, hygienic, and moral. Tonics like iron, arsenic, and quinine are often indicated, and may be combined with such antispasmodics as valerian, asafoetida, or sumbul. The systematic passage of a bougie may be of great value. A mild electrical current may be applied through the bougie. ORGANIC OESOPHAGEAL OBSTRUCTION. Etiology.—(1) An external tumor pressing on the oesoph- agus. This is most commonly an aneurism. (2) A tumor growing from the oesophageal wall; generally a cancer. (3) A cicatrix, from ulceration. The ulcer may be due to syph- ilis or to some corrosive poison, as a strong acid or alkali. (4) A foreign body. Symptoms.—A slowly increasing difficulty in deglutition, with the regurgitation of food. The oesophagus is often much dilated above the constriction, and the food may collect in the pouch thus formed, so that regurgitation may be delayed for several hours. The passage of a bougie meets with a perma- nent obstruction. There is much loss of flesh. Diagnosis.—The history of syphilis or corrosive poisoning will suggest a cicatrix. Aneurismal obstruction can usually ACUTE gastritis. 33 be detected by physical examination. Aneurism should be excluded before a bougie is passed. The age, cachexia, pain, and involvement of other organs will indicate cancer. Prognosis.—Depends on the cause. It is unfavorable in aneurism and cancer. In cicatricial contraction the obstruc- tion may be overcome for an indefinite period. Treatment.—Aneurism : Prolonged rest, restricted diet, and potassium iodide. Cicatricial contraction: Systematic dil- atation with graduated bougies. Cancer: In the early sta^e, the cautious use of a bougie is advisable. In advanced cases the patient may be fed through a tube, and when this is no longer possible, life may be prolonged for a short time by rectal alimentation or by feeding through a gastric fistula. ACUTE GASTRITIS. (Acute Gastric Catarrh.) Etiology.—(1) Ingestion of indigestible food, especially when followed by exposure to cold and wet. (2) Toxic sub- stances in excess, as alcohol, strong acids, and alkalies. (3) It is an associated condition in certain infectious diseases, as yel- low fever, measles, and scarlet fever. Pathology.—The mucous membrane is red, swollen, and covered with thick mucus. It is sometimes the seat of ecchy- moses. Symptoms.—The symptoms vary much in degree. In se- vere cases there may be moderate fever (102°-l03°) and its asso- ciated phenomena, with anorexia, coated tongue, intense pain in the epigastrium, which is tender to the touch, persistent vomiting, thirst, and considerable prostration. Jaundice may follow from the extension of the catarrh to the bile-ducts, and diarrhoea from its extension to the intestines. Diagnosis.—It may resemble the onset of scarlet fever, but the history of contagion, the " strawberry tongue," sore throat, very rapid pulse, and eruption, characterize the latter. Prognosis.—Usually favorable; it rarely lasts more than a few days. Treatment.-—Absolute rest. If the stomach has not been completely emptied, an emetic such as ipecac may be employed. 34 diseases of the digestive system. Locally, a mustard plaster or a turpentine stupe will aid in relieving the distress. In severe cases no food should be given by the mouth until the stomach becomes retentive. Thirst should be allayed with cracked ice. Later, milk with lime-water (a teaspoonful of each) may be given hourly, and this may be followed by light broths in similar quantities. Persistent vomiting may be relieved by small doses of calo- mel (gr. jl-A, bismuth (gr. v.-x.), carbolic acid (gtt. 5-J), or wine of ipecac (gtt. 1). I£ Hydrarg. chlor. mitis, gr. j ; Bismuth, subnit., gj.—M. Ft. in chart. No. xij. Sig.—One every hour. Or, ]£. Creosoti, gtt. iij ; Bismuth, subnit., gj.—M. Ft. in chart. No. xij. Sig.—One every hour. Or, $. Vin. ipecac, Tinct. nucis vom., aa fgj.—M. (Pepper.) Sig.—Two drops in water every two hours. Severe pain and obstinate vomiting will often yield to opium, in the form of suppositories. Thus :— fy Pulv. opii, gr. vj ; 01. theobrom., q. s.—M. Ft. in suppos. No. vj. Sig. —One every three hours. Toxic gastritis will require in addition appropriate anti- dotes. DYSPEPSIA. Definition.—The word dyspepsia means ill digestion, and is applied to a group of symptoms which accompanies every disease of the stomach ; when, however, the symptoms depend on nothing more than simple atony, hypersensitiveness, or chronic catarrh, the patient is said to have dyspepsia. Corresponding to these conditions, three varieties have dyspepsia. 35 been recognized, viz.: (1) Atonic. (2) Nervous, and (3) Catarrhal dyspepsia. Etiology.—(1) Heredity. (2) All visceral diseases, as heart, liver, and kidney disease. (2) Overwork, mental or physical. (4) Gastric irritants, as tea, coffee, and alcohol in excess. (5) Dietetic errors, which include—insufficient mas- tication from bad teeth or hurried eating, too much food, in- sufficient food, coarse or improperly cooked food, excessive dilution of food with liquids, excess of condiments, and irreg- ular eating. Symptoms of Dyspepsia.—Coated tongue, perverted ap- petite, fulness and distress after eating, eructations, flatulence, " heart-burn," palpitation, headache, vertigo, disturbed sleep, and lassitude. ATONIC DYSPEPSIA. Characteristic Symptoms.—The tongue is pale, coated, flabby, and tooth-marked ; the appetite is lost; there is a sense of fulness and distress over the stomach, some time after eating, without actual pain or tenderness. The bowels are constipated. There is much flatulence. The patient is pale, the muscles are soft, the pulse is weak, and there is great lassitude. Prognosis.—Good. Treatment.—The diet must be carefully regulated, and rich and heavy food rigidly interdicted. The hygienic sur- roundings must be so modified that the general condition of the patient will be improved. Tonics like iron, quinine, and strychnine are often indicated. Dilute mineral acids with pepsin will be required to assist the digestive process. Purgatives should be avoided, and constipation relieved by diet, mineral waters, enemas, or suppositories. NERVOUS DYSPEPSIA. This type usually occurs in those of a distinctly nervous temperament, and excessive mental strain and dietetic errors are potent etiological factors. 36 DISEASES OF THE DIGESTIVE SYSTEM. Characteristic Symptoms.—The tongue is often clean. The appetite is very irregular—at one time it is lost; at an- other it is inordinate; at another it is perverted, the patient craving an unnatural diet. Severe pain is a prominent symp- tom which is apt to appear when the stomach is empty, and to be relieved by eating. The term gastralgia is applied to this pain. Vomiting is not common, but it may occur when the stomach is full or empty. The gastric acidity may be normal or subnormal, but it is often excessive. Other nervous phenomena are commonly present, such as headache, vertigo, disturbed sleep, hypochondriasis, neuralgia, palpitation, and perverted sensations. Diagnosis.—The history, associated nervous phenomena, the time that the pain appears, the periods of complete relief, the absence of hemorrhage, cachexia, tumor, and local tender- ness, are the chief diagnostic points. Prognosis.—Good, when the cause can be removed and the patient thoroughly controlled. Treatment.—The avoidance of excitement and excessive mental work must be enjoined. An extended voyage may effect a cure. In brain-workers the value of regular physical exercise and frequent bathing, followed by friction of the skin, cannot be overestimated. On the other hand, the anaemic and exhausted may require the " rest-cure." -The patient's experi- ence will assist in the regulation of the diet. Tonics like iron, arsenic, quinine, and strychnine are often indicated. Elec- tricity applied to the stomach has given good results. Pepsin and mineral acids will be of service only in those cases in which examination reveals a lack of acid in the gastric juice. In such cases Dr. Pepper recommends :— $. Quininse sulph., gr. xxxij ; Strychninae sulph., gr. ss ; Acid, hydrochlor. dil., fgij. vel Acid, phosphor, dil., fgiij ; TV. cardamom, comp., f^ij ; Aquae, q. s. ad f§iv.—M. Filter. Sig.—Teaspoonful after meals. CATARRHAL DYSPEPSIA. 37 CATARRHAL DYSPEPSIA. (Chronic Gastritis, Chronic Gastric Catarrh.) Catarrh of the stomach is often a primary condition result- ing from the ordinary causes of dyspepsia, but its frequent dependence on disturbed circulation from heart, lung, and liver disease should never be forgotten. Pathology.—In the early stages the mucous membrane is ashy-gray in color and covered with tenacious mucus. Ecchymoses are often noted. Microscopic examination re- veals degeneration of the glandular epithelium and an over- growth of the connective tissue. In advanced cases the walls may be thin from extreme atrophy of the glandular structure, but more often they are thick, wrinkled, and indurated from excessive overgrowth of connective tissue. Characteristic Symptoms.—The tongue is irregularly coated, the tip often red, and the papillae enlarged. The ap- petite is variable. After eating there is weight and distress, and often diffuse tenderness on palpation. There are fre- quent eructations of wind and sour liquid. Nausea and vomiting are frequently present; the latter may occur in the morning on rising, and the ejected material be composed of the frothy mucus which has collected in the stomach during the night, or it may occur some time after eating, and be composed of partially-digested food mixed with acids of fermentation, such as lactic, butyric, and acetic acids. The normal acid, hydrochloric, is invariably diminished or absent. The bowels are constipated, and the urine is scanty and throws down a heavy deposit of urates or phosphates. The nervous phenomena common to all forms of dyspepsia are present. Protracted cases, with atrophy of the gastric tubules, present the symptoms of pernicious anaemia. Diagnosis. Cancer.—After forty, haematemesis, cachexia, tumor, the short duration, and the involvement of other organs. Ulcer.—Haematemesis, sharp pain increased by eating, vomit- ing soon after eating, local tenderness, abundance of hydro- chloric acid. 38 DISEASES OF THE DIGESTIVE SYSTEM. Care must be taken to determine whether the catarrh is primary or secondary to visceral disease. Prognosis.—When not dependent on organic disease of other viscera, the prognosis is good. Treatment.—Good hygienic conditions. A regulated diet; in severe cases an absolute skimmed-milk diet, or par- tially-digested foods. Thick mucus and undigested food may be removed by the stomach-tube when its introduction is well borne. Pure or slightly alkaline water may be employed; but when there is much fermentation, one per cent, of salicylic acid may be added with advantage. Irrigation should be practised daily, or every other day, preferably before break- fast, and the tube should be kept in position until the escap- ing fluid is quite clear. When lavage is not well borne, the patient may be directed to sip before breakfast a half pint of some hot alkaline water, such as Carlsbad. This is especially indicated when there is constipation. Artificial Carlsbad salt:— I£ Sodii sulph., ^v ; Sodii bicarb., gij '■> Sodii chlorid., 3j.— M. (Welch.) Sig.—gj in a half pint of water half hour before breakfast. Dilute hydrochloric acid is nearly always indicated, and it may be combined advantageously with pepsin. $. Tinct. nucis vom., f.^ss ; Acid, hydrochlor. dil., fgij ; Pepsin., giij ; Aquae, q. s. ad. f^iv.—M. Sig.—A teaspoonful after meals. The catarrhal process is often favorably influenced by sub- nitrate of bismuth, or nitrate of silver. When there is much fermentation and flatulence, salicylate of bismuth (gr. v-x), or subnitrate of bismuth with some antiferment may be employed. ^ Salol, gr. xl; Bismuth, subnitrat., gss.—M. Ft. in chart. No. xx. Sig.—One powder half an hour before meals. GASTRALGIA. 39 Instead of salol, creosote (gtt f) may be added to each powder. Constipation should be relieved by diet, mineral waters, enemas, suppositories of glycerin or gluten, or by mild laxa- tives. Acid eructations and " heart-burn" may be relieved by digestants and dilute acids, taken immediately after meals; or by alkalies, with or without such antiferments as creosote, salol, or naphthol, taken one or two hours after meals. GASTRALGIA. (Gastrodynia, Neuralgia of the Stomach.) Definition.—A painful paroxysmal affection of the stomach, unassociated with any organic lesion. Etiology.—Nervous temperament, overwork, anaemia, and dietetic errors are the predisposing causes. Symptoms.—Paroxysms of severe pain in the epigastrium, usually radiating to the back, occurring when the stomach is empty, and relieved by pressure and the ingestion of food or warm stimulating drinks. Diagnosis. Gastric Ulcer.—In this disease the pain is more continuous, is made worse by eating, and is often associated with local tenderness and haematemesis. Cancer.—-The age, history, continuous pain which is in- creased by eating, haematemesis, tumor, cachexia, anorexia, and absence of hydrochloric acid will separate cancer from gastralgia. Angina Pectoris.—The radiation of the pain from the heart down the arm, fixation of the body, fear of impending death, and the associated symptoms of fatty heart, such as arcus senilis, rigid radials, and altered heart-sounds, will separate angina pectoris from gastralgia. The lancinating pains of locomotor ataxia sometimes attack the stomach and produce what are termed gastric crises. These can be distinguished from simple gastralgia by the absence of the patellar reflex, by the Argyll-Robertson pupil, the loss of coordination, and by paroxysmal pains in other parts of the body. Prognosis.—Favorable, but duration indefinite. 40 DISEASES OF THE DIGESTIVE SYSTEM. Treatment. Attach—Hot fomentations should be ap- plied locally, and Hoffmann's anodyne (3ss), chloroform (gtt. x), dilute hydrocyanic acid (gtt. ij in hot water), or the follow- ing mixture may be given internally :— $. Spt. vin. gal. Tinct. opii camph., aa f^ss ; 01. caryoph., gtt. x.—M. Sig.—A teaspoonful in hot water. In severe cases morphia will be required. The Interval.—Correct the hygiene, regulate the diet, and enjoin rest. Travel may be extremely valuable. Neuras- thenia may require the " rest-cure." Tonics are often indi- cated. When there is hyperacidity, salicylate of bismuth, carbonate of soda, or aromatic spirits of ammonia, after meals, may be very serviceable. Arsenic, valerian, and dilute hydro- cyanic acid are remedies of great value. $. Sodii arsenat., gr. ss; Ext. cannabis ind., gr. iij.—M. (DaCosta.) Ft. in pil. No. xx. Sig.—One, three times daily. GASTRIC ULCER. (Simple Ulcer, Perforating Ulcer.) Definition.—An ulcer arising without obvious exciting cause, but which is probably due to the digestive action of highly acid gastric juice on a part of the stomach whose nutri- tion has been impaired by some local disturbance of the cir- culation. Etiology.—Female sex, age (between the fifteenth and the fortieth year), overwork with poor food, and anaemia are the predisposing causes. Pathology.—From some local disturbance of the circula- tion—injury, hemorrhage, thrombosis, embolism, or spasm of the vessels—the part is self-digested. The ulcer is round or oval, usually situated at the pylorus, on the posterior wall, near the lesser curvature. It has a punched-out appearance, is conical in shape, with the apex towards the peritoneum, and is without an inflammatory areola. GASTRIC ULCER. 41 The floor of the ulcer is usually smooth, and may be formed by any one of the coats of the stomach. A series of ulcers is not uncommon, so that more than one may be detected. Symptoms.—The general symptoms of dyspepsia; loss of flesh and strength; and the following characteristic symp- toms : (1) Severe pain, increased by eating; it may radiate to the back ; it may be paroxysmal; it may be worse in certain positions. (2) Local tenderness. (3) Persistent vomiting after taking food ; the gastric juice is unnaturally acid. (4) Hemor- rhage is common; it varies in amount from a trace of blood to a quart or more. In some cases only the symptoms of dyspepsia are present, while in others all symptoms may be absent, and in the latter hemorrhage or perforation may be the first indication. Events.—(1) Resolution. (2) Death from exhaustion, hemorrhage, perforation and peritonitis, or pyloric obstruction from cicatricial contraction. Diagnosis. Cancer.—The age (after forty), history, down- ward course, short duration, extreme cachexia, often out of proportion to gastric symptoms, tumor, absence of hydro- chloric acid and blood less in amount and more disintegrated. Gastralgia.—The pain usually appears when the stomach is empty, and is relieved by food and pressure; no hemorrhage, no local tenderness; other nervous phenomena are commonly present. Chronic Gastritis.—Hemorrhage rare, tenderness diffuse, pain less marked, vomiting less frequent and persistent, gastric acidity less than normal. Prognosis.—Guardedly favorable; such complications as hemorrhage or perforation may occur without warning, and relapses from new ulcers are not uncommon. Treatment.—Absolute rest in bed and rectal feeding. Later, and in less severe cases from the beginning, pre- digested milk, milk and lime-water, buttermilk, broths, soft- boiled eggs and preparations of corn-starch may be given by the mouth at regular and frequent intervals. This restricted diet should be continued for eight or ten weeks, and the return to solid food should be quite gradual. The more complete the rest the more rapid will be the cure. Lavage is contraindi- 42 DISEASES OF THE DIGESTIVE SYSTEM. cated, but the stomach may be cleaned by the sipping of hot alkaline water in the morning before breakfast. Internally, subnitrate of bismuth and nitrate of silver are useful remedies. !£. Argenti nitratis, gr. v ; Ext. opii, gr. iij.—M. Ft. in pil. No. xx. Sig.—One pill thrice daily half au hour before meals. Or, $ Bismuth, subnitrat., gvj-gj ; Creosot., gtt. x; Morphin. sulph., gr. i-ij.—M. Ft. in chart. No. xx. Sig.—One powder before meals. Instead of morphia cocaine (gr. ^) may be added to each powder. When there is much pain counter-irritation will be of ser- vice. Hemorrhage will require absolute rest; morphia (gr. ^) and fluid extract of ergot hypodermically; an ice-bag to the stomach, and pellets of ice and tannic acid (gr. v—x) by the mouth. GASTRIC CANCER. Varieties.—(1) Hard cancer (scirrhus). (2) Soft cancer (medullary or encephaloid). (3) Epithelioma. (4) Colloid cancer. Etiology.—Male sex, age (after forty), heredity, and ulcer- ation of the stomach are predisposing causes. Pathology.—Cancer of the stomach is usually primary ; other organs being involved secondarily. The scirrhous form is the most common. As the pylorus is the usual seat, gastric dilatation is a natural sequence. Symptoms.—The general symptoms of dyspepsia, with the following characteristic symptoms: Continued pain, often tenderness; vomiting of partially-digested food; absence of free hydrochloric acid in the gastric juice (confirmatory only); haematemesis, the loss being usually slight, and the blood so altered by the gastric juice that it presents a " coffee-ground" appearance; presence of a tumor ; loss of flesh and strength ; ex- treme anaemia; involvement of the superficial lymph glands. DILATATION OF STOMACH. 43 When the pylorus is involved, symptoms of gastric dila- tation will be added. These are : Vomiting, after the lapse of several hours or days, of large quantities of fermented ma- terial rich in sarcinae ventriculi, increased area of gastric tym- pany on percussion, and a reversed peristaltic wave on inspec- tion. Diagnosis.—The differential diagnosis of gastric cancer from ulcer, gastralgia, and chronic gastritis has already been discussed. Prognosis.—Absolutely fatal. The duration is from six months to two years. Treatment. Palliative.—A liquid or semi-liquid diet. Rest. Hydrochloric acid and pepsin are often required to as- sist digestion. When the stomach is dilated lavage may give relief. Pain should be relieved by morphia. The other symptoms will require the treatment indicated in gastric ca- tarrh. At present, operative interference could scarcely be recommended. PYLORIC OBSTRUCTION AND DILATATION OF THE STOMACH. Etiology.—The causes of pyloric obstruction: (1) Pyloric tumors, usually malignant. (2) Tumors of adjacent viscera pressing on the pylorus or duodenum. (3) Cicatrix of an ulcer. (4) Fibroid thickening from chronic catarrh. Pyloric obstruction increases the resistance offered to the expulsion of food, and in its efforts to overcome this, the stom- ach first becomes hypertrophied and then dilated. Causes of Dilatation of the Stomach (Gastrectasis).—(1) Py- loric obstruction. (2) Relaxation of the walls from simple atony or catarrh. (3) Excessive ingestion of food or drink. Symptoms.—The general symptoms of dyspepsia, with the following characteristic symptoms, most of which relate to the vomit: Vomiting occurs long after eating, sometimes sev- eral hours or days; the amount is often excessive, sometimes several quarts; it is sour and fermented, and on standing sep- arates into a sediment of undigested food and a supernatant 44 DISEASES OF THE DIGESTIVE SYSTEM. liquid, which is turbid and frothy; the ejected material is rich in torulae and sarcinae ventriculi. There is obstinate constipa- tion. Fig. l. a. Sarcina ventriculi. b. Torula cerevisise. Physical Signs. Inspection.—Bulging over the epigas- trium ; in thin subjects the outline of the stomach may be visible. Sometimes a peristaltic wave is detected. Palpation.—A splashing fremitus. Percussion.—Increased area of gastric tympany. Artificial distention of the stomach with carbonic-acid gas, evolved by the administration of bicarbonate of soda and tartaric acid, is rarely necessary, and is sometimes harmful. Auscultation.—Splashing sounds. These are often audible at some distance, and hence are a frequent source of annoy- ance to the patient. Mensuration.—Normally an oesophageal sound may be in- serted a distance of 60 ctm. from the teeth ; in dilatation it may be inserted 65 or 70 ctm. Prognosis.—Depends on the cause; it should always be guarded. It is more favorable in dilatation without obstruc- tion. In cicatricial contraction operative interference has given fair results. In cancer the prognosis is absolutely unfavor- able. Treatment.—The diet should be light and nutritious, not bulky, and should be given in small amounts at frequent in- tervals. Lavage practised two or three times weekly is of great value. In cancer the treatment is palliative. In fibroid CONSTIPATION. 45 thickening and cicatricial constriction, dilatation of the pylorus (Loreta's operation) or the establishment of a gastro-duodenal fistula may be suggested. These operations have been fairly successful. In simple dilatation, treat the catarrh and apply massage and electricity; the latter may be applied to the in- terior of the stomach by means of a bipolar stomachal elec- trode. (Rockwell.) Tonics, especially strychnia, are often valuable adjuncts. An abdominal support often relieves some of the distressing symptoms. ILEMATEMESIS. (Gastrorrhagia.) Etiology.—(1) Traumatism. (2) Acute gastritis. (3) Obstruction to the circulation, as in chronic heart, lung, and liver disease. (4) Vicarious menstruation. (5) Blood'dys- crasia, as in scurvy, infectious fevers, grave anaemia, purpura, etc. (6) Rupture of an aneurism. (7) Gastric ulcer. (8) Gastric cancer. (9) Swallowing of blood from nose, mouth, or throat. (10) Hysteria. Diagnosis. Hematem'sis.—Blood is often clotted and mixed with food, is acid in reaction; the subsequent stools may be tarry, and the associated symptoms usually point to the stomach or adjacent organs. Hemoptysis.—Blood is red, frothy, and alkaline in reaction, the subsequent expectorations are streaked with blood, and physical signs usually indicate the cause. Treatment.—Absolute rest; abstinence from food by the mouth : an ice-bag to the stomach. Pellets of ice may be sucked. Tannic acid (gr. v-x) by the mouth, and fluid ex- tract of ergot (3ss) with morphia (gr. \) hypodermically. If the hemorrhage has been profuse, use subcutaneous injections of weak saline solutions; give iron by the mouth, and advise the use of salty broths. CONSTIPATION. Definition.—An unnatural detention of fecal matter. Etiology.—(1) Many acute and chronic diseases which lessen peristalsis and secretion, as most chronic visceral dis- 46 diseases of the digestive system. eases, all nervous diseases, anaemia, and the infectious fevers, except typhoid. (2) Sedentary habits. (3) Concentrated food. (4) Certain drugs, as lead and opium ; it is an after- effect of strong purgatives. (5) Atony of the intestinal wall, common in the old and debilitated. (6) Stricture. Symptoms.—Infrequent stools, dyspepsia, fetid breath, headache, vertigo, lassitude, anaemia. Results.—In aggravated cases : dyspepsia, diarrhoea from irritation, fecal accumulation, hemorrhoids, fissure, fistula, prolapse of the rectum. Treatment.—A regular time for defecation should be ob- served. Systematic exercise, abdominal massage, and elec- tricity are valuable aids. Encourage the use of water, bran- bread, green vegetables, and stewed fruits. In mild cases a glass of water or an orange before breakfast will suffice. Ene- mata of water, or glycerine (3j~3iv), or suppositories of glyc- erine or of gluten may be required. Mineral waters, like Friedrichshall or Hunyadi, often give relief. In obstinate cases mild laxatives must be employed ; cascara sagrada is one of the best. The dose of the extract is one to three grains ; of the fluid extract, half to a fluid drachm. Sometimes combinations are desirable. $. Aloin, gr. iv ; Styrchninae, gr. 3 ; Ext. belladonna?, Pulv. ipecac, aa gr.ij.—M. Ft. in pil. No. xx. Sig.—One or two as required. Or, ^l Pulv. rhei, gr. xl; Pulv. aloes, gr. xx ; Ext. physostig., gr. iij ; 01. caryophylli, gtt. iij.—M Ft. in pil. No. xx. Sig.—One or two as required. DIARRHCEA. 47 INTESTLNAL COLIC. (Enteralgia, Tormina.) Definition.—A painful spasmodic affection of the intes- tines. Etiology.—It usually results from irritating food, flatu- lence, or fecal accumulation. It is sometimes rheumatic. It may be reflex from ovarian or uterine disease. It is also a symptom of lead-poisoning, intestinal inflammation, and intes- tinal obstruction. Symptoms.—Paroxysms of severe pain of a twisting char- acter, centering around the umbilicus, and relieved by pressure. The abdomen is usually distended. Severe attacks may lead to incipient collapse, indicated by cold sweats, pinched features, feeble pulse, and vomiting. The attack lasts from a few minutes to several hours, and usually ends by a discharge of flatus. Diagnosis. Lead Colic.—History, blue line on the gums, retracted abdominal walls, and lead in the urine. Biliary Colic.—Pain radiating from the liver to the back and right shoulder, jaundice, and calculus in the stool. Renal Colic.—Pain radiating down the ureter to penis and testicle, blood, mucus, pus, or calculi, in the urine. Abdominal Aneurism.—Tumor, pulsation, bruit. Progn osis.—Favorable. Treatment.—Apply hot applications to abdomen, and administer morph. (gr. |) with sulphate of atropine (gr. y^To) hypodermically. Subsequently employ a saline or mercurial purge. Lead Colic.—Use sulphate of magnesium as a cathartic, and iodide of potassium (gr. v-x, thrice daily) to eliminate the lead. DIARRHCEA. Definition.—A condition in which the stools are too fre- quent or too liquid. Like dyspepsia, it is a symptom of many - pathological conditions. Etiology.—(1) It results from inflammation of the in- 48 DISEASES OF THE DIGESTIVE SYSTEM. testines, as enteritis, entero-colitis, dysentery. (Inflammatory diarrhoea.) (2) It is a symptom of certain infectious diseases, as typhoid fever, cholera. (Symptomatic diarrhoea.) (3) It is produced by certain drugs, as laxatives and purgatives. (4) It may be an expression of cachexia occurring as a final symptom in cancer, diabetes, and chronic Bright's disease. (Colliqua- tive diarrhoea.) (5) It may be a closing symptom in acute febrile diseases which end by crisis, as typhus fever, re- mittent fever. (Critical diarrhoea.) 6. It may result from nervous excitement or sensational disturbance. This is prob- ably due to a vaso-motor paresis of the intestinal vessels (an intestinal " blush"), and the subsequent outpouring of serum. (Nervous diarrhoea.) INTESTINAL CATARRH. (Diarrhoea, Catarrhal Enteritis.) Etiology.—Warm weather, childhood, and bad hygiene are general predisposing causes. It is usually excited by a sudden change in temperature, or by irritating products in the intestinal canal, as harsh food, ptomaines, or bacteria. It may be induced by corrosive poisons, as antimony, arsenic, mer- cury. Pathology.—The mucous membrane, especially of the upper bowel, is injected, swollen, and covered with tenacious mucus. The solitary and agminated glands are enlarged, and are sometimes the seat of pinhead ulcerations. In chronic enteritis the mucous membrane is often thickened from an overgrowth of connective tissue, but in some instances it is unusually thin from atrophy of the coats and destruction of the glands. Symptoms. Acute Enteritis.—Frequent stools, three to twelve or more a day; they are usually of a yellowish or greenish color, and frequently contain undigested food. Colicky pains, and rumbling noises (borborygmi), coated .tongue, anorexia, and sometimes slight fever. Chronic Enteritis.—Frequent liquid stools which vary in color and character according to the seat of catarrh ; much INTESTINAL catarrh. 49 undigested food (lientery) indicates involvement of the upper bowel; and niiich mucus, involvement of the lower bowel. The excessive drain leads to anaemia, emaciation, and weak- ness. Membranous Enteritis.—This term has been applied to two conditions : (1) A true croupous enteritis, which is associated with the formation of a false membrane, and which is seen in cachectic states, in acute infectious diseases, and as a result of mineral poisoning. (2) Mucous colic, or mucous colitis, a chronic form of colitis, usually occurring in women of a marked nervous temperament, and characterized by paroxysms of severe pain, and the discharge of gray translucent casts which, however, are not membranous, but mucoid in character. Diagnosis. Dysentery.—Bloody and mucous discharges, tenesmus, greater prostration. Entero-colitis.—Moderate fever, greater prostration, tender- ness along the colon ; stools contain mucus, blood, and ma- terial resembling chopped spinach. Prognosis.—Good, under favorable conditions. Treatment.—In adults.—Rest. Liquid diet. When there is retention of irritating material, indicated by the his- tory, sharp pain, abdominal distention, and small stools, ad- minister a laxative, as calomel, or castor oil with laudanum. I£. Hydrarg. chlor. mit., gr. ij ; Sodii bicarb., 3j.—M. Ft. in chart. No. xii. Sig.—One every hour until five or six have been taken. Or— fy. 01. ricini, Syr. rhei aromat., aa f^ss ; Tinct. opii, gtt. x-xx.—M. Kepeat, if necessary. When the bowel has been thoroughly emptied, opium, as- tringents, and intestinal antiseptics will be required. Thus :— fy Bismuth, subnit., gss ; Morphin. sulph., gr. j ; Creosoti, gtt. vj.—M. Ft. in chart. No. xii. Sig.—One every two hours. 4 50 DISEASES OF the digestive system. Or— ty. Bismuth, subnit., Cretae praepar., aa £ij ; Tinct. opii camph., f^iss ; Tinct. kino, fgij ; Pulv. acaciae, q.s ; Aquae cinnamomi, q.s. ad. f^vj.—M. Sig.—A tablespoonful every three hours. Chronic Diarrhoea.—Liquid diet. Rest. Intestinal antisep- tics (salicylate of bismuth, naphthalin, salol), and opium with mineral astringents. Diarrhoza in Children.—Absolute cleanliness. Frequent bathing. A change of air, if possible. If the child is bottle- fed, the milk must be sterilized and given at regular intervals. If the diarrhoea still persists, milk should be abandoned, and the child fed for a few days on egg albumin, beef juice, or beef peptonoids. A flannel binder should be applied to the abdomen. The bowels should be emptied with castor oil (3j) to which may be added a few drops of paregoric; or— I£ Hydrarg. chlor. mit., gr. j ; Bismuth, salicylat., gr. xxxvj ; Pulv. zingiber., gr. xij.—M. Ft. in chart. No. xii. Sig.—One every hour. After this has operated, astringents may be employed. I£ Sodii salicylat., gr. xij ; Bismuth, subnit., gr. xxxvi; Pulv. aromat., gr. vj.—M. Ft. in chart. No. xii. Sig.—One every two hours. ]£. Sodii bicarb., gss ; Syr. rhei aromat., f^ss; Aq. menth. pip., fgijss— M. (Starr.) Sig.—3j every two hours. Or— & Sodii salicylat., gr. xxiv; Bismuth, subnit., 3ij ; Tinct. opii camph., f'3iij; Mist, cretse, t'siss; Aquae cinnamomi, q.s. ad f^ii.j.—M. Sig.—One to two teaspoonfuls every two hours. ENTERO-COLITIS. 51 ENTERO-COLITIS. (Follicular Enteritis.) Definition.—An inflammation involving mainly the ileum and colon, and affecting especially the lymphatic glands. Etiology.—Warm weather, childhood, improper food, and bad hygiene are predisposing factors. It usually follows catarrhal enteritis or cholera infantum. Pathology.—The mucous membrane is red, swollen, and oedematous. The solitary and agminated glands are swollen and often ulcerated. Symptoms.—Frequent stools, at first yellow, later green, and mixed with curd, mucus, blood, and sometimes material resembling chopped spinach. The dejecta are neutral or acid in reaction. There is moderate fever (101°-102°), with its usual phenomena. The abdomen is distended, and tender along the colon. Vomiting is usually present. The child grows pale, wastes, and assumes a senile appearance. Death may be preceded by coma and convulsions. (Spurious hydro- cephalus.) Diagnosis.—Reference has already been made to its sepa- ration from catarrhal enteritis. Cholera infantum: Abrupt onset, very high fever, persist- ent serous vomiting and purging, and early collapse. Prognosis.—Grave, yet recoveries follow under favorable conditions. Treatment.—Much the same as in catarrhal enteritis. Stimulants are frequently required. Weak stupes or spice poultices should be applied to the abdomen. Topical treat- ment should not be neglected. The bowel should be irrigated once a dav with a pint or more of tepid water containing one per cent, of benzoate of soda or salicylic acid. The irrigation may be followed by the injection of an ounce of water con- taining nitrate of silver (gr.|--l). 52 diseases of the digestive system. DYSENTERY. (Bloody Flux.) Definition.—An inflammatory disease of the colon, char- acterized by tenesmus, and the passage of small, mucous, and blood-streaked stools. Etiology.—(1) Warm climates and warm weather; (2) bad hygience; (3) ingestion of irritating food ; (4) exposure to cold and wet; (5) cachectic states (scurvy, gangrenous stomatitis, and Bright's disease) are predisposiug factors, and alone may produce simple dysentery ; but the tropical form (also occurs in cold climates) seems to be excited by an animal parasite, the amoeba coli. The disease frequently occurs in epidemic form. Varieties.—(1) Acute catarrhal or sporadic dysentery. (2) Amoebic or tropical dysentery. (3) Malignant or diph- theritic dysentery. (4) Chronic dysentery. Pathology. Catarrhal Dysentery.—Mucous membrane of the colon is red, swollen, oedematous, and in some cases ulcer- ated. Fig. 2. Amoeba coli. Amoebic Dysentery.—The mucous membrane is swollen from oedema and cellular infiltration. The latter causes superficial necrosis, and the formation of irregular ulcers which more or less undermine the surrounding mucosa. The amoebae are found in the floor of the ulcers, and in the surrounding tissue. In some cases, false membrane and sloughs appear. Abscess of the liver is a common complication. Diphtheritic Dysentery.—The mucous membrane is intensely swollen, and covered with a false membrane, which results DYSENTERY. 53 from coagulation-necrosis. The separation of the membrane is followed by ulceration and sloughing. Chronic Dysentery.—May be simple or amoebic. The coats are greatly thickened and ulcers are usually found. Cicatri- cial contractions sometimes follow. Symptoms^ Acute Catarrhal Dysentery.—Moderate fever and its associated phenomena, prostration, colic, abdominal tenderness, tenesmus (fulness in the rectum with a constant desire to defecate) with small, mucous, and bloody stools. Amoebic Dysentery.—May begin as an acute or chronic dis- ease. The symptoms are similar to catarrhal dysentery, but the disease is more protracted, and often marked by intermis- sions and exacerbations; the stools are more fluid and contain the amoeba coli, and abscess of the liver is a more frequent complication than in other forms of dysentery. Malignant or Diphtheritic Dysentery. — To the ordinary symptoms the following typhoid phenomena are added : Mut- tering delirium, stupor, subsultus, carphologia, and a brown, fissured tongue. The stools also contain false membrane and sloughs. Chronic Dysentery.—Great loss of flesh and strength; ex- treme anaemia; the discharges contain considerable mucus and at times are bloody. Tenesmus and pain may be absent. The history of the initial symptoms will establish the diagnosis. Diagnosis. Diarrhoea. — Absence of tenesmus and of mucoid and bloody stools. Intussusception.—Late development of fever, stools more bloody than mucoid, the presence of a " sausage-like" tumor and persistent vomiting. Prognosis.—In acute catarrhal dysentery the prognosis is good; recovery usually follows in from a few days to a week. In amoebic dysentery the prognosis should be guardedly favorable; relapses are common, and abscess of the liver is liable to occur. The duration in favorable cases is from six to eight weeks. Malignant dysentery is always a grave dis- ease and often proves fatal. Complications.—Peritonitis from extension or perforation, hepatic abscess, stricture, and paralysis from neuritis. Treatment. Acute Dysentery.—Absolute rest and the en- forced use of the bed-pan. Liquid diet. Apply externally 54 DISEASES OF THE DIGESTIVE SYSTEM. hot fomentations, mustard-poultices or leeches. A mild laxa- tive is indicated in the beginning; sulphate of magnesia (3ij), or castor-oil and laudanum might be selected, and either may be repeated until the effect is produced. Internally, bismuth is a valuable remedy; salicylate of bis- muth (gr. x) or subnitrate of bismuth with salol or creosote may be employed. I£ Morphin. sulph., gr. j ; Bismuth, subnit., 31 j ; Creosoti, gtt. vj.—M. Ft. in pulv. No. xii. Sig.—One every hour or two. Or, £ Salol, 3J ; Bismuth, subnit., Sodii bicarb., aa gr. c—M. In twenty capsules. (Dujardin-Beaumetz.) Sig.—One three or four times daily. Musser recommends— I£ Quininae sulph., gr. xl; Ext. opii, gr. v ; Mass. hydrarg., gr. x.—M. Ft. in pil. No. xx. Sig.—One or two every two or three hours. In some cases, particularly in those associated with bilious symptoms, ipecacuanha, in large doses (gr. xx-xxx, repeated every three or four hours), is very serviceable. To prevent emesis, twenty drops of laudanum should be given half ai>hour before the administration of the ipecacuanha. Topical treat- ment should never be omitted. In mild cases opium supposi- tories will prove very beneficial; in severe cases enemata of thin starch-water with laudanum (gtt. xx-xxx) should be substituted for the suppositories. H. C. Wood highly recom- mends the use of ice suppositories, one every two to five minutes for half an hour, followed by suppositories of ergot and iodoform :— $. Ext. ergot., gr. lxxij ; Iodoform., gss; 01. theobrom., q. s.—M. Ft. in suppos. No. vi. Sig.—One every two hours until four or five have been taken. cholera morbus. 55 Astringent injections of nitrate of silver or lead acetate should be reserved for subacute or chronic cases. Injections of warm solutions of quinine (j^ to rT5L_) nave recently been employed in amoebic dysentery with advantage. (Osier.) Creolin (a drachm to the pint) has given good results in similar cases. In malignant dysentery, quinine, alcohol, and turpentine are indicated. Chronic Dysentery.—Rest; liquid diet; intestinal antisep- tics (salicylate of bismuth), and copious injections of nitrate of silver in aqueous solution, as recommended by Wood. Begin with one or two pints (gr. xx to the pint), and inject through a tube pushed far up the bowel; later, increase to three or four pints (gr. xxx to the pint). The injections may be em- ployed once or twice weekly. CHOLERA MORBUS. (English Cholera, Cholera Nostras.) Definition.—An acute, sporadic disease, resembling Asiatic cholera, but not excited by the comma bacillus of Koch. Etiology.—The summer season predisposes, and irritating food, as unripe fruit, and a sudden change of temperature are the usual exciting causes. A ptomaine or a special bacillus probably induces the disease. Symptoms.—Intense cramps in the stomach, vomiting and purging of bilious material, moderate fever, and great pros- tration. In severe cases the discharges become serous, and symptoms of collapse develop. Diagnosis. Asiatic Cholera.—The presence of an epidemic; not bilious, but rice-water discharges ; the detection of Koch's comma bacillus. Corrosive Poisons (as antimony).—History; the vomiting- precedes purging; burning pain in oesophagus and rectum; and bloody mucous discharges. Prognosis.—Favorable ; death rarely occurs. Duration, twenty-four to forty-eight hours. Treatment.—Hot applications to the abdomen. Morphia (gr. ^) with atropia (gr. jfa), hypodermically, repeated if 56 diseases of the digestive system. necessary. When the pain is less severe opium may be given by the mouth or rectum. Ice is soothing and relieves the thirst. When vomiting is the most troublesome symptom the following will be beneficial:— $. Morph. sulph., gr. j ; Creosoti, gtt. vj ; Bismuth, subnit., 31J.—M. Ft. in chart. No. xii. Sig.—One every hour. Prostration will require stimulants, like aromatic spirits of ammonia or brandy. In many cases the following mixture will be all that is required:— ty. Tinct. opii camph., f^ss ; Spt. amnion, aromat., f3J ; Magnesias, 3j; Aq. menth. piperitae, q. s. ad. f^iv.—M. (Hartshorne.) Sig.—A teaspoonful every twenty minutes. CHOLERA INFANTUM. Definition.—An acute disease of childhood, characterized by high fever, vomiting, purging, and collapse, and dependent upon an inflammation of the gastro-intestinal tract, and some disturbance of the sympathetic ganglia. Etiology.—Hot weather, faulty feeding, dentition, and bad hygiene are predisposing factors. Pathology.—The mucous membrane of the stomach and intestines is red, swollen, and oedematous ; the glands are en- larged or ulcerated. The profuse serous discharges and rapid collapse must be due, in part, to some disturbance of the sym- pathetic nerves. Symptoms.—The onset may be gradual or abrupt. Diar- rhoea is usually the initial symptom ; the stools are thin and serous, have a musty odor and an alkaline reaction. Vomit- ing soon develops, and the gastric irritability is so great that everything is rejected. Thirst is intense, the temperature is very high (105° to 108°); the pulse is rapid and feeble; the urine' is scanty. Collapse follows, and is indicated by the CHOLERA INFANTUM. 57 pinched features, hollow eyes, sunken fontanelles, and cold surface. Even at this time a reaction may set in, but more commonly death results from exhaustion. The end may be characterized by the symptoms of spurious hydrocephalus— restlessness, convulsions, irregular pupils, and coma; and as these phenomena are unassociated with any cerebral lesion they are probably toxaemic. Diagnosis. Entero-colitis.—Gradual onset, moderate fever, vomiting less marked, stools more mucous than serous and neutral or acid in reaction, pulse not so rapid, and no tendency to sudden collapse. Prognosis. — Grave. Under conditions most propitious, death may result in from one to three days; on the other hand, no aspect is too serious to admit of recovery. Entero- colitis is a common sequel. Treatment.—If possible, the child should be removed to the country or seashore. It should be kept in the open air. Cleanliness is essential to success, and frequent bathing with cool water is desirable. A spice-plaster or a weak stupe should be applied to the abdomen. The nourishment should consist of barley-water, beef-juice, wine-whey, chicken-broth, or frozen blocks of beef-tea; these should be given in small quantities at frequent intervals. Pellets of ice should be given to allay thirst. A few drops of brandy or of aromatic spirits of ammonia may be required at frequent intervals to combat prostration. To arrest vomiting use calomel (gr. ^), subnitrate of bismuth (gr. iij-v), or nitrate of silver. P£ Argenti nitrat., gr. ss-j ; Syr. acaciae, f,l j ; Aquae, fjij.—M. Sig.—A teaspoonful every two hours. For the diarrhoea, laudanum (gtt. ij-iij) with starch-water (3j) may be given every three or four hours by the rectum. Or the following may be given by the mouth :— !£. Liquor, morph. sulph., fgj ; Acid, sulphur, aromat., Ttl xxiv ; Elix. curacoae, fgss; Aquae, q. s. ad. fgiij.—M. gio- —One teaspoonful every two hours for a child six months old. 58 DISEASES OF THE DIGESTIVE SYSTEM. When vomiting and purging seem uncontrollable, morphia fer- rio" to ifo) hypodermically may be very useful. Irrigation of the stomach and bowel with warm water has been highly recommended, and though heroic sometimes gives brilliant results. In collapse, use a hot bath to which a little mustard or red pepper has been added; then place the child in a horizontal position, cover with warm blankets, and ad- minister stimulants freely. TYPHLITIS AND APPENDICITIS. Definition.—Inflammatory affections of the right iliac fossa have been divided into : (1) Typhlitis, an inflammation of the caecum. (2) Appendicitis, an inflammation of the ap- pendix. (3) Perityphlitis, an inflammation of the serous covering of the caecum. Etiology.—Typhlitis, or Ccecitis, is an uncommon disease, and usually results from traumatism or fecal impaction (Typh- litis stercoralis). Clinically it cannot be distinguished from appendicitis. Appendicitis is a common affection. Early life, male sex intestinal catarrh, ingestion of irritating food, constipation^ and previous attacks are predisposing factors. Foreign bodies or fecal accumulations in the appendix or traumatism usually excite it. Perityphlitis is always secondary to appendicitis. Pathology.—In grave cases the appendix is thickened, injected, ulcerated, or necrosed; and peritonitis or localized abscesses are frequently discovered. Symptoms.—It may begin gradually or abruptly. The usual manifestations are moderate fever (101°-104°) with its associated phenomena; severe pain in the right iliac fossa which is' increased by flexing and extending the thigh ; consti- pation, and, later, vomiting. Physical Signs.—The patient usually lies with the rio-ht thigh flexed. b Palpation elicits tenderness, and sometimes diffuse or cir- cumscribed induration. When the appendix is favorably INTESTINAL OBSTRUCTION. 59 situated, a finger in the rectum may detect fulness and indu- ration to the right. Percussion often yields a dull note. In some instances the first manifestation is general peri- tonitis. It should be borne in mind that abrupt general peritonitis without obvious cause is usually due to appendicitis. Complications.—(1) Peritonitis by extension or perfora- tion. (2) Abscess, pointing externally in the ileo-caecal region, in the flank or buttock ; or internally, exciting peritonitis. Prognosis.—Always guarded ; cases apparently mild may terminate fatally. Mild cases, in which the symptoms are probably due to typhlitis, often recover rapidly under appro- priate treatment. Treatment. — Absolute rest. Liquid diet. The lower bowel should be emptied by enemata. Opium should be given for the relief of pain. In the initial stage, salines cautiously administered may yield excellent results; Epsom salts (5ij) should be given every two hours until two or three watery stools have been produced. Local Treatment.—An ice-bag may be placed on the ileo- caecal region, but if there is much tenderness leeches followed by poultices give the most relief. Increasing tenderness and induration, a stable or rising tem- perature, persistent vomiting, obstinate constipation, or increas- ing abdominal tympany will each demand surgical interference. Patients subject to recurrent attacks should be scrupulously careful as regards hygiene and diet; they should be habitually clothed in flannel, and should wear an abdominal protector. Residence in a dry and equable climate sometimes secures im- munity. A formal operation for the removal of the appendix may be considered in these cases. INTESTINAL OBSTRUCTION; ILEUS. Etiology. Acute Obstruction.—(1) Congenital occlusion. (2) Intussusception (Invagination). (3) Strangulation, internal or external. (4) Twists (Volvulus) or Knots. The following are conditions which produce chronic obstruc- tion, though at times the symptoms develop acutely : (1) Stric- 60 DISEASES OF THE DIGESTIVE SYSTEM. ture from a healed ulcer. (2) Unnatural accumulations, as fecal masses (Coprostasis), foreign bodies, gall-stones. (3) Tumors, within or without. Symptoms. Acute Obstruction.—(1) Sudden pain, at first paroxysmal, but later continuous. (2) Constipation. (3) Vomiting, persistent, and becoming fecal (stercoraceous). (4) Abdominal distention. (5) Collapse, indicated by pinched features, cold extremities, and feeble pulse. Chronic Obstruction.—These symptoms devolop slowly. Congenital Occlusion.—The usual location is the anus or rectum. It is detected by direct examination. Intussusception.—The slipping of a portion of intestine into another portion immediately below it. It is noted chiefly in children, and is more common in males. Its exciting cause is probably perverted peristalsis, whereby one part of the bowel is contracted while the adjacent part is dilated. In rare in- stances it has been induced by the traction of intestinal polypi. The usual seat is the ileo-caecal region. Multiple invaginations are frequently found post-mortem, which have resulted from the irregular peristalsis occurring just before death ; they possess no inflammatory characteris- tics. In invaginations not cadaveric, the parts are injected, swollen, and covered with lymph. Diagnosis.—The symptoms of obstruction, with the age; a "sausage-shaped" tumor in the line of the colon ; the rare detection of the invaginated portion in the rectum ; tenesmus; and bloody mucous stools are the diagnostic features. Prognosis .— Death usually results from gangrene, peri- tonitis, or collapse. A favorable termination sometimes results from the escape of the incarcerated part, or by a sloughing off of the strangulated portion and adhesion of the serous surfaces. Strangulation.—This often occurs in external hernia, when it can be recognized by an examination of the inguinal, femoral, and umbilical rings. Internal Strangulation is due to the slipping of a coil of intestine through the diaphragm, foramen of Wmslow, an abnormal opening in the omentum or mesentery, or a loop of inflammatory lymph. INTESTINAL OBSTRUCTION. 61 Diagnosis.—It might be suspected by the absence of other cause, by the sudden onset, or by a history of previous peritonitis. Twist.—Occurs most commonly in middle-aged men. The usual seat is the sigmoid flexure. A relaxed and lengthened mesentery is a predisposing factor. Diagnosis.—Rarely possible. Stricture.—Usually results from syphilitic, tuberculous, or dysenteric ulcers. The rectum is the most common seat. Diagnosis. — History, gradual onset, results of rectal examination, and "pipe-stem" or "ribbon-like" stools are diagnostic features. Unnatural Accumulations—Fecal impaction is recognized by the gradual onset, mild obstructive symptoms, history of constipation, and a painless, irregular, doughy tumor in the line of the colon. Gall-stones may obstruct the ileum; the history will aid in their recognition. Tumors.—The most common tumor within the bowel is a cancer; it is usually located in the sigmoid flexure or rectum. Diagnosis.—Age, gradual onset, pain, bloody discharges, cachexia, and a tumor in the rectum are the characteristic features. Tumors pf adjacent viscera may compress the bowel. Their recognition will depend upon physical examination. Treatment.—In all cases of acute obstruction, excepting external hernia and congenital atresia, whether the cause is apparent or not, observe the following rules :— 1. Administer opium to relieve pain and check peristalsis. 2. Apply hot fomentations to the abdomen. 3. Restrict the diet to liquids in small quantities. Nutri- tive enemata should be employed in the weak. 4. Avoid purgatives. 5. Elevate the buttocks, insert a rectal tube, and distend the colon with from two to six quarts of tepid water, which should flow from a reservoir placed from ten to twenty feet above the patient. The age will determine the length of the tube and the amount of fluid. 6. When the stomach and upper bowel are distended by 62 diseases of the digestive system. gas, washing out of the stomach is useful. (Kiissmaul, Lieber- meister.) 7. After failure in these methods laparotomy should not be delayed ; the earlier its performance the greater the chance of success. In fecal impaction administer salines and inject water or oil. Electricity is sometimes useful. Rectal accumulations may be removed by the fingers or a suitable scoop. Strictures require surgical interference. ANIMAL PARASITIC AFFECTIONS. Tape-worms. Varieties. — Taenia solium. Taenia saginata. Bothrio- cephalus latus. Taenia echinococcus. History.—The eggs of the tape-worm are ingested by an animal, and embryos, or proscolices, are liberated in the stomach; these migrate to other organs, where they are transformed into larvae or scolices. The encysted larva, or scolex, is termed a cysticercus; the condition is known as " measles." The mature worm develops in man from the cysticercus contained in infected meat. Taenia Solium (Pork Tape-worm).—Is derived from the hog, and is two or three yards in length. The head is the size of that of a pin, is provided with four pigmented cup-like suckers, surrounded by a double row of hooklets, and is attached to the body by a thread-like neck. The sexual ori- fice is in the centre of the broad surface of the segment. Taenia Saginata (Taenia Mediocanellata).—Is derived from beef, and is five or six yards in length. The head is larger than that of the taenia solium, and has four large suckers, but no hooklets. The segments are fatter, and the uterine branches are finer and more numerous than in the taenia solium. Bothriocephalus LatUS.—Is found especially in Europe, and is derived from fish. The head has no hooklets, but two lateral grooves. The body is very long. The sexual orifice is on the narrow side of the segment. ANIMAL PARASITIC AFFECTIONS. 63 Symptoms.—Often absent. Frequently there are dyspeptic symptoms, colicky pains, loss of flesh, capricious appetite, and sometimes reflex nervous phenomena, such as vertigo, palpi- tation, " night-terrors," convulsions, itching in the nose, and choreic movements. The Diagnosis rests on the discovery of the eggs or seg- ments in the stools. Treatment.—A light diet for a day or two, and a saline purge prior to the administration of the anthelmintic. After an unsubstantial breakfast administer one of the following efficient remedies : Pumpkin seeds (two to three ounces) ; oleo- resin of male fern (3j-ij), pelletierine, the alkaloid of pome- granate (gr. v); Kooso (|ss). fy Oleoresin. aspidii, fgj ; Pulv. acaciae et sacchar., aa q. s. Aquae cinnamomi, q. s. ad f gij.—M. Sig.—One tablespoonful, repeated if required. A purge should be given a few hours after the vermifuge. The treatment is successful only when the head is passed. Nematodes. Ascaris Lumbricoides (Round Worms).—Life history un- known. They are of a pale-pink color, and in form resemble earth-worms. They inhabit the small intestines, but occa- sionally migrate into other organs, viz., stomach, bile-ducts, and larynx. They are most commonly found in children. Symptoms.—Often absent. Sometimes there are dyspepsia, mucous stools, colicky pains, voracious appetite, anaemia, and reflex nervous phenomena, as " night-terrors," grinding of the teeth, pruritus of nose and anus, choreic movements, and con- vulsions. Treatment—Santonin (gr. |—gr. iij); worm-seed oil (gtt. x in capsule or on sugar); fluid extract of spigelia (f3j-f3uj)j are efficient remedies. $. Santonini, gr. vj ; Hydrarg. chlor. mit., gr. vj ; Sacchari., gr. xxiv ; M. et ft. chart. Xo. xij. (Starr.) Sig.—One powder morning and evening. 64 diseases of the digestive system. Oxyuris Vermicularis (Seat-worm, Pin-worm).—This is a small worm, most commonly seen in children, and occupies the colon and rectum. It produces intense itching of the anus, which is worse at night. It may migrate into the vagina and excite pruritus or vaginitis, and lead to mastur- bation. Treatment.—An injection of water, followed by the in- jection of two or three ounces of an infusion of quassia chips (3ij-iij to the pint). Anchylostomum Duodenale.—A small worm, not uncom- mon in the north of Europe and Egypt. It has been detected most frequently in miners and brickmakers, who are probably infected by drinking water containing the eggs of the parasite. The worm inhabits the small intestine. Symptoms.—Dyspepsia and intense anaemia. The latter has been termed Egyptian chlorosis, and may be recognized by the detection of eggs in the stools. Treatment.—Santonin, male fern, and thymol have been recommended. Tricocephalus Dispar ( Whip-worm).—A small worm, thick at one end and thread-like at the other. It occupies the colon and caecum, and produces but little disturbance. Filaria Sanguinis Hominis. — A small thread-like worm, most commonly seen in the tropics. The adult occupies the lymphatics, and the female brings forth a great number of embryos, which soon find their way into the blood-current. It is noteworthy that they may be detected in the blood at night but not during the day. The medium of infection is probably the mosquito, which carries the embryo from the blood to the water. Symptoms. — Often absent. Chyluria, haematuria, and lymph-scrotum sometimes result from lymphatic obstruction. Trichina Spiralis.—A small worm derived from the hog. Man is infected by eating insufficiently-cooked pork contain- ing the encapsulated worm. The worm is set free in the stomach, where it develops and brings forth living embryos. These soon migrate into the muscles, where they in turn de- velop, coil themselves up, and become encapsulated. Trich- inous capsules, impregnated with lime-salts, are visible to PERITONITIS. 65 the naked eye, and are sometimes detected accidentally at autopsies. Symptoms of Trichinosis.—Sometimes absent. When large numbers have been ingested, gastro-intestinal symptoms develop in a few days. These are: Pain, nausea, vomiting, and serous diarrhoea. Muscular Symptoms.—In from one to two weeks muscular symptoms develop. The muscles become swollen, firm, ex- tremely tender and painful. Movement is inhibited, and dyspnoea results from the involvement of respiratory muscles. (Edema, especially of the face, is a prominent symptom. Pro- fuse sweating is sometimes observed, and high fever is com- monly present. Prognosis.—Depends on the number of worms ingested. The majority of patients recover. Treatment.—Prevent by thoroughly cooking all pork products. In the first stage use purgatives. After migration employ opium, warm fomentations, and stimulants. PERITONITIS. Definition.—Inflammation of the peritoneum. Varieties.—According to cause, it may be primary or secondary; according to extent, local or general; according to time, acute or chronic; and according to the exudate, sero- fibrinous, fibrinous, or purulent. Etiology. — Acute peritonitis may be: (1) Idiopathic, arising from exposure to cold and wet (rare). (2) Traumatic. (3) Perforative, resulting from a perforating wound, or the rupture of a gastric, typhlitic, typhoid, or dysenteric ulcer, or a visceral abscess. (4) Secondary to inflammatory disease of adjacent viscera, as septic endometritis and typhoid fever. (5) Secondary to some general morbid process, as rheumatism, Bright's disease. Pathology.—In the first stage the membrane is red, sticky, and lustreless; later, a sero-fibrinous, fibrinous, or puru- lent exudate is formed. In some cases the exudate is tinged with blood. 5 66 DISEASES OF THE DIGESTIVE SYSTEM. Symptoms. Acute General Peritonitis.—Chill; moderate fever (102°-103°), with its associated phenomena; a rapid, wiry pulse; abdominal pain and tenderness so intense that abdominal respiration and body movements are inhibited; the patient lies on his back with his thighs flexed ; the features are pinched; the vomiting is persistent; the bowels are con- stipated. Inspection reveals great abdominal distention. Palpation elicits tenderness, and rarely a friction fremitus. Percussion at first yields universal tympany; but later, dulness in the flanks from the gravitation of the exudate. Diagnosis. Acute Enteritis.—Pain and tenderness not so marked, absence of wiry pulse, and diarrhoea instead of con- stipation. Intestinal Obstruction.—Unless associated with peritonitis, there is no fever, no wiry pulse, nor extreme tenderness; the vomiting becomes fecal. Hysterical Abdomen.—This condition may resemble peri- tonitis in all particulars. The sex and personal history must be considered. Fever is not usually present, the pulse is not rapid and wiry; when the attention is distracted the pain may vanish. Prognosis.—Generally unfavorable. Death usually results in a few days from exhaustion. When the process is neither septic nor extensive recovery frequently follows. Treatment.—Restrict the diet. Administer opium in full doses to check peristalsis and relieve pain. In severe cases the drug may be pushed until the respiration has been reduced to twelve per minute; apply leeches to the abdomen, and fol- low with light poultices. In some cases cold cloths are more grateful than warm applications. In non-perforating cases, salines, as Epsom or Rochelle salts (3ij), may be given until bowels move freely. These salts, while not increasing peri- stalsis, attract serum from the turgid bloodvessels, and so relieve congestion. In perforating cases—and these are the most frequent—laparotomy offers the only hope of cure. ASCITES. 67 Chronic Peritonitis. . Etiology.—It is usually tuberculous; it mav be cancerous; it may be syphilitic (occurring in young children); it rarely follows Bright's disease it rarely follows an acute attack; it occurs in chronic alcoholism. Pathology.—The intestines are matted together by bands of fibrous lymph. The omentum is often contracted and greatly thickened. Effusion is usually present, but it varies greatly in amount; in the tuberculous and cancerous varieties it may be bloody. Symptoms.—Fever is often absent. Pain is not severe, and is commonly paroxysmal. There is usually diffuse tenderness. Inspection.—The abdomen is generally distended; often irregularly, from sacculated effusions, inflated intestinal coils, or the projecting matted omentum. Palpation may detect a friction fremitus, and the irregulari- ties noted above. The resistance is often great. Percuss ion.-- Dulness in the flanks with superincumbent tympany. When the fluid is sacculated, the dulness may be irregularly distributed. Fluctuation can sometimes be elicited. Prog nosis.—Unfavorable. Treatment.—Rest. Light diet and nutrient tonics (malt, cod-liver oil). Iodide of potassium is given for its absorbent effect. Iodine may be applied externally. When the effu- sion is great, paracentesis will be required. In the simple and tuberculous forms laparotomy has given encouraging results. ASCITES. Definition.—A collection of serous fluid in the perito- neal cavity. Etiology.—(1) It may result from one of the common causes of dropsy, viz: Bright's disease, chronic heart disease, chronic lung disease, anaemia, and especially cirrhosis of the liver. (2) Pressure of a tumor or displaced viscus upon the portal vein. (3) Chronic peritonitis. (4) Pressure upon the thoracic duct (Chylous ascites). 68 DISEASES OF THE DIGESTIVE SYSTEM. Symptoms.—When the effusion is large, a sensation of weight, dyspnoea, scanty urine, constipation, and oedema of the feet usually result from pressure. Physical Signs. Inspection.—The abdomen is distended, the surface is smooth and shining; the base of the thorax is broadened; the navel is more or less obliterated; the super- ficial veins are frequently enlarged; and, when the patient lies in the dorsal position, the flanks bulge. Palpation may elicit fluctuation, and in the flanks a sense of resistance. Percussion.—Dulness and resistance in dependent parts, with superincumbent tympany. Dulness is movable; it is detected in the flanks when the patient occupies the dorsal position. Aspiration.—The fluid is usually clear, straw-colored, and albuminous; the specific gravity is from 1012-1016. Diagnosis. Tympanites, or meteorism.—This yields uni- versal hyper-resonance on percussion. Ovarian Cysts.—The enlargement begins in the iliac fossa. The dulness is more or less immovable; as the intestines are pushed aside, there is dulness anteriorly, instead of tympany, as in ascites. Vaginal examination furnishes important data; the fluid has a higher specific gravity and often coagulates spontaneously. Distention of the Bladder.—The location of the dulness and resistance, the history, and the results of catheterization will render the diagnosis apparent. Treatment.—When possible, endeavor to remove the cause. Encourage free catharsis by the use of concentrated saline solutions, compound jalap powder (gr. xx-xxx), ela- terium (gr. §). Encourage free diuresis by the use of citrate of caffeine (gr. iij-v), infusion of digitalis (f.5ss), or Niemeyer's pill (page 80). !£. Potassii citrat., gss ; Tinct. scillse, f §ss ; Inf. digitalis, f.^iij ; . Aquae, q. s. ad fgvj.—M. Sig.—A tablespoonful thrice daily. If the effusion is very large, if the stomach is irritable, or DISEASES OF THE PANCREAS. 69 if internal remedies fail to give relief, tapping will be required. DISEASES OF THE PANCREAS. Until very recent years pathological conditions of the pan- creas have excited little attention, but careful study reveals the fact that the organ is not infrequently the seat of definite lesions which excite well-marked clinical phenomena; how- ever, in the present state of medical science these phenomena can rarely be attributed to their true cause. In chronic pan- creatic affections, wasting, fatty stools, and glycosuria are notable symptoms. Pancreatic Apoplexy.—A profuse hemorrhage excites sud- den pain in the pancreatic region, vomiting, abdominal disten- tion, and symptoms of collapse. It is almost invariably fatal. Acute Pancreatitis.—Causes unknown. The pancreas is enlarged, ecchymosed, and sometimes the seat of fatty degene- ration or abscesses. The symptoms are pain, fever, vomiting, and collapse. Cirrhosis Of the Pancreas (Chronic Interstitial Pancreatitis). — It probably results from the conditions which induce hepatic cirrhosis, viz., alcoholism, syphilis, etc. The pancreas is contracted and hardened, and microscopic examination reveals an overgrowth of connective tissue with atrophy of the secreting cells. Glycosuria, fatty stools, and inanition have been attributed to it. Pancreatic Calculi.—Concretions from the pancreatic juice sometimes lodge in the duct of Wirsung and excite colic ; their permanent impaction leads to the formation of cysts. Cancer Of the Pancreas.—May be primary or secondary. The most common seat is the head ; the most common variety is the scirrhus. Symptoms.—Pain, rapid emaciation, fatty stools, an im- movable tumor which often receives a pulsation from the underlying aorta ; sometimes jaundice and glycosuria. 70 DISEASES OF THE DIGESTIVE SYSTEM. DISEASES OF THE LIVER. The liver is situated in the right hypochondrium, with a small part projecting through the epigastrium to the left hypo- chondrium. Area of Liver Dulness. — The absolute dulness (part un- covered by lung) extends in the mammary line from the upper border of the sixth rib to the costal margin; in the axillary line, from the eighth rib to the eleventh rib; in the scapular line, from the ninth rib to the eleventh rib ; in the median line, the upper border is lost in the cardiac dulness, while the lower border lies midway between the ensiform cartilage and the umbilicus. Slight dulness in the mammary line begins at the fifth rib. Palpation. Palpation of the liver is practised to determine position, size, form, and consistence; and to detect any tenderness or pulsation. Conditions in which the liver is palpable:— 1. In thin subjects, the edge is sometimes palpable under normal conditions. 2. In very young children, in whom the liver is always proportionately large. 3. In depression of the liver, as by a pleural effusion or by a consolidated lung. 4. When the suspensory ligament is relaxed and the liver " wanders." 5. In enlargement from any cause. 6. In certain abnormalities of form, as in the " tight-lace liver." Superficial Irregularities. — Small irregularities may be noted in cancer, syphilis of the liver, and atrophic cirrhosis. Large prominences are sometimes noted in tumors, abscesses, and hydatid cysts. Consistence.—The liver is firm to the touch in hypertrophic cirrhosis, cancer, congestion, and amyloid disease. In abscess JAUNDICE OR ICTERUS. 71 and hydatid disease the resistance is less marked, and some- times fluctuation can be noted. Tenderness.—The liver is tender in acute congestion, abscess, cancer, and in affections complicated with perihepatitis. Pulsation may be detected in the venous congestion resulting from tricuspid regurgitation, abdominal aneurism, in tumors of the left lobe resting on the aorta, rarely in aortic regurgi- tation. Percussion. Percussion determines size and resistance. The liver is uniformly enlarged in : (1) Congestion, active and passive. (2) Fatty infiltration. (3) Amyloid infiltration. (4) Hypertrophic cirrhosis. (5) Hypertrophy as in leucaemia and diabetes. Irregular enlargements of the liver are noted in : (1) Cancer. (2) Abscess. (3) Hydatid disease. (4) Syphilis. The liver is diminished in size in: (1) Atrophic cirrhosis, late stage. (2) Fatty degeneration. (3) Acute yellow atrophy. (4) Senile atrophy. The area of hepatic dulness may be diminished from certain extrinsic causes, namely, pulmonary emphysema and excessive tympanites. JAUNDICE OR ICTERUS. Definition.—Pigmentation of the tissues and secretions with bile-pigments. Varieties. — (1) Hepatogenous, or obstructive jaundice. (2) Haematogenous, or non-obstructive jaundice. Etiology of Hepatogenous Jaundice. — Obstruction to the outflow of bile leads to its accumulation and re-absorp- tion. Obstruction may be due to the following causes :— 1. Stricture of the bile-duct, congenital or acquired. 2. Catarrh of the bile-ducts, or of the duodenal mucous membrane around the orifice of the ductus choledochus. 3. Foreign bodies in the ducts; as gall-stones, parasites. 4. Tumors of the liver or of adjacent viscera compressing the 72 DISEASES OF THE DIGESTIVE SYSTEM. ducts. Fecal accumulations, a pregnant uterus, and displaced organs may similarly compress the ducts. 5. Lowered blood pressure in the vessels of the liver causing increased tension in the bile-ducts, as in the simple icterus of the newborn. (Frerichs.) Symptoms.—The skin, mucous membranes, and secretions are stained yellow. The discoloration is usually first noticed in the conjunctivae. The stools are light, the urine is dark, and in bad cases resembles porter. The pulse is usually slow, and the temperature slightly subnormal. There is always some mental depression, and in extreme cases delirium, convulsions, and coma may develop. Itching of the skin is often noted, and urticaria is a common complication. In grave cases sub- cutaneous ecchymoses may appear. Diagnosis.—Other discolorations, like the bronze hue of Addison's disease, and the green tint of chlorosis, must be dis- tinguished from jaundice; but in those cases the conjunctiva is white and the urine lacks bile. Etiology of Hematogenous or Non-obstructive Jaundice.—This form results from a disintegration of the blood, or a destruction of the liver substance. It is sometimes noted in pernicious anaemia, and other grave anaemias, but it more Commonly results from the action of some toxic agent on the blood; thus, it may be observed in poisoning by phos- phorus, arsenic, and other minerals; in snake-poisoning, in pyaemia, and in certain infectious fevers—as yellow fever, re- lapsing fever, malarial fever, and acute yellow atrophy. Symptoms.—Much the same as in obstructive jaundice, but the staining of the skin is usually not so intense, the stools still contain bile, and grave cerebral symptoms are more apt to develop. ICTERUS NEONATORUM. Physiological icterus in the newborn is slight, and probably results from the lowered pressure in the portal vessels caused by ligation of the umbilical vein, and the subsequent absorp- tion of bile from the tense capillary ducts. Pathological icterus in the newborn is marked, and com- CATARRHAL JAUNDICE. 73 monly proves fatal. It results from congenital stricture of the duct, syphilis of the liver, or septic infection tiirough the umbilical vein. ACHOLIA. (Cholaemia, Cholesteraemia.) This term is applied to a group of symptoms noted in dis- eases associated with a destruction of the hepatic substance, and probably dependent upon the retention of poisons which should have been eliminated by the liver. Etiology.—Acholia occurs in acute yellow atrophy, and sometimes at the close of cancer, cirrhosis, and fatty degene- ration of the liver. Symptoms. — Delirium, convulsions, stupor, and coma. Jaundice may or may not be present. Subcutaneous ecchy- moses and hemorrhages from mucous membranes are frequently observed. CATARRHAL JAUNDICE. (Catarrhal Hepatitis, Catarrh of the Bile-ducts.) Etiology.—(1) The most common cause is the extension of a gastro-duodenal catarrh into the ducts. (2) Primary in- flammation of the ducts may result from exposure to cold and wet. (3) It may be induced by irritation from gall-stones. (4) It may be infectious, complicating malaria, pneumonia, relapsing fever, and similar diseases. Pathology.—The large ducts are particularly affected; the mucous membrane is swollen and covered with tenacious mucus. When the gall-bladder is compressed, bile is ejected with less ease than is natural through the duodenal orifice. When the catarrhal process is long-continued, ulceration of the ducts, or secondary cirrhosis (biliary cirrhosis) may result. Symptoms.—(1) Symptoms of gastro-duodenal catarrh usually precede. These are: Coated tongue, anorexia, fetid breath, epigastric distress, vomiting, and perhaps diarrhoea. (2) Obstructive jaundice, indicated by yellow skin and con- junctivae, light stools, and dark urine. (3) In acute cases, 74 DISEASES OF THE DIGESTIVE SYSTEM. slight fever and swelling of the liver, which is tender to the touch. Diagnosis.—Usually easy ; the exclusion of other causes of jaundice, and the consideration of the age, acute onset, and preservation of health will usually make the diagnosis appa- rent. Prognosis.—Favorable. It rarely becomes chronic and leads to biliary cirrhosis and ulceration of the ducts. The average duration is from a few days to several weeks. Treatment.—Rest. Liquid diet. Stupes of turpentine or of dilute nitrohydrochloric acid may be applied locally. Mild laxatives are often indicated ; calomel may be selected. J$l Hydrarg. chlor. niit., gr. ij ; Sodii bicarb., 3j.— M. Ft. in chart. No. xii. Sig.—One every hour until a laxative effect is produced. For the gastro-duodenal catarrh, mineral waters^ subnitrate of bismuth (gr. xx), nitrate of silver (gr. ^ q. d.), chloride of ammonium (gr. x, q. d.), phosphate of sodium (3j q. d.), are valuable adjuncts. In persistent cases the daily irrigation of the bowel with cold water (1-2 quarts) has been highly recom- mended ; the injections stimulate peristalsis and thus favor the expulsion of mucus and bile from the ducts. BILIARY CALCULI. (Gall-stones, Cholelithiasis.) Definition.—Concretions formed in the gall-bladder, and composed for the most part of bile-elements. Etiology.—Female sex, age (after forty), heredity, seden- tary habits, a rich diet, diseases of the liver which obstruct the flow of bile, as tumors, and catarrh of the ducts. Pathology.—The stones may be found in the ducts, but they are always formed in the gall-bladder. There may be one or several hundred. Wheu multiple, they are found with facets, from attrition. The size varies from a grain of sand to a large walnut. The color varies from a light yellow to a dark green. The chief constituent is eholesterin, but bile- BILIARY calculi. 75 acids, bile-pigments, lime, and magnesia also enter into their composition. On section, they usually present a concentric arrangement. The pathogenesis is not known ; a chemical change in the bile probably leads to a precipitation of the cholesterin. Events.—(1) Stones often remain latent in the bladder. (2) They may pass out with pain and spasm (biliary colic). (3) Impaction. A stone may obstruct the cystic duct and lead to distention of the bladder with mucus. More frequently the common duct is obstructed near its duodenal orifice, when the following symptoms result: Permanent jaundice, tenderness, exacerbations of pain, and peculiar paroxysms of fever, chills, and sweats, resembling malaria (Charcot's intermittent). Such paroxysms are not necessarily dependent on suppuration, although abscess may follow obstruction. (4) Perforation into the abdominal sac, stomach, or intestine. External per- foration is very rare. (5) After exit, stricture of the duct may result from ulceration, or intestinal obstruction, from impaction. Symptoms of Biliary Colic.—Sudden and intense pain over the liver, radiating to the back and to the right shoulder. It usually occurs an hour or two after eating. A rigor with fever may mark the onset. The symptoms of intense pain are obvious—anxious face, cold sweat, feeble pulse, and vomit- ing. Jaundice may follow from obstruction. If the stone escapes, it may be found in the stool. Diagnosis. Renal Colic.—Pain radiates from the kidney down the ureter to the penis; blood in the urine; no jaundice. Intestinal Colic.—Pain radiates from the umbilicus; flatu- lence ; no jaundice; no stone recovered. Gastralgia.—Pain referred to stomach and back; no jaun- dice ; no stone recovered. Prognosis.—The attack usually ends favorably. Recur- rence is common. The prognosis, as regards ultimate recovery, should be guardedly favorable; complications are comparatively rare. Treatment. The Attack.—Hot fomentations. Morphia (gr. i- to \) with atropia (gr. jfo) hypodermically. In aggra- vated cases anaesthetics will be required. 76 DISEASES OF THE DIGESTIVE SYSTEM. The Interval.—A regulated diet, largely vegetable. System- atic exercise should be enjoined. The flow of bile should be encouraged by the use of minera) waters, phosphate of sodium, or a vegetable cholagogue, like podophyllin or euonymin.- Catarrh of ducts should be relieved so that stones may escape. In impaction the same treatment is indicated with counter- irritation, and the use of some intestinal antiseptic, such as salol, naphthol, or the salicylate of bismuth, to replace the antiseptic elements of the bile. In aggravated cases an exploratory incision should be made, when a stone may be removed from the common duct (chole- dochotomy), or from the gall-bladder (cholecystotomy), or the gall-bladder removed (cholecystectomy). HYPEREMIA OF THE LIVER. Varieties.—(1) Active hyperaemia. (2) Passive hyper- aemia. Etiology.—Active hyperemia is commonly due to dietetic indiscretions (biliousness). It may result from over-indulgence in alcohol. It is often present in the infectious fevers. It appears to arise idiopathically in hot climates. Passive hypercemia results from diseases which obstruct the venous circulation, as chronic heart and lung disease. Pathology.—The liver is enlarged and filled with blood. In the passive variety, the centre of the lobule-, the area of the hepatic vein, is deeply pigmented, while the periphery, the area of the portal vein, is pale. This mottled appearance has given rise to the term " nutmeg liver." In persistent cases, pigmentation, atrophy of liver-cells, and overgrowth of con- nective tissue result—a condition termed "cyanotic indura- tion." Symptoms. Active hypercemia.—It is associated with gastric catarrh, and the usual symptoms are : Coated tongue, fetid breath, anorexia, pain and tenderness in the epigastric and hypochondriac regions, nausea, vomiting, sick-headache, and sometimes slight jaundice. The liver may be enlarged In the passive variety, the symptoms are the same, though CIRRHOSIS OF THE LIVER. 77 less marked. The liver is often quite large, and in extreme cases, such as follow tricuspid regurgitation, it may pulsate. Prognosis.—-In simple active congestion the prognosis is good. In passive congestion the prognosis depends on the cause. Treatment. Active hypercemia from dietetic errors—Re- strict the diet, apply counter-irritants, and administer calomel and soda, thus :— I£ Hydrarg. chlor. mit., gr. j ; Sodii bicarb., gj.—M. Ft. iu chart. No. vi. Sig.—One every hour until three or four have been taken. Follow the calomel with a laxative dose of sodium phos- phate, Carlsbad or Rochelle salts. In recurring attacks of biliousness, in addition to dietetic and hygienic directions, the following will prove useful:— IJ. Mass. hydrarg., gr. v; Pulv. rhei, Ext. gentian., aa 33s ; 01. caryophyll. gtt. iv.—M. (Hartshorne.) Div. in pil. No. xx. Sig.—One or two occasionally, as directed ; to be continued if re- quired, thrice daily for several days. In passive congestion, direct the treatment to the original disease. In mild cases the mineral waters do well (Carlsbad, Congress, and Friederichshall). A mercurial laxative may be used from time to time. In obstinate cases the concentrated salines may be employed as purgatives, and wet cups applied to the liver. CIRRHOSIS OF THE LIVER. (Hob-nailed Liver, Interstitial Hepatitis, Gin-drinker's Liver.) Definition.—A chronic disease characterized anatomically by a hyperplasia of the connective tissue and destruction of the secreting cells, and manifested chiefly by symptoms of portal obstruction. Etiology.—Male sex and middle life are generally predis- posing factors. (1) The abuse of spirituous liquors is a com- 78 diseases of the digestive system. mon cause. (2) It follows. chronic diseases which alter the crasis of the blood, viz : Syphilis, gout, malaria, and tubercu- losis. (3) It results from the passive congestion induced by chronic heart and lung disease. (4) It may be secondary to inflammation of the bile-ducts. It is sometimes seen in children; and in them, congenital syphilis and the infectious fevers appear to be the exciting causes. Pathology.—Two varieties have been recognized: (1) Atrophic cirrhosis, and (2) hypertrophic cirrhosis. Atrophic Cirrhosis.—In the early stages the liver is some- what large from hyperaemia. In the advanced stage the liver is small, firm, gray in color, and covered with numerous granulations (" hob-nails"). A section of the liver presents a network of fine and of coarse pearly bands of connective tissue. The contraction of this connective tissue is responsi- ble for the reduction in size and granular surface. Microscopic examination reveals an overgrowth of connective tissue; and, from interference with nutrition, fatty infiltration, fatty degeneration, atrophy of cells, and pigmentation. Hypertrophic Cirrhosis.—This term has been applied to the first stage of the atrophic form, and to a large liver resulting from the combination of cirrhosis with fatty infiltration. More recently, the term hypertrophic, or biliary cirrhosis, has been restricted to a condition in which the connective- tissue hyperplasia starts from the periphery of the capillary bile-ducts instead of from the ramifications of the portal vein, as in atrophic cirrhosis. The symptoms of portal obstruction are not marked, but jaundice is a prominent feature. The liver is large, yellow in color, and its surface is smooth or finely granular. The increased size is due to a great over- growth of connective tissue, and to preservation of the hepatic parenchyma. Symptoms of Atrophic Cirrhosis.—Obstruction to the portal circulation induces congestion of the stomach and intes- tines, and hence the initial symptoms are those of gastrointes- tinal catarrh. These are: Coated tongue, anorexia, fulness and distress after eating, vomiting of frothy mucus, flatulence, con- stipation, and .dark urine. These phenomena may last for months or years. CIRRHOSIS OF THE LIVER. 79 As the obstruction becomes greater, the portal blood finds new channels, and the superficial abdominal veins enlarge, notably around the umbilicus, forming the so-called " caput medusae." Hemorrhoids result from the same cause. Engorgement of the portal system leads to ascites and swell- ing of the feet, to hemorrhage from the stomach, bowel, or some distant organ, and to enlargement of the spleen. Physical Examination.—The liver is at first large, but is subsequently contracted. There is loss of flesh and strength. The skin is muddy in appearance. Jaundice is not common, and when present, results from catarrh of the bile-ducts. Death results from exhaustion, hemorrhage, intercurrent disease, or from a group of cerebral symptoms (delirium, convulsions, and coma) which are probably due to the retention of some toxic agent which the liver should eliminate. Hypertrophic Cirrhosis.—Jaundice is marked. The fiver is enlarged, smooth, and firm. Symptoms of portal obstruction, such as dropsy and hemorrhages, are not marked. The spleen is swollen. The disease may last one or two years, but an abrupt termination in convulsions and coma may occur at any time. Complications.—Tuberculosis, interstitial nephritis, cardiac hypertrophy, and hemorrhage. Diagnosis.—In the early stage the diagnosis can only be suspected. In the drunkard, chronic gastric catarrh with en- largement of the liver would strongly indicate cirrhosis Cancer.—History, greater cachexia, jaundice more common, and ascites less frequent, liver eularged aud studded with nodules, other organs affected, pain, and short duration. Chronic Peritonitis with effusion.—This is usually tuberculous or cancerous. The short duration, the abdominal tenderness, the lack of a uniform enlargement from bands of lymph, the absence of symptoms indicating portal obstruction, the normal size of the liver, after tapping, and the turbid sanious fluid will indicate chronic peritonitis. Prognosis.—Unfavorable. It may be arrested in the early stage. The entire duration may be many years, but death usually results in from one to three years after symptoms of portal obstruction have appeared. 80 DISEASES OF THE DIGESTIVE SYSTEM. Treatment.—Light nutritous diet. Rest. Alcohol must be interdicted. Treat the gastric catarrh with nitrate of silver, bismuth, mineral waters, and antiseptics (creosote or salicylate of bismuth). Iodide of potassium in small doses, well diluted, may be of service in the early stage. Counter-irritation over the liver should be frequently practised. Ascites.—Concentrated saline purges in the morning (Epsom salts 3ss in enough water to dissolve it). Diuretics, as digitalis or caffeine. Niemeyer's pill may be useful: $. Mass. hydrarg., gr. xij ; Pulv. digitalis, gr. xij ; Pulv. scillae, gr. xij.—M. Ft. in pil. No. xii. Sig. —One pill thrice daily. When the effusion is very large, internal remedies fail, and paracentesis will be required. The Operation.—Empty the bladder. Anaesthetize a point in the linea alba midway between the umbilicus and pubis. Tap with a small trocar, and have a long rubber tube at- tached to the canula for conveying the liquid into a conve- nient receptacle. When the liquid stops flowing withdraw the canula, cover the wound with adhesive plaster, and apply an abdominal binder. Observe strict antisepsis. The operation is free from danger. ABSCESS OF THE LIVER. Etiology.—(1) The presence in the liver of the amoeba coli of dysentery. (2) Traumatism. (3) Foreign bodies, gall- stones, retained bile, and hydatid cysts. (4) Septic emboli; they may come through the hepatic artery, but usually they come through the portal vein from gastric ulcers, or the ulcers of dysentery, typhlitis, or typhoid fever, and produce a puru- lent inflammation of the vein (suppurative pylephlebitis). Pathology.—The abscess following amoebic dysentery is often single, and usually occupies the right lobe. Embolic abscesses are always multiple. Events.—Hepatic abscess may kill by exhaustion or by rupture into adjacent viscera. Recovery may follow after CANCER OF THE LIVER. 81 operation or spontaneous evacuation ; and the latter may be external,through the bronchial tubes,or through the bowel. Symptoms.—Hectic symptoms : Fever, high in the evening and low in the morning, sweats, and chills. Local symp- toms : The liver is enlarged, painful, and tender. There may be bulging and even fluctuation. Pus may be detected by the aspirating needle. Jaundice from obstruction is sometimes present. Diagnosis. Hydatid Cysts.—Long duration, history, clear fluid on aspiration, absence of pain, and absence of hectic symptoms. Cancer.—History, cachexia, the involvement of other organs, multiple and firm nodules, and absence of hectic symptoms. Intermittent Fever due to impacted calcxdi.—Periodic, of long duration, absence of fever in the intervals, and fair preserva- tion of health. Prognosis.—Embolic abscesses (multiple) prove invariably fatal. Traumatic abscesses or abscesses due to a amoebic dysentery may terminate favorably after spontaneous or in- duced evacuation. Treatment.—Hot applications, opium, quinine, and stimu- lants. When the history indicates a single abscess, invoke sur- gical aid. CANCER OF THE LIVER. Etiology.—Male sex, age (after forty), heredity, and trau- matism are predisposing factors. Pathology.—It is generally secondary. The liver is en- larged, and studded with numerous grayish-white nodes, some of which project from the surface. The superficial nodes are often depressed at the centre. Symptoms.—(1) Severe pain and tenderness. (2) Cachexia, i. e. loss of flesh and strength, with pallor. (3) Pressure- symptoms : jauudice is common but ascites is rare. (4) Phy- sical examination : the liver is enlarged, its surface is nodular, and the central depression, or umbilications, can often be detected. (5) Symptoms of the primary growth which is usually in the stomach. 6 82 DISEASES OF THE DIGESTIVE SYSTEM. Fever is generaly absent, but secondary perihepatitis or suppuration of the cancerous nodules may induce it. Diagnosis. Hypertrophic Cirrhosis.—Liver is smooth and painless, the duration is longer, cachexia is not marked, and there is no indication of a primary cancer. Hydatid Cysts.—Health preserved, tumor elastic or fluctuat- ing, no pain, jaundice uncommon, aspiration yields a clear fluid containing hooklets. Abscess.—-History, short duration, hectic fever, and results of aspiration. Prognosis. — Absolutely fatal. Duration, from a few months to a year. Treatment.—Pall iati ve. AMYLOID LIVER. (Waxy Liver, Lardaceous Liver.) Definition.—An enlargement of the liver due to the de- position of an albuminoid substance. Etiology.—(1) Prolonged suppuration ; (2) syphilis ; (3) tuberculosis, and (4) chronic malaria are causal factors. Pathology.—The liver is very large, hard, and smooth. The edge is blunt. On section, the surface is " waxy," and a dilute solution of iodine strikes a mahogany-red color with the amyloid material. The degenerative process begins in the walls of the capillaries and spreads to the connective tissue. Symptoms.—Failure of general health with anaemia. The liver is enlarged, smooth, firm, and painless, and presents a blunt edge. The spleen and kidneys share in the degeneration, and, as a result, the spleen is enlarged and the urine is albu- minous. Diagnosis.—The history, the smooth, painless, enlarge- ment of the liver without jaundice, and the involvement of the kidneys and spleen, are the diagnostic phenomena. Prognosis.—Unfavorable. Treatment.—Remedies must be directed to the causal disease. Nutrients and tonics are indicated. Absorbents, like the iodides, mercurials, and ammonium chloride, have been recommended, but are valueless. HYDATID CYSTS OF THE LIVER. 83 HYDATID CYSTS OF THE LIVER, (Echinococcus of the Liver.) Etiology and Pathology.—Hydatid cysts are formed by the embryos of the taenia echinococcus, a small tape-worm inhabiting the intestines of the dog. The eggs of the worm are accidentally ingested by man, and embryos are liberated in the stomach, whence they may migrate to any organ ; the liver however is most commonly affected through the portal vein. The fixed embryo soon develops into a cyst which is composed of an external laminated layer and an internal breeding layer. A connective-tissue layer is formed on the outside from irritation. The cyst contains a clear non-albuminous fluid which has a specific gravity of 1005 to 1007, and which is rich in chlorides. Scolices or larvae develop from the breeding layer; they are provided with four suckers and a circle of hooklets, and produce daughter-cysts within the parent-cyst. When ingested by the dog the larvae develop into mature tape-worms. Symptoms.—Small cysts excite no symptoms. There is often a slowly-developing, irregular enlargement of the liver; if the cyst is superficial, an elastic or fluctuating mass may be detected on palpation. On percussion a peculiar vibratory sensation (hydatid thrill) may be imparted to the hand. Aspiration yields a clear fluid containing hooklets and chlorides. Fever, pain, and jaundice are usually absent. Events.—(1) It may reach a certain size, and then remain latent. (2) Trifling injury may convert it into an abscess. (3) Rupture of the cyst externally or into neighboring organs may result in death or in recovery. Diagnosis.— Slow development, irregular enlargement, elastic feel, the results of aspiration, and the absence of pain, fever, and jaundice are the diagnostic features. Suppurating cysts will be diagnosed abscesses. An upward-growing cyst may present the signs of a pleural effusion. Prognosis.—-Guardedly favorable. Treatment.—When large, aspirate. If the fluid re-collects, open and drain. 84 DISEASES OF THE DIGESTIVE SYSTEM. ACUTE YELLOW ATROPHY. (Malignant Jaundice.) Definition.—A rare and grave disease characterized ana- tomically by a rapid destruction of the liver tissue, and mani- fested by jaundice, hemorrhages, a reduction in the size of the liver, and marked cerebral phenomena. Etiology.—-Female sex, pregnancy, early life, are predis- posing factors. Alcoholic excesses, emotional excitement, and syphilis have been given as exciting causes. The rapid course, widespread lesions, and the fact that it has occurred endemically suggest an infectious origin. Pathology.—From destruction of its substance the liver is quite small. The capsule, being too large for the shrunken organ, is wrinkled. The surface is yellowish-red and mottled. Histology.—Fat drops, molecular debris, fat crystals, and crystals of leucin and tyrosin take the place of normal liver- cells. The other organs reveal fatty degeneration. Symptoms.—(1) The initial symptoms, which are those of catarrhal jaundice, are : Malaise, slight fever, coated tongue, nausea, vomiting, and jaundice. (2) Nervous symptoms fol- low ; these are: Severe headache, delirium, convulsions, and coma. Sometimes these symptoms precede the jaundice. (3) The urine is scanty, and contains albumin, blood, tube-casts, and crystals of leucin and tyrosin. (4) Hemorrhages are com- mon, the skin may be covered with ecchymoses, and bleeding from the mucous membranes may occur. (5) The area of hepatic dulness is diminished, but the area of splenic dulness is increased. Diagnosis.—The grave cerebral symptoms, reduced hepatic dulness, and hemorrhages will separate it from catarrhal jaun- dice. Phosphorus-poisoning.—History, phosphorus in the urine, primary enlargement of the liver, and the great severity of the initial gastric symptoms. Prognosis—Almost invariably fatal. Death results within a week after the appearance of cerebral symptoms. Treatment.—Palliative. DISEASES OF THE KIDNEYS. THE URINE. Normal urine is a pale, amber-colored fluid, of acid reaction, having a specific gravity of 1015 to 1025, and amounting in quantity to about fifty ounces in twenty-four hours. Polyuria.—An increased flow of urine. Temporary polyuria results from : (1) Excessive ingestion of fluids. (2) Diuretics. (3) Suppression of perspiration. (4) Crises of certain febrile diseases, and certain neurotic manifes- tations, such as excitement, neuralgia, and hysteria. (5) Ab- dominal enlargements, as in pregnancy, effusions, and tumors. (6) Removal of some temporary obstruction in the urinary passages. Permanent polyuria results from : (1) Diabetes mellitus. (2) Diabetes insipidus. (3) Chronic interstitial nephritis. (4) Amyloid kidney. The urine is diminished or suppressed (anuria) in the fol- lowing conditions: (1) Excessive secretion through other channels, as in free perspiration and diarrhoea. (2) In fever. (3) Passive renal congestion, from obstructive heart, lung, or liver disease. (4) Organic obstruction in the urinary pass- ages. (5) In acute and chronic parenchymatous nephritis. (6) Nervous causes, as in hysteria, and in the reflex inhibition after abdominal injuries or operations. Urea.—Urea results from the perfect decomposition of the nitrogenous elements of food and tissues. It is perfectly solu- (85) 86 DISEASES OF THE KIDNEYS. ble in urine, but the nitrate of urea crystallizes in the form of transparent imbricated plates when nitric acid is added to urine that has been partially evaporated. The amount of urea excreted varies greatly in health. Nor- mal urine contains about 2 to 2J per cent, of urea. It is increased: (1) After the ingestion of much albuminous food. (2) After exertion. (3) In acute inflammatory pro- cesses and in fevers. (4) In diabetes. It is diminished: (1) In nephritis. (2) In organic diseases of the liver. (3) In wasting diseases and in anaemia. (4) In starvation. Fowler's Hypochlorite Test for Urea.—Add to 1 volume of the urine 7 volumes of Labarraque's solution of chlorinated soda. Shake the jar containing the mixture occasionally, and stand it aside for two hours, when the urea will have been decomposed. Now take the specific gravity of the quiescent fluid. 2d. Ascertain the specific gravity of the mixture of urine and Labarraque's solution before decomposition. To do this, mul- tiply the specific gravity of the pure Labarraque's solution by 7, add this to the specific gravity of the pure urine, and divide by 8. The result is the specific gravity of the mixed fluid. From this subtract the specific gravity of the quiescent mix- ture after decomposition of the urea, multiply the difference by .77, and the result is the percentage of urea.—Tyson. Litliuria.—Uric acid or urates in the urine. These sub- stances are formed by the imperfect metamorphosis of tissues and nitrogenous food. When they are in excess the urine is heavy, dark in color, and on cooling throws down a brick-red deposit, termed " lateritious" (later, a brick). Microscopically, uric acid appears as reddish-yellow rhombic prisms or lozenge-shaped crystals. Amorphous urates appear as fine, dark, and opaque granules. Crystalline urates appear as needles, dumb-bells, or as globular masses from which sharp spines project. Murexide Test for Uric Acid and its Salts.—Evaporate a little urine in a porcelain dish, add a drop or two of strong nitric acid, and heat again to dryness. Cool, and add a drop of THE URINE. 87 liquor ammoniae, and the beautiful purple color of murexide is developed. Fig. 3. Uric acid and uric acid salts. Urates.—The urates are present in small quantity in normal urine. They may become perceptible or transiently increased : (1) In urine exposed to a cold atmosphere. (2) In urine made scanty by free perspiration or diarrhoea. (3) When the acidity of the urine is temporarily increased. (4) After the excessive indulgence in nitrogenous food. The urates are increased pathologically in many diseases which directly or indirectly interfere with tissue or food metab- olism, notably in: (1) Lithaemia or the gouty diathesis. (2) Fever. (3) Extreme anaemia, (4) Diseases of the lungs— from interference with oxidation. Leucin and Tyrosin.— These substances are found in the urine in certain specific fevers, in grave anaemia, and especially in fatty degeneration of the liver resulting either from phos- phorus-poisoning or acute yellow atrophy. Thev may be detected by evaporating a few drops of the urine on a glass slide. Leucin appears in the form of small, round, glistening spheres, resembling fat drops, but unlike the latter they are insoluble in ether. Tyrosin appears in the form of intersecting tufts of fine acicular crystals. 88 DISEASES OF THE KIDNEYS. Fig. 4. a. Tyrosin crystals, b. Leucin crystals. Phosphates.—There are two forms, amorphous and crystal- line. Amorphous earthy phosphates are found in alkaline urine, and are precipitated by adding a few drops of liquor ammoniae to the urine. Crystallized phosphate of lime appears as stellar or rod- shaped crystals which are soluble in acetic acid. Fig. 5. Triple phosphate. The ammonio-magnesian phosphate, or triple phosphate, ap- pears in decomposing urine as transparent coffin-shaped prisms. They may resemble crystals of oxalate of lime, but, unlike the latter, are freely soluble in acetic acid. THE URINE. 89 The presence of phosphates in the urine is no indication of excess, for when normal in amount they are often precipitated in urine that is temporarily alkaline. The detection of triple phosphates in newly-voided urine indicates decomposition in the bladder, a condition resulting from vesical catarrh. Phosphates are often increased in nervous dyspepsia, melan- cholia, and neurasthenia. Chlorides.—The quantity of these salts is increased: (1) After exertion. (2) During the absorption of mechanical or inflammatory effusions. (3) In intermittent fever, from the destruction of corpuscles. The quantity is decreased : (1) In most febrile diseases. (2) In nephritis. (3) In many wasting diseases. (4) Espe- cially in pneumonia. Test.—We may thus roughly estimate the quantity. Add a few drops of strong nitric acid to the urine, remove any albumin that may be present, and then add to the clear urine a little of a strong solution of nitrate of silver. The abund- ance of the white precipitate will indicate the quantity of chlo- rides present. Fig. 6. Oxalate of lime. Oxaluria.—Oxalate of lime appears in the urine as dumb- bell-shaped crystals, or as minute highly refracting octahedra. 90 DISEASES OF THE KIDNEYS. Many conditions produce them. They are found : (1) After eating certain fruits and vegetables, as rhubarb, cauliflower, and pears. (2) In certain diseases, notably nervous dyspepsia, hypochondria, melancholia, diabetes, and wasting diseases. In these cases the oxalates result from the imperfect metab- olism of organic substances. Urobilinuria.—Urobilin is a coloring principle derived from the blood. When present in the urine in large amount it pro- duces a reddish-brown color ; when deposited in the tissues it produces a form of jaundice which has been called urobilin- icterus (Jaksch). Urobilinuria occurs: (1) Occasionally in health. (2) In pyrexia. (3) After the absorption of hemorrhagic effusions. (4) In liver disease. (5) In grave anaemia. Glucosuria, or Glycosuria.—Glucose in the urine. Its Causes.—(1) Normal urine contains a trace. (2) Diabetes mellitus. (3) Certain diseases, as gout, chorea, tetanus, and functional nervous affections. (4) Ingestion of much sacchar- ine or amylaceous material. (5) Pregnancy. (6) Toxic sub- stances in the blood, as the nitrites and carbon monoxide. Qualitative Tests for Glucose.—The copper tests are commonly employed, and depend on the power which glucose possesses of converting blue oxide of copper into the orange-yellow sub- oxide. Trommer's Test.—Add to the suspected urine half its volume of liquor potassae, and if any precipitate falls filter the solution ; then add one or two drops of a weak solution (1-30) of sulphate of copper, and heat the resulting mixture. If sugar is present, a dense yellow or red precipitate falls. Simple decolorization of the fluid is no proof of sugar. Fehling's Test.—As the fluid employed in this test spoils on keeping, it should be freshly prepared when required by mix- ing in equal proportions the following solutions:— First solution : Dissolve 34.64 grams of pure cupric sul- phate in distilled water, and dilute up to 500 cubic centi- meters. Second solution: Dissolve 180 grams of pure Rochelle salt and 70 grams of caustic soda in 400 cubic centimeters of dis- THE URINE. 91 tilled water, and heat to boiling; on cooling, make up to 500 cubic centimeters with distilled water. To about ten minims of each solution in a test-tube add about a fluid drachm of distilled water, and boil for a few sec- onds ; if the solution remains clear, add the suspected urine drop by drop, and occasionally heat the tube. If sugar is abundant, a yellowish-red deposit will be produced. If no precipitate falls, continue the addition of the urine until an equal volume has been added, and allow to cool; then if no precipitate falls, sugar is absent. Pacy's Solution may be used instead of Fehling's solution. It- contains 320 grains of sulphate of copper, 640 grains of neutral tartrate of potassium, 1286 grains of caustic potash, and 20 fluidounces of distilled water. As other organic sub- stances and urochloralic acid (after administration of chloral) yield precipitates of the suboxide of copper, Bottger's test or the fermentation test may be employed as guard tests. Bottger's Test.—Add to a couple of drachms of suspected urine which is free from albumin an equal volume of liquor potassie and a few grains of subnitrate of bismuth, and boil; if sugar is present, it will reduce the salt of bismuth to black metallic bismuth. Substances containing sulphur, like albu- min, yield a similar black precipitate. The Fermentation Test.—Fill a four-ounce bottle three parts full of urine, and add a fluid drachm of ordinary yeast, or a small portion of compressed yeast, lightly cork, and subject to a temperature of 70° to 80° Fahr. for ten or twelve hours. If sugar is present, fermentation results with the evolution of carbon dioxide, and the specific gravity of the urine falls. Quantitative Tests.—Fermentation test: Employ two bottles of urine, and to the one add the yeast; at the end of twenty- four hours take the specific gravity of each specimen. Every degree lost in the fermented urine indicates a grain of sugar to the fluidounce. Fehling's Test.—To one cubic centimetre of Fehling's solu- tion add four cubic centimetres of distilled water, and boil; if the solution still remains clear, add y1^ c. c. of the urine from a graduated pipette, and gently heat. Continue the ad- dition of the urine, little by little, until all blue color has dis- 92 DISEASES OF THE KIDNEYS. appeared. If one cubic centimetre of urine has been added, it will have contained half of one per cent, of sugar. If two c. c. are used, it will have contained one-quarter per cent. If but a half of a cubic centimetre is used, it will have contained one per cent. If the specific gravity indicates that the amount of sugar is great, dilute the urine with a definite amount of water, and estimate accordingly (Tyson). Albuminuria.—Albumin in the urine. Its Causes.—(1) All forms of nephritis. (2) Congestion of the kidney, as the result of chronic heart, lung, or liver dis- ease. (3) Pregnancy. (4) Cyclical. The urine may be albu- minous at certain times, as after meals, heavy exercise, bathing, or on rising in the morning. (5) Accidental. From the admix- ture of albuminous substances with the urine, as pus, semen, aud blood. (6) Certain nervous diseases, as epilepsy, tetanus, and injury to the brain. (7) Extreme anaemia. (8) Ingestion of large amounts of albuminous food. Tests for Albumin. Heller's Test.—Pour a small quantity of colorless nitric acid in a test-tube, and allow an equal quantity of filtered urine to trickle from a pipette down the sides of the tube and to come in contact with the acid. If albumin is present, a sharply-defined white ring is formed at the line of junction. Turpentine, copaiba, and other oleoresins eliminated in the urine yield similar rings, but the latter are redissolved ou the addition of alcohol. Uric acid produces an undefined pink ring, but it is not exactly at the line of contact, and is redissolved on the ap- plication of heat. Johnson's Test.—Fill a six-inch test-tube two-thirds full of filtered urine, and allow a couple of drachms of a clear satu- rated solution of picric acid to flow down the side of the tube and to mix with the urine. Turbidity indicates the presence of albumin, and it increases on gently heating the tube near its mouth. Certain substances in the urine, like the alkaloids, produce a similar turbidity, but this disappears on the appli- cation of heat. THE URINE. 93 Roberts's Nitric MagnesianTest.—Very delicate and reliable. The test-fluid is made by adding; one volume of strong; nitric acid to five volumes of a saturated solution of sulphate of magnesium, and is employed in the same manner as nitric acid in Heller's test, Acetonuria.—Acetone results from the metamorphosis of albumin, and is found in the urine in many conditions, notably : (1) A trace in normal urine. (2) In Cancer. (3) Febrile diseases. (4) Psychoses. (5) It may arise as a primary condition. (Von Jaksch.) (6) In diabetes it is often abund- ant. It is not responsible for diabetic coma (Acetonaemia). Legal's Acetone Test.—To four c.c. of urine, rendered alkaline with liquor potassae, add a few drops ofa strong solution of sodium nitro-prusside. If the red color produced turns purple on the ad- dition of a few drops of concentrated acetic acid, acetone is present. Diaceturia and Oxybuturia.—Diacetic acid and oxybutyric acid are never found in normal urine, but are found associated with acetone in certain fevers, and especially in diabetes. Their decomposition yields acetone, and they are probably the cause of diabetic coma. Test for Diacetic Acid.—Boil the urine and add a solution of ferric chloride. If diacetic acid is present, a Burgundy-red color develops. Haematuria.—Blood in the urine. The chief causal conditions are: (1) Vicarious menstrua- tion. (2) Traumatism applied to any part of the genito- urinary tract. (3) General blood dyscrasia, as in the specific fevers, purpura, malaria, scurvy, etc. (4) Congestion of the kidney from chronic heart, lung, or liver disease. (5) Acute inflammation of any part of the genito-urinary tract. (6) Stone in the genito-urinary tract. (7) Varicose veins at the neck of the bladder. (8) It may occur paroxysmally without obvious cause. (8) Parasites in the genito-urinary tract, as the Filaria sanguinis hominis, and the Distoma haematobium. Diagnosis.—By the color of the urine and by microscopic and spectroscopic examination. Heller's Text.—Boil the urine with a solution of caustic potash, and phosphates are precipitated which assume a red color from the freed haematin. 94 DISEASES OF THE KIDNEYS. Source of the Hemorrhage. Urethra.—The urine first passed is bloody, and the other symptoms point to the urethra. Bladder. — Bleeding often at the end of micturition, and other symptoms, point to the bladder. Kidney.—Blood intimately mixed. There may be blood- casts, or clots, and the other symptoms point to the kidneys. Hemoglobinuria,—Blood-pigment in the urine. The chief causal conditions are: (1) Blood disintegration from the specific fevers, scurvy, purpura, malaria, etc. (2) Absorption of internal hemorrhagic effusions. (3) It follows transfusion of blood. (4) Paroxysmally, without obvious cause. Indicanuria. — Indican is a colorless compound resulting from the decomposition of albuminous substances in the small intestine, and by oxidation is converted into indigo. It occurs (1) Frequently in health. (2) From undue reten- tion of material in the small intestine, as in peritonitis, intes- tinal obstruction, and obstinate constipation. (3) In wasting diseases. (4) Purulent inflammations. (5) Asiatic cholera. Test for Indican.—Mix equal volumes of urine and fresh nitro-hydrochloric acid, and add, drop by drop, a fresh con- centrated solution of chloride of lime. Indican is indicated by the appearance of an indigo-blue color. Bile.—Bile-pigment is found in the urine in all forms of jaundice. Bile-acids in the urine indicate hepatogenous jaundice, but their absence in jaundice is no proof that the latter is haemoto- genous in origin. Gmellin's Test for Bile-pigment.—Allow a few drops of urine and a few drops of fuming nitric acid to come together on a white plate. If bile is present, there will be an iridescent play of colors—green, blue, violet, and red—at the line of contact. Pettenkoffer's Test for Bile-acids.—Add a few grains of cane- sugar and a drop of sulphuric acid to the suspected urine in a test-tube; heat gently, and if bile-acids are present a violet- red color is produced. Chyluria.