THE WALTER AND ELIZA HALL INSTITUTE oF MEDICAL RESEARCH The Hoyal Melbeurne Parkville. W.2, Vic, Aust. 16th June, 1952 Dr. G. A. Brandly Department of Veterinary Science The University of Wisconsin Madison 6. U.S.A. Dear Dr. Brandly: It is reasonably certain that I shall be in America this fall and I wondered whether I could spend two or three days at Madison. I was extremely sorry I could not accept your invitation in Jamary, and I should very much appreciate a renewal of it for October. I hope very much that my wife will be with me and our present Plans are to be in San Francisco till October 11th and to arrive at Cleveland on Sunday 19th. If we could spend most of the intervening time at Madison it would suit ua very well, I should of course be élad to speak on any aspects of our work here that would be of interest. Would you please convey my regards to Dr. Fred and Dr, Lederberg. Yours sincerely, F. M. Burnet Direetor Information and suggestions pertaining to Dr. F. M. Burnet's tenure at the Gollege of Agriculture as Knapp Visiting Professor during first semester 1952-53, ime of arrival ~ October 13, 1952. Schedule of stay - October 13-19; November 3-30. Salary arrangement - Prorated for 5/17 of semester. Accommodationg ~ The housing bureau has tentatively requested, pending word from Dr. Burnet, a small or medium apartment at the Cleridge Hotel for the week of October 12, The rates are $45/wk. with maid service, $35 without. A room at the Union would be available for the week in October and the 4 in November except for the night of November 8, (Daily rates - $7.50 for double, $3.00 for twin beds), A suite at the Union could be reserved - the rate, $11.50/day. A suite at the Edgewater, perhaps better, would rent at about the same - $300-$540 per month, (Perhaps President Fred should be consulted re housing arrangements). Enapp Professgorghip Duties (1) ¥o teach a course in the field of the professor's special competence for College students, (2) To participate in seminar and conferences with advanced students and staff, (3) fo give two or three public lectures. Proposals for the lectures, courses, conferences, etc. (1) Dean Froker has suggested that the Departments of Veterinary Science and Plant Pathology sponsor arrangemente for and offering of courses mutually acceptable to interested departments and Dr. Burnet. Other proposals are undoubtedly anticipated. (2) Dr. Burnet has suggested in his letter of July 28 that he would like to offer a series of lectures on "The Biology of Infectious Diseases", This approach, he observes, would be similar to that taken in the 1943 Dunham Lectures on evolutionary and ecological aspects of some human virus diseases which lecturg were published as the classical "Virus as Organism", Yet, it would seem that the perspective employed in his 1940 book "Biological Aspects of Infeetious Disease" might be less advanced and more attractive to a larger nunber of our students since it was Burnet's attempt "to discuss his ow field of interest from the point of view of a biologist rather than a medical man", Several have suggested the desirability of offering a special 5 weeks, 1 credit, 100 series course "The Biology of Infectious Disease". pdscussions of infec- tious disease, generally and specifically ae it affects human welfare; the properties, implications and nature of infectious disease from the biological viewpoint and; the evolutionary and ecological aspects of various infectious diseases. 1-3 lectures per week for the five weeks — 420 P.M, MWR. in 205 Babcock Hall, Wouldn't this require special action by curriculum committee? A number of students have expressed their great interest in credit from such a course by Burnet; this perhaps wouldn't exclude others but they should have officiel auditing permits. One or two public lectures could be requested and arranged preferably during the 3rd and 5th weeke of Dr, Burnet's stay when word of his competence and fame has spread, Dr. Burnet would undoubtedly be interested in seminar and conferences partici- pation not only among the more interested departments in the College, but certainly also in the Medical School and some other departments and colleges, Bacteriology and Veterinary Science departments are offering a new in course in "Episootiology" /the fall semester. Dr. Burnet could help materially in its orientation, Publicity The college and university journalism departments, the News Service, etc., should be provided with adequate material. Individuals from considerable distances have already indicated they would like to arrange to come here for some of Burnet's lectures, Dr. Burnet will be invited to lecture elsewhere and will need some respite other than week-ends, BIBLIOGRAPHY F. MM Burnet Burnet, F. M., 1925. The nature of the acquired resistance to bacterlophage action. J. Path. a. Bacter. 