ISTITUTO SIEROTERAPICO MILANESE “SERAFINO BELFANTI” ENTE MORALE AGGREGATO ALLA UNIVERSITA DI MILANO Direttore Scientifico: Prof. Augusto De Barbieri Via Darwin, 20 - MILANO Laboratori di Ricerche TELEFONO =. 224d & linee) My dear Joshua, Dec, 29,1956 thank you for your letter of Dec.18, just received. We have had direct news of yours from Magni,who is just back (and full of enthousiasm for .merica,too.I am not surpised .Incidental- ly: I have given your name as a reference on submitting an applica- tion to U.of California, Berkeley, Hope you don't mindx. Here the Situation has not improved considerably,and a good offer at this stage might turn me into aniixgy immigrant to the U.S-). I am enclosing a first trial on chapter tI.As you will see,I have greatly altered the preliminary (and poor) scneme, and incorporrkated most or 411° our suggestions. I have tried to give one(or few) examples for each case;choices may not always be opti- Mai,and interpretations open to objections. The torm is still very rough and I hope you will pay your attention to contents only;I hope I can 10 better On a second writing,when your further sugges+ stions will $e arrived, irobably there is much that can be deleted; thougn it may be worth wasting a little time and space on clarity, peebably more than I have done sofar,if the book is to be useful, say ,to medical students.I Suppose that an analysis of the kind we havein mind might be useful in some University courses kept at a level higner than average.Publishers would certainly be BUBiinna pleased with it,anyhow, prepare and Unfortunately, IT have no, time, to/send you, the Ki st of referencesgxkiz 7 wanted to keep my word but have now to dedicate my time to the ARM review,and the references are not yet all on cards;some of them ,morevoer are mixed with those of the ARM review. You will howeverknoy directly or indirectly7,all of the works quoted, Perhaps the number of references is excessive,at least in this pre- liminary chapter.It can easily be cut down, On practising it,I have found the foilowing method for references comfortable, Ali references of a given cnaapter are numbered from one, onwards,and the Same number is written on the corres onding pate B as Setter cor- responding to the particular chapteee At shone Se REF, & work, all , cards will be otiered alphabetically and renumbered progress ive1 yf ,7°° the: ordered again by chapter and progressive number within the be HEATER BaP vac oluon muates in She aaa eeee eee et Bee ypescript,which will thus ve reaay for the press, I hope this does not sound confusing, or obvious. In any ease, I think there is something to be said for alpnabetical Ordering of references,and for saving space in the text by using numbers for referring to them, . I hope you will prepare some nice photographs of penicillin protoplests for chapter 5 ISTITUTO SIEROTERAPICO MILANESE “SERAFINO BELFANTI’” ENTE MORALE AGGREGATO ALLA UNIVERSITA DI MILANO Direttore Scientifico: Prof. Augusto De Barbieri Via Darwin, 20 - MILANO Laboratori di Ricerche TELEF ON Os. 35.74.44 Lines) what about your programues for =urope and ‘ustralia next year? thank you for your list of data from Demerec's tahles, T had to stop doing any work on transduction analysis;but hope to be able to start ag2in ,as soon as the AR’ review will be finished (must be in the publisher's hands by Jan 31), . AS an aduition to your chapter IV ; there is a polymorphism in tne Negro race for response tc: the drug primaguine,ang anti- malarial. You will find tarious papers on tnesubject by Dern,and ~ by Beutler, on J.lab.Clin, Med. 1954, 4 fairly rare defect of pseudochulinesterase was found by Lehmann, but baxgxaak I have no literature on it at the moment, Two new polymorphisms in man were recently found by Allison ; excretion of unaltered ped—beet pigment and methytatien-of-asperasua, production of mehtyimercaptans ~~ trom asparagus, Ali tne best , Yours Banca Jerry .