John E. Bruno 1404-54th St. Kenosha, WI March. 23-'62 Drs. Nirenberg and Matthaei. Bethesda Md. Dear Drs. In my April issue of Science Digest an article was written on the wonderfull [sic] work use are doing on genetics and Metabolic Diseases. Now the reason I write is to inquire of a metabolistic [sic] problem I have, Albinoism. In the article it states of the work uses are doing on herditary [sic] Materials DNA and RNA. In your experiments have you found the cause of Albinoism? Have uses done any experiments with Albino mice? Is there any way of inducing pigment formations? My name is John E. Bruno. I am of Italian extraction. I have 20/200 vision. I have ben [sic] to a number of Oculist [sic] and their diagnosis is of the same pattern a lack of pigment in the retina. My O.D. has not ben [sic] able to give me any anatomical improvement. Is there a chemical that can be induced [sic] in the blood stream to stain the retina? Over Please [END PAGE ONE] [BEGIN PAGE TWO] Drs. I have an experiment which would be very interesting to work with! Understanding that the retina is a continuation of the brain and being a very complex mechanism to work with! My experiment deals with employing charged particles of chemicals that would be exceptable [sic] to tissue. Using a screen and a plate. The screen is charged and the solid metal plate being of opposite polarity from that of the screen Placing the chemicals in front of the screen the chemicals particles become charged and are drawn to the plate. The retina being between the chemical and plate becomes impergnated [sic]. [diagram] Hoping to receive an answer to this letter I remain Yours Truly John E. Bruno 1404-54th St. Kenosha, Wisconsin