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THE WISTAR INSTITUTE

THIRTY-SIXTH STREET AT SPRUCE
PHILADELPHIA 4, PA.

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HILARY KOPROWSKp) M.D. PHONE: BARING 2-6700
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February 22, 1 962 CABLE ADDRESS: WISTARINST

Dr. Joshua Lederberg
Department of Genetics
Standford University
Medical Center

Palo Alito, California

Dear Josh:

Charles Tyroler and Ralph Lapp were here last Wednesday.
We spent a very pleasant hour or so in conversation, discussing problems
which you and I talked over while I was in Palo Alto. The visit was quite
pleasant and very interesting but I don't think it lead anywhere as far as
more practical consideration of our discussions are concerned. They
invited me to stop in their office again when I am in Washington and I
shall certainly do so. They may perhaps communicate to you more about
their future plans concerning their interests in pharmaceutical, biological
and "tabacum!" fields.

I have received a reply from the Surgeon General to the letter
which I have sent to him and I am forwarding a copy of this to you. Itisa
semi-satisfactory reply although he does seem to take away the stigma of
"exclusiveness" of using certain strains only for the preparation of polio-
virus vaccines.

LY SAI day hey yy

I had an interesting visit with J. F. A. P. Miller (an unusual
combination of initials for a Frenchman raised in Australia; he was probably
given J. F. at birth and A. P. were added during his Australian sojurn). He
showed data on animals thymectomized as newborns which apparently failed
on many occasions to react to a homograft or heterograft. We are studying
such animals from the point of view of auto-sensitization but, as yet, the
results are not very convincing. However, we may not have a complete
thymectomy. We will repeat these experiments. It would be really fun
if it can be shown that a mammal, thymectomized at birth, cannot be sen-
sitized.
THE WISTAR INSTITUTE PHILADELPHIA 4, PA.

Dr. Joshua Lederberg February 22, 1962

won

Best personal regards to you and Esther.

yours,

i Hilary Koprowski, M.D,
,/ Di or

    

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