Lv ow FEB NT 1987 D 10 Questionnaire I. Verification (Part 1) The panel (N = 19) gave the following responses to the question, “Do you think that it is possible for the United States to monitor the development, production, or stockpiling of microbial agents in another country? , YES NO NOT ANSWERED Development: ~- 5 ll 3 Production: 8 8 3 Stockpiling: 8 9 2 Your response to this question was: Net Net Development: No Production: Arnweerd Stockpiling: prswered The following reasonable measures were specified by the panel as a means to monitor development, production, or stockpiling of microbial agents in another country. Please place an *x* In the space provided to indicate your judgment of the effectiveness of the measure for monitoring development, production or stockpiling. Note: E = effective, NE = not effective, ? = do not know. EFFECTIVENESS OF MEASURE FOR MONITORING DEVELOPMENT PRODUCTION STOCKPILING MEASURES E NE ? T = NE | ? Et NE| ? a) open-inspections (international teams, L on-site, & on demand) ) intelligence gathering y ~ c) monitoring of research “| “ — _ id) defectors w ” a je) sampling (technical means " to detect microorganisms) w A ve i £) self-inspection Y. ” 7 9) international cooperation] ” 1! "| Please reconsider and respond to the question: "Do you think that it is possible for the United States to monitor the development, production, or stockpiling of microbial agents in another country? Development? Production? ~ Stockpiling? Yes No 7 Yes No Yes No 2? Comments about this page: Ctfective vs Ue Ne Shans 5 , Tyo ey row - G. " lopansmentihel cia tonnes ver Spf Ia. Verification (Part 2) The panel (N = 19) gave the following responses to the question: Do you think it is possible to monitor an incident of BW use? YES: 14 NO: 4 NOT ANSWERED: 1 Your response to this question was Yes . The following reasonable measures were specified by the panel as a means to monitor an incident of BW use. Please place an "x" in the space provided to indicate your judgment of the effectiveness of the measure for monitoring BW use. Please indicate if you believe the measure would be effective for monitoring small scale and large scale use of BW. Note: E = effective, NE = not effective, ? = do not know. EFFECTIVEN . MEASURES FOR MONITORING BW USE SMALL SCALE USE LARGE SCALE USE MEASURES : E ‘NE ? E NE ? a) epidemiologic — — investigations Ib) medical examination of casualties — MK“ jcy site inspections < ral dj) sampling (technical means to detect organisms v — at a site) e) analysis of organism A Wa and "vehicle" ZL => = > : ~~ ) international committee am g) intelligence gathering — ) international inspection ~~ 4 teams | Please reconsider and respond to the question: Do you think it is possible to monitor an incident of BW use? Yes No Comments about this page: amen nk fess oeceas 6 Suaprteng otee II. Secrecy (Part 1) The issue of secrecy in BW research in the United States arose from the first questionnaire. When you answer questions in this Survey regarding secrecy in BW research, are you assuming a) the U.S. does conduct secret BW research, or b) the U.S. does not conduct secret BW research? Does Does not . The following statements were made by panelists in the first round questionnaire. Please indicate (by placing an "x" in the space provided) if you agree or disagree with each statement. AGREE DISAGREE 1. There is no secret research on BW in the U.S.. 2. Secrecy may increase the potential Lo for violations of the 1972 BW Convention. 3. Secrecy may increase the potential for violations of the 1972 BW Convention ae ie _— in other countries but not ‘the U.S.. 4. Secrecy is probably perceived by the Soviets as necessary for national security. 2. Secrecy is not necessary for U.S. national security. 6. Secrecy is necessary only for offensive, not a defensive research. 7. The U.S.S.R. will not comply with plans for increased exchanges of information WkiTAWVt- fo on BW. 8. The U.S. Department of Defense does — not sponsor any secret BW research. 