Ww oO r a rd a £ “ISN TRNGTATPUL suo ueyy sow BuTysoddns query » wa 8 a ‘uoTyeTMUTS zeqgndwoo fq sqydaouco Teorqs1yeqs pa Sayre ONS "Hh LE °22 t HIN TISOONNx | UTeaT uwO squEPNas TeoTpaul zeyQeUM oUTWTEQeC quepnys Teotpan ‘a “reueyong 88 BS C26°T S9L* dz 166 "HT h HIN TICOO Mx *SOTASTIBYSOTA UT UOTJONAYSUT Teqndwop quepnys TeoTpen "Md “uMoag "oye ‘sore soejams “4UuSTam Apog ‘oe uZTM syuese Tog’ eT9 "Hh 2g6°1 t HIN TICOOMM oTyNaderayy JO FTeAsT ues BuTZwTe1109 quepnis Teotpay “Nd “uMozg S6l"2 gog "0 0gs"o t HIN TTC OOUNx *sueqsfs Atosues uy Buypsseooad uot yeumogul quepngs TeoTpew ‘a ‘fpoag "SesouseIpP TeTqQUE 662°0 $69 °S LTL‘T q HIN TTEOONd* -JOFFTP FO UoTZeTMMAoZ pue Sutye, A1L04sTH ZUePNyS Teotpen *g ‘Kporg *“TTnWTAs T9T"O OTO'O 200°O t HIN TTEOOUMx oTysnose of sasuodsez Aemyyed AzoyTpny quepnys Teotpen Y qqTag "eyep Tequswtaadxea uo sorys(qeqs d1t2 HOL*OT Sat tt HIN TTE00Ux TeTquezesUy pue eaTqdtazosop Supzetnoley quepnys Teotpew “N Qseag yooTq aad | aqnuywated sad - soe . ‘ sue. OL’ Ww quea T* 48 q (aaua) 4 AtoBeyep JTooyos Teotpey ‘uoTgzonpA quepnyzs HLS 2gh °2oT 650° OH TWLOL-dns spung WOTTEPIMOT yoTRasay 962°0 £69 °S SRO € uot yepune,s Teorpan oly oTed ‘a 34us0 OT’ 7 squeo 2° ye c (TWHOL) € Sr08878D -~ TyoTpeW “pzozueys-toN (M)ezez04g YOOTE (W)saqnutwaseg (SUTU 4) SOqnUtW Azos | *quy Tenuuy fouady TSQuMN AWG how rodd NOTEOLILGNI MOLVOLLSZANT gsseooy TeUTUZay, ~ayeg quaadaing uoTzyeOTITYUSPT INANLYVdsa LNAWd LOA YA LAdWOO Aas GYOddNS LOVHINOD HO LNVYD LOFT TL/9T/h - OL/LU/ pataacg potsed SLOTPONd YASH TVNCLATCNE HOVSN dOMNOSAY WALNINOD FO AYWWWNS (101) a - "ISSN TENGTATpUL ouo UWeyy azou Buy4yaoddns query » 2 cH ae ‘owkzus STU} JO msTUelDaM ToO“quoo om Aol Yorves faseqayyuks aqeydsoud TAoweqzreo = 6 Sees TST 20T OF 0" Le t HIN TISOOWN aug FO soTJaUTY paqeoltduos ayy uo satTpnyg quepnys TeoTpaw ‘a foupseT Br ae HO (szesy a ‘aRerO4s aT lg STOOUB TT 898 TH) 0S0°0 gee" ooTa 106° O16 % HIN LTSOOUN Ou fseoTAdes ZoqeTNoOTeo ysep yuapnys couTW FUSPNIS TeOtpew “"N'n “umouy “squowtaadxe 699°T LLG°EHT 225 °Qh t HIN TTSOOUNy ALOyeLogeT woLy ByYBY UO sqsoq TeoTISTIBIS quapnys TeoTpay “mM fuep *sadoyos 1 966 “tT ¢eo"Th 066° 2T t HIN LIGOONHe | PATPOBOTPBA YQTA MOTT POOTG JeaTT Burqyunreag qUeEPN4yS Teotpen "A “UOSNTTOH “quawuoiTaua ateayy jo sTesterdde CTT "2 TLB°S 206°¢ q HIN TISOOWdx | IT8u3 pue suOTyOWs UeUMY UsaMqeq UOTABTeLAOg quepnyis TeoTpan "y STarey ‘saseugudory -OeTS [ee WOT UOTYSULIOJUT JO TeaaTayed oT BLU 2TH HT cole t HIN TTEOOUNx | -Bueqscs pue “uoTzBOTZTJUeNb ‘uoTywyerdrta4quT quepnys Teotpen ‘ad “uyeH *STBALOQUT aouEpTjuUOS yo AouaToT ye BSutupumexs a0 9TO"G 2€9°2T GLG°E q HIN TICOOUNx SeTd@TIeA WOpueA JO uoTYeLeued oTIe) aquoW quepnys Teorpent “YT ‘ops0y “yoreased TeoTSoTotsxudoaqyoata €og"o 22g" 2h OFC 7 HIN TTCOOMNH UL saaqndwoa asn o7 Moy tuoTyBoNp|-gTeg quepnig TeoTpen "9 ‘uosvalp “eqep HOE *T 06h °9 259°¢ q HIN TTCOOWdx UOTIVZTAeeuyeo Oetpaeo Jo stsATeue suTT-u9 guepnys Teotpen "WA ‘WezTaD *uoLTpouny Tafsuedy AMT pue MoT] pootq Areuowmnd TE6°S TIT "92 One" OT T HIN TIE x Burmese Loy SenbTuyoay UOTIN[ TP 109eoTpuT quepngs Teotpay °c Fouren "S900 Cqns Teuiou pue squeltyed ofqeuyse yqim suoTssas €ETO HES°R G65°¢ + ILIN TTSOOUN SUTINP SONTeA soUeYS Tsar ABMATE 104 [LOW quapnys TeoTpay *) ‘ueUpTed “snteydosa LoH* TT T26*02 SLB" L q HIN TI£OOMx [oug FO sTsTeqstaad Arepuocdss jo uoTyeuTUTEZaG quepnas Teorpey ‘gq ‘uueuzug ‘Adeaeuy Jo sTeoe “emorqaed Ur - SanTeA PTay-ATuCuMOD ULe4Z—eD JO 496°O TL RT 29S°9 t HIN TTEOOMNx | STSBq |yQ UO SpxeM oTIZeTYOASd oztaeqoereUD qUSEPNyS TeoTpen ‘ce ‘aTepsuta "apnyrTuren (Wty) esuodser payoas pavereae yo yuauaouey OOT*T Ogh BE L2i°gt qt HIN TTSOOUN® “us pue UOTIUELIe UseMzeq TrysuotyezTey quepnys TsoTpen *p karo "squeTqed paaoqfuow uo seuny esh°T TLG EE SHE OT q HIN TISOOWx Aqize oBtprwo JO uoTyTUMOD|T oOTYRUMOYNY quepnys Teotpan “a mug £00°T QlE°92 LTO° LT nh HIN TTS OOHH* "aot UL sazoum4 UO e4ep Jo uOTIeTNO LED quepnys Teotpay “ep Geqsaug "UOT }BI48 LULUpE oTTQnd gig’L TSE"0 2620 t HIN TI£OOHH* | OZ pesn 9Q 04 STepow TeoTywusyyeu Futstaad quepnys TeoTpew ‘e Gaaateg *quowqreday soqqeuen ut 260°2 GE0°SOL BRO “Art 4 HIN TTSOOUNx Squepnys TeoTpeu woz uoTyonaAysuT reqynduog qUuePNyAS Teotpey ‘ad ‘weueyong yooTq aed aqnutweged szad . s4ua0 OT’ 38 ques T* ye % (SHUT) y AtoBoqey -- Toouos Teotpey ‘uoTyeonpy yuepnyg Olje#eqoys yooig (4) sejnutuereg (Supa Agzosd | yay Tenuuy Anuaty 2aqunN QULLL EOULOYd NOT INL LShi YOLVOLISHANI sseoo. ~aqRy quaqing UOT {LOT ZT UapT UNGWINVda T ENGNG T 0% HR LNdWOO Aas fl) TsHOdd OS LOVECNOD YO LNVNO LOSHId __ cOWSA FGHNOSEM ME LAIWOD T sli Lily peqeAoy potaeg SLONLONd YES Teng LATCn dO A¥VANNS us oO 1 q Oo *Zasn TenptaTput auo wey} eaop SutTqatoddns yueayg » gZ sa rad ent = 8 gi6°O $Q0"? 