CABLE ADDRESS "MOTA" IN YOUR REPLY PLEASE QUOTE FILE NO. _ 2.2 ATOMIC ENERGY OF CANADA LIMITED CHALK RIVER PROJECT CHALK RIVER, ONT. December 9, 195 Dr. Joshua Lederberg Department of Genetics The University of Wisconsin College of Agriculture Madison 6, Wisconsin Dear Joshua: Many thanks for your letter. Im extremely pleased that you have someone on the recombination problem in actinomycetes. If he could get recom- bination it would be most useful. Pontecorvo tells me that G. Sermonti of the Instituto Superiore di Sanita, Rome has attempted to get Streptomyces heterocaryons but I have no idea how successful he has been. Lillian Wainwright, who has done some heterocaryon work with nutritional mitants has also tried hyphal tip isolations, but she will write to you separately. I have no cnance myself to do this sort of study so please do not have any worries as to the possible overlap. With best wishes, Yours sincerely, / a vowed HBN: kp H. B. Newcombe