VI. BUDGET EXPENDITURE DETAILS Direct Costs Only August 1, 1970- August 1, 1971- July 31, 19/71 July 31, 1972 1. Personnel Director's Office 46,597 48,645 Systems Programmers 78,379 76,213 Applications Programmers 41,749 47 5315 Research Assistants 6,940 7,394 Operations 21,953 54, 948 Secretarial & Administrative 12,355 13,220 Subtotal Salaries 237,973 247 5735 Staff Benefits 32, 9h2 37 , 384 TOTAL PERSONNEL 270,915 285,119 2. Consultant Services 800 1,900 (51) 3, Equipment TBM Rentals IBM 360/50 1052 Console Typewriter 1403 Printer 600 LPM 2050 Additional CPU (F) 2314 #1 Dir. Acess Storage 2314 #2 Dir. Acess Storage 2361 Core Storage POL Mag. Tape Unit 24.03 Mag. Tape Unit Control 2540 Card Reader Punch 270L Data Adapter Unit 2702 Transmission Control 2821 Control Unit VI. BUDGET EXPENDITURE DETAILS Direct Costs Only Subtotal 360/50 Disk Packs (I8M 2316/3-M) Terminals (2741) IBM 1800 add. units whe 1826 1856 Subtotal, 1800 August 1, 1970- July 31, 1971 635 8,397 OT 348 52,920 52,920 76,161 3,377 8,971 6,653 10,332 16,834 LO, 937 345 485 (16) 3,226 (12) 12,167 HAN 90 ie 36 ONSD \O WE 11,945 Unit Record 029 TOTAL, IBM RENTALS Miscellaneous Rentals Hazeltine Displays (excluding interface) 1,192 374,015 1,239 August 1, 19/71- July 31, 1972 Subtotal, main resource rentals 375,254 *includes 1 month overlap of replacement of four by purchased Beehive alphanumeric terminals (52) 365 ,825 TBM 2741's VI. BUDGET EXPENDITURE DETAILS Direct Costs Only August 1, 1970- August 1, 19/1- July 31, 19/71 July 31, 1972 Purchased Equipment IBM 1801 core 18,734 Prentice Data Couplers - 2 626 Textronix Scope Carts 333 Prentice Modems 4,182 Litton Printer (for Drug-Interaction) 4,053 Litton Printer (for Drug-Interaction) 4053 Alpha-numeric Displays (Beehive) (D-1) 7,270 (4) 16,936 DEC Disk Drive 15,120 Less portion of proceeds from sale of 270 x/y (15,120) Electronic Testing Equipment 1,000 Two 1200 baud data sets/interfaces for portable graphics 3,200 Small computer equipment pool 4OQ, 000 39,251 61,136 Data Set and Line Rentals 10,120 8,382 Maintenance (under outside contract) 6,559 8,670 Total Equipment 431,184 Kuh O13 4. Consumabie Supplies Office 3,500 4 000 Computer 8,500 10,250 Cables (Core Research Interface) 1,500 2,000 Total Consumable Supplies 13,500 16,250 5. Travel Jamtgaard--IBM Class, S.F., 7/14-21 37 Wiederhold-ACME Seminar, U. of Minn., 7/29 67 Jamtgaard--Wash, Univ., Computer Labs, _ 7/29-30 304 Frey --SHARE, Montreal, 8/17-20 574 Crouse --U, of Calif., Irvine, 9/18 70 Jamtgaard--U. of Texas Med. Center, 11/17-19 379 Wiederhold-AAAS Conf. & ASSA Conf., Chicago & Detroit, 12/26-28 382 Frey --SHARE Conf., L.A., 3/8-12 240 All Other Travel 1,547 3,600 4. , 000 (53) VI. BUDGET EXPENDITURE DETAILS Direct Costs Only August 1, 1970- August 1, 1971- July 31, 1971 July 31, 1972 Engineering Services 25,200 30, 000 Less portion of proceeds from sale 5 17,810 30,000 Publication Costs 4 000 4,000 Computer Services 360/ 67 8,000 5,000 IBM Education Courses 1,660 2,000 Total Computer Services 9,660 7,000 Other Expenditures Books and Periodicals Loo 500 Postage and Freight 600 600 Telephone 6,500 6,500 Physical Plant 200 718 Technical Services 200 300 Total Other Expenditures 7,900 8,618 GRAND TOTAL -- DIRECT COSTS 754,502 800, 900 ARRYTHEMIA DETECTIONS * Personnel Systems Programmer, one man-year 16,000 systems Programmer, one-half man-year 6,500 Research Associate, three man-months 5,000 Subtotal Salaries 27 300 Staff Benefits 4,562 Total Personnel 32,062 Technician Engineering Services LO, 0090 Supplies 1,000 Total estimated costs of core project 43,062 * Example of a medical computation application ACME would like to fund from revenue from fees for service. (54) VI. B. Summary of Resource Funding Source of Funds Computer Equipment - Service Biotech. Resources Branch Support Amount of Current Award: Tine (5) of Award Statement Adjustment from prior pericds: 1. Line (4) of current Award statement 2. ROE Adjustment Total BR Support TOTAL FUNDING BUDGET Actual Previous Budget Period $ 178,252 712,689 0 (76 ,459) $ 636,230 $ 814 ,48e BUDGET PERIODS Current Budget Period $ 160,000* 675,747 76,459 (17,883) $ 734,323 $ 894,323 Estimated Next Budget Period Approx. $ 250,000 17,883 $ 731,22 {Dependent on Tncome & Policy) * Extrapolation from funds from service charges August, 1970 through April, Lo71. W-E OY Postutelpo oq Oy 4 THle (56) 9€°S19 QT Ze Og “O9T Og 00° HOR (0S°00T ®) SNOT IBA Teutudey, uoTyeo tumuli, SsyTun 9 OTE? 00° elz 00° eT 00°09 Og 00°Oe (00°0¢g @) Q9-eT-t x (WIT) Wovd WSId sytun QT STeqyuey Jueudtnby Burqroddns 12°06L°92 = 1B OLEST ol TLe°er 00° T69 fO€ Teqo], uotyeanstsuop OS/o9E On’ TT6 On’ ey 00° LT? 