—Chyle in the urine. It produces a milky tur- bidity which gradually rises to the top of the urine'in the form of pellicles of finely-divided fat. Its chief causes are: (1) Injury to the lymphatic ducts. (2) Pregnancy. (3) Obstruc- RENAL HYPEREMIA. 95 tion of the lymphatic ducts by the Filaria sanguinis hominis, a thread-worm most commonly met with in the tropics. Pyuria.—Pus in the urine. It results (1) from suppura- tive inflammation of any part of the genito-urinary tract, and (2) from the rupture of abscesses into the tract. It appears as a dull, greenish-yellow precipitate which is converted into a clear gelatinous mass by the addition of liquor potassae. It can always be detected by the microscope. Source.—When pus is from the kidney it is intimately mixed with the urine, the latter has an acid or neutral reaction, and the associated symptoms point to the kidneys. When the pus is from the bladder it is not so intimately mixed with the urine; the latter is usually alkaline in reaction, and the associated symptoms point to the bladder. RENAL HYPEREMIA. (1) Active hyperaemia, and (2) passive hy- Active Hyperaemia. (Acute Congestion.) Causes.—(1) Exposure to cold when the body is over- heated. (2) Eruptive fevers. (3) Poisons, as the stimulating diuretics. (4) Pregnancy. The same cause aggravated would produce acute nephritis. Pathology.—The kidney is swollen, of a deep red color, and bleeds freely on section. Microscopic examination reveals cloudy swelling of the renal epithelium. Symptoms.—Pain over the loins. The urine is dark, scanty, of high specific gravity, and may contain a trace of albumin, a few hyaline casts, and some free blood. Prognosis.—If the cause can be removed, the prognosis is favorable. Treatment.—Absolute rest. Wet cups or warm fomenta- tions over the loins. Liberal use of water. Saline laxatives. Encourage sweating by the vapor bath or small doses of pilo- carpin. The infusion of digitalis may be used to increase the quantity of urine. \tarieties. peraemia. 96 DISEASES OF THE KIDNEYS. Passive Hypersemia. (Chronic Congestion.) Etiology.—(1) Causes which obstruct the general circula- tion, as chronic heart, lung, and liver disease. (2) Pressure of tumors on the renal veins. (3) Rarely thrombosis of the renal veins. Pathology.—The kidney is swollen and of a bluish-red color, and later becomes hard from an overgrowth of con- nective tissue (cyanotic induration). In advanced cases the renal epithelium is fatty. Symptoms.—Sensation of weight over the loins. The urine is usually diminished, but is rarely increased in quantity. Free blood, a little albumin, and occasionally a few narrow hyaline casts are found. Diagnosis.—The comparative absence of albumin and casts, the absence of dropsy and uraemic symptoms, and the presence of urea in normal amount will separate congestion from nephritis. Prognosis.—Depends on the cause. Treatment.—Rest. Light diet. Dry cups to the loins. The use of diuretics when the urine is scanty. The following tonic diuretic pill may be of service :— J$l Quininae sulph., gr. xxx ; Pulv. digitalis, gr. xxx ; Pulv. scillae, gr. xxx ; Ext. nucis vomica?, gr. v ; Pulv. ferri carb., gr. xxx.—M (Pepper.) Div. in pil. No. xxx. Sig.—One pill every three hours. URAEMIA. Definition.—The name applied to a group of symptoms resulting from the retention of toxic materials in the blood which should have been eliminated by the kidneys. Symptoms.—It may develop slowly or abruptly, and may manifest any of the following phenomena: Headache, ver- tigo, delirium, epileptiform convulsions, coma, sudden blind- ACUTE nephritis. 97 ness (unassociated with any retinal change), and transient paralysis from congestion or oedema of the brain or cord. Pulmonary Symptoms.—Dyspnoea, (uraemic asthma), Cheyne- Stokes breathing. Abdominal Symptoms.—Hiccough, obstinate vomiting, and purging. General Symptoms.—The skin is dry; the breath has a urinous odor; the urine is scanty and deficient in urea. The pulse is slow and full, and the temperature subnormal; but during convulsions the temperature may rise and the pulse become rapid and feeble. Diagnosis.—The various manifestations may be recognized as uraemic by the history, the temperature, the odor of the breath, the high arterial tension, the accentuated second sound of the heart, the presence of casts and albumin in the urine, and by the absence of any other cause. Prognosis.—Grave, but always guarded, for recovery is possible after the most serious manifestations. Treatment.—Encourage sweating by the use of hot air, or vapor baths. Encourage catharsis by the use of croton oil (one drop in a drachm of olive oil), elaterium (gr. ^), or a concentrated solution of Epsom salts. Relieve renal engorgement by digitalis poultices, or dry or wet cups to the loins. When the patient is robust, and the pulse is strong, venesection will be of paramount impor- tance. If the pulse is very weak, alcohol, strychnia, digitalis, and ammonia may be required hypodermically. In convulsive seizures, in addition to the above treatment, chloral (gr. xxx-xl) may be given by the rectum, and nitrite of amyl or chloroform by inhalation. ACUTE NEPHRITIS. (Acute Bright's Disease, Acute Tubular Nephritis, Acute Desqua- mative Nephritis, Acute Parenchymatous Nephritis, Acute Catarrhal Nephritis.) Definition.—An acute inflammatory process involving more or less the whole kidney, but especially affecting the epithelium of the tubules and glomeruli. 98 DISEASES OF THE KIDNEYS. Etiology.—(1) Exposure to cold and wet. (2) The spe- cific fevers, especially scarlet fever. (3) Poisons which are eliminated through the kidneys, as cantharides, turpentine, etc. (4) Pregnancy. Pathology.—The kidney is swollen and the capsule non- adherent. At first the organ is bright red in color; it soon, however, becomes pale and mottled in appearance, although the Malpighian tufts still retain their deep red tint. Histology.—The epithelium of the tubules and glomeruli is the seat of cloudy swelling and, later, of fatty degeneration. Desquamated epithelium, blood-corpuscles, and an albuminous exudate block up the tubules. The capillaries are dilated, their walls degenerated, and bloody extravasations are not in- frequently seen. The interstitial tissue is more or less infil- trated with leucocytes. Symptoms.—Moderate fever and its associated symptoms; dull lumbar pain; nausea and vomiting; dropsy, beginning in the face and becoming general ; rapid anaemia. Uraemic symptoms may develop at any time. The Urine.—Scanty and at times suppressed. It is smoky in appearance, of high specific gravity, rich in albumin, and throws a heavy sediment, which contains hyaline, blood, and epithelial casts, and free blood and epithelial cells. Diagnosis.—As the general symptoms are often slight, the diagnosis must rest on the examination of the urine. The history, and the absence in the urine of wide, highly fatty casts, will serve to distinguish acute nephritis from an acute exacerbation of chronic parenchymatous nephritis. Prognosis.—Guardedly favorable. It may kill by ex- haustion, uraemia, or dropsy. Treatment.—Absolute rest in bed until albumin has dis- appeared from the urine. Milk is the best food ; but butter- milk, gruels, and light broths are admissible. The free use of water should be encouraged. Dry or wet cups, or hot fomen- tations should be applied to the loins. To secure vicarious action of the skin vapor baths or small doses of pilocarpin (gr. ^ to y^g) may be employed. Concentrated saline draughts, made of Rochelle or Epsom salts, may be given to secure watery discharges from the bowels. Compound jalap powder chronic parenchymatous nephritis. 99 (gr. xx), or elaterium (gr. |) may be substituted for the saline. Stimulating diuretics should be avoided, and diuresis encour- aged by alkaline waters and infusion of digitalis. Uraemia will call for its appropriate treatment. Severe cases in pregnancy will require the induction of abortion or premature labor. Marked effusions into the serous cavities will sometimes demand aspiration. Convalescence should be protracted, and the resulting anaemia will call for some preparation of iron, such as Basham's mixture. CHRONIC PARENCHYMATOUS NEPHRITIS. (Chronic Catarrhal Nephritis, Large "White Kidney.) Etiology.—(1) It may result from acute nephritis. (2) It may be chronic from the beginning. Male sex, adult life, frequent exposure to cold and wet, alcoholism, congestion from heart disease, and syphilis are predisposing factors. Pathology.—In the first stage the kidney is large and pale-yellow in color; the pallor depends on anaemia and fatty degeneration; the tubes are filled with fatty epithelium and casts; there is always some overgrowth of the interstitial con- nective tissue. In the second stage the organ is small, pale in color, its sur- face rough, and its capsule somewhat adherent. The reduced size depends on destruction of the renal epithelium and the contraction of the overgrown connective tissue. Symptoms. — As it usually begins as a chronic affection, the following symptoms slowly manifest themselves: Pro- gressive loss of flesh and strength ; marked anaemia; gastro- intestinal disturbances; dropsy, often first noted in the face on rising in the morning; increased arterial tension; some hypertrophy of the left ventricle, so that the second sound at the aortic cartilage is accentuated. Uraemic symptoms may develop at any time. The Urine.—Usually diminished, although it is frequently normal in color and in appearance. It is highly albuminous, and throws down an abundant sediment, which contains hya- line, fatty, and granular casts, and fatty epithelial cells. 100 diseases of the kidneys. Complications.—These are numerous and often suggest the diagnosis. The most common are uraemia, extensive dropsy into the tissues or serous cavities, latent inflammations of the serous membranes, valvular heart disease, albuminuric retinitis, and acute exacerbations. Prognosis.—Unfavorable. In the early stages recovery sometimes results. The duration is from a few months to several years. Treatment. — The treatment is largely dietetic and hygienic. Residence in a dry, warm, and equable climate may prolong life or effect a cure. Rest is an essential element in the treatment. The underclothing should be woollen or silk. The diet should be non-nitrogenous, and in severe cases an absolute milk diet may be of extreme value. The bowels should be kept active by natural mineral waters or saline laxatives. When the urine is scanty, digitalis or caffeine may prove an efficient diuretic. Basham's mixture may be em- ployed as a chalybeate and a diuretic. In excessive dropsy promote catharsis by Epsom salts in concentrated solution, or by compound jalap powder; and promote diaphoresis by the hot-air bath, or by pilocarpin. The following combination is often very efficient in trouble- some dropsy :— fy Mass. hydrarg., gr. xx ; Pulv. digitalis, gr. xx; Pulv. scillse, gr. xx.—M. (Niemeyer.) Ft. in pil. No. xx. Sig.—One pill thrice daily. Acute exacerbations should be treated as primary attacks of acute nephritis. CHRONIC INTERSTITIAL NEPHRITIS. (Red Granular Kidney, Contracted Kidney, Gouty Kidney.) Definition.—A chronic inflammatory condition of the kidney characterized by a reduction in its size, due to an over- growth and subsequent contraction of its connective-tissue elements, and invariably associated with general arterial scle- rosis and cardiac hypertrophy. CHRONIC INTERSTITIAL NEPHRITIS. 101 Etiology.—It may be secondary to parenchymatous nephritis, or result from the passive congestion of'chronic heart disease; but generally it arises as a primary condition, and results from the causes which predispose to sclerosis in other organs, viz., middle life, male sex, syphilis, the gouty diathesis, chronic alcoholism, and chronic mineral poisoning;, as from lead. Pathology.—The kidneys are small, and red in color. The surface is granular, and the capsule adherent. The or- gan is firm, cute with difficulty, and on section often reveals small cysts or calcareous deposits. The cortical substance is greatly reduced in thickness. Microscopic examination shows an overgrowth of connective tissue which has contracted, nar- rowed the lumen of the tubules, and interfered with the nutrition of the epithelium, and as a result the latter may show fatty degeneration with desquamation. The arteries throughout the body reveal fatty degeneration of the media and an overgrowth of connective" tissue in the intima (arterio- sclerosis), and from the resistance thus offered hypertrophy of the heart has resulted. Symptoms—A slow loss of flesh and strength with pro- gressive anaemia. Gastric disturbances are very common. The arteries are rigid, and the pulse is of high tension, so that the second sound of the heart is accentuated at the aortic carti- lage. Palpitation of the heart is often noted. Dyspnoea is a prominent symptom, and may result from heart-weakness, uraemia, or oedema of the lungs. Headache, vertigo, and insomnia often result from disturbed circulation, and dimness of vision from albuminuric retinitis. Dropsy is often absent, or is slight and appears late in the disease. The urine: Increased in quantity, pale in color, and of low specific gravity (1010-1005), and contains but a trace of albu- min and a few narrow hyaline casts. Complications. — Albuminuric retinitis, valvular heart disease, apoplexy resulting from the weakened arteries and large heart, uraemia, latent inflammations of serous mem- branes, pneumonia, and bronchitis. 102 DISEASES OF THE KIDNEYS. . Diagnosis.—The arterial changes, casts in the urine, uraemic symptoms, and the absence of poikilocytosis will serve to distinguish chronic nephritis from pernicious ancemia. Chronic parenchymatous nephritis usually occurs earlier in life, lacks much arterial change, produces considerable dropsy, and urine that is rich in albumin and tube-casts. Prognosis.—It is incurable, but may last many years, and under favorable conditions comparative comfort may be ob- tained. Treatment.—The dietetic and hygienic treatment is the same as in chronic parenchymatous nephritis. Frequent bath- ing with friction of the skin should be encouraged, and the bowels kept regular by alkaline waters. Absorbents, like the bichloride of mercury and iodide of potassium, are of no value. If the stomach will bear it, iron will be of service. Digitalis, caffeine, and strychnia will be very useful when the heart weakens. Nitroglycerin, in one minim doses, gradually increased, has been recommended for the high arterial tension. AMYLOID KIDNEY. (Waxy Kidney, Lardaceous Kidney.) Etiology.—(1) Prolonged suppuration, particularly in bone disease. (2) Tuberculosis. (3) Syphilis. (4) Malarial cachexia. Pathology.—The kidney is large and pale, and on sec- tion presents a "bacon-like" appearance. Lugol's solution of iodine strikes a mahogany-red color with the amyloid material. On microscopic examination, the walls of the bloodvessels, particularly those of the Malpighian tufts, are found thickened, and infiltrated with a homogeneous wax-like material, which turns red when treated with a weak solution of gentian-violet. Parenchymatous and interstitial changes are always noted. other organs, especially the liver and spleen, are similarly affected. Symptoms.—Loss of flesh and strength, with great pallor and moderate dropsy. Uraemic symptoms are uncommon. renal calculus. 103 The liver and spleen are often much enlarged from the same degeneration. The Urine.—Usually increased in amount, pale in color, and contains considerable albumin and wide hyaline and granular casts. Dtagnosis.—The history, the enlarged liver and spleen, and the increased amount of urine containing considerable albumin suggest the diagnosis. Prognosis.—AVhen not advanced, and the cause can be removed, the disease may be arrested. As a rule, the prog- nosis is decidedly unfavorable. Treatment.—The primary disease will claim attention. In bone disease, surgical interference may be requisite. In syphilis, iodide of potassium and mercurials will be indicated. In malarial cachexia, iron, quinine, and arsenic should be em- ployed. Tuberculosis will call for its appropriate remedies. The treatment of the morbid condition is hygienic and dietetic. Alterative tonics, like the iodide of iron, may prove beneficial in some cases. RENAL CALCULUS. (Nephrolithiasis, Renal Gravel.) Definition.—A precipitated urinary concretion found in the kidney. Etiology.—(1) Male sex. (2) Heredity. (3) Mal-assimi- lation. (4) Inflammation of the pelvis of the kidney. Doubt- less mucus or desquamated epithelium forms the nucleus upon which the stone is built. Varieties.—(1) Uric acid. This may be passed as sand, or form large reddish-brown stones (2) Oxalate of lime. This forms a very hard, dark, and uneven stone (mulberry calculus). (3) Phosphates. These are composed of phosphate of lime, and ammonio-magnesium phosphate, and are soft, mortar-like in appearance, and are often deposited on other calculi. (4) Xanthine and cystine are rare concretions. Events.—(1) A stone may remain latent indefinitely. (2) It may pass out, with or without the symptoms of colic. (3) It 104 diseases of the kidneys. excites pyelitis, and sometimes abscess of the kidney. (4) It may obstruct the ureter and produce hydro-nephrosis or pyo- nephrosis. (5) It may excite perinephritis, and may perforate in other organs. Symptoms of Renal Colic.—Sudden onset, with sharp pain, starting in the back and radiating down the ureter, the penis, testicle, or thigh. There may be retraction of the testi- cle on the affected side. The symptoms of intense pain are often present, viz: pallor, cold sweats, weak pulse, and reflex vomiting. The urine subsequently passed may contain the stone; or, as a result of irritation, pus, blood and desquamated pelvic epithelium. An attack may last from a few moments to several hours. Diagnosis. Biliary and Renal Colic.—In the former the pain runs from the right hypochondriac region to the right shoulder; there is often jaundice, and the urine is negative, while the stools may contain the stone. Prognosis.—In view of the complications the prognosis must be guarded. Treatment. The Attack.—Morphine and atropine should be employed hypodermically, and warm poultices applied to the loins. The free use of water should be encouraged. In severe cases chloroform or ether may be inhaled in sufficient quantity to obtund the sensibility of the patient. The Interval.—When symptoms persist, regulate the diet, and put the patient under good hygienic conditions. When the reaction of the urine indicates an acid stone, the salts of lithium or the vegetable salts of potash may be employed in large doses, over long periods. A drachm of the citrate of potassium or five to ten grains of the carbonate of lithium may be given, well diluted, several times a day. The natural mineral waters are of some value. The Buffalo lithia Mater may be employed for this purpose, and its palatableness and efficiency may be increased by the addition of a teaspoonful of some effervescing preparation of lithium to each potation. When an alkaline stone is indicated, benzoic acid or boric acid may be employed in a similar manner. In severe and persistent cases the stone may be excised pyelitis. 105 (nephrolithotomy); and if the operation should reveal a badly-damaged kidney, its removal (nephrectomy) would be indicated. PYELITIS. (Pyelonephritis, Pyonephrosis.) Definition.—Inflammation of the pelvis of the kidney. Etiology.—(1) It may result from stone in the pelvis of the kidney (calculous pyelitis). (2) It may be secondary to urethritis or cystitis extending upwards through the ureters. (3) It may follow pregnancy or the specific fevers. (4) Morbid growths, such as tubercle or cancer. (5) Toxic doses of the stimulating diuretics (copaiba, cantharides, etc.). (6) It is rarely idiopathic from exposure to cold and wet. Pathology.—The mucous membrane is swollen, injected, and covered with a tenacious secretion composed of mucus, pus, and desquamated epithelium. Severe cases may lead to dilatation of the pelvis, Bright's disease, or suppurative nephritis. Symptoms.—Moderate fever and its associated phenomena. In suppurative nephritis the fever may be irregular and asso- ciated with hectic or typhoid symptoms. There is pain and sometimes tenderness over the kidneys. The urine is turbid, acid in reaction, and on standing throws down a sediment con- taining considerable mucus, pus-corpuscles, pelvic epithelium, and blood-corpuscles. The pus and blood render the urine slightly albuminous. Diagnosis.—The absence of much albumin, of tube-casts, and dropsy exclude nephritis. Cystitis may be excluded by the absence of lumbar pains and of acid urine, and by the presence of frequent and painful micturition and alkaline urine containing vesical epithelium. Perinephritic abscess is also associated with lumbar pain and hectic fever; but in addition there is often oedema over the lumbar region, and the urine may be normal. Sharp pain over the kidney, increased by jarring movements, and reflected down the ureters, and the presence of much blood in the urine point to calculous pyelitis. 106 diseases of the kidneys. Tuberculous pyelitis may be recognized by the history, by the presence of tubercle in other organs, and by tubercle bacilli in the urine. Pyelitis secondary to cystitis is recognized by the history. Prognosis.—Depends on the cause. Mild forms resulting from pregnancy, specific fevers, or exposure to cold, usually recover in a few weeks. The tuberculous and suppurative varieties are unfavorable. Treatment.—Depends on the cause. Calculous pyelitis will require the treatment indicated for renal calculus. In simple pyelitis keep the patient at rest, restrict the diet to light food, preferably to milk, apply warm poultices locally, use alkaline diluents and some sedative mixture, as the following :— I£ Potass, bromid., Sodii bicarb., aa, gr. clx ; Ext. belladonnae, gr. iv; Ext. buchu, 3j ; Syr. sarsp. comp., q. s. ad f^iv.—M. (Pepper.) Sig.—Tablespoonful three times a day. In pyelitis following cystitis, treat the latter locally, and use stimulating diuretics, like eucalyptus, sandalwood, and copaiba. HYDRONEPHROSIS. Definition.—Dilatation of the pelvis of the kidney, with the accumulation of a watery fluid, resulting from obstruction. Etiology.—(1) Congenital stricture of the ureter. (2) Im- paction of a calculus in the ureter. (3) Abdominal tumors compressing the ureter. (4) Tumors growing within the urinary passages. (5) An inflammatory stricture of the ureter or urethra. Pathology.—The pelvis reveals all grades of distention. In extreme cases it may contain several quarts of fluid, which is at first urinous, but later thin and watery. There is more or less atrophy of the renal tissue. Symptoms.—Slight distention yields no symptoms. In other cases a tumor slowly develops in the region of the affected kidney. On palpation it is elastic, and perhaps FLOATING KIDNEY. 107 fluctuating; on percussion, dull; and on aspiration it yields a clear fluid, which usually contains urea and uric acid. Diagnosis.—This will be based on the history, the exclu- sion of other abdominal enlargements, and the chemical analysis of the fluid obtained by aspiration. Prognosis.—Usually unfavorable. Wrhen it is unilateral, and the other kidney secretes a normal amount of urine, con- taining a normal amount of urea, the prognosis is guardedly favorable. Treatment.—When the distention is moderate the treat- ment is expectant. Wrhen the sac is large, aspirate; and if re-accumulation is rapid, establish a renal fistula or remove the organ. FLOATING KIDNEY. (Movable Kidney.) Definition.—A distinctly mobile condition of the kidney, dependent upon a relaxation of the tissues which surround it. Etiology.—(1) Female sex. (2) Middle life. (3) Rapid emaciation leading to the absorption of the perinephritic fat. (4) A congenital relaxed condition of the perinephritic tissues. (5) Muscular exertion. (6) Repeated pregnancies. Symptoms.—The right kidney is the one usually affected, probably from »its relation to the liver, which moves during the respiratory acts. The kidney may be found in any part of the abdomen, as a movable tumor, reniform in shape, somewhat tender to the touch, and rarely imparting the pulsa- tion of the renal artery. There may be no subjective symptoms, but a sense of un- easiness and attacks of neuralgic pain are often noted. At times the kidney may become swollen and very tender, pro- bably from twisting of the renal vessels inducing engorgement of the organ. Emotional disturbances are often excited by the condition. Diagnosis.—The reniform shape of the tumor, its free mobility, its stationary size, the lessened resistance on percus- sion over the renal region of the affected side, and the absence 108 DISEASES OF THE KIDNEYS. of cachexia will serve to diagnose a floating kidney from other abdominal tumors. * ., Treatment.—In many cases, a regulated diet, the avoid- ance of undue exertion, and the use of a broad binder applied firmly to the abdomen will be the only treatment required. When the symptoms persist the kidney may be stitched in its normal place (nephrorrhaphy); and if this treatment fails the offending organ may be removed (nephrectomy). DISEASES OF THE BLOOD. THE BLOOD. In health the blood amounts to about one-thirteenth of the body-weight. Normal blood contains approximately 5,000,000 red corpuscles, and from 5000 to 15,000 white corpuscles in the cubic millimetre, the ratio of the latter to the red corpuscles being variously estimated as 1 to 300 or 1 to 700. OLIGOCYTHEMIA. Oligocythaemia, or a diminution in the number of red corpus- cles, occurs in all forms of anaemia, but is especially marked in pernicious anaemia, where the number may fall as low as 400,000 to the cubic millimetre. LEUCOCYTOSIS. Leukocytosis is a temporary increase in the number of white blood-corpuscles. It occurs physiologically during the digestion of proteids and fats, after massage, after cold bathing, and in pregnancy; and pathologically in inflammations of serous mem- branes, in certain infections, like pneumonia, diphtheria, and erysipelas, and in cancerous cachexia. POIKILOCYTOSIS. Poikilocvtosis, or a condition in which the red corpuscles are irregular in shape, may occur in any form of severe anae- mia, but is especially marked in pernicious anaemia. (109) 110 DISEASES OF THE BLOOD. Fig. 7. Poikilo-, macro-, microcytosls (as represented by the letters d, 6, c). a, normal blood- corpuscles ; e, product of decomposition of a red blood-corpuscle ; /, nucleated red blood- corpuscle (marked anaemia). MICROCYTOSIS AND MACROCYTOSIS. Microcytosis and macrocytosis are conditions in which the red corpuscles are respectively diminished and increased in size. They may occur in any form of severe anaemia, but are especially marked in pernicious anaemia. DIMINISHED HEMOGLOBIN. The diminution of haemoglobin is usually proportionate to the diminution of the red corpuscles, but there are two marked exceptions, namely, in chlorosis, in which the red corpuscles may be diminished only twenty or thirty per cent., while the haemoglobin is diminished fifty or sixty per cent., and in per- nicious anaemia, in which the red corpuscles are greatly dimin- ished, but are relatively rich in haemoglobin. MELANEMIA. Melanaemia, the presence in the blood of free pigment, usu- ally results from chronic malarial infection. In rare instances it has been found associated with melano-sarcoma and Addi- son's disease. ANEMIA. Ill LIPEMIA. Lipaemia, the presence in the blood of fine drops of fat, may be noted in health. It is also observed in alcoholism, chyluria, and especially in diabetes. MICROORGANISMS IN THE BLOOD. The following microorganisms have been detected in the blood: The plasmodium malariae, the filaria sanguinis hominis, the distoma haematobium, the spirillum of relapsing fever, and the bacillus of anthrax, glanders, typhoid fever, and tuberculosis. ANEMIA. Definition.—A condition in which the blood is diminished in quantity, or is deficient in one or more of its constituents. Varieties.—(1) Symptomatic or secondary anaemia. (2) Essential or primary anaemia. Symptomatic Anaemia. Etiology.—(1) Congenital—a constitutional tendency. (2) Bad hygiene—excesses, faulty diet, impure air, lack of sun- light. (3) Hemorrhage. (4) Organic disease—cancer, Bright's disease, phthisis. (5) Toxic agents—lead, malaria, syphilis. Pathology.—The blood is deficient in haemoglobin and corpuscles, and the tissues show fatty degeneration. Symptoms. General Symptoms.—Pallor of skin and mucous membranes, loss of flesh and strength, and, in severe cases, febrile paroxysms and ecchymoses. Circulation.—A full, soft, and rapid pulse, pulsation of the cervical vessels, palpitation of the heart, haemic murmurs, and slight dropsy beginning in the feet. Respiration.—Hurried breathing.' Digestion is weak. Nervous System.—Headache, vertigo, disturbed sleep, neu- ralgic pains, and a tendency to syncope. 112 diseases of the blood. Diagnosis.—Usually evident, but appearances are decep- tive, and an absolute diagnosis rests on the examination of the blood. Prognosis.—Depends on the cause. Treatment.—Removal of the cause, when possible. Good hygiene. The use of iron, arsenic, and general tonics. Essential, or Primary Anaemia. Definition.—Anaemia not dependent upon any other dis- ease, and arising without obvious cause. Varieties.—(1) Pernicious anaemia. (2) Chlorosis. PERNICIOUS ANEMIA. (Idiopathic Anaemia, Progressive Pernicious Anaemia.) Definition.—A grave form of anaemia, often unassociated with any distinct causal lesions. Etiology. — Male sex, middle life, parturition, and symptomatic anaemia, from its various causes, predispose to it. Pathology.—As a result of the disease the organs reveal fatty degeneration. Not infrequently atrophy of the gastric tubules is found as an adequate cause. Often an excessive amount of iron pigment is found in the liver and other organs, indicating increased destruction of red corpuscles. In some cases changes in the bone-marrow have been detected ; in others, degeneration of the sympathetic ganglia and of the posterior columns of the spinal cord; but these conditions are probably secondary. Symptoms.—The general symptoms of intense anaemia, with the following peculiar symptoms : A lemon-yellow colored skin ; febrile paroxysms, little wasting, and often an increase in weight; frequently gastric disturbance and retinal hemorrhage. The Blood.—The red corpuscles are extremely reduced in number, sometimes 80 or 90 per cent.; the haemoglobin is dimin- ished, but not proportionately ; the red corpuscles are of various shapes and sizes, some small (microcy tes), some large (macrocy tes), CHLOROSIS. 113 some very large and nucleated (gigantoblasts), and many irreg- ular in outline (poikilocytes). The number of white corpuscles is not materially changed. Prognosis.—Very unfavorable, the average duration being one to two years. Recovery occasionally occurs. Treatment.—Removal of any obvious cause. Good hy- gienic conditions; a nutritious and easily assimilable diet; rest; the use of iron and arsenic, especially the latter, gradu- ally increased to its physiological limit. CHLOROSIS. (Green Sickness, Primary Anaemia.) Etiology.—Puberty, girls, rarely boys; bad hygiene, i. e. poor food, impure air, overwork, and lack of sunlight. Pathology.—Generally, no demonstrable causal lesions. In persistent cases, imperfect development of the large arteries and of the genitalia is sometimes found. Symptoms.—General manifestations of anaemia, with the following peculiar symptoms: The blood shows a moderate reduction of the number of red corpuscles, with a much greater reduction of the haemoglobin, and some irregularity in the size and shape of the corpuscles; a pale-green tint to the skin, and a tendency to hysterical outbreaks and to menstrual disorders. These conditions, with the age and sex of the patient, deter- mine the diagnosis. Complications. — Gastric ulcer, phthisis, exophthalmic goitre, and amenorrhoea. Prognosis.—Favorable. Treatment.—Good hygienic conditions; nutritious food ; iron in ascending doses, with the occasional use of some saline laxative. fy Ferri sulph. ex., Potass, carb., aa gr. xxxvj.—M. Ft. in pil. No. xxiv. Sig.—Three pills daily, increased to nine pills daily. 8 114 diseases of the blood. LEUCOCYTHEMIA. (Leucaemia.) Definition.—A disease characterized by a great excess of the white corpuscles, with hyperplasia of the spleen or of the lymphatics, or changes in the bone-marrow. Etiology.—The causes are obscure. Male sex, middle life, malaria, heredity, bad hygiene, and repeated hemorrhages are predisposing factors. It is probably an infectious disease. Pathology.—Three varieties are noted : (1) Splenic leu- caemia, in which the spleen is enlarged from congestion and hyperplasia. (2) Lymphatic leucaemia, in which the lymphatic glands are the seat of hyperplasia. (3) Myelogenic leucaemia, in which the medulla, especially of the ribs, sternum, and verte- brae, is converted into a pulpy material, ranging from a dirty yellow to a deep red color, according as the congestion or the excess of leucocytes predominates. Leucaemic tumors (collections of proliferated leucocytes) are frequently found in the various organs. The liver is often considerably enlarged. The tissues show fatty degeneration. Symptoms.—The general manifestations of anaemia, with the following peculiar symptoms: Enlargement of the lym- phatics or spleen, or tenderness over the bones, slight febrile paroxysms, dimness of vision from hemorrhagic retinitis or leucaemic deposits. The Blood.—A marked and persistent actual increase of the white corpuscles. The proportion may be 1 to 50 or even 1 to 10. The white cells vary in size and often lack amoeboid move- ment. Octahedral crystals, discovered by Charcot, are often found. The red corpuscles are somewhat diminished in number. Prognosis.—Recovery rarely follows. Death usually re- sults in from one to three years. Treatment.—Good hygienic conditions. The use of iron, quinine, and arsenic. Removal of*the spleen has given nega- tive results. addison's disease. 115 PSEUDO-LEUCEMIA. (Hodgkins' Disease, Lymphatic Anaemia, Malignant Lymphoma.) Definition.—A disease characterized by a hyperplasia of the lymphatic structures and by progressive anaemia, without any increase of the white corpuscles. Etiology.—The causes are obscure. Male sex, early life, and simple adenitis seem to be predisposing causes. It is prob- ably of infectious origin. Pathology.—There is hyperplasia of the lymphatic struc- tures ; glands, spleen, and bone-marrow sharing in the process. New foci of lymphatic tissue are often noted. Symptoms.—The general manifestations of anaemia, with the following peculiar symptoms: Enlargement of the lym- phatic glands, which usually begins in the neck; the glands are painless and at first distinct and freely movable, but later they fuse and form firm nodular masses. The spleen is gen- erally somewhat enlarged. Febrile paroxysms are common. Diagnosis.—Tuberculous adenitis may resemble pseudo- leukemia, but the former is more common in children, is more apt to affect the submaxillary glands, and is generally followed by caseation and suppuration of the glands. Prognosis.—Very unfavorable. Treatment.—The same as for leucaemia. ADDISON'S DISEASE. Definition.—A constitutional disease, characterized ana- tomically by a degeneration of the suprarenal capsules or semilunar ganglia, and clinically by pigmentation of the skin, anaemia, and prostration. Etiology.—Male sex, middle life, and laborious work are predisposing factors. Pathology.—In most instances tuberculosis of the supra- renal capsules is discovered. Other affections, such as tumors and degeneration of the suprarenal capsules, may produce the disease. In a few instances degenerative changes in the 116 diseases of the blood. abdominal sympathetic ganglia have been the only discoverable lesions. Symptoms.—Moderate anaemia, with bronzing of the skin and mucous membranes, great weakness, and gastric irritability are its chief manifestations. Prognosis.—Unfavorable. Duration is one to two years. Treatment.—Rest and nutritious diet, with iron, arsenic, quinine, and strychnia. HEMOPHILIA. (Bleeder's Disease, Hemorrhagic Diathesis.) Definition.—An hereditary disease, characterized by a tendency to bleed excessively from slight wounds, or even spontaneously. Etiology.—The great cause is heredity. It is more com- mon in males, but is usually transmitted by females, even by those who are not themselves afflicted. Pathology.—Unknown. In some instances the arteries have been found smaller than normal, with their walls thin and degenerated. Symptoms. — The chief symptom is free and persistent bleeding after trivial injury. Spontaneous hemorrhages from mucous membranes of the nose, stomach, bowel, etc., and sub- cutaneous extravasations are quite common. The only other symptom is a peculiar inflammation of the joints, resembling rheumatism. Prognosis.—Unfavorable. Grandidier states that one-half die before the eighth year, and less than one-eighth survive their twenty-first. In some instances the tendency is out- grown. Treatment.—Protective and palliative. For the bleeding apply cold compresses and styptics, and use internally ergot, hamamelis, or erigeron. The resulting anaemia will be bene- fited by iron. PURPURA HEMORRHAGICA. 117 SCURVY. (Scorbutus.) Etiology.—Lack of fresh vegetables and bad hygienic surroundings are the predisposing causes. Pathology. — The pathogenesis of scurvy is unknown. Fatty degeneration from the anaemia, and widespread ecchy- moses are found after death. Symptoms.—The general manifestations of anaemia, with great weakness; spongy, bleeding gums, fetor of the breath, and loosening of the teeth ; subcutaneous ecchymoses, and hemorrhages from the mucous membranes ; and finally, a pain- ful, brawny induration of the muscles due to a sanguineous exudation. Prognosis.—Favorable in its earlier stages. Treatment.—Fresh vegetables and the free use of lemon- juice. Iron in moderate doses. Weak solutions of chlorate of potassium, or nitrate of silver may be applied to the bleeding gums. PURPURA HEMORRHAGICA. (Morbus Maculosus Werlhofii.) Definition.—A condition arising without obvious cause, and characterized by extravasation of blood in the skin and bleeding from the mucous membranes. Etiology.—Bad hygiene, early life, and female sex exert some predisposing influence; but it may occur at any age and in the most robust of either sex. A microorganismal cause has been suggested. Pathology.—Unknown. Symptoms. — The onset may be marked by some fever, headache, malaise, and pain in the limbs; but these symptoms may be absent, and the disease ushered in with a copious crop of small hemorrhages into the skin, followed by bleeding from the mucous membranes. Anaemia and its associated phenomena develop in severe cases. 118 DISEASES OF THE BLOOD. Diagnosis.—The absence of high fever and nervous symp- toms will separate it from typhus fever and cerebro-spinal meningitis. The history and the absence of spongy gums and of brawny induration of the muscles will separate it from scurvy. Previous health and the absence of hereditary ten- dency separate it from hwmophilia. Prognosis.—Depends on the severity. Mild cases recover in from one to two weeks; severe cases may prove fatal in a few days from exhaustion or hemorrhage into the brain. Re- lapses are common. Treatment. — Rest. Light, nutritious food. Arsenic, iron, turpentine, and the fluid extract of hamamelis are the most serviceable remedies. DISEASES CIRCULATORY SYSTEM. INSPECTION. Inspection detects the apex-beat, and determines its position, force, and extent; any abnormal centres of pulsation ; and any unnatural prominence over the praecordial region. The Apex-beat. The normal position of the apex-beat is in the fifth inter- costal space, about an inch within the mammary line (a line drawn from the middle of the clavicle parallel with the sternum). The beat is usually detected by inspection or pal- pation, but when these methods fail it may be localized by auscultation, the point in the region of the apex where the first sound is heard with maximum intensity corresponding to the beat. The Effect of Respiration and Position on the Apex-beat— The location and force of the apex-beat are modified by the posture of the patient and the stage of the respiratory act. In the recumbent position the apex-beat may be elevated an inch or more, and when the body is inclined to the left, the heart being a more or less movable organ, the beat may be detected in the mammary line, or even some distance to its outer side. During forced inspiration the beat may become imper- ceptible, or if such is not the case it may be found some distance below its usual place, on account of the upward 120 DISEASES OF THE CIRCULATORY SYSTEM. movement of the ribs in the inspiratory act. During forced expiration, the air being driven from the lung-tissue in front of the heart, the beat becomes more forcible, and its position elevated on account of the descent of the ribs which occurs in expiration. In view of the influence exerted by respiration and position on the apex-beat the patient, as a rule, should be examined in the erect or sitting posture, while breathing quietly. Displacement of the Apex-heat. Displacement to the left may result from :— 1. Hypertrophy and dilatation of the heart (down and to the left.) 2. Pericardial effusion (up and to the left). 3. Chronic diseases of the left lung and pleura, associated with retraction—as fibroid phthisis and pleural adhesions. 4. Abdominal tumors and effusions (up and to the left). 5. The pressure of a pleural effusion on the right side (up and to the left). Displacement to the right may be caused by :— 1. Chronic disease of the right lung or pleura associated with retraction. 2. Pressure of a pleural effusion on the left side. Displacement downward may result from :— 1. Hypertrophy and dilatation of the heart, chiefly the left ventricle. 2. Pressure of solid growths in the upper mediastinum. 3. Aneurism of the aortic arch. 4. Enlargement of the liver, causing traction through the central tendon of the diaphragm. (Paul.) Deformity of the chest may cause displacement in any direction. Changes in Force and Extent of the Apex-beat. The force and extent may be increased by :— 1. Hypertrophy of the heart. INSPECTION. 121 2. Excited action of the heart, from drugs, reflex irritation, excitement, or diseases, as exophthalmic goitre. 3. Shrinking of the lungs, as in phthisis. A weak apex-beat may be noted in :— 1. Healthy people. 2. Degeneration or dilatation of the heart. 3. Pericardial effusion. 4. Emphysema. 5. Shock or collapse. Abnormal Centres of Pulsation. Epigastric pulsation may result from :— 1. Excited action of the heart from any cause. 2. Enlargement of the right ventricle. 3. A pulsating aorta noted in certain nervous and anaemic patients. 4. Aortic aneurism. 5. Tumors of the left lobe of the liver resting on the aorta. Pulsation at the base of the heart may result from :— 1. Aneurism of the aortic arch. 2. Cardiac hypertrophy. 3. Shrinking of the lungs, as in phthisis. Pulsation in the left axillary region may result from :— 1. Enlargement of the heart. 2. A tense purulent effusion in the left pleural sac (pulsat- ing empyema). 3. Aneurism. 4. Chronic diseases of the left lung and pleura, associated with retraction. Unnatural pulsation in the carotids may result from :— 1. Excitement of the heart from any cause. 2. Exophthalmic goitre. 3. Anaemia. 4. Valvular disease, especially aortic regurgitation. 5. Aneurism or dilatation of the vessels. 6. Unnatural elasticity of the vessels, noted in certain ner- vous and anaemic patients. 122 DISEASES OF THE CIRCULATORY SYSTEM. Jugular Pulsation. The jugular vein often becomes distended in forced expira- tion and coughing. Distention of the jugular vein is some- times noted in adherent pericardium. A true, rhythmical venous pulsation usually results from tricuspid regurgitation. A pulsation may be transmitted to the jugular vein from the underlying carotid, but this false pulsation will still continue when light pressure is made on the vein at the root of the neck, while the true venous pulse will cease. Precordial Prominence. Unnatural prominence of the prcecordia may result from :— 1. Deformity. 2. Enlargement of the heart. 3. Pericardial effusion. PALPATION. This not only determines the position, force, extent, and rhythm of the apex-beat, but also detects the existence of any fremitus or thrill. A thrill is a vibratory sensation likened to that received when the hand is placed on the back of a purring cat. Thrills at the base of the heart may result from valvular lesions, athe- roma of the aorta, aneurism, and from roughened pericardial surfaces, as in pericarditis. A presystolic thrill at the apex is almost pathognomonic of mitral stenosis. PERCUSSION. This determines the shape and extent of the cardiac dulness. The normal area of superficial or absolute percussion-did ness (the part uncovered by lung) is detected by light percussion, and extends from the fourth left costo-sternal junction to the AUSCULTATION. 123 apex-beat; from the apex-beat to the junction of the xiphoid cartilage with the sternum and thence up the left border of the sternum. The normal area of deep percussion-dulness (the heart pro- jected on the chest-wall) is detected by firm percussion, and extends from the third left costo-sternal articulation to the apex-beat; from the apex-beat to the junction of the xiphoid cartilage with the sternum; and thence up the right border of the sternum to the third rib. The lower level of the cardiac dul- ness fuses with the liver dulness, and can rarely be determined. The area of cardiac dulness is increased in : (1) Hypertrophy and dilatation of the heart. (2) Pericardial effusion. It is apparently increased in shrinking of the lungs, as in phthisis. The area of cardiac dulness is diminished in : (1) Emphy- sema. (2) Pneumothorax. (3) Pneumopericardium (rare). (4) Gaseous distention of the stomach. AUSCULTATION. This determines the quality, intensity, and rhythm of the heart-sounds, and detects the presence of any adventitious sounds, as murmurs. The two sounds heard over the heart have been represented by the syllables, " lubb, tup." The first sound (systolic) results from contraction of the ventricle, tension of the auriculo-ventricular valves, and the impact of the heart against the chest-wall, and is synchronous with the apex-beat and carotid pulse. This sound is prolonged and dull. After the first sound there is a short pause, and then follows the second sound (diastolic), which results from the closure of the aortic and pulmonary valves. This sound is short and high- pitched. After the second sound a longer pause follows be- fore the first is again heard. The Intensity of the Heart-sounds. Both sounds are accentuated in : (1) Excitement of the heart from any cause. (2) Anaemia. (3) Cardiac hypertrophy. (4) Subjects with thin chest-walls. (5) Consolidation of the lung, as in phthisis and pneumonia. 124 DISEASES OF THE CIRCULATORY SYSTEM. Accentuation of the aortic second sound results from : (1) Hy- pertrophy of the left ventricle. (2) High arterial tension, as in arterio-sclerosis and Bright's disease. (3) Aortic aneurism. Accentuation of the pulmonary second sound results from : (1) Pulmonary obstruction, as in emphysema, pneumonia, and the congestion of the lungs following mitral disease. (2) Hy- pertrophy of the right ventricle. Weakness of both sounds is noted in : (1) General obesity. (2) General debility. (3) Degeneration or dilatation of the heart. (4) Pericardial or pleural effusion. (5) Emphysema. Reduplication of the Heart-sounds. This is probably due to a lack of synchronous action in the valves of the two sides of the heart, and results from many con- ditions, but notably from increased resistance in the systemic or the pulmonary circulation, as in arterio-sclerosis of chronic nephritis and in emphysema. It is frequently noted in mitral stenosis and pericarditis. Adventitious Sounds or Murmurs. A murmur is an abnormal sound heard over the heart or bloodvessels, and may result from : (1) Obstruction or regur- gitation at the valves following endocarditis. (2) Dilatation of the ventricle or relaxation of its walls, rendering the valves relatively insufficient. (3) Aneurism. (4) A change in the blood constituents, as in anaemia. (5) Roughening of the pericardial surfaces,- as in pericarditis. (6) Irregular action of the heart. Murmurs produced within the heart are termed endocardial; those produced outside, exocardial; those produced in aneu- risms, bruits; and those produced by anaemia, haemic murmurs. Haemic Murmurs. Haemic murmurs have the following characteristics : They are soft and blowing in character, usually systolic in time, heard best over the pulmonary valves, transmitted into the THE PULSE. 125 carotids, accompanied with a hum in the veins of the neck, associated with the symptoms of anaemia, and disappear with the latter. Pericardial Friction-sounds. Pericardial murmurs, or friction-sounds, are superficial, rough and creaking in quality, to and fro in time, not trans- mitted beyond the praecordia, and may be modified by pressure of the stethoscope. The Aneurismal Murmur, or Bruit. This is usually loud and booming in character, systolic in time, heard best over the aorta or base of the heart, and is often associated with an abnormal area of dulness and pulsa- tion, and with symptoms resulting from pressure on neighbor- ing structures. THE PULSE. The average frequency of the pulse in the adult is between 70 and 80 per minute At birth it is between 130 and 150; in the second year about 100, and so it gradually lessens as the child grows old. Increased frequency of the Pulse (Tachycardia). Habitual frequency is sometimes noted in health. The frequency may be temporarily increased by erect posture, ex- citement, eating, and the use of stimulants. Abnormal frequency may result from—(1) Pyrexia. The pulse usually bears a definite relation to the temperature, but in certain diseases, as scarlet fever and septicaemia, it is dispro- portionately rapid. (2) Exophthalmic goitre. (3) Organic heart-disease. (4) Pressure at the base of the brain sufficient to paralyze the pneumogastrics, as in clot, tumor, and advanced meningitis. (5) Shock. (6) Reflex irritation, as in dyspepsia, ovarian, or uterine disease. (7) An independent paroxysmal neurosis ("Essential Paroxysmal Tachycardia"). (8) Certain drugs—belladonna, nitrites, alcohol, etc. (9) Rheumatoid ar- thritis (Sansom). 126 DISEASES OF THE CIRCULATORY SYSTEM. Infrequency of the Pulse (Bradycardia). Physiological slowness is noted in repose, fasting, the puer- perium, old age, and habitually in certain people (40 to 60 per minute). Pathological infrequency is observed in many conditions, notably—(1) In organic heart disease, especially fatty degen- eration and fibroid induration. (2) In jaundice. (3) From pressure at the base of brain sufficient to irritate the vagus, as in beginning meningitis. (4) At the close of febrile dis- eases, as typhoid fever, pneumonia, etc. (5) After the use of certain drugs, as digitalis, aconite, opium, etc. Irregular Rhythm. (Arhythmia.) The Intermittent Pulse___This per se is not significant of any pathological condition. It is habitually noted in certain people, after exercise, eating, excitement, or the use of tobacco, tea, or coffee. It is frequently reflex from gastric, hepatic, uterine, or renal disease. It is common in lithaemia and fatty degeneration of the heart. There may be a false intermission or infrequency in the radial pulse when the heart fails to transmit all its beats to the wrist. This condition is usually indicative of a weak heart. The Irregular Pulse—This has the same significance as the intermittent pulse. It is also very common in myocarditis and valvular disease, especially mitral regurgitation. Fig. 8. Sphygmogram of the trigeminal pulse. The Bigeminal and Trigeminal Pulses.—Two or three regular beats followed by a longer pause. They have the same significance as the irregular pulse. THE PULSE. 127 The Pulsus Paradoxus.—One which is more or less sup- pressed at the close of each full inspiration. It is thought to be due to the compression of the great vessels by inflammatory adhesions, the latter being stretched during the act of inspira- tion. It is frequently noted in adherent pericardium. The Dicrotic Pulse.—A pulse in which the main beat is quickly followed by a secondary wave or slight rebound of the vessel. The secondary or dicrotic wave results from a Fig. 9. Sphygmogram of a dicrotic pulse. recoil of the relaxed vessels after the latter have been dis- tended by a sharp ventricular contraction. It is indicative of low arterial tension, and is noted especially in febrile diseases and low states of the nervous system. Other Variations in the Pulse. The High-tension Pulse.—One in which the force of the beat is relatively increased. The tension may be roughly estimated by noting the amount of pressure of the fingers that is required to arrest the beat. A high-tension pulse is observed in many conditions, notably in cardiac hypertrophy, excitement of the heart, chronic ne- phritis ; in cerebral affections irritating the vaso-motor centre, such as apoplexy, tumors, and beginning meningitis; after the use of certain drugs, as digitalis, ergot, and alcoholic stimulants; in chills; in pregnancy; in certain neuroses, as angina pectoris, epileptic and hysterical seizures ; and from contraction of the capillaries by irritants generated in the body, as in lithaemia, gout, uraemia. 128 DISEASES OF THE CIRCULATORY SYSTEM. The Low-tension Pulse.—This is also observed in many conditions, notably in degeneration of the heart, in collapse, in debility, in fevers, and in low states of the nervous system. Venous Pulse.—A true jugular pulsation is often noted in tricuspid regurgitation. A venous pulse in the dorsum of the hand may be due to (1) forcible propulsion of blood through the capillaries, as in aortic regurgitation with great hyper- trophy of the left ventricle; or (2) to extreme relaxation of the arterioles and capillaries, permitting the transmission of the pulse-wave, as in grave cachexia and anaemia. Asymmetrical Radial Pulses.—May result from: (1) Anomalies in the distribution, size, and division of one of the vessels. (2) Aortic aneurism. (3) An embolism or an atheromatous plate within the vessel. (4) Fractures, luxations, or inflammatory exudations causing compression of the vessel. (5) Compression of one vessel by tumors within or without the thorax. " Water-hammer Pulse " (Corrigan's Pulse).—Characterized by a short, powerful beat, which suddenly collapses. The peculiar pulsation may be distinctly visible, not only in the carotids but throughout the brachial artery. This pulse is diagnostic of aortic regurgitation during the period of compen- sation, and its force is due to the excessive ventricular hyper- trophy and to the large amount of blood expelled with each systole; its sudden recession is due to the incompetent valves failing to support the column of- blood. PALPITATION. Definition.—A rapid and tumultuous action of the heart perceptible to the patient. Rapidity not perceptible to the patient is not termed palpitation. Etiology.—It may result from : (1) Reflex irritation, as from gas or acid in 'the stomach. (2) Excitement, mental or physical. (3) Organic heart disease. (4) Exophthalmic goitre. (5) Over-work, as in the " irritable heart" of un- trained recruits. (6) Anaemia. (7) Hysteria. (8) An inde- pendent neurosis (Essential Paroxysmal Tachycardia). DROPSY—GENERAL CYANOSIS. 129 DROPSY. Definition.—An unnatural collection of serous fluid in the tissues or cavities of the body. Etiology.—Dropsy results from : (1) Venous stasis, from chronic heart, liver, and lung diseases, and from local obstruc- tion to the venous circulation by tumors, pregnant uteri, or varicose conditions. The last is a common cause of oedema in the legs of old people. (2) Alterations in the blood or capillaries, as in Bright's disease, anaemia, and inflammation. Cardiac dropsy usually begins in the feet and ascends. GENERAL CYANOSIS. Definition.—Blueness of the surface from insufficient oxi- dation of the blood. Etiology.—Cyanosis results from : (1) Conditions which obstruct the entrance of air, as croup ; oedema of the larynx ; tumors or foreign bodies in the air-passages; tumors pressing on the air-passages; emphysema; pneumonia; pleurisy; paralysis of the respiratory muscles, as in bulbar palsy; and spasm of the respiratory muscles, as in epilepsy, tetanus, etc. (2) An inability to get blood to the air, as in all forms of chronic heart disease ending in pulmonary congestion. Congenital Cyanosis is usually associated with stenosis of the pulmonary orifice, an imperfect ventricular septum, or a patulous foramen ovale; it probably results not so much from direct mixture of venous and arterial blood, as from the failure of the blood to reach the lung, or from general venous congestion. 9 130 DISEASES OF THE CIRCULATORY SYSTEM. PERICARDITIS. Definition. — An inflammation of the pericardium, or serous covering of the heart. Etiology.—(1) Idiopathic, from exposure. (2) Traumatic. (3) Secondary to neighboring inflammations, as pleurisy, phthisis, pneumonia, mediastinal disease. (4) Secondary to some general disease, as rheumatism, Bright's disease, septi- caemia, tuberculosis, aud the eruptive fevers. Pathology.—In the early stage the membrane is red, sticky and lustreless; and if the process now ceases, the con- dition is termed dry pericarditis. If, however, the inflammation continues, an exudate is formed which may be: (1) Sero-fibrinous, (2) fibrinous, or (3) purulent. In the sero-fibrinous form there is little lymph, the exudate being mainly composed of straw-colored serum (a few ounces to several pints), which in favorable cases is gradually absorbed. In the fibrinous form, serum is scant and the membrane is covered with a butter-like exudate, which subsequently or- ganizes and unites more or less closely the pericardial surfaces, causing adherent pericardium. The adhesions offer resistance to the ventricular contractions and ultimately induce cardiac hypertrophy. In rare instances the fibrinous exudate becomes calcified. In the purulent form, death usually results; but evacua- tion of the pus.may be followed by union of the pericardial surfaces, and ultimate recovery. Symptoms.—Moderate fever, praecordial pain and tender- ness, dry cough, dyspnoea, and palpitation. The pulse is at first rapid and forcible, but later weak and irregular. Physical Signs. First Stage.—Dry pericarditis. Inspection.—Negative. Palpation.—Sometimes a fremitus, from the grating of the roughened pericardial surfaces. Percussion.—Negative. PERICARDITIS. 131 Auscultation—A superficial to-and-fro friction-sound, usu- ally heard best at the base of the heart and not transmitted, to any extent, beyond the praecordia. Second JStage.—Sero-fibrinous effusion. Inspection.—Bulging of the praecordia. Palpation.—The apex-beat is feeble or lost. If detected, it is pushed upwards and to the left. Percussion.—Increased area of dulness, triangular in shape with the base down. Auscultation.—The heart-sounds are muffled, feeble, and distant. Purulent effusion yields similar signs, but in addition,— (1) the symptoms of hectic fever, viz: high and irregular fever, sweats, chills, and progressive pallor. (2) Sometimes oedema over the praecordia; and, (3) in doubtful cases, the aspirating needle reveals pus. Fibrinous pericarditis (Adherent pericardium) is often diffi- cult to recognize, and while the following signs suggest the condition, they are not absolutely diagnostic :— Praecordial bulging, a weak apex-beat with loud sounds, a systolic retraction or dimpling not only at the apex, but over a large part of the praecordia, a peculiar diastolic collapse of the jugular veins (Friedreich), a feeble apex-beat, with a forcible impulse over the body of the heart (Paul). With these signs there are often symptoms of heart-failure, such as dyspnoea, dropsy, and cyanosis. Diagnosis. Acute Endocarditis.—The murmur is soft and blowing, not harsh ; it is usually single, not to-and-fro; it is somewhat distant, not superficial; it is not necessarily heard best at the base, but at one of the valve points; it is not con- fined to the praecordia, but is usually transmitted; and it is not followed by the signs of effusion. Pericardial effusion must be distinguished from cardiac hy- pertrophy. In hypertrophy the area of dulness is increased, but normal in outline; the apex-beat is displaced downwards and to the left, and is forcible; and the sounds are loud and clear. Pericardial effusion and cardiac dilatation.—In dilatation there is no friction-sound ; the apex is usually displaced down- 132 DISEASES OF THE CIRCULATORY SYSTEM. wards, never upwards; the area of dulness is not pyramidal, but extends laterally; the sounds are not muffled, but clear and sharp. Prognosis.—In the dry and sero-fibrinous forms the prog- nosis is good under favorable conditions. In the purulent form the outlook is extremely grave. The fibrinous form, though not immediately fatal, is very serious on account of the secondary changes which it induces in the cardiac muscle. Treatment.—Absolute rest. Light diet. Opium is usu- ally required to insure quiet and to relieve pain. When the action of the heart is rapid and irregular, either aconite or digitalis may be administered according to the strength of the pulse. Local Treatment.—In severe cases apply a few wet cups, leeches, or a blister to the praecordia. In other cases, an ice- bag or poultice may give relief. Pericardial effusion (Chronic pericarditis).—When the effu- sion is decided, apply small blisters over the praecordia, admin- ister iodide of potassium (gr. x thrice daily), and encourage diuresis with digitalis or caffeine, and catharsis with saline draughts. (1) When the effusion is very large, (2) when it creates much disturbance, as dyspnoea, cyanosis, and the like, (3) when its absorption cannot be accomplished by internal reme- dies, or (4) when it is purulent, paracentesis of the peri- cardium is indicated. The needle should be introduced in the fifth interspace, a little to the right of the point of the normal apex-beat. When the effusion is purulent, a free incision offers a slight, and the only chance of cure. In adherent pericardium, repeated small blisters may be employed and heart-failure should be combated with digitalis and similar cardiac tonics. OTHER AFFECTIONS OF THE PERICARDIUM. Hydropericardium (Dropsy of the pericardium) results from pericarditis, or from one of the causes of general dropsy, as chronic heart, kidney, or lung disease. Physical Signs.—The same as sero-fibrinous pericarditis. ENDOCARDITIS. 133 Hsemopericardium (Blood in the pericardial sac) results from the rupture of an aneurism, rupture of the heart, trau- matism, and cancerous and tuberculous pericarditis. Physical Signs.—The same as hydropericardium. It is speedily fatal. Pneumopericardium (Air in the pericardium).—This rare condition results from external wounds, or the rupture of an air-containing organ into the pericardium, as the perforation of a pyo-pueumothorax into the pericardial sac. The entrance of a septic irritant produces pus and the condition becomes a pneumo-pyopericardium. Physical Signs.—Percussion over the praecordia yields tympany ; and auscultation, splashing and metallic sounds. ENDOCARDITIS. (Valvulitis.) Definition.—Inflammation of the lining membrane of the heart. The process is usually confined to the valves. Varieties.—(1) Exudative, or vegetative endocarditis (Endocarditis verrucosa). This begins as an acute affection, but usually leads to chronic interstitial valvulitis. (2) Sclerotic, or interstitial valvulitis (Chronic endocarditis). (3) Ulcerative, or malignant endocarditis. Etiology.—Rheumatism is the chief cause. At least 50 to 60 per cent, of all cases of acute rheumatism will be com- plicated with endocarditis. It is more liable to complicate rheumatism in the young than in the old. There is no rela- tion between the severity of the rheumatic disease and the liability to heart complication. The specific fevers, chorea, septicaemia, Bright's disease, syphilis, tuberculosis, alcoholism, and excessive muscular exertion, are also predisposing causes. It may be congenital. It rarely, if ever, results from expo- sure to cold and wet. Pathology.—Post-natal endocarditis most commonly in- volves the valves of the left side of the heart. Pre-natal endocarditis most commonly involves the valves of the right side of the heart. In the exudative form the valve is red, swollen, lustreless, 134 DISEASES OF THE CIRCULATORY SYSTEM. and studded with numerous bead-like vegetations which are especially marked along its free margins. These vegetations are composed of proliferated connective- tissue cells, the superficial layers of which have undergone coagulation-necrosis, and are covered with more or less fibrin derived from the blood. They may be whipped off by the blood-current, and be carried as emboli to distant organs, as the brain, kidney, and spleen ; but more commonly, if life is preserved, they are partially absorbed, and the remaining proliferated connective- tissue cells form fibrous tissue, and thus sclerotic valvulitis is secondarily induced. Sclerotic valvulitis may arise as a primary disease, and is characterized by thickening, curling and puckering of the valve from an overgrowth of fibrous tissue, which is often as- sociated with more or less fatty degeneration of the cells and a deposition of lime salts in their midst. Symptoms of Acute Endocarditis.—Subjective phe- nomena are often absent, and auscultation may furnish the only indication of endocarditis, namely, a prolongation of the heart-sound, which later develops into a distinct murmur. In many cases fever, an irregular and rapid pulse, palpita- tion, praecordial distress, and dyspnoea will be associated symp- toms. Diagnosis.—By signs alone. In pericarditis, the friction- sound is to-and-fro, superficial, perhaps modified by pressure of the stethoscope, not transmitted much beyond the prae- cordia, and is followed by signs of effusion. Prognosis.—In simple endocarditis the prognosis should be guarded. The lesion rarely disappears, and permanent damage to the valve results. Under favorable conditions, however, compensatory hypertrophy of the heart results, and good health may be preserved for an indefinite period. Treatment.—Absolute rest. Treat the causal condition. When the symptoms are marked, apply blisters, mustard poultices, leeches, or ice-bags to the praecordia. Support the system with moderate doses of quinine. When the pulse is weak and irregular, the tincture of digitalis (5 to 10 drops) will be of great value. If the pulse is rapid and CHRONIC VALVULAR AFFECTIONS. 135 strong, aconite may be employed instead of digitalis. Absor- bents like the iodides are of no value. Convalescence should be prolonged and guarded, so that compensatory hypertrophy may result. CHRONIC VALVULAR AFFECTIONS. Period of Compensation.—By compensation is meant an in- crease in the size and strength of certain cardiac chambers sufficient to enable the arterial system to receive its normal amount of blood, notwithstanding obstruction or regurgitation at one or more of the valves. The duration of this period is indefinite, and depends largely on the amount of damage sustained by the heart and the hy- gienic conditions to which the patient is subjected. During perfect compensation, subjective symptoms are absent, and physical signs indicate the disease. Aortic Stenosis, or Aortic Obstruction. Definition.—Obstruction to the flow of blood into the aorta from thickening or adhesion of the aortic segments. Physical Signs. Inspection.—If the heart is strong, the apex-beat is forcible, and is noted downward and to the left. Palpation confirms inspection, and sometimes detects a sys- tolic thrill at the base of the heart. Percussion may yield an increased area of cardiac dulness, especially to the left. Auscultation.—A systolic murmur with maximum intensity in the right second intercostal space, and transmitted into both carotid arteries. Pulse.—During perfect compensation, the pulse is quite normal, but when the heart weakens, it becomes small and slow. Compensation.—From obstruction to the outflow of blood, the left ventricle becomes hypertrophied. Sequence.—Mitral regurgitation. Weakening and dilata- tion of the left ventricle prevents perfect closure of the mitral orifice, and relative insufficiency results. 136 DISEASES OF THE CIRCULATORY SYSTEM. Aortic Insufficiency, or Aortic Regurgitation. Definition.—Failure of the aortic valves to prevent a re- turn of blood to the ventricle, from rupture or inflammatory contraction of the segments, or from dilatation of the orifice. Physical Signs. Inspection.—Apex-beat forcible, and noted far downward and to the left. The praecordia may bulge. Palpation.—Confirms inspection. Percussion.—Increased area of cardiac dulness, especially to the left. Auscultation.—A diastolic murmur with maximum intensity in the right second intercostal space, and transmitted down the sternum and towards the apex. Pulse.—The arteries, especially the carotids, brachials, and radials, pulsate visibly. Palpation detects the " water-hammer," or Corrigan's pulse, i. e., a short, full, and receding pulse. The extreme cardiac enlargement makes the pulse full, and the prompt leakage back into the ventricle makes it short and receding. Elevation of the arm, during palpation of the radial, makes this pulse more apparent, as the position favors regur- gitation. A capillary pulse is sometimes present. It may be noted at the root of the finger-nail by an alternate blushing and paling, synchronous with the heart-beats. Compensation.—Dilatation and hypertrophy of the left ventricle. Dilatation results from the reception of such a large quantity of blood during diastole, and hypertrophy follows from the increased effort which the ventricle must put forth in emptying itself of this extra quantity of blood. This extremely dilated and hypertrophied heart has been called the cor bovinum, or ox-heart. Sequence. — Mitral regurgitation. The dilatation and weakening of the ventricle prevent perfect closure of the mitral orifice, and relative insufficiency results. Mitral Stenosis, or Mitral Obstruction. Definition.—Obstruction to the flow of blood through the mitral orifice, from thickening or adhesion of the mitral segments. CHRONIC VALVULAR AFFECflONS. 137 Physical Signs. Inspection.—Apex-beat is not much displaced. There is sometimes bulging over the lower part of the sternum. Palpation.—A rough presystolic thrill near the apex. Percussion.—Increased area of dulness, especially to the right. Auscultation.—A prolonged, rough, churning murmur, presystolic in time, heard most distinctly a little above and to the left of the apex, and not transmitted. The second sound at the pulmonary cartilage is accentuated from the enlargement of the right ventricle. Pulse.—During the period of compensation the pulse is small and regular. Compensation.—From obstruction to the outflow of blood the left auricle becomes enlarged; when it loses power, the blood accumulates in the lung, and to overcome this pulmonary resistance the right ventricle becomes hypertrophied. There is no strain on the left ventricle, and hence that cham- ber is not enlarged. Sequence.—Tricuspid regurgitation. Dilatation of the right ventricle prevents perfect closure of the tricuspid orifice, and relative insufficiency results. Mitral Insufficiency, or Mitral Regurgitation. Definition—Imperfect closure of the mitral orifice from rupture or inflammatory contraction of the mitral segments ; or from dilatation or weakening of the left ventricle, preventing perfect coaptation of normal valves. Physical Signs. Inspection. — Apex-beat forcible, and noted downward and to the left. The praecordia may bulge. Palpation confirms inspection. Percussion.—Increased area of dulness to the right and left. Auscultation.—A systolic murmur, with maximum inten- sity at the apex, and transmitted to the left axilla and to the angle of the scapula. Pulse.—During period of compensation normal, but very irregular when the heart weakens. 138 diseases of the circulatory system. Compensation.—The* left auricle enlarges from the extra amount of blood that it receives; when it weakens, the lungs become congested and right ventricular hypertrophy follows. The left ventricle also becomes hypertrophied from its effort to move the large quantity of blood which it receives from the distended auricle during each diastole. Sequence.-—Tricuspid regurgitation. Weakening and dila- tation of the right ventricle prevent perfect closure of the tri- cuspid orifice. Tricuspid Stenosis, or Tricuspid Obstruction. This lesion is comparatively rare. It gives rise to enlarge- ment of the heart and a presystolic murmur, which is heard most distinctly at the xiphoid cartilage. Tricuspid Insufficiency, or Tricuspid Regurgitation. Definition.—Imperfect closure of the tricuspid orifice from inflammatory shortening of the valves; or, more com- monly, from dilatation of the right ventricle secondary to mitral disease or to chronic lung disease. Physical Signs.—Enlargement of the heart; a systolic murmur, heard most distinctly just above the xiphoid cartilage, and associated with pulsation of the jugular vein, and in bad cases, with pulsation of the liver. Pulmonary Stenosis, or Pulmonary Obstruction. This very rare lesion is alvyays congenital, and may be sus- pected when a systolic murmur is heard most distinctly at the left second intercostal space, and is not transmitted into the vessels of the neck. Pulmonary Insufficiency, or Pulmonary Regurgitation. This is very rare, and is always congenital. It produces a diastolic murmur, which is heard most distinctly in the left second intercostal space. CHRONIC VALVULAR AFFECTIONS. 139 Period of Lost Compensation.—Lost compensation usually results from: (1) Increasing damage to the valves ; (2) senility, leading to arterial and cardiac degeneration; (3) some inter- current disease, throwing additional strain on the heart; and (4) undue physical exertion. During this period subjective symptoms appear. When the. heart weakens, no matter what the original valvular lesion was, it becomes unable to fill the arteries, and the blood is dammed back in the lungs, and venous congestion of the organs follows. Symptoms. — Pulmonary congestion produces dyspnoea, asthma, haemoptysis, and often chronic bronchial catarrh with cough and expectoration. Hepatic, stomachic, and intestinal congestion produce dys- pepsia. Renal congestion produces scanty albuminous urine, and later nephritis. General venous congestion produces cyanosis, and dropsy which begius in the feet and mounts upwards. Cerebral anaemia or congestion produces headache, vertigo, and syncopal attacks. In aortic disease, especially aortic stenosis, cerebral symp- toms are often marked. In mitral disease, pulmonary symp- toms are usually marked. Prognosis of Chronic Valvular Affections.—The extent of damage can never be accurately determined by the quality or intensity of the murmur. All things being equal, the following is probably the order of gravity in the various valvular lesions: (1) Tricuspid re- gurgitation, (2) aortic regurgitation (often ending in sudden death), (3) aortic stenosis, (4) mitral stenosis, and (5) mitral re- gurgitation. The following are unfavorable conditions : Early life, ad- vanced years, great cardiac enlargement, irregular heart-action, liability to recurring attacks of rheumatism, bad hygienic surroundings, and symptoms of congestion of the lungs, kid- ney or digestive tract. In proportion to the absence of these conditions, the prog- nosis becomes favorable. In many cases life is not materially shortened. 140 DISEASES OF THE CIRCULATORY SYSTEM. Treatment.—When compensation is perfect, the treat- ment is purely hygienic. When there is sudden heart-failure in valvular disease, in- dicated by orthopnoea and cyanosis, rest should be absolute, hot applications should be applied to the praecordia, and diffu- sible stimulants administered hypodermically : spirits of am- monia (20-30 minims), whiskey (30-60 minims), sulphate of strychnia (gr. ^, repeated once or twice), and especially nitro-glycerine (1-2 drops of one per cent, alcoholic solution) may be so employed; the last, in addition to being a highly diffusible stimulant, has the power of dilating the peripheral bloodvessels. Venesection (10-20 ounces) is of extreme value in these cases. When compensation is gradually lost, rest, a light, nutritious diet, and tinct. digitalis (10-20 drops three or four times daily) are the most important therapeutic measures. Tinct. strophan- tus sometimes succeeds when digitalis fails. Mild laxatives, such as massa hydrargyri (gr. 3-5), greatly influence the absorption of digitalis. When there is moderate dropsy the following pill is very efficient:— IJ. Mass. hydrargyri, Pulv. digitalis, Pulv. scillae, aa gr. xxiv.— At. Ft. in pil. No. xxiv. Sig.—One pill thrice daiiy. Strychnine is often a valuable adjunct to digitalis, especially when there are indications of fatty degeneration of the heart. When there is anaemia, iron is indicated, and it may be given with digitalis and strychnine, as in the following pill:— $. Strychnin, sulph., gr. j ; Pulv. digitalis, Ferri carb. sacchar., aa gr. xxx.—M. Ft. in pil. No. xxx. Sig.—One pill thrice daily. When there is much bronchitis and dyspnoea, digitalis with ammonia and senega is an efficient combination. (Barlow.) When dyspnoea is marked and the pulse is strong, nitro- glycerine (1-2 drops thrice daily, or gr. T^ thrice daily), if well borne, may be of much service. In extreme dropsy ACUTE ULCERATIVE ENDOCARDITIS. 141 free catharsis should be induced by compound jalap powder (gr. xx-xxx), or a concentrated solution of Epsom salts (Sss), and diuresis established by the infusion of digitalis (f,? ss-f.?j, thrice daily). In persistent anasarca, aspiration of serous sacs and puncture of the legs may be required. When there is excessive hypertrophy, indicated by praecor- dial distress and a full, regular pulse, without dropsy, aconite in small doses will prove efficient. ACUTE ULCERATIVE ENDOCARDITIS. (Malignant Endocarditis.) Definition.—A rapidly-destructive form of endocarditis, characterized by necrosis or ulceration of the valves aud the deposition of colonies of micrococci. Etiology.—It may begin as a primary disease, or be engrafted on a simple endocarditis. It may result in the de- bilitated from overwork or exposure ; it sometimes complicates the puerperium ; it generally follows septicaemia or one of the specific fevers—such as pneumonia, erysipelas, and scarlet fever. Pathology.—The valves are the seat of ulcers, deep ab- scesses, and soft, yellowish vegetations, which have undergone partial necrosis. Microscopic examination reveals myriads of micrococci. Symptoms. 1. General.—High and irregular fever, re- peated chills, profuse sweats, great prostration, often delirium and stupor, hurried breathing, rapid irregular pulse, brown fissured tongue. Jaundice and diarrhoea are frequently present. 2. Cardiac Symptoms.—Praecordial pain, palpitation, and often a blowing murmur at one or more of the valves. Mur- murs may be absent. 3. Embolic Symptoms.—Peripheral emboli yield a petechial * rash ; renal embolism may yield bloody urine; splenic em- bolism may yield a painful spleen ; cerebral embolism may yield paralysis. Diagnosis.—Is often difficult. Meningitis.—Cardiac symptoms, high fever, profuse sweats, and chills will usually separate it from meningitis. 142 DISEASES OF THE CIRCULATORY SYSTEM. Typhoid Fever.—Abrupt onset, cardiac symptoms, embolic symptoms, sweats, chills, and the absence of an abdominal rose-colored rash will separate it from typhoid fever. Malarial Fever.—In endocarditis the plasmodium malarioz is not found in the blood. Prognosis.—Almost invariably fatal. Duration is from a few days to several weeks. Treatment.—Ice-bags to the heart. Light nutritious diet. Stimulants. ACUTE MYOCARDITIS. Definition.—Acute inflammation of the heart muscle. Etiology.—It is almost always secondary to endocarditis or to pericarditis. As a primary affection of the heart, it may be due to rheumatism, or to one of the infectious fevers. Pathology.—The muscle substance is pale, flabby, and friable. Microscopic examination reveals fatty degeneration of the muscle fibres and an infiltration of the connective tis- sue with leucocytes. Symptoms.—The symptoms are often masked by the pri- mary disease. Dyspnoea, praecordial pain and distress, a weak, very rapid, small, and irregular pulse, a feeble impulse, and weak sounds suggest the condition. Treatment.—Absolute rest, and the use of cardiac stimu- lants, like strychnia, caffeine, digitalis, and alcohol. FIBROID HEART. (Myo-degeneration of the Heart, Chronic Myocarditis, Indurated Degeneration.) Etiology.—This condition is dependent upon atheroma or sclerosis of the coronary arteries. The indirect causes are rheumatism, gout, syphilis, alcoholism, endocarditis and peri- carditis. Pathology.—The heart is usually hypertrophied or dilated, and is the seat of grayish-white patches, which repre- sent overgrown connective tissue. The papillary muscles, HYPERTROPHY OF THE HEART. 143 columnae carneae, and the wall of the left ventricle near the apex are the parts most frequently affected. Arterial sclerosis causes necrosis, and this in turn is followed by a proliferation of the connective tissue. The fibroid areas sometimes yield to the endocardial pres- sure and cause aneurism of the heart. Symptoms.—It manifests the same symptoms as fatty de- generation, viz: dyspnoea, cough, weak and irregular pulse, palpitation, anginoid pains, dropsy, etc. Treatment.—Same as in fatty heart. HYPERTROPHY OF THE HEART. Definition.—Enlargement of the heart due to an over- growth of its muscle. Etiology.—It always results from increased work, and this may be due to : (1) Too much blood to be moved from the heart, as in the regurgitant valvular lesions. (2) Obstruc- tion to the outflow of blood at the valves, as in the stenoses; or in the pulmonary or the systemic circulation, as in emphysema and Bright's disease. (3) Resistance to ventricular contrac- tion by pericardial adhesions. (4) Undue physical exertion long continued. (5) Disturbed innervation from drugs, such as tobacco; or from disease, as exophthalmic goitre. Varieties.—(1) Simple hypertrophy. Thickened muscle and cavities of normal size. (2) Eccentric hypertrophy (hyper- trophy with dilatation). Thickened muscle and cavities di- lated. (3) Concentric hypertrophy. Thickened muscle and cavities diminished in size. Always congenital. Pathology.—The average weight of the normal heart is eight or nine ounces; in hypertrophy it may weigh two or three times as much. One or both chambers may be enlarged ; the left is the one most commonly affected. The muscle is firm and of a deep red color. Histologically the muscle-ele- ments are increased in size and number. Symptoms.—Unless the hypertrophy is more than compen- satory no symptoms result. Extreme hypertrophy is indicated by praecordial distress, palpitation, a strong pulse, and some- times by the phenomena of cerebral hyperemia, viz : flushed 144 diseases of the CIRCULATORY SYSTEM. face, ringing in the ears, flashes of light, headache, and dis- turbed sleep. Physical Signs. Inspection.—Praecordial bulging. For- cible impulse. The apex-beat is displaced downward and to the left. Palpation.—A heaving impulse. Percussion.—Increased area of cardiac dulness. Auscultation.—Sounds are dull and loud. Sequels.—Apoplexy, fatty degeneration of the heart and subsequent dilatation, valvular disease, and arterial degeneration. Diagnosis.—Hypertrophy and dilatation. These two con- ditions are commonly associated, but the preponderance of di- latation will be indicated by a feeble fluttering impulse, weak sounds, a weak, irregular, or intermittent pulse, and by symp- toms of heart-failure, such as dyspnoea, dropsy, etc. Treatment.—When the hypertrophy is excessive, recom- mend graduated exercise and a light diet, and employ such seda- tives as tincture of aconite (gtt. j-ij thrice daily) or tincture of veratrum viride (gtt. j-ij). The bromides are often valuable adjuncts. DILATATION OF THE HEART. Definition.—Enlargement of the heart due to stretching of its walls. Varieties.—(1) Dilatation with thickening of the walls (eccentric hypertrophy), and (2) Dilatation with thinning of the walls. Etiology.—Dilatation results from excessive endocardial pressure, as in sudden extreme exertion and in valvular disease, and (2) Impaired nutrition of the cardiac muscle, as in low fevers, valvular disease, and atheroma of the coronary arteries. Pathology.—One or both chambers may be dilated; the right is the one most commonly affected. The condition is usu- ally associated with hypertrophy and fatty degeneration. The muscle may be normal in appearance, but very frequently it is pale and soft. Symptoms.—So long as the associated hypertrophy keeps pace with the dilatation, no symptoms result; but when dila- tation preponderates, the following symptoms of venous FATTY DEGENERATION OF THE HEART. 145 stasis appear : dyspnoea, cough, dyspepsia, scanty urine, dropsy, and a feeble, irregular pulse. Disturbed innervation often causes praecordial distress and palpitation. Physical Signs.—Apex-beat is diffuse and weak ; it may be visible and yet not palpable (Walshe). When the right heart is involved an impulse is noted below the xiphoid carti- lage. Palpation.—A diffuse, feeble, and fluttering impulse. Percussion.—The area of dulness is increased, especially laterally. Auscultation.—The sounds are weak and sharp. The first sound loses its muscular element and resembles the second. Co-existing valvular lesions induce murmurs. Diagnosis.—Pericardial effusion. In this condition a fric- tion-sound is frequently present; the outline of dulness is py- riform with the base below, and is not nearly so broad as in dilatation; and the sounds are distant and muffled; and the apex-beat is displaced upwards. Treatment.—Rest. Light and nutritious diet. Improve the general condition by careful hygienic regulations, and the use of such tonics as iron, quinine, arsenic, and the like. Car- diac tonics, as digitalis, caffeine, strophanthus, and strychnia, are indicated. In sudden dilatation, use diffusible stimulants, as brandy, ammonia, strychnia, hypodermically. FATTY DEGENERATION OF THE HEART. Definition.—The term fatty heart is applied to (1) fatty infiltration, in which an abnormal amount of fat is deposited in and upon the heart; and (2) to fatty degeneration, in which the cardiac muscle has been metamorphosed into fat. Fatty Infiltration. Etiology.—It is a part of general obesity, and hence re- sults from an hereditary tendency, a rich diet, and sedentary habits. 10 146 diseases of the circulatory system. Pathology.—The heart may be completely imbedded in fat, the grooves along the larger bloodvessels being favorite seats of deposit. Fat is also found between the muscle fibres, although the latter may be perfectly normal. Symptoms.—Shortness of breath increased by exertion, a weak but regular pulse, praecordial distress, a tendency to pul- monary congestion, with a resulting obstinate bronchitis, and sluggish digestion. Prognosis.—Favorable. Treatment.—A regulated diet, in which the use of fats, starches, and sugars is restricted. Graduated exercise. The Turkish bath under supervision. Heart tonics, like digitalis and strychnia, are sometimes indicated. Fatty Degeneration of the Heart. Etiology.—(1) It follows hypertrophy in valvular disease. (2) It is frequently due to atheroma of the coronary artery. (3) It is a common result of malnutrition from old age, wast- ing disease, or anaemia. (4) It is associated with parenchyma- tous degeneration in the infectious fevers. (5) It results from mineral poisoning, as by arsenic, antimony, phosphorus. Pathology.—The muscle is pale, soft, and flabby, and feels greasy to the hand. Microscopic examination reveals a deposition of granular fat in the muscle-fibres. Symptoms.—When the condition is marked, it is charac- terized by all the symptoms of heart-failure, namely, dys- pnoea, asthma, cough, a weak, irregular pulse, which may be quite rapid or unusually slow, poor digestion, weak heart- sounds, a feeble apex-beat, dropsy, attacks of syncope, and, near the end, Cheyne-Stokes breathing. Disturbed innervation often causes palpitation, praecordial distress, and attacks of angina pectoris. There may be associated evidences of atheroma, namely, rigid arteries, and in the cornea, a fatty arcus senilis. Prognosis.—Unfavorable. Death may occur suddenly on slight exertion. Treatment.—Rest of mind and body. A carefully-regu- lated diet, which should be light but nutritious. Iron, angina pectoris. 147 quinine, and arsenic are sometimes indicated. In this condi- tion strychnia (gr. g^-go thrice daily) is often of great value. Nitro-glycerine (gr. Tfo or one minim of the one per cent. thrice daily) may relieve the distressing symptoms. Restless- ness, praecordial distress, and insomnia will call for morphia. In angina, hot applications should be applied to the praecor- dia, and nitrite of amyl administered by inhalation. ANGLNA PECTORIS. (Neuralgia of the Heart, Stenocardia.) Definition. — A paroxysmal affection characterized by severe pain radiating from the heart to the shoulder, thence down the arm ; by great anxiety, and fixation of the body, and apparently dependent upon some lesion of the cardiac arteries, walls, or valves. Etiology.—Male sex and middle life are generally predis- • posing factors. Syphilis, rheumatism, gout, alcoholism, and Bright's disease may lead to it by inducing atheroma of the coronary arteries. The attacks may come on without provocation, but eating and excitement, emotional or physical, usually induce them. In some instances the pain appears during sleep. Pathology.—Atheroma of the coronary artery, fatty de- generation of the heart, and valvular lesions are the conditions usually found after death. Their relation to angina is still a matter of conjecture. In rare instances, the condition is probably a pure neurosis, for no lesions are found. Symptoms.—Severe pain radiating from the praecordia to the left shoulder and thence down the arm. A sensation of tingling often accompanies the pain. There is great anxiety, a fear of approaching death, and fixation of the body. The face is pale or livid, and the brow bathed in sweat. Dyspnoea is often noted, and the pulse is variable, being usually tense and rapid. The duration of the attack is from a few seconds to several minutes. Diagnosis. Gastralgia.—The pain does not radiate to the shoulder and thence down the arm ; there is no fear of 148 diseases of the circulatory system. approaching death, and no fixation of the body ; the attack usually appears when the stomach is empty; there is no evi- dence of organic heart disease. Pseudo-angina, or Hysterical Angina.—This affection occurs chiefly in women of a neurotic temperament; is unassociated with organic heart disease; usually occurs at night; rarely induces fixation of the body; is of longer duration than true angina; and is associated with emotional excitement. Prognosis.—Grave. Sudden death is to be expected. The duration is often long, and in some instances recovery follows. The prognosis is more favorable when the paroxysms are mild, infrequent, unassociated with organic lesions, and brought on by exertion. Treatment. The Attack.—Inhalation of nitrite of amyl (a few drops on a handkerchief) and hot applications to the praecordia. If prompt relief does not follow, give sulphate of morphia (gr. I) with sulphate of atropine (gr. T^¥) hypoder- mically. The Interval.—Rest of body and mind. A carefully-regu- lated diet, which should be light but nutritious. Iodide of potassium (gr. x thrice daily) over a long course has been highly recommended. Nitroglycerine (gr. T\^ to -fa) when well borne is some- times extremely useful in warding off the attacks. Patients may be provided with glass capsules of nitrite of amyl. General tonics, like strychnia, iron, and arsenic, are often indi- cated. ANEURISM OF THE AORTA. Definition.—A circumscribed dilatation of the aorta. Etiology.—The male sex, middle life, and laborious work are general predisposing factors. The conditions which lead to arterial degeneration, like syphilis, rheumatism, gout, and alcoholism, are potent predisposing causes. Sudden exertion is commonly the exciting cause. Pathology.—Aneurisms are divided according to shape into the fusiform, saccular, and cylindrical forms. When all the arterial tunics have yielded, the dilatation is termed a true ANEURISM of the aorta. 149 aneurism ; when the internal tunic alone has ruptured, and blood has escaped between the layers, it is termed a false or dissecting aneurism. A true aneurism is composed (1) of an external or adven- titious sac which results from inflammation and condensation of the surrounding connective tissue; (2) of one or more of the degenerated coats of the vessel; and (3) of a clot, which is often firm and laminated. The arch of the aorta is the most common seat. About ten per cent, of aortic aneurisms are abdominal. Thoracic Aneurism. Physical Signs. Inspection.—This often detects an abnor- mal prominence and pulsation in the upper sternal region. Dilatation of the superficial veins may also be noted, and in advanced cases the skin over the prominence may be red and glossy. Palpation.—This often detects an expansile pulsation and a systolic thrill. If the cricoid cartilage is grasped between the fingers and thumb, and drawn upwards, a pulsation or tug may be trans- mitted to the trachea. Percussion.—This occasionally reveals circumscribed dul- ness and increased resistance. Auscidtation.—If the clot is not too large, the ear may detect a systolic bruit or murmur. Accentuation of the heart- sounds is often noted. Pulse.—The pulse in one radial may be delayed, and dimin- ished in volume from the diffusion or spending of the current within the sac, or from the partial occlusion of the arterial orifice. Symptoms. — Dyspnoea results from pressure upon the trachea, bronchi, or recurrent laryngeal nerve, the last causing spasm or paralysis of the vocal cords. Cough is rarely absent, and when due to spasm of the vocal cords it is of a metallic, barking character. Pain frequently results from pressure on the bones—ver- tebrae and sternum, or from irritation of neighboring nerves. 150 DISEASES OF THE CIRCULATORY SYSTEM. Dilatation or contraction of one pupil may result from pres- sure on the cervical sympathetic, and unilateral sweating of the face is sometimes induced by the same cause. Difficult swallowing (dysphagia) results from pressure on the oesophagus; and dilatation of the superficial veins, cyano- sis, and local oedema may result from pressure upon the deep- seated veins. Diagnosis.—A solid tumor may yield a transmitted pulsa- tion and simulate aneurism, but in the former the pulsation is up and down, not expansile, the impact is less pronounced, the bruit is usually absent, the heart-sounds are not accentu- ated, there is no tracheal tug, and the health is generally more impaired. Pulsating Empyema.—A left-sided purulent effusion may transmit a cardiac pulsation, but the latter is not expansile, the duluess is diffuse, the bruit is absent, and the history will suggest pleurisy. An expansile aorta may simulate aneurism. This condi- tion usually occurs in women of a neurotic temperament, and lacks the bruit and pressure-symptoms. Prognosis.—Always grave. The average duration is from one to two years. Death may result (1) from rupture exter- nally, or internally into the pericardium, heart, pleural sac, bronchi, lung, or oesophagus; (2) from exhaustion; (3) from heart-failure, for sometimes the aneurism dilates the aortic ori- fice and thereby causes aortic insufficiency. Treatment.—Mechanical treatment by ligation of distal arteries, acupuncture, and electrolysis, has not only been un- satisfactory, but has often shortened life. The treatment commonly employed is a modification of Tufnell's method, and consists in absolute rest in bed for from eight to twelve weeks, with a dry diet, and the administration of iodide of potassium, which is used empirically in doses of ten to twenty grains, thrice daily. When the pulse is very strong, heart sedatives like aconite and veratrum viride may be administered, or venesection cautiously practised. Pain is often temporarily relieved by the iodide, but when it is severe an ice-bag may be applied locally and morphia given hypoder- mically. arterio-sclerosis. 151 Aneurism of the Abdominal Aorta. Seat.—It is most frequently located near the coeliac axis. Symptoms.—It may be recognized by sharp pain in the back, radiating along the spinal nerves, and increased by eat- ing and drinking, by a delay in the femoral pulse, by gastro- intestinal symptoms, and by physical signs similar to those of thoracic aneurism. Diagnosis.—An abdominal cancer may receive a pulsation from the aorta, and simulate aneurism, but in the former, pul- sation is not expansile, and is frequently lost when the patient is placed in the knee-breast posture; and there is greater cachexia, and gastro-intestinal disturbance. The pulsating aorta of nervous women may simulate aneu- rism, but there are no pressure-symptoms, or distinct tumor, and it is in the sex in which abdominal aneurisms are very un- common. Prognosis.—Very grave. Death usually results from rupture. Treatment.—Same as in thoracic aneurism. Compression of the aorta, the patient having been anaesthetized, has given good results. ARTERIO-SCLEROSIS. (Atheroma, Gull and Sutton's Disease.) Definition.—A thickening of the arteries due to an over- growth of connective tissue, associated with more or less fatty degeneration and calcification. Etiology.—Old age, gout, rheumatism, alcoholism, syph- ilis, lead-poisoning, nephritis, and laborious work are predis- posing causes. Pathology.—The arteries are thickened, tortuous, and rigid. The intima reveals roughened and opaque areas, which are often the seat of calcareous deposits. In extreme cases there may be spots of necrotic softening in the subendothelial tissue, forming "atheromatous abscesses." Microscopic ex- amination shows more or less fatty degeneration of the different coats, and an overgrowth of connective tissue in the intima. 152 DISEASES OF THE CIRCULATORY SYSTEM. Symptoms. Circulatory Phenomena.—Rigidity of the pe- ripheral vessels, a sluggish, high-tension pulse, accentuation of the second aortic sound, palpitation, dyspnoea, anginoid pains, and hypertrophy of the left ventricle. Renal Phenomena.—The urine is increased in quantity, is pale in color, and of low specific gravity. It may contain a trace of albumin and a few hyaline casts. Cerebral Phenomena.—Headache, vertigo, disturbed sleep, failure of memory, and tinnitus aurium. Sequelae.—Cerebral congestion, apoplexy, angina pectoris, aneurism, interstitial nephritis, gangrene of the extremities. Treatment.—A careful regulation of the habits, clothing, and diet. Stimulants must be avoided. Iodide of potassium (gr. v thrice daily) has been recommended for its absorbent effect. Nitroglycerine is sometimes valuable in overcoming the high arterial tension. DISEASES OF THE RESPIRATORY SYSTEM. THE NOSE. The Red Nose.—A nose which is permanently and uni- formly red generally indicates alcoholism or acne rosacea. A nose which is permanently red and swollen at the extremities, and has a broadened bridge, indicates chronic hypertrophic rhinitis. Flattening of the Bridge.—This may result from trauma- tism or tertiary syphilis. Movement of the Alae Nasi during Respiration.—Playing of the alae is occasionally noted in health, but it is generally an indication of some obstruction to the entrance of air. It is frequently observed in spasmodic croup, true croup, laryngeal oedema, capillary bronchitis, and pneumonia. Nasal Discharge.—Temporary "running from the nose" is a symptom of acute coryza, measles, hay-fever, diphtheria, and influenza. An offensive discharge should suggest nasal diphtheria, or the impaction of a foreign body. Chronic discharge occurs in chronic rhinitis. In infants, chronic nasal discharge with mouth-breathing (" snuffles") is very suggestive of hereditary syphilis. The Sense Of Smell.—This is tested by holding odoriferous substances before one nostril at a time while the other is closed. Pungent vapors should be avoided, as the irritation which they excite, and not their odor, may lead to their recognition. J ' (153) 154 DISEASES of the respiratory system. The sense of smell is impaired or lost (anosmia) from :— 1. Rhinitis or morbid growths. 2. Affections of the anterior part of the brain, involving the olfactory nerves or bulbs—as injury, tumor, meningitis. 3. Lesions of the olfactory centres. "4. Paralysis of the trigeminal nerve (by inducing dryness of the mucous membrane). 5. Old age. An increase (hyperosmia) or a perversion (parosmia) of the sense of smell may occur in hysteria, insanity, and as an aura of epilepsy. Epistaxis.—Hemorrhage from the nose occurs under the following conditions: (1) Traumatism. (2) Inflammation. (3) Obstructed circulation—as in chronic heart, lung, and liver disease. (4) Blood-dyscrasia—as in scurvy, infectious fevers, haemophilia, and purpura. (5) Onset of fevers, especially typhoid. (6) Vicarious menstruation. (7) In rarefied atmo- sphere, as in mountain-climbing. (8) Often without obvious cause. THE LARYNX. Spasm of the laryngeal adductors is characterized by intense dyspnoea and occurs in spasmodic croup; in true croup; in ulceration of the larynx ; in laryngismus stridulus ; in whoop- ing-cough ; in tetany ; in hysteria ; in hydrophobia ; in the laryngeal crisis of locomotor ataxia; when foreign bodies have lodged in the larynx; and when aneurisms or mediastinal tumors press on the recurrent laryngeal nerve and irritate it. Aphonia or loss of voice may occur:— 1. In severe inflammation of the larynx. 2. From hysteria. 3. In centric paralysis of the recurrent laryngeal nerves, as in bulbar palsy and in tumors of the medulla. 4. In peripheral paralysis of the recurrent laryngeal nerve caused by the pressure of an aneurism, mediastinal tumor, or pericardial effusion. 5. From prolonged use of the voice. 6. From the lodgment of foreign bodies. 7. From cicatricial stenosis of the larynx. RESPIRATION. 155 Paralysis of the Laryngeal Muscles. Paralysis of all of the muscles. Complete uni- lateral paraly- Complete par- alysis of the abductors. Unilateral par- alysis of the abductors. Complete par- alysis of the adductors. Causes. Hysteria ; bulbar pal- sy ; pressure upon both vagi or spinal accessories. Pressure upon one re- current laryngeal by an aneurism or tu- mor. Catarrhal laryngitis; bulbar palsy; pres- sure on both vagi or recurrents; hysteria. Pressure on one recur- rent by an aneurism or mediastinal tumor. Hysteria; laryngitis; prolonged use of the voice. Symptoms. Aphonia, but no cough or dyspnoea. Voice weak and rough; no cough or dyspnoea. Voice quite natural; inspiratory stridor and dyspnoea; no cough. Hoarseness; fatigue after moderate use of the voice; slight dys- pnoea. Aphonia, but no cough or dyspnoea. Laryngoscopic Appearance. The cords are midway between adduction and abduction, and are motionless (" cad- averic position"). One cord is moder- ately abducted and motionless; the other is drawn beyond the median line in pho- nation. The cords are near to- gether, and brought still closer by inspi- ration. One cord is near the median line, and is motionless on inspi- ration. Cords are open and move naturally on respiration, but are motionless during at- tempted phonation. RESPIRATION. Dyspnoea.—JDyspnoea implies- difficult breathing with or without an increase in the number of respirations. Dyspnoea which is so severe as to necessitate a sitting posture is termed orthopnoea. Dyspnoea may occur on inspiration, expiration, or both. Dyspnoea on expiration is chiefly noted in pulmonary emphy- sema and asthma. Dyspnoea on inspiration, or on both inspiration or expira- tion. In this form the base of the chest is retracted during the violent inspiratory efforts. Its chief causes are: (1) Obstruction in the larynx from spasm, paralysis, false membrane, oedema, or a foreign body. (2) Pressure of an aneurism, tumor, or large glands upon the trachea, bronchi, or recurrent laryngeal nerve. (3) Asthma. (4) Diseases of the lungs, as pneumonia, emphysema, oedema, phthisis, abscess, and gangrene. (5) Pleural effusions. (6) Cardiac disease. (7) Paralysis of the muscles of respira- tion. (8) Abdominal distention. (9) Anaemia. 156 DISEASES OF THE RESPIRATORY SYSTEM. The number of respirations per minute. In the healthy male adult the number of respirations is about 18 to 20 per minute. In women and children, breathing is somewhat more rapid. The ratio between respirations and pulse-beats is 1 to 4 or 4.5. Rapid, respirations are noted in excitement; in pyrexia; in inflammatory diseases of the lungs ; in anaemia ; in certain affec- tions involving the base of the brain; in poisoning from certain drugs which affect the respiratory centre; in hysteria; in painful affections of the respiratory muscles, as pleurodynia, pleurisy. Infrequent respirations are observed in certain diseases of the brain, as meningitis, tumor, apoplexy; in advanced fatty degeneration of the heart; in certain forms of coma, particularly uraemic and diabetic; in poisoning with certain drugs, espe- cially opium; in obstruction to the air-passages, as in asthma and in laryngeal spasm. Cheyne-Stokes, or tidal-wave breathing. In this type the respirations gradually increase in rapidity and volume until they reach a climax, then gradually subside and finally cease entirely for from five to fifty seconds, when they begin again. It depends on some disturbance of the respiratory centre the exact nature of which is still undetermined. It is usually a forerunner of death, but cases have been reported in which it has lasted several months. Its chief causes are: (1) Certain cerebral diseases, as apo- plexy, meningitis, and. tumor. (2) Advanced cardiac disease, especially fatty degeneration. (3) Certain forms of coma, espe- cially that produced by uraemia, opium-poisoning, and sun- stroke. COUGH. Cough results from: (1) All diseases of the lungs and bronchi. (2) Many diseases of the larynx. (3) Foreign bodies in the air-passages. (4) Certain* infectious diseases, most of which, however, are associated with catarrh, as whoop- ing-cough, measles, influenza. (5) Inhalation of irritating vapors or gases. (6) Reflex causes, such as pressure on the recurrent laryngeal nerve by an aneurism, and uterine and gastro-intestinal affections. (7) Hysteria. EXPECTORATION. 157 Laryngeal Cough.—This cough has a hard, metallic, ringing intonation, and has been termed "croupy". It is observed in laryngitis; in whooping-cough ; in tuberculosis and syphilis of the larynx ; when a foreign body has lodged in the larynx; when au aneurism or mediastinal tumor presses on the recur- rent laryngeal nerve, and irritates it; and in hysteria. Dry Cough.—Cough without expectoration is especially ob- served in the beginning of inflammatory diseases of the bronchi and lungs; in pleurisy ; in most chest diseases of early child- hood ; and in the reflex variety Moist, or loose COUgh occurs in bronchitis, bronchiectasis, convalescent pneumonia, and phthisis. EXPECTORATION. Mucoid sputum is noted especially in the beginning of acute bronchitis ; in asthma ; in the early stage of pneumonia ; and in pulmonary oedema. In the last it is very frothy and watery. Muco-purulent Sputum.—This is observed in subacute and chronic catarrhal affections of the lungs and bronchi, espe- cially in chronic bronchitis, convalescent pneumonia, and phthisis. Purulent Sputum.—Sputum is rarely composed of pure pus. Expectoration almost entirely purulent is observed in bron- chiectasis, in phthisis with cavities, in abscess of the lung, and when an empyema ruptures into the lung. Prune-juice Sputum.—Expectoration tinged with altered blood so as to resemble prune-juice. It results from reten- tion of the blood in the lung, and is observed in advanced croupous pneumonia, especially low forms, in gangrene of the lung, and in cancer in the lung. Rusty Sputum.—A rusty and tenacious sputum is strongly indicative of croupous pneumonia. Sputum containing fibrous shreds is observed in membra- nous croup, in diphtheria, and in fibrinous bronchitis. Currant-jelly sputum is indicative of cancer in the lungs. Fetid sputum usually results from bronchiectasis, advanced phthisis with cavities, gangrene of the lung, and abscess of the lung. 158 DISEASES OF THE RESPIRATORY SYSTEM. Such sputum when allowed to stand in a conical glass set- tles in three layers: an upper layer of dirty froth, a middle layer of turbid mucus in which are suspended purulent strings, and a bottom layer of decomposed pus. Nummular Sputum.—Sputum found in round, flat, coin- shaped masses, which are heavy and sink in water. This sputum is observed in advanced phthisis, in chronic bron- chitis, and in bronchiectasis. THE MICROSCOPY OF SPUTUM. Elastic fibres are found in the sputum in phthisis, abscess, gangrene of the lungs, and in some cases of bronchiectasis. Fig. 10. Elastic Fibres. The Detection of Elastic Fibres.—Place the sputum which has collected during the night in a glass beaker, and add to it an equal volume of a solution of caustic soda (20 grains to the ounce), and boil over a spirit-lamp, stirring it occasionally with a glass rod. As soon as it boils pour into a conical glass, and add four or five times the amount of cold distilled water. Allow the mixture to stand for two to three hours, and exam- ine the sediment as for tube-casts. (Fenwick.) Spirals of Mucin.—Tightly-coiled spirals of mucin, which probably represent moulds of the fine bronchioles, were first pointed out by Curschmann in the sputum of asthma. They have also been observed in the sputum of croupous pneumonia. THE MICROSCOPY OF SPUTUM. 159 Charcot-Leyden's Crystals.—These are small transparent octahedral crystals, similar to those found in the blood of leu- caemia. They are observed especially in the sputum of asthma. They have also been noted in phthisis, in fibrinous bron- chitis, and in acute bronchitis. Fig. 11. Charcot-Leyden's Asthma Crystals. (After Riegel.) Crystals Of Fatty Acids.—These occur as fine needles, singly or in bundles, and are often sharply curved near their extremities. They are observed in the sputum of chronic bronchitis, of abscess, and of gangrene of the lungs. Crystals Of H»matoidin.—These occur as small yellow needles, rhombic plates or tufts, and are found in sputa which contain altered blood. They may be observed in abscess, gangrene, and cancer of the lungs. Tubercle Bacilli.—The presence of tubercle bacilli in the sputum is an absolute proof of tuberculosis, but a failure to detect them after one or two examinations is no proof against 160 DISEASES OF THE RESPIRATORY SYSTEM. phthisis. The bacillus is a fine rod, in length about half the diameter of a red-blood corpuscle, and often slightly bent and beaded. Its detection depends on its power, when stained, of resisting the bleaching effect of acids. To view it successfully, a ^L- oil immersion lens is required. Fig. 12. Needles of Fatty Acids. (After Striimpell.) Its Detection.—The Weigert-Ehrlich method: Select with a clean needle a minute portion from the thick part of the spu- tum, spread it out in a very thin film on a cover-glass, and dry by holding it several inches above the flame of a spirit-lamp. When cool place it in the staining fluid, which is prepared as follows: Mix 5 c. c. of aniline oil with 100 c. c. of distilled water, and filter, and then add 11 c. c. of a saturated alcoholic solution of fuchsine. The cover-glass should remain in this staining fluid about half an hour (in doubtful cases, twenty- four hours); when stained, rinse in distilled water, and then decolorize by placing the specimen for a few seconds in a thirty per cent, aqueous solution of nitric acid. Wash off the acid with distilled water, and again stain by immersing the cover-glass for about a minute in an aqueous solution of methy- lene-blue, or in a one or two per cent, aqueous solution of Bis- marck-brown ; now rinse, dry, and mount in Canada balsam. PHYSICAL EXAMINATION OF RESPIRATORY ORGANS. 161 PHYSICAL EXAMINATION OE THE RESPIRATORY ORGANS. Inspection. Inspection determines the shape of the chest, any unnatural prominence or depression, the amount of expansion, and any inequality of expansion. Fig. 13. An Outline of the Normal Chest. Phthisinoid Chest.—The antero-posterior diameter is short; the thorax is long and flat; the ribs are oblique ; the scapulae are prominent; the spaces above and below the clavicles are depressed ; and the angle formed by the divergence of the cos- tal margins from the sternum is very acute. Rachitic Chest.