STATEMENT OF WORK TO NATIONAL ACADEMY OF SCIENCES FOR RUSSIAN INSTITUTES COLLABORATIVE RESEARCH PROJECT 1.0 SCOPE The Cooperative Threat Reduction (CTR) Program is working with the Russian Federation to expedite the dismantlement and destruction of weapons of mass destruction, to encourage non- proliferation, and promote conversion of military capabilities to peaceful, civilian applications. These efforts will support the CTR program by developing a cooperative support and research program to assist in the conversion of former Soviet Union (FSU) biological weapons (BW) personne! and facilities by redirecting work to public health and other peaceful civilian activities, and by undertaking initial steps toward longer-range cooperative, peaceful, civilian research programs. The program will be executed by the National Academy of Sciences (NAS). The NAS, the National Academy of Engineering (NAE), the Institute of Medicine (IOM) and the National Research Council will collaborate on this project. 1.1 BACKGROUND In the Conference Report on the FY94 Department of Defense Appropriation Bill, Congress stipulated “the National Academy of Sciences has access to technical and linguistic expertise in the U.S. that has already developed extensive contacts within the technological infrastructure in the countries of the former Soviet Union.” Therefore Congress directed that funding “..be reserved for the National Academy of Sciences...” to support the CTR Program. These efforts are to be unilateral on the part of the U.S. However, cooperation from the Commonwealth of Independent States (CIS) is required and actively sought, but formal agreements neither exist nor are planned. The NAS currently has over.100 ongoing contracts with branches _ of the DoD; including DSWA, and thus there is a considerable mutual working experience among the organizations involved. This effort is 2 follow-on to DSWA Contract DSWA001-94-C-0182, Support to the Cooperative Threat Reduction program. The NAS, through its operating arm, the National Research Council (NRC), utilizes the services of volunteer scientists, engineers, and other professionals in its committee system to carry out all of its activities. 1.2 OBJECTIVES The basic objective of this effort is to support the conversion of former Soviet Biological Weapons (BW) research personnel to work on international public health issues. The specific objective is to engage Russian BW researchers in continuing collaborative projects with the West as part of the global effort for research, surveillance, and monitoring of new emerging and re-emerging diseases. Examples of some existing diseases that might be subjects for cooperative work include hantavirus and broader classes of hemorrhagic fevers; tick-borne encephalitis; malaria; tuberculosis; and HIV/AIDS. The specific kinds of research involved could include work on: 1) surveillance and monitoring methods; 2) studies of pathogenesis, transmission and prevention; 3) diagnostic tests; 4) treatments; and 5) new vaccines. DSWA01-96—C-0163 Attachment Ho. 1 Page 1 of 4 2.0 APPLICABLE DOCUMENTS 2.1 House Resolution (HR) 3807 (Title I), Public Law (PL) 102-229 (Section 108). 2.2 . Agreement between the United States of America and the Russian Federation concerning the Safe and Secure Transport, Storage and Destruction of Weapons and Prevention of Weapon: Proliferation, June 17, 1992. 2.3 Reorientation of the Research Capability of the Former Soviet Union: A Report to the Assistant to the President for Science and Technology: Results of a Workshop on March 3, 1992 Sponsored by the NAS, NAE, and IOM, Washington, DC: National Academy Press, 1992. 2.4 Emerging Infections: Microbial Threats to Health in the United States. Washington, DC: National Academy Press, 1992. 2.5 Malaria: Obstacles and Opportunities. Washington, DC: National Academy Press, 1991. 2.6 FAR 6.302-5 3.0 REQUIREMENTS (TASKS) The contractor shall, as an independent contractor and not as an agent of the United States Government (USG) or the Government of Russia (GOR), provide the necessary personnel, equipment and materials to accomplish the requirements specified. 3.1 Task 1: Design of a Detailed Comprehensive Plan for a Cooperative Research Program (a) NAS shall, with the assistance of an expert committee, develop an interim and final detailed and comprehensive plans (CDRL 8 and 9) for cooperative assistance for the conversion of former Soviet/ Russian BW personnel and facilities to work on public health problems of an international nature or within Russia. The plan will detail how the NAS expert committee expects the Russian scientists representing former BW facilities will assist with the project design and initial implementation. The pian will include a list of potential research topics/projects, a list of potential Russian/Wester collaborators. The plan will have a milestones chart which includes all the tasks and all of the efforts necessary to achieve the primary objective. In an effort to promote communication and an exchange of ideas between the Department of Defense (DoD) and the National Academy of Sciences, (NAS), the NAS will present each deliverable listed in Paragraph 5.0 (Deliverables) orally and in printed form at a meeting between NAS and DoD representatives. (b) The contractor shall make and administer all travel and lodging arrangements without . assistance from the United States Government (USG); however, the contractor must notify DSWA of all proposed travel into the FSU. DSWAN1-96-C~0163 Attachment, No. 1 Page 2 of 4 3.2 TASK 2: OtherP