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PUBLICATIONS A. = - . Published in Regularly Scheduled Periodicals During Fiscal 1972 Ammerman, A., and L.L. Cavalli-Sforza, "Measuring the Rate of Spread of Early Farming in Europe," MAN, Vol. 6, pp. 674-688, December 1971. Chester, T., P. DeClercq, and T. Merigan, "PolyrI, PolyrC and Antibody, Interferon, and Phagcytosis," INFECTION AND IMMUNITY, April 1971. Glaze, H.J., Jr., and E. Dong, "Vagal Control of Heart Rate," in Abstracts of the American Heart Association, 44th Scientific Sessions, Supplement II to CIRCULATION, Vol. XLIV, October 1971. Glick, D., K. Marich, J. Orenberg, P. Carr, and D. Miller, "Effect of Atmosphere on Spectral Emission from Plasmas Generated by the Laser Microprobe," ANALYTICAL CHEMISTRY, Vol. 43, pp. 1452-1456, September 1971. Ingels, N.B., Jr., G.T. Daughters, II, S.R. Davies, and I.B. MacDonald, "Stereo Photogrammetric Studies on the Dynamic Geometry of the Canine Left Ventricular Epicardium," J. BIOMECHANICS, Vol. 4, pp. 541-550, 1971. Kaplan, B.E., J.C. Corby, and P.H. Leiderman, "Attention and Verbalization: Differential Responsivity of Cardiovascular and Electrodermal Systems," JOURNAL OF PSYCHOSOMATIC RESEARCH, Vol. 15, pp. 323-328, 1971. Levine, R. and N. Kretchmer, "Conversion of Carbamyl Phosphate to Hydroxyurea: An Assay for Carbamyl Phosphate Synthetase," ANALYTICAL BIOCHEMISTRY, Vol. 42, No. 2, pp. 324-337, August 1971. Levine, R., N. Hoogenroad, and N. Kretchmer, “Copurification of Carbamoy] Phosphate Synthetase and Aspartate Transcarbamoylase from Mouse Spleen, " BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol. 44, pp. 981-988, 1971. Levine, R., N. Hoogenroad, and N. Kretchmer, “Regulation of Activity of Carbamoy] Phosphate Synthetase from Mouse Spleen," BIOCHEMISTRY, Vol. 10, No. 20, pp. 3694-3699, 1971. Melges, F.T., R.E. Anderson, H.C. Kraemer, J.R. Tinklenberg, and A.E. Weisz, "The Personal Future and Self-Esteem," ARCHIVES OF GENERAL PSYCHIATRY, Vol. 25, pp. 494-497, December 1971. Morris, S., H. Ralston, and . Shooter, "Studies on the Turnover of Mouse Brain Synaptosomal Proteins," J. NEUROCHEM., Vol. 18, pp. 2279-2290, 1971. Nola, G., et al., "Action of Acetystrophanthidin on Experimental Myocardial Infarction," AMER. J. PHYSIOL., Vol. 222, pp. 265-71, February 1972. Pauling, L., A.R. Robinson, R. Teranishi, and P. Cary, "Quantitative Analysis of Urine Vapor and Breath by Gas - Liquid Partition Chromatography," PROC. NAT. ACAD. SCI. USA, Vol. 68, No. 10, pp. 2374-2376, October 1971. (112) Silbergeld, S., N. Brast, and E. Noble, “The Menstrual Cycle: A Double-Blind Study of Symptoms, Mood, and Behavior, and Biochemical Variables Using Enovid and Placebo," PSYCHOSOMATIC MEDICINE, Vol. 33, p. 411, 1971. Swanson, G., T. Carpenter, D. Snider, and J. Bellville, "An On-Line Hybrid Computing System for Dynamic Respiratory Response Studies", COMPUTERS AND BIOMEDICAL RESEARCH, Vol. 4, pp. 205-215, April 1971. Teranishi, R., T.R. Mon, A.B. Robinson, P. Cary, and L. Pauling, “Gas Chromatography of Volatiles from Breath and Urine," ANALYTICAL CHEMISTRY, Vol. 44, p. 18, January, 1972. Thoman, E., C. Barnett, and P. Leiderman, "Feeding Behaviors of Newborn Infants as a Function of Parity of the Mother," CHILD DEVELOPMENT, Vol. 42, pp. 1471-1483, 1971. Thoman, E., J. Olson, and P. Leiderman, "Neonate-Mother Interaction