—This may resemble the former, but usually the sides are considerably flattened, and the sternum promi- nent, so that the term pigeon-breast has been applied to this particular form. The sternal ends of the ribs are enlarged or " beaded," and this characteristic has given rise to the term " rachitic rosary." There is often a circular constriction of the thorax at the level of the xiphoid cartilage. Emphysematous Chest. — In advanced emphysema the thorax is short and round; the antero-posterior diameter is often as long as the transverse diameter ; the ribs are horizon- tal ; the angle formed by the divergence of the costal margin 11 162 DISEASES OF THE RESPIRATORY SYSTEM. Fig. 14. Rachitic Chest. from the sternum is very obtuse or quite obliterated. The term " barrel-shaped chest" is applied to this configuration. Fig. 15. Emphysematous Chest. Local Prominences and Depressions.—An unnatural promi- nence or depression is often observed over the lower part of the sternum, and is generally congenital. The term funnel- breast or shoemaker's-breast (because it may result from the pressure of tools) has been applied to the sternal depression. A Unilateral or Local Depression may be due to: (1) Phthisical consolidation. (2) Cavity. (3) Pleurisy with fibrous adhesions. A Unilateral or Local Prominence may be due to: (1) Pleurisy with effusion. (2) Pneumothorax, hydrothorax, PHYSICAL EXAMINATION OF RESPIRATORY ORGANS. 163 haemothorax. (3) An aneurism or tumor. (4) Compensatory emphysema, resulting from impairment of the opposite lung. (5) Cardiac enlargements (left side). (6) Enlargements of the abdominal organs, especially the liver and spleen. Expansion.—In women and in children, breathing is largely thoracic, or costal; in men and in the old of both sexes, it is largely abdominal, or diaphragmatic. Restricted abdominal breathing is observed in pregnancy, in abdominal tumors and effusions ; in peritonitis ; in diaphrag- matic pleurisy ; in paralysis of the phrenic nerve from pressure or from bulbar disease; and occasionally in the " hysterical abdomen." Palpation. Palpation serves to detect any thoracic tenderness, oedema, friction-fremitus, or rales, and to determine the vocal fremitus and amount of expansion. Thoracic tenderness is observed in pleurisy ; in phthisis, and pneumonia from being associated with pleurisy ; in pleuro- dynia ; in intercostal neuralgia (confined to certain spots); and in surgical affections, like caries and fracture of the ribs; and in contusion and inflammation of the parietes. (Edema Of the Chest walls is recognized by " pitting" when pressure is made wTith the finger. It may be observed in em- pyema ; in deep-seated abscesses of the parietes; after the application of a blister; and in general dropsy. Friction-fremitus and Rales.—The friction-sound of pleu- risy aud harsh sonorous rales can sometimes be detected by palpation. Vocal, or Tactile Fremitus.—The transmission of the vibra- tions of the voice to the hand. In determining the vocal fremitus observe the following pre- cautions : Palpate symmetrical parts of the chest; make firm pressure; when comparing use the same pressure on the two sides; apply the hands as nearly parallel to the ribs as possible ; and remember that the fremitus is normally in- creased over the right apex. 164 DISEASES OF THE RESPIRATORY SYSTEM. Vocal fremitus is increased in : (1) Phthisical consolidation. (2) Pneumonic consolidation. Vocal fremitus is decreased in: (1) Pleural effusions—air, pus, serum, lymph, or blood. (2) Emphysema. (3) Pulmo- nary collapse from an obstructed bronchus. (4) Pulmonary oedema. (5) Morbid growths of the lung. Percussion. Percussion determines resonance, pitch, and resistance. Immediate percussion is performed by striking the chest di- rectly with the fingers. It is not often employed, except over the clavicles, where the bones themselves act as pleximeters. Mediate percussion is performed by using the fingers of one hand as a plessor, and those of the opposite hand as a plexi- meter ; or by using a piece of ivory, glass, or hard rubber as a pleximeter, and a small hammer as a plessor. The use of the fingers alone is preferable, for only in this way can resistance be determined. In percussion the following precautions should be observed : Place the finger which is being used as a pleximeter firmly against the chest, and preferably parallel to the ribs; make the finger which is used as plessor strike the one on the chest perpendicularly ; fix the forearm, and use no more force than can be obtained from a gentle swing of the wrist. When pos- sible, percuss all parts of the chest anteriorly and posteriorly ; percuss both in inspiration and in expiration. In comparing the two sides, be sure to percuss symmetrical parts. Normal Resonance.—On the right side, pulmonary resonance extends from a half inch to an inch above the clavicle, down- ward to the upper border of the sixth rib in front, and to a line drawn through the tenth spinous process posteriorly. On the left side, pulmonary resonance extends from a half inch to an inch above the clavicle, downward, within the mam- mary line to the third rib, outside of the mammary line to the tenth rib, and posteriorly to a line drawn through the tenth spinous process. Hyper-resonance is observed in the following conditions: (1) Pneumothorax. (2) Cavities—tuberculous or bronchiec- tatic. (3) Emphysema. (4) Lowered pulmonary tension in AUSCULTATION. 165 the initial stage of pneumonia and above a pleural effusion (Skoda's resonance). (5) Flatulent distention of the stomach or colon (frequently observed over the left base). .1 tympanitic note is a hollow, drum-like sound like that which is normally obtained by percussing the larynx or empty stomach. The above conditions are also capable of producing tympany. The cracked-pot sound, or bruit de pot fele, is a modified tympany, and can be simulated by percussing over the cheek when the mouth is partially open. It may be normally heard over the chest of a crying infant (Walshe). In the adult it usually indicates a cavity which has a free communication with a bronchus. It is best detected by keeping the ear near the open mouth of the patient while percussing. DulneSS or flatness is recognized in the following condi- tions : (1) Phthisical consolidation. (2) Pneumonic consoli- dation. (3) Pleural effusions of all kinds, except air. (4) Col- lapse of the lung. (5) Congestion and oedema of the lung. (6) Enlargement of the liver or spleen (at the bases). (7) Morbid growths in the lung. # Pitch___Pitch depends largely upon the volume of air, upon the tension of the walls of the cavity, and upon the size of the opening which communicates with the cavity. The less the air, the greater the tension, and the smaller the opening, the higher will be the pitch of the note. It is obvious, therefore, that conditions which are associated with hyper-resonance may yield either a high-or a low-pitched note. In beginning phthisical consolidation, the note over the affected apex is higher pitched; but it must be borne in mind that normally the note over the right apex is higher pitched than that over Resistance.—The greater the dulness the greater will be the resistance ; hence there is always more resistance oyer a large pleural effusion than over a pneumonic or phthisical con- solidation. Auscultation. Auscultation determines the character of the breathing and of the vocal resonance, and detects adventitious sounds, like rales. 166 DISEASES OF THE RESPIRATORY SYSTEM. In immediate auscultation the ear is placed directly over the chest, a soft towel only intervening. In mediate auscultation the sounds are transmitted through a stethoscope, which should be applied to the bare chest. In auscultation observe the following precautions : Do not exert much pressure with the stethoscope; when the chest is covered with hair moisten the latter, otherwise it will produce friction-sounds resembling rales. When possible, auscult all over the chest, anteriorly and posteriorly; auscult on quiet breathing, on full inspiration, on full expiration, and after coughing. In comparing the two sides auscult symmetrical parts. Normal Respiration.—Vesicular breathing is heard over the body of the lungs, and is characterized by a soft, breezy inspi- ration and a short, low-pitched expiration. Normally, expi- ration is not more than one-third as long as inspiration. Aus- cultation over the trachea, or over the main bronchi in the interscapular space, yields bronchial breathing, i. e., harsh breathing with prolonged high-pitched expiration. Modifications of the respiratory murmur. Puerile Breath- ing.—This type is heard normally over the lungs of children ; it is loud, and expiration is higher pitched than in vesicular breathing, and almost as long as inspiration. Exaggerated Breathing.—This type has almost the same peculiarities as puerile breathing, and is heard over a lung that is doing extra work necessitated by some impairment of its fellow. Bronchial or Tubular Breathing.—Harsh breathing, with a prolonged high-pitched expiration, which has sometimes a tubular quality. Bronchial breathing is heard over: (1) Phthisical consolidation. (2) Pneumonic consolidation. (3) Lung which is compressed. (4) Lung which is infiltrated with a morbid growth. Amphoric and Cavernous Breathing.—These two are almost identical; the sounds are loud, and expiration is prolonged and hollow. The pitch of amphoric breathing is a little higher than that of cavernous. Amphoric breathing may be imitated by blowing over the mouth of an empty jar. Amphoric or cavernous breathing may be heard in the fol- AUSCULTATION. 167 lowing conditions: (1) Phthisical or bronchiectatic cavities. (2) Pneumothorax, when the opening in the lung is patulous. (3) Areas of consolidation near a large bronchus. (4) Some- times over lung compressed by a moderate effusion. Asthmatic Breathing.—Harsh breathing with a prolonged wheezing expiration. It may resemble bronchial breathing, but, unlike the latter, it is heard all over the chest. The Breathing of Emphysema.—Weak breathing, with pro- longed low-pitched or inaudible expiration. Cogged-wheel, or Jerky Breathing.—The respiratory murmur is not continuous, but is broken into waves. It is not indicative of any special disease, but it is frequently observed in bron- chitis and in incipient phthisis. Weak or Shalloiv Breathing.—This is noted : (1) When the chest-walls are thick. (2) In the old and feeble. (3) In emphysema. (4) In pleural effusion. (5) In incipient phthisis. (6) In painful affections of the chest, like pleuro- dynia and beginning pleurisy. (7) In pulmonary oedema. Vocal Resonance.—The vibrations of the voice transmitted to the ear. Vocal resonance is normally more marked over the right apex. It is abnormally increased in: (1) Pneumonic consoli- dation. (2) Phthisical consolidation. (3) Cavities which freely communicate with a bronchus. Vocal resonance is diminished or absent in: (1) Pleural effusions—air, pus, serum, lymph, or blood. (2) Emphysema. (3) Pulmonary collapse. (4) Pulmonary oedema. Bronchophony.—Extreme exaggeration of the vocal resonance; the sounds, but not the words, are transmitted. It is especially noted over marked consolidations and over certain cavities. Pectoriloquy.—The distinct transmission of articulate speech to the ear; the words appear to emanate from the spot which is ausculted. Pectoriloquy is heard over: (1) Cavities which communicate with a bronchus. (2) Areas of consolidation in the neighbor- hood of a large bronchus. (3) Pneumothorax, when the open- ing in the lung is patulous. (4) Some pleural effusions. yEgophony.—A modified bronchophony, characterized by a trembling, bleating sound. It is usually heard over slight 168 DISEASES OF THE RESPIRATORY SYSTEM. pleural effusions near the upper border of dulness, especially near the inferior angle of the scapula. It is occasionally heard in beginning pneumonia. Adventitious Sounds. Rales, or Rhonchi.—These are abnor- mal sounds which replace or accompany the respiratory murmur. f Vesicular = Crepitant. Pulmonary rales ■{ /Sonorous. _ ,. ,\my {Sibilant. L Bronchial J (Subcrepitant. v Moist < Bubbling. (Gurgling. Extra-pulmonary rales = Pleuritic friction-sounds. Crepitant Rales.—These are very fine rales, and are heard at the end of inspiration. They may be simulated by rubbing a lock of hair between the fingers. They have been especially associated with the first stage of croupous pneumonia, and it has been supposed that they were due to the forcible separation of adherent vesicular walls. Rales very similar to, if not iden- tical with these, are heard in capillary bronchitis and in pul- monary oedema. Dry rales are probably produced by the presence of viscid secretion in the tubes; they have a more or less whistling, musical, or squeaking intonation. They are heard particularly in bronchitis and asthma. Sibilant rales are whistling and high pitched ; sonorous rales have a humming quality and are lower pitched. Dry mles may be heard on inspiration, expi- ration, or both. Moist rales result from the presence of liquid in the tubes ; the thinner the liquid and the larger the tube, the coarser will be the rales. They may be heard on inspiration, expiration, or both. Subcrepitant, or crackling rales are fine moist rales, and heard in all conditions which are associated with liquid in the smaller tubes, as bronchitis, capillary bronchitis, pulmonary oedema, and beginning phthisis. Bubbling rales are coarser than subcrepitant; and are heard in bronchitis, in resolving croupous pneumonia, over phthisical deposits which are softening, and over small cavities. AUSCULTATION. 169 Gurgling rales are very coarse and resemble the bursting of large bubbles. They are heard over large cavities which con- tain fluid, and in the trachea in the so-called " death-rattle." Friction-sounds are produced by the rubbing together of roughened pleural surfaces. They may be heard both in in- spiration and expiration, and often resemble subcrepitant rales, but they are more superficial and localized than the latter, and are not modified by cough or deep inspiration. A roughened pleura in the neighborhood of the heart may produce a friction-sound of cardiac rhythm, and one which will still continue when the breath is held; under other condi- tions pleural friction-sounds cease when respiration is sus- pended. Other Adventitious Sounds. Metallic Tinkling.—This name is applied to silvery or bell-like sounds which are heard at in- tervals over a pneumo-hydrothorax or large cavity. Speaking, coughing, and deep breathing usually induce them. Care must be taken not to confound them with similar sounds pro- duced by the presence of liquid in a distended stomach. Succussion-splash, or Hippocratic Succussion.—This is a splashing sound produced by the presence of air and liquid in the chest. It may be elicited by gently shaking the patient while auscultating. It nearly always indicates either a hydro- or a pyo-pneumothorax, although it has been detected over very large cavities. Air and liquid in the stomach produce a similar sound. Mensuration. In measuring the sides of the chest observe the following precaution : Measure from the middle of the sternum to the spinous processes; measure both sides after inspiration and after expiration ; apply the tape with equal firmness to the two sides. In comparing, measure corresponding levels, and re- member that the right side is from half an inch to an inch greater in circumference than the left. The conditions which render one side more prominent than the other have already been considered. 170 DISEASES OF THE RESPIRATORY SYSTEM. COKYZA. (Acute Rhinitis, Cold in the Head.) Definition.—An acute inflammation of the nasal cavities. Etiology.—Exposure to cold drafts and to wet, especially when the body is overheated, is a common cause. It may be excited by the inhalation of irritating vapors or dust. It is an expression of iodism. It is a symptom of certain infectious diseases—especially syphilis, measles, and influenza. Pathology.—The mucous membrane is red and swollen. In the first stage there is no secretion, but later irritating, watery mucus flows from the nose and excoriates the lip; this in time is followed by a copious muco-purulent discharge. Symptoms. — The disease is ushered in with chilliness, malaise, fulness in the head, and sneezing. The nasal cham- bers are obstructed, so that the patient is obliged to breathe through his mouth. At first there is no secretion, but in twenty-four or forty-eight hours a watery discharge is estab- lished, which later becomes muco-purulent. Slight fever and its associated symptoms are commonly present. The duration is from a few days to two weeks. Complications.—The disease is often accompanied with conjunctivitis, pharyngitis, laryngitis, and catarrh of the Eustachian tube and middle ear which results in temporary deafness. Prognosis.—Favorable. Treatment.—In the early stage a cold in the head can frequently be aborted by the use of hot drinks, a laxative, moderate doses of quinine, and the application of menthol to the nasal chambers. Some crystals of menthol may be placed in a wide-mouth bottle, and their vapor inhaled for from ten to twenty minutes several times during the day. A spray of menthol may be employed :— fy Menthol, 3j ; 01. amygd. dulcis, vel benzoiual, f^iij.—M. Sig.—Spray into the nose several times daily. chronic nasal catarrh. 171 Cocaine is often efficient in allaying the fulness and distress; a four per cent, solution may be applied to the nose on a pledget of cotton or by means of a camel's-hair brush. When the symptoms are severe Dover's powder (gr. v) may be given in combination with quinine (gr. v) thrice daily. CHRONIC NASAL CATARRH. (Chronic Rhinitis.) Definition.—A chronic inflammation of the nasal mucous membrane, characterized by increased secretion and impair- ment of the sense of smell. Etiology.—Repeated attacks of acute coryza, impure air, the continual inhalation of irritating dusts or vapors, lowered vitality, and congenital or acquired obstruction of the nasal chambers are causal factors. It is also au expression of syphilis. Varieties.—Two varieties have been recognized : Chronic hypertrophic rhinitis and chronic atrophic rhinitis. Hypertrophic Rhinitis. Symptoms.—A thick mucous dis- charge from the nose; great liability to attacks of acute coryza ; obstruction of one or both nasal cavities, causing mouth-breathing; a nasal intonation of the voice; frontal headache ; and impairment of the sense of smell. Symptoms of catarrh of the neighboring organs are fre- quently present. The most common of these are : dryness of the throat and hawking from pharyngitis; deafness from catarrh of the middle ear; and watering of the eyes from catar- rhal occlusion of the lachrymal canal. Inspection.—The bridge of the nose is frequently flattened, and the alae are thickened and red; the mucous membrane is red and the cavities are more or less occluded from hyper- trophy of the cavernous tissue covering the turbinated bones. In advanced cases exostoses from the bony framework are sometimes noted. Prognosis.—Under judicious and persistent treatment the affection is curable. Treatment.—The naso-pharynx must be kept clean by 172 DISEASES OF THE RESPIRATORY SYSTEM. means of antiseptic douches or sprays; Dobell's solution (see page 31) or the following may be employed for this purpose:— R Sodii boratis, Sodii bicarbonatis, aa 3ss ; Sodii benzoatis, Sodii salicylatis, aa gr. ij ; Sodii chloridi, gr. vij ; Eucalyptol, thymol, aa gr. j ; Menthol, gr. ss; Olei gaultherise, gtt. j ; Glycerini, f^ss; Alcoholis, f3j; Aqus, q.s. ad Oj.—M. Mild astringent sprays are often useful, and sulphate of zinc or sulphate of copper (five to ten grains to the ounce) may be employed for this purpose. Tonics like cod-liver oil, hypophosphites, iron, arsenic, and strychnia are often indicated. To effect a cure the naso-pharynx must be unobstructed; hypertrophies and exostoses must be removed and deviations of the septum corrected by surgical means. Atrophic Rhinitis. (Ozcena.) Symptoms.—A sense of dry- ness in the nose and throat; a thick purulent discharge, or the expulsion of discolored crusts ; an offensive, putrid odor, which has given rise to the term Ozseua; impairment of the sense of smell. The general health is always poor; such patients are usually thin and anaemic. Inspection.—The chambers are large ; the mucous membrane is pale, dry, and glazed ; adherent scabs are generally present. In advanced cases, ulceration and necrosis are observed. Prognosis.—Perfect cure is rarely obtainable; but treat- ment may effect great improvement. Treatment.—Crusts must be removed and the nasal chambers kept clean with antiseptic sprays or douches. Stim- ulating applications are useful, and solutions of nitrate of silver, sulphate of iron, or sulphate of zinc may be employed. A 30 per cent, solution of lactic acid is also recommended. Ebstein uses tampons soaked in balsam of Peru. When there is much purulent discharge a 20 per cent, mixture of ichthyol in cosnioline is very efficient. (Jeneral tonics like cod-liver oil, hypophosphites, iron, arsenic, etc. are indicated. ACUTE CATARRHAL LARYNGITIS. 173 ACUTE CATARRHAL LARYNGITIS. Definition.—An acute catarrhal inflammation of the larynx, characterized by hoarseness, hard cough, and painful deglutition. Etiology.—Improper use of the voice ; exposure to cold and wet; the inhalation of irritating dusts or vapors; the im- paction of foreign bodies are its common causes. It is also an associated condition in certain infectious diseases, like whoop- ing-cough, measles, diphtheria, and influenza. Pathology.—The mucous membrane is red, swollen, and injected. In grave cases the tissues may be markedly oedematous. Symptoms.—Hoarseness of the voice or aphonia ; hard, ringing cough; pain in the throat increased by speaking, coughing, and swallowing ; expectoration, which is first scanty and later muco-purulent; fever and its associated symptoms. In sensitive people, and especially in children, paroxysms of croupy cough and dyspnoea (false croup) may result from spasm of the vocal cords ; and when there is much oedema, dyspnoea or asphyxia will be a prominent feature. Inspection.—The mucous membrane of the laryngeal walls and vocal cords is red and swollen. In grave cases the tissues are highly oedematous. Prognosis.—In simple laryngitis without oedema the prog- nosis is altogether favorable. The attack usually lasts from a week to ten davs. When there is oedema of the larynx, indicated by dyspnoea or asphyxia, the prognosis is grave. Treatment.—The patient should be confined to his room and preferably to bed. The temperature of the room should be 70° or 75°, and the atmosphere should be moistened by the generation of steam. Iodine or in severe cases an ice-bladder, should be applied to the throat. The inhalation of medicated vapors is decidedly useful, and one of the following may be employed ^Lime- water Dobell's solution, wine of ipecac (diluted with two volumes of water), or the menthol mixture mentioned in the treatment of acute coryza. 174 diseases of the respiratory system. Internal Treatment.—A saline laxative may be administered at the beginning, and followed by one of the following seda- tive mixtures: Dover's powder (gr. v) with quinine (gr. v) thrice daily, or:— fy Potassii citratis, Potassii bromid., aa ^ij ; Apomorph. hydrochlor., gr. £ ; Aqua? et syr. sarsaparillae comp., aa fgiss—M. Sig.—A teaspoonful every two hours to a child of five years. Or—One of the following tablets devised by Dr. Seiler :— I£ Potass, chlor., Potass, bromid., Pulv. ext. glycyrrhizse, aa 3J ; Tinct. ferri chlor., f^ss ; Sacchar., etc., q. s.—M. Ft. in trochisci No xx. Sig.—One every three or four hours. CEdema of the larynx, indicated by extreme dyspnoea, will require scarification of the mucous membrane or tracheotomy. CHRONIC LARYNGITIS. Simple Chronic Catarrhal Laryngitis. Symptoms.—Tick- ling in the throat, huskiness of the voice, fatigue and pain after moderate use of the voice, and the expectoration of viscid mucus are the usual symptoms. Laryngoscopic examination reveals redness of the mucous membrane and sometimes slight ulcerations. Treatment.—The patient must learn to use the voice properly ; sounds must be expelled by the abdominal muscles and diaphragm, and not by the muscles of the throat. Flan- nel protectors should be avoided, and the application of cool water to the neck, night and morning, instituted in their stead. Tonics are generally indicated. Expectorants which are elim- inated by the respiratory mucous membrane are useful; and one of the following may be employed : Terebene (gtt. v on sugar), oleoresin of cubebs (gtt. x-xx on sugar), oil of euca- lyptus (gtt. v in capsule). CHRONIC LARYNGITIS. 175 Topical Treatment.—A faradic current to the neck is often beneficial; medicated solutions should be applied to the larynx by means of a brush or atomizer. The following are the remedies commonly employed : Nitrate of silver, chloride of ammonium, chlorate of potassium, sulphate of zinc, and tinc- ture of benzoin. Tuberculous Laryngitis—This is nearly always secondary to pulmonary tuberculosis, but it occasionally occurs as a pri- mary affection. Symptoms.—Hoarseness of the voice or aphonia; pain in the throat increased by coughing, speaking, or swallowing; and hacking cough are the usual symptoms. Laryngoscopy Examination.—The mucous membrane is pale aud thickened; the arytenoid cartilages are considerably swollen ; small, irregular, shallow ulcers with gray bases are frequently noted, particularly in the inter-arytenoid space. Treatment.—Remedies must be directed to the primary pulmonary disease. Local applications are required to relieve the pain. Powders of iodoform or morphia may be dusted on the ulcers, or a solution of nitrate of silver, of cocaine, or of menthol may be applied by means of a laryngeal brush. Syphilitic laryngitis may manifest itself in catarrhal in- flammation, or mucous patches, but the most common expres- sion is a gummatous infiltration, which breaks down, ulcerates the cartilages, and ultimately leads to cicatrization and de- formity. Symptoms.—Hoarseness of the voice, hacking cough, and some difficulty in deglutition. Subjective symptoms are often absent, though examination may reveal extensive lesions. Laryngoscopic Examination.—Deep ulcers with raised edges, often symmetrically arranged. Necrosis of the cartilages re- sults in advanced cases. Diagnosis.—The history, the presence of other syphilitic lesions, the deep symmetrical ulcers, the effect of treatment, and the absence of marked pain and of pulmonary lesions will serve to distinguish it from tuberculous laryngitis. Treatment.—The system should be rapidly brought under the influence of antisyphilitic remedies ; for this purpose mer- 176 DISEASES OF THE RESPIRATORY SYSTEM. curial inunctions may be employed, and iodides and mercurials given internally :— r£ Hydrarg. chlor. corros., gr. j ; Potass, iodidi, 3ii-3iv ; Syr. sarsaparilte comp., f^jss ; Aquse, q. s. ad f|iij.—M. Sig.—A teaspoonful twice daily after meals. Local applications, carefully applied by the aid of the laryn- goscopy mirror, are also required. Iodoform, or acid nitrate of mercury (1 to 5 of water), may be selected for this purpose. When the laryngeal movements interfere with healing, tracheotomy should be performed. The same operation or mechanical dilatation is sometimes required for the resulting cicatricial stenosis. SPASMODIC CROUP. (False Croup.) Definition.—Spasm of the vocal cords, excited by catarrh of the larynx. Etiology.—The attacks usually occur in young children, and are induced by the causes of catarrhal laryngitis. Symptoms.—Generally there has been a little hoarseness and cough during the day, and at night the child is awakened from sleep by a severe paroxysm of suffocative cough. The latter has a peculiar, hard, metallic quality, and is associated with the evidences of dyspnoea, namely : Anxious face, dilating nostrils, prominent sterno-cleido-mastoids, and retraction of the base of the chest with each inspiratory effort. During the paroxysm the skin is hot and the pulse is tense and rapid. In from a few moments to an hour the cough ceases, free perspi- ration follows, and the child falls to sleep. Two or three similar attacks may occur in the same night, but on the following day the child appears quite well. A recurrence of the seizures for several successive nights is not infrequent. Diagnosis. Laryngismus Stridulus.—This is a pure neu- rosis, and is often associated with the rachitic diathesis. The paroxysms resemble those of false croup, but are associated MEMBRANOUS CROUP. 177 with a peculiar crowing inspiration, and lack catarrhal symp- toms, such as hoarseness and cough. Prognosis.—Always favorable. Treatment.—A sponge moistened with hot water may be applied to the throat, or the child may be placed in a hot bath. If these simple measures fail, an emetic will almost invariably bring relief. Wine of ipecac (3j) or turpeth mineral (gr. iij-v) may be selected. Subsequent treatment should be directed to the laryngeal catarrh. MEMBRANOUS CROUP. (Croupous Laryngitis, True Croup, Pseudo-membranous Laryngitis.) Definition.—A non-infectious inflammatory disease of the larynx, characterized anatomically by the formation of false membrane, and clinically by hoarseness, barking cough, and dyspnoea of gradual development. Etiology.—The formation of false membrane in the larynx usually results from diphtheria; but a membranous inflamma- tion, non-infectious, is sometimes observed. Early childhood (between two and five years) and exposure to cold and wet are the predisposing causes. A membranous laryngitis may also result from the direct action of strong acids or alkalies, scalding water, or steam. Pathology.—The larynx is lined with a gravish-white pseudo-membrane which is more or less adherent The fauces are rarely involved, but the membrane occasionally extends to the trachea. The escape of the fauces is a point of difference between membranous croup and diphtheria, for in the latter the fauces are usually primarily involved. The membrane is quite superficial, and rarely involves the submucous tissue. Under the microscope a fibrillar network is found, in the meshes of which are leucocytes and epithelial cells. Symptoms.—The disease usually begins with the symptoms of catarrhal laryngitis, namely, hoarseness, barking cough, and slight fever. Soon paroxysms of spasmodic croup appear, and in the intervals dyspnoea gradually develops. The respira- tions are rapid and noisy, and are often associated with a 12 178 DISEASES of the respiratory system. whistling, stridulous inspiration. There is moderate fever. With the increasing dyspnoea, the child grows extremely rest- less ; the head is forcibly extended; the alae of the nose play; the sterno-cleido-mastoids stand out prominently; and the base of the chest retracts with each violent inspiratory effort. In the paroxysms of coughing, a piece of false membrane may be detached and expectorated. Hoarseness soon gives place to aphonia; and the cough, at first harsh, gradually becomes in- audible. Finally, the lips become blue; the pulse weakens; the temperature falls; and the respirations become inaudible. Death is often preceded by stupor and convulsions. Diagnosis. Spasmodic Croup.—The dyspnoea is parox- ysmal ; the attacks usually appear at night, and often in the midst of apparent health; and no false membrane is expecto- rated. In true croup the dyspnoea develops gradually and becomes extreme, and false membrane may be expectorated. Laryngeal Diphtheria.—The detection of false membrane in the fauces, a history of contagion, grave systemic symptoms, albuminuria, and such complications as paralysis, endocarditis, and nephritis would indicate diphtheria. Laryngismus Stridulus.—This is a nervous affection, charac- terized by paroxysms of dyspnoea accompanied by a peculiar crowing inspiration. The attacks occur periodically in the midst of apparent health, and lack fever and catarrhal symp- toms. Prognosis.—Unfavorable; from sixty to eighty per cent. perish within a week or ten days. The more local the dis- ease, the older the patient, and the more vigorous he is, the better the prognosis. A return of voice and audible breath- ing, a loose cough, and purulent expectoration are favorable indications; but increasing rapidity and weakness of the pulse, cyanosis, and debility indicated fatal issue. Treatment.—The temperature of the room should be kept at 70°, and the atmosphere should be moistened by the gene- ration of steam. A steam atomizer may be employed, or lime may be slacked in the room. Medicated sprays are sometimes recommended; some turpentine or oil of eucalyptus may be added to the water in the receiver of the atomizer, or may be placed on the surface of water which is kept boiling over a laryngismus stridulus. 179 stove or spirit-lamp. Hot fomentations or an ice-bladder may be applied to the neck. The best internal solvent at our command is mercury. A fiftieth of a grain of the bichloride may be given, well diluted, every hour or two to a child a year old, or a quarter of a grain of calomel may be given every hour to a child of the same age, and if it excites diarrhoea, a little paregoric may be administered with each dose. ty. Hydrarg". chlor. corros., gr. £ ; Ammon. chlor., gr. xij ; Aquse, f^iij.—M. Sig.—A teaspoonful diluted with a dessertspoonful of water every hour to a child a year old. Quinine (gr. iij in suppository) may be employed three or four times daily. Stimulants are frequently indicated. An emetic may assist in the expulsion of loose membrane. Turpeth mineral (gr. iij-v), alum, or ipecac may be selected. Topical Medication.—In the very young it may be impos- sible to bring medicated sprays in contact with the affected parts, but when it is feasible much benefit accrues from this method of treatment. Among the solutions recommended may be mentioned, lime-water, Dobell's solution, lactic acid (1 to 10 or 20), and peroxide of hydrogen ; a fifty per cent. solution of the last is often very efficient. When these remedies fail, and the dyspnoea and cyanosis in- crease, and the pulse grows rapid and irregular, intubation or tracheotomy must be performed. The results of intubation are somewhat more encouraging than those of tracheotomy. Between thirty and forty per cent, recover after these opera- tions. LARYNGISMUS STRIDULUS. (Spasm of the Glottis, "Child-crowing.") Definition. — A paroxysmal neurosis, characterized by spasm of the adductors of the larynx, and not excited by any local inflammation. 180 DISEASES OF THE RESPIRATORY SYSTEM. Etiology.—Early life (within the first two years), male sex, and the rachitic diathesis are the predisposing causes. The discharge of motor force apparently arises in the medulla (bulbar epilepsy), and may be excited by reflex irritation, as in teething and gastro-intestinal disorders. Symptoms.—The attacks often occur on waking from sleep, and are characterized by a sudden arrest of breathing and tonic muscular spasms. The face is pale, and later cyanosed; the eyes are rolled up; the body is arched; the thumbs are turned into the palms ; the legs are extended, and the soles turned inward. In a few seconds the spasm relaxes, and air is drawn through the glottis with a shrill, crowing sound. The seizures vary greatly in frequency; several may occur in a day, or they may be weeks apart. Diagnosis.—The intermittent character of the affection; the peculiar crowing inspiration ; the absence of fever, cough, and hoarseness will serve to distinguish laryngismus from croup. Prognosis.—Favorable. In the very young death may result from suffocation. Treatment. The Paroxysm.—Cold water may be dashed on the face and head, or a few drops of nitrite of amyl or chloroform may be placed on a handkerchief and held before the nose. The Interval. — Careful search should be made for some exciting cause; the gums may require lancing, or the gastro- intestinal tract may demand attention. The child should be placed under the best hygienic conditions. The food should be plain and nutritious; tonics, like cod-liver oil, malt, hypo- phosphites, and arsenic, are generally indicated. The bromide of potassium is an efficient antispasmodic, and may be advan- tageously combined with antipyrin :— $. Antipyrin, gr. xxiv-xlviij ; Potass, bromid., Siss-^ij ; Syr. aurant. cort., fgij; Aquse, q.s. ad fgiij.—M. Sig.—A teaspoonful thrice daily. CEDEMA OF THE LARYNX. 181 (EDEMA OF THE LARYNX. (CEdema of the Glottis.) Definition.—An infiltration of serous fluid into the sub- mucous tissue of the larynx. Etiology.—It occasionally results from severe attacks of catarrhal laryngitis. It may be induced by severe inflamma- tion of neighboring organs—as the tonsils, parotid glands, and pharynx. It may be a complication of some acute infec- tious disease—like diphtheria, scarlet fever, or facial erysipelas. It is sometimes associated with ulcerative affections of the larynx, like tuberculosis and syphilis. It may be excited by the irritation of burns, scalds, or caustics. It occasionally occurs abruptly in the course of Bright's disease. Pathology.—The connective tissue of the larynx is infil- trated with a serous or sero-purulent fluid. The mucous mem- brane is tense and changed in color. Symptoms.—Hoarseness of the voice, and later aphonia; extreme dyspnoea, at first on inspiration but later on expiration also; stridulous respiration; barking cough; and the evi- dences of dyspnoea, namely: Anxious face, protruding eyes, blue lips, prominent sterno-cleido-mastoids, and retraction of the base of the chest. When the epiglottis is involved the swelling can be detected by the finger on the throat. Laryngoscopy Examination. — The mucous membrane is swollen and of a red dish-purple color. The epiglottis may resemble a round translucent tumor. In infraglottic oedema the upper part of the larynx may appear normal, but swollen and oedematous membrane is seen projecting through the glottis. The vocal cords are rarely affected. Prognosis.—Extremely grave. Treatment.—When the symptoms are not urgent, leeches or blisters may be applied over the larynx, and astringent solu- tions (tannic acid or alum) sprayed on the oedematous tissues. When the symptoms persist, the parts should be scarified, and if this fails to relieve the dyspnoea, tracheotomy should be performed. 182 diseases of the respiratory system. BRONCHITIS. Definition.—An inflammation of the bronchial tubes, characterized by substernal soreness, cough, muco-purulent expectoration, and dry and moist rales. Varieties.—(1) Acute catarrhal bronchitis. (2) Chronic bronchitis. (3) Capillary bronchitis. (4) Fibrinous bron- chitis. Acute Catarrhal Bronchitis Etiology.—A cold, damp climate; changeable weather; occupations which necessitate confinement, or the inhalation of irritating dusts or vapors; debility ; the gouty diathesis; and chronic heart disease are general predisposing factors. Exposure to cold and wet, particularly when the body is overheated, or the inhalation of irritating gases or dusts is the usual exciting cause. Acute bronchitis is also an associated condition in certain infectious diseases, especially measles, whooping-cough, typhoid fever, and influenza. Pathology.—In most cases the trachea and large tubes only are affected. The mucous membrane is red, swollen, in- jected, and more or less covered with tenacious muco-pus. Microscopic examination reveals desquamation of epithe- lium and infiltration of the submucous tissues with leucocytes. Symptoms.—Chilliness; malaise; a sense of soreness and constriction behind the sternum, which is increased by cough- ing ; slight fever (100°-102°) with its associated symptoms ; cough at first dry and painful, but later accompanied by muco-purulent expectoration which becomes quite free as the inflammation subsides. Physical Signs.—Inspection, palpation, and percussion usually give negative results. Auscultation at first reveals sibilant and sonorous rales on both sides of the chest, and in the second stage, when secretion is established, moist rales. Diagnosis. Influenza—High fever, intense pain in the head, back, and limbs, and great prostration will serve to dis- tinguish influenza from bronchitis when the former is prevalent. bronchitis. 183 Catarrhal Pneumonia.—Moderately high and irregular fever, prostration, rapid breathing, dyspnoea, and physical signs indi- cating consolidation will serve in the recognition of pneumonia. Prognosis.— Favorable. In the old, young, and feeble there is danger of its leading to capillary bronchitis or catar- rhal pneumonia. Treatment.—The abortive treatment consists in the use of hot foot-baths, a mustard plaster to the chest, the internal administration of hot drinks, and a full dose of Dover's pow- der (gr. x) with which quinine may be advantageously com- bined. This method is only applicable in the initial stage, and to those patients who are willing to remain indoors for the fol- lowing twenty-four hours. The young, old, and enfeebled should be confined to bed. A turpentine stupe, mustard plaster, or iodine may be applied to the chest. In the early stage when there is substernal pain with little or no expectoration, sedative expectorants, like ipecac, the veg- etable salts of potassium, antimony, and apomorphia are indi- cated ; and it is well to combine with them an opiate to check the harassing cough. IJ. Potass, citrat., ^ss ; Apomorphinse hydrochlor., gr. j ; Syr. ipecac, f^ss; Succi limonis, f^ij ; Syr. simp., q. s. ad f^iv.—M. (Wood.) Sig.—A dessertspoonful, in water, every three hours. Or— IJ. Vini ipecacuanha?, f ^ij ; Liq. potass, citrat., fgiv ; Tinct. opii camph., Syr. acaciae, aa fgj.—M. (DaCosta.) Sig.—Tablespoonful thrice daily. In severe cases with dyspnoea, inhalations from a steam atomizer often give relief. Wine of ipecac (with twice its volume of water), tincture of lobelia, or tincture of conium may be employed for this purpose. In the later stages, when expectoration has been established, stimulating expectorants are indicated ; chloride of ammonium, squills, senega, terebene, tar, or eucalyptus may be selected :— 184 DISEASES OF THE RESPIRATORY SYSTEM. IJ Amnion, chlor., gr. xl; Syr. scillse, Tinct. opii camph., Ext. prun. virgin, fl., aa f^ss ; Syr. acacia? et aqua?, aa q. s. ad f^iv.—M. Sig.—A tablespoonful every three hours. Or— IJ. Tinct. opii camph., f31J ; Syr. prun. virgin., f^iss ; Syr. picis liquidse, q. s. ad f §iv.—M. Sig.—A tablespoonful thrice daily. Or— IJ Terebeni, f.^ss. Sig. —Five drops on sugar, gradually increased to ten thrice daily. Chronic Bronchitis. (Chronic Bronchial Catarrh, Winter Cough.) Etiology.—It may result from the continuation of an acute attack ; but it most commonly develops gradually from the causes which induce the acute disease, namely, a cold, damp climate, changeable weather, gouty diathesis, chronic nephritis, and heart disease. It is especially common in the old. It is an associated condition in emphysema, phthisis, chronic interstitial pneumonia, and in many cases of asthma. Pathology.—The mucous membrane of the bronchi is sometimes thickened and roughened from an overgrowth of the connective tissue; in other cases the mucosa is thin from atrophic changes. The surface is usually covered with muco- pus ; ulcers are occasionally noted. Long-standing bronchitis leads to dilatation of the tubes (Bronchiectasis) and to emphysema. Symptoms.—Persistent cough, and more or less muco-puru- lent expectoration ; a sense of soreness behind the sternum. Fever is usually absent, and unless the disease is very severe, the general health may be fairly well preserved. Dyspnoea on exertion is a troublesome symptom ; it however belongs more to the resulting emphysema than to the bronchitis. Physical Sions.—Unless emphysema has developed, in- spection, palpation, and percussion give negative results. BRONCHITIS. 185 Auscultation reveals rales, some of which are dry and wheezing, while others are moist and bubbling. Special Varieties.—(1) Rheumatic bronchitis. (2) Bron- chorrhoea. (3) Dry catarrh. Rheumatic Bronchitis.—This form occurs in those of a rheu- matic diathesis, and is characterized by severe paroxysmal cough, the expectoration of scanty tenacious mucus, and by aching pains in various parts of the chest. It is especially in- fluenced by atmospheric changes, and does not yield to the ordinary treatment of bronchitis. Bronchorrhoea.—This term is applied to cases of chronic bronchitis which are associated with a very copious expectora- tion. The sputum is generally muco-purulent, and sometimes very offensive (Fetid bronchitis). Dry Catarrh.—This form, described by Laennec as catarrhe sec, is characterized by severe spells of coughing which are accompanied by little or no expectoration. It is generally seen in the old in association with emphysema or asthma. Diagnosis. Phthisis.—The absence of fever, of hemorrhage, of bacilli in the sputa, and of signs indicating consolidation will serve to distinguish chronic bronchitis from phthisis. Bronchiectasis.—This often results from chronic bronchitis. Very profuse fetid sputa, expelled periodically in gushes, and perhaps physical signs of cavity over the main bronchi, poste- riorly, indicate bronchiectasis. Emphysema.—Much dyspnoea, distention of the chest, hyper- resonance on percussion, and a prolonged feeble expiration on auscultation indicate emphysema. Sequelae.—Emphysema, bronchiectasis, and dilatation of the right ventricle Prognosis.—Perfect recovery is rarely attainable, but the disease is not incompatible with long life. Treatment.—A careful regulation of the hygiene; this includes attention to diet, clothing, bathing, exercise, etc. Bronchitis dependent on heart or kidney disease will require remedies directed to those organs. The general vitality is frequently reduced, and tonics like cod-liver oil, hypophos- phites, iron, quinine, and strychnia are often valuable adjuncts to the special treatment. A change of climate often secures 186 DISEASES OF THE RESPIRATORY SYSTEM. permanent relief. In this country the extreme south-western territory, including New Mexico, Arizona, and Southern Cali- fornia, possesses many atmospheric advantages. Alteratives like iodide of potassium (gr. v-x thrice daily) are often serviceable in chronic bronchitis with little expectoration. Counter-irritants—blisters, tincture of iodine, or croton oil— prove useful. Stimulating expectorants—chloride of ammonium, terebene, tar, eucalyptus, oil of sandalwood, and copaiba—are generally indicated :— IJ Amnion, chlor., Ext. glycyrrhiza?, aa ^ij ; Syr. lactucar. et aqua?, aa q. s. ad fgvj.—M. Sig.—A tablespoonful thrice daily. Or— IJ Copaiba?, ^iij ; Acacia? et sacchar. alb., aa q. s. ; Spt. lavandula? comp., f^ss ; Aqua?, q.s. ad f^vj.—M. Sig.—A tablespoonful thrice daily. Or— IJ. Apomorphina? hydrochlor., gr. £ ; Syr. prun. virg., f|ij ; Syr. picis liquida?, fgiv.—M. (Murrell.) Sig.—A tablespoonful thrice daily. Or— IJ Terebeni, f^ss. Sig.—Five to ten drops on sugar thrice daily. The method of treating chronic bronchitis by inhalations, which has been so ably advocated by Dr. Murrell of London, is extremely useful, especially in patients with weak stomachs, in whom syrups should be avoided. Wine of ipecac (with twice its volume of water), terebene (with equal parts of benzoinol or liquid vaseline), creasote, or carbolic acid may be so employed. IJ Acid, carbol., gr. xxx ; Tinct. opii camph., f^iij.—M. (N. S. Davis.) Sig.—A fluid drachm with half a pint of'hot water in the inhaler, thrice daily. An inexpensive inhaling apparatus is made by Codman & Shurileff, of Boston. BRONCHITIS. 187 Capillary Bronchitis. (Suffocative Catarrh.) Definition. — An inflammation of the smaller bronchi, generally secondary to simple bronchitis. Etiology.—Simple bronchitis is apt to involve the capil- lary tubes in the young, old, and debilitated. It is often a coniplication of certain infectious fevers—like measles, whoop- ing-cough, diphtheria, and influenza. Pathology.—The mucous membrane of the finer tubes is red, swollen, and injected, and the tubes are filled with tena- cious mucus. In most cases more or less catarrhal pneumonia results from the extension of the inflammation into the air-vesicles. Areas of collapse from occlusion of the bronchi are often observed. Symptoms.—Severe spells of coughing, which in children are unaccompanied with expectoration ; rapid respirations (60 to 80 per minute) ; dyspnoea; high fever (104°-105°); and a weak, rapid pulse. Later the lips become blue, the extremities cold, and the mind dull, and death frequently results in a few days from exhaustion and asphyxia. Physical Signs.—Inspection reveals evidences of dyspnoea : Playing of the alae of the nose, blue lips, anxious face, promi- nent sterno-cleido-mastoids, and retraction of the base of the chest from obstruction to the entrance of air. Percussion.—The resonance may be normal, but large areas of collapse or pneumonic consolidation will yield dulness. Auscultation.—Weak breathing, and whistling sibilant rales or fine, crackling, moist rales. Diagnosis. Catarrhal Pneumonia.—This is a natural out- come of capillary bronchitis and usually complicates it. The detection of areas of consolidation in catarrhal pneumonia is the only diagnostic difference. (Edema of the Lungs.—The history of some chronic causal disease and the absence of fever will assist in the diagnosis of oedema. Prognosis.—In young children it is very grave. In older and more vigorous patients the prognosis is much more favorable. 188 DISEASES OF THE RESPIRATORY SYSTEM. Treatment.—Absolute rest. The temperature of the room should be kept uniformly at 70° or 75°. The atmosphere should be rendered moist by the generation of steam. A tur- pentine stupe may be applied to the chest, which should be protected by a cotton jacket. The diet ought to be liquid or semi-liquid and nutritious. Stimulants are frequently indi- cated. Quinine may be given in suppository as a support to the system. Carbonate of ammonium is an invaluable cardiac and respiratory stimulant in these cases :— IJ Amnion, carb., gr. xv ; Pulv. acacia? et sacchar., aa q. s. ; Spt. lavandula? comp., fgij ; Aqua?, q. s. ad f.^ij.—M. Sig.—A teaspoonful every two hours to a child of two or three years. When the dyspnoea is marked an emetic is useful in expel- ling mechanically mucus from the bronchi. Wfine of ipecac (3ss-3j for a child) may be selected. When the fever is high, it should be reduced by sponging with cool water, or by the cold bath. Fibrinous Bronchitis. (Croupous Bronchitis, Pseudo-membranous Bronchitis.) Definition.—A primary inflammatory disease of thebronchi associated with the formation of false membrane. Etiology.—The causes are unknown. Male sex, early manhood, and chronic pulmonary disease, like phthisis, emphy- sema, and pleurisy, appear to be predisposing factors. Pathology.—The disease is often limited to a certain num- ber of bronchi. Some of the affected tubes are found filled with a fibrinous exudate, while others are found empty and show a loss of epithelium. The casts are usually expelled in the form of whitish balls, and when unrolled in water present branching moulds of the divisions and subdivisions of the affected bronchi. On close examination they are found to be hollow and laminated. Under the microscope, a homogeneous or fibrillated membrane is observed, imbedded in which are DILATATION OF THE BRONCHIAL TUBES. 189 leucocytes, fat-drops, particles of pigment, epithelial cells, and occasionally Leyden's octahedral crystals. Symptoms.—Acute and chronic forms are recognized. The former is rare, and manifests the symptoms of a severe attack of acute bronchitis, but the sputa contain fibrinous casts, and there is marked dyspnoea. The chronic form is characterized by severe cough, parox- ysms of dyspnoea, and the expectoration of fibrinous plugs. The physical signs are those of chronic bronchitis. The disease often lasts a few weeks, and then disappears to return again at definite periods. Prognosis.—In the acute variety the prognosis must be guarded: death frequently results from suffocation. The chronic variety runs a very protracted course. Treatment.—In the acute disease, the atmosphere of the room should be kept moist and uniformly warm. Calomel (gr. I every two hours) may be administered as in other mem- branous inflammations, and may be followed by iodide of potassium. Inhalations of alkaline vapors (lime-water) exert a solvent effect. Counter-irritants should be applied to the chest. Emetics sometimes aid in the expulsion of casts. In the chronic form iodide of potassium may be given in conjunction with stimulating expectorants. DILATATION OF THE BRONCHIAL TUBES. (Bronchiectasis.) Definition.—A universal or circumscribed dilatation of the bronchi. Etiology.—Chronic inflammation of the tubes and the contraction of surrounding pulmonary tissue are the prime causes ; hence, it is generally secondary to chronic bronchitis, phthisis—particularly fibroid—chronic interstitial pneumonia, and chronic pleurisy with adhesions. Pathology.—The dilatation results from weakening and atony of the tubes, and from their subjection to strain in coughing, or to the traction of shrinking connective tissue, as in fibroid phthisis. Two forms are noted : (1) The cylindrical form, in which 190 DISEASES OF THE RESPIRATORY SYSTEM. the tubes, particularly those of medium size, are uniformly dilated in one or both lungs; and (2) the saccular form, in which the tubes swell out, here and there, into circumscribed dilatations which may reach several inches in diameter. This form is especially noted in fibroid phthisis. The walls of the bronchiectatic cavity are extremely atrophied, the surface is generally smooth and shining, but ulcerations are not un- common. Symptoms.—Cough, dyspnoea, and copious expectoration. The last is characteristic; it is apt to occur periodically in gushes; the material has a highly offensive odor, and when allowed to stand in a glass vessel separates into three layers : an upper layer of dirty brown froth, a middle layer of turbid mucus, and an under layer of decomposed pus. Microscopi- cally it contains pus corpuscles, fat crystals, crystals of haema- toidin, and numerous microorganisms, but no tubercle bacilli. Elastic fibres are rarely found. Physical Signs.—In the cylindrical variety the signs are those of chronic bronchitis. The saccular variety may present the signs of tuberculous cavities, localized tympany, cavernous breathing, gurgling rales, and pectoriloquy. Diagnosis. —The differentiation of bronchiectasis from phthisis is difficult and often impossible. The discovery of tubercle bacilli always indicates phthisis. Bronchiectatic cavi- ties are usually located in the lower lobes, and rarely in the apices. Prognosis.—This will depend on the primary disease; since the common causes are long-standing bronchitis and fibroid phthisis, there can be little hope of cure. Amelioration is all that can be expected. Treatment.—Tonics are often indicated. Stimulant and antiseptic expectorants like turpentine, terebene, eucalyptus, oil of sandalwood, and tar are sometimes useful. Inhalations of terebene, carbolic acid, or dilute peroxide of hydrogen lessen cough and destroy the fetid odor of the breath. Codein (gr. |) may be employed to allay cough. ASTHMA. 191 ASTHMA. Definition.—Paroxysmal dyspnoea due to spasm of the tubes or to swelling of their mucous membrane. Etiology.—Asthma is a symptom of several diseases, but a hypersensitive condition of the mucous membrane of the re- spiratory tract appears to be essential to its production. When this condition prevails, asthma may be induced (1) by the pul- monary congestion of cardiac disease (Cardiac asthma); (2) by the uraemic intoxication or transient pulmonary (edema of Bright's disease (Renal asthma); or (3) by some irritant from without, as the pollen of plants (Hay asthma). (4) Sometimes the paroxysms are excited by the most trivial causes, as an atmospheric change or a peculiar odor, and to this form many writers restrict the term asthma. This last will be discussed under the head of essential asthma. Essential Asthma. (Bronchial Asthma, Nervous Asthma, Spasmodic Asthma.) Etiology.—Nervous temperament, an hereditary tendency, early life, disease of the naso-pharynx, and the gouty diathesis, are predisposing factors. Barometric and thermometric changes; the inhalation of dust; the odor of certain plants, animals, or fruits; excite- ment ; reflex irritation, particularly a loaded stomach; a change of locality ; and bronchial catarrh, are exciting causes. Pathology.—The disease is a pure neurosis, and the par- oxysms probably result from a spasm of the smaller tubes, or turgescence of their mucous membrane. Symptoms.—The paroxysms often appear suddenly, but in some cases certain symptoms precede and give warning of the approaching attack ; among these are chilliness, flatulence, sneezing, and a copious discharge of pale urine. The patient is often seized at night. There is a sense of oppression and anxiety followed by dyspnoea so intense that he runs to the window for air, or sits upright with his arms in such a position that he can bring into play the auxiliary muscles of respiration. The face is pale, the lips blue, the eyes prominent and con- 192 DISEASES OF THE RESPIRATORY SYSTEM. gested, and the body cold and covered with sweat. The re- spirations are not rapid, but labored and noisy. Cough is often present and is associated with the expectoration of scanty viscid mucus. On close examination little grayish balls are noted in the sputum, and when unravelled, they are found to be composed of delicate spirals of mucus, which have been moulded in the finer bronchioles (Curschmann's spirals). Curschmann's Spirals, a, Central fibre. Microscopic examination also reveals octahedral crystals similar to those found in leukaemia (Charcot-Leyden crystals). The paroxysms may last from a few minutes to many hours, and may recur for several successive nights, or may disappear entirely for weeks or months. Physical Signs.—Inspection reveals evidences of dyspnoea and distention of the chest. Percussion generally yields hyper-resonance. Auscultation.—A prolonged, high-pitched, wheezing expira- tion, with abundant sonorous and sibilant rales. The expira- tory wheezing may be audible over the entire room. Diagnosis.—Cardiac and renal asthma are to be distin- guished from essential asthma by the history, and by the evi- dence of organic heart or kidney disease. Hay asthma is recognized by the associated coryza and by its periodic occurrence every spring or fall. ASTHMA. 193 Laryngeal obstruction from foreign bodies, croup, paralysis of the vocal cords, or wdema.—The dyspnoea is with inspira- tion, and the chest instead of being distended is retracted, especially at the base. Sequelae. — Emphysema invariably follows when the asthma is of long duration ; it results from the tension to which the vesicles are subjected during the expiratory effort. Dilatation of the right ventricle is also a remote sequel. Prognosis. — The disease does not prove fatal except through complications or sequela?. Iu young persons without an inherited tendency the prognosis should be guardedly favorable; it frequently subsides at puberty. Cases associated with some definite reflex cause, as nasal obstruction, often recover when the latter is removed. The older the patient, the greater the inherited tendency, the more unfavorable becomes the prognosis. Treatment. The Attack.—Prompt relief often follows the inhalation of nitrite of amyl (five or six drops in a glass or on the handkerchief), iodide of ethyl (twenty to thirty drops), or a few whiffs of chloroform. Smoking cigarettes of belladonna and stramonium leaves wrapped in nitre-paper— paper which has been soaked in a saturated solution of salt- petre and dried—will often suffice in mild attacks. Nitre- paper may be burned in the room and the fumes inhaled. The application of dry cups or thin poultices to the chest is often a valuable adjunct to the treatment. Morphia (gr. J-J) with sulphate of atropine (gr. T^) will often cut short an attack. Internally, sedatives like Hoffmann's anodyne (5ss), tincture of lobelia ("I xx), and bromide of potassium (gr. xxx), are sometimes useful. IJ Potass, bromid., ^iij ; Tinct. lobelia?, f^iij ; Spt. a?ther. comp., f.lj ; Ext. grindelia? rob. fl., f3«s ; Syr. sarsaparilla? comp., q. s. ad f§iv.—M. Sig.—A dessertspoonful in water every two hours. The Interval.—Careful search should be made for some re- flex irritation, especially in connection with the naso-pharynx. An easily-assimilable diet must be selected; in nocturnal 13 194 DISEASES OF THE RESPIRATORY SYSTEM. asthma the evening meal should be very light. Graduated ex- ercise and frequent bathing, followed by friction of the skin, will add to the general vigor. A change of climate is de- sirable, but there is no fixed rule in the selection of locality. Many asthmatics do well in the city, but a dry atmosphere and a high altitude are better suited to the majority. Busey claims excellent results from the habitual wearing of an oil- silk jacket in asthma associated with bronchitis. Among the remedies arsenic and iodide of potassium hold a high place as alteratives. Fowler's solution (three drops, gradually increased to ten or more, thrice daily), or five to ten grains of the iodide may be administered over long periods. Nitroglycerin (gr. Tfa), or nitrite of sodium (gr. iij-v thrice daily) often gives immunity for long periods. HAY ASTHMA. (Hay Fever, Autumnal Catarrh, Rose Cold.) Definition.—A catarrhal affection of the respiratory tract, usually occurring periodically every spring or autumn, excited by the action of some atmospheric irritant upon a hyperaes- thetic mucous membrane, and characterized by coryza, bron- chitis, and asthmatic seizures. Etiology.—An inherited tendency, male sex, nervous tem- perament, indoor life, and chronic nasal catarrh are predis- posing factors. The attack as a rule occurs in the autumn (Autumnal catarrh), or in the spring (Rose cold), and is excited by certain dusts, vapors, or odors. The pollen of plants seems to be a common excitant. The seizures may occur at any time if the peculiar irritant is present. Pathology.—An essential feature is the hypersensitive condition of the mucous membrane, and this is often, though not invariably, associated with hypertrophic rhinitis. Symptoms.—Redness of the conjunctiva? and swelling of the eyelids; pruritus of the pharynx, nose, and eyes; sneez- ing ; obstruction of the nostrils; watering of the eyes; a copious discharge of mucus from the nose; headache; cough ; and asthmatic attacks are the usual phenomena. Rose cold usually begins in May or June and runs to the pulmonary emphysema. 195 latter part of July. Autumnal catarrh begins in the latter part of A ugust and ends with the first frost. Prognosis.—The disease runs an indefinite course, and rarely, if ever, proves fatal. Cases which are associated with chronic rhinitis often permanently recover on the removal of the latter. In other cases, the prognosis as regards immu- nity from future attacks is unfavorable. Treatment.—Careful search should be made for chronic nasal disease, and if found, appropriate treatment instituted. A change of climate during the period of susceptibility exempts most patients. A sea-voyage or a sojourn in some high-mountain district, like the White Mountains, Adiron- dacks, Catskills, or Alleghanies may be recommended. Tonics are usually indicated, and quinine, arsenic, and strychnia are often very useful when administered before and during an attack. To allay itching and lachrymation, the eyes may be washed with a solution of boric acid (gr. x to 3j), or sulphate of zinc (gr. i-ij to 3j). Sneezing, nasal fulness, and discharge are often relieved by medicated sprays. A solu- tion of cocaine, or the following may be employed:— IJ Menthol, 3j-3ij ; 01. amygd. dulc. vel benzoinol, f 3*ij-M. Sig.—Spray into the nose and throat every few hours. PULMONARY EMPHYSEMA. Definition.—Abnormal distention of the lungs with air. Varieties.—(1) Interlobular emphysema: This form is rare, and results from the rupture of the lung and escape of air into the interstitial tissue. (2) Compensatory emphysema : When a lung or a part of a lung is disabled from any cause, the healthy portions distend and do vicarious work. (3) Atrophic or senile emphysema: In old people the solids of the lung atrophy, so that a relative increase of air results. (4) Hypertrophic emphysema. The last three varieties are included under the term vesicular emphysema. 196 DISEASES OF THE RESPIRATORY SYSTEM. Hypertrophic Emphysema. Definition.—A pulmonary disease characterized anatomi- cally by dilatation of the air-vesicles and atrophy of the walls; and clinically by dyspnoea, enlargement of the thorax, hyper- resonance, and weak breathing. Etiology.—Congenital weakness of the lung structure— probably a defective development of elastic tissue—is an im- portant predisposing factor. This predisposition may be trans- mitted through several generations. In forced expiration, the air cannot escape with sufficient rapidity through the narrow glottis, and the backward pres- sure stretches the air-vesicles; hence, the obstinate cough of chronic bronchitis, the expiratory straining of asthma, and occupations which necessitate forced expiration, like playing on wind instruments and glass-blowing, are causal factors. Pathology.—The lungs are enlarged, and do not collapse when the thorax is opened. In bad cases the free margins are studded with large bulla? or blebs which have resulted from the rupture of a number of vesicles into a common sac. The organs are pale, and have a soft cotton-like feel. Microscopic examination reveals atrophy of the vesicular walls, a dimin- ished amount of elastic tissue, and more or less obliteration of the pulmonary capillaries. This last condition leads to in- creased tension in the pulmonary artery and to secondary hypertrophy of the right ventricle. Symptoms.—The disease generally manifests itself in middle life, but it is not infrequently observed in the young. Dys- pnoea, increased by exertion; cyanosis, often extreme during attacks of acute bronchitis ; and cough, from the associated bronchitis, are the usual symptoms. In advanced cases dropsy may result from cardiac failure. Physical Signs.—The neck is short, and the sterno- cleido-mastoids prominent. The thorax is likewise short, but broad especially in its antero-posterior diameter. This con- figuration has given rise to the term " barrel-shaped" chest. On respiration there is little expansion, but an elevation of the thorax as a whole. The apex-beat is invisible, but an abnormal pulsation is often noted in the epigastrium. PULMONARY EMPHYSEMA. 197 Palpation.—Diminished vocal fremitus. Percussion. — Increased resonance. The upper level of hepatic dulness is depressed, and the area of cardiac dulness may be almost obliterated. Auscidtation.—Inspiration is short, expiration is prolonged and low-pitched, or inaudible. Pales resulting from the asso- ciated bronchitis are frequently heard. The pulmonary second sound is accentuated. Complications.—Bronchitis, asthma, dilatation of the right ventricle, and later, tricuspid regurgitation and dropsy. Diagnosis. Chronic Bronchitis.—The dyspnoea, thoracic enlargement, hyper-resonance, and prolonged expiration sepa- rate emphysema from bronchitis. Pneumothorax.—This is almost invariably unilateral, the resonance is tympanitic, and metallic tinkling and bell- tvmpany are obtained on auscultation. Prognosis.—The disease is generally incurable; but its advance may be stayed by relieving the primary condition. Emphysema runs a long course and is in itself rarely fatal, but death may result from heart failure and dropsy, or from intercurrent pneumonia. Treatment.—The remedies advocated in chronic bron- chitis and asthma are often applicable here. The patient should be placed under the most favorable hygienic conditions. Iodide of potassium (gr. x thrice daily) is often used empiri- cally, and sometimes relieves the dyspnoea and cough. Iron is indicated in the anaemic. Strychnia (gr. fa—fa) is a valu- able respiratory and cardiac stimulant, and may be combined with digitalis when there are symptoms of heart failure. IJ. Strychnin, sulph., gr. % ; Pulv. digitalis, Pulv. scilla?, Ferri reduct., aa gr. xx.—M. Ft. in pil. No. xx. Sig.—One thrice daily. The inhalation of oxygen, or the inspiration of compressed air followed by expiration into rarefied air is sometimes a useful measure. 198 diseases of the respiratory system. HAEMOPTYSIS. (Bronchorrhagia, Broncho-pulmonary Hemorrhage.) Definition.—The expectoration of blood. Etiology.—(1) Vicarious menstruation (rare). (2) Trau- matism. (3) Inflammatory diseases of the respiratory tract, especially phthisis and pneumonia. (4) The rupture of an aortic aneurism. (5) Obstruction to the venous circulation as in chronic heart and liver disease. (6) Malignant disease of the lung. (7) A dyscrasia of the blood, as in purpura, the infectious fevers, haemophilia (bleeder's disease), and scurvy. (8) It occasionally occurs in young people without obvious cause. Symptoms.—Sometimes the bleeding is preceded by cough, dyspnoea, or substernal warmth or tenderness, but often there is no premonition, and the first indication is the presence of a warm salty fluid in the mouth. The blood is generally raised by coughing, and is bright red and frothy. It is alkaline in reaction, and intimately mixed with air and mucus. The hemorrhage is rarely profuse unless it results from the rupture of an aortic aneurism or the ulceration of a large vessel in ad- vanced phthisis. Auscultation of the chest reveals bubbling rales. The subsequent expectorations are tinged with blood, and if much is swallowed it may excite vomiting or pass into the intestine and impart a tarry appearance to the stools. Diagnosis.—Haemoptysis must be distinguished from haema- temesis :— HAEMOPTYSIS. History of some chest disease. The blood is ejected by coughing. The blood is bright red and frothy. The blood is mixed with sputum. The blood is alkaline in reaction. The subsequent expectorations are tinged with blood, and the stools are rarely tarry. Auscultation reveals rales. HAEMATEMESIS. History of some abdominal dis- ease. The blood is ejected by vomiting. The blood is dark, and dense or clotted. The blood is mixed with food. The blood is acid in reaction. The subsequent expectorations contain no blood, and the stools are frequently tarry. Auscultation gives negative re- sults. PULMONARY APOPLEXY. 199 Prognosis.—Ha?moptysis is rarely the cause of death in the disease in which it occurs. In phthisis the symptoms often improve after a moderate hemorrhage. On the other hand, in aneurism, advanced phthisis, and abscess and gan- grene of the lung, the bleeding may prove fatal. Treatment.—Absolute rest and the avoidance of excite- ment. The shoulders should be elevated ; an ice-bag may be placed on the chest, and pieces of ice may be held in the mouth. and slowly swallowed. Morphia is generally required as a sedative; it may be given hypodermically with ergotin (gr. v-x) or with the fluid extract of ergot (ni x-xx). Gallic acid (gr. x-xx) may be given by the mouth. Astringent sprays are useless. A saline purge may act beneficially by inviting blood away from the congested organ. A firm ligature around one or both legs retards the flow of venous blood, and so aids in arresting the hemorrhage. When the bleeding is not profuse, but frequently repeated, the following internal remedies are efficient: Acetate of lead gr. ij with powdered opium gr. \, gallic acid (gr. x-xx), fluid extract of hamamelis (3j-3nj)> turpentine (gtt. x), or— IJ. Acid, gallic, giiss ; Acid, sulph. aromat., f^j ; Glycerin., f^ss ; Aqua?, q. s. ad f giv—'M. Sig.—A tablespoonful thrice daily. PULMONARY APOPLEXY. (Hemorrhagic Infarction of the Lung.) Definition.—An effusion of blood into the pulmonary tissues. Etiology.—It may result from degeneration of the pul- monary vessels, but it is most frequently due to an embolism in one of the branches of the pulmonary artery. The em- bolism is usually a portion of thrombus which has formed in the heart or in one of the systemic veins. Occlusion of the vessel causes a backward flow of blood, the part becomes en- gorged, and effusion follows. 200 DISEASES OF THE RESPIRATORY SYSTEM. Pathology. — The infarction is usually located in the periphery of the lung; it is conical in shape with its apex pointing inwards. The portion affected is airless, and reveals an infiltration of dark blood. Microscopic examination shows a dense aggregation of blood-corpuscles. If it does not prove fatal, absorption and subsequent fibroid induration result. Symptoms.—AVhen the infarction is large the usual symp- toms are dyspnoea, cough, and the expectoration of dark blood containing few air-bubbles. These symptoms occurring in chronic heart-disease are especially suggestive. Physical Signs.—Very large infarctions give dulness and bronchial breathing. Treatment.—The condition itself is not amenable to treat- ment. Remedies should be directed to the primary disease. CONGESTION OF THE LUNGS. Active Congestion. Etiology.—This results from increased afflux of blood to the lungs. Hypertrophy of the heart, violent exercise, moun- tain-climbing, the inhalation of irritants, and mental excitement occasionally produce it. It is an associated condition in all severe inflammatory diseases of the lungs. In the vast majority of cases it marks the initial stage of croupous pneu- monia. Pathology.—The lung is bright red in color, heavy, and less crepitant. When incised and pressed, copious frothy blood exudes. Symptoms. — Flushed face; dyspnoea; short, dry cough, followed by tenacious blood-streaked expectoration ; and a rapid, full pulse. Physical examination reveals slight dulness, crepitant rales, and broncho-vesicular breathing. Treatment.—Rest; liquid diet; wet cups to the chest, Internally.—Veratrum viride and a saline purge. congestion of the lungs. 201 Passive Congestion. Etiology.—This results from obstruction to the flow of blood from the lungs to the heart. The chief cause is cardiac disease, especially fatty degeneration, dilatation, and mitral disease. Pathology.—The lungs are dark red in color, and often somewhat oedematous. When the condition has lasted a long time, the organs become brown, dense, and tough (brown in- duration). Microscopic examination reveals a dilatation of the capillaries, an overgrowth of connective tissue, free pigment granules, and degenerative changes in the bloodvessels. Symptoms.—Dyspnoea; hard cough ; mucous expectoration containing pigmented cells. Physical examination reveals rales, slight dulness, and feeble breathing. Treatment.—Remedies should be directed to the under- lying cardiac disease. The application of dry cups often gives temporary relief. Saline laxatives may prove useful. Hypostatic Congestion. (Hypostatic Pneumonia, Splenization of the Lung.) Definition.—A congestion of dependent portions of the lungs occurring in asthenic diseases which necessitate a pro- tracted recumbent position. Etiology.—It is generally observed in low fevers and in chronic wasting diseases. (1) Blood-dyscrasia, (2) a weak heart, and (3) a recumbent position are the causal factors. Pathology.—The lungs are dark red and oedematous pos- teriorly. The oedema and increased amount of blood render the organs more solid and less crepitant. They never show the granular appearance of croupous pneumonia. Symptoms.—Dyspnoea, cough, and scanty expectoration. Physical examination reveals slight dulness, subcrepitant rfdes, and feeble bronchial breathing. Treatment.—Efforts should be made to prevent the de- velopment of hypostatic pneumonia in asthenic disease by frequent change of position, and the timely use of such cardiac 202 diseases of the respiratory system. stimulants as alcohol, strychnia, digitalis, ammonia, and tur- pentine. When already present, turpentine stupes or dry cups may be applied externally, and one or more of the above stimulants administered internally. CROUPOUS PNEUMONIA. (Lobar Pneumonia, Pneumonitis, Lung Fever.) Definition.—An acute specific disease, characterized ana- tomically by an inflammation of the lungs, followed by a rapid infiltration of their alveoli; and manifested clinically by high fever, cough, dyspnoea, "rusty" sputum, and physical signs indicative of consolidation. Etiology.—Age, sex, and climate exert but little predis- posing influence. Lowered vitality from bad hygiene or from some pre-existent disease, like diabetes, Bright's disease, or one of the infectious fevers, favors its development. * One attack renders the patient more liable to subsequent infection. Alco- holism is a strong predisposing factor. Exposure to cold and wet often precipitates the attack. The exciting cause is unquestionably a microorganism, pro- bably Frankel's diplococcus pneumonia?. Pathology.—Anatomically three stages have been recog- nized : (1) The stage of congestion ; (2) of red hepatization ; (3) of gray hepatization. Stage 1.—The affected portion remains distended when the chest is opened; it is of a deep-red color, and is more resistant to the touch than the normal lung. On section, a frothy blood- stained serum freely exudes. Microscopic examination reveals a dilated and tortuous condition of the capillaries, swelling of the alveolar cells, and a slight corpuscular exudate. Stage 2.—The hepatized portion is increased in volume, is quite firm, is of a dark-red color, and so heavy that it sinks in water. It is very friable, and the torn surface presents a granular appearance from the projection of the fibrinous plugs in the alveoli. Microscopic examination reveals a mesh of coagulated fibrin enclosing numerous red blood-corpuscles and some leucocytes • CROUPOUS PNEUMONIA. 203 the latter are also noted in the interlobular tissue. In sections properly treated the diplococcus is detected. Stage 3.—The red color gives place to a mottled gray, and the solidified lung begins to soften. The change in color is due to the compression of the capillaries, to the disappearance of red corpuscles and their replacement by leucocytes, and to fatty degeneration of some of the elements. In favorable cases resolution occurs before gray hepatization has far advanced, the exudation being removed by absorption and expectoration. In unfavorable cases the consolidated lung may become in- filtrated with pus (Purulent infiltration); it may become gangrenous; or, very rarely, it may become the seat of fibroid induration (Chronic interstitial pneumonia). Death may result early in the disease from the generated blood-poisons, or from rapid diminution of the respiratory surface. The consolidation usually begins at the base and extends upwards. The most frequent seat is the lower lobe of the right lung. The bronchi and the adjacent pleura are involved in the inflammatory process. Symptoms.—The disease usually begins with a decided chill and a sharp pain in the side, followed by a rapid rise of temperature; the latter often attains its maximum (104°-105°) in twenty-four hours, and generally continues high, with slight diurnal remissions, until the ninth day, when it falls by crisis, frequently reaching the norm by the tenth day. Occasionally the temperature falls by lysis. There is marked dyspnoea; the respirations are shallow and rapid, ranging from 40 to 80 per minute, thus making the ratio between respiration and the pulse 1 to 3 or 1 to 2. Cough is a prominent symptom ; at first it is short and dry, but later it is accompanied by bloody (" rusty"), translucent, and tenacious sputa. Microscopically the sputum contains red blood-corpuscles, their free pigment, pus-corpuscles, diplococci, and other microorganisms. The face is flushed; the lips are cvanosed and often the seat of an herpetic eruption ; the tongue is heavily furred; the bowels are constipated; and the urine is scanty, high-colored, de- 204 DISEASES OF THE RESPIRATORY SYSTEM. ficient in chlorides, and often slightly albuminous. In severe cases delirium is rarely absent. Physical Signs. Inspection.—Diminished expansion, but no bulging of the interspaces or displacement of the apex-beat. Palpation. — Diminished expansion and increased vocal fremitus. Percussion.—At the onset there may be tympany over the affected area from diminished intra-pulmonary tension. As consolidation advances the note becomes remarkably dull. Exaggerated resonance is noted around the hepatized areas. Auscultation.—In the stage of congestion fine crepitant rales are heard at the end of forced inspiration; they probably result from the forcible separation of adherent vesicular walls, and disappear when the lung becomes solidified. Auscultation then detects increased vocal resonance, and harsh breathing which is prolonged, high-pitched, and tubular in expiration (bronchial). During resolution the softened exudate produces fine moist rales—the redux-crepitus. Atypical Cases. Senile Pneumonia.—The symptoms often develop insidiously; the temperature may not be high ; the pulse may not be accelerated; expectoration is often absent; the signs are not marked; delirium is common; weakness is extreme; and death from exhaustion is the most frequent termination. Pneumonia in Children.—It is often ushered in with con- vulsions. Headache, delirium, stupor, and coma are promi- nent symptoms, so that the disease may simulate meningitis. The temperature is very high; expectoration is often absent. The disease frequently begins at the apex of the lung. Typhoid Pneumonia.—Pneumonia associated with typhoid symptoms, — headache, muttering delirium, stupor, a dry, brown tongue, subsultus tendinum, carphologia, a rapid, weak pulse, and high fever which, in favorable cases, falls by lysis. The expectoration is often like prune-juice. Pneumonia of Drunkards.—The onset is gradual; the ex- pectoration is like prune-juice; the temperature is not high, but a violent maniacal delirium commonly develops and is followed by death from exhaustion. CROUPOUS PNEUMONIA. 205 Complications.—Pleurisy, pericarditis, endocarditis, oedema of the lungs, delayed resolution (consolidation may last five or six weeks, and then disappear), abscess of the lung, gangrene of the lung, and chronic interstitial pneumonia. Diagnosis. Pleurisy.—Here the initial chill is not so marked ; the fever is not so high nor the pulse so rapid ; and there is no " rusty" sputum ; but bulging and displacement of the apex-beat are often noted on inspection ; the percussion-dul- ness may change with the posture of the patient; vocal reso- nance and vocal fremitus are diminished; and the breathing is distant and weak. Acute Phthisis.—Irregular fever, bacilli in the sputum, and the continuation of grave symptoms with signs of softening after the ninth or tenth day, will suggest the diagnosis of tuber- culosis. Pulmonary (Edema.—Here there is absence of chill, fever, and pain; the expectoration is watery, not "rusty;" both lungs are commonly affected ; auscultation reveals abundant subcrepitant rales and weak breathing. Typhoid Fever.—Typhoid pneumonia may be readily mis- taken for typhoid fever with pneumonia; but pneumonia as a complication occurs late in the disease, so that the history of the onset gives much assistance. The rose-red rash will indicate typhoid fever. Prognosis.—In patients previously healthy, the prognosis is good. At the extremes of life the outlook is grave. In drunkards the disease is especially fatal. In individual cases, a very high fever, great dyspnoea and cvanosis, rapidly increasing consolidation, involvement of both lungs, and a dark sputum are unfavorable factors. The average mortality is 20 per cent. _ Treatment.—Absolute rest. A liquid or semi-liquid diet (milk, koumiss, eggs, broths, beef juice). The chest should be enveloped in a cotton jacket covered with oiled silk. Although pneumonia is an infectious disease which produces widespread disturbance in the economy, the immediate danger is generally obstruction to the pulmonary circulation ; so that in the stage of congestion, when the pulse is full and strong, veratrum viride ("i iij-v of the fluid extract every hour until 206 DISEASES OF THE RESPIRATORY SYSTEM. the pulse softens) is a valuable remedy. It depresses the heart, dilates the systemic vessels, and so invites blood away from the engorged lung. In the very robust, venesection may be substituted for veratrum. In consolidation, the right ventricle is subjected to a strain and there is danger of heart failure; hence cardiac stimulants are indicated in this stage. The tincture of digitalis (gtt. x every two or three hours, being guided by the pulse) may be given by the mouth; when the stomach is irritable, the drug should be administered hypodermically. Strychnia (gr. fa) is also of great value as a cardiac and respiratory stimulant. Ammonia is useful in some cases, and either the aromatic spirits or the carbonate may be employed. In mild cases quinine (gr. v thrice daily) will be the only internal remedy required. As a general stimulant and food, alcohol is often indicated. In typhoid pneumonia turpentine ("I v) may be associated with the alcohol. Pain may be relieved by opium, or by the application of wet cups, dry cups, or hot fomentations. Delirium.—Apply an ice-bag to the head, and administer bromide of potassium, hyoscine, musk, or camphor internally. When the delirium is associated with high fever, a cold pack or tepid bath will often control it. Pyrexia.—Occasionally, high fever will require treatment; sponging, a cold pack, or a cold bath (80°) may be employed. Antipyrin (gr. vj) is a safe and efficient remedy. Convalescence should be guarded, and such tonics as iron, quinine, strychnia, and cod-liver oil will be found useful resto- ratives. In delayed resolution, small blisters may be applied over the affected areas, and iodide of potassium may be administered internally. Thus :— Potass, iodid., gj ; Ammon. chlor., giss ; Mist, glycyrrhiza? comp., f^vj.—M. (Da Costa. ) Sig.—Tablespoonful four times a day. CATARRHAL PNEUMONIA. 207 CATARRHAL PNEUMONIA. (Broncho-pneumonia, Lobular Pneumonia, Insular Pneumonia.) Definition.—An inflammation of the terminal bronchioles and air-vesicles, characterized anatomically by scattered areas of consolidation which are composed almost entirely of leuco- cytes and desquamated epithelium; and manifested clinically by moderately high and irregular fever, dyspnoea, cough, and physical signs indicative of insular consolidation. Etiology.—The disease is generally secondary to bronchitis, and the causes which predispose to an extension of the inflam- mation from the bronchi to the air-vesicles are: Childhood and old age; the infectious fevers, especially measles, whoop- ing-cough, diphtheria, and influenza; and low vitality. Another group of cases results from the aspiration of mucus, pus, or particles of food into the smaller bronchi. This is liable to occur from any cause which renders expectoration im- perfect, as the coma of apoplexy, the stupor of typhoid fever, bulbar palsy, tracheotomy, and advanced paretic dementia. Pathology.—As a rule, both lungs are involved. On section, small projecting areas of consolidation are noted here and there around the finer bronchioles. Recent patches are reddish-brown in color, firm, and smooth or finely granular ; later they become grayish and soft. The terminal bronchi are filled with purulent material. In addition to these solidified areas, there are other small patches of collapsed lung which are airless, firm, and bluish- red in color. The collapse has resulted from occlusion of the bronchus, and closely resembles consolidation ; but it can, as a rule, be overcome when inflation is practised by means of a blowpipe inserted in the supplying bronchus. Microscopic examination reveals an exudate in the terminal bronchi and air-cells, which is composed of leucocytes and des- quamated epithelium in various stages of degeneration. The walls of the bronchi are also infiltrated with leucocytes. When compared with croupous pneumonia, the contrast is striking. In the latter the lung is involved en masse ; the con- solidation is distinctly granular, and is composed of red blood- 208 DISEASES OF THE RESPIRATORY SYSTEM. corpuscles, white blood-corpuscles, fibrin, and diplococci; the lining epithelium is but slightly involved ; and the walls of the bronchi are not infiltrated with leucocytes. Terminations.—(1) Resolution ; the exudate undergoes fatty degeneration and is removed by absorption or expectora- tion. (2) Tuberculosis. Termination in phthisis is quite com- mon ; doubtless in many cases the disease was primarily tuber- culosis, and in others the exudate became a good soil for the development of tubercle bacilli. (3) Abscess or gangrene; these terminations are rare except in pneumonias resulting from aspiration. • Symptoms.—The symptoms are often masked by the pri- mary disease. The onset is usually gradual, and is character- ized by prostration, cough, and fever. The last is moderately high and very irregular (101°-104°). The dyspnoea is marked, and the respirations are rapid—50 to 80 per minute ; the pulse is greatly accelerated—120 to 180 per minute; cough is painful and accompanied by a muco-purulent ex- pectoration which is rarely blood-streaked. The face is usu- ally pale and anxious, and the lips blue. Physical Signs.—As the areas of consolidation are gene- rally small and scattered, the physical signs are not marked. Inspection reveals evidences of dyspnoea,—lividity, playing of the nostrils, prominence of the sterno-cleido-mastoids, and retraction of the base of the chest. Palpation usually gives negative results. Percussion may reveal areas of dulness in one or both lungs. Auscultation reveals fine sibilant (whistling) or subcrepitant rales, and areas over which the breathing is tubular, or bron- chial. Diagnosis.—The following table will show the clinical differences between catarrhal and croupous pneumonias:— CATARRHAL PNEUMONIA. 209 Cause . . . Onset . . . Fever . Expectoration Physical Signs Catarrhal Pneumonia. Usually secondary to bron- chitis. Gradual, a chill generally absent. Moderately high, very ir- regular, and ending by lysis after an indefinite period. Muco-purulent. A bilateral disease. Phy- sical signs are indistinct and indicate scattered areas of consolidation. Croupous Pneumonia. A primary disease excited by the diplococcus. Abrupt onset with a chill. High, regular, and ending by crisis at the eighth or ninth day. " Rusty," translucent, and tenacious. A unilateral disease. Phy- sical signs are distinct and indicate a large and uniform consolidation. Acute Phthisis.—In this disease there is a tuberculous broncho-pneumonia which is difficult to distinguish from sim- ple broncho-pneumonia. A family history of tuberculosis, an extensive involvement of the apices, bubbling rales indicating softening, long duration, and bacilli and elastic fibres in the sputa are the diagnostic phenomena of phthisis, Bronchitis.—In simple bronchitis the fever is not high, the dyspnoea is rarely marked, prostration is usually absent, and there are no physical signs indicating consolidation. Capillary Bronchitis always precedes catarrhal pneumonia, and the diagnosis of the two is often impossible. The absence, in the former, of physical signs indicating consolidation is the only diagnostic factor. Prognosis.—Always guarded. In the very young, very old, and debilitated the disease is commonly fatal. Many recover from the pneumonia following the infectious fevers. Aspiration-pneumonia is commonly fatal. The mortality is difficult to estimate, for acute phthisis is often diagnosed catarrhal pneumonia; it is probably greater than in croupous pneumonia, and varies from 30 to 60 per cent. The duration is from one to three weeks; a longer duration would suggest tuberculosis. Treatment.—The disease can often be prevented by care- fully protecting patients suffering from bronchitis and infec- 14 210 DISEASES OF THE RESPIRATORY SYSTEM. tious fevers. In the latter it is also essential that the naso-pha- rynx should be kept clean with some mild antiseptic solution. The room should be well ventilated, but free from draft, and the temperature should be kept uniformly at 70°. A moist atmosphere is desirable, and an apparatus for producing steam may be improvised. Tincture of iodine may be applied locally, and the chest enveloped in a cotton jacket. The diet should be liquid or semi-liquid, and may include milk, junket, koumiss, eggs, broths, and beef-juice. Stimu- lants, wine or brandy, are usually required to combat the extreme prostration. At the onset a laxative should be administered, and calomel may be selected (gr. ^ every hour until it operates). Stimulating expectorants are nearly always indicated, and chloride of ammonium, carbonate of ammonium, squills, or senega may be employed. fy Amnion, chloridi, gr. 1; Spt. retheris nitrosi, fgss ; Syr. senegse, fgiiss ; Tinct. cardamom, comp. et aquae, aa q. s. ad f ^ij. —M. Sig.—A teaspoonful every two or three hours to a child of three years. Or— I£ Ammon. carb., gr. xxiv ; Syr. tolu., f^vj ; Spt. vini gal., f 3 iij ; Syr. senegse, f ^iijss ; Syr. acaciae, q. s. ad f§iij.— M. (Goodhart and Starr.) Sig.—Teaspoonful every two hours to a child of two or three years. Strychnia is often invaluable as a respiratory and cardiac stimulant; for an adult, gr. -fa may be given three or four times daily. The accumulation of mucus in the bronchial tubes, indicated by extreme cyanosis, a weak pulse, and bubbling rales, will call for an emetic; wine of ipecac (5j-|ss), or apomorphia (for an adult gr. fa) may be selected. Nervous symptoms— restlessness, delirium, etc.—will often be relieved by a cold pack or by a cold bath. Hyoscine, bromide of potassium, or CHRONIC INTERSTITIAL PNEUMONIA. 211 chloral in small doses may be required. In children the fol- lowing suppository is often very efficient:— J$l Pulv. asafcetidae, 3']; Quininse sulph., gr. xxx ; 01. theobromatis, q.s.—M. (Pepper.) Ft. in suppos. No. xii. (Child's size.) Sig.— One every three or four hours for a child of five years. In delayed resolution counter-irritants should be applied to the affected areas, and iodide of potassium should be adminis- tered internally. Convalescence must be guarded; tonics like cod-liver-oil, iron, arsenic, and hypophosphites are useful restoratives. A change of scene is desirable. CHRONIC INTERSTITIAL PNEUMONIA. (Cirrhosis of the Lung, Chronic Pneumonia, Pulmonary Induration.) Definition.—A chronic disease of the lung, characterized by an overgrowth of fibrous tissue. Etiology.—It is a rare sequel of croupous pneumonia. It is commonly found associated with tubercles in fibroid phthisis. The overgrowth of connective tissue is sometimes induced by an old fibrinous pleurisy. It may be au expression of syphilis. It arises primarily from the constant inhalation of irritating dusts, as stone-dust (Chalicosis), coal-dust (Anthracosis), metal-dust (Siderosis). Pathology.—When the thorax is opened the lung is found retracted and the heart displaced. The organ is tough, firm, and more or less airless. Section shows au overgrowth of fibrous tissue, and usually inflammation and considerable dila- tation of the bronchi. Symptoms.—Moderate dyspnoea and chronic cough; the expectoration may be slight, but often it is profuse, and fetid from having been retained in bronchiectatic cavities. There is no fever, and the general health may be well preserved for many years. Physical Signs. — Inspection reveals retraction of the affected side and displacement of the apex-beat. 212 DISEASES OF THE RESPIRATORY SYSTEM. Percussion often yields dulness; but over saccular dilata- tions of the bronchi there may be hyper-resonance. Auscultation. — The vocal resonance is increased and the breathing is often bronchial or cavernous. Diagnosis. Fibroid Phthisis.—Involvement of both lungs, bacilli in the sputa, and fever would indicate fibroid phthisis. Prognosis.—Incurable. The duration is from ten to twenty years. Treatment. — Palliative. It consists in good hygienic regulations and the use of remedies directed to the bronchi- ectasis. GANGRENE OF THE LUNG. Definition.—A putrefactive necrosis of the lung. Etiology.—Gangrene is not a primary condition, but is secondary to some inflammatory disease of the lung. It is ex- cited by the entrance of bacteria of putrefaction, but unless the system is considerably reduced in vitality the tissues, even though diseased, show wonderful resistance, and escape putre- faction. Pneumonia, especially aspiration-pneumonia, phthisis, pres- sure of morbid growths, bronchiectasis, abscess, and hemor- rhagic infarction following embolism of the pulmonary artery are the predisposing, pulmonary conditions; and Bright's dis- ease, alcoholism, the infectious fevers, and particularly diabetes, by lowering the vitality, render these conditions operative. Pathology.—The process may be circumscribed or diffuse, most frequently the former. The affected part is converted into a greenish-black, soft mass, having an extremely fetid odor. When the softened material has been expectorated there is left behind a cavity with ragged walls, containing a foul-smelling liquid. The tissues around the cavity are inflamed and oede- matous. Symptoms.—The symptoms of gangrene are associated with the original disease. Cough, dyspnoea, moderate fever, and great prostration are generally present. The expectoration is characteristic; it is profuse, and has a penetrating offensive odor. When allowed to stand in a glass ABSCESS OF THE LUNG. 213 vessel it separates into three layers: a frothy layer on top, a serous layer in the middle, through which hang strings of pus, and at the bottom a layer of reddish-green purulent material. Altered blood may give it the appearance of prune-juice. Microscopically it contains shreds of tissue, crystals of fatty acids, crystals of haematoidin, and all sorts of bacteria. Physical examination may reveal bubbling rales, and later cavernous breathing, pectoriloquy, and localized tympany on percussion. Prognosis.—Grave. Death usually results from exhaus- tion, but occasionally from hemorrhage or pyo-pneumothorax. Treatment.—Nutritious food, and quinine, strychnia, and alcoholic stimulants will be required to support the system. The offensive odor of the breath may be destroyed by car- bolic acid (gr. j every four hours) internally, or by inhalations of carbolic acid or creasote. Turpentine ("Lv every three hours) has been recommended as a stimulant and antiseptic. When the patient's strength will permit, surgical interference offers the best chance of cure. ABSCESS OF THE LUNG. Definition.—Circumscribed suppuration of the lung. Etiology.—(1) It is rarely a sequel to pneumonia. (2) Multiple abscesses are often embolic, and result from pyaemia. (3) Foreign bodies in the lungs—something swallowed or an hydatid cyst—may excite suppuration. (4) External abscesses sometimes rupture into the lung, as an empyema, hepatic ab- scess, or suppurating mastitis. Symptoms.—High and irregular fever, rigors, sweats, and pallor indicate suppuration. Dyspnoea, cough, and purulent offensive sputa containing shreds of lung tissue are the pul- monary symptoms. Physical examination may reveal bub- bling rales, and later, cavernous breathing and pectoriloquy. Multiple embolic abscesses are rarely recognized during life. Prognosis.—Many cases following pneumonia and the rupture of external abscesses into the lung recover. Embolic abscesses generally prove fatal. 214 DISEASES OF THE RESPIRATORY SYSTEM. Treatment.—Nutritious food and quinine, strychnia, and alcoholic stimulants will be required to support the system. The abscess should be opened and drained, as the pleural sac is in empyema. (EDEMA OF THE LUNGS. Definition.—An effusion of serous fluid into the air- vesicles and into the interstitial tissue of the lungs. Etiology.—Pulmonary oedema is a common cause of death in many acute and chronic diseases which end by heart- failure and the accumulation of blood in the lungs. It is frequently noted in the course of Bright's disease and cardiac disease. A local pulmonary oedema is often found around pulmonic consolidations, abscesses, and infarctions. Pathology.—The lungs, especially the dependent portions, are heavy, red in color, and boggy to the feel. When the affected portion is incised and pressure is made, an abundant blood-stained, frothy serum exudes. Symptoms.—Extreme dyspnoea; rapid, labored breathing ; cough with frothy, blood-stained expectoration; cyanosis; and cold extremities. Physical Signs. Inspection reveals evidences of dyspnoea— sitting posture and prominence of the auxiliary muscles of respiration. Percussion.—Dulness over the bases. Auscultation.—Feeble respiratory murmur; subcrepitant or bubbling rales. Diagnosis. Pneumonia.—The absence of chill, of fever, of " rusty" tenacious sputa, of pain, and of signs indicating consolidation will indicate oedema. Capillary Bronchitis.—The fever and muco-purulent expec- toration will serve to distinguish bronchitis from oedema. Prognosis.—Always grave. It is often a final svmptom of some pulmonary disease. When not advanced, and the conditions are favorable, recovery may follow. Treatment.—When there is much cyanosis, and the patient's strength will permit it, the application of wet cups PULMONARY COLLAPSE. 215 to the chest or bleeding from the arm is of great value. Hot fomentations should be applied to the chest. Hydragogue cathartics are indicated. Epsom salts in concentrated solu- tions, or elaterium (gr. |), may be selected. Cardiac stimulants like ether, alcohol, ammonia, digitalis, and especially strychnia, are required, and may be given hypodermically. r£ Strychnin, sulph.. gr. j ; Aqua? destillat., fgj. Solve et sig.—15 minims hypodermically every three or four hours. Caffeine is a useful diuretic, and cardiac and respiratory stimulant. ty. Catfein., 3j ; Sodii benzoat., 3jss.—M. Ft. in chart. No. xii. Sig.—One every two or three hours PULMONARY COLLAPSE. (Atelectasis.) Definition—An absence of air from a portion of the lung. Etiology.—It may be congenital and result from deficient respiration; in these cases the dependent portions of both lungs are commonly affected. Acquired atelectasis results from occlusion of a bronchus by a foreign body or a plug of mucus, as in capillary bronchitis; or from compression of the lung by a tumor or pleural effusion. Symptoms.—When a large area is collapsed in some pre- existing disease like capillary bronchitis, there is an abrupt increase in the dyspnoea and cyanosis, without a corresponding rise of temperature. Physical examination gives negative results except over extensive collapse, which may give dulness on percussion and weak breathing on auscultation. Prognosis.—This depends upon the extent of collapse and the gravity of the pre-existing disease. Treatment.—In congenital atelectasis apply alternately hot and cold sponges to the spine; keep up the external tem- perature. If these measures fail, gently inflate the lung with a catheter. In the acquired varieties direct remedies to the original 216 DISEASES OF THE RESPIRATORY SYSTEM. disease. Administer cardiac and respiratory stimulants like ammonia, and produce emesis with ipecac or alum. PULMONARY TUBERCULOSIS. (Phthisis, Pulmonary Consumption.) Definition.—A specific inflammatory disease of the lungs, caused by the bacillus tuberculosis; characterized anatomically by a cellular infiltration which subsequently caseates, softens, and leads to ulceration of the lung tissue; and manifested clinically by wasting, exhaustion, fever, and cough. Etiology.—(1) Residence in low, damp, and badly-drained localities. (2) Heredity (important). (3) Age; all ages, but especially between twenty and thirty years. (4) Occupations which necessitate the breathing of impure air and the inhala- tion of irritants like coal-dust, stone-dust, iron-filings, etc. (5) Catarrhal inflammation and traumatism of the lungs. (6) Physique. (7) General diseases which lower the vitality, as diabetes, hepatic cirrhosis, and typhoid fever. The exciting cause is the bacillus tuberculosis, which gains entrance (1) by direct parental transmission (very rare); (2) by inhalation, the dust of dried sputum being commonly the medium of contagion ; (3) through infected food, as the milk and meat of tuberculous cattle. Varieties. — (1) Chronic ulcerative phthisis. (2) Acute phthisis. (3) Fibroid phthisis. Pathology.—The bacillus tuberculosis is a very minute rod, about one-fourth or one-half as long as a red blood- corpuscle, and often slightly bent and beaded. Its detection depends on the power of the stained bacillus to resist the de- colorizing effects of acids. For satisfactory examination a one-twelfth oil-immersion lens is required. The lodgment of bacilli in the terminal bronchioles of the apex excites a proliferation of the fixed cells, which become more or less polygonal in shape. The new cells are termed epithelioid, and frequently contain bacilli. Giant cells are often formed by a fusion or overgrowth of these cells. This aggregation of new cells acts as an irritant and is soon surrounded by a wall of leucocytes, the whole forming a gray, PULMONARY TURERCULOSIS. 217 translucent mass—the gray tubercle of Laennec. In a short time the bacilli excite a coagulation-necrosis which starts in the centre, spreads to the periphery, and converts the tubercle into a yellow, cheesy mass—the yellow tubercle of Laennec. The degenerated tubercles fuse and form the uniform cheesy masses so commonly observed at the autopsy. At this stage one of two things may occur: The mass may soften, break into a bronchial tube, and leave behind a cavity with ulcerat- ing walls, or it may become encapsulated by an overgrowth of connective tissue and subsequently calcified. In addition to the specific process other secondary changes are noted. The lung tissue in the neighborhood of the tuberculous deposits is often the seat of a true pneumonic inflammation; the connective tissue is always more or less proliferated; the bronchial tubes are inflamed; and the pleurae over the affected areas are nearly always adherent. Chronic ulcerative phthisis usually begins at the apices. Acute phthisis has been termed phthisis florida, cheesy pneu- monia, and chronic catarrhcd pneumonia, but the process is invariably tuberculous. From extreme vulnerability of the tissues a lobe or whole lung, or even both lungs, are rapidly infiltrated, and death results in from a few weeks to a few months. In some cases the lung is solidified by a dense yellowish- gray infiltration composed of closely-aggregated tubercles; in others the consolidation appears in more or less discrete patches which have had their origin in the smaller bronchial tubes; in a third form one or both lungs are stiidded with discrete tubercles, many of which are still gray and trans- lucent. In fibroid phthisis the tissues appear to be resistant, and the process is limited by an overgrowth of connective tissue which forms dense bands around the tuberculous foci. This form lasts many years. Chronic Ulcerative Phthisis. Symptoms.—The onset is usually insidious and marked by pallor, gastric disturbance, loss of flesh and strength, and by a dry, hacking cough which is especially noted in the morning. From some undue ex- posure, the cough is often aggravated, and to this obstinate 218 DISEASES OF THE RESPIRATORY SYSTEM. "cold" the disease is usually attributed. In some cases, the symptoms appear abruptly with hemorrhage or an acute pleurisy. Slight fever and acceleration of the pulse are early symptoms of great diagnostic import. The temperature is marked by an evening exacerbation, during which the face is flushed, the eyes bright, and the mind animated. As the disease ad- vances the cough becomes troublesome and the expectoration more abundant. In well-developed cases the expectoration is greenish in color, is in coin-shaped plugs (nummular), is heavy and sinks in water, is often blood-streaked, and on microscopic examination is found to contain bacilli and fibres of elastic tissue. Phthisis is in itself not a painful disease, but the associated dry pleurisy often causes much suffering. Haemoptysis occurs at all stages, but the profuse hemorrhages occur late. The blood is bright red in color, frothy, and mixed with mucus. Dyspnoea is not a marked symptom, and its absence is doubt- less due to the gradual development of the disease. Profuse sweating during sleep is a troublesome feature of advanced phthisis. The final stage is characterized by extreme emaciation, weakness, pallor, high remittent or intermittent fever, and oedema of the feet. The mind is usually clear, and peculiarly hopeful to the end. Physical Signs. Inspection.—The chest is usually long and flat ; the spaces above and below the clavicles are sunken ; the scapulae are prominent; and the ribs are oblique. There may be flattening or less expansion over one apex. Palpation.—Diminished expansion and increased vocal fre- mitus. Percussion.—Dulness, as a rule ; this is noted earliest above or below the clavicles, in the supraspinous fossae, between the scapulae, or in front near the sternal border. A cavity, or vomica, yields tympany, or a " cracked-pot" resonance. The latter can be more clearly demonstrated when the ear is placed near the patient's open mouth. Auscultation.—In the early stage respiration may be inaud- ible over the affected area. Later the breathing is harsh PULMONARY TUBERCULOSIS. 219 and the expiration prolonged and high-pitched (bronchial). The vocal resonance is increased. Crackling rales are usually audible, and are produced by liquid in the small tubes. If not present, coughing will usually develop them. Ausculta- tion over cavities may detect cavernous or amphoric breathing, pectoriloquy, and large gurgling rales. Anomalous Physical Signs.—The vocal fremitus is diminished when there is much pleural thickening. Normal resonance or hyper-resonance may replace dulness when there is much emphysema between small tuberculous foci. Weak breathing may replace bronchial or cavernous when the tubes or cavity are filled with muco-pus. The signs of cavity are sometimes produced by consolidation in the neighborhood of a large bronchus. Acute Phthisis.—Clinically this form resembles pneumonia, and is marked by a chill, high fever, rapid pulse, dyspnoea, sputum at first rusty and then purulent, flushed face, profuse sweats, and the signs of consolidation. Instead of ending by crisis at the eighth or ninth day as an ordinary pneumonia, the symptoms grow rapidly worse, signs of softening appear, the sputum shows bacilli and elastic fibres, and death results in from a few weeks to a few months. Fibroid Phthisis.—This is a disease of long duration. It is characterized by very gradual loss of flesh and strength and by an abundant muco-purulent expectoration, which is at times fetid from being retained in dilated bronchi. Dyspnoea, sweating, and fever are slight. There is very marked retrac- tion on the affected side from the shrinking of the fibrous tis- sue ; with this exception the physical signs are similar to those of ulcerative phthisis. Complications of Phthisis.—Haemoptysis; pneumonia ; pleurisy; pneumothorax; stomatitis; obstinate vomiting induced by cough; diarrhoea; amyloid degeneration of the viscera; fistula in ano (tuberculous); and secondary tuberculosis of other organs, especially the larynx, cerebral meninges, and peritoneum. Diagnosis.—Fever, cough, emaciation, signs of consolida- tion, bacilli and elastic fibres in the sputum are the diagnostic phenomena. 220 DISEASES OF THE RESPIRATORY SYSTEM. Prognosis.—Generally unfavorable, though the disease is not incurable. The accidental discovery of calcified tubercles at autopsies furnishes abundant evidence of spontaneous cure. Many improve and a few recover under well-directed treatment. A strong hereditary tendency, a bad physique, high fever, advanced consolidation, involvement of both lungs, even if slight, unfavorable surroundings, and, it might be added, a slender purse, render the prognosis extremely grave. Treatment. Preventive. — Recognizing the infectious nature of the disease, the following prophylactic measures should be observed : Sputa of consumptives should be received in suitable vessels containing antiseptic solutions, and subse- quently destroyed. Cattle should be rigidly inspected, and tuberculous meat, and milk of tuberculous cows declared un- marketable. Phthisical mothers should not nurse their off- spring. The healthy should not sleep in apartments occupied by those affected. Personal Hygiene.—Good food, fresh air, frequent bathing, avoidance of exposure, graduated exercise, residence in an elevated locality, a dry, well-ventilated house, and plenty of sleep and recreation. Curative Treatment.—This involves two objects : (1) The strengthening of the patient's vitality and resisting power. (2) The destruction or disabling of the tubercle bacilli. General Health.—The diet should be carefully regulated. Nutrients like cod-liver oil (3ij—3iv two hours after meals), malt, and hypophosphites are often very useful. Mineral acids and bitters may be required to stimulate digestion. Iron, quinine, and arsenic are sometimes indicated ; the last, when wrell borne, often exerts a decidedly favorable influence. Alco- hol in many cases is of great value, but the danger of inducing the habit must be borne in mind. Beer, porter, ale, and wine are usually the most desirable preparations. So long as alcohol stimulates the appetite, lowers the temperature, and strengthens the pulse it does good. Its results should be carefully noted, and any untoward effects will call for its immediate withdrawal. Change of Climate.