058 °O t HIN TTS 00x “sasmaqaouTys Jo uoTzeoT dea 94g uo sotpnys quepngs Teotpan *s ‘Tuqes ped a 8 "SsqseTqorqty ueuny ua pemnyMs Jo aouaoseues aqeuTy—Tn pue ‘quewdo ¢60°0 9ST°T 009°0 q HIN TTEOOM -Teaap “YyMors ey} Jo BuTTepow TBdT4sT ABS quepnys TeoTpen, "ad Temas *soueaqueul [T90 woay paltyzrand usaq 250°T LLE*Qe Glo Lt q HIN TTSO0U* sey yoTya audzue asedtjtoudsoud ve sutApnys quepngas TeoTpen ‘Q eT Tepusog *syuapnys Teyuep goo"o Tle"2 26g" q HIN TICOOMex AOE SOLYSiFRysSOTG UL UoTyoONAysUT Teqnduoy quepnys TSoTpen "y “GTgEes geT°9T 269°T6 OTe 6E t HIN TtGOouds | *APoTOTQ uoTzetndod pue ABoTOos uo setpnys quepngs TRoTpen "gd ‘syoug “uotTydeored 219°O ¢TT‘O 450°O q HIN TTFOONN* | yooads Temrou {ASoToyWed avenge, pue yooads quepnys TeoTtpenW ‘mM ‘Teyquasoy *4TUN saeg ATEUOLO) 343 09 SyueTyed sTeu jo 420°O o"0 o°0 + HIN Tigooudx | uotyeqdepe TwoTsoToysAydoyossd ayy BulAépnysg quepngs TeOTpow ‘ya Prleguesoy ‘oqo ‘SoT4sTqgeys ‘suOTyeTROTeO BYyYeP ZOT*O 600°6 062°S t HIN TTSOOMe | 10ujO STpUEY pue sfkesse Jo sy TNsed ayeTnoTeg quaepnys TeoTpenl ‘qd ‘uTqtey ‘faupTy pasnjued 344 UT sTsaua8pawoon[2 La¢°o 960°0 ogo"o t HIN TTEOOUux stsouezouue Jo dyysuotqyeted-aequt jo Apnag quepnys TeoTpEN ‘a Geddoig 210°O oO 070 + HIN TTEOOUNx *foueufead soy suotTzeatqou yo Apnys quapnys Teotpen "9 SOOT IIOg *squefe oTBoTooewureyd SNOTTeA JO sdoqyowerud uoTyouny se [nosea €o¢°O 066 °€ GoZ's t HIN TT€OOUN* | -OTpTeo Jo sjes vqup jo sysATuue THOTASTIBIS quepnys Teo Tpen “gs ‘edog *sesse suTT TeTTered Geer 2enS"@9 02°02 4 HIN TTSOOW* Ul SIAaTTyNO pue sTenpTsaz Jo uoTyenTeaq quepnis Teotpey! "p fgraqeg ‘Apog vsuMYy ayy UTYZIM WSTTOqeyeu uTTNsutT Qe "0 906 * 2¢ oOT6°"g q HIN TISOO MEK doy Tepow sarsueysaduos e jo uoTyeTnuTOg quapnys Teotpean ‘qd ‘saaqed ‘wogsks TeoT#oTotsAéud ayz jo uotqyeaade aU} UT STeUETS TaACOSTp O04 squaAs Temou +00 °O 0°O 0°O q HIN TIEOOMe pue Teuowzoy Jo uoTyoRUayJUT Sy} UC saTpNyS quepn|s Teotpen "wa “TTePpo "waysks SsnoArE au} JO UOTYZOw |Y4y eyeMTxoudde 04 suomoeu 200°O 00 0°O q HIN TTSO0Udx JO sjes egzeT go suoTzeaedo ayy BuTTepow quepnas TeoTpan “W “eanN *szeyour red Ege "0 Tet *T2Z S69°€T 4 HIN TICOOWNx | OTueUxpoUsY jo STSATeUR TROT|STIeYS WIOJTed quepnys TeoTpan ") “eTON . *sTsouzelp TerquedeajszIp 48 ELK tT 260 °6T AT°S t HIN [TSOOddx pouty werZoad pasuq-azeqgnduoo Jo quowysTLaEysa quepnys TeoTpen 1 ‘a0qseN *aseasTp QSE°6 SLzt2 2le°o t HIN TUZOOM oeTpreo pues AeaTT jo sTsouzeTp teqndmo5 quepnys Teotpeyw ‘S eTTIW “guBnytaeu jo suoturde pue U}TM eouetzedxes ATeyy BuTpresez suetotsAyd gt2*2t egL*Zot 219° LS t HIN TTS COUN ajzenpeis pue syuaepnys Teotpau yo Aaams juepnys Teotpen w ‘ddtt YooTq zed aqnutuesed rad « $que0 OT’ 4 quao T° 78 t (dyad) 4 Aro#ayeD -- Toouss TeoTpay “uotTzeonpg” yueprys (Mjewedoyg YOoTg (y)soqnutuezeq — (suTM y¥) SeqnUTyW Rao? | quy penuay AoUSSY Tequngl WILT Lowfoud NOTLALILSNI WOLVSTLSAANT ssao00y [BuTumey -ayey quering UOT PBITIT PUPIL UNIWLYVda do INGWdI Md WaALAAWOD zesn LYOddAS LWYINOD YO INWHO Lodula id/oi/n - Ol/LT/h peteaon poyaed SLouLodd Yasn TWACLAICNI AQVSN AOMNOSTY BALNAWOo 40 AUVWNAS (103) uy 7 a . . : . *YorTasar al0o JO .Tedyy mB 4S0"SE geT HOE IWLOL~d 1s *Zasti [BUPTATPUT UO UeYy Saou BuTyaZOddns yueZ9 x “dayew 3 HHg'eh 260° ST 9 HIN TTSOONNx. -oajpoads sseyl coy sumagoid jo qyueudotasaq Aays Tuy xe WRUTITIS moe g 5 3 ‘oanjgonays eTnoeTou Sutonpep azo pesn £3 2q TTIM deqauoryoadg ssew faaqoworqoeds OM ggorz 00g" LLT LSL*6S g HIN TISOONM SRW Joy sueazoad Jo quemdoTesed soTqouey eH WTEIS “szajoworqoeds sseu jo szeyauered suptqgeaado 349 jo Torquoa zaynduion feaqoeds Gee 60T*SOT igo"€e 9 HIN TIGOOMde SSW UCTINTOSeT MOT PUB TITY JO Burprovay AAS TUT) wer SOY ‘sdeqouoayoods sseu Jo szojouered Butyeaade aya Jo Torquoo szaqndwoos ferzoads 00£ °O gol’gon eT 6 9 HIN TTISZOOUNx SSUM UOTINTOSeT MOT pue YyETY jo Sutpsooay sotqouen xe 'M ‘SpToufsay *suOTOBaaqUL Snip aTqeatTsaapim Burqueasad ye pourpe ABOTOORUTA YI THT 02 £66" T6S 626 *O0T 9 HIN TTEOONN% ueaZoud peseq-azaqnduoo jo quoustTTqe4s7 Teorut rg xK'S MUaYOD ypoTq aed [aqnutwesed aod = sua OT Ww ques T* 48 9 (Gaga) 9 A1099729 -- sTeuTuey eutynoy “yoavesay az09 B66 "Sh 909 "TOOT 21g°QlT TWLOL-@ns "sashTeue Teotwayo suTqnog fvaqjoeds saqeu OSh OT goz*99T anes G HTM TTCOOUNx | -T4otodouqoeds pue eaqoeds sswu yo stsATeuy AZqS puRBUD xe HY “UBUTTTIS ‘sosf[eue Teotmeyo eutynor feaqoeds zrajau €2T'St Cae Qhs 819 "SS g HIN Treooddx | -TxoTodoajoeds pue eaqoads ssem jo stTsATeuy Aaqs Tuayo xe fSs0y *sosATeue Teotuays euTgnor feaqoads azeqeu Stk QT HST G2 21g "68 g HIN TTEOOUd* | -TxoTodorj0eds pues eayoeds sseu yo stsATeuy soTqeusy xx 'M “spTousey yootTq aed aqnutuased zed $ (Haud) ¢ Aro#aqen -- our4)]Teey “‘yorvesay aaop squse OT’ 4e qued 2/To' ye G2L"THT 290° 99QE 26L°SOHT TWIOl-ans sanbtuyoa4 STSATeTP uUMTZqTTTnbe Sutsn {sTseyzucs 600°0 oo ronae) + HIN TTCOOUNx | Ueydoqdéry yo wstueyoou owxzue 93 Butépnag quapnys Teotpe “gd “[TOONSTM ett’o HITS S19 °T t HIN TIS OOUNe “(UTBAYSUCD SUT B Tapun suoTSToap yuapngg quepnyas Teorpey ‘H ‘seuoUl "Torques Aroyeatdsar ane Le LOL Teg BAG BEL 4 HIN LIS00edx uo UoTyoe Snxp oTynadesey, qaadzequy quepnzs Teotpew ax'5 ‘uosuBng *sqguetqzed queTdsuer} Aaup}y JO setpngs TeoTZoTotsAyd-otaos 09 "O a’o 0'0 t HIN TISOOUNx feanjonayzs ATTwey Jo Apnys Teqyueutuedxg qUaPNgS TeoTpew "ya yy TUS *sUOTZTPUCO TejuemticeitAue efueyo 04 sT [eo of sBnap duyaoysUyUpe PUB STTAO Teal TenpTATputT ean" O 018 °6 OLN th 4 HEM TIS00 ux FO syeeq UseK}eq STeAIaqzUT Jo Juauemseay quapngg TeoTpew ‘y fapeqTouTs yooTq sad aqnutuazed sad ques OT" 38 que. T° ye 4 (dad) 4 AtoBafe -- Toouogs TeoTpay ‘uoTyeonpg quepngg (jevetoyg