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LOVANNVN NOILVOLALINGCI /NOT IAL YOSaa (°9U0D) LNENdINO dasvHound Modnd “TA (58) VI. BUDGET D. Budget Justification The budget does not reflect the shift in emphasis which is highlighted throughout this report, that ACME will give top priority in the coming year to designing and implementing a transitional system. After various preliminary studies have been completed, budget adjustments to accommo-~ date the needs as then forseen will be requested. Another significant point is the disposition of income earned through fee-for-service charges. ACME is proposing that the income revert to the Stanford medical communi- ty to support extensions of ACME's core research efforts. This item will be the topic of further discussion with NIH. Direct Costs An increase in direct cost of slightly less than $40,000 is requested for the next fiscal year, bringing the total direct cost base to $800,000. The increase over the current year will be used to create a small machine equipment pool, provide slightly more engineering services, and cover nermal cost escalation. No new positions are requested in the budget al- though a part of the numerical analyst position is shown in the NIH budget for the first time. ACME has used a faculty member on a half- time basis during the past year using University funds. The presence cf High level help in mathematics and numerical analysis has been helpful to both ACME staff and users. The expense associated with this 25% of full time salary commitment is less than the terminal leave funds ex- pended during the current year for David Cummins and Serge Girardi. The only other changes in the perscnnel budget are for merit increases. Equipment The equipment budget (lease and purchase) calls for a $135,000 net in- crease, The details supporting this estimate include two significant purchases. First, ACME intends to form a small machine equipment pool as described in Section III of this report. The $40,000 shown for this new activity will be supplemented in future years as the pool ex- pands. The second major equipment acquisition involves four alphanumeric displays with wpper and lower case. The cost estimate is based upon Beehive Model 4 units plus $800 per terminal for interface cards to the PDP-11, drivers, receivers, and cables. These units communicate with the PDP-11 at 4800 baud via an 8&bit serial interface. Two other equip- ment items are identified in the budget: engineering test equipment for the maintenance of existing equipment and two data sets which will permit data rates of 1200 baud between ACME and the 611 "add-on" dis- plays over normal telephone lines. Lease of the 360/50 system will cost less in the next fiscal year due to replacements ordered for disk drives and packs. An order has been placed to replace two 2314's with two 2319's at a monthly savings of roughly $100 each. During May, 1971. all TBM disk packs were replaced by 3M packs at a rental cost savings VI. BUDGET of roughly 50%. The complete savings is not apparent as nine of the packs which are actually part of the basic system have been charged in the past to a University account; next year's grant account will be paying for all packs. Finally, IBM rental costs will be decreased by five 2741 typewriter terminals four of which will be replaced by the alphanumeric displays. The fifth 2741 is being cancelled in order to keep the direct cost total within the $800,000 ceiling recommended by NIH Research Council. One change made this year in the equipment configuration will have neg- ligible effect on next year's budget, but it has materially affected service levels. The 270X and three 27OY's were purchased in conjunction with funds from the Genetics Department's Instrumentation Research Lab- oratory and the Chemistry Department in ACME's second year. This equip- ment was intended to serve as the medium rate interface between data gathering realtime users and the IBM 360/50 system but did not Live up to ACME's expectations. This year IBM bought the unit from Stanford. NIH grant's share of the proceeds from this resale was $27,802. These proceeds are being used this year to procure: RK-11, DEC Pack Disk Cartridge Drive Controller and DEC Pack Removable Disk Cartridge System $ 15,120 Interface to replace 270X/Y's 5,120 Engineering services for interface between PDP~1l and IBM 360/50 2,270 Total 22,510 Each of these items filled a need which the 270X7Y would have done if it operated satisfactorily. Since the sstimated cost of these items exceeds the sale proceeds, funds for part of the engineering services have been supplied from the general budget line item for engineering services. This leaves $5,292 in equipment sale proceeds which will be carried fer- ward to next fiscal year to fund replacements for other 270X/Y¥ functions. Supplies The supplies budget includes some inerveases. Comsumption of printer paper has risen sharply in recent months due to announcement cf new printing services for users. The budget for 360/67 services has been reduced from $8,000 to $5,000 in hopes that fewer core dumps and such servinces will be used. We have made no attempt to include /67 charges for mounting an