—This offers to many patients the greatest hope of cure. As a rule, a high altitude should be selected; the atmosphere should be dry and the temperature PULMONARY TUBERCULOSIS. 221 equable. Personal experience must decide the question of temperature; generally, patients who feel better in summer will do well in a warm climate, and vice versa. The physician should have some knowledge of the locality, which should afford ordinary conveniences, without being too crowded with sufferers similarly afflicted. In selected cases, a sea voyage is often very useful. Accord- ing to Douglas Powell, it is most suitable to patients in the early stages, who have been previously healthy, who have overworked nervous systems, and in whom the disease is more or less quiescent. Patients in advanced phthisis should not be sent far from home. Specific Treatment.—The injection of iodine, carbolic acid, etc., into phthisical lungs, as recommended by Mosler, Thomp- son, and Pepper, has not given encouraging results. The rectal injection of sulphide of hydrogen, as recommended by Bergeon, has fallen into disuse. Koch's tuberculin has, for the most part, been negative or deleterious in its effect. Of all the special remedies, creosote alone continues to hold its prominent position in the therapy of phthisis. It may be given in pill, in emulsion of cod-liver oil, or with wine. fy_ Creosoti, Ttlxv; Olei morrhuae, f^iij ; Calcii et sodii hyposphos., 3ss; Olei gaultheria?, Iftxx; Acaciae, q. s. Aquae, q. s. ad fgyj.—M. Sig.—A tablespoonful two hours after meals. Or— I£ Creosoti, Tfl.xv; Tinct. gentian., TTLxij ; Spt. vini rect., f^vj ; Vini xerici, fgyj.—M. (Fraentzel.) Sig.—A teaspoonful thrice daily. Creosote is often valuable in inhalations. I£ Creosoti, Spt. chloroformi, Alcoholis, aa f^ss.—M. Sig.—Ten to twenty drops in the inhaler several times daily. 222 DISEASES OF THE RESPIRATORY SYSTEM. Symptomatic Treatment Cough.—Syrups should be avoided as far as possible, and cough alleviated by inhalations of wine of ipecac, creosote, benzoin, or terebene. Tar, terebene, and eucalyptus may be employed internally. Cough associated with the expectoration of much offensive material should not be checked. A cold bed often leads to cough and a wakeful night ;^ in these cases the bed should be warmed before it is occupied. Hot applications to the chest and a hot drink on retiring sometimes insure rest. The following mixture is very efficient in the cough of phthisis :— ]£ Codeinse sulph., gr. iv ; Acid, hydrocyanic, dil., ITLxxxij ; Syr. tolu., fgij.—M. (Da Costa.) Sig.—A teaspoonful three or four times daily. Sweating.—Atropine (gr. jfo), picrotoxin (gr. fa-fa), gallic acid (gr. x), camphoric acid (gr. xx-xxx), agaricin (gr. |—1). $. Atropin. sulph., gr. \ ; Acid, sulph. aromat., f'3ij ; Aquae rosae, q. s. ad fgj.—M. Sig.—Twenty to thirty drops at bedtime, and repeated if neces- sary. Sponging with alum and whiskey is sometimes very efficacious. Haemoptysis.—When profuse, ice may be held in the mouth and swallowed slowly. The fluid extract of ergot (gtt. xx- xxx) and morphia (gr. |) should be given hypodermically. The internal administration of gallic acid and other astrin- gents is of little value. The application of a temporary liga- ture to one or more of the members hinders the flow of blood in the veins, and may materially aid in checking the bleeding. When the hemorrhage is more or less continuous, but not profuse, the fluid extract of hamamelis (3ij_3iij) or pills of acetate of lead and opium are efficient remedies. Diarrhoea.—Best; liquid diet; subnitrate of bismuth in large doses, or pills of nitrate of silver and opium. fy Bismuth, subnit., gvj ; Salol, gr. xxiv; Morphin. sulph., gr. j.—M. Ft. in chart. No. xii. Sig.—One powder every three hours. PLEURISY. 223 Pyrexia.—The patient must rest. Continuous high fever will call for quinine, antipyrin, antifebrin, or thallin. Spong- ing with alcohol and cool water, equal parts, is a desirable method of reducing fever. Pain.—When severe, administer opium and apply to the affected side adhesive straps, hot applications, dry cups, or iodine. PLEURISY. (Pleuritis.) Definition.—Inflammation of the pleura. Varieties.—According to cause, it may be divided into primary or secondary; according to extent, into unilateral, bilateral, or local; according to time, into acute or chronic; and according to the exudation, into sero-fibrinous, fibrinous, or purulent. Etiology.—Pleurisy may be: (1) Idiopathic, arising from exposure to cold and wet. (2) Traumatic. (3) Secondary to inflammatory diseases of adjacent viscera, as pneumonia and phthisis. (4) Secondary to some general morbid process, as rheumatism, Bright's disease, tuberculosis, and the infectious fevers. (5) Tuberculous. (6) Cancerous (rare). Pathology.—In the early stage the membrane is red, sticky, lustreless, and covered with a thin film of lymph ; if the process now ceases, the condition is termed dry pleurisy. If, however, the inflammation continues, au exudate is formed which may be: (1) Sero-fibrinous, (2) fibrinous, or (3) puru- lent (empyema). In the sero-fibrinous form there is little lymph, the exudate being mainly composed of straw-colored serum (a few ounces to several pints) which in favorable cases is gradually absorbed. In large effusions the adjacent organs are displaced and the lungs are compressed. In the fibrinous form serum is scant and the membrane is cov- ered with a butter-like exudate which subsequently organizes and unites more or less closely the pleural surfaces, causing adhesive pleurisy. A liquid effusion, which is circumscribed and confined to pockets formed of adhesions, is termed saccu- lated pleurisy. 224 DISEASES OF THE RESPIRATORY SYSTEM. In the purulent form the sac is more or less filled with greenish-yellow pus. Purulent pleurisy, or empyema, is com- mon in children ; it frequently follows the infectious fevers ; it is often secondary to a sero-fibrinous pleurisy ; it results from the rupture of purulent accumulations into the pleura, as by a tuberculous cavity; and finally, it may be due to traumatism, as a penetrating wound or fracture of the ribs. A purulent effusion left to itself may kill by sepsis, may become inspissated and encysted (rare), or may perforate into the bronchi, into neighboring organs, or externally. Hemorrhagic Pleurisy.—A bloody effusion is observed in tuberculous and cancerous pleurisies and in pleurisy which is associated with scurvy, grave anaemia, and other cachectic states. An effusion of any kind remaining unabsorbed constitutes a chronic pleurisy. Symptoms. Acute Pleurisy.—Chilliness ; a stabbing pain or stitch in the affected side, intensified by deep breathing and by cough; moderate fever (101°-103°); cough short, dry, and partially suppressed; the face is generally pale and anxious; and the patient usually lies on the affected side. When the effusion forms, the inflamed surfaces separate, so that the pain becomes less; but dyspnoea rapidly develops, and the respirations are of a short, jerky character. Physical Signs. First Stage. — Less expansion on the affected side on account of the pain ; occasionally a friction- fremitus on palpation, and a harsh to-and-fro friction-rub on auscultation. Stage of Effusion. Inspection.—Immobility and bulging of the intercostal spaces on the affected side. The apex-beat is displaced upwards, and to the left or right according to the pleura affected. Palpation.—Immobility and diminished vocal fremitus. Percussion.—Dulness gradually rising as the fluid increases. The upper line of dulness is not horizontal, but is curved and rises higher posteriorly. In moderate effusions the level of dulness often changes with the position of the patient. Above the effusion percussion gives a tympanitic note which has been termed Skoda's resonance. PLEURISY. 225 Auscultation.—The respiratory sounds are weak and dis- tant ; they may have a tubular or bronchial quality. The vocal resonance is usually diminished or absent, but occa- sionally bronchophony, or its modification aegophony (a bleating sound), is heard over moderate effusions. Mensuration.—The affected side is sometimes an inch or more larger than the sound one. After absorption of the effusion the friction-sound returns. Diagnosis. Pneumonia.—The severe chill, rusty expec- toration, high fever, marked dyspnoea, the fine crepitant rales which are heard only on inspiration, dulness not changing with the patient's posture, increased vocal fremitus, increased vocal resonance, loud bronchial breathing, and the absence of bulg- ing and of a displaced apex-beat, will serve to distinguish it from pleurisy. Pleurodynia, or Rheumatism of the Intercostal Muscles.-—No fever, much diffuse tenderness, no friction-sounds, and no effusion. Purulent pleurisy is recognized by hectic symptoms—high and irregular fever, sweats, chills, and anaemia; by the results of aspiration ; and sometimes by " pitting" from oedema of the surface. Fibrinous Pleurisy.—Pain is severe and continuous, the dulness is immobile, aspiration gives negative results, and later there is much retraction of the affected side. Tuberculous Pleurisy.—Tuberculosis is the most common cause of pleurisy which is apparently primary. It may be primary or secondary to pulmonary phthisis. It usually pre- sents the same symptoms as ordinary sero-fibrinous pleurisy, but it often develops insidiously, is frequently bilateral, and the effusion is apt to be bloody. These facts, together with the history, will usually indicate the diagnosis. Diaphragmatic pleurisy, or inflammation of the diaphrag- matic pleura, may present the following symptoms : Intense pain under the margin of the ribs, with tenderness on pressure; thoracic breathing; tenderness over the phrenic nerve, which is accessible between the two roots of the sterno-cleido-mastoid at the base of the neck; hiccough; and extreme dyspnoea. The physical signs are not marked. 15 226 DISEASES OF THE RESPIRATORY SYSTEM. Prognosis.—This depends largely on the character and the amount of effusion. In primary sero-fibrinous pleurisy, the prognosis is usually good, but that pleurisies, which are apparently primary, are often tuberculous, should always be borne in mind. In purulent pleurisy, the prognosis is grave, though recovery frequently occurs. In the fibrinous form, the prognosis is good, but if there has been much exudate, subsequent retraction and more or less impairment of the affected side are sure to follow. Treatment.—Absolute rest. Light diet. If the temper- ature is high and the pulse rapid, aconite may be administered in small doses. Quinine (gr. v thrice daily) will exert a favor- able influence. Pain may be so severe as to require morphia hypodermically. Local Applications.—When the pain is severe, leeches or wet-cups, followed by strapping of the chest, will give great relief. 'In other cases, mustard plasters, hot fomentations, or iodine may be applied. Serous Effusion.—Apply, frequently, small blisters. Iodide of potassium (gr. v thrice daily) may be employed for its ab- sorbent effect. Encourage diuresis with digitalis, caffeine, or acetate of potassium:— Ifc. Potass, acetat., ^ss ; Jnfus. digitalis, f^iij.—M. Sig.—Two teaspoonfuls every three or four hours. Encourage catharsis with compound jalap powder (gr. xx- xxx) or Epsom salts. I£ Magnesii sulphat., §iv-gvj. (Hay.) Div. in chart. No. viii. Sig.—One powder in two tablespoonfuls of water before food, and no fluids for some time afterwards. The effusion will require aspiration under the following conditions: (1) When it excites much dyspnoea; (2) when it is very large, beyond the third or fourth rib ; (3) when it is purulent; (4) when it remains unabsorbed after three or four weeks of careful treatment; (5) when it is bilateral, and the total amount is sufficient to fill one cavity. HYDROTHORAX—PNEUMOTHORAX. 227 The Operation.—Anaesthetize a point in the seventh inter- space near the posterior axillary line and introduce the needle with a quick stroke along the upper border of the rib. The effusion should be drawn off slowly, and one or two pints re- moved according to the amount of the exudate. Coughing during the operation is an indication for the with- drawal of the needle. Empyema.—Make an incision in the fifth or sixth inter- space, outside of the mammary line, evacuate the pus and insert a drainage-tube. In some cases the excision of one or two ribs facilitates retraction and the obliteration of the pleural sac, which is essential to a cure. HYDROTHORAX. Definition.—Thoracic dropsy. Etiology.—It is always secondary, and may result from one of the causes of general dropsy, namely : Bright's disease, heart disease, emphysema or anaemia, or from the pressure of a tumor or aneurism upon the thoracic veins. Symptoms.—Dyspnoea, cyanosis, and the physical signs of a pleural effusion. Diagnosis.—The history of the primary disease, the fact that the effusion is bilateral, the absence of pain, and the pres- ence of a fluid which is only slightly albuminous, and which shows little or no tendency to spontaneous coagulation, will serve to distinguish it from pleurisy. Treatment.—Remedies should be directed to the original disease. When there is much dyspnoea, aspirate. PNEUMOTHORAX. Definition.—Air in the pleural sac. Etiology.—It may result from : (1) The rupture of the lung in health from a violent strain, or rupture in tuberculosis, abscess, emphysema, or gangrene. (2) Traumatism, as a pen- etrating wound or a fracture of the ribs. (3) The rupture of an empyema into the lung. 228 DISEASES OF THE RESPIRATORY SYSTEM. Pathology.—The adjacent viscera are displaced, and the lung is compressed. Even when air alone has escaped into the pleural sac, an effusion soon develops, so that in all cases the condition becomes a pneumo-hydrothorax or -pyothorax. Symptoms.—The onset is marked by a sharp pain, extreme dyspnoea, cyanosis, and symptoms of incipient collapse, namely, a fall of temperature, a weak rapid pulse, cold extremities, and pinched features. Physical Signs. Inspection.—Immobility, and bulging of the intercostal spaces. The apex-beat is usually displaced. Palpation.—Diminished vocal fremitus. Percussion.—A tympanitic note, varying in pitch with the intrathoracic tension. Effusion sinks to the base and yields dulness, the outline of which changes with the position of the patient. Auscultation.—The respiratory murmur and vocal resonance are usually absent, but when the opening in the lung remains patulous, amphoric breathing may be detected. When a silver coin is placed on the affected side and is struck with another, the auscultator detects a clear metallic sound (bell-tympany). When fluid is present, shaking the patient excites a splashing sound (Hippocratic succussion). Diagnosis. ^1 large Phthisical Cavity.—This is usually located near the apex instead of the base; the surface is sunken, not prominent; the heart is not displaced ; succus- sion-splash and bell-tympany are usually absent. Dilated Stomach.—This may give a tympanitic note over the left pulmonary base, and may simulate a pneumothorax ; but the tympanitic note is continued down into the abdomen, and the swallowing of liquid is distinctly audible over the base of the chest. Prognosis.—It is usually unfavorable, and often termi- nates fatally in a few hours or days. Recovery is possible, especially in traumatic cases. It often excites a pleural effu- sion and runs a chronic course. Treatment.—At the onset administer stimulants, and apply straps to the chest. The pain and distress must be relieved by morphia. hemothorax. 229 When effusion forms it should be treated, according to its character, as a serous or a purulent pleurisy. HEMOTHORAX. (Heematothorax.) Definition.—The effusion of blood into the pleural sac. Etiology.—Traumatism, rupture of an aneurism, or the erosion of bloodvessels by phthisical, cavities or caries of the ribs. Symptoms.—Same as hydrothorax. Treatment.—When there is great dyspnoea the blood should be removed by aspiration or incision. ACUTE INFECTIOUS DISEASES. FEVER. Fever is an abnormal condition characterized by elevated temperature, quickened respiration and circulation, faulty se- cretions, and increased tissue-waste ; and dependent upon a perversion of the physiological processes whereby the gene- ration and loss of heat are so balanced as to maintain a uni- form normal temperature. The Detection of Fever.—There is only one sure way of detecting fever, and that is by means of the clinical ther- mometer. The instrument may be placed in the axilla, mouth, rectum, or vagina. When the axilla is selected the following precautions must be observed : Wipe off the perspiration and dry the skin ; in- sert the bulb of the instrument deep in the armpit, and see that the arm is kept close to the side. The thermometer should be kept in position until the mercury maintains the same level for two minutes ; this will usually require in all about six or seven minutes. When the mouth is selected the bulb should be placed under the tongue and the lips kept closed. Hot and cold drinks recently taken mar the results. For obvious reasons the mouth should not be used in delirious patients. The rectum may be selected in children. The rectal tem- perature is about a degree higher than that of the axilla. Fehrile Stages.—The course of all fevers is marked by three stages: (1) Invasion ; (2) fastigium, or stadium ; (3) defer- vescence, or decline. Invasion.—During this period the temperature gradually rises until it reaches its maximum. (230) FEVER. 231 Fastigium.—In this period, though there may be marked variations, the temperature shows a tendency to touch again and again its highest point. Defervescence.—In this period the temperature gradually falls until it reaches the norm. , Terminations of Fever. —Fever terminates by lysis or "Tysis.—The temperature falls slowly by slight gradations until it reaches the norm. CVms.—The temperature falls suddenly, often four or five degrees in twelve or twenty-four hours. The Degree of Pyrexia.—The following is Wunderhch s classification of febrile temperatures :— 1. Subfebrile, temperature 99.5°-100.4°. 2. Slightly febrile, temperature 100.4°-101.3 . 3. Moderately febrile, temperature 101.3°-103.1 . 4. Decidedly febrile, temperature 103.1 °-104°. 5. Highly febrile, temperature above 103.1° in the morning and above 104.9° in the evening. 6. Hyperpyretic, temperature above 106°. Fehrile Remissions.—All fevers show a diurnal variation. The maximum is usually reached at about 6 P.M. and the minimum at about 6 A.M. Sometimes these extremes are re- versed and the maximum is in the morning and the minimum in the evening. The daily difference amounts to about 1 . Types Of Fever.-According to the degree of the diurnal variation three types are recognized :— # 1 Continued Fever.—The diurnal variation is slight, 1 -1.5 . Typhus fever, pneumonia, and scarlet fever are examples ot continued fevers. . . , , , 2 Remittent Fever.—The diurnal variation is marked but the minimum temperature is still above the norm Typhoid fever, remittent fever, and hectic fever are examples ot this ^'.Intermittent Fever. -The diurnal variation is marked and the minimum is normal or subnormal. The following fevers intermit:— 232 ACUTE INFECTIOUS DISEASES. 1. Intermittent fever (malaria). 2. Relapsing fever. 3. Hectic fever (often intermits, though generally remits). 4. Charcot's intermittent (the peculiar fever associated with the impaction of gall-stones). Causes of Fever. — (1) Local inflammations excited by external causes, or the products of faulty metabolism (gout, rheumatism). (2) The presence of microorganisms or ptomaines in the body, as in typhoid fever, pyaemia, scarlet fever, etc. (3) Paralysis of the heat-centre, as in thermic fever. Symptoms of Fever.—Rise of temperature; rapid pulse; rapid respirations; coated tongue; anorexia; constipation. The urine is scanty, high-colored, throws down a heavy sedi- ment, and may contain a trace of albumin. The gastric juice is deficient in acid. If the fever is long-continued, the body wastes. The Pulse-temperature ratio:— A temperature of 98.4° corresponds to a pulse of 70 " " 100° " " ' " 80- 90 " 102° " " " 100-110 " " 104° " " " 120-130 Effects of Fever on the Tissues.—High and long-continued fever produces fatty and parenchymatous degeneration of the tissues. Treatment of Fever.—Absolute rest; a cool, well-ventilated room ; liquid or semi-liquid diet. Slight fever will require no special remedies, but the patient may be made more comfort- able by sponging with cool water, or water and alcohol; and by the use of such drugs as sweet spirits of nitre, acetate of ammonium, or neutral mixture. High fever is best controlled by the external application of cold; this method includes sponging with cold water, the cold pack, and the cold bath. The Cold Pack.—A rubber sheet is slipped under the patient, and the body is enveloped in a sheet wrung out in cold water, FEVER. 233 which is allowed to remain until the temperature falls one or two degrees. The Cold Bath.—There are two methods of administering the cold bath. The first is to place the patient at once into water at 70°; the other is to place him into water at 90° or 80°, and then gradually cool it down to 75° or 70°. While in the water he should be subjected to gentle friction or massage. He should remain in the bath for fifteen or twenty minutes, after which he should be placed in a dry sheet and covered with a light blanket. When the body is dry the damp sheet should be removed. A stimulant is sometimes required during or after the bath. Drugs may be employed to lower temperature, but the bath is preferable when it is feasible. Quinine, antipyrin, phe- nacetin, and antifebrin are the antipyretics most commonly employed. Period of Incubation.—The period elapsing between the en- trance of the poison and the development of symptoms. It varies considerably in the same disease, being more or less influenced by the susceptibility of the patient and the virulence of the coutagion. The average period of incubation in the in- fectious fevers is as follows :— Typhoid fever: two to three weeks. Typhus fever: a few hours to two weeks. Measles: two weeks. Rotheln or rubella: ten to twelve days. Scarlatina: a few hours to a week. Smallpox: one to two weeks. Erysipelas: three to seven days. Diphtheria: two to ten days. Varicella: ten to fifteen days. Tetanus: a few days to two weeks. Mumps: two to three weeks. Yellow fever: from a few hours to a week. The date at which rashes appear in the various diseases:— Typhoid fever: seventh to the ninth day. Typhus fever: fourth or fifth day. 234 ACUTE INFECTIOUS DISEASES. Smallpox: third or fourth day. Measles: third or fourth day. Scarlatina: first or second day. Rotheln or rubella: first or second day. Varicella: first day. Protection from Future Attacks.—Few diseases give abso- lute immunity from future attacks, but the following are fairly protective:— Typhoid fever: relapses are common, and second attacks some- times occur. Typhus fever : second attacks very rare. Measles: second attacks uncommon ; what is supposed to be a second attack is usually rotheln. Rotheln: second attacks uncommon. Scarlatina: second attacks rare. Smallpox: second attacks occasionally occur. Mumps: second attacks rare. Yellow fever: second attacks rare. The following do not confer immunity :— Erysipelas. Malaria. Relapsing fever. Influenza. Diphtheria. Croupous pneumonia. Periodic Remission or Intermissions in the Fever.—Such remissions or intermissions occur in the following fevers :— Malarial fever: every day, every third day, or every fourth day, according to the type. Relapsing fever : intermissions occur at intervals of five or six days, and last five or six days. Smallpox: remission occurs on the third day. Measles: a distinct remission often occurs on the second or third day. Yellow fever: a marked remission on the second or third day. Dengue: a marked remission on the third or fourth day, which lasts two or three days, and is repeated about the ninth or tenth day. SUBNORMAL TEMPERATURE. 235 The Infectious Fevers which are usually Associated with Jaundice:— Yellow fever. Relapsing fever. Acute yellow atrophy of the liver. Bilious remittent fever. Termination hy Crisis.—The following infectious fevers are apt to end by crisis :— Typhus fever. Measles. Pneumonia. Relapsing fever. Influenza. Erysipelas. SUBNORMAL TEMPERATURE. Temperatures below 97.5° may be considered subnormal. They are observed in the following conditions :—• 1. During convalescence from certain febrile diseases; after pneumonia and typhoid fever the temperature may remain subnormal for several days. 2. In collapse. This may result from shock ; from hemor- rhage ; from the action of some toxic agent; from simple heart- failure in the course of disease; or from the rupture of a viscus, as the bowel in typhoid, the lung in phthisis, or the stomach m perforating ulcer. 3. In cholera. In this disease the temperature may be very low (90°-85°) for several days. 4. In certain chronic diseases, especially diabetes, cancer, chronic cardiac, cerebral, and spinal diseases. 236 ACUTE INFECTIOUS DISEASES. SIMPLE CONTINUED FEVER. (Pebricula, Ephemeral Fever.) Definition.—An acute febrile disease, of short duration, and not excited by a special poison. - Etiology.—It is generally met with in young and sensi- tive individuals. Exposure to the sun, prolonged physical or emotional excitement, and errors in diet seem to excite it. Symptoms.—The disease usually begins abruptly with chilliness, headache, malaise, and fever which soon attains a maximum of 102° or 103°. The face is flushed ; the pulse is full and rapid ; the urine is scanty and high colored; the tongue is coated ; the appetite is lost; and the bowels are con- stipated. There is no characteristic eruption, but herpes is frequently observed on the lips. The disease lasts from a few days to two weeks, and may end by crisis or lysis. Diagnosis.—Care must be taken to exclude local inflam- mations, such as gastritis, tonsillitis, and pneumonia. Typhoid Fever.—At first the diagnosis may be impossible, but the absence of diarrhoea, tympanites, abdominal tender- ness, splenic enlargement, and eruption will soon make the diagnosis apparent. Remittent Fever,—The history, locality, splenic enlargement, and haematozoa in the blood will serve to distinguish this dis- ease from simple continued fever. Prognosis.—Favorable. Treatment.—Absolute rest in bed. A liquid diet. Re- peated small doses of calomel may be employed to relieve the constipation. The fever may be controlled by sponging with water and alcohol or by the use of some mild refrigerant mixture like the following:— Tinct. aconit. rad., gtt. iij ; Spt. sether. nitrosi, fgss ; Liquor, amnion, acetat., q. s. ad f^iij.—M. Sig.—A dessertspoonful every two hours to a child of four years. TYPHOID FEVER. 237 TYPHOID FEVER. (Enteric Fever, Typhus Abdominalis.) Definition.—An acute infectious disease, excited by a special bacillus, characterized anatomically by definite lesions in Peyer's patches, mesenteric glands, and spleen; and mani- fested clinically by fever, headache, stupor, abdominal disten- tion and tenderness, diarrhoea, enlargement of the spleen, and a rose-colored abdominal rash. Etiology.—Predisposing causes : Autumn season, early adult life, and a personal susceptibility. Exciting cause : The bacillus of Eberth. The intestinal discharges are the source of the contagion, and drinking-water contaminated by them becomes the chief medium of trans- mission. Pathology.—The characteristic lesions are found in the abdominal lymphatics, namely, in Peyer's patches, solitary glands, and mesenteric glands/ The changes in Peyer's glands are best studied in the lower part of the ileum, which should be opened on the side of the mesenteric attachment. In the first few days the glands are swollen and hyperaemic ; later there is a marked cell-proliferation, the bloodvessels are compressed, and the glands become pale and prominent (me- dullary infiltration). If the disease advances, necrosis sets in about the second week; the glands become yellow and soft and discharge their contents, leaving behind irregular oval ulcers with swollen and undermined edges, and with smooth bases formed by the submucous coat, muscular coat, or perito- neum. In the fourth week cicatrization begins, and the gland is ultimately replaced by a smooth depressed scar. In addition to these glandular lesions, the mucous membrane of both large and small intestines shows catarrhal changes. In mild cases the stage of ulceration may not be reached, the proliferated cells being removed by fatty degeneration and absorption without rupture of the gland. The solitary and mesenteric glands pass through similar changes, but the latter rarely rupture. Other lesions are found which are not charac- teristic. The spleen is soft and swollen, and occasionally rup- 238 ACUTE INFECTIOUS DISEASES. tures. The liver, kidneys, heart, and muscles reveal paren- chymatous degeneration. The respiratory tract is commonly the seat of catarrhal inflammation. Period of Incubation.—Two to three weeks. Fig. 17. Symptoms. Prodromal Symptoms.—Gradual weakness, headache, vague pains, nose-bleed, and often slight diarrhoea. The Attack. Fever.—The temperature rises gradually, reach- ing a maximum (104°—105°) in from one to two weeks; it remains at this elevation for another period of from one to two weeks, when a gradual defervescence begins and occupies a third period lasting from one to two weeks. Throughout its course the fever is characterized by marked daily remis- sions, the evening temperature being from one to three degrees higher than the morning. In some cases, especially in the young, the temperature rises quite abruptly. Slight diurnal remissions indicate a protracted case. As defervescence advances, the temperature becomes more irregular; the remissions are more decided, and not in- frequently the higher temperature is recorded in the morning. An abrupt fall of several degrees should suggest intestinal hemorrhage or perforation. Respiratory Symptoms.—Hurried respirations, slight cough, and bronchial rales. Circulatory System.—The pulse becomes rapid, weak, and dicrotic. The rapidity is often less than such temperatures generally produce. The heart-sounds become feeble. The first is especially weak and resembles the second. typhoid fever. 239 The Face.—The expression is dull and heavy, the cheeks are somewhat flushed, the conjunctivae are clear, and the pupils dilated. The tongue is tremulous; at first it is red at the tip and edges, and covered posteriorly with a whitish fur. In severe cases the tongue becomes dry, brown, and fissured, and sordes collect on the teeth. The Stomach.—Gastric symptoms are not common, but ob- stinate vomiting sometimes develops and becomes a serious complication. Intestinal Symptoms.—The belly is distended with gas. Ten- derness is frequently noted on palpation; it may be general, or confiued to the right iliac fossa. Gurgling may also be detected in the latter region, but it has little significance. Diarrhoea is generally present, though it is not a constant symptom. The discharges vary in number from three to six or more a day; they are thin, offensive, and of a yellowish color (likened to pea-soup); on standing, a turbid liquid rises to the top and a granular sediment falls to the bottom. The Eruption.—This appears from the seventh to the ninth day, and is most abundant on the abdomen, though it is not infrequently observed on the chest and back. It is composed of small, slightly elevated, rose-colored spots which disappear on pressure. It comes out in successive crops over several days. It may be absent particularly in the old and very young. Rarely, in malignant cases, is the eruption petechial. Sudamina are also noted, and result from free perspiration. Splenic enlargement is rarely absent. The organ may rupture. Nervous Symptoms.—Headache, slight deafness, stupor, muttering delirium, twitching of the tendons (subsultus ten- dinum), picking at the bedclothes or imaginary objects (car- phologia), and coma vigil (the eyes are open, but the patient is unconscious). The urine is febrile and often slightly albuminous. Reten- tion is common. Convalescence is marked by anaemia, falling of the hair, de- squamation of the cuticle, and often mental enfeeblement. Varieties. Mild Typhoid.—There is moderate fever with marked remissions; the diarrhoea is slight; nervous symp- 240 ACUTE INFECTIOUS DISEASES. toms are often absent; the rash is usually present, and often abundant. Abortive Typhoid.—There is an abrupt onset with severe symptoms, but convalescence follows in a few days. Walking Typhoid.—The symptoms are mild, and often dis- regarded by the patient, who refuses to go to bed; but grave symptoms may develop suddenly, and death from perforation is not uncommon. Typhoid in Children.—The rash is often absent; the fever rises abruptly ; cerebral symptoms are marked. Complications.—Any symptom aggravated constitutes a complication; thus high fever, excessive diarrhoea, and tym- panites become complications. Hemorrhage.—This usually occurs during the third week, and is indicated by a sudden fall of temperature, followed by dark red or tarry stools. Peritonitis.—This may result from perforation, or from ex- tension by contiguity. The former is the most common, and is recognized by a sudden pain, a fall of temperture, disten- tion of the belly, and symptoms of peritonitis. Pneumonia and hypostatic congestion of the lungs are com- mon complications. Among less frequent complications or sequelae may be men- tioned : Nephritis, pyelitis, tuberculosis, temporary insanity, parotitis, and phlegmasia dolens. Relapse and Recrudescence.—Relapses are quite com- mon ; they repeat the symptoms of the original attack, but they are generally milder and of shorter duration, and seldom prove fatal. Recrudescence.—This is a sudden temporary elevation of temperature occurring during convalescence, and is not asso- ciated with a return of the other symptoms. It is usually due to constipation, excitement, or irritating food. Diagnosis.—Acute miliary tuberculosis often closely resem- bles typhoid fever. In tuberculosis the temperature is gen- erally more irregular; the abdominal symptoms are less marked; pulmonary symptoms, especially dyspnoea, are more marked; the rash is absent; tubercles may be detected on the TYPHOID FEVER. 241 retina; and symptoms of basilar meningitis may be present, such as irregular pupils, ptosis, and strabismus. Ulcerative Endocarditis.—The diagnosis may be impossible, but the following features would suggest endocarditis: The history of a primary disease which might induce ulcerative endocarditis; irregular fever; intercurrent rigors; praecordial pain and endocardial murmurs; and the absence of a rose- colored rash and of marked abdominal symptoms. Enteritis.—The absence of high fever, of eruption, of splenic enlargement, of epistaxis, of bronchial catarrh will serve to distinguish enteritis from typhoid fever. Meningitis.—The abrupt onset, the early development of cerebral symptoms, the irregular fever, and the absence of a rash and of abdominal symptoms will indicate meningitis. Prognosis.—The prognosis should always be guarded. No case is too mild to prove fatal, and no case is too severe to recover. The mortality varies in different epidemics. In private practice the average is probably between five and ten per cent., and in hospital practice it is somewhat more. Continued high fever with slight diurnal remissions, exces- sive diarrhoea, severe cerebral symptoms, and repeated hemor- rhages are unfavorable features. Treatment.—Absolute rest in bed and the enforced use of the bed-pan. The stools should be rendered innocuous. This may be done by dissolving a pound of chloride of lime in four gallons of water, and adding a quart of the solution to each discharge, and allowing it to remain in the vessel at least an hour before disposing of it. Soiled bedclothes should be thoroughly boiled. The diet must be liquid, and preferably milk. From two to four pints should be given in the twenty-four hours, and should be so divided that the patient shall receive a small amount every two hours, day and night. When it causes eructations or flatulence, or is discharged undigested, it must be mixed with lime-water, or be predigested. Koumiss is often acceptable. Meat-broths may be given to vary the monotony of a milk diet. Cool water or ice will be required to allay thirst, and even if the latter is absent, it is well to give one or the other at regular intervals. When the first 16 242 ACUTE infectious diseases. sound of the heart weakens and the pulse becomes soft, stimu- lants should be administered. It is desirable to give the alcohol with the milk so as to stimulate the stomach to digest the latter, and at the same time to diminish the number of administrations of food and medicine. From four to eight ounces of brandy or whiskey may be required in the twenty- four hours, the amount being determined by the general effect. When additional stimulation is required strychnine is a valu- able adjunct. When the tongue becomes dry and brown, the belly much distended, and low nervous symptoms develop, turpentine will be found an invaluable stimulant. Five to ten minims may be given in capsule or emulsion every two or four hours. Antiseptic remedies have been strongly advocated, but their efficiency has not been clearly demonstrated. Thymol, naphthol, carbolic acid, chlorine-water, iodine, and calomel are the anti- septics which have been recommended. The use of the cold bath or the cold pack will be found an excellent method of controlling fever and of preventing the development of severe nervous symptoms. It is especially val- uable as a stimulant to the nerve-centres, and may be employed whenever the temperature exceeds 102^°. Hemorrhage and perforation contraindicate its use. (See page 233.) Fever.—When circumstances prevent the use of the cold bath, sponging with cool water and the administration of such antipyretics as quinine (gr. xx-xxx) or antipyrin (gr. v—x) may be substituted. Diarrhoea.—When diarrhoea exceeds more than three or four stools a day, it is well to check it by an opium sup- pository, or by bismuth or nitrate of silver by the mouth. $. Pulv. opii, gr. iij ; 01. theobrom., q. s.—M. Ft. in suppos. No. vi. Sig.—One, two or three times daily. Or— ty. Morph. sulph., gr. j ; Creosot., gtt. vj ; Bismuth, subnit., ^iij.—M. Ft. in chart. No. xii. Sig.—One every two or three hours. typhus fever. 243 Or— 1$. Argenti nit., gr. v ; Ext. opii, gr. iv. —M. Ft. in pil. No. xx. ■ Sig.—One every three hours. Constipation.—This may be relieved by an enema of soap and water, or by broken doses of calomel. Tympanites.—Turpentine stupes. Turpentine or thymol in- ternally. In grave cases, rectal intubation. Hemorrhage.—An ice-bag to the right iliac fossa. Morphia (gr. |)with ergotine (gr. v-x) hypodermically. Turpentine or gallic acid may be administered by the mouth. Perforative Peritonitis.—This is almost invariably fatal. Opium should be administered freely. Laparotomy is rarely warrantable Heart-failure.—When alcohol is being pushed aud the symptoms of heart-weakness still persist, such remedies as aromatic spirits of ammonia, ether, strychnine, digitalis, or cocaine may prove useful. Grave Nervous Symptoms.—Delirium, subsultus, insomnia, etc. may be due to fever or lack of stimulation ; cold bathing is indicated in the former, and the free use of alcohol-in the latter. Nerve sedatives, like the bromide of potassium, musk, hyoscine, sulphonal, and camphor, are sometimes required. TYPHUS FEVER. (Ship Fever, Jail Fever.) Definition.—An acute contagious disease unassociated with any characteristic lesions of the solids, and manifested by great prostration, a petechial rash, marked nervous symptoms, and high fever which defervesces by crisis in from ten to fourteen days. Etiology.—It is excited by an unknown poison which is capable of being carried in clothes (fomites). It is rare in America, but not uncommon in England and Ireland. Bad food, impure water, overcrowding, and foul air are predis- posing factors. 244 acute infectious diseases. Pathology.—There are no characteristic lesions of the solids. As in other fevers, the liver and spleen are swollen, and the tissues reveal fatty and parenchymatous degeneration. The blood shows a peculiar change : it is dark, fluid, and stains the lining of the heart and great bloodvessels bright red. Period of Incubation.—A few hours to two weeks. Fig. 18. Temperature chart of typhus. Symptoms.—Typhus fever begins abruptly with pain in the head, back, and limbs; extreme prostration; and fever which reaches its maximum (104°-105°) in two or three days. The temperature remains high for about ten days, when it falls by crisis. The pulse is rapid, weak, and often dicrotic. The tongue is tremulous, and usually covered with a whitish fur; but in bad cases it becomes black and rolled up like a ball in the back of the mouth. The face is dusky ; the conjunctivae are injected; and the pupils are contracted. Nervous Symptoms.—These are prominent, and consist of headache, stupor, delirium, subsultus tendinum, carphologia, and coma vigil. The Eruption.—About the fourth or fifth day rose-colored spots appear over the body ; these rapidly become hemorrhagic, or petechial, and fail to disappear on pressure. There is a distinct relation between the amount of eruption and the severity of the attack. In addition to this " mulberry rash " there is often a diffuse, dark-red subcuticular mottling. RELAPSING FEVER. 245 Gastro-intestinal Symptoms.—The stomach is retentive, and the bowels are constipated. Urine.—The urine is scanty, high-colored, and often albu- minous. Complications.—Hyperpyrexia, catarrhal pneumonia, hypostatic congestion of the lungs, nephritis, and parotid abscess. Diagnosis. Cerebrospinal Meningitis. — In this affection the pain in the back is greater. The fever is very irregular; there is greater tendency to opisthotonos and facial palsies; and the eruption, though it may resemble that of typhus, is incon- stant and without a special time for appearing. Typhoid Fever.—The resemblance is in the nervous phe- nomena only. In typhoid the fever rises and falls very gradually; the eruption appears later, remains rose-red, and does not become petechial; the face is not dusky, the eyes are not injected ; and there are marked abdominal symptoms. Prognosis.—The mortality is much greater than in typhoid fever. Advanced years and alcoholism render the prognosis decidedly unfavorable. Treatment.—Isolation ; absolute rest; liquid diet. There is no specific treatment. Alcohol is nearly always required. Quinine and mineral acids are useful tonics. Pyrexia, nervous phenomena, and heart-failure should be treated as in typhoid fever. RELAPSING FEVER. (Spirillum Fever, Famine Fever.) Definition.—An acute contagious disease excited by the spirochaete of Obermaier, and characterized by paroxysms of high fever which last five or six days and are followed by in- termissions of a similar duration. Etiology.—The exciting cause is the spirochaete of Ober- maier, a spiral-shaped microbe three or four times as long as the diameter of a red blood-corpuscle. Bad water, poor food, overcrowding, and foul air predispose to epidemics. The disease is highly contagious. 246 ACUTE INFECTIOUS DISEASES. Pathology. — There are no characteristic lesions. The liver and spleen are much enlarged, and the latter is frequently the seat of infarctions. There is usually catarrhal inflamma- tion of the stomach and bile-ducts. The spirochaete is found in the blood during life, but only during the paroxysms; after death it is found in all the organs. Period of Incubation.—Five to eight days. Fig. 19. Temperature curve in relapsing fever. Symptoms.—The disease begins abruptly with a chill fol- lowed by fever, which reaches its maximum (105°-106°) in twenty-four hours, and remains high for from five to seven days, when it falls by crisis. After an intermission of five or six days it again rises rapidly and remains high for a similar period. Convalescence usually begins at the end of the second paroxysm, but it may not begin until after the third or fourth. Other noteworthy symptoms are intense pains in the head, back, and limbs; the spirochaete in the blood ; and frequently jaundice. Complications.—Hyperpyrexia, nephritis, pneumonia, and ophthalmia. Diagnosis. Rheumatic Fever.—The history, irregular fever, acid sweats, and the absence of spirilli and of jaundice will serve to distinguish rheumatism from relapsing fever. Remittent Fever.—In this disease the fever remits, but does not intermit; the paroxysms are more frequent; and instead of spirilli, haematozoa are found in the blood. CEREBRO-SPINAL FEVER. 247 Yellow Fever.—The single remission on the second or third day, the bloody vomit, and the absence of spirilli and of splenic enlargement will indicate yellow fever. Prognosis.—Favorable in uncomplicated cases. Treatment.—Isolation ; rest; liquid diet. As a general tonic, quinine is useful. For the pains, antipyrin, phenacetin, or morphia may be given internally, and rubefacients used locally. For the irritable stomach hot fomentations may be applied to the epigastrium, and small doses of calomel and soda administered internally. CEREBRO-SPINAL FEVER. (Epidemic Cerebro-Spinal Meningitis, Spotted Fever.) Definition.—A specific infectious disease characterized anatomically by inflammation of the cerebro-spinal meninges, and clinically by intense pain in the head, back, and limbs, convulsions, irregular fever, and frequently by a petechial eruption. Etiology.—The disease may be sporadic of epidemic. Overcrowding, poor food, foul air, and bad drinking-water seem to predispose to epidemics. Outbreaks are most common in the winter and spring. The young are more susceptible than the old. The disease is not contagious; the method of transmission is still unknown. The Exciting Cause.—This is unquestionably a micro-organ- ism. Certain diplococci have been repeatedly found in the exudations, but they have not been proven to be the exciting factors. Pathology.—In most cases the membranes of the brain and cord are deeply congested and opaque. Lymph and pus are found both at the base and on the convexity of the brain, especially in the fissures and along the bloodvessels. The spinal meninges present similar changes, the posterior surface of the cord being particularly involved. The liver and spleen are engorged and the muscles reveal granular degeneration. In rapidly fatal cases the lesions are very slight. 248 ACUTE INFECTIOUS DISEASES. Symptoms. Common Form.—The disease generally begins abruptly with a chill, followed by vomiting and excruciating pain in the head, back, and limbs. The muscles of the neck and back become rigid and contracted, so that the head is bent backward and the back is straightened; in severe cases the body may be arched in a state of opisthotonos. The mind is soon affected ; delirium is rarely absent, and in severe cases it is followed by stupor and coma. Involvement of the Cranial Nerves.—Pressure of the exudate upon the cranial nerves may produce the following symptoms : Nystagmus (tremor of the eyeball); strabismus; ptosis; irregu- lar, sluggish pupils ; and partial deafness or blindness. Involvement of the Spinal Nerves.—There is extreme cutaneous hyperesthesia, so that the slightest touch excites pain. The muscles of the extremities are stiff and may twitch, but are rarely palsied. The patellar reflex is usually diminished. The joints are occasionally red, swollen, and painful. Febrile Symptoms.—The temperature is irregular in its course and indefinite in its duration ; ordinarily it ranges be- tween 101p and 103°, but in some cases it is almost normal, and in others it is very high. The pulse is rapid and full; the bowels are constipated ; and the urine may contain albumin and sugar. Polyuria is an occasional symptom. The Eruption.—The eruption is neither constant nor pecu- liar. In many cases a blotchy purpuric rash appears over the entire body. Herpes facialis is also frequently observed. In other cases urticaria, or a roseolar or erythematous rash ap- pears. The duration is from a few hours to several weeks. In favorable cases, convalescence is very protracted. Fulminant Form.—There is an abrupt onset with a chill, followed by vomiting, headache, moderate fever, convulsions, a petechial or purpuric rash, and death in a few hours from collapse. Abortive Form.—The disease begins abruptly with grave symptoms, but terminates in a few days in recovery Intermittent Form.—The fever is characterized by inter- missions or marked remissions which occur daily or every other day. CEREBRO-SPINAL FEVER. 249 Diagnosis. Typhoid Fever.—The gradual onset, the regu- lar fever, the diarrhoea and tympanites, and the absence of rigidity, of intense pain in the back and limbs, of facial palsies and of herpes, will separate typhoid from cerebro-spinal fever. Typhus Fever.—The regular fever, the absence of intense pain in the back and limbs, of facial palsies, and of muscular rigidity, will distinguish typhus from cerebro-spinal fever. Acute articular rheumatism may resemble cerebro-spinal meningitis, but the early involvement of the joints, the acid sweats, and the absence of rigidity, of eruption, and of facial palsies, will distinguish it from cerebro-spinal meningitis. Tuberculous Meningitis.—In this disease the onset is less abrupt; there is less tendency to opisthotonos; herpes is rare; and petechia? are always absent. Tuberculous meningitis in the adult is always secondary to tuberculosis elsewhere. Prognosis.—The mortality varies in different epidemics from 20 to 80 per cent. The prognosis should always be guarded ; the mildest cases may prove fatal. Severe cerebral symptoms usually indicate a fatal termination. Complications and Sequels.—Defective vision from inflammation of the cornea or retina, or from atrophy of the optic nerve; defective hearing from inflammation of the auditory nerve, or from suppurative inflammation of the internal or middle ear; pneumonia ; arthritis; aphasia ; periph- eral palsies; chronic hydrocephalus; and persistent head- ache from chronic meningitis. Treatment.—A liquid or semi-liquid diet. Ice-bags may be applied to the head and along the spinal column. Pain and restlessness should be relieved by morphia, bromides, or chloral. Morphia is especially efficacious, and may be injected along the course of the most painful nerve-trunks. Dry or wet cups over the spine are sometimes useful. Iodide of potassium (gr. v-x thrice daily) may be administered internally. Dr. Pepper recommends quinine (gr. v thrice daily) with the fluid extract of ergot (3j every three or four hours). When the pulse weakens, stimulants should be given freely. High fever may be controlled by sponging with cold water, by the cold pack, or by the internal use of phenacetin or antipyrin. 250 ACUTE INFECTIOUS DISEASES. During convalescence, iodide of potassium as an absorbent, tonics, and blisters to the spine are indicated. MALARIAL FEVER. (Chills and Fever, Fever and Ague, Swamp Fever.) Definition.—A specific non-contagious disease, invariably associated with, and probably excited by, the haematozoa of Laveran, and characterized by splenic enlargement, by fever with periodic intermissions or remissions, and by a tendency to extreme anaemia. Etiology.—A warm climate and the summer season, a moist atmosphere; low, badly-drained soil; and decaying vegetable matter are the conditions which favor the develop- ment of the malarial poison. Special Predisposing Causes.—Residents in the lowlands are more liable to be infected than those who dwell on the hills; one attack seems to predispose to others; visitors to malarial districts are more susceptible than permanent residents; in the night and in the early morning the air is thoroughly im- pregnated with the miasm, and exposure at such times is very apt to be followed by infection. Exciting Cause.—The hcematozoon first described by Laveran is probably the exciting cause of malaria. Manifestations.—Malarial intoxication may manifest itself as (1) intermittent fever; (2) remittent fever; (3) perni- cious malarial fever; and (4) chronic malarial cachexia. Pathology.—The bodies found in the blood of those suffering with malarial fever belong to the protozoans. A^ari- ous forms are noted, some of which are distinct species, while others are merely phases of existence in the life of the same organism. These different species and phases have to a limited extent been associated with the different clinical manifestations of the disease. The organisms are most commonly found within the red corpuscles, and are most abundant during the paroxysms. The following are the principal forms : (1) A pigmented amoe- boid form; (2) a non-pigmeuted amoeboid form ; (3) a crescentic form ; (4) a flagellate form. Intermittent fever is generally , MALARIAL fever. 251 associated with the amoeboid forms. The crescents are found particularly in remittent fever and in chronic malarial cachexia. The flagellate form is rarely found in man. When present in the blood, they destroy the red corpuscles, liberate the pig- ment, and ultimately lead to extreme anaemia. Fig. 20. In advanced malaria the blood shows a diminished number of red blood-corpuscles and an abundance of free pigment (melanaemia). The spleen is greatly swollen and deeply pig- mented (ague-cake); the liver is moderately enlarged and pigmented. All the organs, including the brain and spinal cord, are discolored by the liberated pigment. Intermittent Fever. Definition.—A form of malarial fever, characterized by febrile paroxysms which are attended with a cold, a hot, and a sweating stage. Symptoms. Cold Stage.—Malaise; headache; great chilli- ness. The features are pinched; the lips are blue; the surface of the body is cold and covered with cutis anserina (goose- flesh), although the rectal temperature is high (104°-105°). Vomiting may occur. The chill lasts from a few minutes to an hour or two. Hot Stage.—The surface temperature gradually rises; the skin becomes hot; the face flushed ; the eyes injected ; and the pulse full and rapid. The temperature in the axilla may reach 106° or 107°. The patient complains of severe pain in the head, back, and limbs, and of intense thirst. The urine is scanty and dark-colored. This stage usually lasts from one to five hours. 252 ACUTE INFECTIOUS DISEASES. Sweating Stage.—The fever gradually subsides; the pain grows less ; free perspiration follows; and the patient falls to sleep, from which he awakes feeling fairly well. Percussion reveals enlargement of the spleen; and an ex- amination of the blood during the paroxysm shows the haema- tozoa undergoing segmentation. Varieties.—When the paroxysms occur every day, the disease is termed quotidian intermittent; every other day, tertian intermittent; every fourth day, quartan intermittent. When two paroxysms occur in a single day, the disease is termed double quotidian intermittent. Diagnosis.—The presence of hsematozoa in the blood will serve to distinguish malaria from all other intermittent types of fever. Prognosis.—Always favorable. Even when no treatment is instituted, the paroxysms gradually subside. Chronic ma- larial cachexia sometimes results from the acute disease. Remittent Fever. (Bilious Remittent Fever, Jungle Fever.) Definition.—A form of malaria in which the temperature distinctly remits, but does not intermit. Etiology.—This form occurs especially in the marshy dis- tricts of hot climates. Remissions, instead of intermissions, indicate a greater virulence of the poison, or a greater suscepti- bility on the part of the patient. Symptoms.—Malaise with moderate chilliness, followed by a continuous fever which daily remits. The maximum tem- perature ranges from 104° to 106°, and while this lasts the skin is hot, the face is flushed, the eyes are injected, the pulse is full and rapid, the urine is scanty, and the patient complains of pain in the head and limbs. Delirium is some- times noted ; vomiting often occurs ; and jaundice may develop from destruction of the red blood-corpuscles and liberation of their pigment. The spleen is enlarged, and an examination of the blood reveals haematozoa. In some cases the symptoms resemble typhoid fever, and to MALARIAL FEVER. 253 these the term typho-malarial fever has been applied. In severe cases the symptoms resemble pernicious malarial fever. Diagnosis. Typhoid Fever.—The absence of diarrhoea, of tympanites, of eruption, and of a gradual rise in temperature, and the presence of haematozoa and of marked remissions will serve to separate remittent fever from typhoid. Yellow Fever.—The splenic enlargement, the haematozoa, the multiple remissions, and the absence of bloody vomit will separate remittent from yellow fever. Prognosis.—Favorable; the average duration is from one to two weeks. Pernicious Malarial Fever. (Congestive Chills, Malignant Malaria.) Definition.—A malignant form of malaria, occurring es- pecially in the tropics, and characterized by choleraic symp- toms, by coma, or by a tendency to bleed from the various organs. Varieties.—According to its expression, the following varieties have been made : (1) Algid ; (2) comatose ; (3) hem- orrhagic. Symptoms. Algid.—The symptoms resemble the cold stage of cholera. The surface is cold; the temperature may be subnormal; there is great prostration; the features are pinched ; the pulse is feeble. Vomiting and purging may follow ; death often results in collapse. Comatose.—There is delirium, rapidly followed by stupor and coma; the latter may or may not be associated with con- vulsions. The skin is hot; the face is flushed; the eyes in- jected ; and the temperature high. The symptoms gradually disappear, but unless the patient is speedily cinchonized they return and commonly prove fatal. Hemorrhagic.—In this form hemorrhages occur from the mucous membranes, especially from the kidneys, stomach, and bowels, and the patient is frequently jaundiced. Diagnosis.—The algid form may resemble cholera, but the history, the absence of an epidemic, and the presence of the hamiatozoa in the blood will render the diagnosis apparent. 254 ACUTE INFECTIOUS DISEASES. Yellow Fever.—The hemorrhagic form may resemble yellow fever, but the splenic enlargement, the late appearance of jaun- dice, the presence of haematozoa in the blood, and the absence of an epidemic will serve to distinguish the two diseases. Prognosis.—Extremely guarded ; the first paroxysm rarely kills, but unless the patient is thoroughly cinchonized a second one may prove fatal. Chronic Malarial Cachexia. Definition.—A chronic manifestation of malaria, charac- terized by anaemia, by a sallow appearance of the skin, and by splenic enlargement. Etiology.-—It may result from repeated attacks of the acute disease, or it may develop as a primary condition from slow infection. Symptoms.—The patient is thin and pale; the complexion is of a dirty yellow or muddy hue; fever is often absent; if present, it is slight and irregular ; the spleen is considerably enlarged. There is great weakness from the attending anaemia. Headache and neuralgia are common symptoms. Hematuria is sometimes observed. Diagnosis. Leucaemia.—The history, the absence of leuco- cytosis and of lymphatic enlargements, and the presence of haematozoa in the blood will indicate malaria. Prognosis.—Guarded. When the spleen is very large and there is extreme anaemia, recovery rarely follows. Other Manifestations of Malaria. One of the following conditions may be the chief manifes- tation of malarial intoxication : Neuralgia, headache, hema- turia, purpura, orchitis, or paraplegia. Malarial infection seems to predispose to certain cases of dysentery, of pneumonia, and of amyloid degeneration of the viscera. Treatment of Malarial Diseases. Prophylaxis.— Patients living in malarial districts should avoid the night and early morning air, and should take quinine (gr. iij-v a day) during the season in which the disease is prevalent. MALARIAL FEVER. 255 Cold Stage of Intermittent.—Cover the patient with blankets, and apply hot cans or hot bottles to the feet. When the chill is severe and prolonged, morphia is very useful; it may be given hypodermically. Hoffmann's anodyne may be employed as a substitute. Inhalations of nitrite of amyl are followed by dilatation of the superficial bloodvessels, and in this way serve to shorten the chill. Hot Stage of Intermittent.—Sponge the body with cool water, and if the symptoms are severe phenacetin may be given to lower the temperature and to lessen the pain. The Interval.—It is well to begin the treatment by the administration of a laxative, and calomel may be selected. This should be followed by quinine (gr. xv-xx) in divided doses, so that the last dose is taken two hours before the time of the expected paroxysm. In children, quinine may be given in lozenges made with chocolate and sugar. In adults, it is best administered in fresh pills or in capsules. These doses of quinine should be continued until the paroxysms disappear, when the amount may be gradually diminished. The treat- ment should be continued for several weeks. During conva- lescence it is advisable to give arsenic in the form of Fowler's solution with the quinine. The following pill is also useful in the convalescence of malaria :— I£ Acid, arsenosi, gr. ss; Quinin. sulph., 3j ; Ferri pyrophos., gr. xxx ; Pulv. capsici, gr. xv.—M. Ft. in pil. No. xxx. Sig.—One thrice daily. Remittent Fever.—Absolute rest. A light diet. Quinine (gr. xx-xxx) should be given in divided doses in the course of a day. A laxative dose of calomel is a valuable adjunct to the antiperiodic treatment. When the stomach is irritable calomel and soda may be given by the mouth, and the quinine by the rectum or hypodermically. In some cases Warburg's tincture is useful; half an ounce undiluted may be given, and repeated in two or three hours. After its administration the patient should he thoroughly covered with blankets so as to favor free diaphoresis. 256 ACUTE INFECTIOUS DISEASES. Pernicious Malarial Fever.—From fifty to a hundred grains of quinine must be given before the second paroxysm occurs. It is advisable to begin at once without waiting for the inter- mission ; and twenty to thirty grains may be given hypoder- mically every two or three hours. I£ Quininse sulph., gr. xl; Sat. sol. acid, tartar., Tflxlviij ; Aquse destil., q. s. ad f^ij.—M. Sig.—Tfl.xxx=gr. x. When the pulse weakens, stimulants, like whiskey, ammonia, and strychnia, should be employed. High temperature should be controlled by the external application of cold. In the algid form, heat should be applied externally, and opium given by the mouth or hypodermically. In the hemor- rhagic form, opium is also useful, and it may be associated with haemostatics like turpentine, erigeron, or hamamelis. Chronic Malarial Cachexia.—Iron, quinine, and arsenic are the remedies indicated. SCARLET FEVER. (Scarlatina.) Definition.—An acute contagious disease, characterized by high fever, a rapid pulse, a punctiform scarlet rash, sore throat, and an unusual tendency to nephritis. Etiology.—The specific poison of scarlet fever has not been isolated. The contagium is usually carried through clothes or other fomites, or in food like milk. The disease can be transmitted by direct inoculation. The poison is tenacious and of extreme vitality ; infected clothes, unused for years, have led to outbreaks. The young are especially predisposed, but not equally so. Puerperal women and persons suffering from wounds are unusually susceptible. One attack does not give absolute immunity, but second attacks are uncommon. Pathology.—The throat is inflamed and sometimes ulcer- ated ; the liver and spleen are engorged ; the muscles reveal granular degeneration. Klein has observed hyperaemia and cell-proliferation, not only in the throat and kidneys, but scarlet fever. 257 throughout the intestinal canal. The kidneys frequently show the lesions of hemorrhagic nephritis, the glomeruli being espe- cially involved. The rash is rarely detected after death. Varieties.—(1) Simple; (2) anginoid ; (3) malignant. Period of Incuration.—A few hours to a week. Symptoms.—The disease generally begins suddenly, occa- sionally with a chill, but more commonly with vomiting or convulsions. Throat Symptoms.—Pain and difficulty in swallowing ; ful- ness and tenderness beneath the jaw ; enlargement of the lymphatic glands. The tongue is at first heavily coated and red at the tip and edges; in a few days the coating almost entirely disappears, and the papillae become bright red and swollen. This appearance has given rise to the term " straw- berry tongue." The pillars, tonsils, uvula, and pharyngeal vault are deeply injected and may reveal a punctiform efflo- rescence before the rash develops on the skin. In severe cases the tonsils may be the seat of follicular inflammation, or may be covered with false membrane. Eruption.—A scarlet-red punctiform rash appears at the end of the first, or at the beginning of the second day, on the neck and chest, and rapidly spreads over the entire body. It dis- appears on pressure, a white line remaining for a second or two when the finger-nail is drawn through it. It may be uniform or it may occur in discrete patches surrounded by healthy skin. In five or six days the red color gradually fades and scaly desquamation soon follows. In some cases the rash is pale and scarcely visible, in others it is slightly papular or vesicular (scarlatina miliaris); in ma- lignant cases it may be petechial. Febrile Symptoms.—The fever rises abruptly, reaching its maximum (104°-105°) in twenty-four or forty-eight hours, remains nearly uniform for three or four days, and then falls by lysis. The duration of the febrile period is from seven to nine days. The pulse is very rapid,—out of proportion to the fever; the respirations are hurried; the appetite is lost; the bowels are constipated; and the urine is scanty, high-colored, and often contains albumin. 17 258 ACUTE INFECTIOUS DISEASES. Nervous Symptoms.—Restlessness, headache, insomnia, de- lirium, and convulsions may occur in the course of the disease. Convulsions developing late in the disease are very significant of uraemia. Anginoid Scarlet Fever.—This form is characterized by severe throat symptoms. The tonsils are much swollen and are often covered with false membrane. The fever is high and the prostration is profound. Ulceration of the throat fre- quently occurs. Death may result from exhaustion, aspiration- pneumonia, or from hemorrhage due to ulceration of the carotid artery. Malignant Scarlet Fever—The onset is abrupt, with a chill, vomiting, or convulsion ; the fever is very high (106°-107°) ; the pulse is rapid and feeble; delirium sets in, and is followed by coma. Death may result before the appearance of the rash, in twenty-four or forty-eight hours. Complications. Nepjhritis.—This usually develops during convalescence, and as it may be unassociated with subjective symptoms the urine should be examined daily in order to de- tect its presence; in other cases its advent is recognized by the suppression of urine, by uraemia, or by dropsy. Nephritis may be the immediate cause of death, but more commonly it ends in recovery ; it sometimes leads to chronic renal disease. Among other complications may be mentioned hyperpyrexia, endocarditis, pericarditis, pneumonia, suppuration of the lym- phatic glands, ophthalmia, inflammation of the middle ear, chorea, and a peculiar inflammation of the joints resembling rheumatism. Diagnosis.—Acute Tonsillitis may resemble scarlet fever, especially when the former is associated with an erythematous rash; but in tonsillitis there is no history of contagion, the pulse is proportionate to the fever; the rash, if present, is not punctiform; the tongue has not the strawberry appearance; and there is no tendency to nephritis. Diphtheria.—The onset is less abrupt; there is more pros- tration ; false membrane is always present; a cutaneous rash is usually absent; and the tongue does not present a straw- berry appearance. Measles.—The sore throat is less marked ; catarrhal symp- toms are present; the rash appears later, is papular, and forms SCARLET FEVER. 259 in crescentic-shaped patches ; the fever shows a decided remis- sion on the second or third day ; and the pulse is proportionate to the fever. Rotheln.—This may be difficult to distinguish from scarla- tina, but the fever is not so high, nor the pulse so rapid; the post-cervical glands are more swollen; there is no tendency to nephritis; and if desquamation occurs it is branny. Accidental Rashes.—Certain drugs like belladonna, quinine, and copaiba, and certain foods, like crabs and oysters, may produce a rash like that of scarlet fever, but it is not puncti- form, and is not associated with high fever, sore throat, and rapid pulse. Prognosis.—Always guarded. The mortality varies in different epidemics from 5 to 40 per cent. Treatment. — Isolation. Absolute rest. Liquid diet. The surface of the body should be anointed two or three times daily with cold cream, cocoa-butter, or carbolized vaseline. The patient should be encouraged to drink water or lemonade freely. Gastric irritability may call for small doses of calo- mel, bismuth, or nitrate of silver. When the stomach is retentive, the tincture of the chloride of iron may be given with small doses of dilute hydrochloric acid, thus :— $.. Tinct. ferri chlor., f^ij ; Acid, hydrochlor.dil., f^j ; Syr. limonis, f &j; Aquae, q. s. ad f^iij.—M. Sig.—Teaspoonful in water every two or three hours. The fauces and pharynx should be kept clean by antiseptic washes or sprays, such as Dobell's solution, dilute peroxide of hydrogen, or dilute listerine. Cerebral symptoms may be controlled by bromide of potas- sium, chloral, by an ice-bag to the head, or, when due to fever, by the cold bath. High fever is best treated by sponging, by the cold pack, or by the graduated cold bath. The urine should be examined daily for evidence of ne- phritis, and, if the latter arises, the diet should be cut down to skimmed milk or buttermilk ; dry cups may be applied to the loins; the bowels kept active by Epsom or Rochelle salt; and diaphoresis encouraged by small doses of jaborandi. 260 ACUTE INFECTIOUS DISEASES. Cardiac weakness will call for stimulants like alcohol, am- monia, strychnia, and digitalis. Convalescence should be guarded and protracted. MEASLES. (Rubeola, Morbilli.) Definition.—An acute contagious disease, characterized by catarrh of the respiratory tract, moderate fever, and a red papular eruption, which appears on the fourth day and termi- nates in two or three days by branny desquamation. Etiology.—Measles is highly contagious, and the poison may be transmitted through clothes and other fomites. The contagium is apparently associated with the nasal and bron- chial secretion, but it has not been isolated. It is most commonly observed in children, but unprotected adults are very liable to be attacked. It is essentially an epidemic dis- ease, but now and then sporadic cases occur. One attack is fairly protective, but does not give absolute immunity. Pathology.—The lesions consist in catarrh of the entire respiratory tract. Gastro-intestinal catarrh is not uncommon. In fatal .cases such complications as capillary bronchitis, catarrhal pneumonia, and pulmonary collapse are frequently observed. Period of Incubation.—About two weeks. Symptoms. Prodromes.—Chilliness, coryza, watering of the eyes, photophobia, cough, and drowsiness. The Fever.—The temperature rises rapidly to 102° or 103°, but on the second day there is a decided remission which continues until the fourth day, when the eruption appears ; at this time it again rapidly runs up to, or beyond, its original height where it remains for two or three days and then falls by crisis. The Catarrh.—Redness of the conjunctivae, lachrymation, sneezing, hoarseness, cough, and expectoration. There may be vomiting or diarrhoea. The Eruption.—This appears about the fourth day on the face, and rapidly spreads over the entire body. It is com- posed of small, dark-red, velvety papules, which form groups MEASLES. 261 having crescentic borders. Red spots are frequently noticed on the pharynx before the eruption develops on the skin. In two or three days the eruption begins to fade, and branny desquamation soon followrs. Malignant, or Hemorrhagic Measles.—This form occurs under bad hygienic conditions, and is characterized by a pete- chial rash, by hemorrhages from the mucous membranes, and by profound prostration. • Complications and Sequelje. — Capillary bronchitis, catarrhal pneumonia, tuberculosis, otitis, gastro-intestinal catarrh, cancrum oris, and paralysis. Diagnosis. Rotheln.—Prodromes are often absent; fever and catarrh are slight; sore throat is marked. The rash appears on the first or second day as a diffuse red blush, or as small pale-red spots which do not form crescentic-shaped patches ; desquamation is scarcely noticeable. Scarlet Fever.—The fever is high and lacks the pre-emptive remission ; sore throat is present instead of general catarrh; the eruption appears on the first or second day as a diffuse punctiform rash; the pulse is out of proportion to the fever; and there is much greater tendency to nephritis. Prognosis.—Guardedly favorable. Complications are apt to occur and render the prognosis grave. Treatment.—Isolation. A darkened well-ventilated room; absolute rest. A liquid diet. Such refrigerant remedies as sweet spirits of nitre and liquor ammoniae acetatis are indicated and may be combined with a little aconite. fy Spt. oether. nitrosi, f^ss ; Liq. amnion, acetatis, q. s. ad f^iij.—M. Sig.—A teaspoonful every two hours. For the bronchial catarrh, apply a cotton jacket to the chest and give internally expectorants with sedatives like paregoric or bromide of potassium. K Liq. potass, citrat., f^iss ; Tinct. opii camph., f^iij ; Syr. ipecac, f£j ; Syr. acaciae, f.^ss; Aqua?, q. «. ad f.^iij.—M. gig,—A dessertspoonful every two hours for a child of five years. 262 ACUTE infectious diseases. Gastric irritability should be relieved by small doses of bis- muth or by calomel and soda. During desquamation the skin should be anointed two or three times daily. High fever is best controlled by sponging with tepid water. During con- valescence nutrients like cod-liver oil and malt, and tonics like iron, quinine, and strychnia are indicated. ROTHELN. (Rubella, German Measles, Epidemic Roseola.) Definition.—An acute contagious disease resembling both scarlet fever and measles, but differing from these in its short course, slight fever, and freedom from sequelae. Etiology.—The disease is highly contagious, and the poison may be carried on clothes or other fomites. It gener- ally occurs in epidemics, but sporadic cases are not uncommon. It is most frequently observed in children, but unprotected adults are not exempt. One attack usually protects from another, but not from measles or scarlet fever. Period of Incubation.—About two weeks. Symptoms.— Prodromes are slight, or altogether absent. The disease begins with drowsiness, slight fever, and sore throat. The eruption appears on the first or second day, and varies considerably in its character. In some cases the rash is composed of pale-red, scarcely elevated papules, which are more or less discrete (rubella morbilliforme) ; in others the rash is bright red and diffuse like that of scarlet fever (rubeUa scar- latiniforme). It begins on the face and rapidly spreads over the entire body, but it fades so rapidly that the face may be clear before the extremities are affected. Slight desquamation frequently follows, though it is often absent. Apart from the sore throat, the catarrhal symptoms are slight. The super- ficial cervical and posterior auricular glands are more swollen than in measles. The duration is from three to five days. Prognosis.—Good. Complications are rare. Treatment.—Rest. Liquid diet. Refrigerants. Spong- ing with tepid water. SMALLPOX. 263 SMALLPOX. (Variola.) Definition.-—An acute contagious disease, characterized by vomiting; lumbar pains; au eruption which is at first papular, then vesicular, and finally pustular; and by fever which is marked by a distinct remission beginning with the advent of the eruption, and lasting until the latter becomes pustular. Etiology.—The poison of smallpox is extremely tenacious; it may remain latent in clothes or other fomites for a long time, and then be capable of exciting the disease. The virulent principle is doubtless contained in the pustules and in all the excretions of the body, but it has not been isolated. Unless protected by vaccination or a previous attack, nearly every one is susceptible, from the aged to the child in utero. The colored race seem especially predisposed. Pathology.—The eruption consists in an infiltration of cells into the rete mucosum or into the true skin. The cells ultimately undergo ~ liquefaction-necrosis, when suppuration soon follows. Genuine pocks are frequently found in the molith, oesophagus, and larynx, and rarely in the stomach, trachea, and bronchi. The spleen is engorged. The organs and muscles reveal fatty and parenchymatous degeneration. Varieties.—Discrete; confluent; malignant; varioloid. Fig. 21. Temperature Curve in Smallpox. Symptoms. Discrete Smallpox. — The disease usually begins with a chill or series of chills, followed by vomiting and intense lumbar pains. The fever rises rapidly, reaching its 264 ACUTE INFECTIOUS DISEASES. maximum (104°-105°) in forty-eight hours, and continues high until the third or fourth day, when it falls several degrees ; this remission lasts until the seventh or eighth day,—that is, the time of pustulation,—when it again rises. The secondary or suppurative fever shows marked fluctuations ; its height is proportionate to the number of pustules ; and it falls by lysis about the eighteenth day of the disease. The pulse is full and ^irapid (120-140) ; the breathing is hurried; the skin is dry; the bowels are usually constipated, though diarrhoea is not un- common ; and the urine is scanty and frequently albuminous. The Eruption.—About the third or fourth day small red spots are noticed on the forehead, face, and wrists; these are rapidly converted into smooth round papules which feel like shot under the skin. The eaiption rapidly spreads over the entire body. About the third day the papules are converted into clear vesicles, which present a depression or umbilication at their summit. They are also loculated, i. e. divided into compartments by fibrinous partitions, so that when pricked with a needle all of the contained fluid does not escape. In two or three days the clear fluid becomes turbid and the vesicles are gradually converted into pustules. The latter soon lose the umbilicated appearance. Between the lesions the skin is oedematous, so that the body is swollen and the features are unrecognizable. In three days more the pustules dry up, or break and form soft yellow crusts which exhale a peculiar, offensive odor; they adhere to the skin for a week or more. When the scabs fall off, scars, or pock-marks generally remain, constituting a permanent deformity. At the beginning of the disease, before the true variolous eruption appears, either a red blush or a macular rash is often observed on the inner side of the arms and thighs. Confluent Smallpox.—The papules are abundant, and soon coalesce. The extremities are swollen and painful. The secondary fever is very high and irregular. True pocks nearly always develop in the air-passages and give rise to a copious fetid discharge from the nose and throat, to. hoarseness, and to cough. Delirium, stupor, and subsultus are frequent symp- toms. If the patient recovers, it is after a tedious con- SMALLPOX. 265 valescence, with great facial disfigurement, and often with defective vision and hearing. Malignant Smallpox.—In some cases the disease is ushered in with high fever, lumbar pains, and great prostration. Soon ecchynioses appear on the skin ; bleeding from the mucous membranes follows ; and death results before a true variolous rash appears. In other cases the disease advances like or- dinary smallpox up to the pustular stage ; then the pustules become effused with blood, and bleeding from the mucous membrane follows. This form is also very fatal. Varioloid.—This is modified smallpox occurring in one who has been partially protected by previous vaccination. The symptoms are mild; the eruption resembles that of common smallpox, but is usually very scant; secondary fever is absent. Complications and Sequelae.—Broncho-pneumonia; pleurisy ; inflammations of the eye (keratitis, iritis, conjunc- tivitis) ; otitis ; arthritis ; and boils. Diagnosis. Varicella.—The symptoms are milder; pro- dromes are generally absent; the eruption appears earlier, is more superficial, lacks an inflammatory areola, and is not umbilicated. Secondary Syphilis.—The history; the absence of fever; the symmetrical distribution of the eruption; its dark- coppery color; its polymorphous character (papules, vesicles, and pustules associated in a limited area) ; and the absence of itching will indicate syphilis. Prognosis.—This depends upon the virulence of the epi- demic, the degree of protection by vaccination, and the amount of the eruption. In discrete cases, it is generally favorable ; in the confluent, grave ; in the malignant, almost hopeless. Treatment.—The prophylactic treatment consists in vac- cination. The Attack.—Isolation. Every precaution must be taken to prevent the spread of the disease. The other members of the family should be vaccinated at once. The room should be cool and well ventilated. The diet must be liquid or semi- liquid, and may consist of milk, meat broths, eggs, etc. The free use of water, lemonade, or soda-water should be encouraged. 266 ACUTE INFECTIOUS DISEASES. The intense lumbar pains should be relieved by opium and the application of hot-water bags. Gastric irritability may call for bismuth or calomel and soda. The naso-pharynx should be kept clean by antiseptic washes and sprays, and Dobell's solution, dilute listerine, or dilute peroxide of hydrogen may be used for this purpose. The eyes must be kept clean by being washed several times a day with a saturated solution of boric acid. Stimulants are often indicated. High fever may be controlled by antipyrin or phenacetin, or by the cold pack or cold bath. The prevention of Pitting.—The room should be darkened, and the exposed parts covered with cloths soaked in dilute carbolic acid or bichloride of mercury, or with masks upon which has been spread some simple ointment, as one of mercury or of zinc. Unfortunately, when the lesions are deeply situ- ated there is no means of preventing pitting. The separation of the scabs may be facilitated by the use of warm baths. VARICELLA. (Chicken-pox.) Definition.—An acute contagious disease of short duration, characterized by slight fever and a discrete vesicular eruption, which disappears in two or three days by desiccation. Etiology.—The disease occurs sporadically and epidemi- cally. It is observed chiefly in children, but adults are not exempt. One attack usually protects from others. It bears no relation to smallpox. Period of Incubation.—One to two weeks. SvMPTOMS.--Slight fever and the appearance of a vesicular eruption within the first twenty-four hours. The vesicles ap- pear in crops over two or three days ; they are superficial, not umbilicated, and lack the red areola which is seen around the vesicle of variola. They rarely become pustular, and are only occasionally followed by scars. The duration is about a week. Diagnosis. Smallpox.—The slight fever; the absence of lumbar pains; the early appearance of the eruption ; aud the absence of the shot-like feel, umbilication, and red areola will serve to distinguish varicella from smallpox. VACCINIA. 267 Prognosis.—Always favorable. Treatment.—Rest in bed. A light diet. The application of some sedative lotion or ointment to allay itching and to pre- vent scratching. VACCINIA. (Vaccination, Cow-pox.) Definition.—A general disease with a local manifestation resembling the pock of variola, and acquired by inoculation with the virus of cow-pox. History and Object.—The value of vaccination as a means of protection against smallpox was first made known to the world in a paper published by Edward Jenner in 1798. Recent vaccination gives almost complete immunity from variola; the mortality of smallpox acquired after vaccination is almost inversely proportionate to the number of true vac- cine scars. Etiology.—Aacciuia is induced by inoculating the arm with fresh virus obtained from the udder of a calf suffering from cow-pox (bovine virus), or from the vesicle of a patient who has already been vaccinated (humanized virus). The former is preferable on account of the readiness with which the fresh article can be obtained, and on account of its freedom from other poisons, like syphilis. Time of Performance.—The first vaccination should be made about the third month, the second at the seventh year, and the third at puberty. It should always be repeated when smallpox is prevalent. Performance of Vaccination.—The arm should be ren- dered aseptic, and the skin scratched with a lancet or with the ivory point containing the lymph until red serum begins to ooze, when the moistened virus should be carefully worked in. The spot must be carefully protected from the clothes until thoroughly dry. Symptoms.—About the second or third day after the opera- tion a papule surrounded by a red areola forms at the seat of inoculation. In two or three days the papule is converted into a clear vesicle, which is umbilicated at its summit; the 268 ACUTE INFECTIOUS DISEASES. surrounding tissues are red, tender, and considerably infiltrated. About the seventh or eighth day the vesicle becomes a pustule; this lasts until the twelfth day, when it dries up and forms a scab, which separates during the third week and leaves behind a pitted scar. During the course of the eruption there are slight fever, malaise, restlessness, and enlargement of the axillary glands. Complications.—Erysipelas, abscess, and various cutaneous eruptions. Syphilis has occasionally been transmitted through humanized virus. ERYSIPELAS. (St. Anthony's Fire.) Definition. — An acute contagious disease excited by streptococci, and characterized by a peculiar inflammation of the skin and subcutaneous tissue, irregular fever, and a ten- dency to relapse. Etiology.—The disease is somewhat contagious and the poison can be carried in fomites. Certain families and certain individuals seem particularly predisposed. Puerperal women and wounded persons are very susceptible. Diseases which lower the vitality, especially Bright's disease, predispose. One attack does not protect against a recurrence, but rather favors it. Erysipelas was formerly divided into traumatic and idio- pathic varieties; but the two are identical, and it is probable that in those cases in which there is no conspicuous wound there is a slight abrasion through which the poison gains ad- mittance. The exciting cause is doubtless the streptococcus pyogenes. Pathology.—Erysipelas most frequently manifests itself on the face. The part is bright red in color, swollen, in- durated, and sharply circumscribed. The various strata of the skin are infiltrated with serum, and leucocytes and streptococci are found in the lymph-spaces. In severe cases the inflam- matory products are converted into pus, and abscesses form. Period of Incubation.—Three to seven days. Symptoms.—Prodromes are sometimes present, and consist of slight fever, chilliness, malaise, tingling of the part to be ERYSIPELAS. 269 affected, and sometimes enlargement of neighboring lymphatic glands. In many cases the disease is ushered in suddenly with a chill, followed by pain in the head and limbs and a high, irregular fever. The temperature may reach 103° or 104° in twelve or twenty-four hours. The pulse is full and rapid ; the tongue is heavily coated ; the appetite is lost; the bowels are constipated ; and the urine is scanty and often slightly albuminous. Local Phenomena.—The inflammation usually begins in the neighborhood of the nose, and spreads upward and laterally over the head to the neck, where it frequently stops. The affected part has a crimson hue; it is swollen and tense, and frequently ends in a sharply-defined ridge, beyond which, however, pro- jections can be felt advancing into the subcutaneous tissue. The surface of the inflamed patch is at first smooth and glazed, but later it is covered with minute vesicles or blebs. The patient complains of burning and tingling ; the surrounding parts are extremely oedematous, so that the features may be scarcely recognizable. In four or five days the redness begins to fade and the swelling to subside; desquamation follows; the general symptoms improve; and the fever falls by crisis. The average duration is from a week to ten days. Relapses are extremely common. Erysipelas Ambulans.—Sometimes the inflammation disap- pears in one place and reappears in another, and so continues indefinitely. In such cases typhoid symptoms, such as mut- tering delirium, a brown, fissured tongue, and subsultus ten- dinum, develop. Complications. — Inflammation of serous membranes (pericarditis, pleuritis, meningitis), oedema of the larynx, ne- phritis, hvperpyrexia, ulcerative endocarditis, and septicaemia. Diagnosis. Erythema. — The absence of high fever, of marked swelling, and of an abrupt ridge will serve to dis- tinguish erythema from erysipelas. Acute Eczema.—The swelling is less marked ; the itching is intense ; the swel'ing and redness are not circumscribed, but shade gradually into healthy tissue ; and there is no fever. Prognosis.—In the robust the prognosis is favorable. In the old, in alcoholic subjects, and in those suffering from 270 ACUTE INFECTIOUS DISEASES. chronic nephritis, the prognosis must be guarded. Ambulatory erysipelas may kill by exhaustion. Treatment.—Isolation ; absolute rest; a nutritious diet. It is well to begin the treatment with a saline or mercurial laxative. The tincture of the chloride of iron seems to exert a beneficial influence; it may be given in doses of twenty drops every two hours. Quinine (gr. v thrice daily) is also useful. When there is much restlessness and insomnia, bro- mide of potassium, chloral, or opium may be administered. Local Treatment—One of the following applications may be employed: Cloths wrung out in a solution of bichloride of mercury (1-5000), or in a saturated solution of boric acid, or in lead-water and laudanum ; a dusting powder of starch and oxide of zinc; or an ointment of ichthyol. $. Plumbi acetatis, 3j ; Tinct. opii, f 3J ; Aquie, q. s. Oj.—M. Sig.—Shake well and apply on lint. Or— fy Ichthyol, |ss ; Vaselin., § ij.—M. Sig.—Spread thickly on lint and apply to the affected part. The injection of antiseptic remedies around the inflammatory patch, with the view of preventing its spread, is very painful and rarely necessary. YELLOW FEVER. Definition.—An acute infectious disease, characterized by jaundice, epigastric tenderness, vomiting, hemorrhages, and a febrile course consisting of two paroxysms. Etiology.—A hot climate and a warm season, salt water, bad drainage, and overcrowding favor the development of epidemics. The disease is not distinctly contagious; the poison probably undergoes some changes outside of the body, and is carried through the atmosphere, clothes, or other fomites. The colored race are less susceptible than the white. Strangers in an infected district are more liable to be YELLOW FEVER. 271 attacked than residents. One attack usually confers immunity from others. Pathology.—The tissues are stained yellow by disin- tegrated blood (hematogenous jaundice). The liver is pale and is the seat of extensive fatty degeneration. The gastric mucous membrane is swollen, congested, and frequently ecchy- mosed. The spleen is not enlarged. The heart is pale and flabby. Thokidneys are generally the seat of parenchymatous . inflammation. Period of Incubation.—A few hours to a week. Symptoms. First Stage.—The disease begins with a chill, followed by pain in the head, back, and limbs. The tempera- ture rises rapidly until it reaches its maximum (103°-105°). The face is flushed, the conjunctivae are injected, and the pupils small; the tongue is coated, the epigastrium is tender, the stomach is irritable and unretentive; the bowels are con- stipated ; and the urine is scanty and albuminous. This stage lasts from a few hours to several days, and is followed by a marked fall in the temperature and an improvement in the general symptoms (stage of remission). At this time con- valescence may begin, or the patient may pass into the second febrile paroxysm. Second Stage.—The fever rises to its original height; the skin becomes yellow; vomiting is persistent, and the ejected material may contain dark blood (" black vomit"). Hemor- rhages sometimes occur from other mucous membranes. The pulse is rapid, though not proportionate to the fever. The urine becomes very scanty and contains albumin and casts. Death frequently results from exhaustion or ursemia, though recovery may follow the gravest symptoms. Duration.—From a few hours to a week. Diagnosis. Relapsing Fever.—This is distinguished by the enlargement of the spleen, the multiple paroxysms, the spirilli in the blood, and the absence of black vomit. Acute Yellow Atrophy of the Liver.—The early appearance of jaundice, the diminution in the size of the liver, the slight fever, the marked cerebral symptoms, and the presence of leucin and tyrosin in the urine will indicate acute yellow atrophy. 272 ACUTE INFECTIOUS DISEASES. Remittent Fever.—This may be distinguished by the enlarge- ment of the spleen, the multiple remissions, the presence in the blood of haematozoa of Laveran, and by the absence of black vomit. Prognosis.—Always grave. The average mortality in different epidemics is from twenty to seventy per cent. In individual cases, high fever, severe cerebral symptoms, black vomit, and suppression of urine are unfavorable features. Treatment.—Absolute rest. A cool, well-ventilated room. A liquid diet. The pains in the back and limbs may be re- lieved by hot-water bags and the administration of morphia. For the gastric irritability a mustard plaster may be applied to the epigastrium, and cracked ice, iced champagne, carbolic acid, or small doses of calomel may be given internally. Stim- ulants are frequently indicated. Quinine may be given by the rectum. High fever is best controlled by th'e external application of cold. The black vomit results from blood- dyscrasia, and while such remedies as gallic acid, Monsel's solution, ergot, and turpentine are recommended, they usually prove useless. ACUTE GENERAL TUBERCULOSIS. (Acute Miliary Tuberculosis.) Definition.—An acute infectious disease excited by the tubercle bacillus, and characterized anatomically by the simultaneous formation of miliary tubercles in many parts of the body. Etiology.—The disease usually develops in early adult life. Certain infectious diseases like measles, whooping-cough, and typhoid fever seem to predispose. General tuberculosis is almost always secondary to local tuberculosis—pulmonary phthisis or a scrofulous lymphatic gland. The bacilli are probably disseminated by the veins. Pathology.—All the organs may be uniformly infiltrated with discrete tubercles, but more commonly certain organs, ■ like the brain and lungs, are more affected than others. Symptoms.—Debility; loss of flesh and strength; fever moderately high (102°-104°), irregular, and marked by evening acute general tuberculosis. 273 exacerbations and morning remissions; cough ; hurried respi- rations ; a brown, fissured tongue; a weak, rapid pulse; en- largement of the spleen; delirium ; subsultus tendinum ; and stupor. Tubercle bacilli are rarely found in the expectoration or in the blood. The duration is from two to four weeks. When the lungs are chiefly affected there are : Dyspnoea, marked cough, muco-purulent and bloody expectoration, cyanosis, sibilant and subcrepitant rales, and perhaps areas over which bronchial breathing is detected. When the meninges are chiefly affected there are: Intense headache, convulsive seizures, photophobia, delirium, facial palsies, stupor, coma, and Cheyne-Stokes breathing. Tubercles may be detected on the retina. When the intestines and peritoneum are affected there are : Pain, tenderness, abdominal distention, and diarrhoea. Diagnosis.—The disease closely resembles typhoid fever, and there is no doubt that the mortality of the latter is en- hanced by included cases of unsuspected general tuberculosis. The following table will indicate the points of distinction :— Typhoid Fever. Epistaxis common. The temperature rises gradually, and runs a regular course. Diarrhoea is frequent. An eruption is generally present. Xo tubercles on the retina. Respirations are hurried. Facial palsies are rare. I Common. Prognosis.—Always fatal. Treatment.—Palliative. The diet should consist of milk, eggs, and broths. Stimulants are indicated. High fever should be controlled by antipyrin or by the external applica- tion of cold. Acute General Tuber- culosis. Infrequent. The temperature usually rises abruptly, and runs a very ir- regular course. Infrequent. Rarely present Occasionally detected. Still more hurried. 18 274 acute infectious diseases. DIPHTHERIA. (Diphtheritis, Malignant Sore Throat, Cynanche Contagiosa.) Definition.—An acute contagious disease excited by the Klebs-Lofler bacillus, and characterized by moderate fever, glandular enlargements, great prostration, and a fibrinous exu- dation which is usually located in the throat. Etiology.—Childhood (between three and six), defective drainage, and catarrhal conditions of the throat are predispos- ing factors. The poison is contained in the secretions of the throat, and may be transmitted through the atmosphere or through fomites. One attack does not protect from another, but rather predisposes. The exciting cause is the Klebs-Lofler bacillus, which is found only in the membranous exudation. The constitutional symptoms result from the poison generated by the bacillus. Pathology.—The false membrane is usually found on the tonsils, pillars, and pharynx, but it may extend to the mouth, larynx, or nose. The bacillus coming in contact with the throat leads to the death of the superficial cells, which ulti- mately undergo coagulation-necrosis. The irritation causes a migration of leucocytes, and these undergo a similar necrosis. The membrane thus formed is of a grayish-white color, and is more or less adherent, so that when torn off it leaves a raw surface. Sometimes the necrosis extends to the deeper tissues and causes widespread ulceration and even gangrene. Micro- scopically, the pseudo-membrane is composed of fibrin, leuco- cytes, bacteria, and the remains of epithelial cells. The lym- phatic glands are considerably swollen. The spleen is engorged. The various organs and the muscles reveal fatty and parenchymatous degeneration. Examination of the lungs frequently shows capillary bronchitis, catarrhal pneumonia, and collapse. In some cases the blood is dark and fluid, while in others firm clots are often found within the heart. Types.—Diphtheria may be divided according to the loca- tion of the exudate into: (1) Faucial; (2) laryngeal; (3) nasal; (4) cutaneous. According to the severity of the attack it may be divided into : (1) Mild; (2) grave; (3) malignant. diphtheria. 275 Period of Incubation.—Two to ten days. Symptoms. Faucial Diphtheria.—The disease commonly begins with chills, moderate fever, malaise, and sore throat. The fever, as a rule, is not very high (102°-104°) and its course is quite irregular. The pulse soon becomes rapid and feeble; the bowels are constipated; the urine is scanty and frequently albuminous; and the prostration and pallor are often out of all proportion to the severity of the febrile symptoms. Local Phenomena.—The child complains of difficult swallow- ing ; the muscles of the neck feel stiff; there is tenderness under the jaw ; the lymphatic glands are considerably swollen; and the fauces are covered with a grayish-white membrane which when stripped off leaves a raw bleeding surface, and is soon followed by a similar deposit. The membrane may spread to the nose or larynx. The course of the disease is indefinite, the average duration being from one to two weeks. Laryngeal Diphtheria.—This is usually secondary by exten- sion from the fauces, but it is occasionally primary. It is rec- ognized by hoarseness or aphonia, croupy cough, progressive dyspnoea, and stridulous breathing. The alae of the nose play ; the sterno-cleido-mastoids are prominent; the supra-sternal notch is deepened; and the base of the chest is retracted. Shreds of false membrane are sometimes expectorated in the violent fits of coughing. The febrile symptoms are usually slight. Death frequently results from suffocation, and recovery without operation is unusual. Nasal Diphtheria.—This is nearly always secondary. It is recognized by grave constitutional symptoms—high fever, marked glandular involvement, and great prostration ; by an offensive discharge from the nose; by epistaxis; and by ex- coriation of the lips. The false membrane may be detected on inspection. Cutaneous Diphtheria.—This form may be primary or secondary. The constitutional symptoms are similar to those of faucial diphtheria. Complications and Sequels.—Capillary bronchitis, catarrhal pneumonia, pulmonary collapse, endocarditis, heart- clot, nephritis, and paralysis.. 276 ACUTE INFECTIOUS DISEASES. Diphtheritic Paralysis.—This generally occurs during con- valescence and is observed in about fifteen per cent, of all cases. There is no relation between the severity of the attack of diphtheria and the liability to paralysis; mild cases, which are thought to be simple pharyngitis, are sometimes followed by troublesome paralysis. The pharynx is the most common seat, and the palsy is recognized by difficult swallowing and the regurgitation of liquids through the nose. Next in fre- quency the eyes are involved, and strabismus or ptosis de- velops. The heart may be affected, and if sudden death does not result, the condition may be manifested by a remarkable slowing of the pulse. The extremities are rarely paralyzed. The paralysis is due to a toxic neuritis. Diagnosis. Scarlet Fever.—The onset is more sudden; the fever is high ; the pulse more rapid ; the tongue presents a strawberry appearance; a red punctiform rash appears on the first or second day ; and membrane is not often found in the throat. Membranous Croup.—Laryngeal diphtheria is generally secondary to faucial diphtheria; it is contagious; it is often epidemic; it is associated with greater constitutional dis- turbance ; and it is more apt to be followed by sequelae. Prognosis.—Always guarded. The mortality varies in different epidemics from 10 to 50 per cent. When the con- stitutional symptoms are mild, and the membrane is confined to the fauces and shows little tendency to spread, the prognosis is quite favorable. Nasal diphtheria is always a grave disease. Laryngeal diphtheria proves fatal in 60 or 70 per cent, of all cases. Treatment.—Isolation. Absolute rest. A nutritious diet consisting of milk, koumiss, eggs, broths, and the like. Stimu- lants are nearly always required, and should be administered as soon as the pulse softens. Tonics like iron, quinine, and mineral acids are useful when well borne. Of the special remedies, mercury is the most reliable, and either calomel or the bichloride may be employed. I£ Hydrarg. chlor. mit., gr. j ; Sodii bicarb., gr. xxiv ; Pulv. aromat., gr. vj.—M. (Starr.) Et ft. in chart. No. xii. Sig.—One powder every two hours. DIPHTHERIA. 277 Or- !£. Hydrarg. chlor. corros., gr. j ; Spt. vini rect., f^ij ; Elix. bismuth, et pepsin., ad fgiv.—M. (J. Leavis Smith. ) Sig.—Teaspoonful every two hours for a child of six years. Iron may be given with the bichloride, as in the following mixture :— I£ Hydrarg. chlor. corros., gr. j ; Tinct. ferri chlor., Spt. vini rect., aa f3ij ; Syr. limonis, Aqure, aa f^ij. -M. Sig.—Teaspoonful every two or three hours for a child of six years. The atmosphere of the room should be rendered moist by slacking lime, by evaporating water on the stove or over a spirit-lamp, or by means of a steam atomizer. The addition of turpentine or of oil of eucalyptus to the water is often rec- ommended. Iodine, or an ointment of mercury, belladonna, or ichthyol, may be applied to the swollen and tender glands. The naso-pharynx should be kept clean by antiseptic sprays or douches, and one of the following may be selected for this purpose : Dobell's solution, dilute listerine, or dilute peroxide of hydrogen. Many solvents have been recommended; those most com- monly employed are dilute lactic acid, dilute hydrochloric acid with pepsin, a solution of papayotin, an alkaline solution of trypsin, and peroxide of hydrogen. The last is often ex- tremely useful, but it is essential that it should be fresh. !£. Hydrogen, dioxid., fgj ; Glycerin, f^ij ; Aquae destil., f.fss.—M. Sig.—Use as a spray or mop. When the throat is not too sensitive, the peroxide of hy- drogen may be employed undiluted. In laryngeal diphtheria, when these means fail, tracheotomy or intubation must be resorted to. 278 acute infectious diseases. WHOOPING-COUGH. (Pertussis.) Definition.— An infectious disease, characterized by catarrh of the respiratory tract and peculiar paroxysms of cough ending in prolonged crowing or whooping inspiration. Etiology.—The disease occurs both sporadically and epi- demically. It is most frequently met with in children, but unprotected adults are not exempt. The disease is unquestion- ably contagious, and the virus seems to be associated with the sputum. One attack protects from others. Pathology.—No characteristic lesions are observed after death. The poison excites an inflammation of the respiratory mucous membrane, and probably irritates the peripheral fila- ments of the pneumogastric nerve, and so causes the parox- ysmal cough. In fatal cases, pulmonary complications are usually discovered, such as catarrhal pneumonia, pulmonary collapse, and emphysema. Symptoms.—There are three stages: (1) The catarrhal stage; (2) the paroxysmal stage; and (3) the stage of decline. Catarrhal Stage.—The disease begins with the symptoms of coryza, and bronchial catarrh—slight fever, sneezing, running from the nose, dry cough, and rales. But it does not respond to the ordinary remedies for catarrh, and after lasting one or two weeks passes into the paroxysmal stage. Paroxysiwd Stage.—The cough becomes more violent and paroxysmal. During the paroxysm the face is cyanosed, the eyes are injected, and the veins distended. The cough fre- quently induces vomiting, and, in severe cases, epistaxis or other hemorrhages. The close of the paroxysm is marked by a long-drawn, shrill, whooping inspiration due to the spas- modic closure of the glottis. The number of paroxysms, or " kinks," varies from ten or twelve to forty or fifty in the twenty-four hours. From the forcible propulsion of the tongue against the lower incisors, an ulcer is frequently formed on the fraenum. The duration of this stage is three or four weeks. Stage of Decline.—The paroxysms grow less frequent and whooping-cough. 279 less violent and finally cease. Protracted cases are followed by anaemia and prostration. Duration.—The entire duration of the disease is from a few weeks to four months. Complications and Sequels.— Catarrhal pneumonia, pulmonary collapse, emphysema, hemorrhage into the conjunc- tiva, ear, or brain, and convulsions. Grave cases are some- times followed by chronic bronchitis, tuberculosis, or caucrum oris. Diagnosis.—This can rarely be made with certainty during the catarrhal stage. Later, the paroxysmal cough ending in vomiting or in whooping is absolutely diagnostic. Prognosis.—Guardedly favorable. Severe cases in the young and debilitated not infrequently prove fatal. Treatment.—The child should be clad in flannel under- clothes and carefully protected from changes of temperature. During the catarrhal or febrile stage the patient should be con- fined to bed. The diet should be light and nutritious. Coun- ter-irritants, like iodine, applied to the chest seem useful. Quinine is a reliable tonic and may be employed throughout the disease. The ordinary expectorant mixtures are valueless. Local applications to the respiratory mucous membrane give much relief. One of the following remedies may be inhaled : Creosote and chloroform, dilute peroxide of hydrogen, or a solution of menthol. I£ Menthol, gr. xx ; Petrolat. liquid., f£j.—M. Sig.—Spray the naso-pharynx and inhale several times a day. In very young children a solution of menthol may be in- haled from a cloth held under the chin. When paroxysms are violent the inhalation of a few drops of nitrite of amyl is de- sirable. The following antispasmodic remedies appear to lessen the severity and the frequency of the paroxysms : belladonna, anti- pyrin, asafoetida, and bromide of potassium. ]£. Sodii bromidi, ^iss ; Tinct. belladonna?, fgj ; Glycerini, f.^ss; Aquae, q. s. ad fsij.—M. Sitr,—A teaspoonful every three or four hours. 280 acute infectious diseases. Or— IJl Antipyrin, gr. xxxij ; Syr. tolutan., f^j ; Aquae q. s. ad f^ij.—M. Sig.—A teaspoonful every two or three hours. INFLUENZA. (La Grippe, Catarrhal Fever, Epidemic Catarrh.) Definition.—An acute infectious disease, characterized by fever, extreme prostration, pain in the head and back, and generally by catarrh of the respiratory or gastro-intestinal tract. Etiology.—The disease occurs in epidemics which usually have their origin in Russia, whence they spread with wonder- ful rapidity over both continents. The exciting cause is with- out doubt a small bacillus found in the sputum, and first dis- covered by Pfeiffer in 1892. When prevalent, no age and neither sex is exempt. One attack does not confer immunity from others. Pathology.—Influenza does not often kill save by its complications. The latter are most frequently associated with the respiratory tract, and consist of capillary bronchitis, catar- rhal pneumonia, and croupous pneumonia. Symptoms.—The disease begins abruptly with lassitude, malaise, chilliness, severe pain in the head and back, fever ranging between 101° and 103°, and extreme prostration, which is out of proportion to the fever and any existing local inflammation. The catarrhal symptoms are injection of the eyes, sneezing, hoarseness, and hard paroxysmal-cough. In simple cases the temperature falls in two or three days by crisis, but complications not infrequently prolong the case for several weeks. In some cases the catarrh of the respiratory tract is the chief feature ; in others the gastro-intestinal tract is attacked, and the symptoms resemble cholera morbus ; in a third group neuralgic pains in the head, back, and limbs are the most striking phenomena. Complications.—Catarrhal pneumonia, croupous pneu- monia, nephritis, neuritis, meningitis, and insanity. MUMPS. 281 Diagnosis. Acute Bronchitis.—The fever is not so high ; there is little or no prostration ; and the pains in the head and back are not nearly so marked as in influenza. Prognosis.—Uncomplicated cases nearly always recover. In the very old, and in those debilitated by chronic disease, influenza not infrequently proves fatal. Treatment.—Absolute rest iu bed and a liquid diet. As there is no specific, the treatment is symptomatic. Quinine is a useful stimulant, and when the stomach is irritable it may be given bv the rectum. The Pains. — Hot-water bags to the head and spine; morphia, or combinations of antipyrin or phenacetin with salol or salicin, thus :— fy Salol, Phenacetin, aa ^ss.—M. Ft. in chart. No. xii. Sig.—One every two hours. Or— ]£. Quininae salicylat., gr. xl; Phenacetin, gss.—M. In 20 capsules. Sig.—One every two hours. Or— ]£. Salicini, 3iij; Phenacetin, gr. xvj ; Olei gaulther., gtt. xv ; Syr. acacia?, f^vij.—M. (Curtin and Watson.) Sig.—Teaspoonful every hour or two. Heart-failure should be combated by alcohol and strychnia. Bronchial catarrh will require the remedies indicated in simple bronchitis. Sleep may be induced by opium, sulphonal, or bromide of potassium. MUMPS. (Epidemic Parotitis.) Definition.—An acute contagious disease, characterized by inflammation of the parotid and other salivary glands. Etiology.—The disease occurs sporadically and epidemi- cally. It is most frequently observed in young children, but 282 acute infectious diseases. unprotected adults are not exempt. Males are more suscep- tible than females. The disease is highly contagious, and the virus is probably contained in the saliva, but it has not been isolated. One attack confers immunity from others. Pathology.—As the disease is so seldom fatal very little opportunity is afforded for studying its intimate pathology. The parotid glands are the seat of an inflammatory infiltration, but suppuration does not occur. The inflammation shows a marked tendency to leave the parotids and to involve the testes in the male, or more rarely the mammae or ovaries in the female. Period of Incubation.