Oct. 24-41 Dear Michael, At last I have had time to read and study your wonderful papers. Of course I don't grasp all of the work [...] what I do get seems [...] a thrilling story. I want to ask you one or two questions (1) Is it not true that Paulings idea was of a very simply -- physical -- change from normal U antibodies globulin --just- [END PAGE ONE] [BEGIN PAGE TWO] a bending at the two ends of a chain -- whereas your concept involves a more fundamental chemical change at several points in the molecule (2) Doesn't your concept stress more than ever the element of time necessary for the cells to elaborate -- the multivalent effection antibodies -- that is to say the low grade--[...]-- antibody [...] be the first [END PAGE TWO] [BEGIN PAGE THREE] attempt of the cell and the multivalent the further evolution of the process. (3) Does the presence of actin complement [. . .] a more effective antigen-antibody reaction -- that is [. . .] a physiological part of the mechanism -- or just a [. . .] These will all seem pretty stupid questions to you -- at any rate I seem vaguely [. . .] what a wonderful field for future [END PAGE THREE] [BEGIN PAGE FOUR] experimentation your quantitative methods have opened up. Isn't "Fess" perfectly [. . .]? I have been asked by the Medical [. . .] here to give a little talk about the cellular [. . .]. If the work -- and I am in [. . .] whether I [. . .] or not -- and if I do whether I wait until I have been East again and [. . .] things over with you. I shall be in as usual in January for [. . .]and [. . .] Guggenheim once more. I [. . .] this year [END PAGE FOUR] [BEGIN PAGE FIVE] [. . .] since she is in New York instead of me. I keep on agonizing [. . .] with short intervals of respite -- for [. . .] cannot keep up the tension [. . .] It was pretty bad a few days when it seemed as if Moscow was to fall soon -- but now the Russians seem to be holding up and [. . .] will soon help. I have very great [END PAGE FIVE] [BEGIN PAGE SIX] Faith in the English [. . .] rear this new collection of Hitler's addresses. I think it's more important from the standpoint of understanding him [. . .] Mein Kampff. I [. . .] when [. . .] book is coming out. I hope that Hanna is quite well again and send her [. . .] my love. With many thanks Florence