During Breast-Feeding," DEVELOPMENTAL PSYCHOLOGY, Vol. 6, No. 1, pp. 110-118, 1972. Thoman, E. and A. Korner, "Effects of Vestibular Stimulation on Behavior and Development of Infant Rats," DEVELOPMENTAL PSYCHOLOGY, Vol. 5, No. 1, pp. 92-98, 1971. Watson, W., H.M. Cann, E.M. Farber, and M.L. Nall, "The Genetics of Psoriasis," ARCH. DERM., Vol. 105, pp. 197-207, February 1972. B. Other Publications Ammerman, A., and L.L. Cavalli-Sforza, "A Population Model for the Diffusion of Early Farming in Europe," Proceedings of the Research Seminar in Archaeology and Related Subjects, Sheffield, December 1971. Barth, G., R.E. Linder, E. Bunnenberg, and C. Djerassi, "The Magnetic Circular Dichroism of Porphyrin Dications," presented at the April 3, 1972 Porphyric Conference sponsored by the New York Academy of Sciences, to be published in the ANN. N.Y. ACAD. SCI. (spring 1972). Bernfield, M., "Chromatographic Properties of Pyrrolidone Carboxylate-tRNA," submitted to J. BIOLOGICAL CHEM. (spring 1972). Bernfield, M., "Characterization of Pyrrolidone Carboxylate-RNA from Rat Liver," in preparation (spring 1972). Bodmer, W.F., and L.L. Cavalli-Sforza, "Variation in Fitness and Molecular Evolution," PROCEEDINGS OF THE SIXTH BERKELEY SYMPOSIUM ON MATHEMATICAL STATISTICS AND PROBABILITY, CONFERENCE ON EVOLUTION, April 1971. Bodmer, W.F., and L.L. Cavalli-Sforza, "Migration Matrices," IV INT. CONGR. HUMAN GENETICS PROCEEDINGS, in press (spring 1972) (113) Bodmer, W., and L. Cavalli-Sforza, THE GENETICS OF HUMAN POPULATIONS, Freeman and Company, 1971. Buchanan, B.G., D.H. Smith, R.S. Engelmore, A.M. Duffield, A. Yeo, E.A. Feigenbaum, J. Lederberg, and C. Djerassi, "Applications of Artificial Intelligence for Chemical Inference," submitted to J. AM. CHEM. SOC. (spring 1972). Buchanan, B.G., E.A. Feigenbaum, and J. Lederberg, "A Heuristic Programming Study of Theory Formation in Science," Stanford Artificial Intelligence Project, Memo AIM-145, Computer Science Department Report CS 221, June 1971. Buchanan, B.G., and J. Lederberg, "The Heuristic DENDRAL Program for Explaining Empirical Data," presented at the 1971 Congress of the International Federation of Information Processing Society (August 1971) and published by North Holland Publishing Co. Buchanan, B.G., £.A. Feigenbaum, and J. Lederberg, "Beyond Heuristic DENDRAL," presented at the International Joint Conference on Artificial Intelligence (September 1971) and published in the Proceedings. Calvert, J.L. and J.H. Frenster, "Economics of Effectiveness and Efficiency in Patient Care," CLINICAL RESEARCH, Vol. 19, p. 501, 1971 (abstract). 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Fries, J., “The Effect of Ice Water on Esophageal Rewarming in Connective Tissue Diseases (CTD)," abstract submitted to GASTROENTEROLOGY (spring 1972), Glaze, H.J., Jr., and £. Dong, "Mathematical Analysis of the Impulse Response of the Vagal Nerve - Heart Pacemaker System," in PROCEEDINGS OF THE 24TH ANNUAL CONFERENCE ON ENGINEERING IN MEDICINE AND BIOLOGY, Vol. 13, 1971. Glick, D., "Cytochemical Ane: :..5 by Laser Microprobe - Emission Spectroscopy," RECENT ADVANCES IN QUANTITATIVE HISTO- AND CYTOCHEMISTRY, pp. 192-193, 1971. Gold, J. A., G.S. Harrell, B.R. Bradley, and F.F. Zboralske, "Sequential Esophageal Blood Flow Determination," submitted ta GASTROENTEROLOGY (spring 1972). (115) Gordon, L., "Completely Separating Groups in Subsampling," submitted to ANNALS OF MATH STATIST., (spring 1972). Gordon, L., “Efficiency in Subsampling," submitted to J. AMER. STATIST. ASSN., (spring 1972). 