Grant No. RR 311-04
Section II-A

General Description of Resource Operation

Introduction: In its fourth year of existence, the ACME Project offered

the time-sharing and real-time data-acquisition services developed during the
first three years and sought to improve its level of service and reliability.
The most significant change during the past year has been the full implementa-
tion of “user fees." The fee for service concept was started in March, 1969,
but only recently have nearly all users become "eligible" for accepting charges
due to grant restrictions imposed by the National Institutes of Health.

A brief summary of the years events follows: July, 1969, was a record month
for terminal hours yielding 4,400 hours of terminal connect time. In August,
N.I.H. awarded a new grant covering ACME. During the fall of 1969, utilization
dropped markedly as the full impact of user charges became evident. Many new
contract and grant awards from Federal agencies provided fewer dollars than had
been hoped for and anticipated. January, 1970, marked the installation of an
additional 64,000 bytes of high-speed core on the 360/50. The effect of the
high-speed core addition was to cut compilation time in half. This also reduced
the effective page minute or core residency charges by providing users with more
efficient computing. In recent months the system appears to be achieving a new
equilibrium described in more detail below in the section on utilization. In
June, additional core for the 1800 will be ordered as will some additional CRI's.
Throughout the year, the staff emphasized tasks which would improve hardware and

software reliability.
Organizationally, two changes occurred in the past year. A new subcommittee
to the ACME Policy Committee was established to serve as a short and long-range

plan review group. This subcommittee consists of Dr. Elliot Levinthal, Dr. Edward
Grant No. RR 311-04
Section II-A

Feigenbaum, and Mr. Gio Wiederhold. In May, 1970, Mr. Ron Jamtgaard was appointed
Director of the ACME Facility.

In late May, the staff of ACME began an evaluation of various methods of
providing desired expansions to standard services. A key question involved
is the basic approach of adding one medium-sized satellite processor to handle
a variety of functions versus multiple mini-computing systems each handling one
or two functions. The study was extended into June, thereby missing the dead-
line for this report. Some of the incremental services being considered are:
multiple processor access to 2314 disk files; expansion of available 271 ports;
back-up or redundant capacity for recording data from real-time data-acquisi-
tion users; various fail-safe devices for terminal users; and allowance of
considerable expansion room in the field of graphics in terms of central hardware.

This Annual Report covers the period August 1, 1969 through May 31, 1970,
plus estimated operating results for the period through July 31, 1970. ACME
was created in July, 1966, under a three-year grant from National Institutes
of Health, Special Research Resources Branch. The initial goal was to provide
a time-shared computer facility and real-time, data-acquisition system for
research groups within the Stanford Medical Center. A second three year grant
was approved by NIH in August, 1969. The primary goal of the second three-
year grant has been improvement of reliability of both hardware and software.
The facility is administered by the Stanford Computation Center under the direc-
tion of Paul Armer.

The ACME System achieved the initial goal with considerable success. There
are over 200 projects presently on the system operating from some 50 terminals
in the Medical Center. In addition, there are twenty-one (21) laboratories

connected to ACME for real-time data-acquisition and process control.
Grant No. RR 311-04
Section [I-A

ACME's hardware consists of an IBM 360/50 with a 2-million byte extended
core storage, plus an IBM 1800 processing unit used for data-acquisition and
control of graphics devices. The language used is a subset of PL/1 which was
chosen for its power and ease of learning.

For more details on tasks accomplished during the past year and new "core
research" tasks started, refer to Description of Core Research Activities on
page 9.

SOME GOALS AND ACCOMPLISHMENTS OF PAST YEAR:

SOFTWARE RELIABILITY: In the grant proposal one year ago, it was noted that
software failures stem mainly from interface problems between IBM's Operating
System and the ACME system, error recovery procedures within OS, unanticipated
user demands, etc. Failure rates were shown to be dependent on the rate of
change of the software system. At that time, approximately one-third of the
total system failures were caused by software. One plan for the new grant
period was to reduce the number of modifications to the system by taking
advantage of the existing structure to meet new requirements. In practice,
this intent has been only partially satisfied. New software has been added to the
system using the basic structure (a command "Show Undefined", graphics control soft-
ware for "add on" graphics units to be used in conjunction with 2741 typewriter ter-
minals; ete....) However, some changes have called for modifications to the
basic structure: software for the link between Campus Facility 360/67 and the
ACME system, and a new communications software package for the 1800. The goal
was to improve the system to a point where software would be responsible for
system failure no more often than once every two to three weeks. Despite much
effort on this activity over the past nine months, software accounted for 10

failures between mid-April and mid-May. The effort will continue.
Grant No. RR 311-04
Section IT-A