—One to two weeks. Symptoms.—The disease is ushered in with chilliness, mal- aise, and moderate fever (101°-104°), followed by swelling of one parotid gland. The swelling is observed below and in front of the ear, is pyriform in shape, and has a doughy feel. The surrounding tissues are oedematous, the submaxil- lary glands are likewise swollen, and the features may be dis- torted beyond recognition. The movements of the jaw are restricted and painful. The saliva may be increased or di- minished. In many cases the other parotid becomes similarly affected. Often in the course of the disease the inflammation suddenly subsides in the parotid gland and reappears in the testicle in the male, or in the ovary or mamma in the female. The duration of the disease is usually five or six days. Complications.—Hyperpyrexia, metastasis to the testicle or ovary, and meningitis. Atrophy of the testicle rarely follows. Prognosis.—Favorable. Treatment.—Pest in bed. Mild febrifuges may be given internally. Locally, lead-water and laudanum, or some rube- facient liniment like the following, may be employed :— R Tinct. iodi, Tinct. aconit. rad., Tinct. opii, aa f^ij ; Liniment, chloroform., q. s. ad f^iij.—M. Sig.—Apply externally and cover with cotton-wool. The swollen testicle should be elevated and covered with lint saturated with lead-water and laudanum. If the swelling CHOLERA. 283 persists, an ointment of mercury, belladonna, and ichthyol will be found useful. CHOLERA. (Asiatic Cholera, Epidemic Cholera, Malignant Cholera.) Definition.—An acute infectious disease, generally epi- demic, excited by Koch's comma-bacillus, and characterized by vomiting and purging of a serous material, painful cramps, and collapse. Etiology.—Cholera has its origin in India, and is carried thence to other parts of the world. The exciting cause is the comma-bacillus of Koch; this usually has the form of a slightly-curved rod, but it is occasionally S-shaped. The rice- water evacuations only contain the bacilli, which, under favor- able conditions, continue to grow outside of the body, and by gaining entrance into the healthy system propagate the disease. The disease always spreads along the lines of traffic, hence epidemics nearly always begin at the sea-coast and ex- tend inland. Cholera is slightly, if at all, contagious ; like typhoid fever, the poison is not carried through air, but chiefly through drinking-water. Laundresses and nurses, from their contact with the evacuations, readily acquire the disease. Epi- demics are more frequent in summer than in winter. No age is exempt, but the old are more susceptible than the young. The intemperate, the debilitated, and those suffering with gas- tro-intestinal catarrh are especially predisposed. Pathology.—The body is shrivelled; movements of the corpse are sometimes observed ; rigor mortis is marked and prolonged. The tissues are dry, and the large veins and right side of the heart contain thick, dark blood. The serous cavi- ties are empty and their surfaces sticky. The intestines con- tain more or less rice-water fluid, from which cultures of bacilli can be made. The mucous membrane has a pinkish color and is often the seat of ecchymoses ; the solitary and Peyer's glands are swol- len. Frequently extensive desquamation of the epithelial lining is observed, but this is usually regarded as a post-mor- 284 ACUTE INFECTIOUS DISEASES. tem change. The kidneys reveal evidences of parenchymatous inflammation ; the liver is the seat of fatty degeneration. As the lesions are not sufficient to explain the clinical phe- nomena, it has been suggested by Koch that the bacilli create a poison the absorption of which causes the grave symptoms. Period of Incubation.—A few hours to several days. Symptoms.—The severity of the symptoms varies consider- ably. In well-marked, but favorable, cases there are three stages: (1) Invasion; (2) algid or collapse ; (3) reaction. Stage of Invasion.—The disease usually begins with malaise, headache, diarrhoea, rumbling noises in the intestines, and colic. Frequently these symptoms continue a few days and then subside; such cases are termed cholerine, and are as infec- tious as the fully-developed disease. Stage of Collapse.—The diarrhoea grows more marked; the evacuations become copious, lose their feculent character, assume a rice-water appearance, and are discharged forcibly but with- out pain. Vomiting soon develops, and the ejected material resembles that passed by the bowel. Thirst is unquenchable. Severe cramps seize the muscles of the calves of the legs, thighs, arms, and abdomen. The surface is cold and covered with a clammy sweat; the breath is cool; the temperature in the axilla ranges from 95° to 85°, while in the rectum it may rise to 103° or more. The voice is husky and finally reduced to a whisper; the respirations are quickened ; the pulse becomes more and more feeble ; the body is livid and shrivelled ; the hands resemble those of a washerwoman ; the features are pinched and sometimes distorted ; the eyes are frightfully sunken. The urine is more or less suppressed, and the little that is passed generally contains albumin and a trace of sugar. Consciousness is usually retained until near the end, when coma sets in. The duration of this stage is from a few hours to two days. Stage of Reaction.—Sometimes, even when death seems im- minent, the surface-temperature begins to rise ; the urine in- creases ; the pulse strengthens; the vomiting ceases • the evacuations from the bowels become less frequent and begin to assume a feculent character, and convalescence is established. Occasionally, instead of convalescence, symptoms of a typhoid CHOLERA. 285 type develop, such as moderate fever, a brown, fissured tongue, subsultus, muttering delirium, and coma. This condition, which is generally fatal, has been regarded as uraemic. Cholera Sicca.—In very violent cases collapse and death may follow without there having been any evacuation. After death the intestines contain rice-water fluid, which was not discharged during life probably on account of paralysis of the muscular coat of the bowel. Complications and Sequelae.—Nephritis, pneumonia, pleurisy, parotitis, ulceration of the cornea, diphtheritic in- flammation of the throat and fauces, abscesses, and local gan- grene. Diagnosis. Cholera Morbus.—This is always sporadic; the discharges are bilious in character; a history of dietetic errors and of exposure can usually be obtained; and the comma- bacilli are not detected in the discharges. Prognosis.—Generally unfavorable. The mortality aver- ages about 50 per cent. In the old, young, debilitated, and intemperate it is very fatal. In individual cases, early col- lapse and a low surface temperature are unfavorable conditions. Treatment. Prevention.—This includes the isolation of the sick; absolute cleanliness; the disinfection of excreta and soiled bed-clothes; the thorough boiling of all water that is to be used for drinking purposes; the use of a bland, unirritating diet; the avoidance of overwork, exposure, and undue excite- ment ; and the prompt treatment of any gastro-intestinal dis- turbance that may arise. The Attack.—The violent vomiting and purging and the cramps call for morphia; this is best administered hypoder- mically. There are no specifics. A remedy frequently recom- mended by competent observers is sulphuric acid, which may be given with laudanum or chlorodyne. Thirst is best assuaged by cracked ice ad libitum and acidulated drinks. For the vomiting a mustard poultice may be applied to the epigastrium, and iced champagne, carbolic acid, creosote, or dilute hydro- cyanic acid may be given internally. For the cramps the application of hot-water bags, warm fomentations, or the rub- bing in of warm oil may be useful; when they are very severe a few whiffs of chloroform may be employed. When the pulse 286 ACUTE INFECTIOUS DISEASES. weakens, stimulants like alcohol, ether, and ammonia should be given freely. Copious warm-water enemata containing tannic acid (1 per cent.) and laudanum are highly recommended for the purging. The low temperature must be combated by the use of hot blaukets, or, better still, by immersion in warm baths (98° to 104°). In collapse, subcutaneous or intravenous injections of saline solutions have been highly recommended. The follow- ing solution, which is well spoken of by Fagge, may be injected directly into the veins, or may be allowed to flow through a rubber tube attached to an aspirating canula, and to enter the subcutaneous tissue by its own pressure :— fy Sodii phos., gr. iij ; Sodii chlorid., 3j ; Potass, chlorid., gr. vj ; Sodii carb., gr. xx ; Alcohol, f^ij ; Aqua? destil., f^xx.—M. The fluid should be warm, and the injection should be con- tinued until the pulse strengthens; as much as eighty ounces may be introduced at one time. The diet should consist of the following : Light broths, milk with carbonated water, koumiss, wine-whey, thin gruels, and frozen blocks of beef-tea. TETANUS. (Lockjaw.) Definition.—An acute infectious disease excited by a special bacillus, and characterized by painful tonic spasms of the voluntary muscles. Etiology.—In the tropics, especially in the colored race, the disease often arises idiopathically. In temperate climates the poison nearly always gains entrance through a wound. Lacerated and punctured wounds, frost-bites, and burns are especially liable to become infected. Exposure to cold and wet after traumatism seems to predispose. Since the intro- duction of antiseptic surgery tetanus is less common than formerly. TETANUS. 287 The exciting cause is a special microorganism—the tetanus bacillus. Pathology.—Congestion of the spinal cord and of the nerves leading to the wound. Symptoms.—The disease begins with a feeling of rigidity in the muscles of the neck and lower jaw; by degrees the muscles of the back, abdomen, and lower extremities are similarlv involved. The brow is wrinkled, the corners of the mouth are drawn upwards (risus sardonicus), the jaws are tightly closed (trismus), and the body becomes arched, the patient resting on his head and heels (ojristhotonos). There is extreme hyperesthesia, so that the slightest touch causes a violent exacerbation of the spasm, which is attended by ex- cruciating pain. If the respiratory muscles are involved, there is intense dyspnoea. The temperature usually remains normal until just before death, when it may rise to 107° or more. The mind is dear to the end. The duration is from a few days to several weeks. Diagnosis. Strychnia-poisoning.—The history of the case, the complete relaxation between the spasms, and the late in- volvement, of the jaw will indicate strychnia-poisoning. Tetany.—The history, the paroxysmal character of the spasms, the involvement of the hands, and the escape of the trunk and jaw will serve to distinguish tetauy from tetanus. Prognosis.—Unfavorable. Slight involvement of the muscles of the trunk, absence of fever, and a slow course are favorable features. Treatment.—The wound should be rendered aseptic. Morphia is indicated for the relief of the pain. Bromide of potassium (3J every two hours) and chloral should be used to control the convulsions. When asphyxia is threatened by the violence of the spasm, inhalations of chloroform should be employed. When the patient is unable to swallow, he must be fed through the nose or by the rectum. Antitoxines derived from the blood of animals which have been rendered immune will doubtless prove to be a valuable addition to the therapy of this dread disease. 288 ACUTE INFECTIOUS DISEASES. DENGUE. (Break-bone Fever, Dandy Fever.) Definition.—An acute infectious disease, characterized by pains in the muscles and joints, a variable rash, and a febrile course of two paroxysms. Etiology.—Dengue is confined almost entirely to hot cli- mates. Although it occurs in epidemics, its*contagiousness is still a matter of dispute. Period of Incubation.—Three to five days. Symptoms.—The invasion is usually sudden and is attended with lassitude, chilliness, headache, intense pain in the muscles and joints, and high fever. The latter rises rapidly and often reaches a maximum of 104°-105° in a few hours. The pulse is rapid and full; the respirations are accelerated; the mind is often delirious; the urine is scanty ; the joints are swollen and stiff. In two or three days the temperature falls, and an afebrile period follows in which the patient is free from pain, but is profoundly prostrated. During the remission a roseo- lar or a diffuse erythematous rash generally appears; this lasts two or three days and is followed by slight desquamation. Shortly after the subsidence of the rash, the fever and pains again return, and persist for two or three days when conva- lescence begins. Diagnosis.—Acute rheumatism. The prevalence of an epidemic, and the distinct remission will usually render the diagnosis apparent. Prognosis.—Favorable. Treatment.—There is no specific remedy. High fever should be controlled by the external application of cold or by the use of antipyrin. Morphia, salol, antipyrin, or phenacetin may be employed to relieve pain. Prostration must be com- bated by stimulants, like alcohol, quinine, and strychnia. HYDROPHOBIA. (Rabies.) Definition.—A disease of dogs and kindred animals, com- municated to man by direct inoculation, and characterized by HYDROPHOBIA. 289 slight fever, painful spasm of the muscles of the throat, deli- rium, paralysis, and coma. Etiology.—Rabies invariably results from the bite of a rabid animal, generally a dog. In the animal the disease is characterized by depression of spirits, loss of appetite, followed by excitement, aimless roving, a morbid desire to bite, and finally by paralysis and death from exhaustion. The poison is contained in the saliva and blood. Pasteur has induced the disease by direct inoculation, and has found that the virus is attenuated by passing several times through the monkey. Bites on the face and on exposed parts-are more liable to be followed by infection. Pathology.—Intense congestion of the spinal cord and of the respiratory mucous membrane. Period of Incubation.—Six weeks to six months. Symptoms. First Stage.—Depression of spirits, restless- ness, slight difficulty in swallowing, and pain in the wound or cicatrix. In a few days the stage of excitement begins. Second Stage.—Clonic convulsions, involving especially the muscles of the throat, occurring spontaneously or excited by drinking or by the sight of water; hyperesthesia, delirium, moderate fever, and salivation. This stage lasts a few days, and is followed by paralysis. Third Stage.—The pulse weakens; the convulsions cease; the patient lies motionless; the mind becomes clouded ; and death results in twelve or twenty-four hours from exhaustion. Diagnosis.—Hysteria in persons who have been bitten may simulate hydrophobia. Such persons often bark, try to bite, and manifest other symptoms which are not noted in hy- drophobia. Prognosis.—Invariably fatal. Treatment. Prophylaxis.-—Suspicious bites should be thoroughly disinfected and cauterized by the hot iron or caus- tic potash, after which the patient should be sent to an institute where inoculation may be practised after the method of Pasteur. The Attack.—Palliative. For the convulsive seizures mor- phia may be employed hypodermically, and chloroform by inha- lation. The strength may be sustained by rectal alimentation. 19 CONSTITUTIONAL DISEASES. RHEUMATIC FEVER. (Acute Articular Rheumatism, Inflammatory Rheumatism.) Definition.—An acute general disease, characterized by irregular fever, acid sweats, inflammation of the joints, and a marked tendency to involve the heart. Etiology.-—Heredity, temperate zone, occupations which necessitate exposure to cold and wet, early life (15—40), and one attack are predisposing factors. The disease is usually precipitated by sudden chilling of the body. The exciting cause is still unknown. Some regard it as a neurosis; others believe it to be infectious, and classify it with pneumonia, erysipelas, and similar diseases ; while still others attribute it to deranged metabolism. According to the last theory, the nitrogenous products, instead of being converted into urea, are transformed into lactic acid, uric acid, and other allied substances, and these deleterious agents are responsible for the symptoms. Pathology.—The ligaments and the synovial membrane and its fringes are congested and swollen. The svnovial sac is filled with a turbid fluid. The cartilages are roughened and occasionally ulcerated. Generally the process ends in resolu- tion ; sometimes the surrounding tissues become infiltrated with inflammatory lymph, and false anchylosis results ; rarely, suppuration of the joint follows. Sometimes small,subcuta- neous, fibrous nodules are found near the joints and large ten- dons. The blood shows an excess of fibrin and a considerable diminution of the red corpuscles. Fibrinous clots are often found in the heart and great bloodvessels. Secondary inflammations are frequently discovered, such as endocarditis, pericarditis, pleurisy, or pneumonia. (290) RHEUMATIC FEVER. 291 Symptoms.—The symptoms vary much in their severity. The disease usually begins abruptly, or more rarely follows such prodromes as malaise, chilliness, and sore throat. The large joints, especially the symmetrical ones, are usually affected ; they are slightly reddened, swollen, exquisitely painful, and tender to the touch. The inflammation shows a marked ten- dency not only to spread from joint to joint, but to disappear abruptly in one while it attacks another. The joints most commonly involved are the knees, elbows, ankles, and wrist ; but no joint is exempt. In severe cases the muscles are pain- ful, tender, and sometimes rigid. The fever rises rapidly to a moderate height (102°-103°), and is indefinite in its duration and extremely irregular in its course. Perspiration is often copious, has a peculiar sour smell and an acid reaction. The urine is scanty, high-colored, and on standing throws down an abundant sediment of urates and uric acid. The tongue is heavily coated ; the appetite is lost; and the bowels are con- stipated. The face is at first flushed, but as the disease advances it becomes decidedly pale from anaemia. The duration is indefinite, varying from a few days to several weeks. Complications.—Endocarditis (in 40 per cent, of all cases); pleurisy; pericarditis; pneumonia ; hyperpyrexia (106°-109°), which is often associated with maniacal delirium; chorea; iritis; meningitis; and certain cutaneous phenomena, such as urticaria, purpura, erythema nodosum, and subcutaneous fibrous nodules. Diagnosis. Septic Arthritis.—This may be recognized by its association with some other septic process and by the special tendency of the inflammation to end in suppuration, which is a verv rare termination of rheumatic fever. Gonorrhoeal Rheumatism.—This may be recognized by the history, by its obstinate character, and by its tendency to in- volve, not only large joints, but certain small joints which are rarely affected in rheumatic fever, like the sterno-clavicular, temporo-maxillary, and sacro-iliac. Rheumatoid Arthritis.—This begins in the small joints, attacks one after another, leads to permanent deformity, is not associated with fever and sweats, and shows no tendency to involve the heart. 292 CONSTITUTIONAL diseases. Gout—This occurs later in life, usually involves the great toe, and lacks high fever, acid sweats, and the tendency to heart complications. Prognosis.—Guarded. Most cases end in recovery ; some in chronic rheumatism; a very small number die of exhaustion, or some complication, such as hyperpyrexia. It is very prone to relapse and to recur. The most frequent complication is endocarditis ; this may never give rise to trouble, but frequently it leads to slow thickening or retrac- tion of the valves and to all the phenomena of chronic heart disease. Treatment.—Absolute rest in a room well-ventilated but free from draft; the patient should lie between blankets. The diet should consist mainly of milk and light broths ; meat should be interdicted. The free use of lemonade or mineral waters should be encouraged. Opium, phenacetin, or antipy- rin may be required to relieve the pain. Two remedies have considerable power in controlling the disease : salicyl compounds, and alkalies, like the salts of potas- sium ; these remedies may be given separately or in combina- tion. The salicylates relieve the pain, but do not prevent re- lapses or cardiac complications ; the alkalies apparently lessen the tendency to endocarditis. Salicylic acid (gr. x in capsules) or salicylate of sodium (gr. x-xx) may be given every two hours. Large doses may excite nausea and ringing in the ears. $. Sodii salicylat., gij ; Tinct. cardamom, comp., f3iv; Glycerin., L3ij ; Aqua? q. s. ad fgiv.—M. Sig.—A tablespoonful every two hours. The oil of gaultheria (nix every two hours) is another sali- cyl compound of decided value. If alkalies are employed, half a drachm of bicarbonate of potassium may be administered every two hours until the urine becomes distinctly alkaline. It is a good plan to combine alkalies with salicylates, thus :— RHEUMATIC FEVER. 293 I£ Sodii salicylat., gij ; Potass, bicarb., giij ; Glycerini, Tinct. cardamom, comp., aa f^ss ; Aqua? q. s. ad fgv.—M. Sig.—A tablespoonful every tw.o hours. . When there is much anaemia Basham's mixture (3j- directly into the muscle. The continued current is some- times useful. The introduction of needles, three or four inches long, deeply into the muscles (acupuncture) occasionally gives brilliant results. Internally, in acute cases, chloride of ammonium (gr. x four times daily) may prove efficient. In chronic cases, iodide of potassium, guaiac, colchicum, and the salts of lithium are the remedies usually employed. Gelsemium pushed to its physio- logical limit has been successful when other remedies have failed. Neural Manifestation.—Rheumatism appears to be a fre- quent cause of neuritis. Rheumatic Affections of Mucous Membranes.—It must be borne in mind that pharyngitis, tonsillitis, laryngitis, and bronchitis are sometimes dependent upon a rheumatic diathesis. Rheumatic Affections of Serous Membranes.—Endocar- ditis, pericarditis, pleuritis, iritis, and peritonitis may be excited by rheumatism. Cutaneous Manifestations.—Purpura, urticaria, and ery- thema nodosum are sometimes associated with rheumatism. GOUT. 297 GOUT. (Podagra.) Definition.—A general disease, characterized by varied constitutional disturbances, the presence of uric acid in the blood, the deposition of urate of soda in the fibrous structures of the joints, and recurrent attacks of acute arthritis. Etiology.—Middle and advanced life, male sex, heredity, a rich diet and the indulgence in liquors (especially malt liquors and strong wines), want of exercise, and working in lead are general predisposing factors. Pathology.—The blood contains uric acid, and the fibrous structures of the joint are the seat of a deposit of urate of soda. It is probable that from defective nerve-power the tissues generally are unable to perfect the metabolism of nitrogenous products into urea, and that uric acid and allied substances are thus formed. According to Ebstein, the uric acid excites a necrosis of the cartilages, whereupon the urates are crystallized out and deposited. The cartilages lose their pearly appearance and become lustreless and infiltrated with salts; similar opacities appear in the synovial membrane; later rounded masses of urate of soda (tophi), varying in size from a pea to a marble, accumulate in the tissues surrounding the joint and may ulcerate through the skin and be discharged. The fibrous structures become brit- tle and undergo destructive changes. The joint becomes irregularly enlarged, stiff, and finally anchylosed. The meta- tarso-phalangeal joint of the great toe, especially the right one, is first affected, but soon other small joints are involved. Gouty deposits are sometimes found along the tendons, beneath the peritoneum, in the perichondrium of the ear, and in the tarsal cartilages. . The kidneys are generally the seat of a chronic interstitial inflammation, and section frequently reveals a deposit of urates at the apices of the pyramids (gouty kidney). The arteries are sclerosed and the left side of the heart is hypertro- P Symptoms. Acute Gout.—Such prodromes as restlessness, insomnia, moroseness, and irritability of temper may precede the 298 CONSTITUTIONAL diseases. attack. The arthritic phenomena usually appear suddenly in the early morning hours and are characterized by pain and swell- ing in the ball of the great toe. The affected joint is exqui- sitely painful and tender, so that the slightest pressure cannot be borne; it is of a reddish-purple color; its surface is glazed; and the neighboring veins are full and distinct. The constitutional symptoms are restlessness, chilliness, moderate fever, perspiration, constipation, and scanty high- colored urine, which contains, during the paroxysm, less urates than in health. Towards daylight the symptoms abate and the patient falls to sleep. During the day he is comparatively comfortable, but there are severe exacerbations for several successive nights. At first the attacks may be a year apart, but as they multiply the interval grows less, until finally the patient is seldom entirely free from suffering. Retrocedent Gout.—This term is applied to a condition in which the arthritic phenomena suddenly subside and grave gastric, cardiac, or cerebral symptoms follow. Chronic Gout.—The joints are affected one by one, and become stiff, irregularly enlarged, and deformed. Chalk- stones, or tophi, sometimes ulcerate their way through the skin and are discharged. Similar deposits are frequently found along the tendons and in the helix of the ear. The constitutional symptoms vary much in severity and in char- acter. Nervous Phenomena.—Vertigo, headache, insomnia, irrita- bility of temper, and hypochondriasis. Gastro-intestinal Phenomena.—Perverted appetite, dyspepsia, constipation, and a tendency to hemorrhoids. Urinary Phenomena.—The urine is at first scanty, high- colored, and throws down an abundant brick-dust sediment; but ultimately interstitial nephritis develops and the urine becomes pale, copious, of a low specific gravity, and contains albumin and hyaline casts. Glycosuria is also frequently ob- served. Circulatory Phenomena.—High arterial tension, accentua- tion of the aortic second sound, and later, arterio-sclerosis and hypertrophy of the left ventricle. GOUT. 299 Complications and Sequelae.— Interstitial nephritis, arterio-sclerosis, hypertrophy of the heart, apoplexy, chronic bronchitis, and cutaneous eruptions, especially eczema. Diagnosis.—The symptoms of acute gout are so charac- teristic that an error in diagnosis is scarcely possible. Chronic gout may be mistaken for chronic rheumatism; but the former attacks especially the small joints; it begins in the great toe; the blood contains an excess of uric acid ; and the symptoms are not so much influenced by atmospheric changes as by diet. Prognosis.—As regards the acute form, the prognosis is good. The liability to arterial degeneration and to nephritis, and the difficulty in securing cooperation in carrying out the treatment render the prognosis of chronic gout rather unfavor- able. Treatment. The Acute Attack.—The best remedy is col- chicum ; ten to twenty drops of the wine well diluted should be given every two hours, and stopped as soon as the symptoms subside. Alkalies are valuable adjuncts, and the salts of potas- sium or of lithium may be given with the colchicum. Quinine is also useful; it may be given in doses of five grains thrice daily. The free use of water should be encouraged, and a water containing lithium, like the Buffalo lithia water, may be recommended. Constipation should be relieved by a full dose of blue mass or a saline draught. Opium may be required for the relief of the pain. The affected part should be elevated and wrapped in cotton-wool, or covered with warm fomenta- tions or with cloths soaked in lead-water and laudanum. The diet should be light and non-stimulating. Chronic Goid.—The diet must be restricted and carefully arranged for each patient. Light meats, fish, eggs, and oysters may be used in moderation ; sweet fruits should be avoided ; starches and sugars must be limited; and the use of liquors interdicted. The condition of the tongue, stomach, and urine will indicate the value of this or that dietary. Mineral waters are often serviceable, and Carlsbad, Vichy, and Buffalo lithia are among the best. Their utility will be enhanced by the addi- tion of a teaspoonful of some effervescing salt of lithium to each potation. A free secretion of the skin should be encour- 300 CONSTITUTIONAL DISEASES. aged by frequent bathing followed by friction. The bowels should be kept regular by salines or by the occasional use of a mercurial laxative. Graduated exercise holds a prominent place in the therapy of gout. When the digestive powers are particularly weak, mineral acids with strychnia will prove useful. General tonics are sometimes indicated. The special remedies are colchicum, lithium, and iodide of potassium. 1£ Vini sem. colchici, f^ss ; Potass, iodidi, gij ; Liq. potass., f^iss; Tr. zingiberis, fgij.—M. (Hodgson.) Sig.—A teaspoonful twice daily in warm water. Or small doses of colchicum may be given with— ]£. Lithii benzoat., 9ij ; Aq. cinnamom., fSijss.—M. (Jaccoud.) Sig.—A teaspoonful in a wineglass of water every four hours. The arthritic condition is best treated by careful massage and warm sulphur baths. RHEUMATOID ARTHRITIS. (Arthritis Deformans, Rheumatic Gout.) Definition.—A chronic affection of the joints characterized by destruction of the cartilages, new osseous formations, im- mobility, and deformity. Etiology.—Heredity; early adult life; female sex; con- tinued emotional disturbances, as anxiety and grief; enfeeble- ment of health from bad hygienic environment, prolonged lactation, and from frequent pregnancies, are the predisposing causes. Pathology.—Many look upon rheumatoid arthritis as a disease which is related both to gout and rheumatism. Others regard it as a neurosis and allied to the arthropathies which are met with in chronic affections of the spinal cord. The cells of the cartilages and of the synovial membrane proliferate and lead to villous or nodular outgrowths. The central portions of the cartilages ultimately wear away and leave the bones exposed. The heads of the bones become RHEUMATOID ARTHRITIS. 301 smooth and hard like ivory, and thickened from exostoses. The synovial membrane and periarticular tissues are likewise thickened and sometimes infiltrated with bony products. The surrounding muscles are generally atrophied. All joints are liable, to be affected. Symptoms.—It may be either acute or chronic, the latter being the more common form. In the acute form several joints are simultaneously involved ; they become swollen, pain- ful, and slightly reddened. There is moderate fever. The svmptoms soon subside, to reappear, however, at frequent intervals. In the chronic form, the hands, particularly the metacarpo- phalangeal joints, are usually first affected ; then the wrists, knees, toes, jaws, and spine. Symmetrical joints are usually attacked. The symptoms are : Swelling, pain, immobility, and deformity; the joints are stiff and creak when moved; later complete anchylosis develops; the muscles waste and con- tractures increase the deformity. In advanced cases the fingers are bent backward, often locked, and turned toward the ulnar side; the thighs are drawn up; the legs are adducted and flexed. The patient may be a helpless invalid for many years. Diagnosis. Gout—The circumstances under which gout develops; the history of an acute attack in the great toe; the presence of uric acid in the blood; the presence of urate of soda in the joints and in the cartilages of the ear will serve to distinguish the two diseases. Chronic Rheumatism.—Unlike chronic rheumatism, rheu- matoid arthritis begins in the small joints, passes from joint to joint, and leaves permanent deformity. Prognosis.—Unfavorable. Sometimes the disease is local and remains in one joint (mono-articular form). Generally several joints are affected, and while judicious and persistent treatment may retard the progress of the disease, a cure is rarely attainable. Treatment.—Good hygiene. Tonics like iron, arsenic, phosphorus, and cod-liver oil are useful. The most good is to be expected from local treatment, which consists of massage, electricity, steam baths, and inunctions of preparations con- taining iodine or mercury. 302 CONSTITUTIONAL DISEASES. RICKETS. (Rachitis.) Definition.—A constitutional disease of early childhood, characterized chiefly by defective nutrition of the osseous structures. Etiology.—Rickets is rarely congenital; it usually de- velops between the first and second years. Poverty, artificial feeding, and bad hygienic conditions are the predisposing causes. Pathology.—The most marked changes are observed in the long bones and ribs. The cartilaginous lamina between the epiphysis and the shaft are considerably thickened, and are spongy and irregular in outline; microscopic examination reveals an excessive proliferation of the cartilage-cells with scanty calcification. The periosteum is thickened and highly vascular, and when stripped off soft porous bone is exposed. The bones are soft, being extremely deficient in lime-salts; when ossification finally results the bones become heavy, large, and irregular in outline; these changes correspond to the clinical phenomena—bow-legs, knock-knees, spinal curvature, pigeon- breast, and square cranium. The liver and spleen are often considerably enlarged. Symptoms.—The early symptoms are: Restlessness and slight fever at night; free perspiration about the head; dif- fuse soreness and tenderness of the body; pallor; slight diar- rhoea ; enlargement of the liver and spleen ; delayed dentition and the eruption of badly-formed teeth. Skeletal Phenomena.—The head is large and more or less square in outline; careful palpation may detect soft areas. The sides of the thorax are flattened; the sternum is promi- nent ; nodules can be felt at the sternal ends of the ribs— " rachitic rosary" ; there may be a distinct transverse groove at the level of the ensiform cartilage; the spinal column is fre- quently curved antero-posteriorly or laterally ; the long bones are curved and prominent at their extremities. Complications.—Green-stick fractures, convulsions, laryn- gismus stridulus, paresis of the extremities, and acute pulmo- LITH^MIA. 303 nary diseases. In women the rachitic pelvis may seriously complicate labor. Prognosis.—Rachitis does not kill directly, but death is not uncommon from intercurrent disease. Under good hygienic conditions recovery, with more or less deformity, generally follows. Treatment.—The general nutrition must be improved by placing the child under the best hygienic conditions, ftggs, pure milk, prepared food, and broths should be recommended. Cod-liver oil is a valuable nutrient tonic. Iron is indicated for the anaemia. The lack of calcareous material in the bones should be supplied by the administration of phosphorus and lime-salts. !£. Syr. ferri iodid., f^iss ; Mist. ol. morrhuse et Lactophos. calcis, q. s. ad f^iij.—M. (Starr.) Sig.—From one-half to a teaspoonful three times a day. LITH^MIA. (Lithic-acid Diathesis, Uric-acid Diathesis, Latent Gout.) Definition.—A constitutional disease dependent upon mal- assi nidation of nitrogenous products and the formation of uric acid and allied substances instead of urea, and characterized by an excess of uric acid in the urine, and varied digestive, circulatory, and nervous phenomena. Etiology.—Gout with an acute arthritic expression is un- common in America, but latent gout, or lithaemia, is extremely common. Impaired digestion, insufficient exercise, mental strain, and over-eating are the usual causes. Symptoms. Gastro-intestinal Phenomena.—The tongue is generally coated and the breath heavy ; the appetite is variable, sometimes it is lost, at others it is inordinate ; acid eructations, " heartburn," and flatulence are frequent gastric symptoms; the bowels are usually constipated. Urinary Phenomena.—The urine is scanty, high-colored, of high specific gravity (1025 -1035), and on standing throws down an abundant brick-dust sediment. The solids render the urine irritating, so that dull aching in the loins and burn- 304 CONSTITUTIONAL DISEASES. ing in the penis after micturition are common symptoms. A trace of sugar is sometimes detected on chemical examination. The urine often stains the clothes red. Circulatory Phenomena.—High arterial tension, accentua' tion of the aortic second sound, and a tendency to atheroma. Nervous Phenomena.—Headache, vertigo, disturbed sleep, tinnitus auriuni, depression of spirits, failure of memory, loss of energy, irritability, and neuralgic pain in various parts of the body. Sequelae. — Arterial degeneration, interstitial nephritis, hepatic cirrhosis, gastritis, renal or vesical calculi. Diagnosis.—This rests on the general symptoms and the analysis of the urine. Prognosis. — Favorable under prolonged and judicious treatment. Treatment.—Special attention must be given to the diet. It is a mistake to cut off all nitrogenous foods, for often the chief difficulty is in digesting the starches and sugars. Light meats, green vegetables, eggs, and oysters are admissible. The use of fats, heavy meats, sweets, starches, and alcoholic beverages must be restricted. Next to diet, regular exercise is the most important therapeutic measure; the patient must eat less or burn up more material, and the chief stimulant of tissue-metab- olism is exercise. A change of scene may effect brilliant results. Frequent bathing with salt water followed by friction is a valuable adjunct. When the gastric digestion is weak, mineral acids, strychnia, and pepsin are useful remedies. The salts of potassium and lithium are solvents of uric acid ; citrate of lithium (gr. xx), benzoate of lithium (gr. v), or citrate of potas- sium (gr. xx), may be given, well diluted, two hours after meals. Mineral-waters containing these salts may be recom- mended. The bowels should be kept regular by some simple laxative. DIABETES. (Diabetes Mellitus.) Definition.—A nutritional disease, characterized by the persistent presence of sugar in the urine, polyuria, and loss of flesh and strength. DIARETES. 305 Etiology.—Heredity, adult life, male sex, the Hebrew race, prolonged mental anxiety, and dietetic errors are pre- disposing causes. It rarely follows injury of the brain or cord. Pathology.—The lesions found after death have been so varied that the condition which is really responsible for diabetes is still undetermined. Puncture of the floor of the fourth ventricle will produce glycosuria, but the cases are rare in which lesions of this region have been found after death. In a notable number of cases the pancreas is the seat of cirrhosis and of fatty degeneration, but the relation of this condition to diabetes is still unknown. The liver is frequently enlarged and the seat of degeneration changes. The kidneys are enlarged and often reveal evidences of parenchymatous inflammation. According to one view, diabetes has its origin in the sympa- thetic nervous system, and results from a vaso-motor dilatation of the hepatic vessels causing a disturbance of the glycogenic function of the liver and the discharge of glucose in the urine. According to another theory, diabetes results from a func- tional or organic disease of those organs, particularly the pan- creas and liver, which are engaged in the assimilation of starches and sugars. Symptoms. Urinary Phenomena.—The urine is increased in quantity, the amount varying from three or four pints to as many gallons; its color is pale; its specific gravity ranges from 1015 to 1050; it has a sweetish taste and an aromatic odor. In summer it attracts flies and rapidly ferments. It may leave a whitish residue on the clothes. The percentage of glucose varies from a half per cent, to ten per cent.; the total amount excreted in twenty-four hours varies from a few ounces to a pound or more. General Phenomena.—There is loss of flesh and strength ; the temperature is normal or subnormal; the appetite is often inordinate, and the thirst unquenchable; the tongue is generally fissured and beefy-red ; the bowels are usually con- stipated. Cutaneous Phenomena,—The skin is harsh and dry, and fre- quently the seat of intense itching. Pruritus is especially ob- served at the genitalia, and this may be the first subjective symptom. 20 306 CONSTITUTIONAL DISEASES. Nervous Phenomena.— Headache, depression of spirits, diminished or lost patellar reflexes, impaired sexual power, dimness of vision, and neuralgia. The duration varies from a few weeks in the acute form to many years in the chronic form. C<>mplications.— Pulmonary tuberculosis, pneumonia, gangrene of the lung; defective vision from soft cataract, retinitis or atrophy of the optic nerve; cutaneous lesions, as boils, eczema, carbuncles, and gangrene; nephritis; and diabetic coma, or acetonoemia. This last condition is characterized by epigastric pain, dys-' pnoea, a sweetish odor of the breath, headache, delirium, stupor, and coma; it probably results from the presence of diacetic and oxybutyric acids in the blood. Diagnosis.—Care must be taken to distinguish simple gly- cosuria from diabetes. The former is recognized by being transient, and unassociated with the constitutional symptoms of diabetes. Pruritus and apparently causeless loss of flesh and strength should lead to a suspicion of diabetes. Prognosis.—The younger the patient, the stronger the hereditary tendency, the larger the amount of sugar excreted, the less the glycosuria can be controlled by diet alone, the graver the prognosis. On the other hand, when it occurs after middle life in association with a gouty diathesis, and the gly- cosuria is not pronounced, the prognosis for a long duration is comparatively favorable. Absolute cure is rarely attainable. Treatment. Dietetic Treatment.—Sugars and starches must be restricted. Since the patient's appetite is often inordi- nate, it is necessary to regulate the quantity and character of those foods which are recognized as admissible. The following foods may be included in the dietary :— Aninud Foods.—Meats of various kinds (except liver), game, light broths and soups, fish, and eggs. Vegetables.—Celery, lettuce, cauliflower, tomatoes, mush- rooms, string-beans, young onions, olives, water-cress, and spinach. Beverages.—Buttermilk, skim milk, sour wines (Rhine wines), carbonated waters, and coffee and tea without sugar. DIABETES. 307 Relishes.—Nuts of all kinds (except chestnuts), cream cheese, and pickles. Bread.—Bread made of gluten, bran flour, or almond flour. It should be borne in mind that all the gluten flours are rich in starch. Fruits.—Cranberries, sour cherries, limes, lemons, and red currants. Substitutes for Sugar.—Saccharin and glycerin. The following foods should be avoided: Liver, oysters, wheat bread, biscuits, pastry, potatoes, beets, carrots, peas, turnips, parsnips, sweet fruits, rice, barley, tapioca, corn-starch, corn-meal, chocolate, cocoa, syrups, preserves, and most liquors. Hygienic Treatment,—Graduated exercise ; frequent bathing with salt water followed by friction; the use of flannel underclothing; plenty of rest and sleep; and, if possible, a change of scene. Medicinal Treatment.—Tonics like iron, arsenic, strychnia, and cod-liver oil are often indicated. The special remedies are opium and its alkaloids—morphia and codeia—bromide of arsenic, ergot, antipyrin, salicylate of sodium, and alkalies. Opium is generally the most useful drug; it should be given in small doses gradually increased until the patient takes five or six grains daily. Codeia (gr. \ increased to gr. vj a day) has been thought preferable to either opium or morphia, but accor- ding to the clinical experiments of Bruce and Osier, morphia is much more reliable. The latter may be employed in doses of one-fourth of a grain three or four times daily. The bro- mide of arsenic is sometimes of decided value ; it may be given in the following solution :— I£ Liq. arsenici brom. (Clemens), fgj. Sig.—Two to five drops well diluted after meals. In gouty patients a course of Carlsbad water with salicylate of sodium (gr. iij-v thrice daily) and antipyrin (gr. v-x thrice daily) may be recommended, or:— ]£ Sodii salicylat., giij ; Liq. potass, arseuitis, f3j ; Glycerini, f^j; Aq. cinnamomi, ad f^iij.—M. (J. C. Wilson.) Sig. _A teaspoonful to a dessertspoonful thrice daily 308 CONSTITUTIONAL DISEASES. Diabetic coma is always fatal, but the intravenous injection of a copious solution (3 per cent.) of bicarbonate of sodium may give a few hours' respite, in which consciousness returns. DIABETES INSIPIDUS. Definition.—A chronic condition characterized by the excretion of large quantities of pale, limpid urine of low specific gravity and free from albumin and sugar. Etiology.—Diabetes insipidus must be distinguished from the simple polyuria observed in chronic renal disease, in cer- tain diseases of the brain, and in some cases of hysteria. Diabetes insipidus sometimes develops without obvious cause. It is more common in the young, and more males are attacked than females. It is occasionally hereditary. It has been induced by injury and by certain diseases of the brain. Profound emotional disturbance has excited it. Syphilis, overwork, and the free use of cold water when the body has been overheated, are reputed causes. Pathology.—Little is known of the pathology. The kidneys are frequently enlarged and congested, and the ureters dilated. The theory which is generally accepted as accounting for the polyuria, is that it is due to a vaso-motor paresis of the renal vessels, which permits a free transudation of liquid. Symptoms.—The disease may begin insidiously or abruptly; the latter is the rule. The urine: The quantity is increased, often as much as eight or ten quarts being excreted in the twenty-four hours ; it is pale, and resembles water; it has a specific gravity of 1002-1005. The total amount of solids is not diminished. Albumin and sugar are generally absent, though there may be a trace of the latter. General Symptoms.—Insatiable thirst; good appetite; a harsh, dry skin ; a dry tongue; constipation ; mental apathy ; and emaciation. Duration.—AVhen unassociated with organic disease the duration may be indefinite. Complications.—These are much less common than in diabetes mellitus. Cataract, pruritus, boils, and tuberculosis have been observed. DIABETES insipidus. 309 Diagnosis. Diabetes Mellitus.-—The low specific gravity of the urine and the absence of sugar will serve to distinguish diabetes insipidus from diabetes mellitus. Interstitial Nephritis.—The presence of albumin, hyaline casts, high arterial tension, accentuation of the aortic second sound, and the cardiac hypertrophy will indicate nephritis. Symptomatic Polyuria.—The history and a careful physical examination will usually prevent an error in diagnosis. Prognosis.—Usually unfavorable. A permanent cure is sometimes effected. Death results from exhaustion, or more frequently, from some intercurrent disease. Treatment.—The hygienic treatment suggested for diabetes mellitus is applicable in this disease. No benefit is derived from cutting off the amount of water drunk. Lemonade and other acid drinks may serve to lessen the amount of liquid consumed. The remedies recommended are ergot, strychnia, opium, valerian, and nitric acid. Galvanism—one pole applied to the neck and the other to the loins—has given good results. When syphilis is suspected, the mercurials and iodides may be administered freely with good hopes of a successful issue. I£ Pulv. opii, gr. iv; Acid, gallici, gij.— M. (H. C. Wood.) Ft. in chart. No. xii. Sig.—One, three or four times daily. DISEASES OF THE NERVOUS SYSTEM. DISTURBANCES OF MOTION. These consist, for the most part, of loss of power, or para- lysis, and manifestation of motor excitation, such as convul- sions, choreiform movements, and tremors. Paralysis. The paralysis may be irregularly distributed, or it may in- volve a single member, when it is termed monoplegia ; a lateral half of the body, when it is termed hemiplegia ; or the body from the waist down, when it is termed paraplegia. Irregular paralysis may result from :— 1. Dissemjnated lesions in the motor areas of the brain, which are commonly syphilitic. 2. Lesions in the basal ganglia—pons, crura cerebri, medulla, when it is often associated with headache, .vomiting, vertigo, and optic neuritis. 3. Acute poliomyelitis. This develops abruptly ; it occurs in young children ; and it is followed by rapid improvement in some muscles and permanent atrophy and paralysis in others. 4. Chronic poliomyelitis. This develops in middle life; begins in the small muscles of the hand; is associated with atrophy ; and progresses very slowly. 5. Idiopathic muscular atrophy. This commonly develops during adolescence; involves the muscles of the arm, shoulder, (310) DISTURBANCES OF MOTION. 311 buttocks, and thigh; is associated with atrophy; and can be frequently traced to heredity. 6. Pseudo-muscular hypertrophy. This develops in child- ren ; is associated with enlargement of the affected muscles; and can be frequently traced to heredity. 7. Multiple neuritis. This is recognized by the history, pain, disturbances of sensation, and tenderness over the nerve- trunks. 8. Syringo-myelia. This is rare; develops during ado- lescence ; and is recognized by pains, atrophy of the affected muscles, a spastic condition of the paralyzed members, and a loss of thermic and painful sensations, while tactile sensation is retained. Monoplegia may result from :— 1. A focal lesion in the cortical area of the brain. This may be recognized by the history, the absence of wasting, of sensory disturbances, and of the reactions of degeneration. 2. A lesion of the peripheral nerve, from traumatism, neu- ritis, or the pressure of a tumor. Brachial monoplegia fre- quently results from the pressure of the head on the arm during sleep. Monoplegia of peripheral origin is recognized by the history, the wasting, the sensory disturbances, and the presence of reactions of degeneration. 3. Hysteria. This may be recognized by the history, sex, and temperament; the paroxysmal character of the paralysis; the disturbances of sensation; and contractures without atrophy or electrical disturbances. Facial monoplegia may result from a small lesion in the facial centre of the cortex or in the medulla; or from involve- ment of the nerve in the canal of the temporal bone; or after its exit from the stylo-mastoid foramen. Facial diplegia (double facial paralysis) generally results from a lesion at the base of the brain. Hemiplegia may result from :— ]. A diffuse lesion of the motor cortex. The paralysis is on the opposite side of the body and is unassociated with f) w ?p^t nGSi£i« 2. A lesion of the internal capsule or the adjacent ganglia (corpus striatum and optic thalamus). This is the most 312 DISEASES OF THE NERVOUS SYSTEM. common seat of hemorrhage; the paralysis is on the opposite side of the body and is unassociated with anaesthesia. 3. A lesion of the crus cerebri. This frequently produces hemiplegia and hemianesthesia on the opposite side, and par- alysis of the oculo-raotor nerve on the side of the lesion, indi- cated by dilated pupil, strabismus, and ptosis. 4. A* lesion of the pons. This frequently produces hemi- plegia and hemianaesthesia on the opposite side, and facial paralysis on the side of the lesion. 5. A lesion in the medulla. This is rare, and is associated with paralysis of the cranial nerves, difficult articulation, car- diac and respiratory disturbances, and vomiting. 6. A unilateral lesion high in the cord (very rare). This produces a spastic paralysis on the side affected, and hemianaes- thesia on the opposite side (" Brown-Sequard's paralysis"). 7. Hysteria. This may be recognized by the history, sex, and temperament; by being frequently paroxysmal; by its association with sensory disturbances ; by the absence of wast- ing and of abnormal electrical reactions ; and by the escape of the facial muscles. Paraplegia may result from :— 1. Hemorrhage into the cord at the dorsal region. The paralysis develops abruptly, and is associated with complete anaesthesia and involvement of the bladder and rectum. 2. Hemorrhage into the membranes of the cord. The par- alysis develops rapidly, but more slowly than the preceding; is associated with intense tearing pains and incomplete anaes- thesia. 3. Some forms of multiple neuritis. This is recognized by the pains, the disturbances of sensation, the tenderness over the nerve-trunks, and the absence of "girdle pain" and sphincter involvement. 4. Fracture of the vertebrae. 5. Acute myelitis. The paralysis develops in the course of a few days, and is associated with anaesthesia, bedsores, involve- ment of the bladder and rectum, loss of reflexes, and wasting of the muscles. 6. Landry's disease (acute ascending paralysis). This de- velops in the course of a few days, and is unassociated with DISTURBANCES OF MOTION. 313 anaesthesia, wasting of the muscles, bedsores, or sphincter in- volvement. 7. Chronic myelitis. This develops over several years, and is associated with numbness and tingling, increased reflexes, involvement of the bladder and rectum, and anaesthesia. 8. Compression of the cord from morbid growths, aneurism, or spinal caries. This may be recognized by the history, the symptoms of the primary disease, the anaesthesia or hyper- esthesia, and the intense pains radiating along the line of the spinal nerves. 9. Lateral sclerosis. This develops slowly and is associated with a spastic condition of the muscles and with increased reflexes, and lacks sensory disturbances. 10. Injury of the brain in delivery (spastic paraplegia of infants). The symptoms resemble lateral sclerosis, and are often associated with imbecility or idiocy. 11. Hysteria. This may be recognized by the history, sex, and temperament; by being frequently paroxysmal; and by the absence of wasting and of abnormal electrical reactions. 12. Caisson disease (divers' paralysis). The history will establish the diagnosis. Convulsions. A convulsion is a condition in which there are excessive muscular contractions, continued or intermittent, dependent upon an involuntary discharge of motor impulses from the nerve-centres. Intermittent contractions are termed clonic ; continued con- tractions, tonic. Convulsions may be general or local. The term spasm is sometimes applied to the latter. There is no real line of distinction between convulsions, choreiform movements, and tremors. Varieties of Convulsions.—Three varieties are frequently made: (1) Epileptiform ; (2) tetanic; (3) hysteroidal. Epileptiform Convulsions.—In this form there is uncon- sciousness, and the movements are for the most part clonic. Epileptiform convulsions may result from :— 314 DISEASES OF THE NERVOUS SYSTEM. 1. Idiopathic epilepsy. This. condition usually develops before puberty, and the convulsions are general and are unassociated with any definite cause. 2. Organic brain disease. In this condition there may be a history of syphilis or of injury; the convulsions may be local, or begin as such and become general; and there may be concomitant symptoms of cerebral disease. 3. Toxic agents in the blood. Alcoholism, the infectious fevers, and uraemia are frequently associated with convulsions. 4. Reflex irritation. Such convulsions are usually observed in young children, and result from gastric irritation, an ad- herent prepuce, intestinal parasites, or teething. Convulsive seizures sometimes result from the injection of substances into the pleural sac for the cure of hydrothorax. 5. Cerebral anaemia. Such convulsions are seen after pro- fuse hemorrhage, in fatty heart, and in poisoning from cardiac paralyzants like aconite and veratrum viride. Eclampsia. This term is applied to designate accidental convulsions, such as the convulsions of childhood resulting from reflex irritation, and the convulsions of pregnancy or the puerperium, resulting from toxic materials retained in the blood. Tetanic Convulsions.—In this form the discharges emanate from the spinal cord, and are not associated with a loss of con- sciousness. Tetanic convulsions may result from :— 1. Tetanus. This is recognized by the history of a wound, the tonic character of the convulsions, the early involvement of the jaw, and the absence of fever. 2. Spinal meningitis. This is recognized by exquisite pain in the back, fever, and late involvement of the jaw. 3. Strychnia-poisoning. This is recognized by the history, the intermittent character of the convulsions, the absence of fever, and the escape of the muscles of the jaw until very late. 4. Tetany. In this condition the extremities are chiefly in- volved; the convulsions are intermittent, and can be produced by pressure on the nerves and arteries of the affected limbs. Hysteroidal Convulsions.—These are manifestations of hys- teria, and in them consciousness is only partially or apparently lost. They are not preceded by an aura, but sometimes by a DISTURBANCES OF MOTION. 315 sensation of a ball in the throat—the "globus hystericus ;" the eyes are partially closed; the face expresses some emotion; the tongue is not bitten ; the movements are tonic, or if clonic, appear wilful; the paroxysm is of long duration ; and the patient frequently weeps or laughs. Local Convulsions or Spasm.—Spasm of the face may result from a (1) cortical lesion in the inferior portion of the ascend- ing frontal convolution ; (2) from tic convulsif—a condition occurring in young children, affecting the facial and neighbor- ing muscles, and associated with mimicry, a tendency to use profane language, and various mental disturbances; (3) from habit (habit-chorea) ; and sometimes from (4) tic doxdoureux— neuralgia of the fifth nerve. Temporary spasms of one arm or one leg are -usually mani- festations of Jacksonian epilepsy (focal epilepsy), but they sometimes result from hysteria. Spasm of the hand developing when the member is put to use may result from writers' cramp, Thomsen's disease, or hysteria. Spasm of the cervical muscles (wry-neck, torticollis) may result from congenital shortening of the sterno-mastoid, myal- gia, hysteria, caries of the vertebrae, or the irritation of en- larged cervical glands. Spasms of the larynx, oesophagus, and diaphragm (hiccough) have already been discussed. Saltatory Spasm.—This term is employed to designate a condition allied to hysteria, in which a violent spasm seizes the muscles of the leg as soon as the feet touch the ground, and as a result the patient is thrown violently into the air. Salaam Convulsions.—These consist of violent paroxysmal bobbing movements of the head or trunk, and may be asso- ciated with hysteria, chorea, or rarely, organic brain disease. Choreiform Movements. These are coarse, jerky, irregular, involuntary movements which more or less simulate purposive movements. They may result from :— 1. Idiopathic chorea (St. Vitus's dance). This disease is 316 DISEASES OF THE NERVOUS SYSTEM. seen in children ; is usually mild; runs a course of several weeks; and is prone to be followed by endocarditis. 2. Chorea insaniens. A grave disease occurring in adults, especially pregnant women, and characterized by violent move- ments, delirium, and fever. 3. Huntingdon's chorea (chronic chorea). An affection oc- curring in adult life, generally hereditary, and characterized by irregular movements, disturbance of speech, and increasing dementia. 4. Organic brain disease. Choreiform movements are fre- quently observed in cerebral palsies of children; they may also develop on one side of the body before an attack of apo- plexy (pre-hemiplegic chorea), or in the paralyzed members after the hemorrhage (post-hemiplegic chorea). 5. Peripheral irritation. Choreiform movements sometimes develop in pregnancy, and are occasionally noted in stumps after amputation. 6. Habit. Children frequently acquire, through constant repetition or mimicry, choreiform movements which may last indefinitely. 7. Hysteria. The marked rhythmical character of the movements and the history will aid in the recognition of hysterical chorea. 8. Disseminated cerebro-spinal sclerosis. This disease usu- ally induces tremors, but not uncommonly the movements are choreiform. The increased reflexes, the nystagmus, the loss of power, the spastic gait, and the impairment of intellect will aid in its recognition. 9. Paramyoclonus multiplex. A very rare disease, of un- known origin, characterized by continued or paroxysmal choreiform movements which develop or increase under ex- citement or movement. Athetosis. This term was employed by Hammond to designate certain movements occurring chiefly in the hands and feet, and charac- terized by slow twisting, intertwining, separation, and exten- sion of the fingers and toes. Athetosis is frequently observed DISTURBANCES OF MOTION. 317 in the cerebral pdsies of children, and it occasionally occurs in adults as a result of lesions in the basal ganglia. Tremors. A tremor is a fine vibratory movement due to the alternate contraction and relaxation of antagonistic muscles. Tremors are observed in the following conditions :— 1. They may exist from birth unassociated with other symptoms. " 2. They may depend upon a lowered tone of the nervous system, being frequently observed in neurasthenia and in the convalescence from acute disease. 3. They may be toxic, resulting from alcoholism or mer- curial poisoning. 4. They may be due to old age. 5. They are frequently a symptom of organic disease of the brain and cord ; as such, they are met with in paretic dementia, and especially in disseminated sclerosis. 6. They may be the chief symptom in paralysis agitans. 7. They may be hysterical. The Gait. The Ataxic Gait.—In locomotor ataxia the patient raises the foot high, throws it forward, and brings it down suddenly, so that the whole sole comes in contact with the floor at once. Spastic Gait.—In spastic paraplegia the movements are stiff, the knees come together, the leg drags behind, and the toe catches the ground., # Festination.—This term is applied to the gait of advanced paralysis agitans; in walking, the body inclines more and more forward, and the steps grow faster and faster until the patient falls, straightens himself by an effort, or finds support in some neighboring object. # . Steppage Gait___In chronic multiple neuritis the patient raises the foot high, turns the toe up, and brings the heel down The Gait of Pseudo-muscular Hypertrophy.—The feet are wide apart, the belly protrudes, and the movements are clumsy and waddling. 318 DISEASES OF THE NERVOUS SYSTEM. Tituhation.—This term is applied to the peculiar gait ob- served in lesions of the cerebellum. It resembles the gait of locomotor ataxia, but is much more staggering. It is not de- pendent upon loss of coordination, for in lying down the patient can perfectly control his movements. The absence of the Argyll-Pobertson pupil, of sharp pains, and of diminished reflexes will separate cerebellar disease from locomotor ataxia. The Reflexes. The " tendon reflexes" were formerly thought to be a pure reflex phenomenon, but the tendency at present is to regard them as resulting from the contraction of the muscle itself. But that the muscle shall contract, it must receive certain impulses from the cord, which keep it in a condition of irrita- bility. It follows, therefore, that reflexes are dependent upon the condition of the cord as well as of the muscles. The Knee-jerk, or Patellar Tendon Reflex.—This is ob- tained by tapping the quadriceps tendon between its insertion and the patella while the leg is crossed over its fellow. The knee-jerk is increased in the following conditions :— 1. Frequently in organic disease of the brain, probably from irritation of the cord. 2. In lesion pf the cord above the lumbar enlargement, probably from cutting off the influence of the reflex inhibiting centre in the upper part of the cord. 3. In disseminated cerebro-spinal sclerosis and in lateral sclerosis. 4. In irritability of the cord, as in mania, hysteria, strych- nia-poisoning, and spinal meningitis. The knee-jerk is diminished or absent in the following con- ditions :— 1. Degeneration of the muscle, as in pseudo-muscular hy- pertrophy. 2. In lesions of the nerves which cut off the impulse from the cord—as neuritis. 3. In lesion of the posterior columns of the cord, as in loco- motor ataxia. 4. In poliomyelitis, acute and chronic (the anterior gray matter is part of the reflex centre). DISTURBANCES OF MOTION. 319 5. In advanced myelitis, when the cord is sufficiently injured. 6. In exhaustion of the spinal centres, as after prolonged laborious work. 7. In poisoning from drugs which depress the cord, as anti- mony, chloral, etc. 8. In certain general diseases, as diabetes and diphtheria. Ankle-clonus.—This consists of vibratory movements obtained by supporting the tendo-Achilles with one hand, while the foot is strongly flexed with the other. It can rarely be obtained in health, but is often marked in hysteria and in lateral sclerosis. Arm-jerk.—This is obtained by striking the biceps tendon at the elbow, or the triceps tendon above the olecranon. Jaw-jerk.—This is obtained by tapping the jaw while the mouth is partially open. The Superficial Reflexes.—These are probably true reflexes, and consist in muscular contractions resulting from irritation of the skin. The following table is based upon the description given by Ross in his Handbook of Nervous Diseases :— The Reflex. Plantar . Gluteal . Cremasteric Abdominal . . Epigastric . . Erector Spinal Scapdlar . . Palmar . Produced by Tickling the sole of the foot. Stimulating the skin over the buttock. Stimulating the skin on the inner side of the thigh. Stroking the skin on the side of the abdomen. Stimulating the sides of the chest in the fifth and sixth intercostal spaces. Irritation from the angle of the scapula to, the iliac crest. Irritation of the scapular region. Tickling the palm. Depends upon Integrity of The lower end of the cord (conus medullaris). Loops through the fourth and fifth lumbar nerves. First and second pairs of lumbar nerves. The arcs from the eighth to the twelfth dorsal nerves. The arcs from the fourth to the seventh pairs of dorsal nerves. The arcs in the dorsal region of the cord. The arcs of the upper two or three dorsal and the lower two or three cervi- cal nerves. The arcs through the greater part of the cervi- cal enlargement. 320 DISEASES OF THE NERVOUS SYSTEM. The chief cranial reflexes are contraction of the palatal muscles by irritation of the fauces ; sneezing, by irritation of the nares; cough, by irritation of the larynx ; closure of the eyelids, by irritation of the conjunctiva; and contraction of the iris, by light. Paradoxical Contraction. (Westphal.)—This is a peculiar phenomenon consisting of a tetanic contraction of the tibialis anticus, lasting for several minutes, and induced by forcibly flexing the foot on the leg. Its cause is unknown. It has been observed in early locomotor ataxia, multiple sclerosis, hysteria, and paralysis agitans. DISTURBANCES OF SENSATION. These consist chiefly in a loss of sensation—anaesthesia; in- creased sensation—hyperesthesia ; certain abnormal sensations —paroesthesia ; and subjective painful sensations—neuralgia. Anaesthesia. Ordinary cutaneous sensibility may be tested by the prick- of a pin, by a pinch, or by the faradic current. Anaesthesia results from interruption of the sensory tract in the nerves, as by neuritis; from interruption of the sensory tract in the cord or brain ; from organic disease of the sensory area of the brain; from the action of toxic substances on the nerves or centres; from certain functional conditions like hysteria ; and from reflex irritation. Hcmianoesthesia.—A loss of sensation on a lateral half of the body. It may result from :— 1. Hysteria. This is often unassociated with paralysis of motion, and may be recognized by the history, sex, and tem- perament of the patient; by the paroxysmal character of the anaesthesia; and by exclusion of other causes. 2. A unilateral lesion high in the cord. This is very rare, and may be recognized by being associated with hemiplegia on the opposite side. 3. A lesion of the medulla (very rare). The hemianaes- thesia is usually associated with hemiplegia, paralysis of the DISTURBANCES OF SENSATION. 321 cranial nerves, difficult swallowing, and cardiac and respiratory disturbances. 4. A lesion in the pons. The hemianesthesia is often associated with hemiplegia on the same side, and facial palsy on the opposite side. 5. A lesion in the crus, or peduncle. The hemianesthesia is often associated with hemiplegia on the same side and paralysis of the oculomotor nerve on the opposite side. 6. A lesion of the posterior limb of the internal capsule, or of the optic thalamus pressing on the capsule. 7. A lesion of the occipital cortex. Monancesthesia.—A loss of sensation in one member. It may result from hysteria, from a focal lesion of the occipital cortex, or from a lesion of the nerves supplying the member. Paranaesthesia.—A loss of sensation in all parts below the waist. It may result from hysteria, organic diseases of the cord, neuritis of the lower extremities, or reflex irritation. Thermo-anoesthesia.—Insensibility to heat or cold occurring as an independent condition. It is sometimes observed in hysteria and syringo-myelia. Analgesia.—Insensibility to pain. It is sometimes observed in hysteria, in syringo-myelia, and in lesions of the spinal cord. Retardation of Sensations.—This is frequently observed in all forms of anaesthesia, but especially in the anaesthesia of loco- motor ataxia. The Sense of Pressure.—This is tested by blocks of wood loaded with lead, of different weights, the arm being held on a table so as to exclude the muscular sense. Partial paralysis of this sense is often noted in locomotor ataxia. The Sense of Space.—The distance at which two points of contact can be recognized as two points. Normally the dis- tance varies in different parts and in different individuals. On the cheek it is 11-15 millimeters. On the forehead, 22 millimeters. On the forearm, 40 millimeters. On the chest, 45 millimeters. On the thigh, 77 millimeters. On the leg, 40 millimeters. 322 DISEASES OF THE NERVOUS SYSTEM. On the palm of the hand, 8-12 millimeters. On the back of the hand, 31 millimeters. Hyperesthesia is increased sensibility to external impres- sions. It is commonly observed in hysteria, especially in connection with the joints, breasts, genitalia, and spine. It is also ob- served in neurasthenia, and in beginning inflammation of the nerves and of the cerebro-spinal meninges. Paresthesia.—This term is used to indicate certain disa- greeable subjective phenomena, such as numbness, tingling, itching, creeping, and " pins and needles." Paresthesia is observed in many conditions, as hysteria, spinal sclerosis, neurasthenia, and injury or inflammation of the nerves. Girdle Sensation.—The sense of having a girdle or tight band around the trunk. It is frequently observed in spinal sclerosis. Neuralgia.—This consists of paroxysms of severe pain radiating along the line of the nerve-trunks. The pain is re- lieved by pressure, but there are tender spots (points doulou- reux) where the nerve makes its exit from bony canals or muscular coverings. Lightning-pains.—This term is applied to the sharp lancinat- ing pains observed in locomotor ataxia. They usually occur in the extremities, and may be mistaken for rheumatism. Causalgia.—This term has been applied by S. AYeir Mit- chell to an intensely burning sensation generally observed in " glossy skin." Muscular Sensibility.—This term is applied to the appreci- ation of the sensation which attends the contraction of a muscle under the faradic current. Muscular Sense.—This is the sense by which weight, mus- cular effort, and position are determined. It is often defective in hysteria, locomotor ataxia, and in many forms of paralysis. DISTURBANCES OF NUTRITION. These consist in atrophy of the muscles, changes in electro- muscular contractility, tissue-metamorphoses, and in certain abnormalities of the appendages. DISTURBANCES OF NUTRITION. 323 Muscular Atrophy. Atrophy, or wasting of the muscles results from :— 1. Inactivity. Cerebral palsies may thus be associated with slow wasting. 2. Lesions of the trophic cells in the anterior gray horns of the cord, as in acute and chronic poliomyelitis. 3. Lesions of the nerves, such as neuritis or traumatism. 4. Certain diseases of the muscles themselves, as idiopathic muscular atrophy. The atrophy which attends chronic affections of the joints probably results from neuritis. The Reaction of Degeneration. In muscular paralysis there may be simply diminished elec- trical excitability. This is termed a quantitative change. In some cases, however, there is a complete reversal of the normal phenomena. This is termed a qualitative change, or the reaction of degeneration. The reactions of degeneration are obtained with the galvanic current applied to muscles in the advanced stage of degeneration. The subjoined table, setting forth the electro-muscular phenomena in health and disease, follows closely the description of H. C. Wood :— The anode—the positive pole ; the cathode—the negative pole. When a galvanic current of moderate strength is em- ployed, and the cathode is placed over the normal muscle, a strong contraction occurs when the circuit is closed ; when the anode is placed over the muscle the contraction is much less ; in neither case is there any contraction when the current is broken. When a strong current is used contractions are pro- duced, and the anodal contraction is greater than the cathodal. The reaction of degeneration consists in a reversal of these phenomena. 324 DISEASES OF THE NERVOUS SYSTEM. Normal muscle. A nodal closing" contraction (AnClC) is less than the catho- dal closing contraction (CaCIC). Auodal opening contraction (AnOC) is greater than the cathodal opening contraction (CaOC). Muscle in first stage of degeneration. Anodal closing contraction (AnClC) equals the cathodal closing contraction (CaCIC). Anodal opening contraction (AnOC) equals the cathodal opening contraction (CaOC). Muscle in advanced stage of degeneration. Anodal closing contraction (AnClC) is greater than the cathodal closing contraction (CaCIC). Anodal opening contraction (AnOC) is less than the cathodal opening contraction (CaOC). The reactions of degeneration are observed in diseases which destroy the trophic cells in the anterior gray horns of the cord or which cut off their influence. Thus they are observed in acute and advanced chronic poliomyelitis, in acute central mye- litis, in severe neuritis, and after section or compression of the nerves. Arthropathies. An arthropathy is a degenerative affection of the joints, characterized by marked swelling due to effusion, erosion of the cartilages, relaxation and calcification of the ligaments, and atrophy of the heads of the bones. Arthropathies are observed especially in locomotor ataxia and in cerebral hemiplegia. Some regard the joint-phenomena of rheumatoid arthritis as belonging to this class. Myxcedema. Myxoedema consists of an overgrowth of mucoid tissue in the subcutaneous tissues ; it occurs as an idiopathic affection ; DISTURBANCES OF CONSCIOUSNESS. 325 sometimes after the removal of the thyroid gland; and as a symptom of cretinism. Ulceration Resulting from Perverted Nutrition. Acute Decubitus.—This term is applied to ulcers appearing in a few hours or days, on parts subjected to pressure, after the occurrence of a severe cerebral or spinal lesion. Chronic Decubitus.—This term is applied to the ulcers which ultimately appear on parts subjected to pressure in the course of chronic spinal affections. Perforating Ulcer of the Foot.—This term is applied to .an undermining ulcer of the foot most commonly observed in locomotor ataxia. It frequently penetrates the deep structures and involves the bones. Symmetrical Gangrene (Reynaud's Disease).—This is a gan- grenous affection involving the fingers, toes, tip of the nose, or ears. It arises spontaneously, and is probably due to a vaso-motor spasm. Trophic Affections of the Skin. — Herpes, scleroderma, vitiligo, chloasma, and the "glossy skin" following injuries of the nerve-trunks, are illustrations of this class of trophic phenomena. Trophic Affections of the Hair and Wails.—After injury of the nerves and in neuritis the nails often become dry, brittle, and cracked. Under similar conditions there may be a loss of hair, an overgrowth of hair, or a change in the color of the hair. DISTURBANCES OF CONSCIOUSNESS. Coma. Coma is a condition of unconsciousness from which the patient cannot be aroused. Temporary unconsciousness, due to anaemia of the brain, is termed syncope, which may be recognized by the extreme pallor, weak pulse, and feeble heart-sounds. 326 DISEASES OF THE NERVOUS SYSTEM. 1. Coma may result from traumatism. This can only be recognized by the history or the local evidence of injury. 2. Organic Disease of the Brain.—The most common cause under this head is apoplexy, which may be recognized by the history, the age, the condition of the arteries, and by evidences of paralysis, such as unnatural relaxation or rigidity on one side of the body, conjugate deviation of the eyes, or a higher temperature in one axilla. 3. Epilepsy.—The coma of epilepsy is usually of short dura- tion. It may be recognized by the history, by the bloody saliva, by the presence of scars on the tongue from previous attacks, and by the exclusion of other causes. 4. Thermic Fever (Sunstroke).—The temperature of the day or of the room in which the patient is found, the extremely high body-temperature, and the absence of other causes will usually prevent an error in diagnosis. 5. Certain Drugs.—Under this head come alcoholism and opium-poisoning. In alcoholism the patient can generally be aroused by shouting in the ear, there is the odor on the breath, and there is an absence of other cause. In opium-poisoning the pupils are small, the respirations are slow, the temperature is normal or subnormal; there may be the odor of laudanum on the breath. The diagnosis will be aided by the exclusion of other causes. 6. Uraemia.—In this condition there is a urinous odor on the breath ; the aortic second sound is accentuated ; the urine contains albumin ; the temperature may be above or below normal; the pupils are usually small, and there is no evidence of other cause. 7.. The Infectious Fevers.-—-The history is sufficient to make the diagnosis. Pernicious malarial fever may produce sudden coma, and in this condition the examination of the blood would render a diagnosis possible. 8. Hysteria.—The history, age, and sex of the patient, and the absence of other cause will usually prevent an error in diagnosis. DISTURBANCES OF THE SPECIAL SENSES. 327 Trance. In this condition the patient lies for several days apparently dead, the pulse aud respiration being imperceptible. It is usually a manifestation of hysteria. Somnambulism. A dreamlike state, in which the patient performs auto- matically various feats—such as walking, singing, writing, etc. Mild forms, such as talking and walking in sleep, may occur in health. More marked manifestations occur in hysteria and in hypnotism. Ecstasy. A condition of apparent insensibility in which the mind is wholly absorbed with a fancy or delusion. It occurs in the hysterical. The dancing mania of the middle ages is a good illustration of it. Catalepsy. This term is applied to attacks characterized by a peculiar stiffness of the muscles, and when this is overcome by force the limbs can be placed in unnatural positions, which they retain for a long time. There may or may not be a loss of consciousness and sensation. It is observed in hysteria, hyp- notism, in some cases of epilepsy, in some organic diseases of the brain, and in certain forms of insanity—notably katatonia. DISTURBANCES OF THE SPECIAL SENSES. The Eye. Myosis.—Contraction of the pupil occurs in many condi- tions, notably in locomotor ataxia, paretic dementia, some cases of disseminated sclerosis, old age, uraemia, and opium- poisoning. Mydriasis.—Dilatation of the pupil is also observed in manv conditions, notably in atrophy of the optic nerve, 328 DISEASES OF THE NERVOUS SYSTEM. paralysis of the third nerve, collapse, severe pain, epileptic seizures, hysterical attacks, belladonna-poisoning, and in some cases of locomotor ataxia and paretic dementia. Inequality of the Pupils.—This may occur in health, in ocular defects, in organic brain disease, in paretic dementia, in locomtor ataxia, and in unilateral paralysis of the oculo- motor nerve. Argyll-Robertson Pupil.—This is one which fails to respond to light, but still accommodates for distance. It is noted espe- cially in locomotor ataxia and paretic dementia. Conjugate Deviation of the Eyes.—This term is applied to the rotation of both eyes away from the median line. It is noted especially in apoplexy and in convulsions of organic brain disease. Nystagmus (Tremor of the Eyeball.)—It may be con- genital, associated with certain ocular troubles, or due to disease of basal ganglia, especially disseminated sclerosis. The Ear. Tinnitus Aurium (Noises in the Ear).—They are observed in cerebral hyperemia and anemia, in diseases of the ear, in Meniere's disease, and after the use of certain drugs like quinine and salicylic acid. Hyperacusis of Hearing.—This is sometimes observed in hysteria, in facial paralysis, and in cerebral hyperemia. Deafness generally depends upon disease of the ear itself. PSYCHICAL DISTURBANCES. Delusion.—A delusion is a faulty belief concerning a subject capable of physical demonstration, out of which the person cannot be reasoned by adequate methods for the time being. (Wood.) A systematized delusion is one which the patient endeavors to defend by a process of reasoning more or less logical. Sys- tematized delusions are especially observed in monomania. An unsystematized delusion is one which the patient makes no attempt to justify ; he asserts his belief without reason. PSYCHICAL DISTURBANCES. 329 The majority of delusions are unsystematized ; and as such are observed in most forms of insanity. A fixed delusion is one which the patient retains for a con- siderable length of time ; it is frequently systematized. Fixed delusions are observed in monomania, paretic dementia, hys- terical insanity, and sometimes in melancholia. An expansive delusion, or a delusion of grandeur, is one which exalts its possessor. The patient conceives that he is some noted personage, that he is worth millions of dollars, or that he is capable of performing certain marvellous feats. Ex- pansive delusions are frequently observed in paretic dementia, mania, and hysterical insanity. A hypochondriacal delusion is one which depresses its possessor. The patient believes that he has committed the unpardonable sin, that he is being persecuted, or that he is the victim of some dread disease. Hypochondriacal delusions are frequently observed in melancholia, alcoholic insanity, and in some cases of monomania and paretic dementia. Illusion.—Au illusion is a perverted perception. Thus in delirium tremens the patient may transform every piece of furniture into a demon or reptile. Hallucination. — An hallucination is a false perception, entirely subjective, and not based upon any knowledge derived from without. An individual who hears voices and sees ob- jects when none exist is the subject of hallucinations. Imperative Conception.—A conception which the person knows to be false, but which, nevertheless, dominates his thoughts and often directs his actions. When he fails to recognize the falsity of his conception, it becomes a delusion. A morbid impulse is an irresistible desire to commit an act which the patient knows to be wrong. It is usually the result of an imperative conception. Kleptomania is a morbid desire to steal. Pyromania is a morbid desire to set fire to buildings. Delirium. Delirium is a mental state characterized by a rapid flight of ideas which are incoherent and often unintelligible. It may result from :— 330 DISEASES OF THE NERVOUS SYSTEM. Acute Delirium (BeWs Mania).—A disease arising without obvious cause, and characterized by an abrupt onset, active delirium, a constant repetition of certain phrases or acts, moderate fever, often a bullous eruption, and exhaustion. It generally ends fatally in the course of a few weeks. Mania.—In this affection the onset is not abrupt. Symp- toms of impaired health and mental depression, covering a period of several weeks or months, generally precede the out- break of the delirium. Hysteria.—The history, age, sex, and temperament, and the intermittent character of the delirium will aid in the diagnosis. One of the Infectious Fevers.—Pneumonia and typhoid fever are especially liable to be associated with delirium. The physical signs in the former and the abdominal symptoms in the latter will usually indicate the diagnosis. Uraemia.—The urinous odor of the breath, the high arterial tension, the accentuation of the second aortic sound, and the presence of albumiu and casts in the urine will suggest uremia. Alcoholism.—The history, the appearance of the patient, the marked tremors, and frequently terrifying hallucinations will indicate alcoholism. Inanition.—A form of delirium occasionally arises in the course of exhausting diseases. It is associated with pallor, feeble pulse, and cold extremities. It is generally of short duration, and may be recognized by the circumstances under which it develops. TUBERCULAR MENINGITIS. 331 TUBERCULOUS MENINGITIS. (Basilar Meningitis, Acute Hydrocephalus.) Definition.—An acute inflammation of the cerebral men- inges excited by the tubercle bacillus. Etiology.—In children the disease may be primary, but in adults it is always secondary to a primary focus of tuber- culosis in some other part of the body. The majority of cases are observed between the second and the fifth years. Heredity, bad hygienic surroundings, and poor food (milk from a tuber- culous mother) are predisposing factors. Pathology.—The basilar meninges are especially involved. The pons, crura, and medulla are covered with soft lymph which mats together in a common mass the adjacent nerves and bloodvessels. The tuberculous character of the inflam- mation is manifested by the presence of small yellowish nodules which are particularly abundant along the bloodvessels in the Sylvian fissures. The amount of fluid in the ventricles is increased, and the ependyma is soft and oedematous.^ The cortical substance underlying the affected meninges is also soft and infiltrated with leucocytes. Symptoms.—The disease usually begius insidiously with certain prodromal symptoms. The disposition of the child changes ; he ceases to play ; he becomes dull and listless, and when disturbed, irritable. Sleep is broken and fitful; the child twitches, grinds his teeth, or starts up with a cry of alarm. Headache develops, and is soon associated with fever and vomiting; the tongue is coated ; the appetite lost; and the bowels constipated. When the disease is fully developed the headache becomes intense, and frequently causes from time to time a shrill scream—the "hydrocephalic cry." The special senses are abnormally acute, so that bright lights and loud sounds cannot be tolerated. The surface is also hyperes- thetic, and when touched, the child becomes extremely irritable. The temperature is moderately high (102°-103°); the pulse is at first rapid, but later slow and irregular ;_ the abdominal walls are retracted ; the muscles of the neck rigid ; and the pupils contracted. Convulsive seizures frequently 332 DISEASES OF THE NERVOUS SYSTEM. develop; they may be general or local. The child lies on one side with the limbs drawn up, the head strongly retracted, and the fingers clinched over the thumb, which is turned into the palm. Towards the close of this stage delirium develops. When the exudate is sufficient in amount to exert marked pressure, paralytic phenomena develop. Local palsies, espe- cially of the facial muscles, take the place of convulsions; coma follows delirium ; the pupils dilate and the eyes roll up; photophobia is replaced by blindness, and intolerance of sound by deafness. If the finger is drawn across the body, a bright red line develops and lingers for some minutes; this is the tdche cerebrate of Trousseau. The pulse now becomes rapid and irregular; the respiration assumes the Cheyne- Stokes type, and the temperature falls. The duration is from one to three weeks. Diagnosis. Typhoid Fever.—Typhoid fever may closely simulate meningitis, especially in the young; but the early development of cerebral symptoms, the irregular fever, the slow pulse of the first stage, the retracted abdominal walls, the constipation, and the absence of rose-colored spots will serve to distinguish meningitis from typhoid fever. Simple Meningitis.—An absolute diagnosis may be impos- sible, but the history of tuberculosis in the family, the presence of tuberculous foci in other parts, the detection of tubercle on the retina, and an onset without obvious cause will generally indicate the true nature of the case. Prognosis.—Absolutely unfavorable. Treatment.—The patient should be placed in a quiet, dark, well-ventilated room. The diet should be liquid. An ice-bag should be applied to the head. Constipation should be relieved by enemata. For the headache, restlessness, and convulsions, chloral and bromide of potassium are useful, and may be given by the rectum. ty_ Moschi, gr. iij ; Camphors?, gr. xv; Chloral, hydrat., gr. viiss ; Yitelli ovi, No. i; Aq. destillat., L§iv.—M. (Simon.) Sig.—Wash out the rectum with a simple enema and inject two ounces. CHRONIC PACHYMENINGITIS. 333 The administration of ergot and of iodide of potassium, and the external application of an ointment of iodoform to the shaved scalp have been recommended, but generally prove useless. SIMPLE LEPTOMENINGITIS. (Acute Leptomeningitis, Meningitis of the Convexity.) Definition.—An acute inflammation of the pia mater not due to tubercle. Etiology.—Traumatism, sunstroke, rheumatism, Bright's disease, and the infectious fevers, are the usual predisposing causes. It occasionally develops from caries of the bone which is secondary to middle-ear disease. Pathology.—The membranes are opaque, thickened, con- gested, adherent, and more or less infiltrated with purulent fluid. Generally the convexity is affected, but in some cases, as those following middle-ear disease, the base is chiefly in- volved. The adjacent cortical substance is also oedematous, soft, and injected. Symptoms.—Moderate irregular fever, loss of appetite, con- stipation, intense headache, intolerance to light and sound, contracted pupils, delirium, retraction of the head, convulsions, and coma. When the base is involved, the symptoms are almost identi- cal with those of tuberculous meningitis. Prognosis.—Unfavorable, though recovery is not im- possible. Treatment.—The patient should be placed in a quiet, dark, well-ventilated room. An ice-bag should be applied to the head. When the patient is robust, wet cups or leeches may be applied to thesneck. The diet must be liquid. Constipa- tion should be relieved by enemata. Restlessness, headache, and convulsions call for chloral and bromide of potassium. CHRONIC PACHYMENINGITIS. Definition.—Inflammation of the dura mater. Etiology.—Inflammation of the external layer may result from injury, syphilis, sunstroke, or caries of the bone. In- 334 DISEASES OF THE NERVOUS SYSTEM. flammation of the internal layer (hemorrhagic pachymeningitis) may be secondary to chronic cardiac or renal disease, one of the infectious fevers, chronic alcoholism, or especially, insanity. Hemorrhagic Pachymeningitis. (Haematoma of the Dura Mater.) Pathology.—The membranes are thickened, opaque, and more or less adherent. The bloodvessels are dilated. Be- tween the membranous layers are frequently observed hemor- rhagic effusions ; these vary in extent from slight ecchymoses to clots as large as a hen's egg. In some cases the pressure of the clots on the convolutions is sufficient to cause the latter to atrophy. Symptoms.—Often obscure. In some cases there are no manifestations during life. When the condition is marked, the following phenomena may be observed : Headache, failure of memory, impairment of intellect, stupor, contracted pupils, local convulsions, or palsies. The symptoms may alternately improve and grow worse for a long period. In grave cases, associated with extensive hemorrhagic effusion, the symptoms resemble apoplexy. Diagnosis.—This can rarely be made with certainty. Prognosis.—Unfavorable. Treatment.—Grave cases should be treated as apoplexy. HYDROCEPHALUS. (Congenital Hydrocephalus, Water on the Brain.) Definition.—A condition in which there is an excessive accumulation of fluid in the ventricles or arachnoid cavity. Etiology.—Acquired, Hydrocephalus may develop at any period of life, and may result from meningitis, the pressure of a tumor, or from one of the causes of general dropsy. Congenital Hydrocephalus, the form now under discussion, dates from birth or develops in the first few years of life. Its cause is unknown ; in some cases it is probably due to a latent inflammation of the ependyma of the ventricles. HYDROCEPHALUS. 335 Pathology.—The head is large and round; the bones are thin and translucent; the sutures and fontanelles are enlarged, and, if life has been prolonged, are filled with numerous Wormian bones. The convolutions of the brain are flattened and the sulci more or less obliterated. In external hydro- cephalus the accumulation of fluid is found in the arachnoid sac; but in internal hydrocephalus—the most common form—the ventricles are greatly distended with a watery fluid of low specific gravity, containing a trace of albumin. The epen- dyma is often thickened and roughened. Malformations are frequently observed, and probably result from the same cause which induced the effusion. Symptoms.-—Sometimes the disease develops before birth, and the large head interferes with the delivery of the child. In other cases nothing peculiar is observed until the child is several months old, when the swelling of the head attracts the attention of the parents. The head assumes a globular shape; the fontanelles and sutures remain open ; the face be- comes relatively small; the eyes protrude and are directed downward from the pressure of the fluid on the supraorbital plates; the scalp appears thin and stretched; the superficial veins are distended; and the hair becomes scant. In some cases the head is so heavy that the thin neck can no longer support it, and it falls forward on the breast. As a rule, the intelligence is considerably impaired, but ex- ceptional cases are marked by precociousness. Motor phe- nomena are frequently present: the reflexes are exaggerated ; one or more of the members may be the seat of a spastic paralysis ; convulsions develop in many cases. The duration varies in different cases. The large majority soon die of inanition, convulsions, or some intercurrent disease to which their reduced vitality makes them an easy prey; but in a few, life is prolonged for many years. Diagnosis.—Hydrocephalus must not be mistaken for rachitic enlargement of the head. In the latter, the head is square instead of globular; the intelligence is good; there are no motor phenomena; and bony enlargements are usually detected at the ends of the long bones and at the junction of the cartilages with the ribs. 336 DISEASES OF THE NERVOUS SYSTEM. Prognosis.—Unfavorable. In a few cases arrest of the disease has been spontaneous, or has resulted from aspiration of the fluid. Treatment.—The treatment is unsatisfactory. Counter- irritation and the use of diuretics and absorbents exert no influence on the disease. In the majority of cases, beyond dietetic and hygienic measures and the occasional use of tonics, little can be recommended. In cases where the pressure- symptoms are marked, tapping offers some hopes of tem- porary relief. After the operation compression of the skull should be made by the application of concentric bands of adhesive plaster. PARETIC DEMENTIA. (General Paralysis of the Insane, General Paresis, Chronic Meningo-encephalitis.) Definition.—A chronic inflammatory affection of the cerebral cortex, characterized by a change of disposition, failure of memory, mental exaltation, delusions of grandeur, tremors, epileptiform seizures, and paralysis. Etiology.—Male sex, middle life, prolonged mental strain, and excesses are predisposing factors. It may be induced by the usual causes of sclerosis, namely, syphilis, alcoholism, lead- poisoning, gout, etc. Pathology.—The membranes are opaque, thickened, and at places, adherent to the brain substance. The cortex is more or less atrophied and increased in firmness. Microscopic examination reveals an overgrowth of connective tissue and degeneration of nerve-fibres and ganglionic cells. In some cases similar degenerative changes are observed in the posterior and lateral columns of the cord. Symptoms.—The disease usually begins insidiously with a change in disposition; the industrious become slothful; the ambitious, apathetic; the chaste, dissolute; the liberal, parsi- monious ; the complaisant, churlish ; and the truthful, false. The energy relaxes, the judgment weakens, and the memory fails. As the faculties become impaired, a peculiar egotism and a mental exaltation develop; the patient becomes boastful, PARETIC DEMENTIA. 337 loquacious, and easily provoked to furious outbreaks. The failure of memory is early noted in writing, by the use of wrong letters and the suppression of syllables. At this time motor phenomena may be observed : the tongue trembles when it is protruded ; the speech is slow, hesitating, and indistinct; the pupils are often unequal; and the gait is somewhat shuffling. The most characteristic psychical symptom of fully-de- veloped paretic dementia is the delusion of grandeur: the patient conceives that he is some distinguished personage, that he owns acres of land, or that he is the inventor of some wonderful machine. The mind is usually serene and cheerful, but periods of depression are not infrequent. The sensibilities are blunted and the animal nature emphasized. The mind becomes more and more involved ; there is extreme indifference to all that transpires; the appetite is voracious, and in eating the patient bolts his food and soils his clothes. The tremor of the tongue increases, and spreads to the lips and other parts of the face; the speech is indistinct and " scanning ;" the pupils fail to respond to light, but still accommodate for distance (A rgyll-Robertson pupil) ; the reflexes are generally increased. Spellsof unconsciousness resembling petit mal are not uncommon. In the final stage mental power is almost obliterated ; the health fails ; the bladder and rectum become unretentive ; the gait is more unsteady; and at last the patient is unable to leave his bed. Death usually results from exhaustion or in- tercurrent disease. Diagnosis.—The insidious change in disposition, failure of memory, tremors, Argyll-Robertson pupil, and delusions of grandeur are the diagnostic features. Cerebral Syphilis.—In this disease the history, the occur- rence of convulsions and of partial facial palsies, the absence of delusions of grandeur and of " scanning" speech, and the effect of treatment will usually prevent an error in diagnosis. Prognosis.—Unfavorable. The course is not uniform ; in some cases there are remissions, or lucid intervals, which last several months or years. The average duration is three or four years. Treatment.—Rest of body and mind. Careful attention 22 338 diseases of the nervous system. to the hygiene. When there is a suspicion of syphilis, iodides and mercurials should be given a thorough trial. As a rule, patients must be removed to asylums. CEREBRAL PARALYSIS IN CHILDREN. Definition. — Hemiplegia, diplegia, or paraplegia ap- pearing at birth or in the first few years of life, and usually associated with atrophy and sclerosis of the cerebral cortex, or porencephalus. Pathology.—After death one of the following conditions is observed : Atrophy and sclerosis of the convolutions; poren- cephalus (a cystic condition of the cortex); or more rarely, some local obstruction to the cerebral circulation, as from hemorrhage, embolism, or thrombosis. The exciting cause of the porencephalus aud sclerosis is still undetermined. Symptoms.—In the hemiplegic variety the onset is sudden, and is frequently attended with fever, convulsions, or coma. After a few hours or davs these severe symptoms subside, and the child is left paralyzed on one side of the body. In rare instances the paralysis ultimately disappears and the child is resto'red to health, but in the large majority of cases it persists and is followed by secondary rigidity. Imbecility, epilepsy, and choreiform or athetoid movements in the affected members are very common sequele. The diplegia or paraplegic form frequently dates from birth, and is characterized by rigidity and loss of power in all of the extremities. The legs suffer more than the arms. Chorei- form or athetoid movements are frequently present. Children thus affected are generally idiots or imbeciles. Meningeal hemorrhage, induced by tedious labor or the use of the for- ceps, appears to be responsible for this variety. Treatment.—During the convulsive stage an ice-bag should be applied to the head, and chloral or bromide admin- istered by the mouth or rectum. The paralysis resists treat- ment ; but subsequent rigidity may be lessened by massage and passive movements, and the deformity by mechanical appliances.1 1 The above description is based upon Osier's elaborate monograph. CEREBRAL hyperemia. 339 CEREBRAL HYPEREMIA. (Congestion of the Brain.) Etiology.—Acute congestion results from exposure to the sun ; from the use of certain drugs, like alcohol and nitro- glycerine; from excesssive brain-work; or from some reflex disturbance, as gastric irritation. Chronic congestion results from some local obstruction to the return of blood from the brain, as by a tumor in the neck; from obstruction to the general circulation, as in chronic heart and lung disease; from the suppression of some habitual dis- charge, as the menstrual flow at the menopause ; or from some general cause, such as prolonged anxiety, overwork, excesses, irregular living, etc. Pathology.—The vessels of the meninges and of the brain-substance are engorged. Symptoms. Acute Form.—Intense headache ; vertigo ; intolerance to light and sound ; restlessness ; tinnitus aurium ; and sleeplessness, or sleep disturbed by horrible dreams. Chronic Form. — Arertigo; dull headache; failure of , memory ; irritability; inability to concentrate the thoughts; and disturbed sleep. The symptoms grow worse when the re- cumbent posture is assumed. Ophthalmoscopic examination reveals retinal hyperemia. In marked cases there may be exacerbations closely resembling apoplexy, in which there is unconsciousness, followed by temporary paresis. Prognosis.—Depends on the cause; when this can be removed the prognosis is favorable. Treatment. Acide Congestion.—The patient should be placed in a darkened, well-ventilated room. The head and shoulders should be slightly elevated. An ice-bag should be applied to the head. Leeches or wet-cups may be applied to the neck. Sedatives like bromide of potassium and aconite are useful. Ergot may be employed for its power to contract the vessels. If there is constipation, it should be relieved by a brisk saline purge. # In chronic cases the cause should be ascertained and, if possible, removed. The habits of the patient must be regu- 340 DISEASES OF THE NERVOUS SYSTEM. lated. The diet must be light and nutritious. Constipation must be relieved by diet or by the occasional use of a saline laxative. Sedatives like bromide of potassium and aconite are useful. In the apoplectiform attacks venesection is indicated. CEREBRAL ANEMIA. Etiology.—General cerebral anemia as a chronic affection may result from cardiac disease, especially aortic stenosis. It may be associated with general anemia. It may be due to atheromatous obstruction of the arteries. Overwork, prolonged emotional excitement, irregular living, and excesses are also said to predispose. As an acute condition it exists in syncope and shock ; after hemorrhage; after the sudden withdrawal of fluid from the abdominal sac; and after ligation of the carotid artery. Symptoms. Acute Form.—Pallor of the face, vertigo, confusion of ideas, ringing in the ears, dimness of vision, dila- tation of the pupil, nausea, and a tendency to yawn. In extreme anemia there may be convulsions and coma. The chronic form is characterized by vertigo, headache, dis- turbed sleep, intolerance to light and sound, irritability of temper, failure of memory, inability to concentrate the atten- tion on one subject, a tendency to syncope, and extreme lassi- tude. The symptoms improve when the patient lies down. Ophthalmoscopic examination reveals pallor of the retina. Diagnosis.—Cerebral anemia closely simulates cerebral congestion, but in the latter there is no tendency to syncope ; the symptoms grow worse when the patient lies down; and the ophthalmoscope reveals retinal hyperemia. Prognosis.—Depends on the cause; when this can be re- moved the prognosis is favorable. Treatment.—In acute cases diffusible stimulants like nitro-glycerin, ammonia, and strychnia are indicated. In chronic cases the cause should be ascertained, and if possible, removed. When it is due to general anemia, iron, arsenic, and quinine are useful remedies. When dependent on valvu- lar disease, rest and the use of digitalis, strophanthus, or strychnia are the remedial measures. CEREBRAL HEMORRHAGE. 341 CEREBRAL HEMORRHAGE. (Cerebral Apoplexy.) Etiology.—The affection is most commonly met with in the old, in whom the bloodvessels are atheromatous, and in the very young, in whom they are naturally weak. All causes which lead to degeneration of the arteries, such as rheumatism, gout, syphilis, alcoholism, and Bright's disease, predispose to it. Sufferers from chronic Bright's disease are very liable to die of apoplexy on account of the association of cardiac hypertrophy with arterial degeneration. Heredity predisposes, inasmuch as members of certain families are particularly prone to sclerosis of the vessels. The attack may be precipitated by mental or physical excitement, alco- holic excess, or some reflex disturbance, as gastric irritation. In children it may be excited by a paroxysm of whooping- cough or by a convulsion. Pathology.—In children the hemorrhage is most com- monly cortical; in adults it is usually within the brain-mass. The bloodvessels are generally atheromatous, and are some- times the seat of miliary aneurisms. The clot varies greatly in size; sometimes it is small, merely a capillary oozing; at other times it may fill a hemisphere. Its most common seat is the internal capsule—the motor highway between the optic thalamus and the corpus striatum. In recent hemorrhages the clot is dark and soft, and the surrounding tissue stained and more or less lacerated. If the hemorrhage has not been very copious, the clot loses it color, shrinks, and is finally absorbed, and the damaged cerebral fibres are replaced by proliferated connective tissue, which contracts and forms a scar more or less pigmented with hematoidin. In other cases, instead of a scar, a cyst is formed which encloses a clear straw- colored fluid. Large effusions in the motor path may produce secondary changes—either a softening of the cerebral tissue beyond, or a degeneration which travels down the lateral column of the cord on the side opposite the lesion. Symptoms.—Prodromal symptoms indicating cerebral con- gestion frequently precede the attack; these are headache, 342 diseases of the nervous system. vertigo, disturbed sleep, tinnitus aurium; or there is a sense of numbness or weakness on the side which is to be affected. Persistent vomiting sometimes precedes the hemorrhage. The Attack.—In many cases the patient falls suddenly un- conscious without previous warning. The face is flushed; the eyes are injected ; the lips are blue; the breathing is ster- torous ; the pulse is full and slow; the temperature is at first subnormal from shock, but later it is elevated from irritation; and the urine and feces may be passed involuntarily. Convul- sive seizures are not infrequent; they result from irritation transmitted to the undamaged motor regions. Even while the patient is comatose the paralysis can be detected. The head and eyes may be strongly rotated to one side (conjugate devia- tion) ; one cheek often flaps more than the other; the pupils may be irregular; any movements which the patient may make are restricted to the sound side; when the affected arm is raised and let fall, it drops lifeless or manifests an unnatural rigidity; and occasionally there is a difference of temperature in- the two axille. In grave cases the patient does not awake from the coma; the pulse grows feeble ; the respirations assume the Cheyne-Stokes type; the reflexes are abolished; mucus col- lects in the throat and produces a rattling sound ; the tempera- ture rises high ; and death results after the lapse of a few hours or one or two days. In some cases the paralysis develops quite gradually and is not attended with unconsciousness. Subsequent Symptoms. — When the attack does not prove fatal, consciousness is finally restored, and if the hemorrhage is in its usual location, there remains a hemiplegia on the opposite side. In a few hours the affected muscles become rigid from irritation of the motor fibres. This early rigidity is termed primary rigidity; it lasts from a few days to several weeks and has no significance from a prognostic standpoint. The paralysis is rarely a complete hemiplegia ; the muscles of the upper part of the face and thorax usually escape, because they are accustomed to act in unison with their fellows on the op- posite side, and such muscles are rarely involved in cerebral hemiplegia. When the tongue is protruded, it deviates toward the paralyzed side. The deep reflexes are exaggerated on CEREBRAL HEMORRHAGE. 343 the affected side. Sensation is unimpaired unless the pos- terior limb of the internal capsule is also involved, when there is hemianesthesia with hemiplegia. The gait is peculiar; in walking the patient supports the paralyzed arm, and swings the leg forward by a rotary movement imparted to it by the trunk. AVhen the clot has been small, the paralysis may completely disappear. More frequently recovery is only par- tial ; the power of the facial muscles is usually restored entirely, and the leg improves more than the arm. In unfavor- able cases the muscles again become rigid (secondary rigidity) from a degenerative process travelling down the lateral column of the cord; this condition is indicative of permanent dis- ability. Generally the mental power remains unimpaired, but sometimes the symptoms of cerebral softening gradually develop. Diagnosis.—The coma of apoplexy must be distinguished from uraemia, opium-poisoning, alcoholism, and sunstroke. The age of the patient; the condition of the arteries ; the evidence of paralysis ; the difference of temperature in the two axille; and the absence of other cause will usually prevent an error in diagnosis. Embolism.—This usually occurs in earlier life; it is com- monly associated with valvular disease; the paralysis is almost invariably on the right side; aphasia is more common; there is less disturbance of temperature ; and consciousness may not be lost. Thrombosis. — This also produces hemiplegia, but its de- velopment is very gradual. Hemiplegia from other Causes.—Tumors and abscess in the brain may produce hemiplegia, but the latter develops gradu- ally and is usually associated with other cerebral phenomena, such as persistent headache, vertigo, ocular palsies, choked disk, etc. Hysterical Hemiplegia.—In hysteria the face escapes ; there is frequently anesthesia on the affected side ; the gait is pecu- liar, in that the patient pushes the paralyzed limb instead of swinging it. These features together with the age, tempera- ment, sex, and mode of onset will usually suggest the true cause. 344 diseases of the nervous system. Prognosis.—Always doubtful. Persistent and complete unconsciousness, high temperature, loss of reflexes, and embar- rassed respiration are unfavorable phenomena. AVhen the at- tack does not prove fatal, there is always a probability of subsequent ones, for the etiological conditions still remain. Treatment. Prophylaxis.