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Staff Technical Notes AAC-1 AAD-1 ACH- 1 ADDA-1 AFORT-1 AG-1 AORG~-1 APAGE-1 APAGEX~- 1 ARATE-~1 BASS-1 BGOLD-1 ACHE User Accounting -- Update & Listing (Bassett, C. Miller) AUG 13, 1971 APUB -- AUG 13, Update & Listing 1971 (PlaschysC. Miller) Summary NOV 30, of Campus/ACME Serger Study (Jastgaard) 1971 Additions to ACME Software Suggested by Users (Jamtgaard) APE 20, 1972 Implementing a Tise-Shared/Realtise Systea in FORTRAN (Frey) APB 23, 1971 Usage of the ACHE System (Wiederhold) To be published in Statistik an Dokusentation in der Medicine, NOV 15, 1971 ACME Organization Chart (Baxter) MAR 6, 1972 ACME Service Rates (Jantgaard) APR 16, 1972 Description of ACHE Service Rates (Jaatgaard) APR 13, 1972 Revised Rate Structure for ACHE Facility Services (Subpitted to NIH) (Jamtgaard) APR 16, 1972 An Assessment of Current Developrents in Coaputer Technology and their Significance for Developrent at the Stanford Medical Center (Wiederhold) MAY 1, 1972 Beyond LISP (Wiederhold) MAR 29, 1972 ACME Program Library PLA_PLi: Converting a PL/ACSE Program into an Equivalent PL/1 Progras (Berman) JUN 16, 1971 Programs for Processing of Temperature Data in SCLERODERMA (J. Gold/Wiederhold) DEC 30, 1971 bSPD-1 CONS-2 CRASH-1 CSMP-1 CSMPI-1 CTP-1 DEC-1 DP-1 DSLL-1 EDQ- 1 EEW-1 nFFT- 1 EG-1 EIRP-1 EOPS- 1 EPP-2 (118) Sharing Patient Data Files (Wiederhold) MAR 29, 1972 Consulting Schedule (Wiederhold) FEB 2, 1972 Recovery from Cisk Failures (Frey) SEP 24, 1971 Design Considerations for a Digital Analog Simulator on ACME (Hjelmeland) OCT 15, 1971 Interactive Continuous System Modelling Program ‘(J. Hu) APR 16, 1972 Communication Port/Terminal Protection (Wiederhold) MAR 6, 1972 Decimal Arithmetic in ACME (Wiederhold) FEB 14, 1972 Proposal for Decimal Arithmetic in ACME (Wiederhold) FEB 14, 1972 315C (Loma Linda) Display Terminals ({Freret) OCT 28, 1971 ACME Program Library DATACOPY: Reproducing a Complete or Partial Data Pile (Wiederhold) NCV 15, 1971 Accuracy of ACME Statistical Subroutines (Whitner) AUG 9, 1971 ACME Subprograms FFT and FFTD: Fast Fourier Transforms (Whitner) MAR 10, 1972 ACME Subprogram GRAPHH: Creates Display and Plotter Output (Hale) MAK 22, 1971 Information Retrieval Program (Radiation Therapy Dept.) (J. Hu) NOV 18, 1971 Versatile Plotting System {Hale) JUN 15, 1971 ACME Subprogram PLOTPRIN: Flots Graphs and Prints on Line Printer or Terminal (J. Hu) FEB 16, 1972 FPKR-2 FRM-1 FSEC-1 FSTAT-1 FUTIL-1 HAC~-1 HBE-1 HBS~1 HEPR-1 HHOG-1 HLP-1 HPWR-1 HSCI-1 HWEA-~1 J33 (119) Restoring Blocks Onto Disk From Tape (Lew) FEB 29, 1972 File Utility Restore and Move Programs (Frey) JAN 12, 1972 File Security (G. Wiederhold) FEB 25, 1971 File System Statistical Summary (J. Hu) AUG 9, 1971 Pile System Utility Library (Frey) JUN 9, 1971 Log@a Linda Terminal/ACME 1800 Link (Matheson) BUNO57 OCT 11, 1971 Beehive CRT Display Terminal to PDP-11 Interface (Stubbs) JAN 3, 1972 Bioscience/ACME 1800 Digital-Analog Link (M. Hu) EUNO46 SEP 1, 1971 Varian EPR Recorder to IBM 1800 Interface (M. Hu/Matheson) JUL 20, 1971 Cable Voltage Levels for the Sanders (Cower) JUL 9, 1971 Litton Printer