yoorg = (y)semutuezed SUT Y) SOQru LW Agod | *ypuy Tenuuy Aauasy zequny WLLLL Log todd NOLLALILSNI SOLVDILSHANT ssaooy [Buiusayl ~8 zed Yetzny) UOT PROT JT }USPT LNW LAV ds 1 NANT Oe YaALNGNOD Tasty GuCddAS LOVEINOD HO INVYO LOGNTG SOVSN Woe padaao, potaad SA VOCLALCNE Sad WALNAWOO AO AMVWWNS (104) uN oO 1 q “UOTPSSIT 9100 JO 4TCdex o “Zan TENPTATPUT suo Ue ezom ZuTyszoddns wer »% ° fe 8 *szepuajjyo xas gh JO SeTIOUsSTY Tenxas ey UT eouRoTyTUBTS jo Be 962°0 nell SLI Tt HIN TIZOOUUx | Saoyoey Jo Buryseq TeotysTyeqys pue stsATeuy faye yypssg ‘a Tregsag pen Ag *‘sassaooid Areuot4nposd ynoge suctyolpead vue Tge"0 982°9S Jolt TT HIN TTSOONUx quenbesqns pue suotqetndod fo suotqeTmuts sot qauen "Tl FTTRARD *sqzroder TeoT4ysSTye4s TOF Sutssacoid eyep paseq-aeqndmos pue TRAeT i482 059 °6 gLS°OTT 2$9°QT TT HIN TTcooddx | UOTPyeMZOsUT JO poyZoM WLOFLUN B JO UOT yeoID ABOTOIN ‘a ‘aeTang “ws TOLYOTp TeTMoits aryeuseuw jo suotyeottTdde Teotmayo Tes°s 621°9T GETS Tl HIN TTEOOUx -OTq pue TeoTwayo oTUeFz0 Jo WOTJEZTTITAN ARYS TUBUD ‘ad ‘Saequeuung “UBAPTTYO JTooyos ArequeweTe uo ZuyT4se4 UuoTsTA pue 96T"S Teh L9 GSH TZ TL HIN TTISOOWNe Sulreey wory stsATeue pue uotyoaTrToo eyed | Surree]] pue yosedg ‘ad “Te yootq zed | aynutwesed ued Tr (ad) TT Ar03p9eD -= sTRUTUIay eaufynoy “oaforg 4OTTd squeo OT’ 48 ques T° 38 --- eee ef ee ee ee ee ee ee ee ee ee ---- oboe ee ee Ke ee ee eee ee eee ee ee ee ee ee ee ee ee eee ee ee ee ee ee ee2°OT eSl"9e¢ Osl* St TWLOL-d ns "UOTIOST TOS BYBP ZO OORT 343 03 ATOqesaqeT 600°0 26$°O 21g °O oT HIN TICOOUNx FEOTUTTO 943 UT qUeUMAysUT aBaeT B BuTQoouu0D ABoTOYYEg “eH “reussng "18quad TeoTpaW progue4g ayy ye wayshs uot yeRuzoyur ZQT"O Tense egg h oT HIN Ticomnix | Aoyezogey peseq-regnduco we yo yUeUYSTTqeysg fBopouzed xe H “reussng *euouousud 8T0°O 0°70 o"0 OT HIN TIS OOHdx oTydersoTeydsousoryosTe jo BZuTpueyszepun ABoToOIMAN "Ss Poamazeyg "ze qUa9 TBoTpaW paroyueys oy ye weqsks uoTyRMILOJUT €96°0 S19°0g O¢h "HT OT HIN TTEOOUd, | AtozeaogeT pasvq-aeqnduoo @ Jo jusUYsTToe4sa Axqeqyossd °N “ewan ‘USIPTTYO Teutou pue oTXeTsAp ut guauoduos uoTqoartp e& ZutTqerodaoout timmT4s 99% °6 OT9°96 20° LT ol HIN TTEOOUNe | Tensta Aq peyoas sasuodsez oTY jo uostreduog Kaye pyoks g “Ty vos reydoew o°O Q6E °2 488 °O OT HIN TISooudx f(s, aay) sesuodsey peyoaq peBudeay jo saytpnyas Apetyossg "T fosraygoen sueysks TeotsoptotsAyd AgaBammg 2go°o o9t*TT gle *t OT HIN TIE COUN ayy JO setqsedoud snoTzea Jo uoTqye TMs TE TNOSSAOT PAG) "s ‘uosTaog aqnutwesed sad aqnutuated aed — “ squad Ol’ 4B ques 2/TO' 4% ot (Tqad)| OT AtoFaqeD -- owt4| Teey “Qoofoud AoTTd wae eww ee bee eee eee ee I ee ee ep eee ee Ke ee eee ee ee ee ee eee ee ee ee ee ee ee eee eee inh’S6 229° 66€T 2TT"9h2 TWLOL-€Ns qumosoy aut yesedg spung aoTJJoO Ly L°e6 29 *66ET 2TT"9h2 g £4 ;saeatuy |} AQTsTeatug SUTTITA 2TUTTO *¢ faTs£og yooTq tad | aqnutwezed rad = squeo OT" 18 Le aueD q/T-T* 3 8 (TWLOL) g Ato#aqe) -- |OTIIO| BUTTITE OTUTTO “TooHos TeoTpew paosueyg (a)ewer0ys yooTd (4) saqnuqwered (Sufu a) soqnutm ~~ AaoF | -qury Tenuuy Kouaay TequmN AUIL Loaroud NOLEALILSNI HOLVOLLSZANT sso00y TuUTUMIEL —~248D quegig wor geo TS TAuEMT INALEVEEC GNAWd I NOM A LAdWOS Aasf, LYOddNS LOVELNOD HO INV) Loauta TL/at/y - olf hy patsao) pottad SEoTLOUd YASH TVA LAT CN GOVSN ADMNOSaY HALNIWOO dO AUYWANS (105) uN Ss QTE Ly 906 "QRTT GOT 992 TYLOL-a.ns "Zasn TRIpLALpUT suo UeYyR atom Buyqaoddns query » a 8 *suTUBTaW JO aanqonays oS se chore €6T° JBT GRO "6 ZT HIN TTCOOMx TeTMoeTou syy FO sTspow Jo uoTqzezeUan ABOTOVRULIAg ‘kh “Tarepouyqeuy, oP oe ‘astesTp ao Aanfut pazoo Teutds wit squerqed #3 GTT'OT HEL 212 696 "2S et HIN TTEOOUNx | UO Byep JO TRASTZZer PUB SPeI04s uOTZeMIOJUT ABoTOILN ‘ad ‘weaog| ie oO & i *sBop JO weqysks eyed oetpayo-Tevea ayy uo fraBing 410°S 440°0R 40S" aT et HIN TIcoowds |squeutredxe wor pauteqqo eqyep jo woT7zE4nduoy TeTNOSBAOTPIED ‘H fazeT) . *aUTOT pau pue ABoTOLsAydoumau ut smaTqord 04 spoyqjen KeS° LT Ohh ahe 619°S9 at HIN TTCOOMNx Setszas aut Jo uoTzRoTTdde ayy ul yoreesey ABOTOMMAN "Mm ‘Gosaen “uoT OUNJSApP Tappelq olueFomneu yyTM squaetyed : JO jusueSeusu pue dn mMoTToy ‘Testeadde 296° TT gro *nte 250° 16 ec HIN TTEOOUe TeoTUuLlo JO queussozdut ayy uo seTpnyy ABoTOIN °9 ‘ouTqueysuag yooTq aed aqnutueszed ized _— > queso oT’ 48 quse 2/10" 4% ev (Had) eT AgoBoQeD -- owty Teey | peqedtotquy surpung 82eG°SS 199°g2h $29 °61T TVLOL-GNS “sTooojoad Adearayjousyootpeaz Sutstuosd #SOu ayy JO UOTYBUTMIEQEp {sanssT} Teurou 2h °O 462°6T L9L°9 Tt HIN TI€OOuN* | Pie roumy ut sesuodsez oTyauTY ou, Burépnig ABOTOT POY "d ~remays *ZOTABYSQ TOYOU 07 Semmsveu oTYdess0TeydaousorqoeTe SuTyetas 102°9 902°6 006 *2 Tl HIN TISOOUd* | BFEP JO uUOTIENTeAe TeoTAsTABYS ayeTTVATITOW ABoTOINALT “1 ‘TTear0W "pave atj} Loy soBreyo feutotpay! aatqusasig gts *o oro 0°70 tt HIN TT SOOM. Teqrtdsoy 19quep TRoTpaW puojusygs JO Asarng pure £q4TuMUMIOD “T ‘uue pow "aZTT go geek 4SaTy Iyjeyy Buyanp squejuy jo yymors Teyoos pue ‘TeoTZortoyoksd ‘TeotsAyd uo eAusy 400 "O 0°O 0°o Tt HIN TLSOOUHx | UT SHeTITA @ Woz paqoaTToa eqep Jo stefTeuy Aryeqypssg *q “mewiepteT OC L*ST 916° L2 299°CT Tt HIN TTSOOUNx ‘spaooea Asdoqne jo TeaaTaqea Bed ABoTOUIed ‘qd ‘uLoy *szoumy juapor uo squeutaedxe 6SL"2 166° 2T 260 L TT HIN TICOONNx WoT BIep MOTE POCTA town, JO sTsAéTeuy ABOTOTQOTP EY ‘a ‘WeurTey *STsouze tp 299°S 220° LT ST6°L TT HIN TICOONNx PTAVeTYOAsd 04 wecoayL, ,saseg Jo suotywortddy Azyetyossg "ad MTayyosaty Qn *o 206°T 26 L°0 Tr HIN TTCOOUUs }."WUETQed, oTAyeTYOAsd paztaeqnduoo yonzysuo0D Aazqetyods q ‘WY UeUTITH ‘daats Suranp aqyeTNoTuad TexayeT 3 Wot] papaoosa sanea dxeys otseydoucw qumoa pur AyTyUapL 04 seaUTy 610°T Hen OT ZhQ ot TL HIN TISOOMe “noaqns uotytusoosz usraqqed yo quewdoTossq #ayepuoksd ‘gd ‘SaueH "sqoTppe uTosay FuTyear, UL suopeyyeu Jo agsn ayy uo T29°T neh S9 Leg°t TT HIN LIGO0ed* BISE84 TeoTysTyeqs pue uoTyeuMMs ByepP oTpOTAag ASoTOowmIE YT ‘y fuTaqgspTon *sasevasTp snoTyoazul jo Toayuoa faaBamg Z00*o 00 o°O TT HIN TT wetTemmmeu yo Aderayqousyoorpya go Apnis ABoTOTpEy ") “yey "SOTYST ISVS foUTOTpeW aATyUSAeTI 269°0 GET LT ozg* oT On OWL ‘2 HIN #SGh TWD -O}q UT Yoreeser pattdde pue TeoTqeroayy pue A} TunMO) "d worsg "hae 'O gos 'T 2gg°0 Gt 6L°2e2 GER HIN 2h T¢OdH “syoajep YqaTq UL £aqs TMOYooTY SoTrzetpad ‘A Pletpused yooLa dad sqnutwezed red CL Ado#aye -- sTeuTuaaL eutqyou ‘Teaosddy eqngtadurl Burpus. apuedsny squso oT’ yuao [T" 7 St (IVIOL) ST aqed TeurmaL eutquoy ‘Te V aqnqrqgul Puppued pep’ S (W)eFer0y3 yoold (i) seqautueseg (suqw %) seqnuqtW = Aao# [+ juny Tenuay Aauahy zoquN PILI Loafoud NOTIALILSNI WOLVSIISZANT ssea00y7 Teuputey, 734RD yueaang UuoTPEOTITPUSPT LNAALY Vda INGNdI (6a UaLNdWoo dasy INOdINS DOVMLNOD YO GNVHD LOAMEd S.LOs £LOUd FOVSN FOUNOSTY WALAIWOO FO AUYWANS ft Jot Maso ‘TyNCTATCNE peta AOD pOoTIad (108) uN So 1 4 cd FA 2 q : . me oOgT’°o g2g"e 1£28'T 6 soTUSTzFeIS °g Sortdeug oH ay 240°O QTL*O oTs"6 6 Bo Tous d nT ‘sarees or ag 9K0°0 66°C Lon’T. 6 fBopouDksg ‘a ‘saws ou ent oO 6£9°O LTE*O 6 soTsAug ‘y ‘soTaRuoS zeyueg oyereTesoy €TH°O 9TL°O 2gTt’o 6 aBaUTT paojyueyg “H “Tees 062° 09T°SS 202° OF 6 sotsAud ‘a ‘Noszty Jayuag LoyereTeooy O6T"h geez GS °TT 6 JeeUTT paojueyg “gd “sequoTy ZayUaD LoyereqTa.oy 102°T T6L°T2 260°TT 6 TeauT] psojuezs "? Saey 900°O 290°O ShO°O 6 ABOTOYOAS "y Uoszeq4eg €T0°O 1G2°0 2gt"o 6 ABoToyoAs *y ‘aosTeN 41g°2 90 °R2 eno’g 6 ssoutsng Jo Tooyos *m ‘soumen e4T‘O G2Qg°OeT eT*6T 6 A248 TusyD ‘H ‘TTemUODOW 090°O 61g °0 ogs *O 6 aouUeTOS sTeLTaqey “ad ‘TeSaren LT0°O 2270 S9T°O 6 &BoTOUDAS *q ‘Kqoooew S10°O 4TT*O 0go"O 6 kdoToupksgd "W ‘faddeqT JazpUeQ LoyeTsTasoy BES°T OTT’9 ORT" 6 azeoutT paojueqs *p ‘wom T96°T 916° LT 26n 6 6 oaysy pue orey “qd ‘uastrayor 9¢0°0 O6n°S ZEL*T 6 KBOTONOAS | *9 ‘uTTyoer $00 °0 0°o0 00 6 &ydosottud “m ‘sTareyH OT0°O 0°O o°o 6 ssauTsng jo Tooyos "pp SoTMpreH Jaya) LoyesaTa.oy ST2°OT Ln6°S6 OT9"6E 6 TeOUTT paoyueag “qd ‘uosaeysny ¢T0"O 69n°0 §92°0O 6 ABoTOYOAST ‘qd ‘euaery 2gn*o TS0°@ 262°T 6 84n4T4SUl eTZeure) "qd “‘yaog 900°O 0°O O70 6 ABoToyoAsg *s ‘umoag eng °O Ste! "ae ace" 6 MeT JO Tooyog *m fog 200°O 0°0 o°O 6 yoreasay suotyetadg *R GeoTted TOL T £26 "HS Slo°L 6 orysy pue omey *y ‘ouasy 699°0 ZeqT ono 6 Oaysy pue o1ey *y ‘orysy YyooTq zed | sqnutmaved saad > . squao OL ye |squeo 2/T-2° 38 6 (TVLOL) 6 4103098) -- yorsesey TeoTpamoTY-uoN pue TOoYDS |TRoTpeW-uUON proyie4s Q1)e8e104§ YSota (y)seqnutueseg (Sup y) seqnutW -Azo3 [-quy Tenuuy Rouasy ToquMl RIL Loaroud NOLIALIGSNI HOLVOLISGAR gsaooy TeutTuzay -34eD quaaang UOTPEOTITUSPT LNAWLY Vda Co LNA Ned HLAAWOO Tash LYOddNS LOVHLNOD YO BNVED LONI TL/OT/H - OL/LT/y =Peteacg potied (asn peqeTea YyTeoy~uON) ASN YHHLO SOVSN qOUMNOsaY UHLNdWOO JO AYWWANS (109) Grant No, RRCO311-0 Sectior ix LOE HH2T ETL HOEK! frye 1869 ose a$vsn gounosau|+ Twion anv 9R6 "6E Te2 919 SgL one a (28n pezeTer UTeEY-4oN) ASH WHELO 208" sh6 6Sh° B2GL1 026 °0eLh HSE SLOELOUT WASN TWACTALGNT LTT *292 ¢16°S9T9 BE6"696T 2b SLOWLOdd |HONVASTA TOO sqoaforg go Jequny 9R6 "6 Tg2"g29 SQL ong TWIOL yoreasay sTetTzea yey 2TS"0 TT6"T LlE "0 6 Toy Taqued ‘a PTeTIUIM STg°2 ehh 622 SRT "EQ 6 HOOSYW ") PpToyzepetm 269°T e6t°O GHE *O 6 XGANT ") “proysepeta £50°O OTe" LRO*E 6 ABoToyossg ‘ad “TexTeM yooTq aed aqgnupuezed zed (108898) <= asa otpdmotg 0 me Too! . Sque2 OT" 48 {syueo Z/t-2° 78 6 (TWOL) 6 AaoBeqe; Yorwasay TeoTpaulorg-uoN pue Tooyog |TeoTpew-uoN pzozuBys (d)eFe4039 HOoTY (y)seqnutwegeg (sulu .) SoqnuTW Agog | *4uy Tenuuy Aouadhy AOQUTN FILLE Lod fOud NOT GALIUSNI HYOLVOLLSHANT Sseo0or [eur “3429 UOTLEOTITIUSPT GNANLYVda 7 INGAdI NGG YaLNIWOD zasn LOVELNOD 4¥O LNVHD LOSHTC capt 7 Oefé (asn po BOL ULTSOY-UO! fT pedeaoy potsad TTHEG HOVSA FOUNOSAY BALNMMWOO fo AUYWWNs (110) X. MEDICAL CENTER SURVEY RESULTS OF "SURVEY OF COMPUTER AND DATA PROCESSING NEEDS AT THE STANFORD MEDICAL CENTER -- NOVEMBER, 1970" A survey was conducted in November and December, 1970, to determine the nature of current and future computing requirements in the Stanford Medi- cal Center. Questionnaire forms were mailed to all department heads a long with requests for future distribution within each department. Sixty- three forms were returned and incorporated into the following data. Responses came from the following sources: Department Hospital Administration Anesthesia Biochemistry Community and Preventive Medicine Genetics Medical Microbiology Medicine Neurology