28, 407. 1925. Bull. Inst. Pasteur 23, 888. 1926. Zbl. ges. Hyg. il, TC. , 1927. The relationships between heat-stable agglutinogens and sensitivity to bacteriophage in the Salmonella group. Brit. J. exp. Pathol. 8, 121. (1927. Zbl. f. Bakt. |. Ref. 87, 457) » 1932. Lysogenicity as a normal function of certain Salmonella strains. J. of Path. 35, 85!. (1934. Zbl. f. Bakt. I. Ref. 12, th) » 1933. Immunological studies with phage-coated bacterfa. Brit. J. exp. Path. 1h, 93. (1933. Zoi. f. Bakt. i. Ref. ttt, 234) » 1933. A specific soluble substance from bacterlophages. Brit. J. exp. Path. th, 100. (1933. Zbl. f. Bakt. I. Ref. INI, 234) » 1934. The phage-Inactivating agent of bacterial extracts. J. Path. 38, 285. (193k. Bull. Inst. Pasteur 32, 1070. ) 1955. Zbl. f. Bakt. 1. Ref. 116, 7. 1934. The bacter lophages. Biol. Rev. Camb. philos. Soc. 9, 332. (1934. 2b}. ges Hyg. 2, 6 8) Burnet, F. M. and D. Lush, 1936. Induced lysogenicity and mutation of bacterlo- phage within lysogenic bacterla. Aust. J. exp. Blol. med. Sci. 4, 27. (1936. Bull. Inst. Pasteur 34, 988) Burnet, Fe. Me, 1942. Discontinuous variation in influenza virus. Aust. J. Sel. 5, 81. Burnet, F. M., and J. D. Stone, 1945. Further studies on the 0-D phase In influenza A virus. Aust. J. Exp. Biol. med. 23, 15]. Beveridge, W.1.B., and F. M. Burnet, 1946. The Cultivation of Viruses and Rickettsiae In the Chick Embryo. Med. Research Council! Specia! Report Series No. 256. (Reprinted 195%) HMSO, London. Burnet, F. Me, J. Fe. McCrea, and J. 0. Stone, 1946. Modification of human red cells by virus actlon. 1. Receptor gradient for virus action In human red cells. Brit. J. exp. Path. 27, 228. Burnet, F. My, 1947. The receptor-destroying enzyme of V. cholerae. Aust. J. exp. Biol. Med. 25, 227. =D - Burnet, F. Me, Je F. McCrea, and S. 6. Anderson, 1947. MuciIn as substrate of enzyme action by viruses of the Mumps-influenza group. Nature. 160, 4ob. Burnet, F. My 1948. Variation In Influenza viruses. Handbuch d. Virusforschung. » 1951. A genetic approach to variation In Influenza viruses. 4. The erecters of three substrains of Influenza virus A(WS), J. Gen Microbiol. De 46. » 1951. A genetic approach to variation In Influenza viruees. Il. Variation in the strain NWS on allantotc passage. J. Gen Microbiol. 5, 5h. » 1951. A genetic approach to variation [n Influenza viruses. 11. Recom- bination of characters In Influenza virus Strains used tn mixed Infections. J. Gen. Microblol. 5, 39. » 1951. Mucoproteins In relation to virus action. Physiol. Rev. 31, 13}. » 1951. Some biological imp! ications of studies on Influenza viruses. Bull. Johns Hopkins Hosp. 88, 119. Burnet, F. M., and P.-E. Lind, 1951. A genetic approach to variation In influenza viruses. IV. Recombination of characters between the Influenza virus A strain NWS and strains of different serological subtypes. J. Gen Microblol. Dy OTs » 1953. Influenza virus recombination: Experiments using the De-embryonated egg technique. Cold Spring Harbor Symp. Quant. Bio!. 18, 2l. » 1953. Recombination of Influenza viruses in the De-embryonated egg. i. The use of periodate-treated sera for in vitro characterization of Influenza virus strains. Aust. J. exp. Blol. Med. 32, 145. » 1954. Recombination of Influenza viruses in the De-embryonated egg. 11. The conditions for recombination and the evidence for the possible existence of diplold Influenza virus. Aust. J. exp. Blol. Med. 32, 153. » 1954. Reactivation of heat Inactivated Influenza virus by recombinatlon. Aust. J. exp. Blol. Med. %2, 133. » 1954, The genetics of virulence In influenza viruses, Nature 173, 627. Burnet, F. Me, 1957. A modification of Jern's theory of antibody production using the concept of clonal selection. Aust. J. of Science 20, 67. Lind, ?. €., and F. M. Burnet, 1957. RecombInatlon between virulent and non- virulent strains of Influenza virus. 1. The significance of heterozygosis. Aust. J. exp. Biol. Med. 35, 57. » 1957. Recombination between virulent and non-virulent strains of Influenza virus. #1. The behaviour of virulence markers on recombination. Aust. J. exp» Blol. Med. 35, 67. BOOKS Burnet, F. M. and F. Fenner, 1949. Production of Antibodies. (2nd. Edition Macmillan, Melbourne. ) Burnet, F. M., 1945. Virus As Organism: Evolutionary and Ecological Aspects of Some Human Virus Diseases. Harvard University Press, Cambridge, Mass. » 1953. Natural History of Infectious Disease. (2nd. Edition) Cambridge University Press, Cambridge. » 1955. Principles of Animal Virology. Academic Press Inc., New York.