40427 / THE UNIVERSITY OF MICHIGAN MEDICAL SCHOOL TELEPHONE: DEPARTMENT OF HUMAN GENETICS ANN ARBOR, 764-5490 1137 E. CATHERINE STREET ANN ARBOR, MICHIGAN 48104 April 6, 1973 Dr. Joshua Lederberg Department of Genetics Stanford University Medical School Palo Alto, California Dear Josh: It seems that you, Sir Otto, and Gunther Stent are the speakers on the Symposium which I will chair on "Genetics in Human Affairs" at the Berkeley Congress. When you get around to outlining your presentation, I would appreciate some indication of its general thrust. Sir Otto is fairly pre- dictable, but Stent is not. In view of our recent exchange of letters, to what extent will you be countering a point of view which Stent may be expected to develop. I might say that with respect to my opening remarks, I expect to present the point of view that for the foreseeable future, the human geneticist should not regard himself as a knight in shining armor riding out to transmute bad genes, but a member of a team trying to define how genetic factors contribute to disease and then with his peers considering how we develop a culture that minimizes the expression of these genetic predispositions and gives each of our unique phenotypes the squarest shake possible. Best regards, James V. Neel, M.D. Ce Lee R. Dice University Professor pt of Human Genetics \