Pathology Pediatrics Psychiatry Radiclogy Surgery Other Campus Departments on i [et Wf mom FRE OW FEE {& TOTAL Brief summary statements of results are presented below: 1. About one-half of the respondents noted that the most important com- puter use to them was "general program development" or "routine calcu- lations (super desk calculator)." This indicates that many users needs might be solved by compilers such as BASIC or APL. One third of the res- pondents felt that "automation of current laboratory of clinical proce- dures" was of priority "1", "2", or "3" on a scale of "6". About 16% felt that the automation of laboratory or clinical procedures was of highest priority. (111) X. MEDICAL CENTER SURVEY 2, Of those responding, about 50% were current users of ACME, 20% of Hospital ADP, and 20% of Campus Facility. Ten persons or 16% indicated ownership of a dedicated system. 3, 58% use the PL/ ACME language. 21% use no computer language at pre- sent or left the question unanswered. 4. 75% indicated plans to replace an existing manual system with an automated system; but the automated one will add new capabilities. 5. 70% indicated the applications were running now; 45% stated that future applications were planned. This was essentially corroborated by another question in which 43 persons stated that programs were al- ready available and 19 indicated programs were not yet available. 6. The single largest limitation on achievement of computing goals was "Your own time or direct knowledge in this field." Other choices available on the form were hardware, system software suppert, and skilled applications staff. 7. Instrument readings and Laboratory reports were the two most commonly checked sources of data for respondents. These selections were followed by personal interaction and medical records. The items checked by the fewest were doctor's orders, verbal reports from staff, and patient charts. 8. Source of funding data revealed 21 from National Institutes of Health, 12 from Hospital or Medical Center budgets, 5 from private organizations and gifts, 7 from "Other", and 18 who skipped the ques- tion without answering. 9. The amount of funding available for computing was left unan- swered by 45 of the 63 persons. Of the others, 10 reported $0 to $10,000; 5 reported $11,000 to $20,000; and 3 indicated over $35,000 per year. 10. Twenty responders or roughly one-third reported plans for real- time data acquisition or instrumentation control. 11. Several persons indicated more than one choice on staffing plans. Total responses were 25 to hire own staff, 32 to use staff from central facilites, 2 to use commercial firms, and 18 to "do my own programming". 12. Most respondents felt that computer unavailability could be toler- ated for four hours or more. Only } persons indicated that downtime on the order of minutes was unacceptable. Slighly more than one-half reported that manual back-up procedures would be essential. (112) X. MEDICAL CENTER SURVEY 13. In response to the question, "Is your data used to prepare patient billings?" answers were 9--Yes, 48--No, and 6--No response. 14. Nearly three-fourths of the respondents indicated no contribution of information to the patient medical record. 15. Concerning the sharing of information, 36 replies reported sharing of data with less than 5 other persons, while only 9 reported sharing with more than 15 persons. 16. One half of the sample would like to receive the bulk of their data on alphanumeric displays. The second most popular selection of ourput media was printed reports on special forms. 17. 24 persons stated that special precautions would be required for their files due to standard practices, legal, or audit considerations. 18. Access to filed data must require a few minutes or less according to about 70% of the sample. Analysis of Medical Center Computer Capability Requirements A more subjective analysis of the survey data written by Tim Coburn 5th year medical student, is presented here. The problem facing the Stanford Medial Center can be considered as a question of how to best invest roughly two million dollars a year cver the next five vears in information processing services. I. The survey has indicated that the requirements or applications for computer capability at the Medical Center fall into eight general cate- goriess Requirements Basic Parameters Reduction of physiologic data a,e Reduction of chemical data a,d Machine retreivable storage, "library" b Super calculating machine e Pattern recognition a,c Accounting and administrative b,e Modeling and simulation b,e Process control d CON nw FW MH (113) X. MEDICAL CENTER SURVEY The most basic parameters of computer systems are: a. high, or rapid input b. high output ec. sophisticated computational capability d. fast response time e large storage facility All of these parameters are generally desirable, but they are desirable to different degrees for different applications. The small letters following the eight types of applications denote the more important par- ameters for the particular type. The parameters to be emphasized are: High input, high output, and large storage