interactive PL language. VI. BUDGET Arrhythmia Detection The last item in the detailed budget presentation is a cost estimate for the first year of the Arrhythmia Detection Development Program. Note that these costs are considered incremental over the $800,000 direct cost base budget. This extension to the ACME core research activity appears to present an improvement to medical care which can be justified by com- munity hospitals on a cost/performance basis. We hope that this work will be funded either through an increase in the base ACME budget cf di- rect cost orm through a new arrangement with respect to income from ACME users. Stanford has adopted a new basis for calculating indirect costs to be effective September 1, 1971. Modified direct costs will be used for ap- plying indirect costs. Since ACME charges a fee for services, there are questions of whether the full impact of the indirect costs should be levied on the RR-311 grant or be passed on to users. There will be no pyramiding of indirects. This budget assumes that users will be charged indirects on top of their ACME computer service charges. Therefore, the indirect rate of 46% of modified direct costs has been applied to ACME's estimated direct costs. This indirect figure of $171,085 will by reduced by 46% of the estimated income for FY1972. The conversion to this new method of applying indirect costs has raised numerous questions within the Stan- ford family. NIH will be notified prompthly of any changes tc the plan outlined here. E. Income Basis for Extension Request ACME requests an extension of 15 months in the three year grant expiring July 31, 19/2. The basis for this request is twofold. First, additional time is required to raise income; second, transition time is needed Income in the current year for ACME services will be approximately $1€0.000 to $170,000. The value of services provided by ACME to it's user community is far greater. For example, excluding utilization by ACME staff, income in the month of March would have been an excess of $60,000 if all users had been charged 2-1/2a¢ per pageminute. The 2-1/2¢ per pageminute rate in- cidentally is considered to be a full cost recovery rate and also a rate which would be competitive with other timesharing services. Thus, the prob- lem is to encourage current unfunded users to obtain University or outside funding for their research and teaching work. Furthermore, the subsidized users of ACME who now pay roughly 25% of the value of the services received will need to obtain enough incremental funding from their sponsoring agen- cles to continue these services. An estimate of income is attached which assumes that users will be successful in obtaining funds to support con- tinued use at higher rates (factor of 2 to 4 growth over present subsi- dized rates). These growth rates would still be less than estimated full cost recovery yet competitive rates. VI. BUDGET F. ACME Estimated Income Rate by End of FY1973 . Approximate Funded Projects Present Approximate Loss From Est. Rate(per April '71 Growth of Increased Net Category Description pemin. ) Act. Income Service Rate Rate Income 1 Real time, Medical 1/2¢ $4 55€ 3x 30% $ 3, 0OG school 2 Research, Medical 1g 8624 2X 25% 13, 000 school 3 Non Medical ef 498 5C0 8 Hospital Admini- 1 1/4 2769 2x 55% 2, 500 stration 9 Stanford Campus 21/2 2he1 2, 500 27, 500/mo. x12 Sub-total £330, OOO/yr. Core Research Projects (currently unfunded) 5 Real time, Core 1/26 320 3X 1, 000 Research 6 Medical Research, ig W531 2x 9, 000 Core Research 10, 000/mo. x12 Sub-total £120, O00/yr. Currently Unfunded Projects -student computing programs -Computing instruction for students See note 1 ~Unsponsored research for faculty «Pilot projects (old and new) and new users Sub-total $50, 000/yr. TOTAL $500, 000/yr. Note 1: We have not identified a future source of funding for these users. (62) VI. BUDGET Taking the availability of funds within the community into account, income from ACME users is more likely to be around $250,000 to $300,000 in FY1972 and less than $500,000 in FY1974. Although this level of income will not be adequate to support the present cost of offering ACME service, it is a Significant level of computing support to be provided from the Stanford community. If the income rate in the summer of 1974 were to exceed $650,000, the Stanford Medial School could likely affort to maintain a stand alone facility offering services exclusive of system development very similar to those now provided. If, on the otherhand, the total income from the medical community is less than 1/2 million dollars per year beyond July, 1973, mergers or joint ventures must be designed and implemented to be ready by that point in time. These will be explored over the next several months. (63) VII. UTILIZATION DATA A. Interpreting ACME Utilization The terms used to discuss ACME utilization involve charging units and categories of users. 