SUMEX

STANFORD UNIVERSITY
AEDICAL EXPERIMENTAL COMPUTER RESOURCE
RR-00785

ANNUAL REPORT—YEAR 15

Submitted to

JIMEDICAL RESEARCH TECHNOLOGY PROGRAM
NATIONAL INSTITUTES OF HEALTH

June 1, 1988

STANFORD UNIVERSITY SCHOOL OF MEDICINE
Edward H. Shortliffe, Principal Investigator
Edward A. Feigenbaum, Co-Principal Investigator
DEPARTMENT OF HEALTH AND HUMAN SERVICES
PUBLIC HEALTH SERVICE
NATIONAL INSTITUTES OF HEALTH

DIVISION OF RESEARCH RESOURCES |
BIOMEDICAL RESEARCH TECHNOLOGY PROGRAM

ANNUAL PROGRESS REPORT
PART 1., TITLE PAGE

. PHS GRANT NUMBER: 5 P41 RROO785-15

. TITLE OF GRANT: SUMEX

Stanford University Medical
Experimental Computer Resource

. NAME OF RECIPIENT INSTITUTION: Stanford University

. HEALTH PROFESSIONAL SCHOOL: School of Medicine

. REPORTING PERIOD:

Sa. FROM: 08-01-87
Sb. TO: 07-31-88

. PRINCIPAL INVESTIGATOR:

6a. NAME: Edward H. Shortliffe, M.D., Ph.D.
6b. TITLE: Associate Professor of Medicine
and Computer Science

6c. SIGNATURE:

. DATE SIGNED: July S , IV &F

. TELEPHONE: 415-725-3387
5P41-RROO785-15

Table of Contents

I. Tithe Page
ll. Description of Program Activities

ILA. Scientific Subprojects
i.B. Books, Papers, and Abstracts
IC. Resource Summary Table

Ili. Narrative Description

II.A.

11.B.

IN.C.
li.D.

ILE.
INF.

Summary of Research Progress
LA.1. Resource Overview
HlA.1.1. SUMEX-AIM as a Resource
H.A.1.2. Significance and Impact in Biomedicine
lil.A.1.3. Summary of Current Resource Goals
l.A.2. Details of Technical Progress
ill.A.2.1. Progress Highlights
1l.A.2.2. Core ONCOCIN Research
1.A.2.3. Core Al Research
Il.A.2.4. Core System Development
I.A.2.5. Relevant Core Research Publications
Il.A.2.6. Resource Equipment
.A.2.7. Training Activities
iil.A.2.8. Resource Operations and Usage
Highlights
ill.B.1. PROTEGE -- Developing Knowledge Acquisition Tools for
Clinical Trial Advice Systems
ll.B.2. A Speech Interface to ONCOCIN
HI.B.3. SIMPLE/CARE -- Emulation of Parallel Computing Architectures
lI.B.4. Toward the Distributed SUMEX-AIM Community
Administrative Changes
Resource Management and Allocation
Ill.D.1. Overall Management Plan
Ill.D.2. 2060 Cost Center
Dissemination of Resource information
Suggestions and Comments

IV. Description of Scientific Subprojects

IV.A,

iV.B.

Stanford Projects

IV.A.1. BBICU Project

IV.A.2. GUIDON/NEOMYCIN Project
IV.A.3. MOLGEN Project

IV.A.4. ONCOGCIN Project

IV.A.5. PROTEAN Project

IV.A.6. RADIX and PENGUIN Projects
National AIM Projects

oaananownw o =

E. H. Shortliffe
5P41-RROO785-15

IV.B.1. ATTENDING Project 182

1V.B.2. INTERNIST-1/QMR Project 186

IV.B.3. MENTOR Project 197

IV.C. Pilot Stanford Projects 196
1V.C.1. REFEREE Project 197

IV.D. Pilot AIM Projects 203
IV.D.1. Dynamic Systems Project 204

IV.D.2. Pathfinder Project 211

IV.D.3. Knowledge Engineering for Radiation Therapy 217

IV.E. AIM Communications Users 220
Appendix A. Knowledge Systems Laboratory Brochure 225
Appendix B. Lisp Performance Studies 237
Appendix C. Lisp Environment Specification 251
Appendix D. AIM Management Committee Membership 273
Appendix E. Scientific Subproject Abstracts 277
References 301

E. H. Shortliffe ii
5P41-RROO7 85-15

Figure
Figure
Figure
Figure
Figure
Figure
Figure
Figure
Figure
Figure
Figure
Figure
Figure
Figure
Figure
Figure
Figure
Figure
Figure
Figure
Figure
Figure
Figure
Figure

OONOGPwON >

ahhh mh eh ehh hh
OHBNOARWONASD

NNN dD
BON >

29

List of Figures

Core System Development Schedule
Recent ARPANET Coverage Map
SUMEX-AIM DEC 2060 Configuration
SUMEX-AIM SUN-4 Configuration
SUMEX-AIM Sun-3 File Server Configuration
SUMEX-AIM Xerox File Server Configuration
SUMEX-AIM VAX File Server Configuration
SUMEX-AIM Deveicon X.25/TCP-IP Gateway Configuration
SUMEX-AIM Ethernet Configuration
Total CPU Hours Consumed by Month
Monthly CPU Usage by Community
Monthly Terminal Connect Time by Community
Cumulative CPU Usage Histogram by Project and Community
Table of Resource Use by Project
Public Data Network Terminal Connect Time
INTERNET Terminal Connect Time
2060 Downtime Summary -- Hours per Month
Overall 2060 Reliability Summary
2060 Cost Center Performance
Run Times for BB1 and SOAR
Compilation Times for BB1 and SOAR
Run Times for BB1 under Various Compiler Settings
Compilation Times for BB1 under Various Compiler Settings
Differences Between Normal and Reduced Ouput SOAR Run

49
77
90
91
92
93
94
95
96
101
103
104
106
107
112
112
113
113
122
245
246
247
248
249

iii E. H. Shortliffe