capability. II. Which parameters should a medical center computing capability be designed to emphasize or not to emphasize. A. Not the super calculating machine applications. These can be handled by the main Campus Facility which is indeed designed for this type cf use, B. Not the pattern reccgnition applications. Sophisticated types of pattern recognition are still quite esoteric in medical research and treatment. There are other facilities at Stanford where these interests can be pursued. C. Not modeling and simulation problems. Here again these applications are tco sophisticated to merit primary consideration in design of a gen- eral system. D. Not reduction of chemical data. Problems in this area are currently engineering, design of suitable transducers, rather than computer prob- lems. E. Wot process control. These are also engineering problems even _ though their solution may incorporate computer capability of a fairly trivial nature. The primary applications for design consideration are therefore: physiologic data reduction, library storage, and accounting. TII. What are reasonable levels of these primary design parameters? A. Input requirements can be roughly approximated by estimating 20 patients or subjects monitored by 5 sensors at 1 ke per sensor. Total input capability needed = 100 ke bytes continous. (114) X. MEDICAL CENTER SURVEY B. Storage capability can be similarly approximated. 100 ke x 60 seconds/minute x 60 minutes/hour x 8 hours x 200 days. Total storage requirements per year = 5 xX 10" pytes. C. Output requirements may be estimated by assuming 100 users each capable of absorbing data at 1 ke. Total output needs = 100 ke bytes continuous. Ty. Cost and feasibility of meeting these needs. A. The input/output needs could be satisfied by a completely decen- tralized system of 100 small computers, but this would only provide about 108 bytes of storage. The cost would be roughly Ok per com- puter per year averaged over 5 years. This includes software. Total cost of completely decentralized system = h million/year. B. The present cost of computer capability is roughly e million/year. 1.5 million = ACME and Hospital Data Processing Systems. .5 million = Small computers and their software. C. The design problem consists, then of achieving a 2 to 1 reduction in cost over the decentralized system, and an increase in on-line stor- age capability of at least 103. 1) Achieving a 2 to 1 reduction in cost is very largely a problem of software personnel (with engineering support). It ig a question of 50 rather than 100 people at an av- erage cost of 20k. 2) Storage capability in the range of 10" bytes is a major problem. Standard IBM tape units are too small by a factor of 1,000. There may be high density optical sys- tems available (see Precision Instuments Unicon). 3) Other hardware design problems should not be too diffi- cult, although an overall system concept may be unfam- iliar to many "computer" people. VV. Conelusiocn. Centralization of the Medical Center storage facilities could provide a significant gain in cost per unit of data accessible, assuming that the foregoing t/o requirements and size of storage are achieved. However, even with these assumptions, careless design and implementation or ex- ternal pressures could quickly reduce the net gain to zero or worse. The probability of a net gain from centralization without meeting the above I/O requirements or storage size seems unlikely. (115) XI. PUBLICATIONS - FY1971 Becker, J., Y. Thathachari, and P. Simpson, "Molecular Conformation of L-DOPA," BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNTCATIONS, vol. 41, pp. 4bh-hug, Bernfield, M., "Chromatographic Properties of Pyrrolidone Carboxylate-tRMNA, " submitted to JOURNAL OF BIOLOGICAL CHEMISTRY. Bodmer, W. and L. Cavalli-Sforza, "The Genetics of Human Populations," FREEMAN AND COMPANY, in press. Bodmer, W. and J. Bodmer, "Studies on African Pygmies IV: A comparative Study of the HL-A Polymorphism in the Babinga Pygmies and Other African and Caucasian Populations," AMERTCAN JOURNAL OF HUMAN GENETICS, July 1970, Bodmer, W. and B. Gabb, "A Micro Complement Fixation Test for Platelet Antibodies, ' HISTOCOMPATIBILITY TESTING, July 1970. Bodmer, W., J. Bodmer, A. Coukell, FR. Payne, and E. Shanbrom, "A New Allele for the LA Series of HL-A Antigens: The Analysis of a Complex Serum," HISTOCOMPATTIBILITY TESTING, July 1970, Bodmer, W., J. Bodmer, and M. Tripp, "Recombination between the LA and 4 Loci of the HL-A System," HISTOCOMPATIBILITY TESTING, July 197¢c. Bodmer, W., P. Mattiuz, D. Ihde, A. Piazza, and R. Ceppellini, "New Approaches to the Population Genetic and Segregation Analysis of the HL-A System," HISTOCOMPATIBILITY TESTING, July 1970. Brown, B. and L. Soyka, "Survey of Drugs Administered to Nine-Hundred Hospi- talized Children: I. Relation to Age, Sex, and Diagnostic Categcry," JAMA, 1970. Bussien, R., "L'informatique Medicale Aux =tats-Unis,'" MEDECINE et HYGIENE, November, 1970. Cohen, S. and C. Miller, "Non-Chromosomal Antibiotic Resistance in Bacteria: II. Molecular Nature of R-Factors Isolated from Proteus mirabilis and Escherichia coli," JOURNAL OF