9. In the U.S., it is the right of microbiologists to conduct secret research | — if they so choose. (EW dp deSiow ef (au, MI@. It is reasonable to expect microbiologists to "avoid" secret research, but not realistic. li. Secrecy in defensive BW work is not justified. — 2. Secrecy excludes the opportunity for critical _— scientific review by the scientific community. 13. High quality peer review is still possible —— within secrecy restrictions. Comments about this page: Secret fs cEFEengy VE Re nema II. Secrecy (Part 2) Your response and the responses of the panel (N = 19) in the first round questionnaire are indicated after each of the following questions. Please indicate how you would answer the same questions in light of the previous page and the responses of the panel. 1. Do you think the secrecy Surrounding some BW research has a Significantly adverse effect on the quality of the research? PANELISTS RESPONSES: Yes: 7 No: ll Not Answered: 1 YOUR ROUND 1 RESPONSE: Yes Yes No Not Answered YOUR ROUND 2 RESPONSE: Yes No 2. Do you think secrecy increases the potential for violations of the 1972 BW Convention? PANELISTS RESPONSES: Yes: 11 No: 7 Not Answered: 1 YOUR ROUND 1 RESPONSE: Yes Ne No Not Answered YOUR ROUND 2 RESPONSE: Yes = No 3. Do you think secrecy in BW research is necessary for national security? PANELISTS RESPONSES: . Yes: 9 No: 2 Not Answered: 8 YOUR ROUND 1 RESPONSE: Yes No . Not Answered xX YOUR ROUND 2 RESPONSE: Yes No 4. The 1986 Review of the BW Convention resulted in agreements for 1) sharing of BW information, 2) scientist exchange programs and publication of BW research. Do you think that these measures fii signi icantly decrease secrecy in BW research? PANELISTS RESPONSES: Yes: 4 No:13 Not Answered: 2 YOUR ROUND 1 RESPONSE: Yes No Not Answered xX YOUR ROUND 2 RESPONSE: Yes — No IE tred rg! 5. Do you think it is reasonable to expect microbiologists to "avoid" secret research? Please cite the main reason for your answer. PANELISTS RESPONSES: Yes: 3 No: 6 Not AnSwered: 19 YOUR ROUND 1 RESPONSE: Yes No Not Answered Xx YOUR ROUND 2 RESPONSE: Yes No Comments about this page: III. BW Research The following key elements were suggested by the panel in the round 1 questionnaire to DISTINGUISH offensive BW research from defensive BW research. The elements listed here may or may not be measurable. Please indicate (by placing an "x" in the space provided) if you believe the element is effective or not effective for distinguishing offensive from defensive BW research, and if you believe the element is measurable or not measurable. INSTRUCTIONS: CHOOSE ONE: (E) - Effective for distinguishing offensive from defensive BW research Not effective for distinguishing offensive ° from defensive BW research 5 sn 2 — CHOOSE ONE: (M) Measurable (can be observed externally) (NM) - Not measurable (NE) CHOOSE ONE CHOOSE ONE KEY ELEMENTS E NE M NM wit. 1. Research design criteria “ a 2. Extremes of research aA a 3. Purpose in the mind of researcher “ — 4. Observation that BW agents wy have been made into weapons (ie. ty Placed into delivery systems) | SB. Evidence that research is to protect ~ against BW -]6. Evidence that research is to i - Z produce vaccines 7. Quantity of BW agents —“ — 8. Form of BW agents It a — 9. Evidence that research {is to increase virulence and length of — — survival of organisms 18. Evidence that research is designed uo to increase infectivity li. The degree of secrecy involved uw — i2. A committee using hindsight to determine the purpose of the research 13. A neutral third party to make a ( judgment to distinguish Ua $ > offensive from defensive BW Peed research A 14. An evaluation of the purpose a of the research, after an incident | . of BW use ” PLEASE WRITE ANY ..COMMENTS ON THE BACK OF THIS PAGE. IV. Prophylactic, Protective and Peaceful Purposes (Part 1) The following examples of Prophylactic, Protective and Peaceful the space CLEARLY A CLEAR Purposes were generated from the round 1 questionnaire. In provided, Please indicate if you believe the example represents a prophylactic, protective or peaceful purpose. example would be a purpose that could not be construed Prophylactic, non-protective or non-peaceful. as non- CLEAR EXAMPLE OF A PROPHYLACTIC, PROTECTIVE OR PEACEFUL PURPOSE? NO DO NOT KNOW la. To prevent or study a disease. Pa. Epidemiologic