HARDWARE RELIABILITY: The proposal cited three specific hardware boxes which
had caused an inordinate number of system failures -~ 2702 transmission control
unit, 7720 adapter for the 1800, and the 270X-Y high speed data transmission
units. The problems involving the 2702 device appear to have been solved.

This unit has failed only three times in the past year and has operated without
failure for the past nine months. The 7720 adapter for the 1800 continued to
provide some problems until a software solution was implemented. In addition,
a number of recent crashes of the 1800 system have been traced to the input/
output hardware. The cause of the problem remains unidentified. <A number of
IBM service personnel have been assigned to this task with no success to date.

The 270X high speed data transmission unit has proven totally unsatisfactory.
The unit was provided on an experimental basis by IBM, and was purchased jointly
by Dr. Djerassi's Chemistry Laboratory, Dr. Levinthal's Instrumentation Research
Laboratory, and ACME. In recent negotiations, IBM offered to buy back the 270X
and four 270Y's. In the near term ACME hopes to replace the 270X with a satellite
computer system. The exact configuration of the satellite system is dependent
upon. further study by ACME and the Chemistry Laboratory. The issue should be
resolved prior to the end of July, 1970.

During the past year ACME has monitored preventive maintenance work per-
formed by the manufacturer's Customer Engineer more closely. This step has
proven effective in isolating hardware from software problems and has helped
to keep hardware at a proper operational level.

A failure control program has been initiated. The system has been modified
so that many flaws which formerly caused the entire system to crash are now
trapped and allowed to impact only one user. ACME has taken over operation of

the machine hardware error interrupt operation.
Grant No. RR 311-04
Section III-A

REAL-TIME DATA ACQUISITION: The proposal called for two significant changes
on the 1800. First, more core storage was to be added in order to increase the
1800 capacity from 16 simultaneous lines to about 48 effective lines. Secondly,
software multiplexing was to provide an increase from 12 actual simultaneous
lines to approximately 24 effective lines. So far 12 actual lines have been
increased to 16 lines. However, the additional core is to be ordered in June,
1970 and this acquisition will permit the changes to be made. At the present
time, all core on the 1800 is full; a recent system change could not be implemen-
ted immediately due to a shortage of only 8 words of memory. It is packed tight.

SERVICE: ACME provides services for a wide variety of applications. The
system design is such that almost any user requirement can be met within the
existing framework. The uses of ACME fall into a number of discrete categories,
although a given user may have several projects which fall into different
categories.

Real-time data collection and analysis is a major category which may be sub-—
divided by data source and type of analysis. Sources which may be identified are:
direct input from instruments with a wide range of data acquisition rates - such
as mass spectrometers, blood analyzers gas chromatographs and related instruments;
direct input from subjects (human and animal) such as EEG, EKG, catheterization
pressures, respirator functions and other physiological parameters; and immediate
terminal input of experimental data. The types of analyses on these data are quite
varied. They include auto-correlations, cross-correlations, Fourier analysis, peak
location and classification programs, area determinations, and many others.

Mathematical modeling and computation is another category in which there is
considerable activity. Projects include neutron diffraction studies, molecular
modeling, respiratory function models, heart electrical activity models, and

other similar studies.
Grant No. RR 311-0)
Section II-A

In the category of data storage, retrieval and manipulation are projects in
human and animal genetics, psychological test data, a stroke registry, a drug
interaction study, and clinical laboratory data collection and dissemination.

It is expected that projects involving patient care will increase dramatically
in the near future.

DESCRIPTION OF CORE RESEARCH ACTIVITIES

The following paragraphs describe projects which are potentially useful to
several biomedical investigators. The identification of the need for research
in a particular computer application may originate with a single user; but the
ACME staff is aware of the possibilities of wider utilization. The staff is, of
course, at all times also concerned with improving the efficiency of the system
for the benefit of all users.