to PDP-11 Interface (Stubbs) JAN 3, 1972 A Proposed Method of Protecting Computing Machinery from Power Surges (Hundley) JAN 31, 1972 Scan Converter Interface (Stukbs) JUN 18, 1971 Summary of Western Electric (Telephone Cospany) Analog Modems (Stainton) JAN 17, 1972 User Note: ACME Keywords,Conversion Progras PLA_PL1,Truth Tests in ACME, Computer Room Modifications (Staff) MAY 25, 1971 J34 J35 J36 J37 J38 J39 J4&0 J4i KBEE-1 (120) User Note: Consulting Schedule,Progragr JOBTAKER PUBLIC,Graphics Package OPS (Staff) JUL 20, 1971 User Note: Special Announcement, Hardware Substitutions, Bulk Core, Disk CDPrives, Small Machine Intertace (Jamtgaard) OCT 22, 1971 User Note: New Bulk Core and Cisks, PLCTPRIN, Loma Linda Graphics, New Commands in PL/ACME (Staff) NOV 5, 1971 User Note: Performance Tests cn New Bulk Core, New Text Editing Features, LATACOEY, EVENT, User Tape Services, New Character String Function, New [Information on LOGOFF (Staff) NOV 18, 1971 User note: Holiday Schedule, Fermitting of Real Time Lines, User Services, Consulting Service Schedule, Clean Up Your Files! (Staff) DEC 21, 1971 User note: Seminar on Time-Oriented Medical Records, Small Machine Multiplexor, Medical Center Computer Facility Planning Committee, Printing and Punching Services, Double Precision Argument Bug, New Show Command: SHOW CSOPEN (Staff) FEB 7, 1972 User note: Revised Operating Hours, Medical Computing Seminars, PL/1 versus PL/ACME Compatibility, Small Machine Multiplexor Interface, System Errors 226 and 237({File System), Program CATALCG PUBLIC, Fast Fourier Transforms, Antilogs (Staff) FEB 28, 1972 User Note: Revised Rates for ACME Service, New Terminal Support (Memorex), Medical Computing Seminars, Reassignment of Gio Wiederhold, New ACME Note Index, New LISTAKER/JOBTAKER Feature, Bug: Character string Variable and Title Cption, Card and Paper recyling, Acknowledging ACME in Puklications (Staff) APR 10, 1972 Using the Beehive Terminals on ACHE (Wiederhold) NOV 30, 1971 KON-1 KPERA~2 KTB-1 KTBA-1 LM-5 PEFF-1 PLC-2 PLCH-1 PPa-1 PPLO-1 Pscs-1 RSY-1 UEI-1 UEVT-1 ULA- 1 (121) Comaunication Development (Wiederhold) JAN 4, 1972 PERAIT18 Function - User Perait on 1800 (Granieri) DEC 13, 1971 Character Translations for Teletype and Beehive Terminals (Wiederhold) FEB 14, 1972 Changes to TTY Translation Takles (Stainton) MAY 17, 1972 Edit Commands (Berman) NOV 18, 1971 Proposal to Aid in More Efficient Usage of Disk (Wiederhold) DEC 30, 1971 Compatibility Requiresents for PL/ACAE Programs to Use IBM‘s PL/1 (Wiederhold,sFrey) MAR 8, 1972 A Choice of Language to Support Medical Research (Wiederhold) Position paper for a panel discussion on "Coaputer Language for Medicine," to be held at the 1972 ACM Conference, Boston MAR 6, 1972 ACME/LISP Internal Documentation (Berns) JOL 14, 1971 Proposal: Interactive Prograass for Pile Bditing and Data Plotting (Weyl) APR 20, 1972 Proposal for Small Computer Service By ACBE (Stainton) MAR 21, 1972 Proposal to Allow Release of Sysbol-Table pages in Production Jobs (Wiederhold) NOV 23, 1971 ACNE Realtize Library Program IRON: Smoothing by TRONing with an Exponential Decreasing Window (Wiederhold) DEC 13, 1971 Realtime EVENT Function (Frey) NOV 4, 1971 ACHE Real Time Program Library AZTEC: Data Reduction for a Sequence of Sasples (Wiederhold) NOV 23, 1971 ULC-1 UPDP- | WCTR-1 WDERM-1 WPDP-1 WPDPA~1 