OAK RIDGE NATIONAL LABORATORY OPERATED BY UNION CARBIDE NUCLEAR COMPANY DIVISION OF UNION CARBIDE CORPORATION cS POST OFFICE BOX Y OAK RIDGE, TENNESSEE September 14, 1959 Prof. Joshua Lederberg Department of Genetics Stanford University Stanford, California Dear Professor Iederberg: At the meeting on Basic Research at The Rockefeller Institute, Jim Watson from Harvard and I got together and discussed what could be done to get some more basic information on low level effects of radiation in relation to leukemia, toxicity of Strontium 90, genetical induction, and especially to determine if there is a threshold of very low levels of radiation. We know these are very tough and complicated problems, but they are so urgent that we feel they should be discussed for the purpose of determining at least if some reasonable experiments can be set up as a beginning to the study of them. Most of us have been worrying about these problems for a long time, and I think the time has come that something should be done. With the approval of Dr. Bronk and under the auspices of the National Academy of Sciences, we are now calling a small group together to discuss the possibility of formulating a plan for acquiring definite information on these problems. We would like to invite you most cordially to join this meeting which has been scheduled for October 30 and 31 in Washington, D.C. Your travel expenses in connection with this meeting will be taken care of by funds which have been set aside by the National Research Council, according to their policies. We will give you more details as to location, time and reimbursement as soon as we know if you will be with us. Please let me know as soon as possible whether we can count on you. Attached is a list of invitees to this meeting. Best personal regards, Sincerely yours, (llat— (eh an Alexander Hollaender Biology Division prd: Phy. a) Bean LEck 4— com ete a ™. SP 2. awed gu @K- 2h, AH:mjl Enclosure Invitees to October 30-31 Meeting Beadle, G. W. Brues, A. M. Dulbecco, R. Dunham, Charles Hicks, Samuel Hollaender, Alexander Kaplan, Henry S. law, Lloyd W. lederberg, Joshua lewis, Edward B. Luria, 5. E. Rogers, Stanfieh Russell, W. L. Upton, A. C. Watson, J. D. Zelle, Max R. California Institute of Technology - Argonne National Laboratory California Institute of Technology + U.S. Atomic Energy Commission New England Deaconess Hospital Oak Ridge National Laboratory Stanford University School of Medicine ¢ National Cancer Institute Stanford University California Institute of Technology « University of Illinois University of Tennessee Memorial Research Center Oak Ridge National Laboratory Oak Ridge National Laboratory Harvard University U.S. Atomic Energy Commission BIOLOGY DIVISION OAK RIDGE NATIONAL LABORATORY ORGANIZATION OF RESEARCH CYTOLOGY AND MAMMALIAN GENETICS RADIATION PROTECTION — NUCLEIC ACID CHEMISTRY PLANT PHYSIOLOGY AND GENETICS AND DEVELOPMENT LIVING CELLS PHOTOSYNTHESIS Paramecium Section Chief Alexanderffjollaender* 5 W. E. Cohn Plant Physiology Tradescantia W.L. Russell G. E. Stapletd . F. J. Botlum Vicia H. |. Adler J. X. Khym A. H. Haber Hordeum Genetic Effects of M. S. Engel Neurospora Radiation in Mice A. Marie McCarthy Photosynthesis Maize Phage Elizabeth M. Kelly W. A. Arnold L. Wickham NUCLEIC ACID ENZYMOLOGY R. F. Kimball J hine S. G 4 0. Carolyn Wells! osepnine 9. lower PATHOLOGY AND S. Wol ff PHYSIOLOGY E. Volkin D. Davidson? Effects of Radiation on L. Astrachan BIOPHYSICS D. Schwartz Mammalian Gametogenesis Section Chief / th Barbara A. Swomley! A. C. Upton J. S. Kirby-Smit D. R. Kri E. F. Oakberg J. Jagger . R. Krieg D. M. Green! . CHEMICAL PROTECTION M. L. Randolph F. J. de Serres Developmental Effects of Pathological Effects AND H. G. Kglmark? Radiation in Mice of Radiation PROTEOLYTIC ENZYME STUDIES B. B. Webber! . G.E.C Liane B. Russell - &. Cosgrove V. C. Monesi2 W. H, Benedict* , D. G. Doherty BIOMETRICS Grasshopper and Habrobracon c 7 ‘io F.C. Grimm! (Mathematics Panel) . . . 1st Owicz Mary E. Gaulden Mammalian Cytogenetics U. H. Ebling? A. W. Kimball D. M. Prescott W. J. Welshons M. A. Kastenbaum R. C. von Borstel? E.H. Y. Chu Physiologica! and ENZYMOLOGY J. G. Carlson4 ysiological an Anna R. Whiting! Chemical Effects G. D. Novelli K. B. Jacob T. T. Odell, Jr. ET.Kenney BIOLOGY LIBRARY Drosophila MAMMALIAN RECOVERY W. Friedberg R. J. Mans R. A. Popp H. D. Peck, Jr Li D. L. Lindsley Hematopoietic Recovery oO. Vv. Muderri soglu? M. P. Stulberg . (ORNL Library Branch) E. H. Grell a B Nicoletti? C. C. Congdon C.J. Wust Minnie B. Duncan \ i 4 Electron Microsco R. W. Bernlohr® Rhoda F. Grell4 R. R. Bigelow Py G. Doria? T. Kameyoma M. B. Lion? E. B. Darden, } Charlotte R. Lea! S. Rogers! D. F. Parsons Mary-Lowell B. Taylor! O. Vos? W.H. Taylor, Jr! *Division Director Bone Marrow Physiology L. H. Smith Joan W. Goodman Histology and Autoradiography W. D. Gude K. Tonomura? Tissue Culture M. A. Bender T. T. Phan? Animal Breeding and Maintenance T. W. McKinley, Jr. J.C. Kile, Jr.4 MICROBIOLOGY S. F. Carson** R. K. Clayton M. I. Dolin? E. F. Phares RADIATION IMMUNOLOGY T. Makinedan N. Gengozian E. H. Perkins E. E. Capalbo? F. Celada? R. D. Owen4 Isabel C. Shekarchi* CELL PHYSIOLOGY N. G. Anderson P. Mazur H. E. Bond! B. T. Cole® E. C. Horn4 **Assistant Division Director Research Associate 2Visiting Investigator from Abroad 3Leave of Absence, NSF Senior Postdoctoral Fellowship, Pavia, italy 4Consultant >Research Participant SUSPHS Fellow 7Leave of Absence, Guggenheim Fellowship, Paris, France