—Patients predisposed to apo- plexy should lead a quiet life, free from mental and physical excitement. The diet should be nutritious, but easily diges- tible. Constipation should be relieved by the occasional use of a saline laxative. To secure a free return of the blood from the brain the clothes at the neck should be loose. The Attack,—The head and shoulders should be slightly elevated, and an ice-bag applied to the head. Croton oil (gtt. j—iij) in a little glycerine or olive oil may be placed on the back of the tongue to secure prompt catharsis. If the pulse is strong, venesection is indicated and should be con- tinued until the pulse softens. Bleeding cannot undo the damage already done, but by relieving cerebral congestion it may prevent a renewed outpouring. On the other hand, when the face is pale and the pulse feeble the hypodermic injection of diffusible stimulants, like ammonia and strychnia, is indi- cated. AVhen collections of mucus interfere with breathing, the patient should be gently turned on his side and the mucus removed. To prevent the formation of bedsores the position should be frequently changed, and the parts subjected to pressure thoroughly cleansed. Subsequent Treatment.—As other attacks are liable to occur, the prophylactic treatment already referred to is applicable here. Iodide of potassium (gr. v-x thrice daily) may be ad- ministered with the hope of absorbing the clot. After the primary rigidity has disappeared, galvanism, massage, and passive movements should be applied to the affected muscles. Strychnia by the mouth or injected directly into the muscles is often very useful. Even when the paralysis remains, con- tractures may be prevented to a considerable extent by massage. obstruction of the cerebral arteries. 345 OBSTRUCTION OF THE CEREBRAL ARTERIES. (Embolism, Thrombosis.) Etiology.— Cerebral emboli may be derived from the valves of the heart in endocarditis ; from an atheromatous plate in the aorta; or from a clot in the heart or in the sac of an aneurism. Obstruction from embolism may occur at any age, but it is far more commonly observed in young adults than at the extremes of life. Thrombi are clots formed in the vessels, and a weak heart and arterial degeneration are the predisposing factors. They are usually observed in advanced years, but those dependent on syphilitic arteritis frequently occur in early adult or middle life. Pathology. — Emboli are most frequently found in a branch of the left middle cerebral artery. When the artery obstructed is a large one, the part beyond usually becomes pale and soft; but sometimes it presents the appearance of an infarction and is infiltrated with blood. Subsequently, microscopic examination reveals fatty degeneration of the nervous elements and more or less pigmentation from ext.-a- vasated blood. If the area affected is small, absorption may follow and scar-tissue be substituted. Thrombi are usually found in the middle cerebral, basilar, or vertebral arteries, and are followed by similar changes. Symptoms.—An embolus lodging in the middle cerebral artery usually causes abrupt hemiplegia, and frequently aphasia. There may be no prodromes, and consciousness is often preserved during the seizure. AVhen the basilar artery is obstructed, there may be exten- sive paralysis on both sides of the body, and later, symptoms of bulbar disease, namely, paralysis of the lips, pharynx, and oesophagus, disturbance of the heart, and Cheyne-Stokes breathing. In thrombosis the symptoms are similar to embolism, but they develop very slowly, and are frequently preceded by prodromes indicating disturbed cerebral circulation, such as headache, vertigo, disturbed sleep, failure of memory, numbness and tingling in the limbs to be affected. 346 diseases of the nervous system. Subsequent Symptoms.—In both embolism and thrombosis, if the artery obstructed has been large, the paralysis persists and symptoms of cerebral softening appear—namely, failure of memory, vertigo, headache, disturbed sleep, great irrita- bility, and finally dementia. Diagnosis.—Cerebral embolism closely resembles apoplexy, and sometimes it may be impossible to distinguish between the two conditions. The following are the diagnostic features :— Embolism is generally associated with valvular disease ; it commonly occurs in the young; prodromes are frequently ab- sent ; the left middle cerebral artery being almost invariably involved, the hemiplegia is on the right side ; aphasia is more common in embolism than in hemorrhage; there is much less disturbance of temperature after embolism than after apo- plexy ; consciousness is less apt to be lost in embolism than in apoplexy. Prognosis.—In embolism it is very doubtful; recovery may follow, but often the paralysis remains. In thrombosis there is very little hope of recovery, unless the cause is syphilis. Treatment.—After obstruction from embolism the patient should be kept at absolute rest for a few days, and subsequently the paralysis treated as after apoplexy. In thrombosis treat- ment is of no avail, save in syphilitic subjects, when mercurial inunctions should be employed freely and the bichloride given by the mouth. CEREBRAL SOFTENING. Definition.—Degeneration of the brain-substance resulting from perverted nutrition. Etiology.-—Local softening may result from obstruction to the circulation by a tumor, embolism, thrombosis, or clot. Extensive softening may result from prolonged cerebral anemia or congestion. It is most frequently observed in old people in association with atheromatous arteries. Pathology.—The affected portion is dull white or reddish- yellow, according to the amount of blood-pigment present; and is less firm than the surrounding brain-substance. Some- times it is so soft that when the brain is cut a creamy fluid morbid growths in the brain. 347 flows out. Microscopic examination reveals destruction of the nerve-elements and their substitution by granular debris and fat-drops. Symptoms.—When extensive the symptoms are: Failure of memory, irritability of temper, vertigo, headache, partial palsies, cutaneous anesthesia or paresthesia, delusions, and finally dementia. Local softening may be manifested by local paralysis. Diagnosis. Cerebral Tumor.—Tumors usually develop in younger subjects ; the headache is more severe; choked disk is frequently observed. Prognosis.—Unfavorable. Treatment.—Palliative. MORBID GROWTHS IN THE BRAIN. (Tumors of the Brain.) Etiology.—Early adult life, male sex, and perhaps trau- matism predispose. Heredity also predisposes to the extent that it favors the development of cancer, gumma, and tubercle. Varieties. — Tubercle, gumma, glioma, cysts, sarcoma, and carcinoma are the most common varieties. Less frequently fibroma, psammoma, and lipoma are observed. Pathology.—Tuberculous tumors, or tyromata, vary in size from a pea to an egg; they may be single or multiple; aud are usually observed in the young. Gumma,—This appears as a round, yellow, caseous mass, and is nearly always on the surface of the brain, into which it grows from the overlying membranes. It is usually met with between thirty and forty. Glioma.—This tumor is found almost exclusively in the brain. It arises from the neuroglia, and may be soft like brain-substance or firm like fibrous tissue. It is chiefly met with in the young. Oysts.—These are usually congenital (porencephalus), but sometimes they result from the tenia echinococcus (hydatid cyst). Sarcoma.—This is usually a diffuse tumor, and grows from the membranes. 348 diseases of the nervous system. Carcinoma.— This is nearly always secondary and multiple. Symptoms.—(1) Headache is rarely absent; it may be localized and associated with tenderness on pressure. (2) Vomiting is a common symptom, especially in tumors of the base of the brain ; it is often unassociated with nausea and docs not relieve the attending headache. (3) Ocular phe- nomena, as optic neuritis, or choked disk, optic atrophy, diplo- pia, hemianopia, blindness, and irregular pupils. (4) Vertigo. (5) Psychical phenomena, as failure of memory, irritability of temper, depression of spirits, and dementia. (6) Symp- toms resulting from local pressure, such as local palsies or convulsions, aphasia, and local anesthesia. Diagnosis.—This includes: (1) the existence of a tumor (2) its character, and (3) its location. 27te existence of a tumor is determined by the headache, vomiting, optic neuritis, and symptoms of local pressure. Abscess. — Cerebral tumor must be distinguished from abscess. The latter usually results from traumatism or is secondary to a focus of suppuration in some other part of the body; its progress is more rapid; choked disk is rare • and there is often febrile disturbance. Chronic Meningitis.—In this affection the symptoms indi- cate a diffuse lesion; disturbances of temper, memory, and sleep are more marked; and optic neuritis is rarely observed The Character of the Growth.—This cannot always be deter- mined. The early age, the rapid progress, and "the family history may suggest tubercle. The early age, slow progress and mild pressure-symptoms may suggest glioma. The his- tory, age, and concomitant symptoms will indicate syphilis Ihe presence of a primary growth will lead to the diagnosis ot cancer. & Location.—The following facts relating to cerebral localisa- tion will aid in determining the location of the orowth Motor area.^ This consists of the ascending frontal and ascending parietal convolutions, and the paracentral lobule which lies along the median fissure. AVhen the tumor irritates he part, convulsion results; when it exerts enough pressure to destroy function, paralysis results. morbid growths in the brain. 349 Paracentral lobule—spasm or paralysis of a lower ex- tremity. Centred portion of the motor area—spasm or paralysis of one arm. The lower portion of the motor area—spasm or paralysis of one side of the face. Posterior part of the third frontal convolution (left side)— motor or ataxic aphasia. Anterior portion of the frontal lobes—sometimes psychical disturbances; often no special symptoms. Temporal lobe, first and second, convolutions (left side)—word- deafness. Parietal lobe—sensory disturbances on opposite side of body. Angular and supramarginal gyri (left side)—word-blindness and mind-blindness. Occipital lobe—hemianopia, and sometimes word-blindness and mind-blindness. Corpus striatum—large lesions produce hemiplegia from pressure on the internal capsule. Optic thalamus—large lesions may produce hemianesthesia from pressure upon the posterior limb of the internal capsule, and sometimes hemianopia. Corpora quadrigemina—hemianopia, nystagmus, and symp- toms resulting from pressure on the crura cerebri. Crus cerebri—hemiplegia on one side, and paralysis of the oculo-motor nerve on the other. Pons—paralysis of the cranial nerves, and in many cases hemiplegia and hemianesthesia on one side, and facial paralysis on the other. Bilateral lesions may produce general paralysis. Internal capsule {middle third)—hemiplegia on the opposite side. Posterior third—hemianesthesia on the opposite side. Medulla—paralysis of the cranial nerves, difficult articu- lation, cardiac and respiratory disturbances, vomiting, and sometimes hemiplegia. Cerebellum (middle lobe) — staggering gait, vomiting, vertigo, and marked headache. Prognosis.—When the tumor is not gummatous, and is not suitable for operative interference, the prognosis is unfavor- able. The duration is from a few months to several years. 350 DISEASES of the nervous system. Treatment.—Localized cortical growths, which are not malignant or syphilitic, are suitable for operative interference. In cerebral gumma inunctions of mercury should be employed, and mercury and iodide of potassium given by the mouth. In other cases the treatment is palliative. Cold applications to the head, bromides, antipyrin, and morphia are required to relieve pain. ABSCESS OF THE BRAIN. (Suppurative Encephalitis.) Etiology.—(1) It may be traumatic. (2) It may be se- condary to suppurative inflammation of adjacent partsj as caries of the temporal bone following otitis media. (3) It may be secondary to some distant focus of suppuration, as in pulmonary abscess, hepatic abscess, ulcerative endocarditis. (4) It may follow one of the infectious fevers. Pathology.—The abscess varies in size from a pea to one large enough to fill an entire hemisphere. The surrounding tissues are hyperemic, oedematous, and more or less infiltrated. In the acute form the abscess is diffuse, but in long-standing cases the pus is encapsulated by a thick fibrous sac. The temporo-sphenoidal lobe and the cerebellum are the most frequent seats. Abscesses secondary to distant foci of sup- puration are commonly multiple. Symptoms.—Abscesses following injury frequently run an acute course, and are characterized by high fever, rigors, head- ache, delirium, convulsions, vomiting, and coma. In chronic cases the general symptoms are headache, irrita- bility, mental impairment, vertigo, vomiting, irregular fever, stupor, pallor, and loss of flesh and strength. The focal phenomena vary with the location of the abscess. Involve- ment of the motor area may be attended with convulsions or paralysis in one limb; of the temporo-sphenoidal lobe, with deafness, and perhaps aphasia; of the occipital lobe, with hemianopia; of the cerebellum, with persistent vomiting and loss of coordination. Diagnosis. Cerebral Tumors.—The history of traumatism or of some primary suppurating disease, such as otitis, bron- CRETINISM. 351 chiectasis, empyema, ulcerative endocarditis; the presence of fever, and the absence of choked disk will indicate abscess. Acute cases can rarely be distinguished from suppurative meningitis. . Prognosis.—Grave. AVhen the focal symptoms indicate involvement of an accessible region like the motor area, temporo-sphenoidal lobe, or cerebellum, operative interference affords considerable hope of success. Treatment.—AVhen the abscess is located in one of the regions specified, the skull should be trephined and the pus evacuated. In other cases the application of wet cups to the neck, of ice-bags to the head, and the internal use of opium, bromide of potassium, or of chloral, may temporarily relieve the distress. CRETINISM. Definition.—A congenital affection, characterized by a lack of phvsical development, an abnormal condition of the thyroid gland, myxcedema, and idiocy or imbecility. Etiology.—Beyond heredity no cause is known. The condition is endemic in the Alps and Pyrenees. Sporadic cases are also observed in other parts of the world. Symptoms. Endemic Cretinism. — The stature is short (three or four feet); the head is large, flat antero-posteriorly and broad laterally ; the eyes are wide apart; the nose is flat; the lips are thick; the tongue is large and may protrude from the mouth; the chest is narrow ; the belly is prominent; the fingers are short; the genitalia are not developed; the sub- cutaneous tissues, especially at the root of the neck, are thickened from mucoid or fatty deposits; the thyroid gland is frequently enlarged; and the mental condition is that of idiocy. Sporadic cases present the same features, but the thyroid, instead of being larger, is often atrophied Congenital conditions presenting to a limited extent the phenomena of cretinism are not uncommon, and are termed cretinoid. 352 DISEASES OF THE NERVOUS SYSTEM. SPINAL LEPTOMENINGITIS. (Spinal Meningitis.) Definition.—An inflammation of the spinal pia mater not associated with infectious cerebro-spinal meningitis. Etiology.—The infectious fevers, exposure to cold and wet, traumatism, and tuberculosis are the etiological factors. Pathology. Acute Form.—The membranes are opaque, thickened, congested, and adherent. The fluid in the arach- noid space is increased. In very acute cases there is more or less purulent infiltration. The periphery of the cord is al- ways involved. Chronic Form.—The membranes are very thick and fused iuto one homogeneous fibrous mass. Symptoms. Acute Form.—The disease may begin with a chill, which is followed by moderate fever. There is intense pain in the back radiating along the course of the nerves. The back is exquisitely tender. The spinal muscles are rigid and contracted, sometimes so much so as to induce opisthot- onos. The reflexes are increased. AVhen the exudate is sufficient to make considerable pressure on the cord, paralytic phenomena develop, such as slight anesthesia and partial paralysis of the extremities. There are no cerebral symptoms unless the meninges of the brain are involved. Diagnosis. Myelitis.—In this affection there are marked paralysis and anesthesia; involvement of the bladder and rectum; and the formation of bedsores Rheumatism of the Muscles and Fibrous Tissues of the Back.— In this condition the joints are involved; the urine is highly acid; the pain does not follow the nerve-trunks; and the symptoms yield to the salicylates. Tetanus.—The presence of a wound ; the absence of fever; the early involvement of the jaw; and the absence of exquisite tenderness in the back will separate tetanus from meningitis. Prognosis.—Extremely grave. Recovery sometimes fol- lows, but rarely without partial paralysis. Chronic Leptomeningitis.—Pain in the back; stiffness of CHRONIC SPINAL PACHYMENINGITIS. 353 muscles; hyperesthesia and paresthesia of the lower extremi- ties, but rarely any anesthesia; some loss of power; and increased reflexes. Treatment.—An ice-bag, leeches, or cups may be applied to the spine. Sedatives like chloral, bromides, and morphia are usually required. Warm baths relieve the pain and lessen the rigidity. Ergot and iodide of potassium are recommended. If the acute symptoms subside, iodide of potassium may be administered internally; blisters and mercurial inunctions may be applied to the spine, and massage and electricity to the affected muscles. CHRONIC SPINAL PACHYMENLNGITIS. (Cervical Hypertrophic Pachymeningitis, Internal Pachymeningitis.) Definition.—A chronic inflammatory affection of the dura mater, characterized by severe pains in the head, shoulders, arms, and loins, followed by paresis, wasting, and anesthesia. Etiology.—Male sex, middle life, prolonged exposure to cold, lowered vitality,spinal concussion, alcoholism,and syphilis are predisposing factors. It may be secondary to inflammation of neighboring structures, such as the vertebrae in Pott's disease. Pathology.—The membranes are thickened, opaque, and adherent; the vessels are dilated ; and the spinal fluid is in- creased. In advanced cases the membranes are glued together and form a thick, homogeneous, fibrous mass. The cervical region is most commonly affected. The inflammation may extend to the cord and peripheral nerves. Symptoms.—Sharp pains radiating into the head, shoulders, arms, and loins, followed by loss of power, anesthesia, wast- ing, and rigidity, particularly in the upper extremities. AVhen the lower part of the cord is involved the same phenomena are observed in the legs. The duration of the disease is several years. Diagnosis. Chronic Poliomyelitis.—The absence of pain and of anesthesia will separate poliomyelitis from pachy- meningitis. 354 DISEASES OF THE NERVOUS SYSTEM. Multiple Neuritis.—In this affection the pain is less marked in the back and more marked in the extremities, and the nerve- trunks are tender on pressure. Spinal Irritation.—In this condition the spine is tender at certain spots, and there is no radiating pain, anesthesia, or wasting. Prognosis.—This depends on the extent and cause. AVhen the involvement is slight or is due to syphilis, the prognosis should be guardedly favorable. Treatment.—Absolute rest. Tonics are often indicated. Counter-irritation should be made along the cord by frequent blisters or the actual cautery. Morphia, antipyrin, or phena- cetin may be required for the relief of pain. Iodide of potas- sium may be administered for its absorbent effect, and in syphilitic cases it should be given freely in conjunction with some mercurial. ACUTE MYELITIS. Definition.—An acute inflammation of the substance of the cord, characterized by marked disturbances of motion, sen- sation, and nutrition. Varieties.—AVhen only a transverse section is involved the condition is termed transverse myelitis. When a large vertical section is affected the disease is termed diffuse myelitis. AVhen the gray matter is especially involved it is termed central myelitis. Etiology.—Traumatism; exposure to cold, especially when the body is overheated; over-exertion; alcoholism; syphilis; or the infectious fevers may induce it. It is sometimes secondary to a hemorrhage or a morbid growth in the cord. Pathology.—The membranes are usually injected and opaque. The substance of the cord is red and soft, and the line of demarcation between the gray and white matter is in- distinct. In very acute cases the substance of the cord may flow out as a reddish, creamy fluid when the membranes are cut. Occasionally there are conspicuous hemorrhagic effusions (hematomyelitis). Microscopic examination reveals destruction of the nerve- acute myelitis. 355 elements, and in their place granular debris, fat-globules, red blood-corpuscles, and leucocytes. Symptoms. Acute Transverse Myelitis.—Moderate fever (101°-103°), loss of appetite, coated tongue, and constipa- tion, followed by pain in the back radiating into the limbs. With the pain there are often various forms of paresthesia, as numbness, tingling, burning, etc. The muscles may be the seat of tremors or of convulsive seizures. There is frequently a sense of painful constriction—"girdle pain"—at the level of the disease. Paralysis soon develops, and may become more or less complete. The reflexes are generally increased when the lesion is above the lumbar enlargement; but if the latter is involved they are lost. The paralyzed muscles are flabby, but do not yield the reactions of degeneration; when, how- ever, the reflexes are exaggerated the muscles often become rigid and contracted. At first there may be retention of urine and feces, but later there is frequently incontinence. Anesthesia is more or less complete. Bedsores soon develop and add to the distress of the patient. Death may result in a few days from extension upward and involvement of the respiratory muscles. In many cases life is prolonged for several weeks, death finally resulting from exhaustion induced by bedsores and cystitis. In rare cases there is a spontaneous arrest of the inflammation, and slow recovery follows, attended with partial paralysis. Acute Centred Myelitis —This resembles the former, but the trophic disturbances are much more marked and the dura- tion is shorter. The disease is characterized by moderate fever and its associated phenomena, pain in the back, complete loss of power and of sensation, loss of reflexes, incontinence of urine and feces, rapid wasting of the muscles, and the early development of bedsores. The disease invariably proves fatal in from one to two weeks. Diagnosis. Acute Poliomyelitis.—In this disease the blad- der and rectum are not involved, and there are no sensory disturbances. Landry's Disease, or Acute Ascending Paralysis.—In this affection trophic disturbances are absent; the bladder and rectum are not involved; and the loss of sensation is slight. 356 DISEASES OF THE NERVOUS SYSTEM. Midtiple Neuritis.—The "girdle pain" is absent; the sphinc- ters are not affected ; bedsores are rare ; and pain is more marked in the extremities than in the back. Meningitis—The girdle pain is absent; the sphincters are not affected ; the irritative phenomena are more marked than the paralytic. Hemorrhage into the Cord. — The paralysis develops ab- ruptly. Prognosis. — Always extremely grave. Acute central myelitis is invariably fatal. In other cases recovery attended with partial paralysis occasionally follows. Treatment.—If possible, the patient should be placed on a water-bed. To delay the formation of bedsores extreme cleanliness is essential. Both in retention and incontinence of urine the catheter should be used twice daily. In incontinence of urine and feces the discharges should be received on cotton- wool or oakum, which should be frequently renewed and the parts thoroughly cleansed. In the beginning an ice-bag or wet cups maybe applied to the spine. Such remedies as ergot, belladonna, quinine, and mercury are frequently employed, but they seem to exert little influence. If recovery should follow, massage, electricity, and strychnia may be employed with the hope of restoring power to the paralyzed muscles. CHRONIC MYELITIS. Etiology.—Middle life, continued exposure to cold and wet, syphilis, alcoholism, gout, traumatism, and excesses are the predisposing factors. It may be secondary to Pott's disease. Pathology.—The membranes are opaque and adherent. The whole cord has a grayish color; it is firmer than normal and somewhat contracted. Microscopic examination reveals destruction of nerve-ele- ments, and their replacement by an overgrowth of connective tissue. Symptoms.—The disease begins gradually with numbness, tingling, or burning in the lower extremities, followed bv a loss of power and sensation. The reflexes are generally exagger- ated. The sphincters soon become involved. The muscles do SCLEROSIS OF THE SPINAL CORD. 357 not waste until the disease is far advanced. As in other organic affections of the cord, there is often a sense of constric- tion, or "girdle pain," at the level of the disease. The disease progresses very slowly, the duration being from six months to ten years. Diagnosis.—The diagnosis rests on the gradual develop- ment of symptoms indicating a general involvement of the cord. Treatment.—The patient should be put at rest; tonics are often indicated ; counter-irritation to the spine by repeated blisters or applications of the actual cautery, often yields good results. The frequent use of tepid baths is also beneficial. The special remedies which have been recommended are arsenic, strychnia, phosphorus, nitrate of silver, mercury, and iodide of potassium. When there is a suspicion of syphilis the last two remedies should be given a thorough trial. SCLEROSIS OF THE SPINAL CORD. (Duchenne's Disease.) Definition.—A degenerative affection of the spinal cord, characterized anatomically by an atrophy of the nerve-elements and an overgrowth of connective tissue. Etiology.—Middle life, male sex, syphilis, alcoholism, mineral poisoning, excesses, and continued exposure to cold and wet are the usual causes. Locomotor Ataxia. (Locomotor Ataxy, Tabes Dorsalis, Posterior Sclerosis.) Definition.—A sclerosis affecting the posterior columns of the cord, and characterized by incoordination, loss of deep reflexes, disturbances of nutrition and of sensation, and various ocular phenomena. Pathology.—The membranes over the posterior columns are often opaque and adherent. The posterior columns have a grayish color, and are firm and shrunken. Microscopic examination reveals atrophy of the nerve- fibres and an overgrowth of connective tissue. Degenerative 358 DISEASES OF THE NERVOUS SYSTEM. changes are frequently observed in the basal ganglia and in the peripheral nerves. Symptoms. Motor Phenomena. — One of the earliest symptoms is loss of coordination. This is first manifested by unsteadiness when the patient walks in the dark. AVhen he stands erect, with the eyes closed and feet together, he staggers and tends to fall (Romberg's symptom). AVhen the arms are affected there is inability to perform work requiring delicate coordination, such as writing and piano-playing. This loss of coordination in the upper extremities becomes conspicious when the patient, while his eyes are closed, at- tempts to touch the tip of his nose. The gait is characteristic; in walking he raises his feet high, throws them forwards, and brings them down forcibly in such a way that the whole sole strikes the floor at once. Although the patient may be unable to walk or to use his hands with precision, there is no actual loss of power. Sensory Phenomena.—Pain is rarely absent; it is sharp and lancinating in character, and appears in paroxysms. It usually involves the extremities, but sometimes it attacks the stomach and is accompanied with obstinate vomiting. The term gastric crisis is applied to this phenomenon. Crises may occur in other organs, notably the larynx, where they are manifested by intense dyspnoea and stridulous breath- ' ing. Various forms of paresthesia are observed, such as tingling, numbness, " pins and needles," and the like. Irregu- lar areas of anesthesia are frequently distributed aver the body. Reflexes.—The patellar reflex is lost very early in the disease. The pupil fails to respond to light while it still accommodates for distance (Argyll-Robertson pupil). Eye Phenomena.—The most important are diplopia, con- tracted pupils, dimness of vision from optic atrophy, and paresis of the ocular muscles. Trophic Phenomena.—The most curious are the so-called arthropathies, which consist of enlargement of the joints, associated with serous effusions, atrophy of the heads of the bone, erosion of the cartilages, and calcification of the liga- ments. These articular changes sometimes lead to luxations. Perforating ulcer of the foot is sometimes observed. SCLEROSIS OF THE SPINAL CORD. 359 Other symptoms sometimes observed are: loss of sexual power, paralysis of the sphincters, epileptiform seizures, and dementia. Diseases with which locomotor ataxia may be asso- ciated.—Spastic paraplegia, multiple neuritis, paretic demen- tia, and chronic poliomyelitis. Diagnosis. Multiple Neuritis. — In this affection the peripheral nerves are tender; the muscles may yield the reactions of degeneration ; the pain is not lancinating like that of ataxia; and the Argyll-Robertson pupil is absent. Tumor of the Cerebellum.—In this condition the reflexes are not abolished, lightning pains are absent, and instead there are persistent vomiting, headache, and optic neuritis. Gastralgia.—A gastric crisis may be mistaken for gastralgia, but the associated phenomena of locomotor ataxia will prevent an error in diagnosis. Prognosis.—Generally unfavorable, although arrest and even improvement are not infrequent. The duration is in- definite. Treatment.—The patient should be placed under the best hygienic conditions. Rest is desirable. In the early stage a prolonged voyage may produce excellent results. The diet must be nutritious, but easily assimilable. Excesses of all kinds must be rigidly prohibited. Tonics are frequently in- dicated. AVhen there is a suspicion of syphilis, iodide of potassium should be given in full doses. In other cases iodide of potassium in small doses, mercury, and arsenic, are the most reliable remedies. The following pill may prove useful:— fy Sodii arsenat, Zinc, phosphid., aa gr. ij ; Hydrarg. iodid. rub., gr. j.—M. Ft. in pil. !N"o. xxx. Sig.—One, three times daily after meals. Counter-irritation to the spine is useful and may be made with small blisters or the actual cautery. The Pains.—AVhen very intense, morphia will be required ; in other cases antipyrin, phenacetin, and cannabis indica are sometimes efficient. 360 DISEASES OF THE NERVOUS SYSTEM. IJl Antipyrin, §j ; Syr. zingiber., f^j; Aquse q. s. ad fjiv.—M. (Germain See.) Sig.—A teaspoonful every one to four hours for three to six doses. The laryngeal crises may be relieved by the inhalation of chloroform or amyl nitrite. Primary Spastic Paraplegia. (Lateral Sclerosis, Antero-lateral Sclerosis.) Definition.—A nervous affection probably dependent upon sclerosis of the lateral columns, and characterized by loss of power, increased reflexes, and a spastic condition of the muscles. Pathology.—There is probably a sclerosis of the lateral columns of the cord. Symptoms.—Loss of power is generally the first symptom. This begins in the lower extremities and increases very slowly. The knee-jerk is exaggerated, and in most cases ankle-clonus can be elicited. AVhen put in use the muscles become stiff*, or spastic, and when the disease is fully developed the gait is peculiar. In walking the knees are drawn together, the legs drag behind, and the toes catch the ground. The muscles do not waste, but rather tend to become hyper- trophied from continued reflex stimulation. The sphincters are ultimately affected. Sensation is generally undisturbed, but subjective phenomena like numbness and tingling may be observed. The upper extremities are not often involved, but finally loss of power and rigidity may develop in them also. Prognosis.—Unfavorable. In rare instances the disease is arrested. The duration is indefinite. Treatment.—The general treatment is the same as in locomotor ataxia. For the spasmodic condition of the mus- cles, rubbing, warm baths, and the following remedies are recommended: bromide of potassium, calabar bean, and bel- ladonna. SCLEROSIS OF THE SPINAL CORD. 361 Amyotrophic Lateral Sclerosis. Definition.—A nervous affection characterized anatomi- cally by a degeneration of the lateral columns and adjacent gray matter, and manifested clinically by loss of power, wasting, and a spastic condition of the muscles. Pathology.—The disease apparently depends upon a sclerosis involving mainly the anterior horns of the gray matter and the antero-lateral columns. Symptoms.—Loss of power and wasting, usually beginning in the small muscles of the hand, and gradually spreading over the entire body. The reflexes are exaggerated. AVhen the muscles are put into use, they become more or less rigid, or spastic. The degenerative process extends upwards until it involves the medulla, when symptoms of bulbar palsy appear. Diagnosis.—The spasmodic condition of the muscles will distinguish it from pure progressive muscular atrophy. Prognosis.—Unfavorable. Treatment. — Such remedies as arsenic and iodide of potassium are recommended, but they usually prove useless. The spastic condition is improved by massage. Ataxic Paraplegia. Definition.—A sclerotic affection of the posterior and lateral columns manifesting symptoms of both locomotor ataxia and spastic paraplegia. Symptoms.—It resembles spastic paraplegia in the loss of power, spastic condition of the muscles, increased reflexes, and absence of sensory disturbances; and locomotor ataxia in the distinct loss of coordination. Disseminated Cerebro-spinal Sclerosis. (Multiple Sclerosis, Insular Sclerosis.) Definition.—A chronic nervous disease characterized anai tomically by patches of sclerosis of varying size scattered through the brain and cord. Etiology.—The causes which lead to other scleroses of the cord may induce this disease; the infectious fevers, however. 362 diseases of the nervous system. are assigned a prominent place in its etiology. It is more commonly observed in younger people than is locomotor ataxia or lateral sclerosis. Patholgy.—Areas of firm, gray, sclerotic tissue, of various sizes and shapes, are found through the brain and cord. Symptoms.—The spinal symptoms may resemble either locomotor ataxia or lateral sclerosis, according as the posterior or lateral columns are chiefly affected. The characteristic symptoms are loss of power, usually most marked in the legs; increased reflexes; vague pains; a coarse tremor developed on movement (volitional tumor); a slow, hesitating, " scanning" speech ; nystagmus—tremor of the eyeballs; and mental im- pairment. Sensory and trophic disturbances are generally absent. Diagnosis.—Disseminated sclerosis may be mistaken for paralysis agitans, but the latter disease develops in late life; the tremor is fine, rarely involves the head, and is not made worse by use of the muscles; and nystagmus is absent. Prognosis.—Unfavorable. The duration is indefinite, and long remissions with improvement of the symptoms are not uncommon. Treatment.—The general treatment is the same as that for posterior sclerosis. Bromides, hyoscine, hyoscyamine, and belladonna have been recommended for the tremors. Hereditary Ataxia. (Friedreich's Disease.) Definition.—A sclerotic affection of the spinal cord, occur- ring in several children of the same family, and characterized by symptoms resembling locomotor ataxia. Etiology.—The greatest number of cases develop between the second and fifteenth years. Some can be traced to heredi- tary influence; in others a cause cannot be ascertained. Pathology—Sclerosis of the posterior and lateral columns cf the cord. Symptoms.—Loss of coordination • in the arm and legs, nystagmus, irregular jerking movements of the hands, loss of acute anterior poliomyelitis. 363 reflexes, a scanning speech, spinal curvature, equino-varus (heel raised and the sole turned in). It differs from locomotor ataxia in the absence of sharp pains, anesthesia, the Argyll-Robertson pupil, and in the occurrence of irregular movements of the hands, nystagmus, scanning speech, and equino-varus. Prognosis.—Unfavorable. The duration is many years. SYRINGO-MYELIA. Definition.—A cavernous coudition of the gray matter of the spinal cord associated with an overgrowth of the neuroglia and more or less degeneration of the surrounding tissue. Etiology.—The disease is probably of congenital origin, although it may not manifest itself until adult life. Symptoms.—Paralysis and wasting of the muscles, especially of the upper extremities; spinal curvature; a loss of painful and thermic sensation, while tactile sensation is preserved, are the chief phenomena. Symptoms of lateral or of posterior sclerosis are generally present. Diagnosis. Chronic Poliomyelitis.—In this affection there are no sensory disturbances. Morvan's Disease,—This disease closely resembles syringo- myelia, but tactile sensation is lost and there is a marked tendency to painless whitlows. Prognosis.—Unfavorable. Duration, six months to several years. ACUTE ANTERIOR POLIOMYELITIS. (Infantile Paralysis, Atrophic Spinal Paralysis.) Definition. — An acute disease, occurring almost exclu- sively in young children, characterized anatomically by a de- struction of the ganglion-cells in the anterior gray horns of the cord, and manifested clinically by abrupt paralysis and rapid wasting of certain muscles. Etiology. — The greatest number of cases occur within the first three years, and the disease is far more common in summer than in winter. The sudden onset, the absence of 364 DISEASES OF THE NERVOUS SYSTEM. any known exciting cause, and the fact that it has occurred epidemically suggest an infectious origin. Pathology. — The sudden onset and wide-spread initial paralysis are probably due to intense congestion, and the per- manent paralysis and wasting to destruction of the ganglion- cells in the anterior gray horns. Microscopic examination in recent cases reveals ecchymoses, destruction of ganglion-cells, and infiltration of leucocytes. Examination long after the development of the paralysis reveals an absence or atrophy of the large multipolar cells in the gray horns, and in their stead an overgrowth of connec- tive tissue. The anterior nerve-roots and muscles also reveal degenerative changes. Symptoms.—Generally the onset is abrupt; often the child is put to bed in apparent health and in the morning is found paralyzed in one or more limbs. In some cases febrile symp- toms precede the attack, and more rarely the disease is ushered in with a chill, a convulsion, or delirium. The paralysis at first may be quite extensive, but more com- monly it confines itself to certain groups of muscles in the upper and lower extremities. The latter are especially prone to suffer; the affected muscles are relaxed, and the surface is cold and often cyanosed. The paralysis is peculiar in its irregular distribution and in its tendency to improve spontaneously up to a certain limit. There are no sensory disturbances, no involve- ment of the bladder and rectum, and no tendency to bedsores. The muscles which are permanently affected rapidly waste and yield the reactions of degeneration. From contractures of the atrophied muscles and contraction of their healthy antagonists, various deformities develop. Diagnosis.—The abrupt onset will distinguish it from both idiopathic muscular atrophy and progressive muscular atrophy. The absence of sensory disturbances, bedsores, and paralysis of the bladder and rectum will separate it from myelitis. The presence of cerebral symptoms, of choreiform or athetoid movements in the affected members, and the absence of reac- tions of degeneration and of early wasting will separate cere- bral paralysis of childhood from acute poliomyelitis. PROGRESSIVE MUSCULAR ATROPHY. 365 Prognosis.—Unless the initial symptoms are very severe, the prognosis, as regards life, is good. In all cases some of the paralysis disappears. Occasionally the improvement is so great that the usefulness of the member is not impaired ; but far more frequently the residual paralysis is sufficient to cause considerable deformity and disability. Treatment.—During the acute stage the child should be confined to bed. To relieve the congestion, dry cups may be applied to the spine and ergot may be given internally. The affected members should be wrapped in flannel. After the lapse of two or three weeks electrical treatment should be instituted; the faradic current may be employed when it induces contraction of the affected muscles, but when it excites no response the galvanic current must be substituted. Massage is a very valuable adjunct to the electrical treatment. Internally strychnia (gr. T^n to a child of two years) gradually increased is a useful muscular stimulant. Massage and the adjustment of mechanical appliances will be required to combat deformity from contractures. PROGRESSIVE MUSCULAR ATROPHY. (Chronic Spinal Muscular Atrophy, Chronic Poliomyelitis.) Definition.—A chronic nervous affection, characterized anatomically by degeneration of the ganglion-cells of the gray matter in the cord, and manifested clinically by loss of power and atrophy of corresponding muscles. Etiology.—Male sex, middle life, and hereditary tendency are the predisposing causes. It sometimes follow prolonged emotional excitement, exposure to cold, traumatism, and syphilis. Pathology.—Microscopic examination of the gray matter of the cord reveals atrophy or complete absence of the large multipolar cells in the anterior cornua, and an overgrowth of connective tissue. The anterior root-fibres are also the seat of degenerative changes. In some cases the lateral columns are likewise sclerosed (amyotrophic lateral sclerosis). Examination of the affected muscles reveals atrophy of the fibres, fatty degeneration, an overgrowth of connective tissue, 366 DISEASES OF THE NERVOUS SYSTEM. and an absence of transverse striation, and instead, longitudi- nal striation. Symptoms.—Not infrequently prodromal symptoms are noted in the parts to be affected, such as pam, coldness, or numbness. Soon, loss of power and wasting begin in the small muscles of the hand, namely, the thenar and interossei muscles. Although one hand is usually affected before the other, the disease tends to become symmetrical. Next to the hands the muscles of the shoulders and arms slowly waste, ren- dering the bony prominences marked ; and so the disease advances little by little until the patient is reduced to a mere skeleton. The hands assume a characteristic appearance : from atrophy of the interossei and contraction of the long extensor and flexor muscles they become " claw-like." The wasted mus- cles are frequently the seat of fibillary tremors. The response to the galvanic and faradic currents is diminished, but the re- actions of degeneration do not develop until the disease is far advanced. Although the patient may complain of coldness and numbness, sensation is not impaired. The legs are not involved until late, and often escape entirely. The wasting progresses very slowly, and death may result from some intercurrent disease; if such is not the case, exten- sion to the medulla leads to symptoms of bulbar palsy, such as indistinct articulation, inability to pucker the lips, difficult swallowing, and embarrassed respiration. Complications.—It may be associated with lateral sclerosis, when it is termed amyotrophic lateral sclerosis. It may lead to bulbar palsy. Diagnosis. Primary Muscular Atrophy.—This disease develops in earlier life, rarely begins in the hand, and the hereditary tendency is more marked than in poliomyelitis. Prognosis.—Always unfavorable. The duration is indefi- nite. Treatment.—Good hygiene. Nutritious food. Tonics. Gowers claims good results from the hypodermic injection of nitrate of strychnia (gr. ^\-§ increased to -fa) once daily. Massage and electricity yield no results. ACUTE ASCENDING PARALYSIS. 367 BULBAR PARALYSIS. (Glosso -labio-laryngeal Paralysis.) Definition.—Paralysis of the lips, tongue, pharynx, and larynx from destruction of the ganglionic cells of the" medulla oblongata. Etiology.—An acute form is observed which results either from hemorrhage or from an acute poliomyelitis of the medulla. The chronic form, or progressive bulbar palsy, may result from chronic poliomyelitis involving primarily the medulla, or from the extension of the degenerative process in paretic dementia, amyotrophic lateral sclerosis, progressive muscular atrophy, or acute ascending paralysis (Landry's disease). Symptoms.—Impairment of speech; inability to protrude the tongue; dribbling of saliva; difficult swallowing; choking spells from the entrance of food or mucus into the larynx; partial suppression of the voice and measured speaking; fibrillary tremors of the lips and tongue; loss of reflex action ; atrophy of the lips, tongue, and pharynx ; and, finally, difficult respiration and disturbed cardiac rhythm. Prognosis.—Unfavorable. The acute variety is speedily fatal; the chronic form may last several years. Death may result from exhaustion, cardiac failure, or aspiration-pneu- monia. Treatment. — Electricity, strychnia, and the use of a stomach-tube when swallowing becomes difficult. ACUTE ASCENDING PARALYSIS. (Landry's Disease.) Definition.—An acute disease of rare occurrence, char- acterized by motor paralysis, beginning in the feet and rapidly spreading until it involves the muscles of respiration and deg- lutition. Etiology.—The causes are unknown. It is usually ob- served in young male adults. The abrupt onset, acute course, and absence of known cause and of definite lesions have sug- gested an infectious origin. 368 DISEASES OF THE NERVOUS SYSTEM. Pathology.—No demonstrable lesions have been discovered. Symptoms.—Febrile symptoms usually usher in the attack. The paralysis begins in the legs and involves successively the trunk, upper extremities, and muscles of respiration and deg- lutition. The reflexes are abolished. The sphincters are retentive; sensation is usually normal, but there may be paresthesia or some anesthesia; the muscles are relaxed, but do not waste or yield the reactions of degeneration. In some instances the spleen and lymphatic glands are swollen. Diagnosis. Acute Myelitis.—Anesthesia, wasting, reactions of degeneration, and early involvement of the sphincters will serve to distinguish myelitis from acute ascending paralysis. Multiple neuritis will be separated from Landry's disease by the marked sensory disturbances in the former. Prognosis.—Unfavorable. The vast majority of cases ter- minate fatally in the course of a few days. Occasionally there is a spontaneous arrest, and a gradual restoration to health. Treatment.—Cups to the spine and electricity to the affected muscles have been employed with indifferent results. CAISSON DISEASE. (Divers' Paralysis.) Definition.—A condition observed in divers and others subjected to increased atmospheric pressure, and characterized by motor and sensory paralysis, particularly of the lower ex- tremities. Etiology.—A pressure of more than two atmospheres is required to produce the paralysis ; and the time elapsing before its appearance lessens as the pressure increases. Pathology.—The symptoms have been ascribed to the liberation in the nerve-centres of gases which have been absorbed by the blood during exposure to the high pressure. Ecchymoses and irregular fissures have been discovered in the cord. Symptoms.—The condition may manifest itself immediately on reaching the surface or after the lapse of several hours. The most important phenomena are pains in the joints fol- lowed by motor and sensory paralysis in the lower extremities. IDIOPATHIC MUSCULAR ATROPHY. 369 The bladder and rectum are sometimes involved. Occasion- ally the paralysis takes the form of a hemiplegia instead of a paraplegia. In severe cases coma develops and death follows in a few hours. Generally, however, the symptoms gradually subside and the power is fully restored in the course of a few days or a few weeks. Treatment.—As a preventive measure the transition from high to low pressure should be accomplished gradually. Marked cases should be treated as acute myelitis. IDIOPATHIC MUSCULAR ATROPHY. (Muscular Dystrophy, Myopathic Atrophy.) Definition.—Au atrophic condition of the muscles de- veloping in early life and not dependent upon any lesion in the nervous system. Etiology.—The disease usually manifests itself before puberty. It is more common in males than in females. It is frequently transmitted from generation to generation, and several members of the same family may be similarly affected. Pathology.—No lesion in the cord or nerves is observed. Gowers regards the disease as of developmental origin. Micro- scopic examination of the muscles reveals atrophy of their fibres and an unnatural amount of fat and connective tissue. AVhen the latter elements are considerably increased, a pseudo-hyper- trophy results (pseudo-muscular hypertrophy). Symptoms.—The muscles, especially those of the face, shoulders, thighs, buttocks, and calves, lose power and waste. Fibrillary twitchings are sometimes noted. The reactions of degeneration are present. Diagnosis. Chronic Poliomyelitis.—This disease develops later in life without marked hereditary tendency, and nearly always begins in the small muscles of the hands—parts which are rarely affected in idiopathic atrophy. Multiple Neuritis.—The history, distribution of the palsy, and the sensory phenomena will serve to distinguish multiple neuritis. Prognosis.—Unfavorable. The disease is incurable, but of slow progress. 370 DISEASES of the nervous system. PSEUDOHYPERTROPHIC PARALYSIS. (Pseudo-muscular Hypertrophy, Lipomatous Muscular Atrophy.) Definition.—A disease of childhood, characterized by paralysis depending upon degeneration of the muscles, which, however, become enlarged from a deposition of fat and con- nective tissue. Etiology.—Male sex, childhood, and an hereditary tend- ency are the only known predisposing causes. Several cases have frequently been observed in the same family. Pathology.—The disease is allied to idiopathic muscular atrophy, with which it is frequently associated. Since no lesions are observed in the cord or peripheral nerves it is to be regarded as a primary affection of the muscles. Microscopic examination reveals an excessive amount of fat and connective tissue between the muscle-fibres, the latter being atrophied and more or less degenerated. Symptoms.—The first symptom to attract attention is weak- ness of the muscles; the child is awkward, stumbles, and in walking seeks support. As the paralysis increases, the mus- cles, particularly ihose of the calf, thigh, buttock, and back, enlarge. The upper extremities are less frequently affected. When the child assumes the erect posture the feet are wide apart, the belly protrudes, and the spinal column shows a marked curvature with the convexity forward. The manner of rising from the recumbent position is characteristic: He straightens himself either by grasping the knees, or by resting the hands on the floor in front him, extending the legs, and pushing the body backwards. Although the response of the muscles to electrical currents is less pronounced, the reactions of degeneration are not present. The knee-jerk is lessened or abolished. There are no mental or sensory disturbances. In the course of a few years, the paralysis becomes so marked that the patient is unable to leave his bed; the enlargement of the muscles is followed by atrophy; and finally death results from some intercurrent disease, or inflammation of the lungs induced by the weakened respiratory power. NEURALGIA. 371 Prognosis.—Absolutely unfavorable. Treatment.—Remedies generally prove useless. Graduated exercise, massage, electricity, and hypodermics of strychnia may be employed with the hope of staying the progress of the disease. NEURALGIA. Definition.—Paroxysmal pain radiating along the course of a nerve-trunk. Etiology.—Heredity, female sex, nervous temperament, excesses, overwork, and nervous exhaustion are general pre- disposing factors. It is frequently an expression of anemia. It may result from the action of some toxic agent in the blood ; thus it is common in malaria, rheumatism, gout, syphilis, and chronic lead-poisoning. It may be caused by reflex irritation; thus a trifacial neuralgia may depend on caries of the teeth or eye-strain. In some cases neuralgia results from organic dis- ease of the nerve-centre; thus obstinate trifacial neuralgia may be dependent upon some degeneration or tumor of the Gasserian ganglion. Exposure to cold and wet frequently acts as an exciting cause in susceptible people. Pathology.—The pathological condition upon wrhich neu- ralgia depends is unknown. In many cases, no doubt, it is a manifestation of neuritis. Symptoms.—Certain prodromes frequently give warning of an approaching attack ; these are chilliness, depression of spirits, and perhaps tingling in the part to be affected. The chief symptom is intense pain, which is usually of a sharp, stabbing character. The area supplied by the affected nerve is gener- ally hyperesthetic, and palpation detects spots of exquisite tenderness where the nerve makes its exit through a bony canal or fibrous sheath; the latter have been termed Val Hex's points- In some cases the pain is attended with severe clonic or tonic spasms of the muscles. Inspection of the part usually reveals negative results, but occasionally distinct swelling or an outbreak of herpes is observed. The attack lasts from a few minutes to many hours, and its 372 DISEASES OF THE NERVOUS SYSTEM. subsidence may be marked by the passage of a large amount of pale urine. The interval between the paroxysms varies in different cases; it is frequently several weeks or months. It is noteworthy that the attacks often recur at regular intervals. Trifacial Neuralgia (Tic Douloureux, Prosopalgia)—In this variety the pain involves one or more branches of the trifacial nerve. The tender points correspond to the supra-orbital, infra-orbital, and mental foramina. \riolent spasms of the muscles are frequently observed. In long-standing cases the hair on the affected side may become coarse and bleached. Trifacial neuralgia is frequently reflex, being dependent upon caries of the teeth, eye-strain, nasal disease, or some distant centre of irritation. Intercostal Neuralgia.—In this variety the pain follows the course of the intercostal nerves. It is frequently associated with an eruption of herpes zoster. Spots of tenderness may be detected near the vertebral columns, in the middle of the nerve, and near the sternum. The frequent dependence of intercostal neuralgia upon spinal caries or thoracic aneurism must not be forgotten. Occipital neuralgia involves the upper cervical nerves. A spot of tenderness may be discovered midway between the mastoid process and the upper cervical vertebrae. This form of neuralgia may be an expression of spinal caries. Sciatica has been described elsewhere. Diagnosis. Neuritis.—The continuous pain, the tender- ness along the entire nerve, the presence of paresthesia, anes- thesia, paresis, and wasting will serve to distinguish neuritis from neuralgia. The lightning-pains of locomotor ataxia must not be mis- taken for neuralgia. The abolished patellar reflex, the loss of coordination, and the Argyll-Robertson pupil in the former will indicate the diagnosis. Prognosis.—For the attack the prognosis is good ; for per- manent cure, it must be guarded. AVhen the cause can be removed the prognosis is favorable. Treatment. The Attack.—The patient should be kept in a quiet, cool, well-ventilated room. Local applications are useful; hot cloths, stimulating liniments, an ointment of NEURALGIA. 373 aconitia, a small blister, or a hypodermic injection of cocaine, chloroform, or morphia and atropia may be employed. One of the following applications will prove serviceable :— $. Aconitinse, gr. iv; Veratrinse, gr. xv; Glycerini, 3'j ; Cerati, 3yj.—M. (Da Costa.) Sig.—To be rubbed over the parts. Do not apply to any abrasion of the skin. Or— tyi Chloral, hydrat., Pulv. camphor., aa ^ss.—M. Sig.—Apply with a camel's hair brush. Internally, antipyrin, phenacetin, cannabis indica, bromide of potassium, butyl chloral, and exalgine are efficient remedies. Morphia is sometimes required, but the danger of inducing the habit should always be borne in mind. Ihe Interval.—Careful search should be made for an exciting cause, which, if found, must be removed. The teeth, eyes, nose, gastro-intestinal tract, urine, and blood should be care- fully examined. In anemia, iron and arsenic are indicated; in syphilis, iodide of potassium ; in rheumatism, salicylate of sodium or iodide of potassium ; in malaria, quinine and arsenic; in gout colchicum and lithium ; in lead-poisoning, iodide of potassium. Tonics like iron, quinine, strychnia, cod-liver oil, and phos- phorus are frequently indicated. Among the special reme- dies may be mentioned arsenic, velerian, hyoscyamus, aconitia, gelsemium, cannabis indica, oxide of zinc, nitro-glycerin, and asafoetida. The following pill, devised by Dr. S. D. Gross, is often very useful :— ]£. Quinin. sulph., 3j Morphin. sulph., Acid, arsenosi, aa gr. iss ; Ext. aconiti, gr. xv ; Strychnin, sulph., gr. j.—M. Ft. in pil. No. xxx. Sig.—One, thrice daily. Local treatment in the interval may accomplish much. Electricity, acupuncture, or repeated blisters may be employed. 374 DISEASES of THE nervous system. In obstinate cases surgical interference may be required to secure relief. Threeoperations have been performed : Nerve- stretching ; neurotomy, or section of the nerve; and neurec- tomy, or removal of a portion of the nerve. MIGRAINE. (Hemicrania, Megrim, Sick-headache.) Definition. — Paroxysmal circumscribed headache asso- ciated with visual, vaso-motor, and gastric disturbances. Etiology.—It is frequently hereditary. It is more com- mon in women than in men. It usually develops in early life. Anemia, gastric disturbances, eye-strain, menstrual disorders, overwork, and prolonged emotional excitement predispose to it. Pathology.—Unknown. There is a growing tendency to regard it as a sensory epilepsy. Symptoms.—The attack is often preceded by malaise, rest- lessness, and diminished vision. The pain is sharp and stabbing and frequently limited to the temporo-frontal region of one side. The surface is extremely hyperesthetic, but the tender spots noted in trifacial neuralgia are absent. The patient is very sensitive to light and sound, and during the attack usually confines herself to a darkened room. Nausea and vomiting are frequently present. In some cases the tem- poral artery is contracted, the face is pale, and the pupil large ; in others the artery is dilated, the face is flushed, and the pupil small. The duration of the attacks varies from a few hours to several days. In the intervals, which are often of definite duration, the patient may be quite well. Less frequent symptoms are vertigo, hallucinations of sight, cramps of the facial muscles, tingling or numbness in one hand, partial aphasia, and paresis of the ocular muscles. Prognosis.—Perfect cure is rare, but the severity and fre- quency of the seizures may be considerably lessened by treat- ment. Treatment. The Attack,—Rest in a darkened, quiet, and well-ventilated room ; antipyrin, caffeine, bromide of potas- sium, salol, and morphia with atropia are useful remedies. headache. 375 ty. Antipyrin, &j; Syr. aurant. cort., f|j ; Aque, q. s. ad f.^iij.—M. Sig.—A tablespoonful every two hours. Or— ty. Caffein. citrat., gr. xij ; Phenacetin, gr. xviij ; Sodii bromid., 3j.— M. Ft. in chart. No. vi. Sig.—One powder every hour. Or— $ Salol, 3j; CafFein. citrat., Phenacetin, aagr. xviij.—M. Ft. in chart. No. vi. Sig.—One every two hours. The Interred.—Careful search should be made for some ex- citing cause, and when found, removed if possible. The habits of the patient must be regulated. Overwork and the use of alcohol, strong tea and coffee must be interdicted. Systematic exercise and frequent bathing followed by friction are valuable adjuncts. The diet must be adapted to the condition of the stomach and the needs of the system. Internally, arsenic, iodide of potassium, bromide of potassium, valerianate of zinc, and cannabis indica are the most reliable remedies. Cannabis indica is often very efficient, and a quarter to half a grain of the extract may be given for a prolonged period. Little recommends :— ]£. Sodii arsenat., gr. ij ; Ext. cannabis indicae, gr. iv ; Ext. belladonna?, gr. viij.—M. Ft. in pil. No. xxiv. Sig.—One, twice daily. HEADACHE. (Cephalalgia.) Definition.—Pain in the head generally resulting from a disturbance of the cerebral circulation, a perverted condition of the blood, reflex irritation, or pressure on the brain by in- flammatory exudate, depressed bone, or a tumor. 376 DISEASES OF THE NERVOUS SYSTEM. Organic Headache.—This form is observed in meningitis, cerebral tumor, abscess, softening, etc., and may be recognized by its persistence and by the associated evidences of organic cerebral disease, such as optic neuritis, mental aberration, paralysis, especially of the facial muscles, and vomiting arising independently of other gastric symptoms. Under this head is included the headache of syphilis, which may be diagnosed by the history ; by the other evidences of syphilis; by its frequent association with somnolence ; and by the effect of iodide of potassium. Headache of Cerebral Hyperaemia.—Active cerebral con- gestion usually results from prolonged mental work, fever, or exposure to the sun. Toxic and reflex headaches are often directly due to active cerebral congestion, but these will be discussed later. Passive cerebral congestion may result from obstruction to the return of blood from the brain, as by a tumor of the neck, or cardiac disease. It is also common in elderly people from a relaxed condition of the vessels. In cerebral congestion the headache is of a throbbing or bursting character; the head is hot; the face flushed; the eye-ground injected ; and the distress is increased by lowering the head. The exciting cause must be determined by the history and by a careful examination of the various organs, especially the heart. Headache of Cerebral Anaemia.—This is frequently de- pendent upon general anemia. It is also common in neuras- thenia resulting from overwork, prolonged emotional excite- ment, excesses, etc. More rarely it is dependent upon aortic stenosis. In cerebral anemia the pain is frequently vertical; it is not throbbing, but it is described as a sensation of weight or gnaw- ing ; the extremities are cold ; the face and eye-grounds are pale ; the mind is depressed ; fainting spells are often present; lowering the head and the inhalation of nitrite of amyl relieve the pain. Reflex Headache.—Headache is often due to eye-strain re- sulting from refraction errors, and in obstinate cases a careful HEADACHE. 377 examination of the eyes should always be made. Headache of this origin is frequently a browache, and may be associated with restlessness, vomiting, and insomnia. It is induced or aggravated by prolonged use of the eyes. Ovarian or uterine diseases often produce a reflex headache. It is usually located at the vertex, and is relieved by pressure of the hand. Gastric irritation is responsible for many headaches; the latter are invariably relieved by vomiting, and are usually associated with other evidences of stomachic disorder. Nasal catarrh may induce persistent headache, which is generally confined to the forehead, temples, or vertex, and is aggravated by exacerbations of the catarrah. The pain is often associated with tenderness of the inner wall of the orbit, and is increased by irritating the nasal mucous membrane with a probe. Toxaemic Headache.—A persistent headache often results from Bright's disease, and is uraemic in origin. It may be recognized by the high arterial tension and by the albumin and casts in the urine. A urinary analysis should be made in all cases of persistent headache. Gout or lithoemia produces an intractable headache which is associated with vertigo, great irritability of temper, and a "brick-dust" deposit in the urine. Chronic malarial poisoning may manifest itself in a head- ache which is usually confined to the supraorbital region. It is apt to recur at regular intervals, is often associated with tenderness over the supraorbital nerve, and is only relieved by large doses of quinine. A headache of rheumatic origin sometimes develops in those subject to rheumatism. It is frequently excited by exposure or a sudden change of temperature. It usually affects the aponeurosis of the occipito-frontalis and temporal muscles, is increased by wrinkling the forehead and forcibly moving the jaws, and is associated with tenderness of the scalp. Alcoholism is often associated with headache. In acute alcoholism, the headache probably results from cerebral hyper- emia ; in chronic alcoholism it is often due to a low grade of meningitis. 378 DISEASES OF THE NERVOUS SYSTEM. Among other headaches of toxic origin may be mentioned those due to constipation, lead-poisoning, diabetes, infectious fevers, and absorption of foul gases. Hysterical Headache.—In hysteria there is often a per- sistent headache, which grows worse at the menstrual periods, and which improves under pleasurable excitement. It may be diffuse, but frequently it is localized, and is described as resembling the effect which would be produced by a nail being driven into the head; hence it has been termed clavus. Diagnosis.—Headache must be distinguished from mi- graine. In the latter there are usually prodromal symptoms, disturbances of vision, pupillary changes, and the pain is fre- quently confined to one side of the head. Headache in the region of the orbit may be mistaken for acute glaucoma, but in the latter condition the eye is inflamed; the cornea is hazy; the pupil is sluggish ; vision is impaired ; and on palpation the affected eyeball is found to be harder than its fellow. Treatment.—In the interval between the attacks careful search should be made for the cause, which, if possible, must be removed. In the reflex headache of eye-strain the ad- justment of proper glasses is often all that is required. In gastric headache, the associated catarrh of the stomach must be treated by a light diet and the use of such remedies as bismuth and nitrate of silver. In the headache of anemia, a nutritious diet, with iron, arsenic, and other tonics will be required. In headaches of uremic origin, a milk diet with measures cal- culated to increase the action of the skin, bowels, and kidneys, will often afford considerable relief. In malarial headache quinine in large doses with arsenic will effect a cure. The Attack.—In headache dependent upon gastric acidity, after unloading the stomach with a non-irritating emetic, bromides with antacids will prove useful, thus :— I£ Sodii bromid., 313; Spt. amnion, aromat., fgij ; Aque q. s. ad f^iij.—M. Sig.—A tablespoonful every hour or two. In headache of acute cerebral congestion the feet should be soaked for ten or fifteen minutes in very hot water; an ice- neuritis. 379 bag placed on the head ; and some sedative like the following administered :— $: Phenacetin, jj ; Sodii bromid., ^ss.—Al. Ft. in chart No. xii. Sig.—One powder every hour or two until relieved. AVhen the attack is very severe, aconite (gtt. j-ij) may be given every hour or two. In cerebral anemia good temporarily follows the use of antipyrin or phenacetin, especially in combination with caffeine, thus :— fy Phenacetin, gj ; Caffein. citrat., gr. xxiv.—M. Ft. in chart No. xii. Sig.—One as required. In rheumatic headache salol is very useful; it may be com- bined with antipyrin :— fy Salol, gss; Antipyrin, 3J.—M. Ft. in chart No. x. Sig.—One every hour or two until relieved. In uremic headache the diet should be restricted to milk, action of the bowels secured by a saline draught, and diuresis encouraged by digitalis, caffeine, or the vegetable salts of po- tassium :— IJ. Potass, citrat., gij ; Spt. juniperi, fgvj ; iEther. nitros., f,5ij ; Infus. scoparii, fjvj.—M. (Day.) A wineglassful, thrice daily. NEURITIS. Definition.—Inflammation of nerves. Etiology.—(1) It may result from traumatism—blows, wounds, or compression. (2) It may be due to exposure to cold and wet. (3) It may be secondary to inflammation of adjacent structures. (4) It may be secondary to rheumatism, gout, syphilis, or one of the infectious fevers. 380 DISEASES OF THE NERVOUS SYSTEM. Pathology.—The sheath, interstitial connective tissue, or fibres may be independently affected, but as a rule, all parts of the nerve are involved. AVhen the process is acute the nerve is red and swollen, and microscopic examination reveals an infiltration of leucocytes, with more or less granular degenera- tion of the fibres. In chronic neuritis the nerve-trunk is gray, shrivelled, and hard, and microscopic examination shows an overgrowth of connective-tissue and granular degeneration of fibres. Symptoms of Acute Neuritis.—There are three sets of phenomena—sensory, motor, and trophic. Sensory Symptoms. — There is severe pain following the course of the affected nerve, which is tender to the touch. The pain is often associated with various manifestations of pares- thesia, such as burning, numbness, tingling, and the like. The part is at first hyperesthetic, but later it is more or less anes- thetic. Motor Symptoms.—Muscular power is impaired ; there may be fibrillar tremors; and the reflexes are diminished or lost. Trophic Symptoms.—An eruption of herpes sometimes fol- lows the affected nerves. The skin may become glossy and the nails lustreless and brittle. In advanced cases there are wasting of muscles and impaired electro-contractility. Occa- sionally effusion into the joints is observed. In some cases there may be febrile symptoms. Chronic neuritis is characterized by pain, anesthesia, paresis, atrophy and contracture of the muscles, reactions of degen- eration, " glossy skin," and thickening and brittleness of the nails. Diagnosis.—Neuritis may be mistaken for neuralgia ; but in the latter the pain is paroxysmal and is unassociated with tenderness along the course of the nerve, paresthesia, anes- thesia, paresis, and changes in the electro-contractility. Prognosis.—In acute cases the prognosis is guardedly favorable; the duration is from a few days to several weeks. In chronic neuritis, after the development of marked trophic changes, the prognosis is grave. Treatment.—The cause should be ascertained and, if pos- sible, removed. In rheumatism, alkalies and salicylates are MULTIPLE neuritis. 381 indicated. In syphilis, iodide of potassium should be admin- istered in large doses. The part should be put at rest. For the pain, sedative lotions (lead-water and laudanum), warm fomentations, or small blisters may be applied to the affected parts, and morphia administered hypodermically. When morphia is contra-indicated, salicylate of sodium or phenacetin may be employed in its stead. After the sub- sidence of acute symptoms, iodide of potassium may be given for its absorbent effect and small blisters applied locally. Restoration of power will be assisted by massage and elec- tricity, and by the administration of strychnia, internally or hypodermically. MULTIPLE 1VEURITIS. Definition.—Inflammation of several nerve-trunks, re- sulting from a general cause, and characterized by pain, paresthesia, anesthesia, paresis, and muscular atrophy. Etiology.—Alcoholism, syphilis, rheumatism, the infec- tious fevers, exposure to cold and wet, and mineral poisoning are common causes. In the Orient, multiple neuritis occurs as an endemic disease (Kakke or Beri-beri), which is probably microbic in origin. Symptoms.—The acute form is characterized by a chill fol- lowed by moderate fever (102°-103°), headache, pain in the back, malaise, coated tongue, loss of appetite, constipation, febrile urine, and the following local phenomena: Pain, numb- ness, and tingling in the affected limbs; loss of power, espe- cially in the legs and extensor muscles; abolition of the reflexes; atrophy of the muscles; more or less anesthesia; and tenderness over the nerve-trunks. Chronic Form.—Febrile symptoms are absent and the dis- ease is manifested by pains in the limbs, hyperesthesia, pares- thesia, irregular areas of anesthesia, loss of power, abolition of the deep reflexes, tenderness over the nerve-trunks, wasting of the muscles, impaired electrical contractility, and oedema of the hands and feet. Complications.—Delirium, delusions, and hallucinations are not uncommon, especially in the alcoholic variety. The disease is sometimes associated with locomotor ataxia. 382 diseases of the nervous system. Diagnosis. Locomotor Ataxia.—The absence of the light- ning-pains, girdle sensation, Argyll-Robertson pupil, and the presence of paralysis, wasting, and neural tenderness will serve to distinguish multiple neuritis from locomotor ataxia. Prognosis.—Guardedly favorable. Acute neuritis some- times proves fatal from involvement of the respiratory mus- cles. In chronic cases of long duration the outlook is not hopeful. Treatment.—Acute cases should be kept at absolute rest. For the relief of pain hot fomentations, lead-water and lauda- num, and rubefacient liniments may he applied to the affected limbs; and morphia, antipyrin, phenacetin, or salicylic acid administered internally. After acute symptoms have sub- sided, massage, electricity, and Swedish movements should be employed to secure a return of power. An ointment of mercury and belladonna may be used for its absorbent and anodyne effect. Strychnia hypodermically is an invaluable muscular tonic. Rigidity is best relieved by manipulation and the frequent use of warm baths. In syphilitic cases em- ploy mercurial inunctions and iodide of potassium. SCIATICA. Definition.—Pain along the sciatic nerve, usually resulting from neuritis. Etiology.—Male sex, middle life, gout, rheumatism, and syphilis are predisposing causes. Exposure to cold and wet is the common exciting cause. Very rarely sciatica is a sec- ondary condition resulting from the presence of an intra-pelvic growth or from caries of the bone in joint disease. Symptoms.—The disease may begin abruptly or gradually, and is characterized by a sharp shooting pain running down the back of the thigh. Movement of the limb intensifies the suffering. The pain may be uniformly distributed along the course of the nerve, but not infrequently there are certain spots where it is more intense. Subjective sensations, such as tingling and numbness, are often noted. The nerve may be extremely sensitive to touch. The symptoms grow worse at night and on the approach of stormy weather. The dura- FACIAL PARALYSIS. 383 tion of the attack varies from a few days to several months. In long-standing cages the muscles become atrophied and rigid. Diagnosis. Coxalgia.—In this affection the pain is most marked in the hip- and knee-joints; pressure over the tro- chanter elicits pain ; and the nerve is not tender to the touch. Prognosis.—Recovery follows in the majority of cases when treatment is instituted early and is persistently carried out. In some cases relapses occur frequently, and finally the pain becomes more or less continuous. Treatment.—In the acute stage rest is essential. Hot fomentations or linear blisters may be applied along the course of the nerve. Deep injections of morphia, antipyrin, or cocaine may be required to relieve the pain. In rheumatic cases full doses of the salicylate of sodium are very useful. In chronic cases prolonged rest is desirable. Counter-irritation should be made by frequent small blisters, by the actual cautery, or by acupuncture. Deep injections along the course of the nerve give much relief, and one of the following remedies may be so employed : morphia and atropia, cocaine, antipyrin, or plain water. Electricity sometimes does good. Internally iodide of potassium in small doses is useful; in syphilitic cases it should be given in large doses. The following com- bination is also efficient:— J$l Tinct. aconiti rad., Tinct. colchici sem., Tinct. belladonna?, Tinct. cimicifugae, aa f^ij.—M. (Metcalf.) Sig.—Twelve drops every four to eight hours. FACIAL PARALYSIS. (Bell's Palsy.) Etiology.—Paralysis of one side of the face may result: (1) From a tumor, clot or abscess involving the facial centre on the cortex of the brain or the nucleus of the facial nerve; (2) from the pressure of inflammatory exudate on the nerve- trunk between the brain and the skull; (3) from paralysis of the nerve within the petrous portion of the temporal bone, excited by a fracture, or by an extension of inflammation of 384 DISEASES OF THE NERVOUS SYSTEM. the middle ear; (4) from inflammation of the peripheral fila- ments, excited by exposure, injury, rheumatism, or one of the infectious fevers. Symptoms.—The side affected is expressionless ; the natural lines are obliterated ; the angle of the mouth droops; the eye cannot be closed ; tears flow over the cheek ; and speech is affected from an inability to pronounce the labials. AVhen the patient attempts to laugh or whistle, the absence of move- ment on the affected side beeomes still more conspicuous. In peripheral neuritis the reflexes are abolished ; and when the nerve is involved in the temporal bone there may be a loss of taste in the anterior part of the tongue. Diagnosis.—AVhen the lesion is in the brain the paralysis is rarely complete, the upper part of the face usually escaping; neighboring cranial nerves are frequently affected; and other evidences of organic brain disease are generally present. AVhen the nerve is involved within the Fallopian canal there is often a loss of taste in the anterior part of the tongue, and some disturbance of hearing—deafness or perhaps hyper- sensitiveness to sound. In peripheral neuritis the history, the completeness of the paralysis, and the absence of reflexes will assist in the recog- nition of the lesion. Prognosis.—The prognosis will vary with the cause. It should be guardedly favorable when the paralysis is due to peripheral neuritis. Treatment.—The cause should be ascertained, and if pos- sible, removed. In paralysis of centric origin little can be done, except in syphilitic cases, In middle-ear disease reme- dies should be directed to that organ. AVhen paralysis results from inflammation of the peripheral filaments of the facial nerve, blisters should be applied near the stylo-mastoid fora- men, and as it often appears to be an expression of rheumatism, salicylates may be given internally. Later, a course of iodide of potassium will be useful, and restoration of power may be materially assisted by massage, electricity, and local injections of strychnia. EPILEPSY. 385 EPILEPSY. (Idiopathic Epilepsy, Falling Sickness.) Definition.—A chronic disease of the nervous system, characterized by paroxysms of unconsciousness which are usually associated with general convulsions. Etiology.—Heredity predisposes, and the ancestral disease may not have been epilepsy but insanity, hysteria, or another neurosis. It generally begins before puberty, and very rarely after the twenty-fifth year. All causes which impair the health and exhaust the nervous system exert a predisposing influence. The reflex convulsions of children resulting from gastric irritation, worms, etc., if long continued may induce chronic epilepsy. In these cases, although the exciting cause has been removed, the habit of spontaneous motor discharge, through constant repetition, is established, and may continue through life. In those subject to convulsions, overwork, gas- tric irritation, or excitement may precipitate an attack. Pathology.—No demonstrable causal lesions are detected. The disease apparently depends upon an instability of the motor centres, so that from trivial exciting causes violent discharges occur from time to time. Symptoms. Grand Mai.—The seizure is often preceded by a peculiar sensation termed au aura, beginning in a finger or toe and rising until it involves the head, when the patient gives a shrill scream and falls to the floor unconscious. At first the face is pale, the pupils contracted, and the body thrown into a tonic spasm in which the head is retracted and rotated, the limbs forcibly extended, and the thumbs turned into the palms and firmly clenched by the flexed fingers. In a few seconds the tonic spasm relaxes, the movements become clonic or intermittent, the pupils dilated, the face cyanosed, and from the violent contraction of the masseters frothy saliva, often blood-streaked, pours from the mouth. The clonic spasms continue for a minute or two, and are generally followed by a period of coma lasting from a few minutes to several hours. Sometimes the patient returns at once to consciousness, and complains simply of weakness, muscular soreness, and mental confusion. More rarely the convulsion is followed by an out- 25 386 DISEASES OF THE NERVOUS SYSTEM. break of mania, or of epileptic automatism, a condition in which the patient performs some incongruous act. Petit Mai.—In this type the seizure consists of momentary unconsciousness, with pallor, and perhaps twitching of the muscle. The patient suddenly stops in the midst of his work or conversation, remains quiet for a few seconds, and then con- tinues where he left off, perhaps unconscious of the interrup- tion. Petit mal may be a forerunner of grand mal or may alter- nate with it. Between these two extremes, the seizures manifest all grades of severity. The frequency of the paroxysms varies consider- ably ; they may occur as seldom as once a year, or as often as ten or twelve times a day. A marked periodicity in their re- currence is often observed. The term " status epilepticus" is applied to a series of con- vulsions which follow each other in rapid succession, and which are associated with high fever. The epileptic may manifest no other symptoms beyond the convulsions, but when the latter are very frequent the health fails and the mental power deteriorates. Diagnosis.-—The convulsions of idiopathic epilepsy must be distinguished from those due to organic brain disease (organic epilepsy). The latter affection rarely develops before twenty- five ; the aura may be connected with the special senses, which is uncommon in idiopathic epilepsy; the convulsion is often confined to one member or to one side of the body, and may not be associated with unconsciousness (Jacksonian epilepsy); the convulsion may begin in one member and then become generalized; and finally, in a large proportion of the cases of organic epilepsy, there will be a history or concomitant symp- toms of syphilis, or the evidence of cerebral injury. Uraemia.—Uremic convulsions may be recognized by the history and the results of the urinary analysis. Prognosis.—Generally unfavorable. Arrest of the dis- ease is rare, but amelioration is often secured by treatment. Treatment. Preventive,—Careful search should be made for the cause which excites the paroxysms; this will often be found in some disturbance of the gastro-intestinal tract. The diet should be light, and as a rule, largely vegetable. Con- APHASIA. 387 stipatioirmust be relieved by diet, exercise, or the use of mild laxatives. Undue mental and physical excitement should be avoided. Systematic exercise and frequent bathing followed by friction of the skin lessen the sensitiveness of the nervous system. The most reliable drugs are the bromides; one or two drachms of a combination of the bromides of sodium, potassium, aud ammonium may be given daily. The tendency to acne may be considerably lessened by the addition of a drop or two of Fowler's solution with each dose. A small amount of antipyrin often lessens the amount of the bromide required to check the convulsions. J$. Amnion, bromid., 3yj; Antipyrin, 3j ; Liq. potass, arsenitis, f^j ; Aq. menthse pip., q. s. ad f^vj.—M. (WOOD.) Sig.—Tablespoonful in water night and morning. AVhen the bromides fail, one of the following remedies may be employed: oxide of zinc (gr. vj-xv a day), picrotoxin (gr. Y^y thrice daily), sulphonal, borax, or belladonna. AVhen an aura gives warning of a seizure, the inhalation of nitrite of amyl may abort it. Surgical interference is indicated in Jacksonian epilepsy, and in those cases in which the convulsion begins in one mem- ber and subsequently becomes generalized. The Attack,—Injury of the tongue may be prevented by placing a piece of cork between the teeth ; as the seizure is of short duration no special medication is required. In the status epilepticus, chloroform or nitrite of amyl may be administered by inhalation, and hyoscine (gr. Tfo) or morphia given hypo- dermically. APHASIA. (Aphemia.) Definition.—An inability to express thoughts in words or to interpret perceptions. Motor or Ataxic Aphasia.—In this form the patient has lost the mechanism whereby thoughts are converted into words, although he may be able to repeat the words after another, to 388 DISEASES OF THE NERVOUS SYSTEM. write them, or to read them. The lesion producing this form of aphasia is located in the left third frontal convolution. Agraphia is an inability to express thought in written lan- guage. It is usually associated with motor aphasia. Alexia is an inability to express written language in words. It is also commonly associated with motor aphasia. Sensory Aphasia.—This is an inability to interpret percep- tions. There are the following varieties :— Word-blindness.—This is au inability to interpret written language. The lesion is usually in the supramarginal and angular gyri of the left side. Word-deafness.—An inability to interpret spoken language. The lesion is in the posterior part of the first and second tem- poral convolutions. Mind-blindness (Apraxia, Visual Amnesia).—An inability to recognize the use or import of an object. Seeing an object awakens no intelligent idea of its use. Mind-deafness (Auditory Amnesia).—An inability to inter- pret sounds. The patient hears the words, can recognize and repeat them, but cannot interpret them. Paraphasia.-—An inability to use the right word in continued speech. He can interpret and use words, but is constantly misplacing them. Amnesic Aphasia.—This term is employed to designate an entire loss of word-memory. It includes both motor and sensory aphasia. Pathology.—The lesions which produce aphasia are manifold; the most important are : Tumor, gumma, abscess, depressed fracture, embolism, thrombus, or softening in the localities which correspond to the various forms of aphasia. In right-handed subjects the lesion is on the left side of the brain ; in the left-handed it may, however, be on the right side. Aphasia is not always due to organic disease; it may be noted in congestion of the brain, in sudden fright, in the convales- cence of fevers, in migraine, after epileptic seizures, and in hysteria. Diagnosis.—Aphasia must be distinguished from aphonia. The latter condition is an inability to utter sounds, a power not lost in aphasia; moreover, aphonia is generally dependent VERTIGO. 389 upon some abnormality of the larynx or of the nerves leading thereto. Prognosis. —This depends entirely on the cause. After apoplexy the prognosis should be guarded. In cerebral soft- ening it is absolutely unfavorable. AVhen aphasia develops in the young the outlook is much more hopeful. Treatment.—The causal condition will require attention. The patient may be instructed to speak and to interpret after the manner employed in teaching the young. VERTIGO. (Dizziness, Giddiness, Swimming in the Head.) Definition.—A sense of unstable equilibrium in which the patient himself or surrounding objects appear to be in a state of rapid oscillation or rotation. It is a symptom of many conditions. Etiology.—Vertigo may result from :— 1. Cerebral anemia or congestion. The dizziness preceding a fainting fit is an illustration of the former, and that follow- ing exposure to the rays of the sun is an illustration of the latter. Vertigo is often a pronounced symptom of chronic cerebral congestion and auemia. The vertigo of chronic heart disease and of neurasthenia is included under this head. 2. Reflex irritation. The most common example of this form is the vertigo dependent upon gastric disturbances. It is also noted in eye-strain, uterine disease, constipation, and disease of the internal ear. The last is termed labyrinthine vertigo, or Meniere's disease, and has been described elsewhere. 3. Organic disease of the brain and cord. Cerebral tumor, meningitis, and softening are frequently associated with vertigo. It is often quite marked in cerebellar disease. It may be a pronounced symptom in disseminated sclerosis and locomotor ataxia. 4. Toxic substances in the blood. The vertigo observed in lithemia, uremia, and diabetes is included under this head. AVhen taken in large doses, certain drugs, as alcohol, bella- donna, cannabis indica, lobelia, and conium, may produce the 390 DISEASES OF THE NERVOUS SYSTEM. symptoms. It is often a marked symptom of chronic lead- poisoning. 5. Epilepsy. Vertigo may precede, follow, or take the place of an epileptic seizure. 6. Hysteria. Occasionally marked vertiginous attacks are connected with hysteria. 7. Unknown causes. The term essential vertigo has been applied to those cases in which, after the most exhaustive study, no adequate cause can be ascertained. There is some- times an hereditary tendency to this form of vertigo. Diagnosis.—Vertigo must be distinguished from pepit mal, or minor epilepsy. The history, the presence of a definite cause, and the absence of unconsciousness and of convulsive move- ments will serve to separate vertigo from epilepsy. The determination of the cause of the vertigo must be based upon the history, the age at which it develops, and a critical examination of the various organs. Prognosis.—This will depend entirely on the cause ; when the latter can be removed, the prognosis is favorable. Treatment.—This must be directed to the causal condition. MENIERE'S DISEASE. (Labyrinthine Vertigo, Aural Vertigo.) Definition. — Paroxysmal vertigo, probably depending upon disease of the internal ear. Etiology and Pathology. — The exact cause of Meniere's disease is still undetermined. In some cases, how- ever, inflammatory changes have been observed in the semi- circular canals. It is probable that mild forms of the disease can be indirectly induced by lesions of the middle ear. Symptoms. — Frequently prodromes precede the attack, such as deafness or earache. These, however, may be absent, and the attacks ushered in with extreme vertigo and tinnitus aurium. The latter is often compared to the escape of steam, the buzz of an insect, or the discharge of a cannon. The patient feels as if he or surrounding objects were being whirled vio- lently around, and in severe cases the face is pale and anxious; hysteria. 391 the surface is clammy ; there are nausea and vomiting; and the patient falls unconscious. As a rule, there is deafness in one ear at least, but ex- ceptionally, hearing may be quite normal. At first the paroxysms may occur at long intervals, but as the disease advances they become more frequent and the tinnitus and deafness become more marked. Diagnosis.—The paroxysmal vertigo, deafness, and tinnitus aurium are the diagnostic features. Prognosis.—The prognosis should always be guarded. Some cases recover entirely, but in the majority the vertigi- nous attacks continue until the deafness in the affected ear becomes complete. Treatment.—The middle ear should be. carefully ex- amined, and any existing disease treated. Severe counter- irritation by blisters, or the actual cautery applied behind the ear, may be of some service. Bromide of potassium or large doses of hydrobromic acid may give temporary relief. Charcot recommends quinine in sufficient doses to cause cinchonism. HYSTERIA. Definition. — Hysteria is a functional disease of the nervous system, manifested by symptoms of the most varied character, which apparently result from a loss of control over the production of nerve-power. Etiology.—Females are especially predisposed, although it occasionally develops in males. It is most common in early adult life and at the menopause. The nervous temperament and such ancestral diseases as epilepsy, insanity, etc., favor its development. Prolonged emotional excitement, such as worriment, anxiety, grief, and all causes which lower the vitality serve to excite it in susceptible individuals. Pathology.—No causal lesions can be detected after death. Symptoms.__The various manifestations may be described under three heads: (1) Motor, (2) sensory, and (3) psychical. Motor Phenomena.—Paralysis not infrequently results from 392 DISEASES OF THE NERVOUS SYSTEM. hysteria; it may take the form of a hemiplegia, paraplegia, or monoplegia, although the first is by far the most common. The paralysis is generally paroxysmal, and is frequently asso- ciated with contractures and anesthesia. The affected muscles do not waste. Local paralysis is also common; thus there may be aphonia from paralysis of the vocal cords; dysphagia, from paralysis of the oesophagus; and incontinence of urine, from paralysis of the bladder. Convulsive seizures are common manifestations of hysteria, and may closely simulate the paroxysms of true epilepsy; but there is no aura; the patient usually falls in a comfortable place; consciousness is only apparently lost, for after the seiz- ure she remembers all that has transpired; the tongue is rarely bitten ; the eyes are partially closed; the face is expressive of some emotion ; screaming or sobbing is of frequent occurrence; the movements are apt to be tonic, so that the patient assumes the position of opisthotonos, or if clonic, they are apt to be violent and purposive; the seizures are of long duration, and may be continued for several hours or days, and firm pressure over the ovaries may exaggerate or re-excite them. The spasms may be local; thus there may be retention of urine, from spasm of the bladder; asthma, from spasm of the bronchi; hiccough, from spasm of the diaphragm; persistent vomiting, from spasm of the stomach ; dysphagia, from spasm of the oesophagus; and a " phantom tumor," from spasm of abdominal muscles associated with flatulent distention of the intestines. Among other motor phenomena may be mentioned obsti- nate tremors, choreiform movements, and contractures of cer- tain groups of muscles. Sensory Phenomena.—There may be a complete loss of sen- sation in certain parts, as one side of the body. Anesthesia without other nervous phenomena is usually hysterical. In some cases tactile sensation is preserved and there is a loss only of thermic or painful sensations. The anesthetic part is often unusually pale, and when pricked with a needle fails to bleed (ischemia). The special senses maybe involved ; thus there may be con- HYSTERIA. 393 traction of the field of vision, complete blindness, loss of smell, loss of taste, or loss of hearing. These special-sense palsies are usually transient, and often alternate with one another. Instead of anesthesia, there may be hyperesthesia or pain. Severe pain in the stomach may simulate gastralgia. An ex- quisitely painful and tender condition of the abdomen may be mistaken for peritonitis. A localized pain in the head, described as resembling the effect of a nail being driven into it, is termed hysterical elavus. The joints sometimes become swollen and very tender, resembling arthritis (neuromimesis). Intense pain over the heart may simulate angina pectoris. The spine is often the seat of hyperesthesia, especially in spots, and this spinal irritation is often associated with pain in parts corresponding to the distribution of nerves which have their origin in the hyperesthetic area. A very common abnormal sensation is the globus hystericus, i. e., a feeling as of a ball rising in the throat and impeding respiration. Psychical Phenomena.— Frequently the only conspicuous mental phenomenon is the great lack of will-power; but gen- erally the patients are more or less excitable, highly mercurial, and easily moved to laughter or tears. They frequently mani- fest a great fondness for sympathy, and this, in connection with their weak will-power and lowered moral tone, often leads them to feign symptoms which they really do not have. Among the more serious mental manifestations may be mentioned insanity, ecstasy, catalepsy, and trance. Diagnosis.—The recognition of hysteria is often attended with great difficulty, especially as it is frequently associated with svmptoms which really have an organic basis. In making a diagnosis, the history, sex, and temperament must be carefully considered. The manifestations usually develop abruptly; are generally paroxysmal; appear without obvious cause ; often subside spontaneously uuder some emotional excitement; rarely lead to any impairment of the health ; and are usually associated with a history of other hysterical phenomena. Prognosis.—As regards life the prognosis is good. In rare instances death has followed exhaustion induced by re- peated convulsions or prolonged fasting. AVhile hysteria 394 DISEASES OF THE NERVOUS SYSTEM. usually ends in recovery, the duration of the illness is a mat- ter of great uncertainty. A speedy recovery is to be expected in those cases where the hysterical phenomena are connected with some obvious cause which can be removed. Treatment.—Careful search should be made for some exciting cause, which, if found, should be removed as far as possible. The physical condition is generally reduced, and careful study must be given to the diet, exercise, amusement, clothing, etc., with the view of improving it. Tonics like iron, arsenic, strychnia, hypophosphites, cod-liver oil, and malt are often indicated, and they may be advantageously combined with such nerve sedatives as valerian, asafoetida, sura- bul, and the like; in the milder manifestations, the following pill may prove useful:— R Acid, arsenosi, gr. £; Ferri sulph. ex., Ext. sumbul, aa gr. xx ; Asafcetidse, gr. xl.—M. (Goodell.) Ft. in pil. No. xx. Sig.—One after each meal. Or— I£. Quinin. valerianate, Zinci valerianat., Ferri valerianat., aa gr. xxiv.—M. Ft. in pil. No. xxiv. Sig.—One, thrice daily. The more thoroughly the physician is able to inspire con- fidence and to control his patient, the more likely is he to effect a cure. Firmness tempered with kindliness and en- couragement is essential to success. While hypnotism appears to have been somewhat useful in France, in this country, although employed but to a limited extent, it has not given encouraging results, and moreover, in the event of failure, seems capable of aggravating the hysteri- cal condition. In long-continued convulsive seizures, cold water may be dashed on the face and chest, or hyoscine administered hypodermically. In obstinate cases an anesthetic should be employed. In the various form of paralysis electricity is NEURASTHENIA. 395 often useful. In some cases static electricity, no doubt from the profound mental effect which it has induced, has given excellent results. In aggravated cases the " rest-cure" introduced by S. AVeir Mitchell is often applicable. It consists in isolation from sympathizing friends and relatives; abundant feeding, espe- cially with milk; and complete rest of body and mind with passive exercise obtained by massage and electricity. NEURASTHENIA. (Nervous Prostration.) Definition.—A term applied to a group of symptoms apparently resulting from exhaustion of the nerve-centres. Etiology.—A neuropathic tendency, prolonged mental work, or emotional excitement, excesses, and irregular living are general predisposing factors. Symptoms. Cerebral Symptoms.—Depression of spirits, indisposition, inability to concentrate the mind on one subject for any length of time, insomnia, vertigo, headache, irritability of temper, and hysterical manifestations. Spinal Symptoms.—Sometimes these predominate, when the condition is termed spinal irritation, and its chief manifesta- tions are: Pain in the back, spots of tenderness along the spine, weakness of the extremities, great prostration after moderate exertion, and various subjective phenomena, such as numbness, tingling, formication, and neuralgic pains. Gastro-intestinal Symptoms.—Anorexia, coated tongue, and constipation. Circulatory Symptoms.—Palpitation, cold extremities, and sometimes violent pulsation of the aorta. Sexual Symptoms.—In females, amenorrhea or dysmenor- rhoea; in males, impotence or spermatorrhea. The disease is inseparably associated with cerebro-spinal anemia, hysteria, and hypochondriasis. Diagnosis. — The diagnosis is rarely difficult. Before relegating a case to this class, care must be taken to exclude organic disease, and such general disorders as lithaemia. 396 DISEASES OF THE NERVOUS SYSTEM. Prognosis.—AArhen the cause can be removed and the patient controlled, the prognosis is favorable. Treatment.—The treatment is largely hygienic and die- tetic, and will vary considerably in different cases. AVhere there has been inactivity, regulated physical exercise will be of great value; on the other hand, the weak and anemic will require rest. In the latter case, the plan of treatment intro- duced by S. Weir Mitchell, and known as the "rest-cure," often gives brilliant results. In all cases careful attention must be given to the diet, bathing, and clothing, and the patient assured that he is suffering from no incurable disease. Frequent bathing with salt water, followed by friction of the skin, will often add to the general vigor. Tobacco and alco- hol must be interdicted, and tea and coffee used very sparingly. Tonics like iron, arsenic, quinine, strychnia, and phosphorus are often indicated. CHOREA. (Chorea Minor, St. Vitus's Dance.) Definition.—A nervous affection occurring especially in children, and characterized by irregular movements which in- crease under excitement and cease during sleep. Etiology.—Childhood (between five and fifteen), female sex, nervous temperament, and the rheumatic diathesis are general predisposing factors. It sometimes develops suddenly after mental or emotional excitement, such as anxiety, fear, or grief. It may be excited by reflex irritation, as an adherent prepuce, intestinal parasites, etc. It not infrequently develops in the course of pregnancy. Pathology.—It is customary to look upon chorea as a neurosis, since no constant lesions have been discovered to account for its clinical manifestations. In some cases endo- carditis, and emboli in the minute cerebral vessels have been discovered, but their relation to chorea has not yet been de- termined. Symptoms.—The first manifestations are usually restlessness and awkwardness in movement. The child cannot remain stillj but is constantly raising its shoulders, jerking its head, CHOREA. 397 twisting its fingers, or shuffling its feet. Frequently these symptoms develop so insidiously that the disease is not recog- nized, and the child is punished for being fidgety. AVhen the disease is fully established the disorderly move- ments become more marked, and may be confined to one member or may involve the entire body. AVhen the facial muscles are affected, the most grotesque expressions are pro- duced ; involvement of the arms may interfere with eating and dressing; when the legs suffer the gait becomes jerking and stumbling ; involvement of the larynx causes stammering ; and spasm of the muscles of deglutition induces difficult swallowing and choking-spells. AVhen the attention is directed to the movements they invariably grow worse, but they diminish during repose and cease entirely during sleep. Sometimes, in addition to the involuntary movements, there is a distinct loss of power in the affected members. The general health is usually more or less impaired. The child is anemic; the temper is irritable; and the mental power deficient. Aus- cultation of the heart often detects a murmur which may be either an expression of anemia or of complicating endocarditis. In some cases (chorea insaniens) the movements are so violent that the patient is unable to walk, eat, or even to lie down. Fever develops, and ultimately the mind becomes de- lirious. Death frequently results from exhaustion. This form is usually observed in adults, and especially in primipare. Diagnosis.—The recognition of chorea is rarely attended with difficulty. Disseminated spinal sclerosis may be dis- tinguished by the presence of nystagmus, a scanning speech, increased reflexes, and a rhythmical tremor which is only ex- cited by movement. Prognosis.—In simple chorea recovery usually follows in the course of two or three months. Death from heart com- plications is a rare termination. Relapses are not infrequent. Among the possible sequele may be mentioned imbecility and chronic chorea. Chorea insaniens frequently terminates fatally through ex- haustion. Treatment.—Rest of body and mind is an essential ele- ment of the treatment. The child should be taken from 398 diseases of the nervous system. school and placed under the most favorable hygienic condi- tions. Careful search should be made for reflex irritation, such as adherent prepuce, intestinal parasites, eye-strain, etc. All excitement must be avoided. Amusement in the open air when the weather is fine is to be recommended. As the child is generally anemic, iron is indicated in the majority of cases. Among the special remedies arsenic holds the first place. Fow- ler's solution may be given in doses of two drops thrice daily, gradually increased to eight or ten drops thrice daily. Among other remedies may be mentioned the fluid ext. of cimicifuga (nix increased to 3j thrice daily), hyoscyamine (gr. xioTo o")' and quinine (gr. iij-v every two or three hours). In Chorea insaniens forced feeding should be resorted to. Morphia and other sedatives may be employed hypodermi- cally. Chloroform may be required to control temporarily the movements. Severe cases of chorea complicating preg- nancy will call for the induction of premature labor. PARALYSIS AGITANS. (Parkinson's Disease, Shaking Palsy.) Definition.—A chronic nervous disease, characterized by a fine, slowly-spreading tremor, muscular weakness and rigidity, and a peculiar gait, termed festination. Etiology.—Advanced life, a neuropathic tendency, mental strain, and exposure to cold and wet are predisposing factors. It sometimes develops suddenly after intense mental or emo- tional excitement. Pathology.—The pathology is unknown. No definite lesions have been found to account for the clinical manifesta- tions. Symptoms.—In some cases the onset is abrupt, but more commonly the disease develops insidiously. The first symptom is usually a fine tremor beginning in the hand or foot, which may slowly spread until it involves all the members; the head is rarely affected. At first the tremor may be parox- ysmal, but as the disease advances it becomes almost continuous. Excitement increases it, but it is noteworthy that physical effort temporarily diminishes or checks it The face becomes PARALYSIS AGITANS. 399 expressionless, and the speech slow and measured. Later, muscular rigidity develops; the head is bowed, the body bent forward, the arms flexed, the thumbs turned into the palms and grasped by the fingers, and the knees slightly bent. At this time the gait is characteristic: the steps grow faster and faster, the body inclines more and more forward until the patient falls, seeks support in some neighboring object, or straightens himself by a supreme effort of the will. The term ^ festincdion has been applied to this peculiar gait. Occasionally a tendency to fall backwards—retropulsion-—replaces festina- tion. The rigidity and muscular weakness render all move- ments slow and labored. Intelligence is usually good. There is no anesthesia, but there are various manifestations of paresthesia, such as numb- ness and tingling; a sensation of heat is especially noted. In some cases free perspiration has been observed. Diagnosis.—The tremor, rigidity, weakness, flexion of the body and members, lack of facial expression, and festination are the diagnostic features. In some cases the tremor is absent. Paralysis agitans must be distinguished from disseminated sclerosis. In the latter the tremor is coarse, is frequently ab- sent when the patient is quiet, and is made worse by efforts to control it; cerebral symptoms are generally present; nystag- mus is often noted; and the attitude and gait are entirely different from those of paralysis agitans. Prognosis.—Recovery rarely, if ever, occurs. In some cases, after reaching a certain point, the disease remains sta- tionary. The progress is slow and the duration indefinite. Treatment.—Measures intended to improve the tone of the system are indicated ; these are : A regulated diet, rest of body and mind, frequent bathing followed by friction of the skin, and the use of such tonics as iron, arsenic, and phos- phorus. The rigidity and tremors are sometimes improved by massage and electricity. Among the remedies recommended for the tremors are bromide of potassium, hyoscyamine (gr. yi-^), and hyoscine (gr. jfa), but the improvement follow- ing their use is only slight and temporary. 400 DISEASES OF THE NERVOUS SYSTEM. ARTISANS' CRAMP. Definition.—A spasmodic affection of the muscles in- duced by prolonged work requiring delicate coordination, and occurring only in the performance of that particular work. Etiology.—It is more common in men than in women, and the nervous temperament predisposes to its development. . The occupations in which it is most apt to occur are writing, piano-playing, sewing, and telegraphing. Pathology.—The disease is evidently not peripheral, for when the other hand is substituted the condition soon develops in that member. It is probably dependent upon unnatural irritability of the nerve-centres. Writers' Cramp. (Graphospasm, Scriveners' Palsy.) Symptoms.—The condition usually begins with a sense of fatigue, weight, or actual pain in the affected muscles. Soon the fingers are seized with a tonic or clonic spasm whenever the pen is grasped (spastic form). In some cases the hand when put into use becomes the seat of a decided tremor (tremulous form); in a third group of cases the chief phe- nomena are excessive weakness and fatigue, which disappear as soon as the pen is laid aside (paralytic form). Prognosis.—Guardedly favorable. The disease is obsti- nate, but cure generally follows protracted rest. Treatment.—Absolute rest is the essential element of treatment. The general condition should be improved by iron, arsenic, strychnia, and cod-liver oil. Massage, electricity, and passive movements give good results. TETANY. (Tetanilla, Intermittent Tetanus.) Definition.—A nervous affection, characterized by tonic spasms which are usually paroxysmal and involve the ex- tremities. Etiology.—It is most frequently observed in the young. In women it is frequently associated with pregnancy or lacta- thomsen's disease. 401 tion. It is sometimes excited by exposure, emotional excite- ment, or one of the infectious fevers. An epidemic form has been described, but some of the outbreaks seem to have been hysterical. A very grave form has been induced by thyroid- ectomy and by lavage in gastric dilatation. Symptoms.—The patient is seized with bilateral tonic spasms in the arms and legs. The jaws are rarely involved. The contractions are usually paroxysmal and are attended with pain. As was pointed out by Trousseau, they can be induced by pressure over the arteries and nerves of the affected limb. The electro-contractility of the muscles is greatly exaggerated. There may be slight oedema. Sensation is not disturbed ; the mind is clear ; and fever is slight or entirely absent. Diagnosis.—Hysteiia may simulate tetany, but the history and the unilateral character of the contractions will distinguish it from tetany. Tetanus.—In this disease the spasms are continuous and early involve the jaws and trunk. Prognosis.—Usually favorable. Attacks following thy- roidectomy and lavage sometimes prove fatal. Treatment.—Good hygiene ; tonics; electricity ; sedatives like bromide of potassium, belladonna, and chloral. AVarm or cold baths, followed by friction. THOMSEN'S DISEASE. (Congenital Myotonia.) Definition.—A disease confined to certain families, and characterized by tonic spasms of the muscles, induced by voluntary movements. Etiology.—The disease is usually congenital, and trans- mitted from one generation to another. Several members of the same family are commonly affected. Pathology.—Unknown. Symptoms.—The disease appears in early childhood, and is manifested by a tonic spasm of the muscles every time they are put in use; this is especially marked after periods of in- activity. In a few moments the rigidity wears away and the movements become free. From repeated contractions the 26 402 DISEASES OF THE NERVOUS SYSTEM. muscles become firm and extremely well developed. Under electrical stimulation the muscles contract and relax slowly. Prognosis.—Incurable. Treatment. — The condition improves under physical exercise. EXOPHTHALMIC GOITRE. (Graves's Disease, Basedow's Disease.) Definition.—A nervous affection, characterized by pro- trusion of the eyeballs, enlargement of the thyroid gland, and palpitation. Etiology.