WPDPB-1 WPDPC-1 WSVC-1 XPL-1 YDEBE-1 £u-1 L4PICK-2 é6YL-1 (122) ACME Realtime Library CUADRO: Smoothing Using a Square Window (Wiederhold) FEB 17, 1972 PDP-11 Hanging the 360 Channel (Briggs) MAB 1, 1972 ACME System Core Timing Results (AMPEX vs. 18M) (Frey) NOV 29, 1971 Terminal In and Output for 3270 Displays (Wiederhold) DEC 30, 1971 Disk Monitor for the PDP-11 (triggs) JUN 21, 1971 Index for PDP-11 Software Hinder in the Computer Room (Briggs) AUG 9, 1971 Using the Litton Printer On ACME Through the PDP-11 (Briggs) AUG 13, 1971 bisk Monitor Utility Program for the PDP-11 (Briggs) AUG 16, 1971 ACME Written SVCs (Frey) SEP 1, 1971 Inferred Syntax and Semantics of PL/S (WiederholdyEhrman) OCT 15, 1971 NVTDEBE ~ OS/360 Multi-Purpose Utility (Frey) DEC 7, 1971 Flow Chart for ACME System Program MODIFY (Berman) JAN 10, 1972 PICK Flowchart and Tables (Berman) JAN 10, 1972 Flow of Light Logic in YIELD (Wiederhold) DEC 15, 1971 (123) APPENDIX A Summary of Campus/ACME Merger Study (124) ACME Note ACM] Ron Jamtyaard Summary of Campus/ ACME Merger Study November 30, LOY 1 The study of this potential merger has been limited to five specific areas: - The capacity of the 360/67 to absorb the ACME load; * An overview of services and cost considerations; * A brief statement of the planned changes to the Campus Facility; A list of relative advantages and disadvantages of such a merger; and Comments on cost comparisons. There follows a summary of considerations in these five areas. 300/67 Capacity: In July a test was conducted to determine whether the 360/67 timesharing monitor called ORVYL could handle its current load plus ACME's current load plus the anticipated load associated with the new information retrieval system called SPIRES. The test indicated that the 360/67 had adequate cycles and performance capability to handle the anticipated SPIRES load plus a substantial ACMI; load based on current ACME usage levels. The 360/67 has considerable unused capacity today. The test of ORVYL capacity demonstrated that a considerably heavier load could be handled with acceptable degradation and response times to the user. The test did tax the capability of the system with respect to its paging system on the drums; but this was fully expected. The ACMI portion of the test appeared to consume approximately 79 per cent of the 460/67 eycles. The simulation of the ACME load consisted of a series of WORTRAN routines which would require cycles corresponding to approximately 15 users in execublion on the current ACMM hardware (560/50 with ? megabytes of 8 micro- second bulk core). Overview of Service and Cost ConsideraLtions: The Campus Facility provides the following services: production batch service, quick partition batch service, timesharing in at least three languages, text editing, (one of the best found anywhere), plotting, and remote job entry. Many languages are supported in the preduction batch partition. Rates for use of the system have been designed tc remove administrative fiat with respect to scheduling of resource utilization. Thus, priority can be obtained by any user who is willing to pay a fee. No realtime support services are offered at the present time, although there is limited small machine support through the PDP-9. Card readers are handled by both computer operators and users. Fast printing service is available and