1. Charging Units The computer service units for which ACME charges are: ® pageminutes ® terminal access hours ® blocks of disk storage ® terminal service charge 4k A pageminute is defined as occupancy of E5669 bytes of core for 1 minute. A user's program which occupies 10 pages of core would result in a charge of 10 pageminutes per minute of terminal access time. Terminal access time is the total number of minutes that a user's terminal is connected to the system in a logged-on condition. A block of disk storage is a fixed length block of 2,000 bytes of 2314 disk storage. The terminal service charge covers monthly terminal rent plus other services offered by the ACME staff to it's user community. This service charge is handled by the University independent from the ACME Grant. At the present time ACME does not charge for related services such as card reading, printing. and use of graphics terminals. 2. User Categories This table shows the Category identifier, rate, and definition of each user category at ACME. The rate charged per pageminute varies by user cate- gories and some categories are subsidized 100% by the ACME Grant. An asterisk next to the category identifier (x4) designates those so sub- sidized. All other categories are paying. There is a distinction be- tween realtime and non-realtime users. Realtime users use the 1800 pro- cessor or 2701 data adapter for data collection or process control func- tions in addition to the terminals. Category pairs 1 and 2, 5 and 6. 10 and 11, le and 13,and 14 and 15 differ from each other in only that cone respect. VIL. UTILIZATION DATA Category Rate/Pageminute Definition L 1/ea¢ Biomedical Research, Realtime. 2 1d¢ Biomedical Research. 3 e¢ Non- Stanford Medical Clinics and Research Foundations. xt 1¢ Medical Student education; includes graduate students and fellows. ¥D 1/2¢ Core Research, Realtime: Projects designated by the principal investigator. 6 1¢ Core Research. x7 1¢ ACME Staff. 8 1-1/4¢ Medical School and Hospital Administration. 9 2-1/2¢ Non Medical: Stanford University. *10 1/2¢ Pilot projects, Realtime. #11 1¢ Pilot Research. ¥1l2 and 13 Extended non funded: Extension of Categories LO and 11. 14 and 15 Suspended pending individual Institute approval (as of March 31, 1971, this category was merged with categories 1 and 2 respectively). VII. UTILIZATION DATA B. Utilization Trends The praph in Section VIIC. includes a six month moving average for page- minute utilization. This average has been hovering about 12 million page- minutes per month for the past year. In the month of April 1970, more than 2.5 million pageminutes were delivered. Taking into account the plans of various major users, we expect monthly utilization to average 2.5 to 2.8 million pageminutes per month for the next several months. This would represent approximately 20% growth over utilization figures for the past year. There is also additional utilization which this measure does not show: ACME has improved it's system efficiency and fewer pageminutes are required now to provide the same level of computing service as a year ago. The six month moving average for terminal hours has increased from 4100 hours in April 1970, to more than 3700 hours in April 1971. Despite wide monthly fluctuation, it appears that terminal usage is growing at the rate of approximately 20% per year. In February 1970, ACME announced a rate reduction to it's users but at the same time, started to charge for terminal assess time. Each terminal connected to the ACME system ties up a 2702 transmission control port. Since there are only 31 such ports in the ACME system, a pricing mechanism was needed to ration the resource. Terminal hours have increased despite this new accounting method. There is another change in utilization of ACME; one year ago one could commonly find 20 or more users logged-on during daytime hours with 30% to 40% of the users in execution. Today, when 20 or more users are logged-on, it is common to find 50% to 60% of them in execution. One might infer from this that users are doing less program development and more application work which is to be expected as the computing system matures. Use of the system during evening hours (8:00 ~ 10:00 p.m.) has increased by about 50% during this past year. As daytime utilization of the sys- tem increased, some users found computer service far better during the evening. Summer utilization generally exceeds winter utilization. June, July, and August are historically the periods of heavy use. Future computing requirements are not well defined. Last October and Nov- ember, a survey which indicated a broad spectrum of requirements was con- ducted in the Stanford Medical Center. The results of the survey are pre- sented in Part 4. Usage at ACME The system has had 365 pages (4, 000 bytes each) available for users since the last increment of core was added in January 1969. As of November 1970 the network included 53 2741 terminals. 