MOLECULAR BIOLOGY, vol. 50, no. 3, pp. €7i- 687, June 1970. Cohen, S. and A. Chang, "Genetic Expression in Bacteriophage \ : ITI. In- hibition of E. coli Nucleic Acid and Protein Synthesis during \ Devel- opment," JOURNAL OF MOLECULAR BIOLOGY, vol. 49, no. 3, pp. 557-575, May 1970. Collins, R., M. Weinberger, C. Gonzales, G. Nokes, and J. Luetscher, "Catechol- amine Excretion in Low Renin Hypertension," CLINICAL RESEARCH, vol. 18, p. 167, 1970 (abstract). (116) XI. PUBLICATIONS - FYL971 Constantinou, C., E. Briggs, R. Dale, and D. Govan, "Real-Time Digital Computer System for Ureteral Physiology Investigation, " URODYNAMICS, Chapter III, Academic Press, New York, in press. Constantinou, C., and E. Butler, "Medical Application of Computer Displays in the Rapid Examination of Developing Abnormality Patterns in the Kidney," PROCEEDINGS OF THE INTERNATIONAL SYMPOSIUM OF THE SOCIETY OF INFORMATION DISPLAY, Philadelphia, May 1971. Constantinou, C., J. Sands, and D. Govan, "Computer Monitoring and Control Instrumentation in Urology Research, '' PROCEEDINGS OF THE 6th ANNUAL BIOENGINEERING SYMPOSIUM, Fort Collins, Colo., May 1971. Crouse, L. and G. Wiederhold, "Interactive Use of Timesharing System for Medical Laboratory Support," presented at the San Diego Biomedical Symposium, San Diego, Calif., April 1970. Dong, =., dr., and B. A. Reitz, "Effect of Timing of Vagal Stimulation on Heart Rate in the Dog," CIRCULATION RESEARCH, vol. 27, no. 5, November 1970. Fries, J., "Experience Counting in Sequential Computer Diagnosis," ARCHIVES OF INTERNAL MEDICINE, vol. 126, October 1970. Gersch, W. and G. Goddard, "Epileptic Focus Location: Spectral Analysis Method," SCIENCE, vol. 169, po. 701-702, 1970. Gersch, W. and E. Dong, Jr., "A Note on Warner's Vagus Heart Rate Control Model," CIRCULATION RESEARCH, 1970. Gersch, W., D. Eddy, and &. Dong, Jr., "Cardiac Arrhythmia Classification: A Heart Beat Interval-Markov Chain Approach,” COMPUTERS AND BIOMEDICAL RH¥SEARCH, August 1970. Gersch, W., “Spectral Analysis of EEG's by Autoregressive Decomposition of Time Series,’ MATHEMATICAL BIOSCIENCES, vol. 7, pp. 205-222, 1970. Gersch, W., "Estimation of the Autoregressive Parameters of a Mixed Autore- gressive-Moving Average Time Series," IEEE TRANS. AUTOMATIC CONTROL, August 1970. Glick, D., K. Marich, P. Carr, and E. Beatrice, "Laser Microprobe-Bbmission Spectroscopy," ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 168, pp. 507-509, 1970. Harman, C. and C. Raymond, "Computer Prediction of Chronic Psychiatric Patients," JOURNAL OF NERVOUS AND MENTAL DISEASES, vol. 50, pop. 4OO- 503, 1970. Harman, C. and K. Meinhardt, "A Computer System for Treatment Evaluation at the Community Mental Health Center," 2nd Bay Area Regional Conference on Program Evaluation in San Francisco, Calif., January 1971. (117) XI. PUBLICATIONS ~ FYL971 Harrison, D. and J. Ridges, "Nomograms for Determination of Mixed Venous 02 Content and O02 Stepup in Atrial Septal Defect," AMERICAN HEART JOURNAL, vol. 80, p. 575, 1970. Hillman, R., "The Teaching of Psychotherapy Problems by Computer," vresented at the American Psychiatric Association Convention, San Francisco, Calif., May 1970. Huberman, J. and A. Kornberg, "Enzymatic Synthesis of Deoxyribonucleic Acid, XXXV. A 4'-Hydroxylribonucleotide Binding Site of Escherichia coli Deoxyribonucleic Acid Polymerase, '' JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 245, vo. 5326, 1970. Kessler, S. and R. H. Moos, "The XYY Karyotype end Criminality: A Review," JOURNAL OF PSYCHIATRIC RESEARCH, vol. 7, pp. 153-170, 1970. Kriss, J., "The Long-Acting Thyroid Stimulator and Thyroid Disease," ATVANCES IN INTERNAL MEDICINE, L970. Kriss, J., T. Mori, and J. Fisher, "Studies of an in vitro Binding Reaction between Thyroid Microsomes and Long-Acting Thyroid Stimulator Globulin (LATS): I. Development of Solid-State Competitive Binding Radioassay Methods for Measurement of Anti-Microsomal and Anti-Thyroglobulin Anti- bodies, ' JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, 1970. Kriss, J., =. Glatstein, and J. Eltringham, "Serum TSH and Thyroid Function Following X-Ray Therapy in Patients with Malignant Lymphoma," CLINICAL RESEARCH, vol. 18, p. 168, 1970 (abstract). Kriss, J. and T. Mori, "Rapid Competitive Binding Radioassay of Serum Anti- Microsomal and Anti-Thyroglobulin Antibodies: Measurements in Graves' Disease, ' CLINCIAL RESEARCH, vol. 18, p. 170, 1970 (abstract). Levine, R. and N. Kretchmer, "Conversion of Carbamoyl Phosphate to Hydroxyurea: An Assay for Carbamoyl Phosphate Synthetase," submitted to ANALYTICAL BIOCHEMISTRY. Lugzatti, I., R. Greenstein, D. Marris, and lH. Cann, "Cytogenetic Analysis o a Boy with the XXXY Syndrome: Origin of the X-Chromosomes," PEDIATRICS April 1970. Marich, K., P. Carr, W. Treytl, and D. Glick, "Effect of Matrix Material on Laser-Induced Elemental Spectral Emission," ANALYTICAL CHEMISTRY, vol. 42, December 1970. Melges, F., R. Anderson, H. Kraemer, J. Tinklenberg, and A. Weisz, "The Personal Future and Self-Esteem," to be published in ARCHIVES OF GENERAL PSYCHTATRY. Melges, H. Gillespie, L. Hollister, and J. Tinklenberg, "Temporal Disinte- gration