—Early adult life, female sex, and nervous tem- perament are the predisposing causes. It sometimes develops suddenly under emotional excitement, such as fright, grief, and anxiety. Pathology.—In most cases no lesions are found after death to account for the symptoms. It has generally been regarded as a disease of the sympathetic system, and in some instances changes have been found in the cervical ganglia; but the mental phenomena and the accelerated pulse cannot be explained on the theory of sympathetic paralysis. The prominence of the eyeballs is for the most part due to dilata- tion of the vessels in the back of the orbits; and the enlarge- ment of the thyroid gland is due to a similar condition. Symptoms. Cardiac Phenomena. — Acceleration of the pulse (100-150) and palpitation, both greatly exaggerated by excitement; hypertrophy of the heart from its rapid action; occasionally a soft systolic murmur at the apex. Ocular Phenomena.—Bilateral protrusion of the eyeballs; Graefe's sign, which consists in a failure of the upper lid to follow the eyeball when the latter is directed downwards; widening of the palpebral angle (Stellwag's sign). Vision is usually unimpaired. Thyroid Phenomena.—Enlargement of the thyroid is often the last symptom to appear; one or both lobes of the gland may be affected. Inspection reveals enlargement with pulsa- tion ; palpation detects a soft swelling and a purring thrill; auscultation may yield a bruit. Raynaud's disease. 403 Nervous Phenomena.—The following are sometimes ob- served : A tremor of the hands or of the entire body; hypo- chondriasis ; acute mania; or vitiligo and chloasma. General Phenomena. — Anemia, failure of health and strength, and slight febrile paroxysms. Diagnosis.—It should be borne in mind that one of the three important symptoms may be absent throughout the disease. In some cases palpitation and throbbing of the cervical vessels may be the only phenomena. Goitre may be distinguished from exophthalmic goitre by the absence of cardiac, ocular, and nervous symptoms. Prognosis.— The disease generally runs a protracted course. Some cases recover entirely ; many improve and subsequently relapse; a few die, after a short illness, from heart failure or acute mania. Treatment.—The general nutrition must be improved by rest, a liberal diet, and the use of such tonics as iron, quinine, and arsenic. The application of mild galvanic currents to the neck is often very useful. When the palpitation is marked, prompt relief often follows absolute rest and the application of an ice-bag to the precordia. The most reliable internal remedies are strophanthus, digitalis, belladonna, and ergot. Bromide of potassium is sometimes useful in controlling the nervous symptoms. Operative Interference.—Ligation of the arteries and ex- tirpation of the gland cannot be recommended. RAYNAUD'S DISEASE. (Symmetrical Gangrene.) Definition.—A vaso-motor neurosis, characterized by local anemia, congestion, or gangrene. Etiology.—The cause is unknown. The disease probably consists in a local spasm or paresis of the vessels. Symptoms.—In one form the part, usually the finger, be- comes extremely pale, cold, and anesthetic (local syncope). After a variable time these phenomena disappear and are fol- lowed by redness, heat, and tingling; such attacks may be excited by cold, and come and go without damaging the part. 404 DISEASES OF THE NERVOUS SYSTEM. In another form the affected part becomes swollen, dark red, and painful (local asphyxia), and if the attack persists bulle may appear and gangrene develop. The gangrenous areas are often symmetrical, involving a finger on each hand, a toe on each foot, or both ears.. Hemoglobinuria may occur in, or replace, an attack. Prognosis.—The attacks persist, but life is not endangered. In rare instances extensive gangrene develops and is followed by death. Treatment.—Patients liable to attacks should be well protected against cold. Tonics are often indicated. Frequent bathing followed by friction is useful. Raynaud advises the use of a continued current, one pole over the spine and the other over the affected area. ACUTE ANGIO-NEUROTIC (EDEMA. Definition.—A neurosis characterized by transient circum- scribed edema developing without obvious cause. Etiology.—Beyond a distinct hereditary tendency nothing is known of its cause. According to Quincke, there is a tem- porary vaso-motor dilatation of the vessels followed by the transudation of serum. Symptoms.—O3dematous swelling suddenly appears in some part of the body, particularly in the face and hands. Coinci- dent with the edema there may be marked gastro-intestinal symptoms such as vomiting, gastralgia, and colic. The disease is allied to urticaria and the latter may precede the outbreak. The attacks may occur at intervals of a few weeks. Prognosis.—The peculiar tendency persists; unless the larynx is involved, it is unattended with danger. Treatment.—General tonics, like iron, quinine, and strych- nia, are sometimes useful. MYXCEDEMA. Definition.—A constitutional affection, characterized by mucoid degeneration of the subcutaneous tissues, atrophy of the thyroid gland, and mental impairment. FACIAL hemi-atrophy—ACROMEGALIA. 405 Etiology.—The causes are unknown. It is of more frequent occurrence in women than in men. Symptoms.—It is manifested by swelling, particularly marked in the face and upper extremities. Unlike simple oedema, the parts do not pit on pressure. The skin is harsh and dry. The thyroid gland is atrophied. Among other symptoms are failure of memory, slowness of thought and speech, unsteady gait, and, towards the close, dementia. Congenital myxedema is observed in cretinism, and a similar condition sometimes follows removal of the thyroid. Prognosis and Treatment.—The disease runs a long course, and has been considered incurable, but it is now claimed that the fresh juice of thyroid glands is capable of effecting a cure. FACIAL HEMI-ATROPHY. (Unilateral Progressive Atrophy of the Face.) Definition.—A rare affection, characterized by progres- sive wasting of tissues—bones and soft parts—on one side of the face. Etiology.—The disease usually develops in childhood. It has been excited by injury of the face. Pathology. —In the few cases examined chronic trigeminal neuritis or lesions of the Gasserian ganglion have been dis- covered. Symptoms.—The first phenomenon is often discoloration of the skin; this is soon followed by a slow wasting of all the tissues on the affected side of the face. The hair falls; the eye is sunken ; and the teeth drop out. Prognosis.—The disease is progressive and incurable. ACROMEGALIA. (Marie's Disease.) Definition.—A nutritional disease, characterized by en- largement of the bones and overlying tissues, chiefly of the hands, feet, and face. Etiology.—Unknown. It usually develops in early adult life. 406 DISEASES OF THE NERVOUS SYSTEM. Pathology.—Examination of the bones reveals a true hypertrophy, particularly* of the cancellous structures. In some cases the pituitary body has been very much hypertro- phied and the thymus gland persistent. Symptoms.—The hands and feet are considerably enlarged, especially in breadth ; the fingers and toes are stumpy and the nails are flat and small. Hypertrophy of the inferior maxil- lary bone leads to elongation of the face and protrusion of the lower jaw. The lips are large and everted. Among occa- sional symptoms may be mentioned spinal curvature, polyuria, glycosuria, persistent headache, deafness, blindness from atrophy of the optic nerve, loss of sexual power, and in women, menstrual disorders. Diagnosis.—Acromegalia might be mistaken for myxce- dema, but in the latter the soft parts only are involved; the skin is firm and adherent, instead of soft and mobile as in acromegalia ; and the face is round. In Paget's osteitis deformans the long bones are especially involved, and are not only enlarged, but considerably deformed; and the face has a peculiar triangular shape. Prognosis.—The affection is incurable, but the duration is indefinite. Treatment.—So far, remedies have been futile. SUNSTROKE. (Heat-stroke, Thermic Fever, Coup de Soleil, Insolation, Heat- exhaustion.) Definition.—An affection resulting from exposure to ex- cessive heat. Varieties.—Two varieties are observed: Thermic fever and heat-exhaustion. Thermic Fever. Pathology.—After death from thermic fever rigor mortis develops early and is marked. The various organs, especially the brain, are deeply congested. The left ventricle is firmly contracted, and the right is dilated and filled with blood. The SUNSTROKE. 407 blood is dark and uncoagulated. Microscopic examination of the tissues reveals parenchymatous degeneration, or cloudy swelling. Symptoms.—Prodromes are frequently present and consist of exhaustion, vertigo, nausea, and headache. These symp- toms are followed by coma, and in this state the face is flushed ; the eyes are injected; the skin is dry and burning; the tem- perature ranges from 106° to 112° ; the pupils are contracted ; the respirations are rapid and noisy; and the pulse is full and rapid. Unless the temperature soon falls the respirations become shallow, the pulse weakens, and death results in a few hours. There is a very malignant form in which the patient is suddenly stricken comatose and dies in a few hours from cardiac failure. Sequelae. — Meningitis ; epilepsy ; insanity ; failure of memory ; and extreme sensitiveness to high temperature. Diagnosis.—The conditions under which the coma has de- veloped, together with the extremely high temperature of the body, will serve to distinguish sunstroke from apoplexy, alco- holism, and uremia. Prognosis.—Very guarded. Probably forty per cent. perish. Treatment.—The patient should be promptly placed in a bath of ice water and should be rubbed with ice. Ice-water enemata are also useful. Antipyrin has been administered subcutaneously with good results. When the pulse is full and strong venesection may be a valuable adjunct to the anti- pyretic treatment. Heat-exhaustion. Pathology.—According to AVood, heat-exhaustion depends on a vaso-motor paresis, as a result of which there is a deter- mination of blood from the brain and surface of the body to the great bloodvessels of the abdomen. Symptoms.—The mind is dazed, but consciousness is not lost; the surface is pale and cold ; the skin is moist; the res- pirations are shallow and hurried ; and the pulse is rapid and feeble. 408 diseases of the nervous system. Prognosis.—Recovery soon follows under appropriate treat- ment. Treatment.—The patient should be covered with hot blankets, and hot bottles should be placed near the feet. Brandy, ammonia, and strong coffee are useful stimulants. Strychnia hypodermically is a very efficient remedy. ALCOHOLISM. (Dipsomania.) Acute Alcoholism.—After excessive indulgence in alcohol the following symptoms are observed : Flushing of the face, quickening of the pulse, and mental exhilaration, followed by incoherent speech, loss of coordination, vomiting, delirium, slow pulse, subnormal temperature, and, finally, stupor and coma. Occasionally the coma is replaced or interrupted by convulsive seizures. In the majority of cases, recovery follows in the course of a day or two; but sometimes the coma deepens and death results. Chronic Alcoholism.—This condition is characterized by a fine tremor, mental impairment, disturbed sleep, injection of the conjunctive, redness of the nose (acne rosacea), and the symptoms of chronic gastro-intestinal catarrh, namely, ano- rexia, coated tongue, fetid breath, nausea, vomiting, fulness and distress after eating, and constipation alternating with diarrhea. AVhen the habit is long continued, atheroma of the arteries, cirrhosis of the liver, and chronic interstitial nephritis are apt to develop. A very common complication of chronic alcoholism is delirium tremens (mania a potu). This condition usually follows a protracted debauch, or spree, or is excited by an in- jury or some intercurrent disease. Its chief manifestations are : Mental excitement, insomnia, incoherent speech, disordered intellect, tremors, and hallucinations, usually of sight and hear- ing. The last are of a terrifying character ; the patient hears threatening voices, or sees repulsive creatures—snakes, rats, loathsome insects, or demons—peering at him from behind every piece of furniture. In some cases the terror excited by these hallucinations is so great that, in a fit of maniacal ex- alcoholism. 409 citement, the patient rushes out into the street or jumps from the window. The pulse is rapid and feeble ; the appetite is entirely lost; the bowels are constipated; and the temperature usually elevated (101°-103°). In favorable cases, in the course of a few days or a week, the excitement abates, the appetite returns, sleep is restored, and convalescence established. In unfavorable cases, typhoid symptoms are apt to develop; these are: Irregular fever, weak pulse, dry, brown tongue, stupor, subsultus tendinum, carphologia, and finally, complete coma. Among other complications or sequele of dipsomania may be mentioned : Multiple neuritis, pneumonia, epilepsy, chronic meningitis, paretic dementia, and various psychoses. Diagnosis.—The coma of alcoholism must be distinguished from the coma of other diseases. The history, the absence of paralysis, the subnormal temperature, the fact that the patient can be aroused by screaming in the ear, or by firm pressure over some sensitive spot like the supraorbital notch, the odor on the breath, and the absence of other cause- will usually prevent an error in diagnosis. Delirium tremens is recognized by the history, restlessness, delirium, tremors, and terrifying hallucinations. The tremors of chronic alcoholism may be recognized by the history, the associated evidence of alcoholism, and by the fact that they are worse in the morning, and improve after the use of the stimulant. Prognosis.—In acute alcoholism the prognosis should be guardedly favorable. In delirium tremens recovery generally follows, unless there is great debility. In alcoholic pneumonia the outlook is grave ; recovery is exceptional. In alcoholic neuritis the symptoms usually subside under appropriate remedies and abstinence from the stimulant. In chronic alcoholism the prognosis is generally unfavorable. When the habit is fully established, it is rarely permanently broken; temporary improvement is only too often followed by a relapse. Treatment. Acute Alcoholism.—The stomach should be emptied by the stomach-pump, a stimulating emetic, or the hypodermic injection of apomorphia (gr. -fa-\). If the coma 410 diseases of the nervous system. persists and the pulse weakens, cardiac stimulants like ammonia, strychnia, and digitalis should be administered hypodermically. Douching and flagellation may also be employed to arouse the patient. Delirium Tremens.—Alcohol must be withheld unless the pulse is very weak. It is essential that the patient should receive sufficient nourishment, for usually little food has been taken during the debauch which led to the delirium. Highly- seasoned beef-tea and milk with lime-water are the best foods. Sleep must be secured by chloral (gr. xx), bromide of potassium (3ss-3j), hyoscine (gr. Tfo), morphia (gr. \, and repeated once or twice), or paraldehyde (5j). When the pulse is weak, strychnia (gr. -fa, repeated, watching the effect) is often of great value. In most cases physical restraint is essential; it is best secured by strapping the patient to the bed with sheets. Chronic Alcoholism.—It is necessary that alcohol shall be withdrawn ; the rapidity with which this can be accomplished will depend on the circumstances. In most cases the tempta- tion to drink is so strong that confinement in an inebriate asylum is essential to the success of the treatment. Various substitutes have been recommended for alcohol, among which may be mentioned bromide of potassium, chloral, cocaine, hyoscine, and cannabis indica. As a rule, they accomplish little beyond quieting the patient and occasionally securing sleep. The diet should be nutritious, and carefully adapted to the condition of the stomach, which is usually the seat of chronic catarrh. Tonics like iron, quinine, and strychnia are often indicated. Graduated physical exercise is sometimes of decided value. OPIUM-POISONING. Acute Poisoning. Symptoms. — A stage of excitement is followed by stupor, coma, contracted pupils, slow respirations, muscular relaxation, and a slow pulse. In the final stage the respirations become shallow and irregular, the pulse rapid and feeble, and the pupils dilated. Treatment.—The stomach should be emptied by a stimu- lating emetic or the stomach-pump. Strong coffee may be CHRONIC LEAD-POISONING. 411 given by the mouth. The patient should be aroused by flagellation, douching, forced walking, or the electric brush. The physiological antidotes—atropia and strychnia—should be given hypodermically in full doses, their effects being care- fully watched. Electricity may be employed to stimulate respiration. Morphine-habit. (Morphinism, Morphiomania.) Symp- toms.—Anemia, sallow complexion, an irresistible craving for the drug, dilated pupils, tremors, loss of appetite, restless- ness, insomnia, mental impairment, and a complete perversion of the moral nature. Treatment.—Confinement in an asylum is nearly always necessary. The opium should be withdrawn gradually. Such substitutes as cocaine, chloral, hyoscine, paraldehyde, and sulphonal may be employed temporarily. Respiratory stimu- lants like strychnia, and cardiac stimulants like digitalis, are often indicated. In the vast majority of cases "the habit is only suspended, not broken. CHRONIC LEAD-POISONING. (Plumbism, Saturnism.) Etiology.—Chronic lead-poisoning results from the slow absorption of lead, and is most commonly observed in work- men who handle the metal. Printers, type-founders, and workers in white-lead are especially liable to be affected. Oc- casional^ it results from the use of water which has been carried through lead pipes or which has been stored in cisterns lined with lead. Pathology. — The muscles are degenerated, and the pe- ripheral nerves frequently reveal evidences of chronic neuritis. In cases associated with marked muscular atrophy, polio- myelitis is discovered. Symptoms.—The following are the chief manifestations: Anemia; severe colicky pains centering around the umbilicus and associated with retraction and rigidity of the abdominal walls; constipation ; a blue line on the gums near the in- sertion of the teeth, due to the deposition of a sulphuret of lead; paralysis; tremors; intense headache; pains in the 412 diseases of the nervous system. joints (arthralgia); arterio-sclerosis; chronic interstitial ne- phritis ; and grave cerebral symptoms (encephalopathies). The Paralysis.—This in most instances involves the exten- sors of both forearms, and gives rise to the well-known wrist- drop. In advanced cases the muscles atrophy and yield the reactions of degeneration. Sensation is not affected. Encephalopathies.—These are among the more rare mani- festations of plumbism, and consist of convulsions, coma, delirium, intense headache, and blindness from atrophy of the optic nerves. Prognosis.—Guardedly favorable. Treatment.—Prophylaxis consists in absolute cleanliness; the use of respirators in lead factories; the avoidance of eating in an atmosphere laden with the dust of the metal; and in the occasional use of Epsom salts. The curative treatment consists in the administration of iodide of potassium (gr. v-x thrice daily) and the use of sulphur baths. Constipation should be relieved by Epsom salts. The colic may require the hypodermic injection of morphia and atropia, and the application of hot fomentations to the abdomen. The paralysis generally yields to massage, the constant current, and hypodermic injections of strychnia. CHRONIC MERCURIAL POISONING. Etiology—This is usually observed in those employed in quicksilver mines, or engaged in making mirrors, barometers, or other scientific instruments requiring the use of mercury. Symptoms.—Anemia, loss of flesh and strength, gastro-in- testinal disturbances, and marked tremors. The latter usually begin in the extremities, and are at first slight, but later the whole body is involved, and the tremors are violent. In ad- vanced cases they may continue during sleep. Grave cerebral symptoms occasionally develop, such as vertigo, headache, im- pairment of intellect, convulsions, paralysis, and coma. Diagnosis.—The history, the marked tremor of the head, and the absence of the peculiar gait (festination) will distin- guish it from paralysis agitans. CHRONIC ARSENICA I, POISONING. 413 The history and the absence of nystagmus will distinguish it from disseminated sclerosis. Treatment.—Removal from the influence of the metal. Tonics. Iodide of potassium. Electricity. Sedatives for the tremors. CHRONIC ARSENICAL POISONING. Etiology.—It is observed in workmen employed in arsenic works and glass factories. Inhaling the dust of fabrics, papers, artificial flowers etc., which have been colored with arsenic, may induce poisoning. Symptoms.—Anemia, loss of flesh and strength, conjunc- tivitis, gastro-intestinal catarrh, loss of hair, cutaneous erup- tions, and paralysis. The last, unlike that observed in lead- poisoning, usually involves the extensors of the legs, but later it may also involve the arms. Treatment.—Removal from the influence of arsenic. Tonics. Electricity and massage to the affected muscles. DISEASES OF THE SKIN AND ITS APPENDAGES. THE COLOR OF THE SKIN. Pallor as a permanent condition is generally an expression of anemia; but it should be borne in mind that in some cases the surface is pale when the blood is normally rich in corpus- cles and hemoglobin ; and that in other cases the surface has a natural color when the blood is considerably deficient in corpuscles and hemoglobin. It follows therefore that an abso- lute diagnosis of anemia must rest on an analysis of the blood. Pallor as a temporary condition may result from emotional excitement, exposure to extreme cold, shock, syncope, or coir lapse. Yellowness Of the Skin may result from jaundice, in which case the conjunctive will also be yellow and the urine will contain bile. Yellowness may also result from chlorosis or pernicious anaemia, and in these cases the normal color of the conjunctive, the associated symptoms of the disease, and the absence of bile in the urine will indicate the cause. Whiteness of the Skin.—A milk-white hue over extensive areas may be observed in albinism, vitiligo, and in leprosy. Dark-brown or gray discoloration of the skin is observed in the following conditions :— Addison's Disease.—In this affection the skin has a bronzed appearance, which is especially marked on exposed parts ; the (414) THE COLOR OF THE SKIN. 415 buccal mucous membrane may also reveal discolored plaques; and there are in addition anemia, prostration, and gastric irritability. Argyria.—This term is applied to the dark-gray discolora- tion of the exposed parts which follows the prolonged use of nitrate of silver. The discoloration is due to a deposition of the oxide of silver, and is more or less permanent. It is said to be preceded by a dark line on the gums, similar to the one observed in chronic lead-poisoning. Formerly, when nitrate of silver was used extensively in the treatment of epilepsy, it was not an uncommon condition. Vagabondismus.—This term is applied to the dark-brown discoloration of the skin which follows prolonged exposure to the weather, uncleanliness, and perhaps the irritation of the skin resulting from pediculosis. Blueness of the skin, as a permanent condition, is generally an expression of cyanosis. Hardness, or Induration of the Skin. Induration of the skin is observed in scleroderma. In this affection the skin is tense, hide-bound, and more or less pig- mented. Induration is also observed in myxoedema. In this condition the skin is swollen as in edema, but it is firm, in- elastic, and does not pit on pressure. In addition, the features are peculiarly broadened and the mental power is impaired. Circumscribed patches of induration are observed in morphoea. The circumscribed patches, with hyperemic or pigmented borders, and the smooth, shiny, atrophied skin are the diag- nostic features. (Edema, or dropsy of the subcutaneous tissues, when extreme, also causes induration. A brawny, indurated condition of the muscles, especially of the legs, is frequently observed in scurvy. It probably results from a sanguineous exudation. The anemia, purpuric spots, and spongy, bleeding gums will aid in the diagnosis. 416 DISEASES OF THE SKIN AND ITS APPENDAGES. 03DEMA, OR DROPSY OF THE SUBCU- TANEOUS TISSUES. Oedema may be recognized by a swelling which pits on pressure. It results from : (1) Venous stasis—from chronic heart, liver, and lung disease; and from local obstruction to the venous circulation, as by a tumor, pregnant uterus, or a varicose condition of the veins. (2) Alterations in the blood or capillaries, as in Bright's disease, anemia, and inflammation. GLOSSY SKIN. " Glossy Skin."—This term was applied by Paget to indi- cate a smooth, atrophied, and shiny appearance of the skin. It is most frequently observed after inflammation or injury of the nerve-trunks. It is sometimes associated with an intense burning pain, to which Mitchell has given the name causalgia, ENLARGEMENT OF THE SUPERFICIAL VEINS. Enlargement of the superficial veins may result from chronic heart, lung, or liver disease; from the pressure of a tumor or aneurism on deep-seated veins; or, as a general con- dition, it may be congenital and result from occlusion of deep veins. " Caput Medusas."—This term is applied to a circle of dilated veins surrounding the umbilicus. It is indicative of obstruc- tion to the portal circulation, and may result from atrophic cirrhosis of the liver, from thrombosis of the portal vein, or from the pressure of a tumor on the portal vein. CUTANEOUS EMPHYSEMA. Cutaneous emphysema consists in an escape of air into the cellular tissue. It is manifested by a diffuse, pallid swelling of the skin, which crackles on palpation and which pits on pressure; but, unlike edema, the depression immediately dis- appears when the finger is withdrawn. It may result (1) from CUTANEOUS ERUPTIONS. 417 traumatism of the air-passages, as a gunshot wound of the chest or a fracture of the rib. (2) From rupture of the esophagus, stomach, intestines, larynx, trachea, or lungs. The rupture of these organs is usually due to ulceration, as in cancer of the esophagus, tuberculous cavity of the lung, or purulent pleurisy; but occasionally the lung ruptures from violent strain. ABNORMAL CONDITIONS OF THE NAILS. Atrophy of the Wails.—The nails may become dry, brittle, discolored, and cracked in organic disease of the spinal cord; after inflammation or injury of the peripheral nerves; after prolonged febrile diseases, like typhoid fever; and in certain affections of the skin which involve the matrix of the nail, as eczema, psoriasis, and ringworm. Curving Of the Nails.—Incurvation of the nails is generally associated with clubbing of the terminal phalanges. It is ob- served in phthisis, chronic cardiac disease, and in many wast- ing diseases. Onychia.—Inflammation of the matrix of the nail may re- sult from injury; from syphilis; from organic disease of the spinal cord, as locomotor ataxia; from arthritis deformans; and from cutaneous affections involving the matrix, as leprosy, ringworm, and eczema. CUTANEOUS ERUPTIONS. Macules. Macules are discolored spots which are neither elevated nor depressed. A general red macular eruption is observed in the following conditions :— Syphilis.—Secondary syphilis may manifest itself as an eruption of small red macules. They are usually abundant and frequently cover the entire body; they lack subjective symptoms; they are usually associated with the history or with the evidences of syphilis, such as the scar of the chancre, bone-pains, alopecia, swollen glands, and sore throat. 27 418 DISEASES OF THE SKIN AND ITS APPENDAGES. Erythema Multiforme may manifest itself as a macular eruption, but the macules are usually associated with dark-red papules or tubercles. The multiformity of the lesions; their preference for the extremities ; their appearance in successive crops; the short duration of each lesion ; the absence of sub- jective phenomena, such as itching and burning ; and the presence of rheumatic pains are the diagnostic features. Pityriasis rosea.—The eruption is especially found on the trunk ; the lesions are rose-red in color; they are slightly scaly, the scales being dry; subjective phenomena are gener- ally absent; and the duration is a few weeks. Pediculosis Corporis.—Lice may produce a minute red or purple eruption. The small size of the lesions ; their confine- ment to the covered parts ; the intense itching and the presence of scratch-marks ; and the discovery of pediculi on the clothes are the diagnostic features. Rotheln.—This affection produces a macular or maculo- papular rash which disappears in two or three days by slight desquamation. The moderate fever, sore throat, swollen cervical glands, and history of contagion will assist in the diagnosis. Accidental Rashes.—Local inflammation like tonsillitis and acute gastritis, and certain drugs and foods occasionally pro- duce a macular rash. Purpuric spots, or hemorrhagic macules (petechie), result from minute extravasation of blood into the skin. A purpuric eruption is observed in the following condi- tions :— Purpura Haemorrhagica (Morbus Maculosus Werlhofii).— This affection occurs especially in children ; it is associated with fever and bleeding from the mucous membranes; and generally runs a course of one or two weeks. Scurvy.—This disease results from a deprivation of fresh vegetables, and is associated with spongy, bleeding gums, great weakness, and a brawny induration of the muscles. Rheumatism.—Occasionally an eruption of purpuric spots appears in rheumatic subjects. It is usually associated with pains in the limbs, but fever is generally absent.. CUTANEOUS ERUPTIONS. 419 Peliosis Rheumatica (Schbnlein's Disease).—This is an acute affection characterized by purpuric spots, urticaria, sore throat, moderate fever, and an inflammation of the joints resembling rheumatism. By some the disease is regarded as a manifesta- tion of rheumatism. Extreme Anasmia.—A petechial rash is not uncommon in pernicious anemia, leucocythemia, cancer, and advanced Bright's disease. The history and the associated symptoms of the original disease will indicate the diagnosis. Certain Infectious Diseases___In typhus fever a purpuric eruption appears on the fourth or fifth day. In cerebro- spinal meningitis the eruption is frequently petechial. In malignant measles and malignant smallpox the rash is often hemorrhagic. In acute yellow atrophy of the liver and in ulcerative endocarditis a petechial eruption is frequently observed. Poisoning from Certain Substances___Poisoning from phos- phorus, the virus of venomous snakes, mercury, and antipyrin may be associated with an eruption of purpura. Pediculosis and Kindred Affections___Body-lice, bed-bugs, and fleas produce petechial lesions which are surrounded by slight areole. The itching, scratch-marks, and discovery of the parasite are the diagnostic features. Brown macules are observed in :— Lentigo, or Freckle.—The spots are small, and are found especially on exposed parts—face, neck, shoulders, and hands. Chloasma.—Dark spots may result from irritation of the skin from the action of chemicals, heat, scratches, or blisters. They are sometimes noted in general diseases like Addison's disease and syphilis. They also occur in primary affections of the skin, as vitiligo, morphea, scleroderma, and leprosy. Moles, or Naevus Pigmentosa.—These consist in congenital deposits of pigment on various parts of the body. White or pale yellow macules are observed in :— Vitiligo.—Apart from the absence of pigment, the skin is normal in appearance and function. An excess of pigment is generally noted at the periphery of the white patches. Leprosy.—In this condition there are structural changes in the skin and anesthesia in addition to the white appearance. 420 DISEASES OF THE SKIN AND ITS APPENDAGES. Morphffia.— In the late stage of this affection the circum- scribed patches are white or yellow. The structure of the skin is altered, and the periphery of the patches is distinctly hyperemic. Facial Hemiatrophy.—The onset of this disease may be marked by the appearance of a yellow or white spot on one side of the face. Diffuse Erythema or Inflammation of the Skin. Diffuse erythema or inflammation of the skin may result from :— The Action of Certain Drugs (Dermatitis Medicamentosa).— Belladonna, quinine, chloral, cubebs, salicylic acid, and arsenic may produce a diffuse red rash. Scarlet Fever.—The history of contagion, high fever, sore throat, swollen glands, rapid pulse, and the punctiform charac- ter of the rash will indicate the diagnosis. Rotheln.—In some cases of rotheln the eruption is red and diffuse. The history, slight fever, slight catarrh, and marked swelling of the post-cervical glands will suggest rotheln. Local irritation from traumatism, excessive heat, poisonous plants or drugs. Erythema Intertrigo.—This occurs where two cutaneous surfaces come in contact. The part is red, moist, and some- times macerated. The condition excites a burning pain. Eczema.—The skin is thickened and infiltrated; there is marked itching; the redness shades off gradually ; and there is no fever. Erysipelas.—The part is considerably swollen ; the redness and swelling terminate in au abrupt ridge ; and the tempera- ture is high. Acne Rosacea.—This is a chronic disease; the redness appears on the face, and is associated with acne lesions and dilated capillaries. Vesicles. A vesicle is a small elevation of the skin, containing serous fluid, and varying in size from a pinhead to a split-pea. Vesicles are observed in the following conditions :— CUTANEOUS ERUPTIONS. 421 Sudamen.—This consists of an eruption of minute vesicles which result from the imprisonment of sweat in the layers of the skin. It is usually associated with free perspiration ; the vesicles are translucent, lack inflammatory characteristics, and show no tendency to rupture. Herpes.—The vesicles appear in groups or clusters ; they are mounted on an inflammatory base; they show no tendency to rupture; they are frequently associated with burning or neuralgic pains; and they are distributed along the line of the nerve-trunks. Dermatitis Venanata.— A vesicular eruption may result from contact with poisonous plants, such as the poison ivy or oak. The eruption generally appears on the exposed parts— face or hands; the part is red and swollen and there is intense itching. Dermatitis Herpetiformis.—The vesicles are very irregular in shape; they appear in clusters; they are very tense; they show no tendency to rupture ; they are frequently associated with other lesions—papules, pustules, and bulle; they excite intense itching ; and they appear in crops over a period of weeks or months. Impetigo Contagiosa.—The eruption consists of small vesi- cles which subsequently enlarge until they reach the size of blebs; the vesicles appear in crops; are commonly discrete ; are flat and umbilicated ; are filled with a straw-colored fluid ; they show no tendency to break, but dry up and form thin yellow crusts, and they excite but little itching. The disease is contagious and auto-inoculable ; occurs especially in chil- dren ; and lasts from one to two weeks. Vesicular Eczema.—The vesicles are quite small and are aggregated in patches; the intervening skin is red and thick- ened ; the vesicles tend to break and pour forth a serous fluid which keeps the part moist; and the eruption is associated with intense itching. Miliaria, or Heat-rash.—This may appear as an eruption of minute vesicles; they are alway discrete ; they are sur- rounded by red areole; they usually appear on the trunk; they are generally associated with pin-head papules; they 422 DISEASES OF THE SKIN AND ITS APPENDAGES. show no tendency to rupture ; and they excite a little burning and itching. Scabies.—In this affection the vesicles are small; they are usually associated with pustules and burrows; they excite in- tense itching; and they are usually found on the hands, fore- arms, in the axille, under the mamme, and on the inner aspects of the thighs. Blebs, or Bullae. A bleb, or bulla, is a circumscribed elevation of the skin, containing serous fluid, and varying in size from a pea to an egg. Blebs are observed in the following conditions :— Impetigo Contagiosa.—The blebs are flat and umbilicated ; they contain a straw-colored fluid ; they appear in crops ; they are commonly discrete; they show no tendency to break, but dry up and form thin yellow crusts; and they excite but little itching. The disease is contagious and auto-inoculable ; occurs especially in children ; and lasts from one to two weeks. Dermatitis Herpetiformis—The bulle are frequently asso- ciated with papules, vesicles, and pustules; they are surrounded by inflamed skin; they appear in clusters; they show no tendency to break, but dry up and leave yellowish-brown crusts; and they excite considerable itching. Pemphigus.—The bulle appear in crops; excite but little itching; they lack an inflammatory areola; and as a rule they dry up, and leave behind a thin pellicle. The disease is generally chronic. Syphilis.—The bullous syphilide is observed in hereditary syphilis, and very late in the acquired disease. The contents of the bulle soon become pustular; the blebs dry up, and form dark-green, cone-shaped, stratified crusts, which become detached and leave discharging ulcers. The history and the other evidences of syphilis will aid in the diagnosis. Pustules. A pustule is a small circumscribed elevation of the skin containing pus. Pustules are observed in the following dis- eases :— CUTANEOUS ERUPTIONS. 423 Eczema Pustulosum___The pustules are small; are aggre- gated in a patch; are generally associated with minute vesicles; the intervening skin is red and thickened; and there are marked burning and itching. Acne Vulgaris.—The pustules are usually confined to the face, back, and shoulders; they have their origin in the sebaceous follicles ; they are generally associated with papules and comedones; and they excite no itching. Dermatitis Herpetiformis.—The pustules are frequently associated with papules and vesicles ; they are surrounded by inflamed skin ; they appear in clusters; and they excite con- siderable itching. Impetigo Simplex.—This affection is usually observed in children ; the pustules are round, and range in size from a pea to a cherry ; there is only a slight red areola, and this finally disappears; the pustules remain discrete; they show little tendency to rupture, but dry up and form yellowish- brown crusts; they are mostly observed on the extremities; they excite no itching. The disease lasts from a few days to a week. Impetigo Contagiosa.—The eruption is at first vesicular, but it soon becomes pustular; the pustules vary in size from a pea to a large marble; they are flat and umbilicated ; they appear in crops ; they are commonly discrete ; they show no tendency to break, but dry up and form thin yellow crusts; and they excite but little itching. The disease is contagious and auto- inoculable; occurs especially in children; and lasts from one to two weeks. Varicella, or Chicken-pox.—The pustules result from vesi- cles ; they appear especially on the trunk ; they are small and not umbilicated; they excite but little itching. There is some fever. The disease lasts but three or four days. Ecthyma.—This disease is observed especially in poorly- nourished adults. The pustules vary in size from a pea to a cherry; they are few in number; they are mounted on an inflammatory base, and are surrounded by a distinct inflam- matory areola ; they 'excite but little itching; they seldom break, but dry up and form brownish crusts. 424 DISEASES OF THE SKIN AND ITS APPENDAGES. Smallpox.—In this disease shot-like papules and umbili- cated vesicles precede or are associated with the pustules. The-. latter are small, surrounded by a red areola, and usually excite v^ some itching. The high fever and history of contagion will assist in making the diagnosis. Syphilis.—The pustules are frequently associated with other lesions; they are often mounted on a copper-colored inflamma- tory base; they excite no itching; and they are usually asso- ciated with the history and the other evidences of syphilis. Scabies.—The pustules are small and usually associated with papules, vesicles, and burrows; they are especially ob- served on the hands, forearms, in the axille, under the mam- me, and on the inner aspects of the thighs, and they excite considerable itching. There is often a history of contagion. Papules. A papule is a circumscribed solid elevation of the skin varying in size from a pin-head to a uea. Papules are ob- served in the following conditions :— Erythema Multiforme—The papules are often associated with macules and tubercles ; they are flat, and are of a bright- r.ed or purple color; they appear especially on the extremities; and they show no tendency to suppurate, but gradually disap- pear in the course of two or three weeks; they excite no itching, but they are often associated with prostration and rheumatic pains. After the Use of Certain Drugs.—Bromides, iodides, copaiba, cubebs, and tar may produce a papular eruption. The history will aid in the diagnosis. Eczema Papulosum—The papules are very small, closely aggregated, and often associated with vesicles and pustules; the skin is thickened ; and there is intense itching. Miliaria, or Prickly Heat.—The papules are very small ; they are very often associated with minute vesicles; they always remain discrete; they appear especially on the trunk ; and they excite a little burning and itching. Acne Vulgaris.—The papules are usually confined to the face, back, and shoulders; they are generally associated with CUTANEOUS ERUPTIONS. 425 pustules and comedones; they involve the sebaceous follicles; and they do not excite subjective symptoms. Scabies.—The papules are small and are usually associated with pustules, vesicles, and bur rotes; they are especially ob- served on the hands, forearms, in the axille, under the mam- me, and on the inner aspects of the thighs; and they excite considerable itching. There is often a history of contagion. Syphilis.—The papules are dark in color; they are widely distributed, being especially marked on the trunk and flexor surfaces of the extremities; they are usually associated with pustules; and they excite no itching. The history and the accompanying evidences of syphilis will aid materially in establishing the diagnosis. Smallpox.—The papules are hard and have a shot-like feel; they soon terminate in umbilicated vesicles; they excite some itching, and they are associated with high fever, pain in the back, and often a history of contagion. Measles.—The papules are small, and run together to form crescentic-shaped patches ; and they are associated with mod- erate fever, swollen cervical glands, coryza, conjunctivitis, and bronchitis. There is often a history of contagion. Tubercles. Tubercles are large, circumscribed, solid elevations of the skin varying in size from a large pea to a walnut. They are observed" in the following conditions:— Erythema Nodosum.—The tubercles are large; they usually appear on the extremities; they are reddish-purple in color; they never suppurate; and they are associated with malaise, fever, and rheumatic pains. Erythema Multiforme.—The tubercles are generally asso- ciated with macules and papules; they are flat, and are of a bright-red or purple color; they appear especially on the ex- tremities, and they show no tendency to suppurate, but gradu- ally disappear in the course of two or three weeks. ^ They excite no itching, but are often associated with prostration and rheumatic pains. The disease is probably allied to erythema nodosum- 426 DISEASES OF THE SKIN AND ITS APPENDAGES. Lupus Vulgaris.—This may begin as a papule or tubercle. It is especially observed on the face. The tubercles are of a pale-red color and are quite soft to the touch. As a rule, they slowly break down and form shallow ulcers with soft red margins. The ulcers are painless and secrete but little ma- terial. They may invade all of the soft structures, but the bones escape. Syphilis.—The tubercular syphilide manifests itself as dark- red tubercles. There are seldom more than three or four, and they generally appear on the face and extremities. They are very firm, and often break down, forming deep, punched-out ulcers which secrete an abundant purulent material. Tinea Sycosis, or Barber's Itch.—The tubercles appear on the hairy parts of the face and involve the hair-follicles. Sup- puration soon begins in the centre of the tubercles, and the hairs become dry, brittle, and loose. The microscope will re- veal the tricophyton. Leprosy.—One form of leprosy manifests itself as tubercles. The latter are of a pale-red or yellow color, and undergo slow absorption or ulceration. There is usually more or less anes- thesia in the parts affected. Wheals, or Pomphi. Wheals are evanescent elevations of the skin, generally more or less round, and often white in the centre and pale-red at the periphery. They excite considerable itching. They are observed in the following conditions :— Urticaria.—The wheals appear in crops ; they are of very short duration; they may appear on any part of the body ; and they excite intense itching. Erythema multiforme, peliosis rheumatica (Schonlein's dis- ease), and certain insects like mosquitoes also produce wheals. Crusts. Crusts consist in dried exudation, and may be red, yellow, brown, or green in color. They are marked in the following diseases:— CUTANEOUS ERUPTIONS. 427 Eczema.—The crusts are generally associated with pustules and vesicles ; the surrounding skin is red and thickened ; and there is considerable itching. Seborrhoea.—Crusts of seborrhoea are generally observed on the scalp. Itching is absent, and there are no evidences of inflammation. Syphilis.—The crusts are thick; they are of a dark-brown or green color; and they are often associated with ulcers which freely discharge. The history and other evidences of syphilis will aid in the diagnosis. Impetigo.—The crusts are thin and yellow; and they are associated with blebs which appear in crops. Favus.—The crusts generally appear on the scalp ; they are yellow, brittle, and cup-shaped; they are usually perforated by a hair, and have a peculiar musty odor. Tinea Tonsurans, or Ringworm of the Scalp.—In neglected cases this affection may be associated with crusting. It is only observed in children. The grayish scales, the dry, brittle, and broken hairs projecting through the crusts, the alopecia, and the detection of the tricophyton are the diagnostic features. Scales. Scales are dry exfoliations from the upper layers of the skin. They are observed in the following diseases :— Squamous Eczema.—The scales are usually associated with papules ; the underlying skin is red and thickened ; and there is often marked itching. Seborrhoea Sicca.—The scales are greasy, and the under- lying skin shows no evidence of inflammation. The sebaceous follicles are often dilated. Psoriasis.—The scales are dry, and are of a pearly-white color ; they are associated with circumscribed, sharply-defined, elevated inflammatory patches. The extensor surfaces are especially involved. There is little or no itching. Ichthyosis.—This affection begins in early life. The scales are dry, and are especially marked on the extensor surfaces. Itching is absent, and there is no evidence of inflammation. 428 DISEASES OF THE SKIN AND ITS APPENDAGES. Syphilis.—The scales are dry, and are of a grayish color ; they are usually associated with papules; and they are espe- cially marked on the palms and soles. There is no itching. The history and other evidences of syphilis will assist in the diagnosis. Pityriasis Rosea.—The scales are found especially on the trunk, and are associated with small, rose-red macules. There is no itching. The disease runs an acute course of a few weeks' duration. Ringworm.—The scales are dry and scant; they are associ- ated with circumscribed red patches which tend to disappear in the centre. There is often marked itching. Microscopic examination reveals the tricophyton. Ulcers. Ulcers are observed especially in the following diseases :— Syphilis.—The ulcers are deep; they have a punched-out appearance; they secrete an abundant offensive material; they often involve the bone; they extend rapidly; they are not painful, and the imperfect cicatrix which they produce is soft. The history and other evidences of syphilis will aid in the diagnosis. Epithelioma.—This appears in late life; there is usually a single centre of ulceration ; the ulcer is irregular in shape; the edges are thickened and infiltrated; the secretion is scanty and bloody; the progress is somewhat slow, and there is often pain. Lupus Vulgaris.—This generally appears in early life; there are often several centres of ulceration; the ulcers are usually superficial; the edges are not thickened; the progress is ex- tremely slow; the bones are never involved; there is very little secretion, and soft papules often develop in the cicatrix, which is firm and contracted. Simple Ulcers may result from traumatism, the application of caustics, or the action of intense heat or cold. Ulcers are frequently observed on the legs of old people in association with varicose veins. Simple ulcers may be recognized by the history, location, appearance, and the absence of other causes. CUTANEOUS ERUPTIONS. 429 Perforating Ulcer of the Foot.—This term is applied to a deep-seated ulcer appearing oh the sole of the foot and most frequently observed in locomotor ataxia. It usually begins as a corn in the neighborhood of the great toe, and is generally associated with anesthesia of the sole of the foot. Decubitus.—This term is applied to the bedsores which form after the occurrence of grave cerebral or spinal lesions. They are generally observed on parts which are subjected to pressure, as the sacrum, buttocks, calves, and heels, and are preceded by erythema and vesication. 430 DISEASES OF THE SKIN AND ITS APPENDAGES. DISEASES OF THE SWEAT-GLANDS. Anidrosis. Definition.—A deficiency of sweat. Etiology.—It may be a symptom of some general disease, like diabetes or Bright's disease; it may be an associated con- dition in certain cutaneous diseases, such as ichthyosis or psori- asis ; and it may develop without obvious exciting cause as a result of disturbed innervation. Treatment.—Remedies should be directed to the primary disease. Hyperidrosis. Definition.—Excessive sweating. Etiology.—As a general condition it is often observed in phthisis and in other diseases characterized by marked de- bility. Local hyperidrosis is most frequently observed in the hands, feet, and axille, and probably results from some de- rangement of the sympathetic nervous system. Unilateral sweating of the face may indicate an aneurism or tumor pressing on the cervical sympathetic. Symptoms.—The primary symptom is excessive sweating, and this often leads to intertrigo or eczema. Bromidrosis is often associated with the hyperidrosis. Prognosis.—Guarded. In many cases the condition is very obstinate. Treatment.—Frequently there is an evident impairment of the general health which will require appropriate treat- ment. Internally, one of the following remedies may be em- ployed to diminish the amount of sweat: Belladonna, picro- toxin, agaricin, or ergot. Local Treatment.—Dusting-powders of starch, talc, or lyco- podium with boric or salicylic acid; or lotions containing sulphate of zinc, tannic acid, or alum, are often very useful. fy Pulv. acid, salicylic, Pulv. zinci carb. praecip., Pulv. magnesii ustse, aa 31V ; Pulv. amyli, jxv; Pulv. talci, 3xx.— M. (Habdaway.) Sig. —Dusting-powder. diseases of the sweat-glands. 431 In hyperidrosis of the feet the method suggested by Hebra is often very efficient. The feet should be washed, thoroughly dried, and then carefully enveloped in strips of muslin which have been spread with diachylon ointment. The application should be made twice daily. In the dressing no water should be employed, but the feet must be carefully wiped and then dusted with starch or lycopodium before the ointment is re- applied. The treatment should be continued for from one to two weeks, after which the feet may be washed and the dust- ing-powder alone used Bromidrosis. (Osmidrosis.) Definition.—A functional affection characterized by the excretion of sweat which has a fetid odor. Symptoms.—It is generally local and often confined to the feet; it is frequently associated with hyperidrosis. Treatment.—Same as hyperidrosis. Chromidrosis. Definition.—A functional affection characterized by the secretion of colored sweat. Symptoms.—The parts most frequently affected are the face and trunk; the most common colors are red and yellow. It is often associated with hyperidrosis. Sudamen. Definition.—A cutaneous affection characterized by the eruption of minute vesicles resulting from the retention of sweat in the layers of the skin. Etiology.—It is often observed in health in persons who perspire freely. It is frequently noted in febrile diseases which are associated with sweating, like pneumonia and typhoid fever. Symptoms.—Minute, irregular, translucent vesicles appear on the surface. They are not surrounded by an inflammatory 432 DISEASES OF THE SKIN AND ITS APPENDAGES. areola. They do not rupture, but dry up and are followed by slight desquamation. Treatment.—The affection has little significance and treat- ment is rarely required. FUNCTIONAL DISEASES OF THE SEBACEOUS GLANDS. Seborrhoea. (Steorrhcea.) Definition.—A functional affection characterized by ex- cessive secretion of sebaceous material which may be normal or perverted. Etiology.—In many cases the cause is not apparent. Often the disease is associated with impairment of the general health. By some it is regarded as of parasitic origin. Varieties.—Seborrhea sicca and seborrhea oleosa. Seborrhoea Sicca.—This form is most frequently observed on the scalp and constitutes what is popularly termed dan- druff. Examination reveals an incrustation composed of thin, yellowish-gray, greasy scales. In uncomplicated cases the skin is pale, but from irritation it may subsequently become hyperemic or inflamed. When allowed to continue, the nutrition of the hair is interfered with and baldness results. On the body seborrhea sicca appears as yellowish-gray slightly elevated patches covered with greasy scales. The out- lets of the follicles are often dilated. There is generally more or less redness of the skin from hyperemia (seborrheal eczema.) Seborrhoea Oleosa.—This form is most commonly observed on the face, particularly about the nose, which is habitually bathed in an oleaginous material which has exuded from the sebaceous follicles. From irritation the parts are often red. The condition is frequently associated with seborrhea sicca, comedo, and acne. Diagnosis. Eczema.—In this disease the skin is red and thickened ; there is marked itching; and the scales are not greasy. COMEDO. 433 Psoriasis.—In this disease the scales are dry and pearly and there are evidences of inflammation. Prognosis. — Favorable under prolonged and judicious treatment. Treatment—The general health may be impaired ; hence tonics like iron, strychnia, and cod-liver oil are often indicated. The gastro-intestinal tract will often require especial atten- tion. Constipation should be relieved by diet, enemata, or mild laxatives. Local Treatment,—Crusts should be removed by applications of oil, followed by shampooing with alcohol and green soap. When the scalp is thoroughly clean, one of the following remedies may be applied : Sulphur, mercury, tar, carbolic acid, or resorcin. ty. Sulphur, loti, gij ; Balsami Peruviani, sjss; Yaselini, ^x.—M. (G-. H. Fox.) Sig.—After bathing the part apply the ointment. Or— I$l Acid, carbolic, TTLxxx ; Olei ricini, f gij ; Alcoholis, f3j-3yj.— M. (Duhring and Stelwagon. ) Sig.—Fill an eye-dropper, introduce between the hairs, and sub- sequently rub in by means of a flannel rag. Mild cases of facial seborrhea often yield to the following ointment:— $. Hydrarg. chlor. mit., gr. xx; Ung. zinc, oxid., ^j.—M. Sig.—Apply at bedtime. COMEDO. Definition.—A functional disease of the sebaceous glands, characterized by the retention of discolored sebaceous material in the distended ducts of the gland. Etiology.—It is most frequently observed in young adults. Debility, gastro-intestinal disorders, anemia, and lack of cleanliness are predisposing factors. 28 434 DISEASES OF THE SKIN AND ITS APPENDAGES. Pathology.—The material in the ducts is composed of sebum, altered epithelium, and pigment matter which is prob- ably derived from without. Microscopic examination of the material often reveals a mite—the demodex folliculorum—but its presence is accidental and of no etiological significance. Comedo is generally associated with seborrhea. Symptoms.—The disease is characterized by an aggregation of minute black or yellowish spots which correspond to the outlets of the sebaceous glands. The lesion is often slightly elevated, and when the skin is squeezed a white filiform mass exudes, to which the term " flesh-worm" has been popularly applied. The parts most commonly affected are the face, back, and ears. The condition frequently excites an inflammation of the follicles, hence it is often associated with acne. Prognosis. — Favorable under persistent and judicious treatment. Treatment.—Anemia, dyspepsia, and constipation must be treated by a careful regulation of the personal hygiene, and by the use of appropriate remedies. Tonics like iron, quinine, cod-liver oil, and strychnia are often indicated. Local Treatment. — Large plugs may be pressed out by means of a watch-key or a special instrument for the purpose. Softening and removal of smaller plugs may be hastened by the application of cloths wrung out in very hot water. Kneed- ing and the application of alcohol and green soap will also assist in their expulsion. Mercury and sulphur are useful remedies. ty. Hydrarg. chlor. corros., gr. iv; Alcoholis, f Jj ; Aque rose, q. s. ad fgiv.—M. Sig.—Dab on twice daily. MILIUM. (Grutum.) Definition.—An affection characterized by the appearance of small, pearly, non-inflammatory elevations, which result from the accumulation of inspissated sebum in ducts, the out- lets of which have been occluded. steatoma—erythema simplex. 435 Symptoms.—It is generally observed about the face, and consists of a collection of small, round, pearly elevations, which vary in size from a pin-head to a small pea. The contents of the distended duct cannot be squeezed out until an opening is made, and thus it differs from comedo. It is frequently asso- ciated with comedo and acne. Treatment.—Incise the lesion, express the contents, and treat as in seborrhea. STEATOMA. (Wen.) Definition.—A steatoma, or wen, is a cyst resulting from the retention of secretion in a sebaceous gland. Symptoms.—One or more rounded or oval elevations, vary- ing in size from a pea to a large walnut, slowly appear on the scalp, face, or back. They are painless, rather soft, and when opened are found to contain a yellowish-white caseous mass. Diagnosis. Fatty Tumors.—Fatty tumors are rare on the scalp; they are frequently lobulated ; they have a doughy feel; and are not so movable as wens. Treatment.—The sack and its contents should be carefully dissected out. Simple excision and evacuation are always fol- lowed by a return of the cyst. ERYTHEMA SIMPLEX. Definition.—Active hyperemia of the skin. Etiology.—It may result from exposure to heat or cold; from traumatism ; or from the application of some irritating substance. A symptomatic variety is frequently observed in gastric irritation and systemic diseases. Symptoms.—Diffuse uniform redness, disappearing on pres- sure, and without thickening or elevation of the skin. When it is marked, there may be slight burning. Treatment.—Sedative lotions or dusting-powders. 436 DISEASES OF THE SKIN AND ITS APPENDAGES. ERYTHEMA INTERTRIGO. (Chafing.) Definition.—Hyperemia induced by the attrition of op- posing surfaces of the skin. Etiology.—It is common in children and in fat subjects. It is especially noted where there are friction and perspiration, as under pendulous mamme, between the upper parts of the thighs, and around the genitalia. Symptoms.—It is characterized by diffuse redness, and often by heat and moisture. It excites a burning sensation. When the cause is continued it may result in dermatitis. Treatment.—Apply a lotion of boric acid and follow with a dusting-powder. ERYTHEMA NODOSUM. (Dermatitis Contusiformis.) Definition.—An acute inflammatory disease, characterized by crops of large bright-red nodes which in the process of evo- lution assume different colors as in the fading of a*bruise. Etiology.—Unknown Symptoms.—There is a sudden eruption of bright-red nodes varying in size from a pea to an egg. The extremities are most commonly affected. The advent is marked by malaise, headache, slight fever, and rheumatoid pains. At first the lesions resemble boils, but unlike the latter, they do not suppurate, but gradually turn yellow, blue, and green as a bruise. Prognosis.—Favorable. Duration a few weeks. Treatment.—Iodide of potassium and alkalies have been recommended. Locally, lead-water and laudanum make a soothing application. ERYTHEMA MULTIFORME. Definition.—An inflammatory disease characterized by erythematous, papular, vesicular, or bullous lesions. URTICARIA. 437 Etiology.—It is more common in women than in men. It is apt to develop in the spring or fall. Rheumatism and gastro-intestinal disturbances seem to predispose. Symptoms.—It is marked by an eruption, usually on the extremities, of the following lesions : macules, papules, vesicles, or bulle. The lesions may aggregate or remain discrete; they last one or two weeks and gradually fade. There is little or no itching. In some cases there is decided constitutional dis- turbance, manifested by malaise, headache, slight fever, and rheumatic pains. Diagnosis. Dermatitis Herpetiformis. — The marked itching, the greater tendency for the lesions to cluster, and the chronic character of dermatitis herpetiformis will usually pre- vent an error in diagnosis. Urticaria.—In this disease the individual lesions last a very short time and are associated with marked itching. Prognosis.—Favorable. Duration a few weeks. Treatment.—In the debilitated iron and quinine are useful. In the rheumatic, the salts of lithium and of potassium may be employed. Constipation should be relieved by saline laxa- tives. Locally, lotions of boric or carbolic acid followed by dusting-powders exert a beneficial effect. URTICARIA. (Hives, Nettle Rash.) Definition.—An inflammatory affection characterized by the eruption of pale-red, evanescent wheals which are asso- ciated with severe itching. Etiology.— Gastro-intestinal disturbances, emotional ex- citement, and chronic visceral diseases predispose. In some it may be excited by certain articles of food such as shell- fish, strawberries, etc. The bites of certain insects produce the disease, such as mosquitoes, bed-bugs, and caterpillars. Some drugs induce urticaria in susceptible people. Pathology.—The disease consists in a vaso-motor spasm, followed by paresis of the vessels and an outpouring of serum. Symptoms.—There is a sudden general eruption of papules or wheals which is associated with intense itching. Each 438 DISEASES OF THE SKIN AND ITS APPENDAGES. lesion lasts a few hours and is succeeded by new ones in other places. Varieties. Urticaria Papulosa.—In this form the wheal is followed by a lingering papule which is attended by consid- erable itching. It is most commonly observed in debilitated children. Urticaria Hemorrhagica.—The lesions are infiltrated with blood. Diagnosis. Erythema Multiforme and Erythema Nodo- sum.—In both of these affections the lesions last much longer, and are free from itching. Prognosis. — Unfavorable. In some cases it tends to become chronic. Treatment.—The cause should be removed when possible. In gastric irritation bismuth, or calomel and soda are useful. When there is constipation a saline laxative may prove very efficient. The special remedies usually recommended are alka- lies, salicylate of sodium, quinine, iodide of potassium, and atropine. Locally, lotions of water and alcohol, carbolic acid, boric acid, or hydrocyanic acid are very useful: IJl Acid, carbolic, 3j-3ij ; Glycerini, f§ss ; Alcohol., f^vj ; Aque, q. s. ad Oj.—M. Urticaria Pigmentosa. This is a form of urticaria observed in young children. It is characterized by an eruption of wheals which are itchy and persistent, and which leave behind a yellowish or brownish pigmentation. The disease runs a chronic course of months or years. HERPES SIMPLEX. (Fever Blisters.) Definition.—An acute non-contagious disease, character- ized by groups of small vesicles mounted on inflammatory bases. HERPES ZOSTER. 439 Etiology.—Herpes is very common in febrile diseases, especially pneumonia, influenza, malaria, and cerebro-spinal meningitis. Local irritation also predisposes to it. It is de- pendent upon neurotic disturbance. Symptoms.—One or more clusters of small vesicles appear, usually on the face or genitalia. The vesicles are mounted on an inflammatory base, contain clear fluid, and show no ten- dency to rupture, Soon their contents become puriform, dry up, and form reddish-brown crusts which fall off in a few days. Burning and tingling precede and accompany the eruption. Varieties.—When it appears on the face, it is termed herpes facialis ; on the genitals, herpes progenitalis. Diagnosis.—Herpes progenitalis must be distinguished from chancroid. The history, the superficial character of the lesion, the burning pain, and the subsequent course will indi- cate herpes. Treatment.—The lesion may be painted with flexible collodion, or the following lotion employed :— ]£. Zinc, oxid., gr. xv ; Glycerini, 1TL xv; Liq. plumbi subacetat. dil., TTL x ; Liq. calcis, 3vj-gj.—M. (Tilbury Fox.) Sig.—Apply locally. HERPES ZOSTER. (Zona, Shingles.) Definition.—An acute inflammatory disease characterized by groups of small vesicles mounted on inflammatory bases, associated with neuralgic pain, and following the distribution of certain nerve-trunks. Etiology.—The disease commonly depends upon a periph- eral neuritis. Injury, exposure to cold, and damp clothes predispose to it. Symptoms.—Clusters of vesicles mounted on inflammatory bases may appear on any part of the body ; but they are most frequentlv observed along the course of the intercostal nerves. Only one' side is affected. Sharp neuralgic pain precedes and accompanies the eruption. The fluid in the vesicles soon be- 440 DISEASES OF THE SKIN AND ITS APPENDAGES. comes turbid, dries up, and forms yellowish-brown crusts which fall off in a few days. Prognosis.—Favorable. Treatment.—Tonics are often indicated. Bulkley recom- mends phosphide of zinc in doses of one-third of a grain every three hours. Morphia is sometimes required for the relief of pain. Locally.—Sedative applications are required; the best are flexible collodion with morphia, or a solution of menthol or carbolic acid, followed by a dusting-powder of oxide of zinc or starch. T$l Morph. sulph., gr. viij ; Collodii, fjj.—M. Sig.—Apply with a camel's-hair brush. HERPES IRIS. Definition.—An inflammatory disease, characterized by groups of vesicles arranged in concentric rings which present a somewhat variegated appearance. Etiology.—The causes are unknown. The disease is rare. Symptoms.—One or more rings of vesicles successively appear around a central vesicle or papule. The different ages of the rings which compose the patch impart to the latter a variegated appearance. Burning and itching are often atten- dant symptoms. The hands, arms, and feet are the parts most frequently affected. The lesions appear in successive crops over a period of several weeks. In some instances the vesicles are quite large and resemble the blebs of pemiphigus. Prognosis.—Favorable, but recurrent attacks are common. Treatment.—The same as in herpes zoster. ACNE. (Acne Vulgaris.) Definition.—-An inflammatory disease of the sebaceous glands, characterized by papules and pustules and usually seated on the face or back. ACNE. 441 Etiology.—It generally develops about puberty. Anemia, menstrual disorders, and gastro-intestinal disturbances predis- pose. Certain drugs like iodide aud bromide of potassium and copaiba may induce the disease. Pathology.—Acne lesions result from the irritation ex- cited by retained sebaceous matter, hence the papules and pus- tules are commonly associated with blackheads, or comedones. Symptoms.—An aggregation of small papules, pustules, and comedones about the face, chest, and shoulders. Pustules or papules predominate according as the disease is acute or chronic. New lesions develop as the old disappear, so that the disease usually runs a protracted course. Subjective phe- nomena are absent. Varieties. Acne Papulosa.—In this form the lesion reaches the papular stage and advances no further. Acne Pustulosa.—In this variety the papules develop into pustules. Acne Indurata,—The inflammation is deeply seated, the base of the papule or pustule is firm, and the lesion is sluggish. Acne Atrophica.—In this form the lesions are followed by small scars or pits. Acne Ilypertrophica.—In this form there is an overgrowth of connective tissue and the skin becomes thickened. Diagnosis.—The distribution, the chronic character of the affection, the involvement of the sebaceous glands, and the as- sociation with comedones are the diagnostic features which separate acne from all other affections. Prognosis.—Curable under persistent treatment. Treatment.—The general health must be improved. The diet should be nutritious, but easily assimilable; rich food must be prohibited. Constipation should be relieved by mild laxa- tives. In the anemic and debilitated iron, quinine, strychnia, and cod-liver oil are useful remedies. The special drugs which have been recommended are arsenic, ergot, and calx sulphurata. Arsenic is best suited to the sluggish indurated forms ; and calx sulphurata (gr. fa-^ four times daily) to the pustular variety. Local Treatment.—In the acute form mild applications should be employed, like the following calamine lotion :— 442 DISEASES OF THE SKIN AND ITS APPENDAGES. $. Pulv. zinc. oxid., ^iij ; Pulv. calamine, gij ; Glycerini, fgij ; Aque calcis, fjvj.—M. In chronic cases the sebaceous plugs should be removed by a watch-key and the pustules incised. Thorough washing with very hot water and green soap is also advisable. The best local remedies are sulphur, mercury, and resorcin. ]£ Calcis, |ss; Sulphur, sublimat., 3j ; Aque, |x.—M. (Vleminckx ) Evaporate to six ounces and filter. Sig.—Apply at first well diluted and gradually increase the strength. Or— $. Sulphur, precip., £j; Ung. aque rose, Petrolat. moll., aa 3iv.— M. (Van Harlingen.) Sig.—Apply night and morning. Or— IJ. Hydrarg. ammoniat., gr. xx-xl; Ung. aque rose, ^j.—M. Sig.—Use night and morning. Or— IJ. Ammon. sulphoichthyol., Aque destillat., Glycerini, Dextrini, aa 53.—M (Unna.) Sig.—Use locally. ACNE ROSACEA. Definition.—A chronic affection, usually located on the face in the region of the nose, and characterized by marked hyperemia, dilatation of the vessels, overgrowth of tissue, and acne lesions. Etiology.—Anemia, menstrual disorders, gastric disturb- ances, exposure to extremes of temperature, and intemperance are the usual predisposing causes. Symptoms.—The affected area is of a deep-red color; the vessels are dilated; the skin is thickened and lumpy, and FURUNCULUS. 443 acne lesions coexist. In advanced cases the nose may become extremely large and lobulated (Rhinophyma). Subjective phenomena are generally absent. Diagnosis. Lupus Vulgaris.—In this disease there are soft pale-red papules, ulceration, and cicatrization, and no en- largement of the bloodvessels. Prognosis.—Unless the hypertrophy is marked, the dis- ease is curable under protracted treatment. Treatment.—The general treatment is the same as in acne vulgaris. Local Treatment.—Sulphur and mercury are the most reli- able remedies. Vleminckx's solution is very useful. Dilated vessels should be destroyed by electrolysis. Large hypertro- phies may be removed by the knife. FURUNCULUS. (Boil.) Definition.—A miniature dermal abscess. Etiology.—Single boils are usually due to local irritation. Their appearance in crops (Furunculosis) is usually indicative of impaired health. The entrance of pus cocci into the skin is always essential to their production. Diagnosis.—Furuncles must be distinguished from carbun- cles ; the latter are single, large, flattened at their summits, and have multiple openings. Treatment.—In furunculosis the cause should be searched for and, if possible, removed. Tonics like iron, quinine, cod- liver oil, and hypophosphites are often very useful. Calx sulphurata (fa-\ gr. thrice daily after meals) sometimes proves serviceable. A solution of boric acid or of corrosive sublimate may be applied locally. The following paste will often abort them :— Ichthyol, Ung. hydrarg., Ext. belladonne, aa ^j.—M. Sig.—Apply locally and make pressure with strips of adhesive plaster. 444 diseases of the skin and its appendages. CARBUNCULUS (Anthrax.) Definition.—A circumscribed inflammation of the skin and deeper tissues, characterized by a dark-red, painful node which breaks down and evacuates through several apertures. Etiology.—Lowered vitality from any cause predisposes. They are especially common in diabetes. The exciting cause is a special microbe. Symptoms.—A dark-red, painful, flattened node appears surrounded by a dusky-red area of induration. In a week or ten days suppuration begins, and the contents are discharged through several orifices. There is generally marked con- stitutional disturbance. The most common seats are the nape of the neck, back, and buttocks. Prognosis. — Guardedly favorable. Death is not an in- frequent termination in the old and debilitated. Treatment.—Generally tonics like quinine, iron, and whiskey are indicated. Opium may be required to relieve pain. Local Treatment.—In the early stage they may be aborted by a central injection of ten to twenty minims of a 5 or 10 per cent, solution of carbolic acid in glycerine. When not seen until abortion is too late, firm compression may be made by straps applied concentrically, leaving the central orifice free for the discharge of sloughs ; an antiseptic dressing may be applied over the straps. PSORIASIS. Definition.—A chronic inflammatory disease, character- ized by red, scaly, sharply-circumscribed, elevated lesions. Etiology.—Psoriasis usually develops in young adults. Heredity, the gouty diathesis, pregnancy, and lactation seem to predispose. It is as common in the robust as in the debilitated. It is non-contagious. Pathology.—A localized hypertrophy of the rete mucosum associated with inflammation. psoriasis. 445 Symptoms.—Little red spots appear on the body, and gradually grow until they reach the size of a dollar. The lesions are of a dull pink or red color, sharply defined, some- what elevated, surrounded by healthy skin, and covered with abundant dry, pearly, overlapping scales. These scales are readily detached, leaving behind a dry, slightly excoriated surface. The lesions may be uniformly distributed over the entire body, but usually the extensor surfaces are more affected; a symmetrical arrangement is often observed. Itching is slightly or entirely absent. After a variable time the centre of the patch disappears and leaves behind a spot of healthy skin which gradually increases until no trace of the lesion remains. The disease runs a protracted course of months or years, im- proving in the summer and growing worse in the winter. Diagnosis. Eczema.—In this disease the patches are not sharply defined, but shade off gradually into the surrounding skin; there is marked itching; there is usually a decided dis- charge, and healing begins at the periphery instead of at the centre as in psoriasis. Seborrhoea.—In this affection the lesions are usually confined to the scalp and face, while psoriasis is general; the scales are gray and greasy ; the patches are not circumscribed, and lack the inflammatory character of psoriasis. Papulosquamous Syphiloderm.—The history, the associated symptoms of syphilis, the coppery color of the lesions, the scant scaling, the special tendency to involve the hands and soles will render the diagnosis apparent. Prognosis.—The disease disappears under treatment, but relapse generally follows after a longer or shorter period. Treatment.—The general health may require attention. In the gouty alkalies are of value ; and in the anemic iron and cod-liver oil are indicated. Arsenic is often of considerable value; it should be given in small doses cautiously increased. Iodide of potassium (gr. x-xx thrice daily) is sometimes rec- ommended. Local Treatment.—The scales should be removed by alkaline baths before local applications are made. The best local remedies are tar, chrysarobin, salicylic acid, resorcin, sulphur, and ammoniated mercury. 446 DISEASES OF THE SKIN AND ITS APPENDAGES. IJ Acid, chrysophanic., gr. x; Adipis benzoat., |j.—M. Sig.—Apply twice daily. Or— IJ Sulphur, sublimat., 01. cadini, aa ^iv ; Sapon. virid., Adipis, aa gj ; Crete prep., ^ijss.—M. (Wilkinson.) ECZEMA. (Tetter.) Definition.—A non-contagious inflammatory disease of the skin, characterized by multiform lesions—erythema, pap- ules, vesicles, pustules, scales, and crusts—and associated with infiltration, itching, and more or less discharge. Etiology.—It is most common in the young and in the aged. Digestive disturbances, debility, gout, and rheumatism predispose to its development. It may be due to external irritants like cold, heat, the rhus-plant, hard soaps, certain dyes, etc. Pathology.— Congestion and infiltration of the various layers of the skin. Varieties.—E. erythematosum, E. papulosum, E. vesicu- losum, E. pustulosum, E. squamosum, and E. rubrum. Eczema Erythematosum.—This form consists in irregular patches marked by swelling, redness, and slight scaling, and accompanied by itching and burning. The most common seat is the face. Eczema Papulosum,—In this form there is a close aggrega- tion of minute acuminated papules accompanied by severe itching. It is frequently associated with the vesicular variety. The most common seat is the extremities. Eczema Vesiculosum.—This consists in an ill-defined red patch surmounted by minute vesicles, and accompanied by intense itching. The vesicles soon rupture and leave a raw, weeping surface which becomes more or less covered with crusts. In children, it is most common on the face ; in adults, on the extremities. eczema. 447 Eczema PustulOStim (Eczema Impetiginosum).—This consists in an aggregation of small pustules which break and lead to the formation of thick yellowish crusts. Itching is not marked. It is frequently associated with the vesicular variety. It is most commonly observed on the face and scalp of poorly- nourished children. Eczema Squamosum.—In this form there are irregular ill- defined red patches accompanied by considerable scaling. It differs from the erythematous form in the large amount of scaling. Its most common seat is the scalp. When there is a marked tendency to Assuring, as in chap- ping, this form is termed eczema fissum ; and when there is a tendency to the formation of warty excrescences, it is termed eczema verrucosum. Eczema Rubrum (Eczema Madidans).—This is a secondary variety and is recognized by a raw, dark-red, moist surface, more or less covered with thick yellowish-red crusts. The itching may be severe. In children it is frequently noted on the face, and in old people on the extremities. Diagnosis. Scabies.—The history of contagion ; the loca- tion of the lesions—between the fingers, on the wrists, under the mamme, in the axille; and the presence of burrows will i-prjii-»Q^-£k sonnies Psoriasis.— The sharply-defined patches, the dry scaling, the absence of marked itching, the symmetrical distribution, and the predilection for extensor surfaces will indicate psoriasis. Acne Rosacea.—The presence of acne papules and pustules and of dilated bloodvessels, and the absence of itching will distinguish acne rosacea from erythematous eczema. Seborrhoea.—The greasy scales and the absence of itching and of all inflammatory symptoms will indicate seborrhea. Sycosis.__The limitation of the lesions to the hair-follicles of the face and the absence of itching will distinguish sycosis from GCZGHl£l Prognosis.—Generally favorable under persistent and j udi- cious treatment. Treatment. General Treatment.—The health must be improved. Tonics are frequently indicated. In strumous 448 DISEASES OF THE SKIN AND ITS APPENDAGES. children cod-liver oil may be of extreme value. Disturbances of the gastro-intestinal tract are frequently present, and will require appropriate treatment. In the gouty and rheumatic the alkaline mineral waters, colchicum, and the salts of lithium are indicated. Constipation must always receive attention. Of the special internal remedies, arsenic is the most important; it is, however, only indicated in the chronic cases in which bright redness, itching, and weeping are absent. External Treatment.—In acute cases with marked inflam- matory symptoms, soothing applications should be employed. A saturated solution of boric acid may be dabbed on for five or ten minutes, and may be followed by zinc ointment spread on lint; when there is much itching carbolic acid is very useful:— IJ. Acid, carbolic, 3j; Glycerini, ^ij ; Aque, q. s. ad f Jviij.—M. Sig.—Apply locally. The following is also frequently used :— IJ Zinc, oxid., |ss ; Pulv. calamine prep., T)iv ; Glycerini, fgj ; Liq. calcis, f^vij.—M. Sig.—Shake and apply locally. In chronic cases crusts and scales should be removed by soap and water or by :— fy Saponis virid., Jij ; Alcoholis, §j.—M. Sig.—Apply thoroughly and. remove with warm water. The best external applications are salicylic acid, tar, mer- cury, and resorcin :— IJ Acid, salicylic, gr. xx ; Petrolat. moll., 3iv; Amyli, Zinci oxid., aa ^ij.—M. (Stelwagon and Duhring.) Sig.—Apply twice daily. Or— IJ. Hydrarg. ammoniati, gss ; Liq. picis alkalin., 3J ; Ung. aque rose, gj.—M. LICHEN RUBER AND LICHEN PLANUS. 449 Or— IJ 01. cadini, ffss ; Glycerini, fgj ; Ung. diachyli, fgiiss.—M. (Tilbury Fox.) Sig.—Apply locally. LICHEN RUBER AND LICHEN PLANUS. Lichen Ruber.—This is an extremely rare disease, charac- terized by the eruption of small, red, glazed, acuminated papules which show no tendency to coalesce, and which are associated with itching and failure of general health. The disease runs a chronic course, and may prove fatal through exhaustion. Lichen Planus.—This form is characterized by an eruption on the extremities of small, red, flat papules which tend to spread, and by coalescing form dull-red, irregular patches. The latter at first have a smooth and shiny appearance, but later are slightly scaly. There is more or less itching, but no impairment of the general health. As the old lesions disap- pear new ones take their place. Etiology.—These affections are most frequently observed in poorly-nourished, middle-aged males. Treatment.—The general health must be improved by good food and such tonics as iron, strychnia, and cod-liver oil. Arsenic is of considerable value. Locally, ointments of tar or mercury are useful. Lichen Scrofulosis. This is a chronic affection occurring chiefly in children of a strumous diathesis, and characterized by small, pale-red, or salmon-colored scaly papules. They tend to form in groups, and are most frequently observed on the trunk. Itching is absent. The disease runs a chronic course. Treatment.—Ilemedies like iron, quinine, and cod-liver oil are indicated. Hebra recommends the last remedy as a local application. 29 450 DISEASES OF THE SKIN AND ITS APPENDAGES. PRURIGO. Definition.—A chronic inflammatory disease, characterized by a general eruption of minute, discrete papules, accompanied by marked itching. Etiology.—It is most commonly observed in the poor and ill-fed of Europe. It develops in early childhood and persists through life. Symptoms.—An eruption of small, discrete, deeply-situated, pale-red papules appears on the body, especially on the back and extensor surfaces of the extremities. The skin is harsh, dry, and thickened, and covered with numerous scratch-marks induced by the intense itching. Prognosis.—Unfavorable; it usually persists through life. Treatment.—The general health must be improved by good food and the use of nutrient tonics like iron and cod- liver oil. Frequent bathing, followed by ointments of tar, sulphur, or naphthol, gives relief. DERMATITIS HERPETIFORMIS. (Herpes Gestationis, Duhring's Disease.) Definition.—A chronic inflammatory disease, characterized by multiform lesions which form in groups, and which are associated with intense itching. Etiology.—Women are more commonly affected than men. Pregnancy, lactation, and menstrual disorders seem to exert a predisposing influence. Symptoms. Ei-ythematous Form.—This is characterized by the appearance in crops of erythematous patches which are associated with considerable itching. Papular Form.—Groups of papules appear in crops, and are frequently associated' with erythema vesicles and scratch- marks. Vesicular Form.—Groups of irregular-shaped vesicles resem- bling herpes appear in crops and are often associated with erythema, pustules, and scratch-marks. Pustular Form.—This resembles the former, but the vesicles are replaced by pustules. DERMATITIS. 451 Bullous Form.—Large irregular-shaped blebs appear in crops and tend to group. Vesicles and patches of erythema are also frequently present. Mixed Form.—Vesicles, erythematous patches, pustules, papules, and blebs appear in association, come out in crops, and are attended with intense itching. In the pustular, bullous, and mixed forms there may be marked constitutional disturbances. Prognosis.—Guardedly favorable. The disease runs a chronic course. Relapses are very common. Treatment.—Tonics are generally indicated. Lotions of boric or carbolic acid may be employed to allay itching, and may be followed by a dusting-powder. DERMATITIS. Definition.—Inflammation of the skin resulting from the action of some irritant. Dermatitis Traumatica.—This term is applied to inflam- mation of the skin resulting from traumatism. Treatment.—The removal of the cause and the applica- tion of soothing remedies will usually suffice. Dermatitis Venenata.—The term is applied to inflamma- tion of the skin resulting from the application of vegetable, animal, or chemical irritants. Notable examples of this form of dermatitis are observed in susceptible people after exposure to the influence of poison ivy (Rhus Toxicodendron), poison oak (Rhus Venenata), or poison sumach (Rhus Diversiloba). Symptoms of Rhus-poisomng.—The affection resembles acute eczema, and may appear in a few hours or not until the lapse of several days after exposure to the plant. It is generally observed on the face or hands. The part becomes red and swollen, and soon minute papules and vesicles appear. It gives rise to considerable burning and itching. As a rule, it subsides in a few days, but in patients with sensitive skin it may linger for several weeks. Treatment.—The part should first be bathed with castile soap and tepid water, and then treated with some sedative lotion or ointment. Black wash may be dabbed on, and zinc 452 DISEASES OF THE SKIN AND ITS APPENDAGES. ointment subsequently applied; or a saturated solution of boric acid may be followed by zinc ointment. When there is marked itching a weak solution of carbolic acid (3j to.Oj) is useful. The fluid extract of grindelia robusta has been highly recom- mended ; it may be applied in the strength of half an ounce to a pint of water. Dermatitis Calorica___This term is applied to the inflamma- tion of the skin resulting from extreme heat or cold. Pernio, or chilblain, is characterized by redness, swelling, intense burning and itching, and results from a sudden change from a low temperature to a high temperature. Frost-bite is char- acterized by congelation ; the part is of a dull-white color and is anesthetic; subsequently inflammation or gangrene develops. Burns and scalds result from the application of heat, and are divided into degrees according to the depth to which the destructive process extends. Treatment.—In pernio, or chilblain, the part should first be rubbed with snow or bathed in ice-water until the circula- tion is re-established ; and then an application made of nitrate of silver (gr. v to the ounce of distilled water) or of tincture of iodine. In superficial burns or scalds one of the following remedies may be applied : Phenol sodique, carron oil (equal parts of lin- seed oil and lime-water), powdered bicarbonate of sodium, or:— IJ Acidi carbolic, gr. viij ; Vaselin., gij.—M. (Beli/vue Hospital,.) Sig.—Spread on lint and apply where the skin is broken. Dermatitis Medicamentosa.—This term is applied to the various cutaneous eruptions which follow the internal use of certain drugs. Belladonna or Atropia.—These drugs produce a diffuse erythematous rash resembling that of scarlet fever, but it lacks the punctiform character of the latter. It usually ap- pears on the face, neck, and chest, and is associated with dry- ness of the throat, rapid pulse, and if the dose has been large, dilated pupils. Cubebs.—This drug sometimes produces an erythema asso- ciated with minute papules. ECTHYMA. 453 Copaiba.—The rash may be macular, papular, or like that of urticaria. Bromide of Potassium.—The eruption resembles acne and consists of papules and pustules. Iodide of Potassium.—The eruption may be erythematous, papular, pustular, urticarial, or purpuric. The most common eruption resembles acne, but the lesions are bright-red in color and widely distributed over the surface of the body. Arsenic.—The eruption may be erythematous, papular, vesicular, or pustular. Antipyrin.—This drug not infrequently produces a wide- spread papular eruption. Quinine.—The rash is usually erythematous, though an urticarial eruption has been observed. Salicyl Compounds.—The eruption is usually erythematous or urticarial. Borax.—This drug occasionally produces an eruption resem- bling psoriasis. Chloral.—The eruption is usually erythematous or urticarial. Dermatitis Exfoliativa. This is a rare affection, characterized by diffuse redness of the skin, high fever and its associated phenomena, and des- quamation. It is interesting from its close resemblance to scarlet fever, from which it may be distinguished by the history and the absence of sore throat, and a " strawberry" tongue. ECTHYMA. Definition.—An inflammatory affection, characterized by the appearance of discrete, flat pustules, which vary in size from a pea to a five-cent piece, and which are surrounded by a distinct red areola. Etiology.—Male sex, middle life, bad hygiene, and de- bility are predisposing factors. Symptoms.—Flat, yellow pustules appear in crops. They are surrounded by a distinct red areola and soon dry up, form- ing reddish-brown crusts. Slight excoriation and pigmenta- 454 DISEASES OF THE SKIN AND ITS APPENDAGES. tion sometimes remain after the separation of the crusts. Subjective phenomena are usually absent. Diagnosis.—The acute course, the absence of ulceration, and the absence of history and of associated symptoms of syphilis will separate it from the pustular syphilide. Impetigo.—In this affection the lesions are not flat; they are not distinctly inflammatory; and the crusts are light yellow, not reddish-brown. Impetigo occurs most frequently in child- ren, who may be quite robust. Prognosis.—Favorable. Treatment. — Constitutional treatment is generally re- quired. Such tonics as iron, quinine, strychnia, and cod-liver oil are often indicated. Local Treatment.—The crusts should be removed and some stimulating ointment applied, as the following :— IJ Hydrarg. ammoniat., gr. x ; Ung. zinci oxidi, §j.—M. PEMPHIGUS. Definition.—A non-contagious inflammatory disease, char- acterized by the eruption of successive crops of bulle or blebs. Etiology.—Female sex, nervous prostration, heredity, and injury to the peripheral nerves are predisposing factors. Varieties.—Pemphigus vulgaris and pemphigus foliaceus. Pemphigus Vulgaris.—This form usually runs a chronic course and is characterized by successive crops of blebs, vary- ing in size from a small pea to a large walnut. They are thoroughly distended with fluid, which is at first clear but subsequently turbid. As a rule, they do not rupture, but dis- appear in the course of five or six days, their contents being gradually absorbed. After absorption a thin pellicle remains, which dries and is subsequently detached, leaving behind a slightly pigmented spot, No part of the body is exempt; and as one set of blebs disappears, new ones rapidly develop, and so the disease continues for many years. In severe cases there may be considerable itching and burn- ing attending the eruption. IMPETIGO. 455 Pemphigus Foliaceus.—This rare and grave form of pem- phigus is characterized by crops of blebs, which are flaccid and filled with a turbid fluid almost from the beginning. They soon rupture and form thick crusts, which separating leave behind red weeping surfaces. The crops follow each other in rapid succession, and at times the whole body may be covered with blebs and scabs. The disease may last several years, death ultimately resulting from exhaustion. Diagnosis. Bullous Syphiloderm.—The history, the asso- ciated symptoms of syphilis, the thick, yellow, stratified crusts, and the underlying ulceration will serve to separate this affec- tion from pemphigus. Impetigo Contagiosa.—The acute course, the contagious and auto-inoculable character of the affection, and the umbili- cation of the blebs will separate impetigo contagiosa from pemphigus. Prognosis.—The prognosis should be guarded. Pemphi- gus vulgaris runs a long course and is often intractable. Pem- phigus foliaceus often proves fatal through exhaustion. Treatment.—The diet should be nutritious, but carefully adapted to the stomach. The patient should be placed under the best hygienic conditions. Tonics like iron, quinine, phos- phorus, cod-liver oil, and strychnia are usually indicated. In some cases arsenic may prove useful. Local Treatment.—The blebs may be punctured and subsequently dressed with zinc ointment. IMPETIGO. Definition.—An acute inflammatory disease, characterized by an eruption of discrete pustules varying in size from a pea to a cherry. Etiology.—The exciting cause is unknown. It is most commonly observed in children. Symptoms.—A pustular eruption appears generally on the « face and extremities. The pustules are generally few in num- ber, and are discrete, tense, and surrounded by a slight areola. In 'a few days they dry up and form thin yellowish-brown 456 DISEASES OF THE SKIN AND ITS APPENDAGES. crusts, which soon drop off and leave behind a normal surface. Subjective phenomena are absent. Diagnosis. Ecthyma.—This affection occurs most fre- quently in debilitated adults; the pustules are flat, sur- rounded by a distinct areola, and dry to brown crusts which separate and leave a pigmented excoriated surface. Impetigo Contagiosa.—As the name implies, this affection is contagious and is auto-inoculable; its pustules are flat and um- bilicated, and dry up and form lamellated, thin, yellow crusts. Prognosis.—Favorable. It terminates spontaneously in a few days or a week. Treatment.—Open the pustules and apply some simple protective ointment, like that of oxide of zinc. IMPETIGO CONTAGIOSA. Definition.—An acute contagious inflammatory disease, characterized by flat, yellowish blebs which dry up and form thin, yellow, lamellated crusts. Etiology.—Its exciting cause is unknown. It is most frequently observed in debilitated children. Symptoms.—The eruption is most frequently observed on the face and extremities ; it generally appears in crops, and is at first vesicular. The vesicles grow, and are soon converted into flat, umbilicated pustules which vary in size from a pea to a large walnut. They have a slight red areola. Itching is slight or entirely absent. In some cases there is moderate fever with its associated phenomena. In a few days the blebs dry up and form thin, yellow, lamellated crusts which separat- ing leave a slightly excoriated surface. The disease is con- tagious, and the lesions are auto-inoculable. Diagnosis. Eczema.—In this disease the pustules are similar, more confluent, excite intense itching, and are asso- ciated with inflammation and infiltration of the surrounding skin. Simple Impetigo.—This affection is not contagious or auto- inoculable; the pustules are tense, not flat or umbilicated; and the subsequent crusts are yellowish-brown and are not followed by excoriation. miliaria. 457 Prognosis.—Favorable. It terminates spontaneously in a few days or weeks. Treatment.—A slight stimulating ointment like the fol- lowing is sometimes useful:— IJ. Hydrarg. amnion., gr. v ; Adipis, £j.—M. Sig.—Apply to the surface after removal of the crusts. MILIARIA. (Prickly Heat.) Definition.—An acute inflammatory disease of the sweat- glands, characterized by a discrete eruption of minute papules and vesicles. Etiology.—Childhood and high temperature are the prin- cipal predisposing causes. Symptoms.—The eruption generally appears on the trunk, and consists of minute closely-aggregated red papules or clear vesicles. The lesions are discrete, and excite some burning and itching. It is generally associated with free perspiration. Diagnosis.—Eczema papulosum differs from miliaria in that the papules are larger, appear more gradually, disappear more slowly, and excite intense itching. Eczema vesiculosum differs from miliaria in that the vesicles are large, disappear more slowly, show a tendency to break, and are associated with marked itching. Sudamen differs from miliaria in that it lacks all inflamma- tory characteristics. Prognosis.—Favorable. Obstinate cases may persist for several weeks. Treatment.—The general health may require attention. The diet should be light, and easily assimilable. Constipation should be relieved by saline laxatives. Locally, a simple dusting-powder is generally all that is required. IJ. Pulv. amyli, gyj; Zinc, oxidi, ^iss; Pulv. camph., 3ss.—M. (Hardaway.) Sig.—Dusting-powder. 458 DISEASES OF THE SKIN AND ITS APPENDAGES. Or— IJ Zinc carbonat. precip., ^iv; Zinc, oxidi, gij ; Glycerini, f gij ; Aq. rose, fgviij. -M. (Tilbury Fox.) Sig.—Apply locally. ALBINISM. Definition.—A congenital deficiency of pigment. Etiology.—Beyond heredity, no cause is known. Partial albinism is more common in the negro. Symptoms.—In complete albinism the skin is white; the hair is thin, soft, and very light in color; the pupils appear red, the eyes are very sensitive to light, and the iris and choroid are deficient in pigment. VITILIGO. (Leucoderma.) Definition.—An acquired cutaneous affection, character- ized by milk-white patches which are surrounded by areas of increased pigmentation. Etiology.—The disease seems to be more common in the tropics and in the colored race. The condition probably results from disturbed innervation. Symptoms.—Milk-white spots appear on the body and grow very slowly; their borders usually reveal an increase of the normal pigment. Apart from the absence of pigment the skin is normal. Diagnosis. Morphoea.—The initial hyperemia and the subsequent atrophy of the skin will serve to distinguish morphea from vitiligo. Anaesthetic Leprosy.—The subjective symptoms, the atrophy of the tissues, and the anesthesia will separate leprosy from vitiligo. Prognosis.—Unfavorable; the disease usually persists through life. Treatment.—Tonics and local stimulants may be tried. Among the latter, electricity, blisters, and irritating ointments have been recommended. CANITIES--ATROPHY OF THE HAIR. 459 CANITIES. Definition.—Grayness of the hair. Etiology.—Local grayness may be congenital, or result from some disturbance of innervation, as in neuralgia of the supraorbital nerve. As a general condition it is usually an expression of senility, although it occasionally develops very early in life. Profound emotional disturbances sometimes induce an abrupt development of canities. Prognosis.—The condition is permanent, and treatment is of no avail. ATROPHIA CUTIS. Etiology.—Atrophy of the skin occurs under several con- ditions. A local atrophy may result from inflammation or injury of a nerve-trunk ; in these cases, the wrinkles are absent, the skin is thin, smooth, and shiny, and there is often intense burning in the part ("glossy skin"). Atrophy is also ob- served in leprosy, morphea, and scleroderma. Universal atrophy of the skin results from senility, and very rarely as an idiopathic condition. Sometimes the atrophy occurs in lines or spots (striae et maculae atrophica^) as an idiopathic condition, or as the result of stretching the skin, as in the lineae albicantes following pregnancy. ATROPHY OF THE HAIR. Etiology.—Atrophy of the hair may result from local diseases which interfere with the nutrition of the scalp, such as seborrhea, eczema, ringworm, etc.; or it very rarely arises as an idiopathic condition without obvious cause. Prognosis.—When the cause can be ascertained and re- moved, the prognosis is favorable. Treatment.—Local diseases will require appropriate treat- ment. The general health should be improved. Stimulating applications of mercury, sulphur, or carbolic acid are sometimes useful. 460 DISEASES OF THE SKIN AND ITS APPENDAGES. ATROPHY OF THE NAIL. Etiology.—Occasionally the condition is congenital, but more frequently it is acquired, and results from injury or dis- ease of the nerve-trunk; from some general disease, like one of the fevers, syphilis, or cancer; or from some disease of the skin, as psoriasis or ringworm. Symptoms.—The nails lose their lustre, cease to grow, and become opaque and brittle. Prognosis and Treatment.—Both will depend on the exciting cause. ALOPECIA. (Baldness.) Etiology.—(1) Baldness may be congenital; in these cases it is usually partial. (2) It may be an expression of senility; in which case it generally begins on the crown or brow, and is associated with more or less atrophy of the scalp. (3) It may occur early in life, as an idiopathic affection arising without obvious cause. (4) It may result from general diseases, like syphilis and the fevers. (5) In early life it is often due to some local disease, especially seborrhea. Prognosis.—In congenital, senile, and idiopathic alopecia the prognosis is unfavorable. In the alopecia of general dis- eases the prognosis is usually favorable. In alopecia result- ing from seborrhea much can be accomplished by persistent and judicious treatment. Treatment.—The general health should be improved. Frequent washing the head with warm water and castile soap is to be recommended. One of the following local stimulants may be prescribed : Cantharides, quinine, alcohol, capsicum, sulphur, or carbolic acid. IJ Quinine sulph., 3ss ; Tinct. cantharidis, fgj ; Spt. ammon. aromat., f^j ; 01. ricini, f^iss ; Spt. myrcie, f^vss; 01. rosmarini, gtt.v.— M. (Gerhard.) ALOPECIA AREATA. 461 IJ. Tinct. cantharidis, fjj ; Acid, carbolici, 3j ; 01. ricini, giss ; Spt. myrcie, Spt. lavandule, aa f Jij.—M. IJ. Tinct. cantharidis, LSij; Quinine sulph., gr. x ; Glycerini, f,§ss; 01. rostnarini, gtt.v; Spt. myrcie, q. s. adf^v.—M. ALOPECIA AREATA. (Alopecia Circumscripta.) Definition.—Baldness appearing in circumscribed patches without any obvious lesion of the skin. Etiology.—The cause is unknown. Some regard it as of parasitic origin, while others look upon it as a neurosis. It is generally observed in early adult life. Symptoms.—The disease is characterized by the sudden or gradual appearance of circumscribed round patches of bald- ness. At first there is no change in the appearance of the skin, but later it may become pale and atrophied. Although the scalp is the most frequent seat, it occasionally involves other hairy parts, as the eyebrows, beard, etc. Diagnosis. Ringworm.—Ringworm is exceedingly rare in adults, and is characterized by elevated scaly patches through which project dry, brittle, broken hairs. If there should be any doubt in the diagnosis, the microscope may be employed to detect the tricophyton. Prognosis.—In the majority of cases the hair returns under prolonged and persistent treatment. The older the patient the less favorable the prognosis. Treatment.—General tonics like iron, arsenic, quinine, and strychnia are usually indicated. The local treatment should be stimulating and consist in the application of blisters, elec- Or— Or— 462 DISEASES OF THE SKIN AND ITS APPENDAGES. tricity, friction, rubefacient liniments, or ointments containing chrysarobin, tar, sulphur, or ammoniated mercury. IJ Tinct. cantharidis, Tinct. capsici, aa f^iss ; Olei ricini, f^ij ; Alcoholis, f^vj ; Spts. rosmarini, f^ij.—M. (Duhring and Stelwagon.) Or— Or— IJ Acid, chrysophanic, 3iss ; Adipis, gij.— M. IJ Sulphur, loti, giv ; 01. cadini, 31J ; Adipis, gj.—M. SYCOSIS. (Simple Sycosis, Folliculitis Barbae.) Definition.—A non-contagious inflammatory disease of the hair-follicles. Etiology.—The affection probably results from local irri- tation. Symptoms.—The disease usually manifests itself on the bearded region of the face, and is characterized by an aggre- gation of papules and pustules, each of which is pierced by a hair. When the lesions are discrete the intervening skin is often quite healthy; but when they are close together it is often infiltrated and hyperemic. During the papular stage the hairs are not loose, but firmly attached; during the pus- tular stage, however, they can be readily extracted. The pustules show no tendency to rupture, but dry to yellowish- brown crusts. Acute cases are associated with more or less burning and itching. If the disease persists, it may lead to extreme destruction of the hair-follicles and, as a consequence, to permanent alopecia. Diagnosis. Eczema.—The lesions in eczema are not dis- crete, are not perforated by hairs, and are not confined to the hairy parts. Tinea Sycosis, or Barber's Itch.—The affection begins as a pompholyx. 463 red scaly patch, and is followed by the development of large, deeply-seated tubercles. The hairs soon become dry, brittle' and broken off, and can be easily extracted. In doubtful cases the microscope may be employed for the detection of the tricophyton. Prognosis.—The disease is curable under prolonged and judicious treatment. Relapses are very prone to occur. Treatment.—In acute cases soothing applications are in- dicated ; thus the parts may be dabbed with black wash or a saturated solution of boric acid, and subsequently spread with oxide of zinc ointment. In chronic cases the crusts should be removed, and the hairs cut close or preferably, shaved. It is advisable to puncture the pustules and to ex- tract the hairs, so as to preserve the follicles. When the parts are not irritable stimulating applications are useful, and one of the following may be selected :— IJ. Sulphur, precip., ^ij ; Ung. aque rose, gj.—M. Sig.—Apply twice daily. Or— IJ. Ung. diachyli, Ung. zinc, oxidi, aa ^iss ; Ung. hydrarg. amnion., giij ; Bismuth, subnitratis, £iss.—M. (Kobinson.) Sig.—Apply twice daily. Or— IJ Ichthyol., zj ; Ung. diachyli, gj; Sig.—Apply twice daily. POMPHOLYX. (Dysidrosis.) Pompholyx is a very rare disease, usually observed in those who perspire freely, and characterized by an eruption of deeply-seated vesicles which resemble sago-grains imbedded in the skin. The vesicles most commonly appear on the hands, especially between the fingers, and gradually increase in size 464 diseases of the skin and its appendages. until they reach the dimensions of blebs. They show no tendency to rupture, but dry up, and are followed by exten- sive desquamation of the cuticle. The eruption often excites considerable pain and tenderness. The disease usually dis- appears in the course of a few weeks, but is prone to recur. Treatment.—General tonics like iron, strychnia, and arsenic are often indicated. Locally, sedative lotions or oint- ments should be employed. LENTIGO. (Freckle.) Definition.—A deposition of pigment in the form of small, irregular-shaped brownish spots. Etiology.—Blondes are more subject to the affection than brunettes. Exposure to the sun's rays often serves as an exciting cause. Symptoms.—Exposed parts—the face, shoulders, arms, and hands—are mostly affected. The patches vary in color from yellow to dark brown, and range in size from a pin-head to a pea. Prognosis.—Freckles can be removed, but they always return. Treatment.—One of the best remedies is the bichloride of mercury in solution or ointment. IJ. Hydrarg. chlor. corros., gr. iv ; Alcohol, et aque, aa ad f|iv.—M. Sig.—Apply twice daily. CHLOASMA. Definition.—An abnormal deposition of pigment in the form of large brown or liver-colored patches. Etiology.—It may result from the application of external irritants; from general diseases like malaria and Addison's disease; or from affections of the uterus, as pregnancy tumors, etc. Symptoms.—The affection consists in the appearance__ especially on the face—of large, round, or irregular-shaped keratosis pilaris. 465 brownish or blackish patches. Apart from the discoloration the skin is normal. Diagnosis.—In Leucoderma the periphery of the patches is pigmented, but the central milk-white appearance is not seen in chloasma. Prognosis.—When the cause can be removed the prog- nosis is favorable. Treatment.—When possible the cause should be removed. The best local remedies are bichloride of mercury and sul- phur. IJ. Zinci oxidi, gr. iij ; Hydrarg. ammoniat., gr. iss ; 01. theobrom., 01. ricini, aa giiss ; Essent. rose, gtt. x.—M. (Monin.) Sig.—Apply to the face night and morning. KERATOSIS PILARIS. (Lichen Pilaris.) Definition.—Small, papular elevations resulting from hypertrophy of the epidermis surrounding the outlets of the hair-follicles. Etiology.—It generally results from infrequent bathing. Symptoms.—The skin, particularly on the extensor sur- faces of the arms and legs, is the seat of numerous pin-head elevations, which have a dirty-gray color and are pierced by hairs. It may excite some itching. Generally there are no evidences of inflammation, but sometimes a few red papules or even pustules result from irritation. Diagnosis.—In Cutis Anserina, or goose-flesh, the lesions are transient and have the color of normal skin. Prognosis.—Favorable. Treatment.—In most cases nothing will be required be- yond frequent bathing with soap, followed by friction of the skin. In obstinate cases some simple ointment may be ap- plied after bathing. 30 466 diseases of the skin and its appendages. MOLLUSCUM EPITHELIALE. (Molluscum Contagiosum, Molluscum Sebaceum.) Definition.—A cutaneous affection, characterized by the appearance of discrete wax-like elevations ranging in size from a pin-head to a pea, and varying in color from white to rose- pink. Etiology.—The disease is generally observed in children, and frequently affects several members of the same household, school, or asylum. It is probably contagious. Symptoms.—Small white or pale-pink, wax-like elevations appear, especially on the face. They are always discrete and rarely abundant. The centre of the elevation is depressed and reveals a dark spot which corresponds to the aperture of the follicle. At first the lesions are quite firm, but as they grow old they become soft. When firmly squeezed they exude a soft, cheesy material. After remaining for several weeks they break down or undergo slow absorption. Diagnosis.—The color, the wax-like appearance, the um- bilication, and the central aperture are the diagnostic features. Prognosis.—Favorable, although the disease may run a protracted course of months or years. Treatment.—General tonics like iron, strychnia, and arsenic are often indicated. The lesions should be incised, the contents expressed, and their bases touched with nitrate of silver; ointments of mercury and sulphur have also been rec- ommended. CALLOSITAS. (Callus, Keratoma, Tylosis.) Definition.—A thickened, horny condition of the skin resulting from hypertrophy of the corneous layer of the epi- dermis. Etiology.—Constant irritation from friction or pressure is the chief cause; hence it is frequently seen on the feet from the rubbing of shoes, and on the hands from the friction of tools. CLAVTJS. 467 Symptoms.—The condition is characterized by the gradual appearance of hard, thickened, grayish masses, which gradu- ally merge into healthy skin. The soles and palms are the parts most frequently affected. When slight it causes little inconvenience, but occasionally it becomes fissured and pain- ful. Prognosis.—It yields rapidly to treatment when the cause is removed. Treatment.—When excessive the parts should be soaked and the thickened epidermis pared off. One of the best reme- dies for softening the horny overgrowth is salicylic acid; it may be applied in the form of a plaster or in collodion. IJ Acid, salicylic, 3I; Collodii, flj.