WALTER REED ARMY INSTITUTE OF RESEARCH
WALTER REED ARMY MEDICAL CENTER
WASHINGTON 12, D.C.

IN REPLY REFER TO:

 

September 21, 1959

Dear Joshua:

As things are, and unfortunately, they may never change, there is: the most
compelling reason for not considering the origin of this strain. I
hoped to be able to allude to this as much as I am able, thinking that I
would see you at the SS meeting here. Unhappily, I = 4earned recently
that you had left the group, and so I waited to hear from you by mail.

All I can say is that we did not refrain from going into the background
of this material by choicd. I cannot emphasize that too strongly, but
there are extremely pertinent reasons which make it impossible for us to
do otherwise, However, the general results do not have to be held back,
and I think this is fortunate since this may be a very useful tool¥ 1
might also add that one could hardly disaggree with the reasons involved,

As regards your point about a camplete or rounded account, I had thought
that there might be an appropriate symposium at CSH or elsewhere which
might fit the bill. If not, we would look to do this for Genetics or de Bacte

In reference to your comment pg.5 and table l, Ty2 Lact is a male as a
result of the cross with ST-2, but is also now able to act as a female in a
cross with W1895 as male, In such crosses previously, (wate) x Ty2, Ty2
was sterile (F°). There is only a negligible frequency of to F™ in
K~l2 x Ty2 detectable using Lac, and none using leAra; after ST<-2 x Ty2
selected on Lac, there is a readily detectable frequency for the cross,

K-12 x Ty2 Lac+ leAra~ selected on leAra, yielding Ty2 LaceAra+ (still Hfr).
I will try to clarify this in the MS, or perhaps I am missing the point of
your commnente

About the generality of the effect- almost all Sailmonella and Shigella cross
with ST-2, amd as far as we have tested, these are now able to act in a manner
identical to ST#2 (usually).

One of my associatesis leaving for a position in industry, and I wonder if
you might know of someone at the recent PhB level who might be available?

Thanks a lot for your helpful comments. Best regards to Esther.

Sincerely,
doer

nM a _— eS. BARON a,
A fous seaouraton as anticly anclesthaclatl, ard i prafeall 8 onpld fells

HOM |