U.S. Department ea eC isieerare| Human Services National Institutes of Health February 18, 2003 Vol. LV, No. 4 Varmus Portrait Dedicated in Bldg. 1 By Rich McManus hree years after leaving directorship of NIH to head Memorial Sloan-Kettering Cancer Center in New York City, Dr. Harold Varmus returned on Jan. 15 for the formal unveiling of his portrait—a tradition observed by all past NIH directors. At a Wilson Hall ceremony attended by many of his former colleagues and recruits, Varmus gave an art history lesson explaining the portrait, which includes him in the foreground, seated and looking gregari- ous in an open-collared shirt, and a prominent backdrop featuring a famous painting, executed by Jacques Louis David in 1788, of French scientist Antoine Laurent Lavoisier and his wife Marie Anne Pierrette Paulze. The Varmus portrait is the work of SEE VARMUS PORTRAIT UNVEILED, PAGE 6 Former NIH director Dr. Harold Varmus shares his observations about new portrait in Bldg. 1. nr — ares 8 Toke fmm] = fod Food | ae ’ Varmus chats with NIH director Dr. Elias Zerhouni and former NIMH director Dr. Steven Hyman (c) at the event; Hyman, now provost at Harvard Univer- sity, spoke candidly about Varmus’s tenure as NIH director. PHOTOS: JOHN CRAWFORD VARMUS PORTRAIT UNVEILED. CONTINUED FROM PAGE 1 artist Jon R. Friedman, whose renderings of former National Academy of Sciences president Dr. Frank Press and of Dr. Maxine Singer, an NCI scientist who now heads the Carnegie Institution of Washing- ton, had impressed Varmus. Friedman spoke briefly at the ceremony, also attended by Varmus’s wife Connie Casey, who unveiled the artwork. NIH director Dr. Elias Zerhouni emceed the affair, and read a letter from former Rep. John E. Porter . (R-IIL.), a prominent the agency’s congres- sional appropriations committee, who could not attend. Porter’s letter hailed Varmus as the model and “gold standard” of an NIH director, and praised his organizational skill—“closely analo- gous to herding cats.” Even greater than Varmus’s success winning large NIH budgets from Congress, Porter said, was his ability to achieve “vastly increased public awareness of the benefits of science.” Offering more of a traditional roast of the day’s honoree was Dr. Steven Hyman, whom Varmus recruited to direct NIMH, and who now is provost B friend of NIH while on at Harvard University. “So what do you say about a man who is truly larger than life?” he began. Hyman said NIH appeared, at least from an extra- mural perspective, to be in the doldrums prior to Varmus’s arrival in 1993. “With Harold’s arrival, things really seemed to change quickly and with an upward trajectory that I don’t think anyone could have predicted.” Hyman said Varmus’s great gift was an insistence on quality science and its benefits for society. “He believed in talking honestly and directly, with no funny business...Nothing is more effective than frank communication. “The thing about Harold,” he continued, “is that he is relentlessly about content.” Varmus was rather less tolerant of the minutiae and procedure of bureaucracy, Hyman added. “When that stuff came up, his eyes glazed over and a look of boredom and disapproval swept over his face...If you were so dense that you didn’t know your conversation with him was over, he’d give another hint by going over to his desk and reading his email. “Harold was all about high standards and being honest about what good science was—this, and his integrity, made him a great boss. Harold always protected your back. Even remarkably radical reforms could go forward (under his direction), if they bettered science. He really made the job of being an institute director incredibly rewarding.” Varmus and Zerhouni stand beside the finished work, which features Varmus sitting before a famous old painting by French artist Jacques Louis David. Hyman praised Varmus’s skills as a recruiter, noting that candidates should have interpreted it a a sign of respect when Varmus met them while still dripping wet from exercise, or when Varmus took them to Bethesda’s no-frills restaurants for recruit- ment pitches. He noted that, under Varmus, “the necktie was demoted at NIH as a symbol of polite dress.” Hyman concluded, “Harold was all about sub- stance, content, high quality science, and he was entirely unapologetic about it. He wasn’t about marketing or making compromises. His tenure led to enormous morale and camaraderie. That sense? Just after Varmus announced bis intention, in fall 199] to leave NIH, some colleagues put up a mock portrait featuring artwork tl had accompanied a New Yorker feature on Varmus. The proto-portrait only remained on view fo several days. putting science first was such a positive influence, and a spectacular asset for NIH and the America people.” Zerhouni then spoke of how influential Varmus had been in helping him to decide to take NIH’s directorship. He divulged that he at first turned _ down the position, but reconsidered when the House approached him again. Zerhouni won an exception to the White House rule barring nomin¢ from talking with anyone about their job offer; “l told them I needed to talk to Harold Varmus abot. it, and they agreed. We met at the Harvard Club® New York, and those hours were very influential,’ qethouni said. “Ninety-five percent of what he told we turned out to be true.” ~gechouni said Varmus’s major strength was winning bipartisan support for NIH. He created a te harbor for politicians at NIH. They can meet with no overriding political stress.” Zerhouni id one Could measure Varmus’s status by the amber of new buildings he launched, or by his fort to double the budget within 5 years, but ted another way to measure the outcome of his ure: “What if the director’s portrait changed in relative to his or her accomplishments?” he tjon R. dman spoke ‘briefly at the ceremony. His portraits of other scientific leaders prompted Varmus to select him for bis own official portrait. wondered. “The portraits would range in size from postage stamps to frescoes. And you, Harold, would cover all the wall downstairs.” Vammus then took the podium, thanking everyone for attending. “This is a very happy event for me, in patt because I really like this portrait...I didn’t expect tosay that. I’m also glad that it hangs here, not me.” He credited NIH with turning him into a scientist, while he served as a clinical associate here from 1968 t0 1970 as a way of avoiding the Vietnam war. He then described why the background portrait of lavoisier—-“founder of modern chemistry and reductionist science” —was important to him. “The panting celebrates science in four ways,” he said: it «mphasizes the connection between science and art; ithighlights the relationship between science and Words (Lavoisier can be seen working on his Traité eementaire de Chimie or Elementary Treatise on emistry presented in a New Order according to Modern Discoveries, published on Jan. 17, 1789); it tepicts the benefits of science and marriage; and it “ows the relationship of science to politics 4voisier was a member of the French ruling class). Yamus concluded that it was important to him t the portrait “puts me in the backdrop of my iimage.” He noted, ironically, that both he and ‘orginal David portrait occupy opposite ends of “8 St. in New York—his apartment is at one end, itd the Metropolitan Museum of Art, which “lays the roughly 7x9-foot portrait, is at the other. Vane guests enjoyed a reception in Wilson Hall, the 24s portrait was installed on the first floor of Ng. 1, just outside the director’s office. o |