1. The STRUCTURE feature of the PL/1 language has been implemented on ACME
for data files. This feature allows the writing of mixed variable types into

a single file record such as a character string for a label and an array of
numeric data. Such record structures are frequently required for patient

record files and until now had to be simulated using characters only for

record fornats.

a. CSMP: The implementation of the Continuous Systems Modeling Program is
well underway. The ability to develop significant models of physiological process-
es is of major importance to predictive analysis of drug and other treatment
methods. We expect that a machine of the speed of ACME will not allow very
extensive simulation of physiological models, and that developed models will be
shipped over a link to the Campus Facility 360/67 for processing; but having
interactive capability during the model development process is essential for the
design and debugging of non-trivial processes without assistance of computer

specialists.
Grant No. RR 311-0h
Section II-A
3. Link: The hardware link between the ACME and Campus Facility systems is
complete and data has been transmitted experimentally over the link. At present,
user-oriented software is being written and a system to translate ACME to OS

files and the reverse is being coded.

h, Variable Length Files: A file system modification to allow records of any
size to be written is being developed. At present, individual records are
restricted to a maximum of 1984 characters per record. A by-product of this
modification will be the ability to handle a larger variety of storage devices
and as such a lessening of single vendor dependence

5. Small Machine Support: Improved support for small machine users is becoming
a major research effort. A small machine assembler has been written on ACME
which will generate codes for the PDP-8, PDP-12, LINK, LINK-8, or 1800. It

will be expanded to include other small machines as the need arises. The

assembler is conversational and offers powerful editing features. It is in

check-out phase at present and will soon provide software development for several

small machines currently in the laboratories of medical investigators.

6. 1800 Disk Spooling: The 1800 data collection system has been expanded to
include a facility for spooling data to the 1800 disk and retrieving it after
collection. This feature operates in a way which makes it independent of the
360/50 status and is therefore suitable for data collection on long experiments
(such as sleep experiments and long scintillation counter runs) when the main system
might be down or is being used for the nightly file maintenance procedures. This
continuous data collection task was identified in the proposal as a requirement.
T. 1800/360 Communications: The 1800/360 communication software has been
rewritten to provide greater speed and more sophisticated error recovery tech-
niques. As far as we know, we have been able to overcome (by programming ) IBM's
design deficiencies in its 1800/360 direct link and we are among the few, if

not the only installation, using this facility intensively. Double precision

LO
Grant No. RR 311-04
Section II-A

has been implemented for all arithmetic functions. These routines have been

thoroughly checked and rewritten where required for speed and accuracy.

8. Graphics: The proposal called for adding central hardware to accomodate up
to 16 CRT's. It was also assumed that a second interactive graphics unit would
be needed (see addendum to original proposal). In view of the high cost associ-
ated with the second interactive graphics unit, the limited budget, and the
general interest demonstrated in CRT's, the plan was changed. Instead of provid-
ing central hardware for 16 units, ACME has placed orders for "add on" type dis-
plays which will be available for users to mount in their laboratories and offices.
The units (including CRT and hardware interface) will cost slightly less than
$5,000 each. From three to six units should be available by late July or early
August, 1970.

9. Heuristic Problem Solving: In May, ACME started a new research effort by
adding one senior staff member with considerable experience in LISP. The LISP
language typically requires extensive amounts of core which ACME can provide.

By mid-summer, a batch version of LISP will be mounted during the overnight
service blocks on ACME. By late summer, an interpretive version of LISP will be
made available to ACME terminal users. The significance of this addition can
best be demonstrated in terms of a research project called DENDRAL involving