normally the turn around time is extremely good (a few minutes). Terminal services are normally offered between 8 a.m. and 1:00 a.m. except. for brief periods of system staff time from 5 to 8 p.m. three days per week, plus some system time on weekends. (125) ACM-1 Page 2 Comments On Planned Changes: The Campus Facility is likely to acquire some new hardware by January 1973. The new hardware could either replace existing systems or could supplement them. For example, a fast batch engine could be acquired to support the current 360/67 services, It is essential that any potential hardware changes in the Campus Facility be capable of demonstrating cost effectiveness. Operations over the past 4 years have led to an approximate $600,000 deficit. It is hoped thet user fees and cost reductions over the next couple of years can remove the deficit. The Campus Facility anticipates having the SPIRES Information Retrieval System operating for users within the next year. This new service will fill a major need. The library automation system BALLOTS developed in the environment pro- vided by SPIRES and ORVYL is being developed and has the University Large Lib- rary Commitment. Some of the planned changes on the 360/67 entail optimizing the systems which are presently run there. A major new service to be offered by the Campus Facility will be an interactive version of a subset of the PL/1 lang- uage. This will be especially interesting to users of the current ACME system. Advantages of Potential Merger: 1) Availability of an increased range of services to the Medical School users, including batch service and additional languages; 2) Participation in the system which the University is committed to support would increase the financial support available for computing. The University Computing Fund used for unsponsored research and student computing has been running approximately $700,000 per year. The Medical School use of such funding has been limited to approximately $15,000 per year, primarily due to the avail- ability of ACME. The University's Computing funds have been declared to be unavailable for use on the ACME system since the primary focus of the University must rest with the support of a central system; 3) Data bases could be easily shared among various disciplines within the University; 4) The new SPIRES Information Retrieval facility would be available to medical users; 5) The service center would not be totally dependent upon one source of funding such as NIH with respect to medical funding. Thus it would be less sen- sitive to use by a single group of users; 6) There may be long term advantages associated with economy of scale with respect to hardware, staffing, and physical plant; 7) The Medical School would not have to assume full financial responsibili- ty for a sizable computing facility such as ACME; the risk would be shared among all schools within the University for a central facility. Disadvantages of the Potential Merger: 1) The realtime services which already exist on the ACME system do not exist on the Campus Facility. ACME is currently attempting to develop a real time support system which would be host-machine independent. Campus Facility may add it as a service, 2) ACME type service has a strong personal relationship quality which may be more difficult to attain in a system shared by several thousand users;