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REPRESENTATIVE SAMPLE OF USER PROJECT DESCRIPTIONS Category 1 Name: Dong, E. Project: PATIENT Department: Cardiovascular Surgery Project Description: ACME has been used in collecting data from over 1400 patients. Data from cardiac surgery patients are entered and examined for survival, disease category electrocardiographic abnor- malities. Patients may be monitored on a FDP-12, with data then being transferred to ACME for storage. Name: Glick, >. Project: LASER Department: Pathology Project Description: The ACME Facility is needed to provide the computa- tional requirements of the laser microprobe analytical system which we have designed, and are continuing to develop, for elemental analysis of microscopic biological samples down to the single cell and very small volumes of fluids. The applications of the system to biological and medical research and clinical medicine obviously have impressive potential. ACME is involved in data calculation for definition of sample size as well as content and concentration of elements. Statis- tical evaluations include calculation of F-ratio, T-test, U-test, population means and also linear regressions, graphical interpolations and curve fitting. A second system has been built so that one can be devoted tc applications and the other to continued technological development. Eventually we expect to automate the system, which would further increase our dependence on ACME. Name: Harrison, D. Project: CATELAB Department: Cardiology Project Description: ACME is being used to analyze data for cardiac output using indicator dilution curve formularies, a variety of statistical analyses, text editing, and documented programs which are utilized on smaller computer systems. ACME is also being used to develop programs for the recognition of abnormal blood pressure and EKG complexes. Future use of ACME will involve the development of a software-hardware system for clinical monitoring of critically ill patients in a coronary care unit. ACME is intended to be employed as a source to document programs developed on a small medical system in a clinical environment. (71) VITI. REPRESENTATIVE SAMPLE OF USER PROJECT DESCRIPTIONS Name: Reynolds, W. (P.I.: Lederberg, J.) Project: S007 Department: Genetics Project Description: This project supports the basic development of automated mass spectrometer and other instrumentation systems. The mass spectrometer has become of interest in the biochemistry field. In the case of DNA and related structures, the basic principles involved are common to at least the Genetics Department and to the Organic Chemistry Department. Hence the efforts of this project span over five mass spectrometers in three diverse locations on the Stanford campus. The technical development consists in the origination of instrumenta- tion concepts and the realization, in both hardware and software, of complete operating systems. These systems are intended to automate the mass spectrometers and to provide the following benefits to the biological user-researcher: 1) Saving of the researcher's time in instrument operation and data reduction; 2) Improvement in the quality of the data; 3) Improvement in the presentation of the data; 4) Fostering of computer files of pertinent data. VIII. REPRESENTATIVE SAMPLE OF USER PROJECT DESCRIPTIONS Category 2 Name: Assaykeen, T. Project: RENIN Department: Urology Project Description: Previous research reported shows that in dogs insulin- induced hypoglycemia significantly increases plasma renin levels. These studies are being continued in order to attempt to determine what the stimulus to renin secretion is under these conditions and how this stimulus is transmitted to the juxtaglomerular cells. There is good evidence that the sympathetic nervous system can influence renin secretion but how this occurs is not known. This project is an attempt to establish whether catecholamines stimulate renin secretion through alpha or beta receptors, whether cyclic 3', 5' -AMP is involved and whether the effects of the catecholamines on renin secretion can be separated from the effects of these compounds on renal hemodynamics and function. The results of such studies may lend support to existing theories regard- ing the control of renin secretion or may give new insight concerning the physiologic control of this important endocrine system. Name: Bodmer, W. Project: POPGEN Department: Genetics Project Description: ACME is used for the analysis and interpretation of data on human white cell antigens. A secondary use is for the analysis and simulation of population genetic models. A series of programs nave been developed to facilitate the storage of data with appropriate edit- ing at the time of input and to facilitate a read interaction between the experimental worker and the computer. This allows one, at short notice, to do small scale 2 x 2 analyses for serum