or immunologic research. a. Any defensive measure except retaliation. fa. Study of organisms that occur naturally. NA dN 8 a. Working with organisms for the purpose of education Research or development on: nN. Rapid detection systems Dp. Vaccines - Drugs 4. dvreatment mh. Protective devices ysical protection Antibiotics Serum monoclonal antibodies _ Counter agents ( on Cannon Shelters and decontamination methods fl. Detection and microbial identification systems #2. Blocking the entry of released organisms into target population Fe InduStrial applications 4. Food Production nS. Assay systems 6. Impeding an organisms spread 7. Immunoaugmentative Immunomodulation .- Defensive measures > 9. Nitrogen fixers for plants 8. Improving the health of a population \ VINA SY, \ NE SAIN NINN se, PLEASE WRITE ANY COMMENTS ON THE BACK OF THIS PAGE. IV. Prophylactic, Protective and Peaceful Purposes (Part 2) Your response and the responses of the panel (N = 19) in the first round questionnaire are indicated after the following question. Please indicate how you would answer this same question in light of the previous page and the responses of the panel. Do you believe that clarifying the concepts of “prophylactic, protective and peaceful purposes" would weaken or strengthen’ the perceived strength of the 1972 BW Convention. PANELISTS RESPONSES: Strengthen: 9 Weaken: 1 Neither: 5 Not Answered: 4 YOUR ROUND 1 RESPONSE: Not Ansucred YOUR ROUND 2 RESPONSE (Please check one): Strengthen Weaken Neither Comments about this page: - The tone ten jo ca 0) ot houges V. BW and Recombinant DNA Technology (Part 1) Your response and the responses of the panel (N = 19) in the first round questionnaire are indicated after each of the following questions. Several comments made by panelists regarding each question are listed. Please indicate how you would answer the same questions in light of these comments and the responses of the panel. The following comments are based on responses of panelists. ~Existing organisms are sufficient. -Recombinant DNA technology will increase the chance of BW being used in the future, especially if the engineered agent will weaken the enemy and not kill. ~The inability to guarantee the safety of one's own personnel has been a disincentive to BW use in the past, therefore the availability of increased defenses against BW, provided by recombinant DNA technology, will increase the chance of BW being used in the future. -It is not necessarily a disadvantage that genetically engineered organisms do not survive well in the environment. PLEASE RECONSIDER THE FOLLOWING QUESTIONS AND INDICATE YOUR SECOND ROUND RESPONSE IN THE SPACE PROVIDED. 1. Do you think that the capability of designing organisms to the specifications of military planners will increase the chance of BW being used in the future? PANELISTS RESPONSES: Yes: 10 No:6 Not Answered: 1 Do Not Know: 2 YOUR ROUND 1 RESPONSE s YOUR ROUND 2 RESPONSET S35 No Do Not Know 2. Do you think that the availability of increased defenses against BW, provided by recombinant DNA technology, will increase the chance of BW being used in the future? PANELISTS RESPONSES: Yes: 6 No: 1@ Not Answered: 1 Do Not Know: 2 YOUR ROUND 1 RESPONSE 0 YOUR ROUND 2 RESPONSE: Yes No a Do Not Know 3. Do you think BW agents produced by recombinant DNA technology offer any significant advantage over conventional agents in a conflict situation? PANELISTS RESPONSES: Yes: 9 No: 6 Not AnSwered: 1 Do Not Know: 3 YOUR ROUND 1 RESPONSE No YOUR ROUND 2 RESPONSE: Yes “No “ Do Not Know (Codey) V. Recombinant DNA Technology (Part 2) 4a. Do you think that genetically altered organisms survive well in the environment? PANELISTS RESPONSES: Yes: 1 No: 18 Not Answered: 2 Do Not Know: 6 YOUR ROUND 1 RESPONSE ° YOUR ROUND 2 RESPONSE: Yes No ~ Do Not Know 4b. If you answered “no" in 4a. above, do you think this trait can be easily "overcome" by genetic selection? (N = 18) PANELISTS RESPONSES: Yes: 4 No: 6 Not Answered: 4 Do Not Know: 4 YOUR ROUND 1 RESPONSE Yes YOUR ROUND 2 RESPONSE: Yes vw No Do Not Know ow awe a ee ee ee ee ee ee eee ee we ee ww ewe Se Se we Sw we ee we oe ew ew wee ADDITIONAL COMMENTS OR QUESTIONS