Drs. Joshua Lederberg and Edward Feigenbaum. The name "Dendral” was given an
algorithm developed by Lederberg which is capable of generating all of the
topologically possible isomers of a chemical formula. Heuristic DENDRAL will
perform the following two classes of tasks: (1) Given the mass spectrum of an
organic molecular sample and the chemical formula of the molecule, the program
will produce a short list of the molecular "graphs" as hypotheses to explain

the given data in the light of the program's models of mass spectrometric process-
es and stability of organic molecules. The list is rank-ordered from the most

satisfactory explanation to the least satisfactory; and (2) If no mass spectrum

il
Grant No. RR 311-04

Section II-A
is given, but only a formula, the program will produce a list of all the chen-
ically plausible isomers of the molecule in the light of its model of chemical
stability of organic molecules. According to Feigenbaum, "The flow diagram of
the system is a closed loop consisting of phases of data inspection, hypothesis
generation, prediction, and test, corresponding closely to a simple ‘scientific
method' loop." It is assumed that the results of DENDRAL operated on the ACME
system will lead others in the Medical School to investigate heuristic problem
solving techniques using computing.
10. File System Improvements: File system changes have been made to increase
ease of data manipulation. Increased utilization of the facility for data stor-
age and retrieval is anticipated, particularly by those involved in direct
patient care. The reliability record of the ACME file system gives cause for
considerable pride. Only two user data blocks have been lost in the entire
history of ACME,

TRAINING:

ACME continues to offer informal courses in the use of the system to both
beginning and advanced users. The beginning course is given an average of twice
monthly and the advanced class once a month. Class size is usually about ten
students. Each course consists of three one and one-half hour sessions. All
ACME programming personnel spend a portion of their time consulting with users.
In addition, three full-time and one part-time staff members are completely in-
volved with consulting for users.

A formal course in biomedical computing is now being offered to medical
students by the Genetics Department, using ACME as their primary computing system.

PLANS AND OBJECTIVES:

During FY 1971 and FY 1972 efforts will continue in the area of realiability. Soft-

12
Grant No. RR 311-04
Section II-A
ware reliability will improve as the basic system becomes increasingly stable.
Major work on hardware error recovery is indicated by the failure statistics.
As most hardware errors are transient in nature, and quite often only impact

a single user, it is obvious that considerable improvement can be made.

The 270X and four 270Y's will be replaced as soon as possible.

The 1800 core will be expanded by late summer. Increased usage is causing
some users to delay their experimental procedures while waiting for available
ports to the 1800. The storage scope displays are being supported on the 1800
in line with ACME policy to support all non-standard devices on the 1800 or
satellite system in order to insulate operation of the 360/50 from real time
users as much as possible. The 1800 is almost immune to external device failure
and therefore system reliability is enhanced. Small machine support will be a
major effort. In addition to the assembler, a method allowing the use of the
PL/ACME language and its compiler to compile code for small machines is being
investigated. New methods of allowing the small machines access to ACME are
under consideration. It is felt that the support of small machines is an area
that requires considerable research and cooperation to provide a true symbiotic
relationship.

The support of a version of the General Purpose Simulation System language
(GPSS) is under consideration. The language (GPSS) is designed for operations
research-type problems and would be very applicable to patient scheduling, clini-
cal laboratory systems, and similar activity modeling.

The plans for LISP have been described above. Hopefully, another team with-
in the Medical Center will be found with strong interest in problems which LISP
can readily support.

ACME will continue to expand its direct user support activities of teaching

13
Grant No. RR 311-04
Section II-A
and consulting. More sections of the Medical Center Will be introduced to ACME
and its capabilities. The direct patient care areas appear to be the most likely
candidates for near-term seminars and lectures on computing in general, and on
ACME. The data acquisition and control users of ACME are well established and
can be expected to grow, requiring from ACME a continued level of engineering
and consulting support.
UTILIZATION DATA:
On March 26, 1970 a rate change was announced to users. The change was
made retroactive to February 16. A summary of utilization data for the period
August, 1969 through May, 1970, is presented below.