characterization, selection of appropriate individuals for absorbtion, and automatic typing according to complex patterns of serum reaction, These increased opportunities for interaction with the computer have been a great helr in day-to-day work and in establishing new relationships amongst sera. Future plans include the development of programs for the systematic analysis of family data. (73) VEITI. REPRESENTATIVE SAMPLE OF USER PROJECT DESCRIPTIONS Name: Forrest, W. (P.I.: Bellville, W.) Project: ANALGEST Department: Anesthesia Project Description: The 360/50 time-sharing real time system is used to research the management and statistical application of methods to the Cooperative Study. Problems of pilot studies, data validity, quality, cost of clinical trials and useful reduction of data for active sane management are constantly evaluated and updated. The plan is to develop an inexpensive system of quality and quantity control of large masses of clinical data from several sources so that diarrhea and "gigo" are diagnosed properly and treated prophylactically rather than symtomatically. Name: Friedland G. Project: SLING FT Department: Radiology Project Description: The purpose of this study was to determine the action of the gastric sling fibers. Radiopaque tantalum wire was inserted into the distal esophagus and gastric sling fibers in eleven cats. Subsequently, simultaneous biplane radiographs were obtained of the esophagus and stomach in the unanesthetized cats following installa- tion of barium into the upper esophagus. From these radiographs, the three dimensional movement of the markers was reconstructed using computer analysis. In two cats, two markers were placed on the anterior wall of the stomach close to the sling fibers in the direction of the long axis cf the stomach, determining the relationship between move- ment of the gastric wall and the sling fibers. All cats were autopsied immediately following the radiographic examination to determine the position of the markers. The sling fibers lengthened with distal esophageal opening in eight cats with correctly placed markers. In five of the eight cats, the distal esophagus closed within the time of the examination ana the sling fibers shortened simultaneously. There was no relationship between movement of the anterior wall of the stomach and the sling fibers. This study demonstrated for the first time that the gastric sling fibers act in concert with the distal esophagus. VIII. REPRESENTATIVE SAMPLE OF USER PROJECT DESCRIPTIONS Name: Herzenberg, hL. Project: LAB Department: Genetics Project Description: Studies in immunology, genetics, and maternal fetal immunologic relationships in the mouse require the collation of many experimental observations on a given serum sample or individual. Since such data is accumulated over long periods of time, frequent interim reviews must be made to determine new directions, ete. Currently, most data collation in the laboratory is done by hand incompletely, inadequate- ly and infrequently, thus hampering the process of the research. To overcome these difficulties, the process of changing data storage pro- cedures to utilize the ACME capabilities has begun. For example, all breeding records for the inbred nucleus of our mouse colony are stored in ACME. Approximately once a month ACME is called upon to draw updated pedigree charges, so that breeding decisions may be made. Programs have been written to collate multiple immunoglobulin level determinations done on individual serum samples, returning histories of immunoglobulin level changes with time in treated animals. ACME is being used to store data and direct antiserum production in tne labora- tory. In addition to the data storage aspects of ACME, the computer is used in this laboratory for a number of routine calculations on data sets, e.g., per cent antigen precipitated, geometric means of plaque events, etc. Name: Lamb, &. Froject: EMPIRE Department: Gynecology and Obstetrics Project Description: ACME is being used for the following studies: 1) Calculation of relative potency and confidence limits of total gonadotropin activity of human urine extracts. These calculations have been used in a research project correlating the results of the total gonadotropin bioassay and an immunologic assay for LH using hemagglutination inhibition. 2) Caleulation of results of chemical determinations of estriol in urine from women treated with gonadotropins for ovulation induction (research) and from pregnant women (service laboratory). 3) Calculation of conception rates using a modified life table method for estimating the prognosis for infertile couples. 4) Calculation of correlation between various parameters measured in the semen analysis with subsequent conception rates and with the result of a test for sperm agglutinins. 5} Tabulation of evaluations of student performance submitted by 2 large number of attending clinical faculty members. (75)