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Dear Lage: io ae. vo agg ome |
T havé-Just’ hadvailetter: Prosi Chesser): ab- Pawlia, asking ££ we eould:. -
accomoda te’ BlVi0-'-Fachinell4’ next year as’ a visitng fellow. fw would com. —

as a Rotaby Club échdlar.
“oN VTP oe ne? OG

3!

SOT BE pp Ob

Unfortihately;* we abe already’ committed to. the makiamm,” an® shert of —
a chance to have you visit us yourselves (for which we would move the: moun
tains), I do not see any possibility of having him in our laboratory. (We
have already assigned, as visitors, two Danes [the Grskovs], one Finn and
one German (Heugann) and Newton Morton, as postddoctoral fellows, not two
mention only three graduate students (one Australian, one Japanese, and one
New Yorker-— what a polyglot group!). There are howeverg three possibilities
in regard to Fachinelli that I would like to ask your advice about; Prof.
Checcacci asks for a prompt reply on my part, and therefore I ask the same of
you:

1. Simple regrets.

2. Place Fachinelli with another group on campus, @e8+e, JB Wilson in
Bacteriology Department, with whom I have close affiliation; he would then
probably see us two or three times a week.

3. Suggest postponement until next year. (While it is now too late for
56-58, I do not want to make definite commitments just yet for '57-58, unless
he has outstanding merit and interest. There is just a possibilit >» not yet
nearly verified, that we might take a trip for a few months to Australia
§Rubbo) next year, in which case we shall try to circumnavigate the globe and
see you en route: it is not yet settled just when (or if) we should make this
trip, but it is a factor in not wanting to mke too rigid plans.

Whatever you know, can find out, or can advise about Fachinelli, I would
be very grateful to hear.

We enjoyed your card from Sicily. Just when is Magni coming?

We have also done some poor experiments comparable to yours on F+/Hfr
relationships, but not really very decisive. My own effeorts have been mainly
to recover the male parent from mxmammx the recombinant clones 9@-8., the
Lac+ prototrophs from Hfr/F+ M-Lac+ x F—~ Lac-. But I have not been able to
recover the Hfr inpit in more than 20-30% of such clones (for technical
reasons), so do not have much reliance on the very infrequnt isolation of
Hfr from similar experiments with F+ x F~. One problem is that some Hfr's
very likely are still infective for F, though they apparently do not transmit
the Hfr quality in this way. This infec tivity may be due to instability of
ifr —, F¥,;-a° point being exaiiined.” Anohg ‘the hew HIt's there are a couple
Which “ate promising as not eliminating any’ of the tested markers, hut they
have notibeen sufficiently anvestigated. @ 6 oe elie

So your paper in J. Genetics finally did come out} If you could spase
another 3-4 copies, there is at least that much demand for it here, and my

students would be grateful. You asked about writing: it
is a terrible chore..“I hope you are not losing any sleep over the book, but
I also hope you can tend to it omce in a while. Other news here: Bradley

(who was working on Streptomyces heterokaryons, and does not yet find
recombination’ (a. la:Sermonti) in his strains is leaving thie fall fan an
taking an appointment here in a new program at the Medical School as an
Assistant Professor "of Anatomy and Human Genetics"; the anatomy, I hope
is only a formality. This is a very encouraging development, and one I
have been eager for for a long time. I hope it will proceed further,

but there is naturally some conservatism in the adoption of nm a new
subjec t. While Morten!s background is primarily matabmatical (e.g.
linkage in man) he is anxious to get an experimental program underway.
So next year he will do laboratory work with us-- will probably take

up the Lac allelism problem which Fsther had built up, and which is
amenable to mich more detailed analysis.with Hfr-crossing, diploida, etc.
Actually, 1 have been.somwhat: surprised. that the: Lae,- + mutations. of.
Y-87 and Y~53 continhee to behave as alleles even undér tather stringent.
screening, with which the non~allelism of W-112, Lac b? is readily shown.
In the Sal’ series, Ne! * have zat: to enepunter. & det init gase: of- precise |:

     

 

  

 

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Our. paper should appear inthe May Lesue, i.e. about midJune. To avoid:
confusion, it probably would help Lf. you would: also communicate. with.

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