Total Utilization from August 1969 - May 1970

Month Page Minutes Blocks
August 1969 2,605,374 135,632
September 2,633,017 124 443
October 1,773,297 116,272
November 1,576,599 114,130
December 2 002,03) 112,806
January 1970 1,637,933 112,122
February 1,875,170 107,812
March 2,604,178 115,308
April 2,356,168 108,059
May 2,546,881 106,660

Note that the above figures include utilization by ACME staff which normally
accounts for 10% to 14% of total usage of page minutes. A "page minute" is de-
fined as the holding of one page or 4,000 bytes in core for one minute. The

general downward trend in use of page minutes from August through January is

14
Grant No. RR 311-04
Section II-A
attributed to the inception of user charges, reduced availability of grant fund-
ing from Federal sources, and addition of high speed core on the Model 360/50.
Charging for ACME service was initiated in March, 1969; however, most users'
grants were not eligible to receive charges until later in the year. Various parts
of the ACME/PL system were moved from 8 microseconds bulk core to the incremental
high speed core added in January, 1970. The effect of this shift is to speed
up compiling, thereby resulting in fewer page minutes being charged to the user.

Note that the August, 1969 level of 2.6 million page minutes was nearly
attained in May, 1970 despite the effect of charging for services. Also
note that 2.54 million page minutes: in May reflects more computing than 2.6
pageminutes last August due to the addition of high speed core to the 360/50.

The number of terminal hours (2741 connected hours) dropped sharply from
a peak over 4400 hours in July, 1969, to about 2400 hours in December. The
effect was desired and predicted. By adding charges for system use, a system
of allocating scarce resources was implemented. Presumably, users make more
efficient use of terminal connect time. Since that time, about 50% of the drop
has been recouped. The past four months have been roughly equal in terms of
terminal hours.

ACME file utilization has remained essentially constant over the past six
months at about 70% of capacity. The present capacity is approximately 400
million bytes or two IBM 2314 Direct Access Storage Devices. In August, 1969,
disk usage hit a high of 86% of capacity. The reduction appears to be due to
the change to "fee for service" and to better knowledge on the part of users
about efficient file handling.

RATES FOR USER SERVICE CHARGES:

In addition to renting their terminals, ACME users are charged for two ele-

ments of service -- page minutes and disk storage. Page minutes are charged at

15
Grant No. RR 311-04
Section ITI-A

varying rates based upon a User's classification. For example, a lower rate is
charged to real-time data collection users involved in medical research than is
charged to non-medical or practicing clinical users. Some users are totally
supported by the Facility Grant; such users include medical students and research
users whose grants from NIH are ineligible to pay for computing.

After nearly one year of charging user fees, a rate reduction seemed to be
indicated. The revenue goals of the facility could be met despite a rate reduc-
tion. At the same time the funding of many medical research projects was reduc-
ed placing computing requirements in competition with other needs within limited
budgets. The rate change included the addition of a constant "add on" of two
and one-half pages to each program regardless of the program size. The intent
of this added charge was to increase the cost of tying up a terminal port for a
protracted time while using very few page minutes for computing. Limited port
capacity into the 360/50 (31 ports) coupled with certain user behavior led to
the adoption of this new rate.

In January, 1970 the 360/50 was upgraded by the addition of 64,000 bytes
(characters) of high-speed core memory. This resulted in an increase in system
speed of almost 50 percent. This was the only major modification during the
year to date. During the balance of the year, additional core for the 1800 will
be ordered as well as additional "add on" graphics CRT's.

The table on the next page compares the two rate schedules in effect during

the period covered by this report.

16
User Categories

Biomedical Research Service-
RealTime

Biomedical Research Service-
Routine Terminals

Biomedical Research Service-
Outside Stanford

Stanford Medical School and
Hospital Administration

Stanford, non-medical school

Pilot projects and projects
anticipating funding

Student education, Medical
School

ACME staff

All Chargeable users

Medical School students; pilot

3/21/69 - 4/15/70

Rate Per Page Minute

 

1¢
a¢
3¢

11/e ¢

3¢
x
No Charge

No Charge

No Charge

Storage Block per Month

project or funding antici-

pated; ACME staff

All Chargeable users

Medical School students, pilot

Connect Time charge

Grant No. RR 311-04
Section II-A

Approved RR 311-01
April 1, 1970

4/16/70

1/2¢

1¢

e¢

1 1/4¢

2 1/ea¢

No Charge

No Charge

No Charge

10¢

No Charge

21/2 page minutes X r(rate) X t(time)

project or funding antici-

pated; ACME staff

No Charge

* subject to approval of Subcommittee (of Policy Committee) on user charges.

17
 

 

 

 

 

 

 

 

 

 

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Peqaaog posed

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27