—M. Sig.—Apply night and morning. CLAVUS. (Com.) Definition.—Clavus is a circumscribed thickening of the epidermis usually appearing on the feet. Etiology.—Corns generally result from the friction of ill- fitting shoes. Symptoms.—Small, circumscribed, horny elevations appear upon the feet and often excite severe pain. When bathed in perspiration they become more or less macerated, and in this condition constitute the so-called soft corn. Treatment.—A radical cure requires the use of well- fitting shoes. The corns may be removed by soaking, paring, and the application of some mild caustic like salicylic acid. IJ. Acid, salicylic., gr. xxx ; Tinct. iodi, ttlx; Ext. cannabis ind., gr. x ; Collodii, fgss.—M. Sig.—Apply night and morning for several days, and then soak in hot water. 468 DISEASES OF THE SKIN AND ITS APPENDAGES. CORNU CUTANEUM. (Cutaneous Horn.) Definition.—A circumscribed, projecting outgrowth re- sulting from hypertrophy of the epidermis. Symptoms.—Horns generally appear on the face, scalp, or penis, and are usually observed in the old. They consist of dry, rough, horny, more or less conical projections, which vary in length from a few lines to several inches. Prognosis.—Favorable. Treatment.—The horn should be excised and the base subsequently cauterized. VERRUCA. (Wart.) Definition.—A wart is a circumscribed elevation result- ing from hypertrophy of the papille and epidermis. Etiology.—The cause is obscure. A bacterial origin has been suggested. They are most frequently observed in children. Symptoms.— Verruca Vulgaris, or common wart, is gener- ally observed on the hands of children. It consists of a firm, circumscribed elevation, varying in size from a millet-seed to a pea. Verruca plana, or flat wart, is a circumscribed, flat, pig- mented elevation usually observed on the backs of old people. Verruca Filiformis.—This is a thread-like overgrowth, and is generally observed on the soft parts, like the face and neck. Verruca Digitata.—This form is made up of numerous branches, and is generally observed on the scalp. Verucca Acuminata, or Venereal Wart.—This appears in groups about the genitalia. It is soft, red in color, and highly vascular. It may be dry or moist according to its location; the latter condition often gives rise to a peculiarly offensive odor. Treatment.—Ordinary warts may be removed by ex- cision, caustics, or electrolysis. ICHTHYOSIS. 469 Venereal warts should be bathed in some antiseptic solution and subsequently dusted with calomel, iodoform, or boric acid. N^VUS PIGMENTOSUS. (Mole.) Definition.—A circumscribed deposit of pigment, usually .associated with hypertrophy of cutaneous structures. Etiology.—Moles are usually congenital. ^ Symptoms.—The neck, face, and trunk are favorite locali- ties. The nevi vary in number from one to several hundred ; in size, from a millet-seed to a filbert; and in color, from yel- low to black. When the surface is smooth, the growth is termed naevus spilus ; when the surface is covered with hair, it is termed naevus pilosus; when the surface is warty, it is termed neevus verrucosus ; and when there is much overgrowth of connective tissue, it is termed naevus lipomatodes. Treatment.—They may be removed by excision, the ap- lication of caustics, or by electrolysis. ICHTHYOSIS. (Fish-skin Disease.) Definition.—A chronic affection characterized by dryness, thickening of the epidermis, and scaliness. Etiology.—The affection is often hereditary and is usually detected in early childhood. Symptoms. — The skin is dry and harsh ; the surface is covered with adherent polygonal scales; and the papille are more or less hypertrophied. The term Ichthyosis hystrix is applied to the condition when there is excessive hypertrophy of the papille. The extensor surfaces of the extremities are the parts most involved. Diagnosis.—The absence of all inflammatory symptoms will separate ichthyosis from squamous eczema and psoriasis. Prognosis.—The disease is incurable; but the patient can be rendered comfortable by appropriate treatment. 470 diseases of the skin and its appendages. Treatment.—The scales may be removed by alkaline baths or by applications of green soap. The skin may be rendered pliable by rubbing in some simple ointment. IJ Sulphuris, gr. xxv-1; Ung. simp., |j.— M. (Unna.) Sig. —Rub in at night. ONYCHAUXIS. Onychauxis, or hypertrophy of the nail, may be congenital, or may result from certain skin affections, such as eczema, ringworm, or syphilis; from diseases of the nerves, as neuritis; or from traumatism. HYPERTRICHOSIS. (Hirsuties.) Hypertrichosis, or hypertrophy of the hair, may be local or general. The term is applied not only to an excessive over- growth of hair, but to a growth of hair in unusual localities, as on the faces of young women. Treatment.—The hair may be removed temporarily by shaving, epilation, or depilatories. Permanent relief can only be accomplished by electrolysis. SCLERODERMA. (Sclerema, Scleriasis.) Definition.—A pigmented, rigid, indurated condition of the skin, occurring in circumscribed patches or involving the entire body. Etiology.—The cause is unknown. Symptoms.—The affection may be diffuse or involve cir- cumscribed patches. It may appear quite suddenly, or develop very gradually in the course of months or years. The skin assumes a yellowish-brown color, becomes rigid, indurated, and hide-bound ; the surface is unnaturally dry and smooth. When the condition is advanced the joints become more or less immobile. MORPHCEA—ELEPH ANTIASIS. 471 Prognosis. — Guarded. It often recovers spontaneously after having persisted for a long time. In other cases the pro- cess may spread until the patient becomes almost helpless. Treatment.—Tonics like iron, arsenic, and cod-liver oil are often indicated. Locally, massage, friction, electricity, and inunctions are recommended. MORPHGEA. (Addison's Keloid.) Definition.—A cutaneous affection, characterized by cir- cumscribed, rounded, ivory-like patches, which have hyperemic or pigmented borders. Etiology.—The cause is unknown. It is generally re- garded as a circumscribed form of leucoderma. Symptoms.—The lesions usually appear upon the trunk and consist of sharply-circumscribed patches, which are at first slightly hyperemic. The surface is smooth and resistant to the touch. As the patch grows old its centre becomes pale and ivory-like, while the periphery remains hyperemic or be- comes pigmented. Prognosis .—Gu arded. Treatment.—The same as scleroderma. ELEPHANTIASIS. (Elephantiasis Arabum, Elephantiasis Pachydermia, Barbadoes Leg.) Definition.—Hypertrophy of the skin and subcutaneous tissues, usually associated with lymphangitis, edema, and pig- mentation. Etiology.—While elephantiasis may occur in any part of the world, it is far more common in the tropics. It is most frequently observed in the male sex, and rarely develops before adult life. It results from obstruction of the lym- phatics, and the most common cause of such obstruction is the presence of a parasite—-filaria sanguinis hominis. 472 diseases of the skin and its appendages. Pathology.—Examination of the affected tissues reveals hypertrophy of the connective tissue, edema, and inflamma- tion and dilatation of the lymphatic vessels. Symptoms.—It usually begins with recurring attacks of erysipelatoid inflammation. The part is red, swollen, and painful; the lymphatics may be traced as branching red lines beneath the skin; and with these local phenomena there is more or less fever. After each attack the part is left a little enlarged, until finally it presents the following characteristic appearance: it is enormously swollen ; the skin is thickened, roughened, and pigmented ; and the papille are unusually prominent. The regions generally affected are the legs and genitals. In elephantiasis of the scrotum (lymph-scrotum) the hypertrophied mass may weigh as much as fifty or even a hundred pounds. Prognosis.—In the early stage the disease may be arrested, but when fully established it is incurable. Treatment.—The acute inflammatory attacks should be treated by rest and the application • of sedative lotions, like lead-water and laudanum. Subsequently mercurial inunc- tions may be employed, and the part firmly bandaged with the view of promoting absorption. Amputation may be suc- cessfully employed in lymph-scrotum. In elephantiasis of the limbs ligation of the main artery has given somewhat encouraging success. More recently galvanism has given very good results. DERMATOLYSIS. (Pachydermatocele, Cutis Pendula.) Definition.—A circumscribed hypertrophy of the skin and subcutaneous tissues resulting in a softened and pendulous condition of the integument. Symptoms.—The part affected is thickened and pigmented ; it is soft and fat-like to the touch ; and when the condition is marked, the skin hangs in folds. The regions generally affected are the shoulders, arms, back, and buttocks. Treatment.—The redundant tissue may be removed by excision or electrolysis. keloid—fibroma. 473 KELOID. (Cheloid, Kelis.) Definition.—A new growth resulting from hypertrophy of the connective tissue of the corium. Etiology.—It generally results from local injury, though it is claimed that it may arise spontaneously. Certain fami- lies and individuals are especially predisposed. It is more frequent in the colored race. Symptoms.—It begins as a pale-red nodule, which slowly increases in size and sends out claw-like processes. From its resemblance to a crab it has been termed keloid. It is firm, elastic, slightly elevated, sharply defined, and ranges in size from a small bean to a growth as large as the hand. It sometimes excites pain and itching, but generally subjective phenomena are absent. The regions most frequently involved are the chest and back. Diagnosis.—Keloid may be distinguished from a hyper- trophied scar by the fact that the latter does not extend beyond the limits of the injury. Prognosis.—The growth is usually permanent, and after removal invariably returns. Treatment.—It may be removed temporarily by excision, electrolysis, or caustic pastes. FIBROMA. (Molluscum Pibrosum.) Definition.—A circumscribed overgrowth derived from the subcutaneous connective tissue. Etiology—Early life and heredity are predisposing factors. Symptoms—The tumors are circumscribed; painless ; soft or firm ; often multiple ; range in size from a pea to a hen's egg; and do not impair the general health. The overlying skin may be normal in appearance or slightly hyperemic. Prognosis.—They are permanent and treatment is rarely indicated. 474 DISEASES OF THE SKIN AND ITS APPENDAGES. ANGIOMA. (Naevus Vasculosus.) Definition.—A new growth, composed of cavernous tissue, or a congeries of small bloodvessels. Angioma Cavernosum.—This form is congenital, is com- posed of cavernous tissue, and appears as a circumscribed, elevated, dark-red tumor, which ranges in size from a pea to one as large as the hand. It is often lobulated and pulsating. Angioma Simplex (Capillary Nevus,Port-wine lUark).—This form is also congenital, and is composed of a congeries of ca- pillaries. It is non-elevated, bright-red or purple-red in color, and may cover an area of several inches. It is gener- ally found on the face, and constitutes what is popularly termed a mother's mark. Telangiectasis.—This form is acquired, and is composed of dilated or newly-developed capillaries. It appears as a bright- red dot from which branch dilated capillaries. It is fre- quently associated with acne rosace; it is also common in those of a gouty diathesis and in those much exposed to the weather. Treatment.—Cavernous angiomata may be removed by ligation, excision, or electrolysis. Simple angiomata and telan- giectasis are best treated by electrolysis. XANTHOMA. (Vitiligoidea, Xanthelasma.) Definition. — A circumscribed connective-tissue new- growth appearing as flat patches or tubercles of a yellowish color. Etiology.—Middle life and female sex are general pre- disposing factors. Hepatic disorders, especially obstructive jaundice, seem to exert a decided predisposing influence. Symptoms.—There are two forms: Nanthoma planum, which generally appears about the eyelids and consists of smooth, circumscribed, slightly elevated, buff-colored patches; and Xanthoma tuberosum, which may appear em the neck, LUPUS ERYTHEMATOSUS. 475 shoulders, trunk, or extremities, and consists of small, elastic, and yellowish-colored nodules. Treatment.—These growths may be removed by excision, electrolysis, or caustics. LUPUS ERYTHEMATOSUS. (Seborrhoea Congestiva.) Definition—Lupus erythematosus is a new-growth result- ing from a cellular infiltration of the skin, and characterized by circumscribed, red patches which are more or less covered with yellowish-gray adherent scales. Etiology.—Middle life and female sex are predisposing factors. It frequently arises from disorders of the sebaceous glands, as seborrhea or acne. Pathology.—By many it is regarded as a chronic derma- titis which originates in the sebaceous glands. Symptoms.—The disease usually manifests itself on the face, in the region of the nose, and appears as small, red, slightly elevated papules, which are more or less scaly. An erythematous patch is gradually formed by the coalescence of these papules. The periphery of the patch is elevated and sharply defined, while the centre is depressed and atrophied. The ducts of the sebaceous glands are dilated and often filled with sebum. The disease spreads very slowly, shows no ten- dency to ulceration, and rarely excites any subjective symptoms. Diagnosis.—The location, the sharply-defined red patch with an elevated margin and depressed centre, the slight scali- ness, the dilated sebaceous ducts, the chronic course, and the absence of ulceration are the diagnostic features. Lupus Vulgaris.—This affection begins earlier in life, is characterized by tubercles and ulceration, and lacks involve- ment of the sebaceous glands. Prognosis.—Favorable under prolonged and judicious treatment. Treatment.—General tonics like iron, arsenic, phos- phorus, and cod-liver oil are often indicated. Local Treatment.—In many cases mild applications accomplish the most good. Much benefit is often derived 476 DISEASES OF THE SKIN AND ITS APPENDAGES. from washing the part thoroughly with green-soap and alcohol for a few days and then applying the following lotion :— IJ Zinc, sulphatis, Potassi sulphidi, aa 313; Aque, fjiij ; Alcoholis, fgj.—M. (Duhring.) Sig.—Shake well, dab the parts for fifteen minutes twice daily, and allow to dry on. In sluggish cases stimulating applications are useful, and one of the following may be selected:— IJ. Acid, salicyl., 3ss ; Acid, lactic, gss ; Resorcin., gr. xlv; Zinc, oxid., gij ; Vaselin. pur., ^xvij.—M. (Broca.) Or— I£ Acidi pyrogallici, gj ; Cerati, £ix.—M. (Kaposi.) Sig.—Apply locally. In obstinate cases, scarification, curetting, or burning with the galvano-cautery may be employed with advantage. LUPUS VULGARIS. (Lupus Exedens.) Definition.—A local manifestation of tuberculosis, char- acterized by soft red tubercles, which usually terminate in ul- ceration and scarring. Etiology.—Early life and female sex are general pre- disposing factors. It is comparatively rare in this country, but very common in Austria and Germany. The exciting cause is the tubercle bacillus. Symptoms.—Lupus vulgaris most frequently manifests it- self on the face, especially near the nose. It begins as minute, deeply-seated, reddish-brown papules, which grow very slowly until they reach the dimensions of tubercles. They are smooth, quite soft, and seldom painful. At this stage they may either undergo slow absorption or, which is more frequent, break down and leave chronic ulcers. The ulcers are shallow, and their LUPUS VULGARIS. 477 edges are soft and red. There is very little discharge. They spread slowly, and may involve all the soft parts, but the bone is never invaded. While one part of the ulcer is spreading, other parts are being filled with shrivelled cicatricial tissue which in turn is often the seat of new tuberculous nodules. Diagnosis. Epithelioma.—Epithelioma is a disease of ad- vanced life; it begins as a firm, wax-like nodule ; the resulting ulcer starts from a single point; its borders are distinctly ele- vated and hard; it secretes a blood-streaked fluid; and it is often painful. Syphilis—The age, history, associated evidences of syphilis, the rapid course, the deep ulcers, the abundant offensive dis- charge, and later the involvement of the bones, are the diag- nostic features. Prognosis.—Very guarded. Its removal is often followed by relapse. Treatment.—General tonics like iron, arsenic, phos- phorus, and cod-liver oil are usually indicated. Local Treatment.—The growth may be removed by cauter- ization, curetting, excision, or electrolysis. One of the fol- lowing caustic applications may be employed :— IJ. Acid, arsenosi, 9j ; Hydrarg. sulphuret. rub., gj; Ung. simplicis, gj.—M. (Hebra.) Sig.—Spread thick on cloth, and apply to the patch for two or three days, until lupus nodules and points are blackish or destroyed. Or— IJ Acid, lactic, puri, f^.— M. (Wichmann.) Sig.—Soak a pledget of absorbent cotton and apply to the ulcer. Cover with oil-silk and bandage. Protect normal tissue with grease. Or— IJ. Acid, salycilic, £ij ; Adipis benzoat., ^j.—M. Sig.—Apply locally. Often the best results are obtained by curetting and subse- quently applying caustics. Koch's tuberculin has lately been employed extensively in the treatment of lupus, but it has not given such good results as were expected. After its use most cases improve, many 478 DISEASES OF THE SKIN AND ITS APPENDAGES. relapse, a few recover. It seems best adapted to rapidly- spreading forms of lupus. SYPHILIS CUTANEA. The secondary symptoms appear between the first and fourth month following the chancre, and are characterized by a sym- metrical arrangement, a coppery color, polymorphism (many forms at the same time), and an absence of itching. They are usually associated with certain general symptoms, such as sore throat, pain in the bones, loss of hair, enlargement of the lymphatic glands, and failure of health. The tertiary symptoms appear in from six months to several years after the primary sore. They are as a rule localized, are tubercular, gummatous, or ulcerative in form, and tend to group. Macular Syphiloderm.—This is a secondary manifestation, and consists in a general eruption of dark-red macules, vary- ing in size from a millet-seed to a ten-cent piece. Diagnosis. Measles.—The absence of fever, of catarrh, of a crescentic arrangement, together with the history, will pre- vent an error in diagnosis. Papular Syphiloderm.—This may be an early or late mani- festation, and is characterized by a general eruption of large or small, dull-red papules. A few pustules are also frequently present. It pursues a chronic course, finally disappearing by desquamation, and leaving behind slight pigmentation. Diagnosis.—The history, distribution, dark color, and the presence of pustules will separate it from keratosis pilaris, papular eczema, and lichen ruber. ' Tuberculous Syphiloderm.—A late manifestation, charac- terized by a localized eruption of dark-red shiny papules varying in size from a pea to a large bean. By some these tubercles are regarded as gummatous in character. They pur- sue a chronic course and finally disappear by absorption or ulceration. The ulcers thus formed, when single, are round, punched out, and frequently covered with crusts; when they coalesce, they form a serpiginous sore which pours forth a thick yellowish discharge. SYPHILIS CUTANEA. 479 Diagnosis. Lupus Vulgaris.—This occurs in earlier life; it pursues an extremely chronic course; the ulcer is superficial; the tubercles are soft, and frequently redevelop in the scar tis- sue ; the secretion is scant; and the bone is never involved. Epithelioma.—In this affection the progress is slower ; there is only one point of ulceration; the secretion is scanty; and the border is markedly infiltrated. Bullous Syphiloderm.—This is a late manifestation, and is characterized by an eruption of well-filled blebs varying in size from a coffee-bean toa walnut. The contents of the blebs are puri- form. They subsequently form dark, conical, stratified crusts under which are ulcers pouring forth a thick, purulent fluid. Diagnosis. Pemphigus.—The history, the concomitant symptoms of syphilis, and thick, greenish crusts will serve to distinguish syphilis from pemphigus. Gummatous Syphiloderm.—This appears as a firm, circum- scribed nodule which gradually turns red and softens. It mav disappear by absorption, or break down and leave a deep punched-out ulcer. Moist Papules (Mucous Patches).—These consist in soft flat papules covered with an offensive, grayish secretion. Heat and moisture favor their development, so that their favorite seats are around the arms, the genitalia, the mouth, and in women under the mamme. Papulo-SquamoUS Syphiloderm.—This may be an early or late manifestation, and is characterized by a general erup- tion of small papules which are more or less scaly, so as to resemble psoriasis. Diagnosis.—The history, the slight scaling, the dirty-gray color of the scales, the dark-red color of the lesions, the espe- cial tendency to involve the palms and soles will serve to dis- tinguish syphilis from psoriasis. Squamous Eczema.—In this affection the distribution, the infiltration of the skin, and the marked itching will lead to a correct diagnosis. Annular Syphiloderm.—In this form the lesions consist of circles or semi-circles of small dark-red papules. Pustular Syphiloderm.—This form usually appears within the first year, and is characterized by a general eruption of small 480 DISEASES OF THE SKIN AND ITS APPENDAGES. or large, acuminated or flat pustules which finally dry up and form yellowish-brown crusts. Large lesions leave super- ficial ulcers. The term rupia is applied to large, conical, stratified crusts which rest loosely on the ulcerating basis. Diagnosis. Variola.—Absence of syphilitic history, the shot-like feel, the umbilication, the itching, the high fever, and the acute course will separate variola from syphilis. Acne.—This is usually limited to the face and shoulders; there is no history of syphilis or concomitant symptoms of that affection. Treatment.—The internal treatment consists in the ad- ministration of iodide of potassium, mercurials, and tonics. IJ Hydrarg. iodid., gr. j ; Potass, iodid., 3iv; Syr. sarsaparille co., Aque, aa f^ij.—M. (R. W. Taylor.) Sig.—Teaspoonful three times a day after meals. Or— IJ. Hydrarg. protiodidi, gr. v-x; Ext. opii, gr. v.—M. (Hardaway. Ft. in pil. No. xx. Sig.—One morning and evening. Local Treatment.—Papular eruptions may be washed with mercurial lotions; mucous patches may be dusted with calomel; ulcers may be dressed with iodoform. LEPROSY. (Lepra, Elephantiasis Graecorum.) Definition.—A chronic contagious disease, excited by the bacillus of leprosy, and characterized by tubercular formations, ulcerations, atrophy, disturbances of sensation, and an in- crease or decrease of pigment. Etiology.—The disease is contagious, but direct inocula- tion is essential to its transmission. It seems to be more common in hot climates. The exciting cause is the bacillus lepre, which closely resembles the tubercle bacillus. Varieties.—There are two varieties : Tubercular leprosy and anesthetic leprosy; but the two forms are often associated in the same patient. LEPROSY. 481 Symptoms.—Certain prodromes may precede the outbreak of the disease, such as malaise, headache, chilliness, depression of spirits, and numbness in the parts to be affected. Tuberculur Leprosy.—In this form spots of erythema ap- pear on the body; they soon become pigmented and hyper- esthetic, and develop into tubercles varying in size from a pea to a walnut. The face, extremities, and genitals are the parts most commonly affected, but occasionally the mucous mem- branes, especially of the nose and throat, are invaded. Ulti- mately the tubercles may break down and leave superficial indolent ulcers. In some cases a bullous eruption appears from time to time. The hair, eyebrows, and eyelashes fall out, the eyes become inflamed, the features distorted, and the voice husky. The disease may last many years, death finally result- ing from exhaustion or some intercurrent disease. Anaesthetic Leprosy.—In this form the peripheral nerves are invaded by the bacillus lepre. The outbreak may be preceded by numbness, itching, or lancinating pains. These symptoms are followed by the appearance of discolored spots, which are at first associated with hyperesthesia, but later more or less anesthesia develops. The skin and its appendages atrophy, the bones undergo necrosis, and the phalanges drop off one by one. In some cases (lepra alba) the skin is not only anesthetic, but distinctly white. Finally, when the nerves are more or less destroyed paralysis results. The duration is many years. Prognosis. —Unfavorable. A cure is practically impos- sible, though the progress of the disease may be stayed by appropriate treatment. Treatment. — Sufferers should be isolated. Tonics are usually indicated. Chaulmoogra oil and gurgun oil, inter- nally and externally, have been highly recommended. Exter- nally, chrysarobin, ichthyol, or resorcin may be applied to the affected parts. IJ. Chrysarobin, gr. x - 3J ; iEtheris et alcoholis ad q. s. Collodii, fgj.—M. (G. H. Fox.) Rub the chrysarobin with a little alcohol and ether, and add the collodion. Sig.—Paint the affected patch with a camel's-hair brush. 31 482 DISEASES of the skin and its appendages. EPITHELIOMA. (Skin Cancer.) Etiology.—Late life, heredity, and local irritation are the predisposing factors. Varieties.—Superficial, deep-seated, and papillomatous. Superficial Epithelioma (Rodent Ulcer).—This form usually begins as a firm, circumscribed, reddish-yellow, wax-like papule. After the lapse of several months or years the papule becomes scaly, and the removal of the scales is followed by a slight excoriation, which in turn becomes covered with a slight, reddish-brown crust. The latter tends to adhere, and its re- peated removal is followed by a raw surface, which is gradu- ally converted into an ulcer. The ulcer has a prominent in- durated margin; its outline is irregular; its base is uneven and glazed; and it exudes a sanious viscid excretion. It is not painful; it does not lead to enlargement of the neighboring lymphatic glands; nor does it cause impairment of the gen- eral health. It spreads very slowly, and sometimes becomes stationary or actually heals. More frequently the ulceration continues until it involves all the tissues of the part, even the bones. The ulcer generally appears on the face, and in its advance it may destroy the nose, eyes, or a large portion of the cranial bones. Deep-seated Epithelioma.—This variety may begin as a deep-seated, red, shiny tubercle, or it may develop from the superficial form. The ulcer which is ultimately formed is deep; its base is granular; its edges are everted, indurated, and of a reddish-purple color ; it secretes a blood-stained yellow fluid; it is the seat of lancinating pain ; it causes en- largement of the neighboring glands; and it sooner or later induces the cancerous cachexia. Death may result from ex- haustion, or more rarely, from hemorrhage caused by ulcer- ation of a large bloodvessel. Papillomatous Epithelioma,—This may begin as a warty excrescence, or may develop from one of the preceding varie- ties. It is characterized by an ulcerated surface from which springs an aggregation of large, highly-vascular papille. Be- AINHUM—DERMATALGIA. 483 tween the papille there are often deep-seated fissures from which exudes an offensive viscid discharge. The general health is impaired and the neighboring glands are enlarged. Diagnosis. Lupus Vulgaris.—Lupus begins in the young; the original papule is soft; there is often more than one centre of ulceration; the margins of the ulcer are not hard and everted ; the progress is extremely slow ; the discharge from the ulcer is very scant, and the bones are never involved. Syphilis.—The history, the associated evidences of syphilis, the rapid progress of the ulceration, the abundant discharge, the absence of pain, and the effect of treatment will suggest the diagnosis. Prognosis.—Guarded. A thorough removal in the begin- ning of the disease is often followed by a permanent cure. When the process is advanced the growth usually returns. Treatment.—Epitheliomatous growths may be removed by the use of caustics, the cautery, the curette, or by ex- cision. The last is preferable when the growth is small and circumscribed. AINHUM. Ainbum is a rare affection, occurring chiefly in the colored race, and characterized by the appearance of a groove or fur- row at the base of one or more of the toes. The groove deep- ens, the affected member becomes swollen, and finally drops off at the point of strangulation. DERMATALGIA. Dermatalgia, or neuralgia of the skin, is a rare affection, and is characterized by paroxysms of sharp, lancinating pain in the skin, which arise without any change in the local ap- pearance. It is most frequently observed in women of a neuropathic tendency, and may arise from any of the causes which induce neuralgia elsewhere. Treatment.—The cause must be sought for and, if pos- sible, removed. Tonics like iron, arsenic, quinine, and phos- phorus are often indicated. Locally, massage and electricity may prove useful. 484 DISEASES OF THE SKIN AND ITS APPENDAGES. PRURITUS. Definition.—Pruritus is a functional affection, character- ized by itching which is unassociated with any objective phe- nomena. Etiology—Pruritus may arise without obvious cause, as the Pruritus senilis observed in the old, and the pruritus hiemcdis which develops on the approach of cold weather and disappears when the weather becomes warm. Symptomatic Pruritus.—Pruritus may be a symptom of many conditions, notably diabetes, gout, lithemia, hysteria, neurasthenia, and Bright's disease. Symptoms.—There is only one symptom and that is itching ; but as a result of scratching, the part may become hyperemic, thickened, or the seat of eczema. Diagnosis.—Pruritus must be distinguished from the itch- ing induced by pediculosis, or some local disease, like eczema. Prognosis.—This will depend on the cause. When the primary disease is curable the prognosis for permanent relief is favorable. In other cases temporary relief only.is to be ex- pected. Treatment.—Search should be made for the exciting cause, which should be removed, if possible. In all cases the urine must be examined for sugar, since diabetes is one of the most frequent causes of pruritus. Among the internal reme- dies recommended for pruritus may be mentioned nux vomica, belladonna, and pilocarpin. The best local remedies are car- bolic acid, vinegar, thymol, chloral-camphor, boric acid, hydrocyanic acid, hot water, and menthol. IJ. Acid, hydrocyan. dil., f^ij ; Sodii borat., 3J ; Aq. rose, f ^viij.—M. (Fox.) Sig.—Use locally. IJ Menthol, 3iss; Alcoholis, fgiv.—M. Sig.—Use locally. IJ Acid, carbolic, fsj-fspj ; Aque et alcohol., aa q. s. ad Oj.—M. Sig.—Apply locally as often as necessary. TINEA tricophytina. 485 TLNEA TRICOPHYTINA. (Ringworm.) Definition.—A contagious disease excited by a vegetable parasite—the tricophyton. Varieties.—On the scalp it is termed Tinea tonsurans ; on the body, Tinea circineda; on the bearded region, Tinea sycosis. Tinea Tonsurans. This form is observed almost exclusively on the scalp of children. It is characterized by one or more rounded, scaly, elevated, grayish-colored patches through which project dry, brittle, lustreless, broken-off hairs. Diagnosis. Seborrhoea.— The patches are not circum- scribed ; the scales are greasy ; the hair is not involved ; and the microscope reveals no parasite. Eczema,—The patches are not circumscribed ; the hair is not involved; there is more inflammation; there is marked itching; and the microscope reveals no parasite. Alopecia Areata.—Baldness is complete ; there are no scales; and the base is smooth and shiny. Prognosis.—Favorable. Treatment. — Tonics are often indicated. The parts should be thoroughly washed with soap and water, and the affected hairs removed. The following parasiticides may be employed in ointment or lotion; mercury, sulphur, chrysarobin, or sulphurous acid. IJ. Acid, sulphurosi, f|j ; Aquae, f|iv.—M. Sig.—Apply several four or five times daily. Or— R Acidi salicylici, gr. xxx ; Sulphuris pracip., 3j; Yaselini, gj.—M. Sig.—Rub into affected area once or twice daily. (Hardaway.) 486 diseases of the skin and its appendages. Tinea Circinata. (Ringworm of the Body.) This appears as one or more rounded, red, slightly-elevated scaly patches, which on close examination reveal minute vesicles or papules. As the disease advances new patches spring from the periphery while the central portion clears up. There is often "considerable itching. Diagnosis. Psoriasis.—The marked scaling; the absence of itching; the tendency to involve the extensor surfaces, es- pecially the knees and elbows; and the absence of the tri- cophyton will separate psoriasis from ringworm. Eczema.—The patches are ill defined ; there is more itching; there is more infiltration of the skin ; and there is no trico- phyton. • Prognosis.—Favorable. Treatment.—Tonics are frequently indicated ; mercury, sulphur, sulphurous acid, and hyposulphite of sodium are among the best parasiticides. IJ Sodii hyposulphit.,3ij ; Aque, f^ij.—M. (Duhring.) Sig.—Apply locally. Or— IJ: Hydrarg. ammoniat., gr. xxx ; Adipis, 3j.— M. Sig.—Apply locally. Tinea Sycosis. (Barber's Itch, Sycosis Parasitica.) This begins as a red scaly patch involving the bearded region. Soon purplish tubercles and pustules form around the opening of the hair-follicles, and the hairs become lustre- less, brittle, and loose. There is often considerable itching. Diagnosis. Simple Sycosis.—Iii this the inflammation is superficial; the hairs are not involved ; and the tricophyton is absent. TINEA VERSICOLOR. 487 Eczema.—The tubercles, the involvement of the hairs, and the presence of the tricophyton will separate it from eczema. Prognosis.—Favorable ; unless treated actively, however, there may be a permanent loss of hair. Treatment.—The affected hairs should be removed, and one of the following parasiticides employed in lotion or oint- ment : Mercury, sulphur, or hyposulphite of sodium. IJ. Sodii hyposulphit., 3I1J ; Aque, fgiij.—M. Sig.—Apply locally. Or— I£ Sulphur, sublimat., 31J ; Vaselini, gij. Sig.—Apply locally. TINEA VERSICOLOR. (Pityriasis Versicolor.) Definition.—A chronic affection excited by a vegetable parasite, the microsporon furfur, and characterized by salmon- colored scaly patches which usually appear about the chest. Etiology.—rIt is a disease of adult life, and is more fre- quently observed in the debilitated and uncleanly. Symptoms.—It appears usually on the front of the chest as small round spots of a pale-yellow or fawn color, which slowly enlarge, fuse, and form slightly-elevated scaly patches. Sub- jective symptoms are generally absent. Diagnosis.—Chloasma somewhat resembles tinea versi- color ; but the former is not often observed on the trunk, is not scaly, and is not associated with a parasite. ' Prognosis.—Favorable. . Treatment.—The parts should be frequently washed with soap and water, after which one of the following parasiticides may be applied : Corrosive sublimate (gr. ij to an ounce of water), sulphurous acid, or hyposulphite of sodium :— IJ Sodii hyposulphitis, 3v ; Glycerini, f^iij ; Aque, q. s. ad fgv.—M. Sig.—Apply locally. 488 DISEASES OF THE SKIN AND ITS APPENDAGES. Or— IJ Hydrarg. chlor. corros., 9j ; Alcoholis, f|iv ; Saponis viridis, gij; 01. lavandule, f^j.—M. (Van Harlingen.) Sig.—To be rubbed in well night and morning. TINEA FAVOSA. (Favus.) Definition.—A contagious affection of the scalp excited by the achorion Schbnleinii, and characterized by yellowish, cup-shaped crusts. Etiology.—It is observed especially in poor, ill-nourished children. Symptoms.—The disease is characterized by one or more rounded, yellow, cup-shaped crusts, through which project dry, brittle, lustreless hairs. The underlying tissue is more or less atrophied and scarred. It is associated with some itch- ing and a peculiar musty odor. Diagnosis.—The yellow, cup-shaped crusts, the odor, and the atrophy of the skin will separate it from ringworm. Prognosis.—Favorable When not treated early it may be followed by permanent baldness. Treatment.—The crusts should be removed by oil, or soap and water. The affected hairs should also be removed. The following parasiticides are efficient: Mercury, sulphur, chrysarobin, and hyposulphite of sodium. SCABIES. (Itch.) Definition.—Scabies is a contagious disease excited by an animal parasite—the Acarus Scabiei—and manifested by pap- ules, vesicles, pustules, burrows, and intense itching. Etiology.-—The disease is always acquired through inti- mate intercourse with patients already affected. Svmptoms.—The disease manifests itself by intense itching, which is associated with an eruption of small papules, vesicles, pediculosis. 489 and pustules. Among these lesions may be found cuniculi, or burrow-s; these are discolored, dotted, slightly elevated lines ranging from a line to half an inch in length, and produced by the penetration of the female acarus and the deposition of her eggs along the passage. The parts most commonly affected are the hands between the fingers, the wrists, the axille, the genitalia, beneath the mamme, and the inner aspects of the thighs. The face and scalp are never involved. Diagnosis.—The recognition of scabies rests on the history, the itching, the presence of burrows, the multiformity of the lesions, and their peculiar distribution. Prognosis.—Favorable. Treatment.—The following remedies are efficient: Sul- phur, styrax, and naphthol. IJ. Sulphur, sublimat., 3] ; Balsam. Peruvian., sjss ;v Adipis, 5j.—M. (Duhring.) Sig.—Rub in thoroughly twice daily. Or- IJ Naphthol., gr. lxxx ; Saponis viridis, §ss; Crete alb. pulv., gr. 1; Adipis, 3j.—AT. (Kaposi.) Or— IJ. Storacis, f§j ; Spt. vin. rect., fgij.—M. Et adde— 01. olive, f^j. (McOai/l Anderson.) Sig.—Rub the parts thoroughly ; repeat in twenty-four hours. PEDICULOSIS. (Phtheiriasis.) Pediculosis Capitis.—This form results from the pediculus capitis, or head-louse, a gray insect from one to two milli- metres in length. The condition is recognized by itching of the scalp and the discovery of the lice or their white ova, or nits. Eczematous lesions resulting from scratching are often observed. 490 DISEASES OF THE SKIN AND ITS APPENDAGES. Pediculosis Corporis.—This form results from the pediculus corporis, pediculus vestimenti, or body-louse, a somewhat larger insect than the head-louse. The condition is recog- nized by intense itching on the covered parts of the body, scratch-marks, petechie caused by the bite of the insect, and the discovery of the lice on the garments. Pediculosis Pubis.—This form results from the pediculus pubis, or crab-louse, a minute, gray, translucent insect. It is found on parts covered with short hair, as the pubes, axille, eyebrows, etc. Treatment.—In pediculosis capitis the head may be thor- oughly washed with coal-oil, dilute carbolic acid (3j to Oj), or tincture of cocculus indicus. In pediculosis corporis the parts should be thoroughly washed and the clothes subjected to a high temperature. The body may be bathed in a weak solution of corrosive sublimate. In pediculosis pubis an ointment of mercury is very efficient. INDEX. ABDOMEN, distention of, 23 Abscess, cerebral, 350 hepatic, 80 perinephritic, 106 retropharyngeal, 30 Acetone, test for, 93 Acetonuria, causes of, 93 Acholia, 73 Acidity, gastric, 20 degree of, 21 test for, 21 Acids, fatty, in sputum, 159 Acne, 440 Acromegalia, 405 Addison's disease, 115 iEgophony, 167, Agraphia, 388 Ague, 250 Ainhum, 483 Alae nasi, movement of, 153 Albinism, 458 Albumin, tests for, 92 Alopecia, 460 areata, 461 Amoeba coli, 52 Anaemia, 111 cerebral, 340 essential, 112 idiopathic, 112 lymphatic, 115 pernicious, 112 primary, 112, 113 symptomatic, 111 varieties of, 111 Anaesthesia, causes of, 320 Analgesia, causes of, 321 Anchylostomum duodenale, 64 Aneurism, aortic, 148 Angina pectoris, 147 Angioma, cutaneous, 474 Anidrosis, 430 Animal parasites, 62 Ankle-clonus, 319 Anorexia, 19 Anosmia, 154 Anuria, 85 Aortic aneurism, 148 Aortic valves, diseases of, 135, 136 Apex-beat, 119 changes in the force of, 120 displacement of, 120 Aphasia, 387 Aphemia, 387 Aphonia, causes of, 154 Apoplexy, cerebral, 341 pancreatic, 69 pulmonary, 199 Appendicitis, 58 Appetite, disturbances of, 19 Argyll-Robertson pupil, 328 Argyria, 415 Arteries, obstruction of cerebral, 345 Arthritis deformans, 300 rheumatoid, 300 Arthropathies, 324 Ascaris lumbricoides, 63 Ascites, 67 Asthma, 191 Ataxia, locomotor, 357 Athetosis, 316 Atrophy, facial, 405 idiopathic muscular, 369 myopathic, 369 muscular, causes of, 323 of liver, acute yellow, 84 progressive muscular, 365 Auscultation, immediate, 166 mediate, 166 of chest, 165 of heart, 123 (491> 492 INDEX. BACILLUS, tubercle, 159 detection of, 160 Bell's palsy, 383 Beriberi, 381 Bile-ducts, catarrh of, 73 Bile in the urine, 94 tests for, 94 Blebs, causes of, 422 Blood, diseases of, J.09 Bothriocephalus latus, 62 Bonlimia, 19 Brachycardia, 126 Brain, abscess of, 350 anaemia of, 340 congestion of, 339 tumors of, 347 Breath, fetor of, 18 Breathing, amphoric, 166 asthmatic, 167 bronchial, 166 cavernous, 166 Cheyne-Stokes, 156 cogged-wheel, 167 exaggerated, 166 in emphysema, 167 jerky, 167 normal, 166 puerile, 166 tidal-wave, 156 weak, 167 Bright's disease, acute, 97 chronic, 99, 100 Bromidrosis, 431 Bronchial tubes, dilatation of, 189 Bronchiectasis, 189 Bronchitis, 182 acute catarrhal, 182 capillary, 187 chronic, 184 fibrinous, 188 Bronchophony,167 Bronchorrhagia, 198 Bruit, aneurismal, 125 Bullae, causes of, 422 CACHEXIA, malarial, 254 Calculus, renal, 103 Calculi, biliary, 74 Callositas, 466 Cancer, gastric, 42 Cancer— hepatic, 81 pancreatic, 69 Cancrum oris, 25 Canities, 459 Caput Medusae, 416 Carbunculus, 444 Cardiac dulness, diminished area of, 123 increased area of, 123 Catalepsy, 327 Catarrh, autumnal, 194 biliary, 73 bronchial, 182, 184 gastric, acute, 33 chronic, 37 intestinal, 48 nasal, 171 pharyngeal, 30 suffocative, 187 Causalgia, 322 Cephalalgia, 375 Cerebro-spinal fever, 247 Charcot-Leyden crystals in sputum, 159 Chest, auscultation of, 164 dulness of, on percussion, 165 emphysematous, 161 expansion of, 163 funnel, 162 inspection of, 161 mensuration of, 169 palpation of, 161 percussion of, 164 phthisinoid, 161 rachitic, 161 Chest-walls, oedema of. 163 Cheyne-Stokes respiration, 156 Chicken-pox, 266 Chloasma, 464 Chlorides in the urine, 89 Chlorosis, 113 Cholaemia, 73 Cholelithiasis, 74 Cholesteraemia, 73 Cholera, Asiatic, 283 infantum, 56 morbus, 55 Cholerine, 284 Chorea, Huntingdon's, 316 minor, 396 INDEX. 493 Chorea— insaniens, 397 Choreiform movements, causes of, 315 Cirrhosis, hepatic, 77 pancreatic, 69 Clavus, 467 Cold in the head, 170 Cold, rose, 194 Colic, biliary, 75 definition of, 21 intestinal, 47 mucous, 49 renal, 104 Coma, causes of, 325 Comedo, 433 Compensation in cardiac disease, 135 Conception, imperative, 329 Congestion, cerebral, 339 hepatic, 76 pulmonary, 200 renal, 95 Consciousness, disturbances of, 325 Consumption, pulmonary, 216 Contraction, paradoxical, 320 Convulsions, 313 epileptiform, 313 hysteroidal, 314 local, 315 salaam, 315 tetanic, 314 varieties of, 313 Cornu cutaneum, 468 Corpuscles, red, diminution of, 109 white, increase of, 109 Coryza, 170 Cough, causes of, 156 dry, 156 laryngeal, 157 moist, 157 winter, 184 Cow-pox, 267 Cramp, artisans', 400 writers', 400 Cretinism, 351 Crisis, definition of, 231 diseases terminating by, 235 Croup, false, 176 membranous, 177 pseudo-membranous, 177 spasmodic, 176 Croup— true, 177 Crusts, cutaneous, causes of, 426 Cyanosis, causes of, 129 congenital, 129 DECUBITUS, 325 Defecation, painful, causes of, 22 Degeneration, reactions of, 323 Delusion, varieties of, 329 Delirium, definition of, 329 causes of, 329 tremens, 408 Dermatalgia, 483 Dermatitis, 451 exfoliativa, 453 herpetiformis, 450 Dermatolysis, 472 Dengue, 288 Diabetes insipidus, 308 mellitus, 304 Diacetic acid, tests for, 93 Diaceturia, causes of, 93 Diarrhoea, 47 varieties of, 48 Diathesis, uric-acid, 303 Diphtheria, 274 Dipsomania, 408 Disease, Addison's, 115 Basedow's, 402 bleeder's, 116 caisson, 368 Duchenne's, 357 Friedreich's, 362 Graves's, 402 Hodgkin's, 115 Landry's, 367 Marie's, 405 Meniere's, 390 Parkinson's, 398 Raynaud's, 403 Thomsen's, 401 Diuresis (see Polyuria), 85 Dizziness, 389 Dropsy, causes of, 129 Dysentery, 52 amoebic, 52, 53 catarrhal, 52 chronic, 53 diphtheritic, 52, 53 494 INDEX. Dysentery— malignant, 52, 53 Dyspepsia, 34 atonic, 35 catarrhal, 37 nervous, 35 ECHINOCOCCUS of the liver, 83 Ecstasy, 327 Ecthyma, 453 Eczema, 446 Effusion, abdominal (see Ascites), 67 pericardial, 131 pleural, 224 Elephantiasis, 471 Embolism, cerebral, 345 Emphysema, cutaneous, causes of, 416 pulmonary, 195 varieties of, 195 Empyema (see Purulent Pleurisy), 225 Endocarditis, 133 acute, 134 chronic, 135 malignant, 141 sclerotic, 133 ulcerative, 141 vegetative, 133 Enteritis, acute, 48 catarrhal, 48 chronic, 48 membranous, 49 Entero-colitis, 51 Entrorrhagia, causes of, 22 Epilepsy, 385 Epistaxis, causes of. 154 Epithelioma, cutaneous, 482 Erysipelas, 268 Erythema, 436 Eruptions, time of appearance of, 233 Exhaustion, heat, 407 Expectoration, varieties of, 157 Eyeball, tremor of, 328 Eyes, conjugate deviation of, 328 MCE, atrophy of, 405 palsy of, 383 spasm of, 372 Fastigium, definition of, 231 Favus, 488 Febricula, 236 Fecal discharges, 22 Festination, 317 Fever, 230 break-bone, 288 catarrhal, 280 causes of, 232 cerebro-spinal, 247 degrees of, 231 detection of, 230 effects of, on tissue, 232 ephemeral, 236 enteric, 237 famine, 245 hay, 194 intermittent, 250 jungle, 252 lung, 202 malarial, 250 pulse-temperature, ratio in, 232 relapsing, 245 remittent, 252 rheumatic, 290 scarlet, 256 simple continued, 236 spirillum, 245 spotted, 247 stages of, 230 symptoms of, 232 terminations of, 231 thermic, 406 treatment of, 232 types of, 331 typhoid, 237 typhus, 243 yellow, 270 Fevers, continued, 231 intermittent, 231 remittent, 231 Fibre, elastic, in sputum, 158 Fibromata, cutaneous, 473 Filaria sanguinous hominis, 64 Floating kidney, 107 Fremitus, tactile, 163 vocal, 163 Friction-sound, pericardial, 12E pleural, 224 Furunculus, 443 INDEX. 495 GAIT, ataxic, 317 spastic, 317 steppage, 317 Gall-ducts, inflammation of, 73 Gall-stones, 74 Gangrene, symmetrical, 325, 403 Gastralgia, 39 Gastric cancer, 42 ulcer, 40 catarrh, 33, 37 Gastritis, acute, 33 chronic, 37 Gastrodynia, 39 Glottis, oedema of, 181 spasm of, 179 Glucose, tests for, 90 Glycosuria, causes of, 90 Goitre, exophthalmic, 402 Gout, 297 latent, 303 rheumatic, 300 Graphospasm, 400 Green sickness, 113 HAEMATEMESIS, causes of, 45 Haematoidin in the sputum, 159 Haematoma of the dura mater, 334 Haematuria, causes of, 93 Haemoglobin, diminution of, 110 Haemoglobinuria, causes of, 94 Haemopericardium, 133 Haemophilia, 116 Haemoptysis, causes of, 198 Hair, atrophy of, 459 hypertrophy of, 470 trophic affections of, 325 Hallucination, 329 Hay-fever, 194 Headache, 375 Heart, auscultation of, 123 dilatation of, 143 fatty degeneration of, 145, 146 infiltration of, 145 fibroid, 142 hypertrophy of, 143 inspection of, 119 neuralgia of, 147 palpation of, 122 percussion of, 122 Heart-sounds, accentuation of, 123 Heart-sounds— reduplication of, 124 weakness of, 124 Hemianaesthesia, causes of, 320 Hemi-atrophy, facial, 405 Hemicrania, 374 Hemiplegia, causes of, 311 Hemorrhage, cerebral, 341 broncho-pulmonary, 198 from the intestines, 22 from the kidneys, 93, 94 from the lungs, 198 from the nose, 154 from the stomach, 45 Hepatitis, acute, 80 catarrhal, 73 interstitial, chronic, 77 Herpes iris, 440 simplex, 438 zoster, 439 Hiccough, causes of, 21 Hives, 437 Hodgkin's disease, 115 Hydatids of the liver, 83 Hydrocephalus, 334 acute, 331 Hydronephrosis, 106 Hydrophobia, 288 Hypereemia, cerebral, 339 hepatic, 76 pulmonary, 200 renal, 95 Hyperaesthesia, causes of, 322 Hyperidrosis, 430 Hypertrichosis, 470 Hypertrophy, cardiac, 143 pseudo-muscular, 370 Hysteria, 391 [CHTHYOSIS, 469 I Icterus, 71 Icterus neonatorum, 72 Ileus, varieties of, 59 Illusion, 329 Impetigo, 455 contagiosa, 456 Impulse, morbid, 329 Incubation, periods of, 233 Indican, test for, 94 Indicauuria, causes of, 94 496 INDEX. Influenza, 280 Insane, general paralysis of, 336 Inspection of the chest, 161 of the praecordia, 119 Intestinal obstruction, 59 Intussusception, 60 Invagination, 60 Itch, 488 barbers', 486 JAUNDICE, catarrhal, 73 causes of, 71, 72 haematogenous, 72 hepatogenous, 71 malignant, 84 non-obstructive, 72 obstructive, 71 varieties of, 71 KIDNEY, amyloid degeneration 102 congestion of, 95 diseases of, 85 floating, 107 gouty, 100 inflammation of, acute, 97 chronic, 99, 100 large white, 99 movable, 107 red granular, 100 stone in, 103 waxy, 102 Keloid, 473 Keratosis pilaris, 465 Knee-jerk, 318 causes which diminish, 318 which increase, 318 T A GRIPPEE, 280 Ij Landry's disease, 367 Laryngismus stridulus, 179 Laryngitis, 173 Larynx, oedema of, 181 Lead-poisoning, chronic, 411 Lentigo, 464 Lepra, 480 Leptomeningitis, cerebral, 333 spinal, 352 Leucin in the urine, 87 Leucocythaemia, 114 Leucocytosis, 109 Leucoderma, 458 Lichen planus, 449 ruber, 449 scrofulosis, 449 Lipaemia, 111 Lithaemia, 303 Lithuria, 86 Liver, abscess of, 80 acute yellow atrophy of, 84 amyloid, 82 cancer of, 81 cirrhosis of, 77 consistence of, 70 diminution in the size of, 71 echinococcus of, 83 enlargement of, irregular, 71 uniform, 71 hydatids of, 83 hypereemia of, 76 inflammation of, 73, 77, 80 palpation of, 70 percussion, 71 pulsation of, 71 Localization, cerebral, 348 Lockjaw, 286 Locomotor ataxia, 357 Lumbago, 295 Lungs, abscess of, 213 cirrhosis of, 211 collapse of, 215 congestion of, 200, 201 gangrene of, 212 infarction of, 199 oedema of, 215 Lupus erythematosa, 475 vulgaris, 476 MACROCYTOSIS, 110 Macules, causes of, 417 Malaria, haematozoa of, 251 malignant, 253 Malarial cachexia, 250 fever, 254 Mania a potu, 408 Measles, 260 German, 262 Melaena (see Entrorrha/jia), 22 INDEX. 497 Melanaemia, 110 Meniere's disease, 390 Meningitis, cerebral, 331, 333, 334 epidemic cerebro-spinal, 247 spinal, 352 tuberculous, 331 Meningo-encephalitis, chronic, 336 Mensuration of the chest, 169 Microcytosis, 110 Migraine, 374 Miliaria, 457 Milium, 434 Mitral diseases, 136, 137 Molluscum epitheliale, 466 Monanaesthesia, causes of, 321 Monoplegia, causes of, 311 Morbilli, 260 Morbus maculosus Werlhofii, 117 Morvan's disease, reference to, 363 Mouth, diseases of, 23 Mucin, spiral of, in sputum, 158 Multiple neuritis, 381 Mumps, 281 Murmur, respiratory, modifications of, 166 Murmurs, aneurismal, 125 cardiac, 124 haemic, 124 Muscular contraction, paradoxical, 320 Myalgia, 295 Mydriasis, causes of, 327 Myelitis, 354 Myocarditis, 142 Myosis, causes of, 327 Myotonia, congenital, 401 Myxcedema, 324, 404 NJEVUS pigmentosa, 469 Nails, atrophy of, 417, 480 curving of, 417 Nasal catarrh, 171 Nematodes, 63 Nephritis, acute, 97 catarrhal, 97 parenchymatous, 97 chronic catarrhal, 99 interstitial, 100 Nephrolithiasis, 103 Neuralgia, 371 32 Neurasthenia, 395 Neuritis, 379 multiple, 381 Nose, red, causes of, 153 Nutrition, disturbances of, 322 Nystagmus, 328 OBSTRUCTION, intestinal, 59 CEdema, causes of, 416 acute, angio-neurotic, 404 of the larynx, 181 of the lungs, 214 Oesophageal obstruction, varieties of, 31 GSsophagismus, 32 Oligocythaemia, 109 Onychauxis, 470 Onychia, 417 Opium-poisoning, 410 Oxalates in the urine, 89 Oxybutyria, causes of, 93 Oxybutyric acid, test for, 93 Oxyuris vermicularis, 64 Ozaena, 172 PACHYMENINGITIS, cerebral, 333 hemorrhagic, 334 spinal, 353 Palpation of the chest, 163 of the heart, 122 Palpitation, 128 Palsy, 310 Bell's, 383 bulbar, 367 hysterical, 391 shaking, 398 Pancreas, diseases of, 69 Papules, cutaneous, causes, 424 Paraesthesia, 322 Paralysis, acute ascending, 367 agitans, 398 atrophic spinal, 363 causes of, 310 cerebral, in children, 338 divers', 368 glosso-labio-laryngeal, 367 infantile, 363 laryngeal, 155 pseudo-hypertrophic, 370 498 INDEX. Paramyoclonus multiplex, 316 Paraplegia, ataxic, 361 causes of, 312 primary spastic, 360 Parasites, intestinal, 62 Paretic dementia, 336 Parosmia, 154 Parotitis (see Mumps), 281 Pectoriloquy, 167 Poliosis Rheumatica, 419 Pemphigus, 454 Percussion immediate, 164 mediate, 164 of the heart, 122 of the lungs, 164 Pericarditis, 130 Pericardium, adherent, 131 air in, 133 blood in, 133 dropsy of, 132 Peritonitis, 65 Perityphlitis, 58 Pernicious anaemia, 112 Pertussis, 278 Petechiae, causes of, 418 Pharyngitis, 29 Phosphates in the urine, 88 Phthisis, 216 acute, 217, 219 fibroid, 219 chronic ulcerative, 217 Pica, 19 Pleurisy, acute, 223 diaphragmatic, 225 fibrinous, 225 hemorrhagic, 224 purulent, 225 tuberculous, 225 Pleurodynia, 295 Plumbism, 411 Pneumonia, alcoholic, 202 broncho-, 207 catarrhal, 207 chronic interstitial, 211 croupous, 202 hypostatic, 201 in children, 204 lobar, 202 senile, 204 typhoid, 204 Pneumopericardium, 133 Pneumothorax, 227 hydro-, 227 pyo-, 227 Poikilocytosis, 109 Poisoning, arsenical, chronic, 413 lead, chronic, 411 mercurial, chronic, 412 opium, 410 Poliomyelitis, acute anterior, 363 chronic, 365 Polyuria, causes of, 85 Pompholyx, 463 Progressive muscular atrophy, 365 Prurigo, 450 Pruritus, 484 Pseudo-leukaemia, 115 Pseudo-muscular hypertrophy, 370 Psoriasis, 444 Ptyalism, 25 Pulmonary valve, affections of, 138 Pulsation, abnormal centres of, 121 Pulse, bigeminal, 126 Corrigan's, 128 dicrotic, 127 high-tension, 127 increased frequency of, 125 intermittent, 126 irregular, 126 jugular, 128 low-tension, 128 trigeminal, 126 venous, 128 water-hammer, 128 Pulses, asymmetrical radial, 128 Pulsus paradoxus, 127 Purpura hemorrhagica, 117 Purpuric rashes, causes of, 418 Pus in the expectoration, 157 in the stools, 22 in the urine, 95 in the vomit, 20 Pustules, causes of, 422 Pyelitis, 105 Pyelonephritis, 105 Pylorus, obstruction of, 43 Pyonephrosis, 105 Pyrexia, 230 Pyuria, causes of, 95 AUINSY, 26 INDEX. 499 RABIES, 288 Rachitis, 302 Rales, 168 Rashes, time of appearance of, 233 Raynaud's disease, 403 Reflexes, deep, theory of, 318 causes which diminish, 311 which increase, 318 superficial, 319 Relapsing fever, 245 Remittent fever, 252 Renal calculus 104 colic, 104 congestion, 95 Resonance, pulmonary, diminished, 165 increased, 164 outlines of, 164 vocal, diminution of, 167 increase of, 167 Respiration, normal, 166 disturbances of, 156, 166 Respiratory murmur, modifications of, 166 Retro-pharyngeal abscess, 30 Rheumatism, acute articular, 290 chronic, 294 inflammatory, 290 muscular, 295 Rheumatoid arthritis, 300 Rhinitis, 170 Rickets, 302 Ringworm, 485 Romberg's symptom, 358 Rose cold, 194 Roseola, epidemic, 262 Rotheln, 262 Rubella, 262 Rubeola, 260 SALAAM convulsions, 315 Salivation (see Mercurial Stoma- titis), 25 Sarcinae ventriculi, 44 Scabies, 488 Scales, cutaneous, diseases which cause, 427 Scarlatina, 256 Scarlet fever, 256 Sciatica, 382 Scleroderma, 470 Sclerosis, spinal, 357 amyotrophic lateral, 360 disseminated, 361 lateral, 360 multiple, 361 posterior, 357 Scorbutus, 117 Scurvy, 117 Seborrhoea, 432 Sensation, disturbances of, 320 Sense, muscular, 322 Senses, special, disturbances of, 327 Sensibility, muscular, 322 Skin, discolorations of, 414 glossy, 416 hardness of, 414 pallor of, 414 Smallpox, 263 Smell, sense of, disturbances of, 154 Softening, cerebral, 346 Somnambulism, 327 Sound, cracked-pot, 165 Sounds, adventitious pulmonary, 168 Spasm, laryngeal, 154 oesophageal, 32 saltatory, 315 Spinal cord, sclerosis of, 357 Sputum, Charcot-Leyden crystals in, 159 currant-jelly, 157 elastic fibre in, 158 fatty acids in, 159 fetid, 157 fibrinous shreds in, 157 haematoidin in, 159 microscopy of, 158 mucin in, 158 muco-purulent, 157 prune-juice. 157 purulent, 158 rusty, 157 spirals, Curschmann's, in, 192 tubercle bacilli in, 160 Stenocardia, 147 Stomach, cancer of, 42 dilatation of, 43 .inflammation of, 33, 37 neuralgia of, 39 ulcer of, 40 Stomatitis, 24 500 INDEX. Stools, changes in, in disease, 22 Steatoma, 435 Stricture, intestinal, 61 oesophageal, 31 pyloric, 43 St. Vitus's dance, 396 Succussion-splash, 169 Sudamen, 431 Sugar in the urine, 90 tests for, 90, 91 Sunstroke, 406 Swallowing, difficult, causes of, 19 Sweat-glands, diseases of, 430 Sycosis, simple, 462 tinea, 486 Syphilis cutanea, 478 Syringo-myelia, 363 TABES dorsalis, 357 Tachycardia, 125 Taenia mediocanellata, .62 saginata, 62 solium, 62 Tape-worm, varieties of, 62 Teeth, Hutchinson's, 17 Temperature, subnormal, causes of. 235 Tetanus, 286 Tetany, 400 Thermo-anaesthesia, 321 Thomsen's disease, 401 Thrills, cardiac, causes of, 122 Thrombosis, cerebral, 345 Thrush, 24 Tic douloureux, 372 Tinea circinata, 486 favosa, 488 sycosis, 486 tonsurans, 485 versicolor, 487 Tinkling, metallic, 169 Tinnitus-aurium, causes of, 328 Titubation, 318 Tongue, condition of, in disease, 17 scars on, 18 tremor of, 18 Tonsillitis, 26 Tonsils, hypertrophy of, 28 Trance, 327 Tremors, causes of, 317 Trichina spiralis, 64 Trichinosis, 64 Tricocephalus dispar, 64 Tricuspid valve, diseases of, 138 Tumors, cerebral, 347 intestinal, 61 Tubercle bacillus, detection of, 159 Tuberculosis, acute general, 272 meningeal, 331 pulmonary, 216 Tubercules, cutaneous, causes of, 425 Typhlitis, 58 Typhoid fever, 237 Typhus fever, 243 Tyrosin in the urine, 87 ULCER, gastric, 40 perforating, of the foot, 325 Ulcers, cutaneous, causes of, 428 Uraemia, 96 Urates, increase of, 87 Urea, diminution of, 86 increase of, 86 test for, 86 Uric acid, test for, 86 Urine, albumin in, 92 bile in, 94 blood in, 93 chlorides in, 89 chyle in, 94 diminution of, 85 increase of, 85 indican in, 94 leucin in, 87 oxalates in, 89 phosphates in, 88 pus in, 95 sugar in, 90 tyrosin in, 87 urea in, 86 uric acid in, 86 Urobilinuria, 90 Urticaria, 437 VTACCINIA, 267 ' Vagabondismus, 415 Valvular affections of the heart, 135 Varicella, 266 Variola, 263 INDEX. 501 Varioloid, 265 Verruca, 468 Vertigo, 389 Vesicles, cutaneous, causes of, 420 Vitiligo, 458 Vocal cords, paralysis of, 155 Voice, loss of, 154 Vomit, varieties of, 20 Vomiting, causes of, 20 WART, 468 Wheals, causes of, 426 Whooping-cough, 278 Worms, intestinal, 62 Writers' cramp, 400 Wry-neck, 295 V ANTHOMA, 474 Y ELLOW fever, 270 ROSTER, herpes, 439 I MEDICAL AND SURGICAL WORKS' PUBLISHED BY W. 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Nancrede's Anatomy and Manual of Dissection Nancrede's Anatomy ..... Norris' Syllabus of Obstetrical Lectures Powell's Diseases of Children Saunders' Pocket Medical Formulary Saunders' Pocket Medical Lexicon Sayre's Practice of Pharmacy Semple's Pathology and Morbid Anatomy Semple's Legal Medicine, Toxicology, and Hygiene Senn's Syllabus of Lectures on Surgery Shaw's Nervous Diseases and Insanity . Stelwagon's Diseases of the Skin . Stevens' Practice of Medicine Stevens' Materia Medica and Therapeutics . Stewart and Lawrance's Medical Electricity Thornton's Manual of Prescription Writing * VlERORDT AND STUART'S MEDICAL DIAGNOSIS Wilson's Deformities of the Bones and Joints Wolff's Chemistry ....•• Wolff's Examination of Urine . i The works of authors indicated thus * are sold exclusively by subscription, further particulars of which and of these publications will be furnished promptly on application. The other books of this list will be mailed direct on receipt of their respective prices, or they can be procured from booksellers. For Sale by Subscription only. An American Text-Book of Surgery. Forming One Handsome Royal-Octavo Volume of over 1200 pages (10 x 7 inches), with nearly 500 Wood-cuts in Text, and 37 Colored and Half-tone Plates, many of them Engraved from Original Photographs and Drawings furnished by the Authors. Prices: Cloth, $7 net; Sheep, $8 net; Half Russia, $9 net. contributors: CHARLES H. BURNETT, M.D., Emeritus Professor of Otology, Phila- delphia Polyclinic. PHINEAS S. CONNER, M.D., LL.D., Professor of Surgery, Medical Col- lege of Ohio and Dartmouth Medical College. FREDERIC S. DENNIS, M D., Professor of Principles and Practice of Surgery, Bellevue Hospital Medical College. WILLIAM W. KEEN, M.D., LL.D., Professor of the Principles of Sur- gery and of Clinical Surgery, Jefl'erson Medical College. CHARLES B. NANCREDE, M.D., Professor of Surgery and of Clinical Surgery, University of Michigan. ROSWELL PARK, M D., Professor of Surgery, Medical Department of the University of Buffalo. LEWIS S. P1LCHER, M.D., Professor of Clinical Surgery in toe New York Post-Graduate School and Hospital. NICHOLAS SENN, M.D., Ph.D., Professor of Practice of Surgery and of Clinical Surgery, Rush Medical College. FRANCIS.!. SHEPHERD, M.D., CM., Professor of Anatomy and Lecturer on Operative Surgery, McGill University, Montreal, Canada. LEWIS A. STIMdOJ, BA, M.D., Professor of Surgery in the University ol the City ot New York. J WILLIAM THOMSON, M.D., Professor c' Ophthalmology, Jefferson Med- leal College. '" CUn,JvfrsitWARRRN' MD ' AsSOdate Professor of Surgery, Harvard J. WILLIAM WHITE VI.D., PH D., Professor of Clinical Surgery, Uni- versity oi Pennsylvania. ° *' EDITED BY WILLIAM W KEEN, M.D, LL.D., and J. WILLIAM WHITE, M.D., Ph.D. The want of a text-book which could be used by the practitioner and at the same time be recommended to the medical student has been deeply felt, especially by teachers of surgery. Hence, when it was suggested to a number of them that it would be well to unite in preparing a book of this description, great unanimity of opinion was found to exist, and the gentlemen before named gladly con- sented to join in its production. While there is no distinctive American Surgery, yet America has contributed very largely to the progress of modern surgery, and among the foremost of those who have aided in developing this art and science will be found the authors of the present volume. All of them are teachers of surgery in leading medical schools and hospitals in the United States and Canada. Especial prominence has been given to Surgical Bacteriology; a feature which is believed to be unique in a surgical text-book in the English language. Asepsis and Antisepsis have received par- ticular attention, and full details of the various methods of disin- fecting instruments, hands, and the field of operations, sutures, etc., will be found. The text is brought well up to date in such import- ant branches as cerebral, spinal, intestinal, and pelvic surgery, and the most important and newest operations in these departments are described and illustrated. The text of the entire book has been submitted to all the authors for their mutual criticism and revision, also an entirely new and original feature in book-making. The book, as a whole, therefore, expresses on all the important surgical topics of the day the con- sensus of opinion of the eminent surgeons who have joined in its preparation. One of the most attractive features of the book is its illustrations. Very many of them are original and faithful reproductions of pho- tographs taken directly from patients or from specimens, and the modern improvements in the art of engraving have enabled the publishers to produce illustrations which it is believed are superior to those in any similar work. 3 For Sale by Subscription only. AN AMERICAN TEXTBOOK ON THE Theory and Practice of Medicine. BY AMERICAN TEACHERS. Edited by WILLIAM PEPPER, M.D., LL.D., Provost and Professor of the Theory and Practice of Medicine and of Clinical Medicine in the University of Pennsylvania. Complete in Two Handsome Royal-Octavo Volumes of about lOOO pages each, with Illustrations to Elucidate the Text wherever Necessary. Price per vol., Cloth, $5 net; Sheep, $6 net; Half Russia, $7 net. VOLUME I. contains: Hygiene. J. S. Billings, Professor of Hygiene, University of Pennsylvania. Fevers (Ephemeral, Simple Continued, Typhus, Typhoid, Epidemic Cerebro-spinal Meningitis, and Relapsing). Wm. Pepper, M.D., Provost and Professor of the Theory and Practice of Medicine and of Clinical Medicine, University of Pennsylvania. Scarlatina, Measles, Rotheln, Variola, Varioloid, Vaccinia, Varicella, Mumps, Whooping-cough, Anthrax, Hydrophobia, Trichinosis, Actinomycosis, Glanders, and Tetanus. James T. Whittaker, M.D., Professor of the Theory and Practice of Medicine and of Clinical Medicine, Medical College of Cincinnati, O. Tuberculosis, Scrofula, Syphilis, Diphtheria, Erysipelas, Malaria, Cholera, and Yellow Fever. W. Gilman Thompson, ID., Professor of Physiology, New York University Medical College. Nervous, Muscular, and Mental Diseases (Including Opium Habit, etc.). Horatio C. Wood, M.D., Professor of Materia Medica, Pharmacy, and General Therapeutics, and Clinical Professor of Nervous Diseases, University of Pennsylvania. William Osler, M.D., Professor of Practice of Medicine, Johns Hop- kins University, Baltimore, Md. VOLUME II, contains: Urine (Chemistry and Microscopy). James W. Holland, M.D., Professor of Medical Chemistry and Toxi- cology, Jefferson Medical College, Philadelphia. Kidneys and Lungs. Francis Delapield, M.D., Professor of Pathology and Practice of Medicine, College of Physicians and Surgeons, New York City. Air-passages (Larynx and Bronchi) and Pleura. James C. Wilson, M.D., Professor of Practice of Medicine and of Clinical Medicine, Jefferson Medical College, Philadelphia. Pharynx, (Esopliagus, Stomach and Intestines (including Intestinal Parasites), Heart, Aorta, Arteries, and Veins. William Pepper, M. D., Provost and Professor of the Theory and Prac- ticeof Medicine and of Clinical Medicine, University of Pennsylvania. Peritoneum, Liver, and Pancreas. Reginald H. Fitz, M. D., Hersey Professor of Physics, Harvard Medi- cal School. Diathetic Diseases (Rheumatism, Rheumatoid Arthritis, Gout, Lithseniia, and Diabetes). Henry M. Lyman, M.D., Professor of Principles and Practice of Medicine, Rush Medical College, Chicago, 111. Blood and Spleen. William Osler, M.D., Professor of Practice of Medicine, Johns Hop- kins University, Baltimore, Md. Inflammation, Embolism, Thrombosis, Fever, and Bacteriology. W. H. Welch, M.D., Professor of Pathology, Johns Hopkins Uni- versity, Baltimore, Md. The articles are not written as though addressed to students in lectures, but are exhaustive descriptions of diseases with the newest facts as re- gards Causation, Symptomatology, Diagnosis, Prognosis, and Treat- ment, and they include a large number of approved Formulae. The re- cent advances made in the study of the bacterial origin of various dis- eases are fully described, as well as the bearing of the knowledge so gained upon prevention and cure. The subjects of Bacteriology as a whole and of immunity are fully considered in a separate section. Methods of diagnosis are given the most minute and careful attention, thus enabling the reader to learn the very latest methods of investigation without consulting works specially devoted to the subject. For Sale by Subscription only. AN AMERICAN TEXT-BOOK OP THE DISEASES of CHILDREN". INCLUDING Special Chapters on Essential Surgical Subjects; Diseases of the Eye, Ear, Nose, and Throat; Diseases of the Skin; and on the Diet, Hygiene, and General Management of Children. BY AMERICAN TEACHERS. EDITED BY LOUIS STAKE, M.D., Physician to the Children's Hospital and Consulting Pediatrist to the Maternity Hospital, Philadelphia; late Clinical Professor of Diseases of Children in the Hospital of the University of Pennsylvania, etc., etc., ASSISTED BY THOMPSON S. WESTCOTT, M. D., Attending Physician to the Dispensary for Diseases of Children, Hospital of the University of Pennsylvania, etc. Forming a handsome royal-8vo volume of nearly 1200 pages, profusely illustrated with wood-cuts, half-tone and colored plates. Prices: Cloth, $7.00; Sheep, $8.00; Half Russia, $9.00. ANNOUNCEMENT. An American Text-book of the Diseases of Children, which is a handsome royal-octavo volume of nearly 1200 pages, uniform with An American Text-book of Surgery, contains numerous wood-cuts, and full-page colored and half-tone illus- trative plates. The plan embraces a series of original articles written by some sixty well-known paediatrists, representing collectively the present teachings of the most prominent med- ical schools and colleges of America. The work is not intended to be encyclopaedic in character, but to be a practical book suitable for constant and handy reference by the practitioner and advanced student. One decided innovation for a book of its size is the large number of authors, nearly every article being contributed by a specialist in the line on which he writes. This, while entail- ing considerable labor upon the editors, has resulted in the publication of a work thoroughly new and abreast of the times. The entire work has been practically written in a few months, thus removing the usual objection to treatises of this class, that they are out of date before they are published. Especial attention is given to the consideration of the latest accepted teaching upon the Etiology, Symptoms, Pathology, Diagnosis, and Treatment of the disorders of children, with the introduction of many special formulae and therapeutic procedures. Special chapters embrace at unusual length the diseases of the Eye, Ear, Xose and Throat, and the Skin ; while the intro- ductory chapters cover fully the important subjects of Diet, Hygiene, Exercise, Bathing, and the Chemistry of Food. Tracheotomy, Intubation, Circumcision, and such minor sur- gical procedures coming within the province of the medical practitioner are carefully considered. For Sale by Subscription only. An American Text-Book of Gynecology MEDICAL AND SURGICAL. FOR THE USE OF STUDENTS AND PRACTITIONERS. BY JOHN M. BALDY, M.D., HENRY T. BYFORD, M.D., EDWIN CRAGIN, M.D., J. H. ETHERIDGE, M.D., WILLIAM GOODELL, M.D., HOWARD A. KELLY, M.D., FLORIAN KRUG, M.D., E. E. MONTGOMERY, M.D., WILLIAM R. PRYOR, M.D., GEORGE M. TUTTLE, M.D. Forming one handsome royal-8YO volume, profusely illustrated. Prices: Cloth, $6 ; Sheep, $7; Half Russia, $8. In this volume all anatomical descriptions, excepting those es- sential to a clear understanding of the text, have been omitted, the illustrations being largely depended upon to elucidate the anatomy of the parts. The work will be found thoroughly practical in its teach- ings, and is intended, as its title implies, to be a working text-book for physicians and students. A clear line of treatment has been laid down in every case, and although no attempt has been made to discuss mooted points, still the most important of these have been noted and explained. The operations recommended are fully illus- trated, so that the reader may have under his eye a picture of the procedure described in the text, and cannot fail to grasp the idea. All extraneous matter and discussions have been carefully ex- cluded, the attempt being made to allow nothing to cumber the text. The subject-matter has been brought fully up to date at every point, and the work is as nearly as possible the combined opinions of the ten specialists who figure as the authors. The work is well illustrated throughout with wood-cuts half- tone and colored plates, mostly selected from the authors' private collections. 8 For Sale by Subscription only. THIRD AND REVISED EDITION. MEDICAL DIAGNOSIS. By DR. OSWALD YIERORDT, Professor of Medicine at the University of Heidelberg ; formerly Privat Docent at University of Leipzig ; Professor of Medicine and Director of the Medical Polyclinic at the Univ. of Jena. Translated with additions, from the Second Enlarged German Edition, with the Author's Permission. By FRANCIS H. STUART, A.M., M.D., Member of the Medical Society of the County of Kings, N. Y.; Fellow of the New York Academy of Medicine ; Member of the •British Medical Association, etc. In One Handsome Royal-Octavo Volume of 700 Pages. 178 Fine Wood-cuts in Text, Many of Which are in Colors. Prices: Cloth, $4 net; Sheep, $5 net; Half Russia, $5.50 net. This Valuable Work is now Published in German, English, Russian, and Italian. In this work, as in no other hitherto published, are given full and accurate ex- planations of the phenomena observed at the bedside. It is distinctly a clinical work, (by a master teacher) characterized by thoroughness, fulness, and accuracy. It is amine of information upon the points that are so often passed over without explanations. Especial attention has been given to the germ theory as a factor in the origin of disease. The issue of a third edition within two years indicates the favor with which it has been received by the profession. PROFESSIONAL OFI3STI03STS. "One of the most valuable and useful works in medical literature." (Signed) ALEXANDER J. C. SKENE, M.D., Dean of the Long Island College Hospital, and Professor of the Medical and Surgical Diseases of Women. " Indispensable to both 'students and practitioners.' " (Signed) F. MINOT, M.D., Hersey Professor of Theory and Practice of Medicine, Harvard University, "It is very well arranged and very complete, and contains valuable features not usually found in the ordinary books. " (Signed) J. H. MUSSER, M.D., Assistant Professor Clinical Medicine, University of Pennsylvania. "A treasury of practical information which will be found of daily use to every busy practitioner who will consult it." (Signed) C. A. LINDSLEY, M.D., Professor of Theory and Practice of Medicine, Yale University, New Haven, Conn. 9 For Sale by Subscription only. DISEASES OF THE EYE. A Hand-Book of Ophthalmic Practice. By G. E. de SCHWEINITZ, MD., • Professor of Diseases of the Eye, Philadelphia Polyclinic; Professor of Clinical Ophthalmology, Jefferson Medical College, Philadelphia: Ophthalmic Surgeon to Children's Hospital and to the Philadelphia Hospital; Ophthalmologist to the Orthopaedic Hospital and Infirmary for Nervous Diseases; late Lecturer on Medical Ophthalmoscopy, University of Pa., etc. Forming a handsome royal-8vo. vol. of more than 660 pages. Over 200 fine wood-cuts, many of which are original, and two chromo-lithographic plates. Prices: Cloth, $4 net; Sheep, $5 net; Half Russia, $5.50 net. PROFESSIONAL OPINIONS. " A work that will meet with the requirements not only of the specialist, but of the general practitioner in a rare degree. I am satisfied that unusual success awaits it." (Signed) WILLIAM PEPPER, M.D., Provost and Professor of Theory and Practice of Medicine and Clinical Medicine in the University of Pennsylvania. '' Contains in concise and reliable form the accepted views of Ophthalmic Sci- ence." .(Signed) WILLIAM THOMSON, M.D., Professor of Ophthalmology, Jefferson Medical College, Philadelphia, Pa. "One of the best hand-books now extant on the subject." (Signed) J. 0. STILLSON, M.D., Professor of Eye and Ear, Central College of Physicians and Surgeons, Indianapolis, Ind. "Vastly superior to any book on the subject with which I am familiar." (Signed) FRANCIS HART STUART, M.D., Brooklyn, N. Y. "Contains in the most attractive and easily understood form just the sort of knowledge which is necessary to the intelligent practice of general medicine and Burgery." (Signed) J. WILLIAM WHITE, M.D., Professor of Clinical Surgery in the University of Pennsylvania. "A very reliable guide to the study of eye diseases, presenting the latest facts and newest ideas." (Signed) SWAN M. BURNETT, M.D. Prof, of Ophthalmology and Otology, Med. Department Univ. Georgetown, Washington D Q 10 Second Revised Edition. For Sale by Subscription only. A NEW PRONOUNCING DICTIONARY OF MEDICINE. WITH Phonetic Pronunciation, Accentuation, Etymology, etc. By JOHN M. KEATING, M.D., LL.D., Fellow of the College of Physicians of Philadelphia ; Vice-President of the American Paediatric Society; Ex-President of the Association of Life Insurance Medical Directors; Editor " Cyclopaedia of the Diseases of Children,'1 etc.; AND HENRY HAMILTON, Author of "A new Translation of Virgil's JSneid into English Rhyme;" Co-Author of " Saunders" Medical Lexicon," etc. WITH AN APPENDIX CONTAINING IMPORTANT TABLES OP BACILLI, MICROCOCCI, LEUCOMAINES, PTOMAINES ; DRUGS AS D MATERIALS USED IN ANTISEPTIC SURGERY ; POISONS AND THEIR ANTIDOTES; "WEIGHTS AND MEASURES ; THERMOMETRIC SCALES ; NEW OFFICINAL AND UNOFFICINAL DRUGS, ETC. ETC. Forming One very Attractive Volume of over 800 pages. Prices: Cloth, $5 net; Sheep, $6 net; Half Russia, $6.50 net. With Denison's Patent Index for Ready Reference. "I am much pleased with Keating's Dictionary, and shall take pleasure in recommending it to my classes." (Signed) HENRY M. LYMAN, M.D., Professor of Principles and Practice of Medicine, Rush Medical College, Chicago, III. "I am convinced that it will be a very valuable adjunct to my study table, convenient in size and sufficiently full for ordinary use." (Signed) C. A. LINDSLEY, M.D., Professor of Theory and Practice of Medicine, Medical Dept. Yale University, Secretary Connecticut State Board of Health, New Haven, Connecticut. "I will point out to my classes the many good features of this book as com- pared with others, which will, I am sure, make it very popular with students." (Signed) JOHN CRONYN, M.D, LL.D., Professor of Principles and Practize of Medicine and Clinical Medicine; President of the Faculty, Medical Dept. Niagara University, Buffalo, N. Y. " My examination and use of it have given me a very favorable opinion of its merit, and it will give me pleasure to recommend its use to my class." (Signed) J. W. H. LOVEJOY, M.D., Professor of Theory and Practice of Medicine, and President ofthe Faculty, ■ Medical Dept. Georgetown University, Washington, D. tl 11 Second Edition, for Sale by Subscription. AUTOBIOGRAPHY OF SAMUEL D. GROSS, M.D., D. C. L. OXON., LL.D. CANTAB., EDIN., JEFFERSON COLLEGE, UNIV. PA., EMERITUS PROFESSOR OF SURGERY IN THE JEFFERSON MEDICAL COLLEGE OF PHILADELPHIA. WITH REMINISCENCES OF HIS TIMES AND CONTEMPORARIES. Edited by his Sons, Samuel W. Gross, M.D., LL.D., late Pro- fessor of Principles of Surgery and of Clinical Surgery in the Jefferson Medical College, and A. Haller Gross, A.M., of the Philadelphia Bar. Preceded by a Memoir of Dr. Gross by the late Austin Flint, M.D., LL.D. In two handsome vols., each containing over 400 pages, demy 8vo, ex. cloth, gt. tops, with line Frontispiece engraved on steel. Price . . . $5.00 net. This Autobiography, which was continued by the late eminent Surgeon until within three months before his death, contains a full and accurate history of his early struggles, trials, and subse- quent successes, told in a singularly interesting and charmino- man- ner, and embraces short and graphic pen portraits of many of the most distinguished men—surgeons, physicians, divines, lawyers, statesmen, scientists, etc. etc—with whom he was brought in con- tact in this country and in Europe ; the whole forming a retrospect of more than three-quarters of a century. 12 SAUNDERS' SERIES OF MANUALS FOE STUDENTS AND PRACTITIONERS. The aim of the Publisher is to furnish, in this Series of Manuals, a number of high-class works by prominent teachers who are con- nected with the principal Colleges and Universities of this country ; the position and experience of each being a guarantee of the sound- ness and standard of text of the subject on which he writes. Especial care has been exercised in the choice of large, clear, read- able type ; a high-grade of slightly-toned paper, of a shade particu- larly adapted for reading by artificial light; high-class illustrations, printed in colors when necessary to a clear elucidation of the text; and strong, attractive, and uniform bindings. The prices vary from $1.50 to S2.50 per volume, it being deemed un- desirable to fix an arbitrary standard and pad the volumes accordingly. Now Ready—Fourth Editton. CONTAINING "HINTS OlST IDISS'BCTIOlsr." Essentials of Anatomy and Manual of Practical Dissection. By CHARLES B. NANCREDE, M.D., Professor of Surgery aDd Clinical Surgery in the University of Michigan, Ann Arbor; Corresponding Member of the Koyal Academy of Medicine, Rome, Italy; late Surgeon Jefferson Medical College, etc. etc. With Handsome Full-page Lithographic Plates in Colors. Over 200 Illustrations. No pains nor expense have been spared to make this work the most exhaustive yet concise Student's Manual of Anatomy and Dissection ever published, either in America or in Europe. The colored plates are designed to aid the student in dissecting'the muscles, arteries veins and nerves. For this edition the woodcuts have all been specially drawn and engraved, and an Appendix added containing 60 illustrations repre- senting the structure of the entire human skeleton, th whole based on the eleventh edition of Gray's Anatomy, and forming a handsome post-8vo. volume of over 400 pages. Price, Extra Cloth or Oilcloth for the Dissection-Room, $2.00 net. 13 SECOXZ) EBITIOIC. A Manual of the Practice of Medicine. By A. A. STEVENS, A.M., M.D., Instructor of Physical Diagnosis in the University of Pennsylvania, and Demonstrator of Pathology in the Woman's Medical College of Philadelphia. Post-8vo, 502 pages, Illustrated. Price, Cloth, $2.50. Contributions to the science of medicine have poured in so rapidly during the last quarter of a century, that it is well-nigh impossible for the student, with the limited time at his disposal, to master elaborate treatises, or to cull from them that knowledge which is absolutely essential. From an extended experience in teaching, the author has been enabled by classification, the grouping of allied symptoms, and the judicious elimination of theories and redundant explanations, to bring within a comparatively small compass a com- plete outline of the Practice of Medicine. A Manual of Medical Jurisprudence AND TOXICOLOGY. By HENRY CHAPMAN, M.D., Professor of Institutes of Medicine and Medical Jurisprudence in the Jefferson Medical College, Philadelphia; Member of the College of Physicians, Philadelphia,etc. 232 pp., post-octavo, with 36 Illustrations, some of which are in colors. Price $1.25 Net. For many years there has been a demand from members of the medical and legal professions for a medium-sized work on this most important branch of medicine. The, necessarily prescribed limits of the work per- mit only the consideration of those parts of this extensive subject which the experience of the author as coroner's physician of the city of Phila- delphia for a period of six years leads him to regard as the most material for practical purposes. Particular attention is drawn to the illustrations, many being produced in colors, thus conveying to the layman a far clearer idea of the more in- tricate cases. 14 SAXTNDERS' Pocket Medical Formulary BY WILLIAM M. POWELL, M.D., Attending Physician to the Mercer House for Invalid Women at Atlantic City. CONTAINING 1750 Formulae, selected from several hundreds of the best-known authorities. Forming a handsome and convenient Pocket Companion of nearly 300 printed pages, and blank leaves for additions. WITH AN APPENDIX Containing Posological Table; Formulae and Doses for Hypo- dermic Medication: Poisons and their Antidotes; Diam- eters of the Female Pelvis and Foetal Head; Obstet- rical Table ; Diet List for various aiseases; Materials and Drugs used in Antiseptic Surgery : Trea-tment of Asphyxia from Drowning; Surgical Hemembraneer; Tables of Incompatibles; Eruptive Fevers; Weights and .erasures, etc. Third Edition, Revised and greatly Enlarged. Handsomely bound in Morocco, with Patent Index, Wallet, and Flap. Price, $1.73 net. Therapeutic Gazette,......—" The prescriptions have been taken from the writings or practice of Physician? whose experience qualifies them to be worthy of trial. We heartily recommend this volume to all who desire to purchase New York Medical Recoed........—" This little book, that can be conveniently carried in the pocket, contains an immense amount of material. It is very useful, and, as the name of the author of each prescription is given, is unusually reliable." THIRD EDITION. How to Examine for Life Insurance. By JOHN M. KEATING, M.D., Medical Director Penn Mutual Life Insurance Co.; Ex-President of the Association of Life Insurance Medical Directors; Consulting Physician for Diseases of Women at St. Agnes' Hospital, Phila.; Gynaecologist to St. Joseph's Hospital, etc. With two large Phototype Illustrations, and a Plate prepared by Dr. McClellan from special Dissections; also, numerous cuts to elucidate the text, Price, in Cloth, $2.00. PART I. has been carefully prepared from the best works on physical diagnosis, and is a short and succinct account of the methods used to make examinations ; a description of the normal condition, and of the earliest evidences of disease. PART II. contains the instructions of twenty-four Life Insurance Com- panies to their medical examiners. PRESS NOTICES. " The most practical manual on this subject that has yet been offered as a guide to the medical examiner for life insurance. It contains much that is needful in the way of reference that cannot be found grouped elsewhere."—Buffalo Medical and Surgical Journal. " Just sueh a book as the young and inexperienced medical examiner needs."— The American Journal of the Medical Sciences. " By far the most useful book which has yet appeared on insurance examination. The book should be at the right hand of every physician interested in this special branch of medical science."—The Medical News. "The volume is replete with information and suggestions, and is a valuable con- tribution to the literature of the medical department of life underwriters' work." —The United States Review (Insurance Journal). In Active Preparation. Ready Shortly. A MANUAL OF SURGERY, GENERAL AND OPERATIVE. BY JOHN CHALMERS DA COSTA, M. D., Instructor in Surgery, Jefferson Medical College. A new manual of the Principles and Practice of Surgery, intended to meet the growing demand of students and others for a medium-sized work which will embody all the newer methods of procedure detailed in the larger text-books. 16 NURSING: Its Principles and Practice, FOR HOSPITAL AND PRIVATE USE. By ISABELLA A. HAMPTON, Graduate of the New York Training School for Nurses attached to Bellevue Hospital Superintendent of Nurses and Principal of the Training School for Nurses, Johns Hopkins Hospital, Baltimore, Md.; Late Superintendent of Nurses, Illinois Training School for Nurses, Chicago, Illinois. Price, $2.00 net. An entirely new work on the important subject of nursing, at once comprehensive and systematic. It is written in a clear, ac- curate, and readable style, suitable alike to the student and lay reader. It is of especial value to the graduated nurse who desires to acquire a practical working knowledge of the care of the sick and hygiene of the sick-room. Thoroughly tested and approved processes in practical nursing only have been given, particularly in antiseptic surgery. Illustrations have been freely used wherever necessary to elucidate the text. A MANUAL OF Materia Medica and Therapeutics. BY A. A. STEVENS, A.M., M.D., Instructor of Physical Diagnosis in the University of Pennsylvania and Demonstrator of Pathology in the Woman's Medical College of Philadelphia. 435 pages. Price, Cloth, $2.25. This entirely new and valuable volume on the important subjects of "Materia Medica and Therapeutics" is based upon the 1890 edition of the Pharmacopoeia. The work is divided into the following sections: 1. Physiological Action of Drugs. 2. Drugs, including their source, composition and description, therapeutic application, and administration; also the incompatibles. 3. Kemedial Measures other than Drugs, as counter-irritation, hydro- therapy, electricity, etc. 4. Applied Therapeutics. The whole is elucidated by more than 200 formulae. Explicit directions are given for prescribing the doses both in the Apothecaries' and the Metric Systems. Considerable space is devoted to the newer remedial agents. A. SYLLABUS OF Lectures on the Practice of Surgery. ARRANGED IN CONFORMITY WITH THE AMERICAN TEXT-BOOK OF SURGERY. By N. SENN", M.D., Ph.D., Professor of Surgery in Rush Medical College, Chicago, and in the Chicago Polyclinic. PRICE . . . $2.00. This the latest work of its eminent author, himself one of the contributors to the " American Text-Book of Surgery," will prove of exceptional value to the advanced student who has adopted that work as his text-book. It is not only the syllabus of an unrivalled course of Surgical Practice, but an epitome or supplement to the larger work. Notes on the Newer Remedies, THEIR Therapeutic Applications and Modes of Application By DAVID CERNA, M.D., Ph.D. Demonstrator of and Lecturer on Experimental Therapeutics in the University of Pennsylvania. Forming a small octavo volume of about 175 pages (7 x 5) inches. PRICE - - - $1.25, The work takes up in their alphabetical order all the Newer Remedies, giving their physical properties, solubility, therapeutic applications, ad- ministration, and chemical formulae. It will in this way form a very valuable addition to the various works on Therapeutics now in existence. Chemists are so multiplying compounds that if each compound is to be thoroughly studied, investigations must be carried far enough to deter- mine the practical importance of the new agents. 8AUNDEE8' POCKET MEDICAL LEXICON; OR, Dictionary of Terms and Words used in Medicine and Surgery. By JOHN M. KEATING, M.D., Editor of " Cyclopaedia of Diseases of Children," etc.; Author of the "New Pronouncing Dictionary of Medicine," AND HENRY HAMILTON, Author of "A New Translation of Virgil's iEneid into English Verse;" Co-author of a " New Pronouncing Dictionary of Medicine." Price, 75 Cents, Cloth. $1.00, Leather Tucks. " Saunders' Pocket Medical Lexicon—a very complete little work, invaluable to every student of medicine. It not only contains a very large number qf words, but also tables of etymological factors common in medical terminology; abbre- viations used in medicine, poisons and antidotes, etc."—Annals of G-yncecology, Philadelphia. IN ACTIVE PBEPARATION. METHODS OF PREVENTING AND CORRECTING Deformities of the Bones and Joints. A Handbook of Practical Orthopaedic Surgery. By II. AUGUSTUS WILSON, M.D., Professor of General and Orthopaedic Surgery, Philadelphia Polyclinic; Clinical Professor of Orthopaedic Surgery, Jefferson Medical College, Philadelphia, etc., etc. The aim of the author will be to provide a book of moderate size, contain- ing comprehensive details that will enable general practitioners to thor- oughly understand the mechanical features of the many forms of congenital and acquired deformities of the bones and joints. Mechanical and operative procedures will be given in detail, and promi- nence will be given to the mechanical requirements for braces and artificial limbs, etc., with description of their methods of construction. A large number of original illustrations will be used to make descriptions clearer. 19 DISEASES OF WOMEN. By HENRY J. GARRIGUES, A.M., M.D., Professor of Obstetrics in the New York Post-Graduate Medical School and Hospital: Gynaecologist to St. Mark's Hospital, New York City; Gynae- cologist to the German Dispensary in the City of New York ; Con- sulting Obstetrician to the New York Infant Asylum; Obstetric Surgeon to the New York Maternity Hospital; Fellow of the American Gynaecological Society ; Fellow of the New York Academy of Medicine; President of the German Medical Society of New York, etc. etc. [n One Very Handsome Octavo Volume, of about 700 pages, profusely Illustrated by Woodcuts and Colored Plates. PRICES: CLOTH, $4.00; SHEEP, §5.00. A practical work on Gynaecology for the use of students and practitioners, writ- ten in a terse and concise manner. The importance of a thorough knowledge of the anatomy of the female pelvic organs has been fully recognized by the author, and considerable space has been devoted to the subject. The chapters on opera- tions and on treatment are thoroughly modern, and are based upon the large hospital and private practice of the author. The text is elucidated by a large number of illustrations and colored plates, many of them being original. SYLLABUS OE OBSTETRICAL LECTURES In the Medical Department University of Pennsylvania. By RICHARD C. N ORRIS, A.M., M.D., Demonstrator of Obstetrics in the University of Pennsylvania. Third Edition, thoroughly revised and enlarged. PRICE, CLOTH (INTERLEAVED FOR NOTES) $2.00 Net. The New York Medical Record.......referring to this book, says : " This modest little work is so far superior to others on the same subject that we take pleasure in calling attention briefly to its excellent features. Small as it is, it covers the subject thoroughly, and will prove invaluable to both the student and the practitioner as a means of fixing in a clear and concise form the knowledge derived from a perusal of the larger text-books. SECOND EDITION READY. AN OPEEATION BLANK, Will List of Instruments, etc. rehired in various Operations. Prepared by W. W. KEEX, M.D., LL.D., Professor of the Principles of Surgery in the Jefferson Medical College, Philadelphia. Price per Pad (containing Blanks for 50 Operations) 50 Cents, net. A convenient blank, suitable for all operations, giving complete instructions re- garding necessary preparation of patient, etc., with full list of dressings and medi- cines to be used. Saunders' Question Compends. Now the Standard Authorities in Medical Literature WITH Students and Practitioners in every City of the United States and Canada. THE REASON WHY! They are the advance guard of " Student's Helps"—that do help ; they are the leaders in their special line, well and authoritatively written by able men, who, as teachers in the large colleges, know exactly what is wanted by a stu- dent preparing for his examinations. The judgment exercised in the selection of authors is fully demonstrated by their professional elevation. Chosen from the ranks of demonstrators, quiz-masters, and assistants, host of them have become professors and. lecturers in their respective Colleges. Each book is of convenient size (5 by 7 inches), containing on an aver- age 250 pages, profusely illustrated and elegantly printed in clear, reada- ble type, on fine paper. The entire series, numbering twenty-three subjects, has been kept thoroughly revised and enlarged when necessary, many of them being in their third and fourth editions. TO SUM UP. Although there are numerous other Quizzes, Manuals, Aids, etc., in the market, none of them approach the " Blue Series of Question Compends," for which the following points of excellence are claimed: 1. Professional distinction and reputation of authors. 2. Conciseness, clearness, and soundness of treatment. 3. Size of type, and quality of paper and binding. **# Any of these Compends will be mailed on receipt of price. No. 1. ESSENTIALS OF PHYSIOLOGY. By H. A. HAKE, M.D., Professor of Therapeutics and Materia Medica in the Jefferson Medical College of Philadelphia; Physician to St. Agnes' Hospital and to the Medical Dispensary of the Children's Hospital; Laureate of the Royal Academy of Medicine in Belgium, of the Medical Society of London, etc.; Secretary of the Convention for the Revision of the Pharmacopoeia, 1890. Crown-8vo, 230 pages, numerous illustrations. Third Edition, revised and enlarged by the addition of a series of hand- some plate-illustrations taken from the celebrated " Icones Nervorum Capitis" of Arnold. Price, Cloth, $1.00 net. Interleaved for notes, $1.25 net. " Dr. Hare has admirably succeeded in gathering together a series of Questions which are clearly put and tersely answered."—University Medical Magazine. No. 2. ESSENTIALS OF SURGERY. CONTAINING, ALSO, Venereal Diseases, Surgical Landmarks, Minor and Operative Surgery, and a Complete Description, together with full illustrations, of the Handkerchief and Roller Bandage. By EDWARD MARTIN, A.M., M.D., Clinical Professor of Genito-Urinary Diseases, Instructor in Operative Surgery, and Lecturer on Minor Surgery, University of Pennsylvania; Surgeon to the Howard Hospital; Assistant Surgeon to the University Hospital, etc. etc. Fifth edition. Crown-8vo, 334 pages, 90 illustrations. Considerably enlarged by an Appendix containing full directions and prescriptions for the preparation of tlie various materials used in ANTISEPTIC SURGERY ; also several hundred recipes covering the medical treatment of surgical affections. Price, Cloth, $1.00. Interleaved for Notes, $1.25. "Dr. Martin has admirably succeeded in selecting and retaining just what ia necessary for purposes of examination, and putting it in most excellent shape for reference and memorizing."—University Medical Magazine. 22 No. 3. ESSENTIALS OF ANATOMY, Including the Anatomy of the Viscera. By CHARLES B. NANCREDE, M.D., Professor of Surgery and Clinical Surgery in the University of Michigan, Ann Arbor; Corresponding Member of the Royal Academy of Medicine, Rome. Italy; Late Surgeon Jefferson Medical College, etc. etc. Fifth edition. Crown-8vo, 380 pages, 180 illustrations. Enlarged by an Appendix containing over Sixty Illustrations of the Osteology of the Human Body. The whole based upon the last (eleventh) edition of GRAY'S ANATOMY. Price, Cloth, $1.00. Interleaved for Notes, $1.25. "Truly such a book as no student can afford to be without."—American Prac- titioner and News, Louisville, Kentucky. No. 4. Essentials of Medical Chemistry ORGANIC AND INORGANIC. CONTAINING, ALSO, Questions on Medical Physics, Chemical Physiology, Analytical Processes, Urinalysis, and Toxicology. By LAWRENCE WOLFF, M.D., Demonstrator of Chemistry, Jeffersoa Medical College; Visiting Physician to German Hospital ol Philadelphia; Member of Philadelphia College of Pharmacy, etc. etc. Fourth and revised edition, with au Appendix. Crown-8vo, 212 pages. Price, Cloth, $1.00. Interleaved for Notes, $1.25. " We could wish that more books like this would be written, in order that medi- cal students might thus early become more interested in what is often a difficult and uninteresting branch of medical study."—Medical and Surgical Reporter. " The author is thoroughly familiar with his subjects. A useful addition to the medical and pharmaceutical library."—Registered Pharmacist, Chicago. No. 5. ESSENTIALS OF OBSTETRICS. By W. EASTERLY ASHTON, M.D., Professor of Gynaecology in the Medico-Chirurgical College of Philadelphia; Obstetrician to the Philadelphia Hospital. Third Edition, thoroughly revised and Enlarged. Crown-8yo, 244 pages, 75 illustrations. Price, Cloth, $1.00. Interleaved for Notes, $1.25. "An excellent little volumecontaining correct and practical knowledge. An admi- rable compend, and tha best condensation we have seen."—Southern Practitioner. "Ashton's Obstetrics. Of extreme value to students, and an excellent little book to freshen up the memory of the practitioner."—Chicago Medical Times. "A work thoroughly calculated to be of service to students in preparing for ex- amination."—Medical and Surgical Reporter. "Ashton's Obstetrics should be consulted by the medical student until he can answer every question at sight. The practitioner would also do well to glance at the book now and then, to prevent his knowledge from getting rusty."—New York Medical Abstract No. 6. ESSENTIALS OF Pathology and Morbid Anatomy. BY C. E. ARMAND SEMPLE, B.A., M.B., Cantab., L.S.A., M.R.C.P., Lond., Physician to the Northeastern Hospital for Children, Harkney; Professor of Vocal and Aural Physiology and Examiner in Acoustics at Trinity College, Loudon, etc. etc. Crown-8vo, 46 illustrations, 174 pages. Price, Cloth, $1.00. Interleaved for Notes, $1.25. " An excellent compend of the subject from the points of view of Green and Payne. "—Indiana Medical Journal. "A valuable little volume—truly a multum in parvo."—Cincinnati Medical Jfews. 34 No. 7. essentials of Materia Medica, Therapeutics, a:nt> prescription writing. By HENRY MORRIS, M.D., Late Demonstrator, Jefferson Medical College; Fellow College of Physicians, Phila- delphia; Co-editor Biddle's Materia Medica; Visiting Physician to St. Joseph's Hospital, etc. etc. Fourth Edition. Crown-8vo., 250 pages. Price, Cloth, $1.00. Interleaved for Notes, $1.25. " One of the best compends in this series. Concise, pithy, and clear, well suited to the purpose for which it is prepared.''—Medical and Surgical Reporter. "The very essence of Materia Medica and Therapeutics boiled down and pre- sented in a clear and readable style."—Gaillard's Medical Journal. " A well-arranged quiz-book, comprising.the most important recent remedies."— Sanitarium, New York. "The subjects are treated in such a unique and attractive manner that they cannot fail to impress the mind and instruct in a lasting manner."—Buffalo Med. icaland Surgical Journal. Nos. 8 and 9. Essentials of Practice of Medicine. By HENRY MORRIS, M.D., Author of " Essentials of Materia Medica," etc. etc. With an Appendix on the Clinical and Microscopical Examination of Urine. By LAWRENCE WOLFF, M.D., Author of" Essentials of Medical Chemistry," etc. Colored (Vogel) Urine Scale and numerous fine Illustrations. Third Edition, enlarged by some Three Hundred Easential Formula, selected from the writings of the most eminent authorities of the Medical Profession. Collected and Arranged by WILLIAM M. POWELL, M.D., Author of" Essentials of Diseases of Children." Post-8vo., 460 pages. Prices: Clotli, $2.00 j Medical Sheep, $2.50. " Of material aid to the advanced student in preparing for his degree, and to the young practitioner in diagnosing affections or selecting the proper remedy."— Southern Practitioner. " The teaching is sound, the presentation graphic, matter as full as might be desired, and the style attractive."—American Practitioner and News. No. 10. ESSENTIALS OF GYNECOLOGY. By EDWIN B. CRAGIN, M.D., Attending Gynaecologist, Roosevelt Hospital, Out-Patients' Department) Assistant Surgeon, New York Cancer Hospital, etc. etc. THIRD EDITION. Crown-8vo, 198 pages, 62 fine illustrations. Price, Cloth, $1.00. Interleaved for Notes, $1.25 •'This is a most excellent addition to this series of question compends, and prop- erly used will be of great assistance to the student in preparing for examination. Dr. Cragin is to be congratulated upon having produced in compact form the Essen- tials of Gynaecology. The style is concise, and at the same time the sentences are well rounded. This renders the book far more easy to read than most compends, and adds distinctly to its value."—Medical and Surgical Reporter. "Students and practitioners, general or special, even derive information and benefit from the perusal and study of a carefully written work like this."— College and Clinical Record. No. 11. Essentials of Diseases of the Skin. By HENRY W. STELWAGON, M.D., Clinical Lecturer on Dermatology in the Jefferson Medical College, Philadelphia; Physician to the Skin Service of the Northern Dispensary: Dermatologist to Philadelphia Hospital; Physician to Skin Department of the Howard Hospital; Clinical Professor of Dermatology in the Woman's Medical College, Philadelphia, etc. etc. SECOND EDITION. Crown-8vo, 262 pages, 75 illus., many of which are original Price, Cloth, $1.00. Interleaved for Notes, $1.25. " We are indebted to Philadelphia for another excellent book on Dermatology. The little book now before us is well entitled 'Essentials of Dermatology,' and admirably answers the purpose for which it is written. The experience of the reviewer has taught him that just such a book is needed. We are pleased with the handsome appearance of the book, with its dear type, good paper, and fine woodcuts."—N»w York Medical Journal. 26 No. 12. ESSENTIALS OF Minor Surgery, Bandaging, AND Venereal Diseases. By EDWARD MARTIN, A.M., M.D., Author of " Essentials of Surgery," etc. SECOND EDITION, REVISED AND ENLARGED. Crown-8ro, 158 pages, 78 illustrations, mostly specially prepared for this work. Price, Cloth, $1.00. Interleaved for Notes, $1.25. " The best condensation of the subjects of which it treats yet placed before the profession. The chapter on Genito-Urinary Diseases, though short, is sufficiently complete to make them thoroughly acquainted with the most advanced views on the subject.'1—Medical News, Philadelphia. No. 13. ESSENTIALS OF Legal Medicine, Toxicology, and Hygiene. By C. E ARMAND SEMPLE, M.D., Author of " Essentials of Pathology and Morbid Anatomy." Crown-8vo, 212 pages, 130 illustrations. Price, Cloth, $1.00. Interleaved for Notes, $1.25. "At the present time, when the field of medical science, by reason of rapid pro- gress, becomes so vast, a book which contains the essentials of any branch or de- partment of it, in concise, yet readable form, must of necessity be of value. This little brochure, as its title indicates, covers a portion of medical science that is to a great extent too much neglected by the student, by reason of the vastness of the entire field and the voluminous amount of matter pertaining to what he deems more important departments. The leading points, the essentials, are here summed up systematically and clearly."—Southern Practitioner, Nashville. " A fair sample of Saunders' valuable compends for the student and practitioner. It is handsomely printed and illustrated, and concise and clear in its teachings."— Medical Brief', St. Louis. .27 No. 14. ESSENTIALS OF Refraction and Diseases of the Eye. By EDWARD JACKSON, A.M., M.D., Professor of Diseases of the Eye in the Philadelphia Polyclinic and College for Graduates in Medicine, etc. etc. AND Essentials of Diseases of the Nose and Throat. Br E. BALDWIN GLEASON, M.D., Surgeon in charge of the Nose, Throat, and Ear Department of the Northern Dispensary; Assistant in the Ear Department of the Philadelphia Polyclinic and College for Graduates in Medicine, etc. etc. Two vols, in one, Crown-8vo, 294 pages, 124 illustrations. SECOND EDITION, REVISED ASD ENLARGED. Price, Clotli, $1.00. Interleaved for Notes, $1.25. " A valuable book to the beginner in these branches, to the student, to the busy practitioner, and as an adjunct to more thorough reading. The authors are capable men, and as successful teachers know what a student most needs.1'—New York Medical Record. No. 15. ESSENTIALS OF DISEASES OF CHILDREN. By WILLIAM M. POWELL, M.D., Attending Physician to the Mercer House for Invalid Women at Atlantic City N. J • Late Physician to the Clinic for the Diseases of Children in the Hospital o'f "' the University of Pennsylvania and St. Clement's Hospital, etc. etc. CROWN-8VO, 216 PAGES. Price, Cloth, $1.00. Interleaved for Notes, $1.25. "This work is gotten up in the clear and attractive style that characterizes the Saunders' Series. It contains in appropriate form the gist of all the best works in the department to which it relates."—American Practitioner and News Louisville, Ky. " Dr. Powell's little book is a marvel of condensation. Handsome binding, good paper, and clear type add to its attractiveness."—Southern Practitioner, Nash- ville, Tenn. " The book contains a serie3 of important questions and answers, which the stu- dent will find of great utility in the examination of children. "—Annals of Guncs- oology, Philadelphia. 9 88 No. 16. ESSENTIALS OF EXAMINATION OF URINE. By LAWRENCE WOLFF, M.D., Author of" Essentials of Chemistry," etc. COLORED (VOGEL) URINE SCALE AND NUMEROUS ILLUSTRATIONS. Crown-8vo. Price, Cloth, 75 Cents. " A little work of decided value."—University Medical Magazine. " A good manual for students, well written, and answers, categorically, many questions beginners are sure to ask."—Medical Record, New York. " The book is practical in character, comprehensive as is desirable, and a useful aid to the student in his studies. "—Memphis Medical Monthly, Memphis, Tenn. No. 17. ESSENTIALS OF DIAGNOSIS. By SOLOMON SOLIS-COHEN, M.D., Professor of Clinical Medicine and Applied Therapeutics in the Philadelphia Polyclinic, AND , AUGUSTUS A. ESHNER, M.D, Instructor in Clinical Medicine, Jefferson Medical College, Philadelphia. Post-8vo, 382 pages. 55 Illustrations, some of which are Colored, and a Frontispiece. Price, $1.50 net. " A good book for the student, properly written from their standpoint, and con. fines itself well to its text."—Medical Record, New York. "Concise in the treatment of the subject, terse in expression of fact. . . The work is reliable, and represents the accepted views of clinicians of to-day."— American Journal of Medical Sciences. "The subjects are explained in a few well-selected words, and the required ground has been thoroughly gone over."—InternationalMeiical Magazine. "We can heartily recommend this work; it is modern and complete, and will give more satisfaction than many other works which are perhaps too prolix as well aa behind the times."—Medical Review, St. Louis. 26 No. 18. ESSENTIALS OF PRACTICE OF PHARMACY. By LUCIUS E. SAYRE, Professor of Pharmacy and Materia Medica in the University of Kansas. Second Edition, Eevised and Enlarged; Grown-8vo, 200 pages. Price, Cloth, $1.00. Interleaved for Notes, $1.25. " Covers a great deal of ground in small compass. The matter is well digested and arranged. The research questions are a valuable feature of the book."— Albany Medical Annals, Albany, N. Y. "This very valuable little manual covers the ground in a most admirable manner. It contains practical pharmacy in a nutshell."—American Doctor, Richmond, Va. "The best quiz on pharmacy we have yet examined. "—.ZVataoraa/ Drug Register, St. Louis, Mo. " A book of only 200 pages, but pharmacy in a nutshell. It is not a quiz-corn- pend compiled to enable a grocery clerk to ' down' a board of pharmacy; it is a finger-post guiding a student to a completer knowledge."—Western Drug Record. No. 20. Second and Revised Edition. ESSENTIALS OF BACTERIOLOGY. A CONCISE AND SYSTEMATIC INTRODUCTION TO THE STUDY OF MICRO-ORGANISMS. By M. Y. BALL, M.D., Assistant in Microscopy, Niagara University, Buffalo, N. Y.; Late Resident Physician German Hospital, Philadelphia, etc. Crown-8vo, 200 pp. 81 Illns. and five Plates, some in Colors. Price, Cloth, $1.00. - - Interleaved for Notes, $1.25. '' The amount of material condensed in this little book is so great, and so accu- rate are the formulae and methods, that it will be found useful as a laboratory hand-book."—Medical News, Philadelphia. "Bacteriology is the keynote of future medicine, and every physician who ex- pects success must familiarize himself with a knowledge of Germ-life—the agents of disease. •'This little book with its beautiful illustrations will give the students, in brief, the results of years of study and research unaided. "^-Pacific Record of Mtdtcim and Surgery, San Fc&noisoo. 30 No. 21. ESSENTIALS OF Nervous Diseases and Insanity. THEIK SYMPTOMS AKD TREATMENT. By JOHN C. SHAW, M.D., CliDical Professor of Diseases ot the Mind and Nervous System, Long Island College Hospital Medical School; Consulting Neurologist to St. Catharine's Hospital, and Long Island College Hospital; Formerly Medical Superin- tendent King's County Insane Asylum. SECOND EDITION. Crown-8vo, 186 pages. 48 Original Illustrations. Mostly selected from the Author's private practice. Price, Cloth, $1.00. Interleaved for Notes, $1.25. "Clearly and intelligently written."—Boston Medical and Surgical Journal. " A valuable addition to this series of compends, and one that cannot fail to be appreciated by all physicians and students."—Medical Brief, St. Louis. " Dr. Shaw's Primer is excellent as far as it goes, the illustrations are well exe- cuted and very interesting."—Times and Register, New York and Philadelphia. No. 22. ESSENTIALS OF PHYSICS. By FRED J. BROCKWAY, M.D., Assistant Demonstrator of Anatomy at the College of Physicians and Surgeons, New York. Crown-8vo, 320 pages, 155 fine illustrations. Price, Cloth, ------ $1.00 net. Interleaved for Notes, _ - - - $1.25 net. " The publisher has again shown himself as fortunate in his editor as he ever has been in the attractive style and make-up of his compends."—American Prac- titioner and News, Louisville, Ky. "Contains all that one need know of the subject, is well written, and is copiously illustrated."—Medical Record, New York. " The author has dealt with the subject in a manner that will make the theme not only comparatively easy, but also of interest."—Medical News, Philadelphia. No. 23. Essentials of Medical Electricity. By D. D. STEWART, M.D., Demonstrator of Diseases of the Nervous System and Chief of the Neurological Clinic in the Jefferson Medical College ; Physician to St. Mary's Hospital, and to St. Christopher's Hospital for Children, etc. AND E. S. LAWRANCE, M.D., Chief of the Electrical Clinic and Assistant Demonstrator of Diseases of the Nervous System in the Jefferson Medical College, etc. Crown-8vo, 148 pages, 65 illustrations. Price, Cloth, $1.00. Interleaved for Notes, $1.25. "Clearly written, and affords a safe guide to the beginner in this subject."— Medical and Surgical Journal, Boston. "The subject is presented in a lucid and pleasing manner."—Medical Record, New York. " A little work on an important subject, which will prove of great value to med- ical students and trained nurses who wish to study the scientific as well as the practical points of electricity."—The Hospital, London, England. In Preparation. Ready Shortly. A DOSE-BOOK AND Manual of Prescription Writing. By E. Q. THORNTON, M.D., Demonstrator of Therapeutics, Jefferson Medical College, Philadelphia. The volume, in size and general appearance, will be uniform with "Saunders' Pocket Medical Formulary." 32 NATIONAL LIBRARY OF MEDICINE NLM DDlDMbDM D NLM001046040