and Depersonalization during Marihuana Intoxication," ARCHIVES OF GENERAL PSYCHIATRY, vol. 23, pp. 204-210, 1970. (118) XI. PUBLICATIONS - FYL971 Meliges, F., H. Gillespie, J. Hollister, and J. Tinklenberg, "Marihuana and Temporal Disintegration," SCIENCE, vol. 168, pp. 1118-1120, 1970. Mesel, E., "Direct Measurement of Intracardiac Blood Flow in Dogs with Experimental Ventricular Septal Defects," CIRCULATION RESEARCH, vol. 27 December 1970. ) Mesel, E., "Transducer for Direct Measurement of Shunts in Experimental Ventricular Septal Defects," JOURNAL OF APPLIED PHYSIOLOGY, vol. 28, no. 5, March 1970, Mesel, E., and M. Gelfand, "An Automated Data Analysis and Acquisition System for a Cardiac Catheterization Laboratory, COMPUTERS IN BIOLOGY AND MEDICINE, in press. Petralli, J., A. Kataoka, T. Merigan, and E. Russell, "On-Line Computer Testing," NEW ENGLAND JOURNAL OF MEDICINE, vol. 283, vp. 735-738, Cctober 1970, Reynolds, W., "Instrumentation in a Time-Shared Environment," RESEARCH AND DEVELOPMENT, vol. 21, no. 4, pp. 20-26, April 1970. Reynolds, W., "Biochemical Applications of Mass Spectrometry," Chester ITI, (ed. by Waller}, to be published by John Wiley & sons, New York. Reynolds, W., V. Bacon, J. Bridges, T. Coburn, B. Halpern, J. Lederberg, =. Levinthal, E., Steed, and R. Tucker, "A Computer Operated Mass Spec- trometer System," submitted to ANALYTICAL CHEMISTRY. Sachs, D., E. Jellum, and B. Halpern, "Determination of the Stereospecific Hydrolytic Action of Pepsin by Nuclear Magnetic Resonance Spectroscopy, ” BIOCHEMICAL AND BIOPHYSICAL ACTA, vol. 198, pp. 88-92, 1970. Schneiderman, L., S. Baylor, L. DeSalvo, and P. Wolf, "The 'Abnormal' screen- ing Laboratory Result: Its Effect on Physician and Patient," AMSRICAN FEDERATION OF CLINICAL RESEARCH, 1970 (abstract). Sibergeld, 5., N. Brast, and E, Noble, "The Menstrual Cycle: A Double- Blind Study with Enovid and Placebo," submitted to PSYCHOSOMATIC MEDICINE. Silvers, A. and W. Sanders, "Digital On-Line Computer Display to Investigate the Structure of Metabolic Systems," COMPUTERS AND BIOMEDICAL RES=ARCH, vol. 3, pp. 133-145, April 1970. Smith, R., "Discussion Tasks as a Measure of Family Role Structure: Implica- tions for the Study of Pathological Families," JOURNAL OF PSYCHIATRIC RESEARCH, October 1970. Smith, R., "Discussion Versus Note Passing Tasks in the Study of Family Role Structure, " JOURNAL OF NERVOUS AND MENTAL DISEASES, March 1971. (119) XI. PUBLICATIONS - FYLO71L Swanson, G., J. Bellville, T. Carpenter, and D. Snider, "A Hybrid Computing System for On-Line Respiratory Studies," published in the PROCEEDINGS OF THE SEVENTH ANNUAL ROCKY MOUNTAIN BIOENGINEERING SYMPOSTUM AND EIGHTH INTERNATIONAL ISA BIOMEDICAL SCIENCES INSTRUMENTATION SYMPOSIUM, Denver, Colo., May 1970. Swanson, G., J. Bellville, T. Carpenter, and D, Snider, "An On-Line Fybrid Computing System for Dynamic Respiratory Response Studies," COMPUTZRS AND BIOMEDICAL RESEARCH, May 19/1. Thoman, E., S. Levine, and R. Conner, "Lactation Suppresses Adrenal Conti- costeroid Activity and Aggressiveness in Rats," JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, vol. 3, pp. 364-369, 1970. Thoman, E., A. Turner, P. Leiderman, and C, Barnett, "“Neonate-Mother inter- action: Effects of Parity on Feeding Behavior," CHILD DEVELCPMENT, vol. ho, pp. 1103-1111, 1970. Thoman, E., and S. Levine, "Effects of Adrenalectomy on Maternal Behavior in Rats, '' DEVELOPMENTAL PSYCHOLOGY, in press. Thoman, E., C. Barnett, and P. Leiderman, "Neonate-Mother Interaction: Development of Earliest Feeding Patterns as a Function of Parity,” CHILD DEVELOPMENT, in press. Thoman, E. and A. Korner, "Effects of Vestibular Stimulation on the Behavior and Development in Infant Rats," DEVELOPMENTAL PSYCEOLOGY, in press. Tinklenberg, J., F. Melges, L. Hollister, and H. Gillespie, "Marihuana and Immediate Memory," NATURE, vol. 226, pp. 1171-1172, 1970. Wiederhold, G. and G. Breitbard, "A Method for Increasing the Modularity of Large Systems, '' IFEE COMPUTER GROUP NEWS, vol. 3, no. 2, p. 30, April 1970. Wiederhold, G., R. Frey, and S. Girardi, "A Filing System for Medical Research,’ BIOMEDICAL COMPUTING, vol. 2, April 1970. (120) TABLE A XIT. "TL6T Trady ysnozyy O/6T ysn@ny so [Teq904 syjUOW oUTU 4saEZ UOdnN peseq sanTtey 04 autg URsW poqoefoug (TL6T ‘Atop - £eW) x ‘daak yoeo Jo YQuoW sues 04 peTedwoo se oaNTTefz 04 OULy UROU 4soqd = YOMBTY peutTzepun iG’e go soqgoey @ AG peAordut sam[tey arem “prey SuTpnNTOuUT suoseed TTe FOZ woeqsks ANOV 8UQ AOS WaLW “ty JO TOqoeZ e Aq peacaduy saemparey Io FALWN *NOISNIONOD See Bee Bex BS Tex 2°99 6°08 L745 €°9¢ Luge OTST TKS ene 0°62 >T/6T-O16T tH He 9’ ae 4°09 9°62 O° Le o'°GS O'6¢ OT ah O'et G°9¢ lL Lt ces O’OH =F OL6T-696T ederoay Tar une AeW aidy Len qa uel oad AON 490 adas suy Tenuuy HUVMCdVH *TONT SHeNTIva TIV Q'Onex 99K 9°9Sx O'9TEe O° CRT o'HOe L°gTe o'HOT o'HOL O's9e O'OJT OE "él %=Tl6T-Ol6T Gtg Ge 0° Sg 9°64 1°95 G*6¢ HeLa SLOT 0°96 ETS 2° Se e°GS S°STT t0l6T-696T ose LoAy Tne un Aew udy Ie qo ue Dad AON 190 adag Bny Tenuuy (SHNOH NT) TL6OT ‘QT Tlud¥ - 696T ‘LT ATOL HOT SHUNTIVA NEAMLTE ANLL NVA 0S/09¢ ALITIOVA AWOV JO NOSTYVAWOO HOVMIYVH (121)