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Biology Division
Janyary 18, 1952

Dr, J, Lederberg

Dept. of Genetics

The University of Wisconsin
College of Agriculture
Madison 6, Wisconsin,

Dear Josh:

My apologies for not having answered vou note of Dec. g sooner,
The truth of the matter is that I honed that perhaps I might get a couple
of experiments done and meke this test which you suggested, but
things have gotten too rushed, We are leaving this afternoon for a trip
to California (Caltech), and I have simply had too many things to
get ready.

I can only say that it certainly would be feasible to test whether
a lysis inhibited culture can be induced to lyse by mild UV doses. In fact,
I would manckwionky expect that clesring could be brought about. In this
connection, I would also expect that standard non-inhibited cultures would
probably be induced to lyse by UV, if treated at a time when they contain
mature phage particles, Almost any poison wil! bring this about,

Therefore I suspect that the things in common between lysogenicity and
lysis inhibition would perhaps only be en expressioh of the things thet
all phage systems, whether lysis-inhibited, lysogenic, or rapidly lysing,
have in common,

I mmx have recently vrganized my data on reconbination in T4, and, like
Hershey, have found that a linesr picture does not fit, I am thinking in
terms of a two-dimensional distribution of genetic markers in phage,

I would like to recall the details of your "branched chromosome" or whatever
it has become, Would it be possible to obtain a maommmex copy of your

CSH manuscript{ or anything later) which describes the data and the
proposed hypothesis? I woudl need only the section conteining that perticular
material, If this would be possible, could you send it to me at Caltech,
(Kerckhoff), or here if it were sent later than Féb, 14,

J wovld appreciate seeing this information very much,

Best regards to you, Esther, the Morse family, and Ebhelyn,

Sincerely

Keo

A, H, Doemann